Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF627 ZNF20 ZNF845 DUXA ZNF559 ZNF184 BACH1 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	2.63e-08	1412	50	17	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF627 ZNF20 ZNF845 DUXA ZNF559 ZNF184 BACH1 ZNF813 ZNF611 ZNF534 ZNF578 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	2.76e-07	1459	50	16	GO:0000977
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1H CACNA1G	1.84e-05	3	50	2	GO:0008332
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1H CACNA1G RYR1	2.08e-04	46	50	3	GO:0005245
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1H CACNA1G	5.49e-04	14	50	2	GO:0008331
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF845 ZNF184 BACH1 ZNF813 ZNF611 ZNF534 ZNF578 ZNF281 ZNF513 ZNF304	8.85e-04	1244	50	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF845 ZNF184 BACH1 ZNF813 ZNF611 ZNF534 ZNF578 ZNF281 ZNF513 ZNF304	1.04e-03	1271	50	10	GO:0000987
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	CACNA1H CACNA1G	1.92e-03	26	50	2	GO:0005248
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1H CACNA1G RYR1	1.82e-04	46	50	3	GO:0005891
GeneOntologyCellularComponent	calcium channel complex	CACNA1H CACNA1G RYR1	7.12e-04	73	50	3	GO:0034704
GeneOntologyCellularComponent	voltage-gated sodium channel complex	CACNA1H CACNA1G	7.45e-04	17	50	2	GO:0001518
GeneOntologyCellularComponent	extrinsic component of presynaptic membrane	C1QC RIMS1	8.37e-04	18	50	2	GO:0098888
GeneOntologyCellularComponent	presynaptic active zone membrane	CACNA1H LPAR2 RIMS1	8.63e-04	78	50	3	GO:0048787
Domain	-	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	8.56e-12	679	49	16	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	1.19e-11	694	49	16	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	6.16e-11	775	49	16	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	6.40e-11	777	49	16	PS00028
Domain	Znf_C2H2-like	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	9.14e-11	796	49	16	IPR015880
Domain	Znf_C2H2	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	1.08e-10	805	49	16	IPR007087
Domain	ZnF_C2H2	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	1.14e-10	808	49	16	SM00355
Domain	zf-C2H2	ZNF627 ZNF20 ZNF845 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	1.46e-10	693	49	15	PF00096
Domain	KRAB	ZNF627 ZNF20 ZNF845 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZNF77 ZNF304	1.67e-09	358	49	11	PS50805
Domain	KRAB	ZNF627 ZNF20 ZNF845 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZNF77 ZNF304	1.67e-09	358	49	11	PF01352
Domain	KRAB	ZNF627 ZNF20 ZNF845 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZNF77 ZNF304	2.30e-09	369	49	11	SM00349
Domain	KRAB	ZNF627 ZNF20 ZNF845 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZNF77 ZNF304	2.36e-09	370	49	11	IPR001909
Domain	zf-C2H2_6	ZNF627 ZNF20 ZNF845 ZNF532 ZNF184 ZNF813 ZNF611 ZNF578 ZNF77	1.09e-07	314	49	9	PF13912
Domain	VDCC_T_a1	CACNA1H CACNA1G	2.02e-05	3	49	2	IPR005445
Domain	VDCCAlpha1	CACNA1H CACNA1G	2.99e-04	10	49	2	IPR002077
Domain	Ion_trans_dom	CACNA1H CACNA1G RYR1	3.33e-03	114	49	3	IPR005821
Domain	Ion_trans	CACNA1H CACNA1G RYR1	3.33e-03	114	49	3	PF00520
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF627 ZNF20 ZNF845 ZNF184 ZNF813 ZNF611 ZNF77	7.61e-09	181	50	7	37372979
Pubmed	Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.	CACNA1H CACNA1G	2.03e-06	2	50	2	23436820
Pubmed	Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.	CACNA1H CACNA1G	2.03e-06	2	50	2	14988077
Pubmed	Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.	CACNA1H CACNA1G	2.03e-06	2	50	2	21079360
Pubmed	Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.	CACNA1H CACNA1G	2.03e-06	2	50	2	21622683
Pubmed	Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.	CACNA1H CACNA1G	2.03e-06	2	50	2	31042060
Pubmed	The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	CACNA1H CACNA1G	2.03e-06	2	50	2	22886848
Pubmed	Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.	CACNA1H CACNA1G	2.03e-06	2	50	2	20685979
Pubmed	Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle.	CACNA1H RYR1	2.03e-06	2	50	2	37837625
Pubmed	Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.	CACNA1H CACNA1G	2.03e-06	2	50	2	29082441
Pubmed	[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].	CACNA1H CACNA1G	2.03e-06	2	50	2	22574369
Pubmed	Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.	CACNA1H CACNA1G	2.03e-06	2	50	2	21438841
Pubmed	T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.	CACNA1H CACNA1G	2.03e-06	2	50	2	22469755
Pubmed	β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.	CACNA1H CACNA1G	2.03e-06	2	50	2	22808078
Pubmed	5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone.	CACNA1H CACNA1G	6.07e-06	3	50	2	24327205
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1H CACNA1G	6.07e-06	3	50	2	23488970
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1H CACNA1G	6.07e-06	3	50	2	24966091
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1H CACNA1G	6.07e-06	3	50	2	26488564
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1H CACNA1G	6.07e-06	3	50	2	31919478
Pubmed	Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.	CACNA1H CACNA1G	6.07e-06	3	50	2	25825486
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1H CACNA1G	6.07e-06	3	50	2	18591418
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1H CACNA1G	6.07e-06	3	50	2	11230107
Pubmed	Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.	CACNA1H CACNA1G	6.07e-06	3	50	2	11897840
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1H CACNA1G	6.07e-06	3	50	2	28846697
Pubmed	Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.	CACNA1H CACNA1G	6.07e-06	3	50	2	21084288
Pubmed	Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.	CACNA1H CACNA1G	6.07e-06	3	50	2	33547341
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1H CACNA1G	6.07e-06	3	50	2	37739992
Pubmed	Calmodulin regulates Cav3 T-type channels at their gating brake.	CACNA1H CACNA1G	6.07e-06	3	50	2	28972185
Pubmed	Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.	CACNA1H CACNA1G	6.07e-06	3	50	2	11927664
Pubmed	ZnT-1 enhances the activity and surface expression of T-type calcium channels through activation of Ras-ERK signaling.	CACNA1H CACNA1G	6.07e-06	3	50	2	22572848
Pubmed	Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.	CACNA1H CACNA1G	1.21e-05	4	50	2	31800012
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1H CACNA1G	1.21e-05	4	50	2	21788606
Pubmed	Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.	CACNA1H CACNA1G	1.21e-05	4	50	2	28165634
Pubmed	T-type Ca2+ channels elicit pro-proliferative and anti-apoptotic responses through impaired PP2A/Akt1 signaling in PASMCs from patients with pulmonary arterial hypertension.	CACNA1H CACNA1G	1.21e-05	4	50	2	28655554
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1H CACNA1G	2.02e-05	5	50	2	12060068
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	CACNA1H CACNA1G	2.02e-05	5	50	2	29720258
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1H CACNA1G	4.23e-05	7	50	2	12900400
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1H CACNA1G	5.64e-05	8	50	2	28330839
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	CACNA1H CACNA1G	5.64e-05	8	50	2	34478646
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1H CACNA1G	5.64e-05	8	50	2	12761855
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1H CACNA1G	7.25e-05	9	50	2	16382099
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1H CACNA1G	9.05e-05	10	50	2	24778262
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1H CACNA1G	2.72e-04	17	50	2	27725084
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ZNF845 TRIM4 ZNF184 BACH1 MAML1 ZBTB3 ZNF281	9.62e-04	1103	50	7	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DUSP5 MAML1 CACNA1H SMG5 FBXO46 IFNLR1 RYR1	9.72e-04	1105	50	7	35748872
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	LNX2 RIMS1	1.17e-03	35	50	2	33864728
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1G RYR1	1.38e-03	38	50	2	30786075
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF845 DUXA ZNF813 ZNF611 ZNF534 MEIOSIN ZNF578 FBXO46 RYR1 ZNF304	5.36e-07	1192	50	10	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF627 ZNF20 NRTN ZNF559 LPAR2 ZNF491 ZNF77	2.42e-05	797	50	7	chr19p13
Cytoband	1p36.11	GPN2 C1QC IFNLR1	5.80e-05	68	50	3	1p36.11
Cytoband	19q13.41	ZNF611 ZNF534 ZNF578	8.73e-05	78	50	3	19q13.41
Cytoband	19p13.2	ZNF627 ZNF20 ZNF559 ZNF491	1.16e-04	229	50	4	19p13.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF627 ZNF20 ZNF845 ZNF532 ZNF559 ZNF184 ZNF813 ZNF611 ZNF534 ZNF578 ZBTB3 ZNF281 ZNF491 ZNF513 ZNF77 ZNF304	2.06e-12	718	42	16	28
GeneFamily	Calcium voltage-gated channel subunits	CACNA1H CACNA1G	1.65e-03	26	42	2	253
GeneFamily	Complement system\|Sushi domain containing	C1QC CFI	3.16e-03	36	42	2	492
Disease	response to mTOR inhibitor	BACH1 RIMS1	7.59e-04	25	48	2	EFO_0005417
Disease	Complement deficiency disease	C1QC CFI	1.32e-03	33	48	2	C0272242
Disease	Mitral valve prolapse	MEIOSIN FBXO46	1.58e-03	36	48	2	HP_0001634
Disease	factor VII activating protease measurement	ZNF20 SGSM1	3.64e-03	55	48	2	EFO_0009368

Protein segments in the cluster

Peptide	Gene	Start	Entry
RAHRSVLAACSSYFH	BACH1	46	O14867
LTAAHCLRASKTHRY	CFI	376	P05156
YIRDLSIHHTFSRCV	CEMIP	576	Q8WUJ3
SRYHTVHELSARECA	NRTN	181	Q99748
RRHHSTCEARYEAVS	MAML1	31	Q92585
LRLTAVHLVDSHYCT	GPN2	136	Q9H9Y4
EHVSCHPRYRETTLS	LPAR2	221	Q9HBW0
SEHHCLSARTIYTFS	IFNLR1	191	Q8IU57
RTTAYHHCTLLCSTD	LIPT1	171	Q9Y234
HSCHDIVLRRSYLGS	LNX2	596	Q8N448
ADTSLCRLYRHVSHD	FBXO46	441	Q6PJ61
SHCIFTIYLEAHSRT	KIF9	216	Q9HAQ2
AYALARCAVAHATHR	PSMB11	201	A5LHX3
LHRSSVSLDHCYLSL	MEIOSIN	431	C9JSJ3
HHALCLYESRLSAET	PTPRR	641	Q15256
SAECLHTTRHLVRHY	RIMS1	1031	Q86UR5
HASHTANLCVLLYRS	C1QC	171	P02747
HIIQRRSCSTSYSAR	CEP135	466	Q66GS9
EGLRRHLHCYRSSST	CD101	876	Q93033
DYSRFRLLVHHLCTS	CACNA1G	1596	O43497
HSAHCSFYRTRTLQA	DCX	31	O43602
SHRSYSCRVTHEGST	IGLC7	81	A0M8Q6
TRRSIHSLCTSHYLD	CACNA1H	1606	O95180
FHSHTLRLYRAVCAL	RYR1	1661	P21817
VSRRTSEACATHLHY	DUSP5	211	Q16690
ARRCRTTYSASQLHT	DUXA	101	A6NLW8
IHSRSTLECAYRTHL	SMG5	101	Q9UPR3
AYRRIHSLTHLDSVT	BRCC3	246	P46736
TFSRKSYLTCHRRLH	ZNF845	671	Q96IR2
SCRLCTFVSHYSSHL	ZNF513	151	Q8N8E2
CYTSHVSLSRHLFIV	ZNF532	1211	Q9HCE3
YSCSSSLRVHVRTHT	ZNF77	501	Q15935
TCSSSIRYHERTHTG	ZNF20	461	P17024
FSYKSSLTCHRRCHT	ZNF578	296	Q96N58
SFSYKSSLRCHRRLH	ZNF578	351	Q96N58
CRIHLSHFSLYTCVL	UNC5CL	221	Q8IV45
AFSCSSYIRIHERTH	ZNF627	231	Q7L945
SCSKYIRIHERTHTG	ZNF627	261	Q7L945
RHKSSLTYHCRIHTG	ZNF534	461	Q76KX8
CSAAFRSSYHLRRHV	ZNF281	266	Q9Y2X9
AYCRHLSTVRTHLSA	SGSM1	556	Q2NKQ1
SQTYSLTCHRRLHTG	ZNF813	281	Q6ZN06
DIFSTLRSSCLYRHH	YME1L1	171	Q96TA2
LYRHHSRALQSICSD	YME1L1	181	Q96TA2
ESTSSHCLLYRHALA	ZBED5	366	Q49AG3
DCLSLYLTHERTHTG	ZNF491	141	Q8N8L2
IRSSYCRKHERTHTI	ZNF491	421	Q8N8L2
SLTCHRRLHTGVKRY	ZNF611	301	Q8N823
FRHCSSLIYHRRLHT	ZNF611	631	Q8N823
KHRRVHTGARSYVCS	ZNF304	436	Q9HCX3
VHLHTFSCSSVSRLR	TRIM4	466	Q9C037
AFTRSTYLIRHLRSH	ZNF559	501	Q9BR84
FSYCSALIRHQRTHT	ZNF184	231	Q99676
RLALHGASCSTHSRA	USP54	831	Q70EL1
FSCSYTLRRHATVHT	ZBTB3	481	Q9H5J0