Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	complement component C3b binding	CFHR2 CFHR5 CR1 CR1L	1.15e-07	12	80	4	GO:0001851
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL3A1 COL5A2 VWF HMCN1 LTBP2 MUC2 SSPOP COL1A1	8.64e-07	188	80	8	GO:0005201
GeneOntologyMolecularFunction	opsonin binding	CFHR2 CFHR5 CR1 CR1L	2.83e-06	25	80	4	GO:0001846
GeneOntologyMolecularFunction	integrin binding	COL3A1 CCN4 VWF EGFR ICAM5 SRC ADAMTS13	6.53e-06	175	80	7	GO:0005178
GeneOntologyMolecularFunction	complement binding	CFHR2 CFHR5 CR1 CR1L	7.89e-06	32	80	4	GO:0001848
GeneOntologyMolecularFunction	complement component C3b receptor activity	CR1 CR1L	1.59e-05	2	80	2	GO:0004877
GeneOntologyMolecularFunction	complement component C4b receptor activity	CR1 CR1L	1.59e-05	2	80	2	GO:0001861
GeneOntologyMolecularFunction	complement component C4b binding	CR1 CR1L	4.74e-05	3	80	2	GO:0001855
GeneOntologyMolecularFunction	zinc ion binding	TRIM43B USP13 ADAMTS3 ADAMTS9 TRIM75 CIZ1 ANKIB1 NFXL1 BAZ1B TRIM43 ADAMTS13 ESCO1 MAP3K1	5.02e-05	891	80	13	GO:0008270
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL2	1.21e-04	120	80	5	GO:0004222
GeneOntologyMolecularFunction	microfibril binding	LTBP2 ADAMTSL2	2.35e-04	6	80	2	GO:0050436
GeneOntologyMolecularFunction	transition metal ion binding	TRIM43B USP13 ADAMTS3 ADAMTS9 TRIM75 CIZ1 ANKIB1 NFXL1 BAZ1B TRIM43 ADAMTS13 MUC2 ESCO1 MAP3K1	2.45e-04	1189	80	14	GO:0046914
GeneOntologyMolecularFunction	acyltransferase activity	TRIM43B ZDHHC21 TRIM75 RNF185 TRAIP BRPF1 ANKIB1 TRIM43 ESCO1 MAP3K1 HERC5	2.56e-04	775	80	11	GO:0016746
GeneOntologyMolecularFunction	protein tyrosine kinase activity	EPHB4 EGFR SRC BAZ1B PTK6	2.92e-04	145	80	5	GO:0004713
GeneOntologyMolecularFunction	opsonin receptor activity	CR1 CR1L	4.37e-04	8	80	2	GO:0001847
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM43B TRIM75 RNF185 TRAIP ANKIB1 TRIM43 MAP3K1 HERC5	6.09e-04	473	80	8	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM43B TRIM75 RNF185 TRAIP ANKIB1 TRIM43 HERC5	7.28e-04	372	80	7	GO:0061630
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring tensile strength	COL3A1 COL5A2 COL1A1	8.30e-04	46	80	3	GO:0030020
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine kinase activity	SRC BAZ1B PTK6	8.30e-04	46	80	3	GO:0004715
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRIM43B TRIM75 RNF185 TRAIP ANKIB1 TRIM43 MAP3K1 HERC5	1.02e-03	512	80	8	GO:0019787
GeneOntologyMolecularFunction	platelet-derived growth factor binding	COL3A1 COL1A1	1.02e-03	12	80	2	GO:0048407
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM43B TRIM75 RNF185 TRAIP ANKIB1 TRIM43 HERC5	1.08e-03	398	80	7	GO:0061659
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL2	1.25e-03	200	80	5	GO:0008237
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRIM43B TRIM75 RNF185 TRAIP ANKIB1 TRIM43 MAP3K1 HERC5	1.30e-03	532	80	8	GO:0016755
GeneOntologyMolecularFunction	complement receptor activity	CR1 CR1L	1.40e-03	14	80	2	GO:0004875
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	CYFIP1 CYFIP2	1.40e-03	14	80	2	GO:0000340
GeneOntologyMolecularFunction	endopeptidase activity	ADAMTS19 USP13 ADAMTS3 ADAMTS9 ADAMTS13 PLG ADAMTSL2	1.68e-03	430	80	7	GO:0004175
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	EPHB4 ANKK1 EGFR SRC SCYL3 BAZ1B DGKQ MAP3K1 PTK6	2.09e-03	709	80	9	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	EPHB4 ANKK1 EGFR SRC SCYL3 BAZ1B MAP3K1 PTK6	2.75e-03	600	80	8	GO:0004672
GeneOntologyMolecularFunction	RNA cap binding	CYFIP1 CYFIP2	3.17e-03	21	80	2	GO:0000339
GeneOntologyMolecularFunction	kinase activity	EPHB4 ANKK1 EGFR SRC SCYL3 BAZ1B DGKQ MAP3K1 PTK6	3.44e-03	764	80	9	GO:0016301
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activator activity	EGFR DGKQ	3.48e-03	22	80	2	GO:0030297
GeneOntologyMolecularFunction	growth factor binding	COL3A1 EGFR LTBP2 COL1A1	3.58e-03	156	80	4	GO:0019838
GeneOntologyMolecularFunction	virus receptor activity	EGFR CLEC4G CR1	4.83e-03	85	80	3	GO:0001618
GeneOntologyMolecularFunction	exogenous protein binding	EGFR CLEC4G CR1	4.99e-03	86	80	3	GO:0140272
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	EGFR MAP3K1	5.21e-03	27	80	2	GO:0004709
GeneOntologyMolecularFunction	protease binding	COL3A1 VWF PLG COL1A1	6.05e-03	181	80	4	GO:0002020
GeneOntologyMolecularFunction	ephrin receptor binding	SIPA1L1 SRC	7.27e-03	32	80	2	GO:0046875
GeneOntologyMolecularFunction	phospholipase binding	SRC DGKQ	7.27e-03	32	80	2	GO:0043274
GeneOntologyMolecularFunction	heparin binding	CCN4 ADAMTS3 RTN4R LTBP2	7.42e-03	192	80	4	GO:0008201
GeneOntologyBiologicalProcess	extracellular matrix organization	COL3A1 ADAMTS19 COL5A2 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 PLG ADAMTSL3 ADAMTSL2 COL1A1	3.06e-08	377	82	12	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	COL3A1 ADAMTS19 COL5A2 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 PLG ADAMTSL3 ADAMTSL2 COL1A1	3.15e-08	378	82	12	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	COL3A1 ADAMTS19 COL5A2 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 PLG ADAMTSL3 ADAMTSL2 COL1A1	3.25e-08	379	82	12	GO:0045229
GeneOntologyBiologicalProcess	complement activation	CFHR2 CFHR5 C6 CR1 CR1L	8.68e-06	70	82	5	GO:0006956
GeneOntologyBiologicalProcess	collagen fibril organization	COL3A1 ADAMTS19 COL5A2 ADAMTS3 COL1A1	1.30e-05	76	82	5	GO:0030199
GeneOntologyBiologicalProcess	platelet activation	COL3A1 VWF SRC DGKQ ADAMTS13 GNAS	3.98e-05	158	82	6	GO:0030168
GeneOntologyBiologicalProcess	positive regulation of activation of membrane attack complex	C6 CR1	4.67e-05	3	82	2	GO:0001970
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	COL3A1 EPHB4 CYFIP1 ADAMTS3 EGFR SIPA1L1 SPRY4 SRC FAM83G LTBP2 MAP3K1 CYFIP2 ADAMTSL2 PTK6 COL1A1	5.97e-05	1186	82	15	GO:0007167
GeneOntologyBiologicalProcess	regulation of body fluid levels	COL3A1 VWF EGFR SRC DGKQ ADAMTS13 GNAS PLG MUC2	6.45e-05	442	82	9	GO:0050878
GeneOntologyBiologicalProcess	biological process involved in symbiotic interaction	CFHR2 EGFR SRC CLEC4G CFHR5 PLG CR1 MUC2	7.74e-05	351	82	8	GO:0044403
GeneOntologyBiologicalProcess	blood coagulation	COL3A1 VWF SRC DGKQ ADAMTS13 GNAS PLG	7.93e-05	260	82	7	GO:0007596
GeneOntologyBiologicalProcess	coagulation	COL3A1 VWF SRC DGKQ ADAMTS13 GNAS PLG	9.14e-05	266	82	7	GO:0050817
GeneOntologyBiologicalProcess	regulation of activation of membrane attack complex	C6 CR1	9.32e-05	4	82	2	GO:0001969
GeneOntologyBiologicalProcess	hemostasis	COL3A1 VWF SRC DGKQ ADAMTS13 GNAS PLG	9.58e-05	268	82	7	GO:0007599
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	COL3A1 CYFIP1 ADAMTS3 EGFR SPRY4 SRC FAM83G LTBP2 MAP3K1 CYFIP2 ADAMTSL2 COL1A1	1.29e-04	850	82	12	GO:0071363
GeneOntologyBiologicalProcess	wound healing	COL3A1 CCN4 VWF SRC DGKQ ADAMTS13 GNAS PLG MAP3K1	1.48e-04	493	82	9	GO:0042060
GeneOntologyBiologicalProcess	regulation of complement activation	C6 CR1 CR1L	1.65e-04	27	82	3	GO:0030449
GeneOntologyBiologicalProcess	ERBB2 signaling pathway	EGFR SRC PTK6	1.65e-04	27	82	3	GO:0038128
GeneOntologyBiologicalProcess	response to growth factor	COL3A1 CYFIP1 ADAMTS3 EGFR SPRY4 SRC FAM83G LTBP2 MAP3K1 CYFIP2 ADAMTSL2 COL1A1	1.84e-04	883	82	12	GO:0070848
GeneOntologyBiologicalProcess	negative regulation of cell-substrate adhesion	SPRY4 SRC PLG COL1A1	2.16e-04	74	82	4	GO:0010812
GeneOntologyBiologicalProcess	cell-substrate adhesion	COL3A1 VWF ADAMTS9 SPRY4 SRC ADAMTS13 PLG COL1A1	2.25e-04	410	82	8	GO:0031589
GeneOntologyBiologicalProcess	activation of membrane attack complex	C6 CR1	2.32e-04	6	82	2	GO:0001905
GeneOntologyBiologicalProcess	response to wounding	COL3A1 CCN4 VWF RTN4R SRC DGKQ ADAMTS13 GNAS PLG MAP3K1	2.79e-04	659	82	10	GO:0009611
GeneOntologyBiologicalProcess	post-translational protein modification	TRIM43B USP13 TRIM75 RNF185 TRAIP ANKIB1 BAZ1B FBXL17 TRIM43 KLHL18 ESCO1 MAP3K1 HERC5	3.02e-04	1074	82	13	GO:0043687
GeneOntologyBiologicalProcess	neurotrophin TRK receptor signaling pathway	CYFIP1 SRC CYFIP2	3.32e-04	34	82	3	GO:0048011
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	COL3A1 SYDE2 SIPA1L1 RTN4R SPRY4 SRC MCF2L	3.62e-04	333	82	7	GO:0051056
GeneOntologyBiologicalProcess	anatomical structure homeostasis	COL3A1 EGFR CD38 SRC GNAS MUC2 CRB1	3.68e-04	334	82	7	GO:0060249
GeneOntologyBiologicalProcess	tissue homeostasis	COL3A1 EGFR CD38 SRC GNAS MUC2 CRB1	3.68e-04	334	82	7	GO:0001894
GeneOntologyBiologicalProcess	supramolecular fiber organization	COL3A1 ADAMTS19 COL5A2 CYFIP1 ADAMTS3 SRC FHOD3 LTBP2 DNAI3 MAP3K1 CYFIP2 COL1A1	3.85e-04	957	82	12	GO:0097435
GeneOntologyBiologicalProcess	positive regulation of Wnt signaling pathway	CCN4 EGFR SRC MAP3K1 COL1A1	4.20e-04	158	82	5	GO:0030177
GeneOntologyBiologicalProcess	negative regulation of complement activation, classical pathway	CR1 CR1L	4.30e-04	8	82	2	GO:0045959
GeneOntologyBiologicalProcess	positive regulation of neurotrophin TRK receptor signaling pathway	CYFIP1 CYFIP2	4.30e-04	8	82	2	GO:0051388
GeneOntologyBiologicalProcess	positive regulation of small GTPase mediated signal transduction	COL3A1 RTN4R SRC MCF2L	4.97e-04	92	82	4	GO:0051057
GeneOntologyBiologicalProcess	positive regulation of complement activation	C6 CR1	5.52e-04	9	82	2	GO:0045917
GeneOntologyBiologicalProcess	positive regulation of Rho protein signal transduction	COL3A1 RTN4R MCF2L	5.79e-04	41	82	3	GO:0035025
GeneOntologyBiologicalProcess	aorta morphogenesis	COL3A1 EPHB4 ADAMTS9	5.79e-04	41	82	3	GO:0035909
GeneOntologyBiologicalProcess	post-embryonic animal morphogenesis	GNAS CRB1	6.88e-04	10	82	2	GO:0009886
GeneOntologyBiologicalProcess	regulation of complement activation, classical pathway	CR1 CR1L	6.88e-04	10	82	2	GO:0030450
GeneOntologyBiologicalProcess	cytolysis by host of symbiont cells	CFHR2 CFHR5	6.88e-04	10	82	2	GO:0051838
GeneOntologyBiologicalProcess	complement activation, classical pathway	C6 CR1 CR1L	7.13e-04	44	82	3	GO:0006958
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine kinase signaling pathway	EPHB4 CYFIP1 ADAMTS3 EGFR SIPA1L1 SPRY4 SRC CYFIP2 PTK6 COL1A1	7.43e-04	747	82	10	GO:0007169
GeneOntologyBiologicalProcess	neurotrophin signaling pathway	CYFIP1 SRC CYFIP2	8.66e-04	47	82	3	GO:0038179
GeneOntologyBiologicalProcess	negative regulation of humoral immune response mediated by circulating immunoglobulin	CR1 CR1L	1.00e-03	12	82	2	GO:0002924
GeneOntologyCellularComponent	extracellular matrix	COL3A1 CCN4 ADAMTS19 COL5A2 LAMB4 ADAMTSL1 VWF HMCN1 ADAMTS3 ADAMTS9 WNT6 LTBP2 ADAMTS13 PLG ADAMTSL3 MUC2 SSPOP ADAMTSL2 COL1A1	5.19e-12	656	81	19	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL3A1 CCN4 ADAMTS19 COL5A2 LAMB4 ADAMTSL1 VWF HMCN1 ADAMTS3 ADAMTS9 WNT6 LTBP2 ADAMTS13 PLG ADAMTSL3 MUC2 SSPOP ADAMTSL2 COL1A1	5.47e-12	658	81	19	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	COL3A1 COL5A2 LAMB4 ADAMTSL1 VWF HMCN1 ADAMTS3 ADAMTS9 LTBP2 PLG MUC2 SSPOP COL1A1	1.20e-07	530	81	13	GO:0062023
GeneOntologyCellularComponent	fibrillar collagen trimer	COL3A1 COL5A2 COL1A1	1.20e-05	12	81	3	GO:0005583
GeneOntologyCellularComponent	banded collagen fibril	COL3A1 COL5A2 COL1A1	1.20e-05	12	81	3	GO:0098643
GeneOntologyCellularComponent	complex of collagen trimers	COL3A1 COL5A2 COL1A1	7.09e-05	21	81	3	GO:0098644
GeneOntologyCellularComponent	ruffle	CYFIP1 EGFR SPRY4 SRC GNAS PTK6	1.49e-04	206	81	6	GO:0001726
GeneOntologyCellularComponent	cell surface	TNFRSF9 VWF EGFR ADAMTS9 WNT6 RTN4R CD38 CLEC4G ADAMTS13 LY6K PLG CR1 CR1L	3.25e-04	1111	81	13	GO:0009986
GeneOntologyCellularComponent	cell leading edge	CYFIP1 EGFR SPRY4 SRC SCYL3 GNAS MCF2L PTK6	7.06e-04	500	81	8	GO:0031252
GeneOntologyCellularComponent	SCAR complex	CYFIP1 CYFIP2	9.54e-04	12	81	2	GO:0031209
GeneOntologyCellularComponent	dendritic growth cone	CYFIP1 SRC	9.54e-04	12	81	2	GO:0044294
GeneOntologyCellularComponent	endoplasmic reticulum lumen	COL3A1 COL5A2 ADAMTSL1 WNT6 ADAMTS13 COL1A1	1.83e-03	332	81	6	GO:0005788
GeneOntologyCellularComponent	side of membrane	TNFRSF9 VWF RTN4R CLEC4G LY6K GNAS PLG MCF2L CR1 CR1L	2.00e-03	875	81	10	GO:0098552
GeneOntologyCellularComponent	dendrite terminus	CYFIP1 SRC	2.69e-03	20	81	2	GO:0044292
GeneOntologyCellularComponent	membrane raft	EGFR RTN4R SRC LY6K CR1 CR1L	2.82e-03	362	81	6	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	EGFR RTN4R SRC LY6K CR1 CR1L	2.90e-03	364	81	6	GO:0098857
GeneOntologyCellularComponent	external side of plasma membrane	TNFRSF9 VWF RTN4R CLEC4G PLG CR1 CR1L	3.99e-03	519	81	7	GO:0009897
HumanPheno	Arteriovenous fistula	COL3A1 EPHB4 COL5A2 COL1A1	6.97e-07	12	33	4	HP:0004947
HumanPheno	Cervical insufficiency	COL3A1 COL5A2 COL1A1	9.87e-07	4	33	3	HP:0030009
HumanPheno	Abnormal uterine cervix morphology	COL3A1 COL5A2 PLG COL1A1	1.00e-06	13	33	4	HP:0012888
HumanPheno	Arteriovenous malformation	COL3A1 EPHB4 COL5A2 ADAMTS3 BAZ1B LTBP2 COL1A1	4.30e-06	108	33	7	HP:0100026
HumanPheno	Molluscoid pseudotumors	COL3A1 COL5A2 COL1A1	8.52e-06	7	33	3	HP:0000993
HumanPheno	Uterine prolapse	COL3A1 COL5A2 COL1A1	8.52e-06	7	33	3	HP:0000139
HumanPheno	Genital hernia	COL3A1 COL5A2 COL1A1	1.36e-05	8	33	3	HP:0100823
HumanPheno	Arterial rupture	COL3A1 COL5A2 COL1A1	1.36e-05	8	33	3	HP:0025019
HumanPheno	Cigarette-paper scars	COL3A1 COL5A2 COL1A1	2.88e-05	10	33	3	HP:0001073
HumanPheno	Arterial dissection	COL3A1 COL5A2 COL1A1	5.24e-05	12	33	3	HP:0005294
HumanPheno	Bladder diverticulum	COL3A1 COL5A2 BAZ1B COL1A1	7.43e-05	36	33	4	HP:0000015
HumanPheno	Subcutaneous spheroids	COL5A2 COL1A1	1.22e-04	3	33	2	HP:0025014
HumanPheno	Premature rupture of membranes	COL3A1 COL5A2 COL1A1	1.58e-04	17	33	3	HP:0001788
HumanPheno	Abnormal mitral valve morphology	COL3A1 COL5A2 VWF BAZ1B FHOD3 LTBP2 ADAMTSL2 COL1A1	1.74e-04	257	33	8	HP:0001633
HumanPheno	Piezogenic pedal papules	COL5A2 COL1A1	2.42e-04	4	33	2	HP:0025509
HumanPheno	Incisional hernia	COL5A2 COL1A1	2.42e-04	4	33	2	HP:0004872
HumanPheno	Abnormal atrioventricular valve morphology	COL3A1 ADAMTS19 COL5A2 VWF BAZ1B FHOD3 LTBP2 ADAMTSL2 COL1A1	2.71e-04	350	33	9	HP:0006705
HumanPheno	Prolonged bleeding time	COL5A2 VWF ADAMTSL2 COL1A1	2.73e-04	50	33	4	HP:0003010
HumanPheno	Subcutaneous nodule	COL3A1 COL5A2 KLLN GNAS COL1A1	3.19e-04	95	33	5	HP:0001482
HumanPheno	Abnormal atrioventricular valve physiology	ADAMTS19 COL5A2 BAZ1B FHOD3 LTBP2 ADAMTSL2 COL1A1	3.62e-04	215	33	7	HP:0031650
HumanPheno	Abnormality of the female genitalia	COL3A1 COL5A2 KLLN VWF TRAIP SPRY4 SRC BAZ1B EWSR1 GNAS PLG MAP3K1 COL1A1	4.01e-04	741	33	13	HP:0010460
HumanPheno	Laryngeal edema	EPHB4 PLG	4.02e-04	5	33	2	HP:0012027
HumanPheno	Scarring	COL3A1 EPHB4 COL5A2 ADAMTSL2 COL1A1	4.43e-04	102	33	5	HP:0100699
MousePheno	abnormal maternal decidual layer morphology	EGFR WNT6 CR1 CR1L	4.41e-06	25	63	4	MP:0004256
Domain	TSP_1	CCN4 ADAMTS19 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 C6 ADAMTSL3 SSPOP ADAMTSL2	1.94e-15	63	79	11	PF00090
Domain	TSP1	CCN4 ADAMTS19 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 C6 ADAMTSL3 SSPOP ADAMTSL2	2.80e-15	65	79	11	SM00209
Domain	TSP1_rpt	CCN4 ADAMTS19 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 C6 ADAMTSL3 SSPOP ADAMTSL2	2.80e-15	65	79	11	IPR000884
Domain	TSP1	CCN4 ADAMTS19 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 C6 ADAMTSL3 SSPOP ADAMTSL2	2.80e-15	65	79	11	PS50092
Domain	Peptidase_M12B_ADAM-TS	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 ADAMTSL2	6.03e-12	24	79	7	IPR013273
Domain	VWFC_1	COL3A1 CCN4 COL5A2 VWF MUC2 SSPOP COL1A1	1.40e-10	36	79	7	PS01208
Domain	VWC	COL3A1 CCN4 COL5A2 VWF MUC2 SSPOP COL1A1	2.10e-10	38	79	7	SM00214
Domain	VWFC_2	COL3A1 CCN4 COL5A2 VWF MUC2 SSPOP COL1A1	2.10e-10	38	79	7	PS50184
Domain	VWF_dom	COL3A1 CCN4 COL5A2 VWF MUC2 SSPOP COL1A1	4.42e-10	42	79	7	IPR001007
Domain	PLAC	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTSL3 ADAMTSL2	1.32e-08	19	79	5	PS50900
Domain	PLAC	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTSL3 ADAMTSL2	1.32e-08	19	79	5	IPR010909
Domain	VWC	COL3A1 CCN4 COL5A2 VWF COL1A1	1.08e-07	28	79	5	PF00093
Domain	PLAC	ADAMTS19 ADAMTSL1 ADAMTSL3 ADAMTSL2	2.87e-07	14	79	4	PF08686
Domain	CTCK_1	CCN4 VWF MUC2 SSPOP	8.67e-07	18	79	4	PS01185
Domain	ADAM_spacer1	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTSL2	2.47e-06	23	79	4	IPR010294
Domain	ADAM_spacer1	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTSL2	2.47e-06	23	79	4	PF05986
Domain	Sushi	CFHR2 CFHR5 C6 CR1 CR1L	2.65e-06	52	79	5	PF00084
Domain	CCP	CFHR2 CFHR5 C6 CR1 CR1L	3.20e-06	54	79	5	SM00032
Domain	Cys_knot_C	CCN4 VWF MUC2 SSPOP	3.51e-06	25	79	4	IPR006207
Domain	CTCK_2	CCN4 VWF MUC2 SSPOP	3.51e-06	25	79	4	PS01225
Domain	SUSHI	CFHR2 CFHR5 C6 CR1 CR1L	3.84e-06	56	79	5	PS50923
Domain	Sushi_SCR_CCP_dom	CFHR2 CFHR5 C6 CR1 CR1L	4.20e-06	57	79	5	IPR000436
Domain	Growth_fac_rcpt_	EPHB4 CCN4 TNFRSF9 HMCN1 EGFR LTBP2 CRB1	4.34e-06	156	79	7	IPR009030
Domain	Fib_collagen_C	COL3A1 COL5A2 COL1A1	1.17e-05	11	79	3	IPR000885
Domain	COLFI	COL3A1 COL5A2 COL1A1	1.17e-05	11	79	3	PF01410
Domain	NC1_FIB	COL3A1 COL5A2 COL1A1	1.17e-05	11	79	3	PS51461
Domain	Fib_collagen_C	COL3A1 COL5A2 COL1A1	1.17e-05	11	79	3	PD002078
Domain	COLFI	COL3A1 COL5A2 COL1A1	1.17e-05	11	79	3	SM00038
Domain	TIL	VWF MUC2 SSPOP	1.56e-05	12	79	3	PF01826
Domain	C8	VWF MUC2 SSPOP	1.56e-05	12	79	3	PF08742
Domain	Cytoplasmic_FMR1-int	CYFIP1 CYFIP2	1.77e-05	2	79	2	IPR008081
Domain	FragX_IP	CYFIP1 CYFIP2	1.77e-05	2	79	2	PF05994
Domain	Unchr_dom_Cys-rich	VWF MUC2 SSPOP	2.02e-05	13	79	3	IPR014853
Domain	C8	VWF MUC2 SSPOP	2.02e-05	13	79	3	SM00832
Domain	DISINTEGRIN_1	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	2.41e-05	40	79	4	PS00427
Domain	Reprolysin	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	2.41e-05	40	79	4	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	2.41e-05	40	79	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	2.41e-05	40	79	4	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	2.41e-05	40	79	4	IPR001590
Domain	TIL_dom	VWF MUC2 SSPOP	2.56e-05	14	79	3	IPR002919
Domain	Disintegrin_dom	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	2.67e-05	41	79	4	IPR001762
Domain	VWD	VWF MUC2 SSPOP	3.92e-05	16	79	3	SM00216
Domain	VWF_type-D	VWF MUC2 SSPOP	3.92e-05	16	79	3	IPR001846
Domain	VWFD	VWF MUC2 SSPOP	3.92e-05	16	79	3	PS51233
Domain	VWD	VWF MUC2 SSPOP	3.92e-05	16	79	3	PF00094
Domain	VWC_out	VWF MUC2 SSPOP	6.72e-05	19	79	3	SM00215
Domain	Znf_RING	TRIM43B RNF185 TRAIP ANKIB1 NFXL1 BAZ1B TRIM43 MAP3K1	7.03e-05	326	79	8	IPR001841
Domain	DUF1394	CYFIP1 CYFIP2	1.05e-04	4	79	2	PF07159
Domain	DUF1394	CYFIP1 CYFIP2	1.05e-04	4	79	2	IPR009828
Domain	CT	CCN4 VWF MUC2	1.06e-04	22	79	3	SM00041
Domain	-	TRIM43B USP13 RNF185 TRAIP BRPF1 ANKIB1 BAZ1B TRIM43 MAP3K1	1.15e-04	449	79	9	3.30.40.10
Domain	EGF_2	EPHB4 LAMB4 HMCN1 LTBP2 C6 SSPOP CRB1	1.30e-04	265	79	7	PS01186
Domain	Znf_RING/FYVE/PHD	TRIM43B USP13 RNF185 TRAIP BRPF1 ANKIB1 BAZ1B TRIM43 MAP3K1	1.36e-04	459	79	9	IPR013083
Domain	Pkinase_Tyr	EPHB4 ANKK1 EGFR SRC PTK6	2.18e-04	129	79	5	PF07714
Domain	ZF_RING_1	TRIM43B RNF185 TRAIP ANKIB1 NFXL1 TRIM43 MAP3K1	2.31e-04	291	79	7	PS00518
Domain	ZF_RING_2	TRIM43B RNF185 TRAIP ANKIB1 NFXL1 TRIM43 MAP3K1	2.67e-04	298	79	7	PS50089
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB4 ANKK1 EGFR SRC PTK6	2.98e-04	138	79	5	IPR001245
Domain	RING	TRIM43B RNF185 TRAIP ANKIB1 BAZ1B TRIM43 MAP3K1	3.07e-04	305	79	7	SM00184
Domain	MetalloPept_cat_dom	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	3.85e-04	81	79	4	IPR024079
Domain	-	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	3.85e-04	81	79	4	3.40.390.10
Domain	TyrKc	EPHB4 EGFR SRC PTK6	5.28e-04	88	79	4	SM00219
Domain	Tyr_kinase_cat_dom	EPHB4 EGFR SRC PTK6	5.28e-04	88	79	4	IPR020635
Domain	Peptidase_M12B_N	ADAMTS19 ADAMTS3 ADAMTS9	5.96e-04	39	79	3	IPR002870
Domain	Pep_M12B_propep	ADAMTS19 ADAMTS3 ADAMTS9	5.96e-04	39	79	3	PF01562
Domain	EGF_1	LAMB4 HMCN1 LTBP2 C6 SSPOP CRB1	7.38e-04	255	79	6	PS00022
Domain	PROTEIN_KINASE_TYR	EPHB4 EGFR SRC PTK6	7.62e-04	97	79	4	PS00109
Domain	Tyr_kinase_AS	EPHB4 EGFR SRC PTK6	7.62e-04	97	79	4	IPR008266
Domain	-	RBM5 EWSR1	7.78e-04	10	79	2	4.10.1060.10
Domain	ZINC_PROTEASE	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	7.92e-04	98	79	4	PS00142
Domain	Pept_M10_metallopeptidase	ADAMTS19 ADAMTS9 ADAMTS13	7.96e-04	43	79	3	IPR001818
Domain	EGF-like_CS	EPHB4 LAMB4 HMCN1 LTBP2 C6 CRB1	8.33e-04	261	79	6	IPR013032
Domain	Zinc_finger_PHD-type_CS	BRPF1 NFXL1 BAZ1B	2.63e-03	65	79	3	IPR019786
Domain	EGF_3	HMCN1 LTBP2 C6 SSPOP CRB1	3.20e-03	235	79	5	PS50026
Domain	zf-RanBP	RBM5 EWSR1	3.86e-03	22	79	2	PF00641
Domain	ZnF_RBZ	RBM5 EWSR1	4.22e-03	23	79	2	SM00547
Domain	ZF_RANBP2_2	RBM5 EWSR1	4.22e-03	23	79	2	PS50199
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 SSPOP ADAMTSL2	6.32e-12	39	64	8	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 SSPOP ADAMTSL2	6.32e-12	39	64	8	MM15165
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 SSPOP ADAMTSL2	6.85e-10	68	64	8	M27303
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 MUC2 SSPOP ADAMTSL2	1.37e-09	109	64	9	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 SSPOP ADAMTSL2	3.51e-08	111	64	8	M27416
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 SSPOP ADAMTSL2	2.52e-07	143	64	8	M27275
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	COL3A1 COL5A2 SRC COL1A1	1.42e-06	19	64	4	MM15512
Pathway	REACTOME_DEFECTS_OF_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF ADAMTS13 COL1A1	4.92e-06	8	64	3	M48236
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL3A1 COL5A2 VWF ADAMTS3 ADAMTS9 ICAM5 LTBP2 PLG COL1A1	7.83e-06	300	64	9	M610
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	COL3A1 COL5A2 SRC COL1A1	9.69e-06	30	64	4	M27772
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	COL3A1 COL5A2 SRC COL1A1	9.69e-06	30	64	4	MM15517
Pathway	REACTOME_DISEASES_OF_METABOLISM	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 ADAMTSL3 SSPOP ADAMTSL2	1.64e-05	250	64	8	M27554
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	VWF SRC COL1A1	1.91e-05	12	64	3	MM15093
Pathway	REACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING	VWF SRC COL1A1	1.91e-05	12	64	3	M27352
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF ADAMTS13 COL1A1	1.91e-05	12	64	3	MM15452
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	COL3A1 COL5A2 VWF ADAMTS3 ICAM5 LTBP2 PLG COL1A1	2.06e-05	258	64	8	MM14572
Pathway	WP_FOCAL_ADHESION	COL3A1 COL5A2 VWF EGFR SRC PTK6 COL1A1	2.12e-05	187	64	7	MM15913
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL3A1 COL5A2 VWF ICAM5 COL1A1	2.37e-05	76	64	5	MM14867
Pathway	KEGG_FOCAL_ADHESION	COL3A1 COL5A2 LAMB4 VWF EGFR SRC COL1A1	3.16e-05	199	64	7	M7253
Pathway	REACTOME_MET_PROMOTES_CELL_MOTILITY	COL3A1 COL5A2 SRC COL1A1	3.45e-05	41	64	4	M27778
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	COL3A1 COL5A2 LAMB4 VWF COL1A1	3.85e-05	84	64	5	M7098
Pathway	REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	COL3A1 COL5A2 VWF ICAM5 COL1A1	4.08e-05	85	64	5	M16441
Pathway	REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN	VWF ADAMTS13 COL1A1	4.79e-05	16	64	3	M9450
Pathway	REACTOME_DISEASES_OF_HEMOSTASIS	VWF ADAMTS13 COL1A1	8.21e-05	19	64	3	M48230
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	COL3A1 COL5A2 CYFIP1 EGFR SRC PLG CYFIP2 PTK6 COL1A1	1.06e-04	418	64	9	MM15587
Pathway	REACTOME_SIGNALING_BY_PDGF	COL3A1 COL5A2 SRC PLG	1.27e-04	57	64	4	MM14713
Pathway	REACTOME_SIGNALING_BY_PDGF	COL3A1 COL5A2 SRC PLG	1.36e-04	58	64	4	M2049
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	VWF C6 PLG CR1	1.36e-04	58	64	4	M39649
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	VWF C6 PLG CR1	1.46e-04	59	64	4	M48343
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL3A1 COL5A2 ADAMTS3 COL1A1	1.66e-04	61	64	4	MM14637
Pathway	REACTOME_SIGNALING_BY_MET	COL3A1 COL5A2 SRC COL1A1	2.39e-04	67	64	4	MM15345
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL3A1 COL5A2 ADAMTS3 COL1A1	2.39e-04	67	64	4	M26999
Pathway	REACTOME_SYNDECAN_INTERACTIONS	COL3A1 COL5A2 COL1A1	2.42e-04	27	64	3	M27217
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	VWF C6 PLG CR1	2.68e-04	69	64	4	M16894
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	EGFR SRC COL1A1	2.70e-04	28	64	3	M39572
Pathway	WP_FOCAL_ADHESION	COL5A2 VWF EGFR SRC PTK6 COL1A1	2.79e-04	199	64	6	M39402
Pathway	REACTOME_PTK6_PROMOTES_HIF1A_STABILIZATION	EGFR PTK6	3.01e-04	6	64	2	M27754
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFHR2 CFHR5	3.01e-04	6	64	2	M47880
Pathway	REACTOME_PTK6_PROMOTES_HIF1A_STABILIZATION	EGFR PTK6	3.01e-04	6	64	2	MM15500
Pathway	PID_AVB3_INTEGRIN_PATHWAY	COL3A1 COL5A2 SRC COL1A1	3.50e-04	74	64	4	M160
Pathway	REACTOME_COLLAGEN_FORMATION	COL3A1 COL5A2 ADAMTS3 COL1A1	3.88e-04	76	64	4	MM14573
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL3A1 COL5A2 COL1A1	4.03e-04	32	64	3	MM14924
Pathway	REACTOME_ENHANCED_BINDING_OF_GP1BA_VARIANT_TO_VWF_MULTIMER_COLLAGEN	VWF COL1A1	4.20e-04	7	64	2	M48265
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL3A1 COL5A2 ADAMTS9 PLG COL1A1	4.28e-04	140	64	5	M587
Pathway	REACTOME_SIGNALING_BY_MET	COL3A1 COL5A2 SRC COL1A1	4.50e-04	79	64	4	M27643
Pathway	REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES	COL3A1 COL5A2 CYFIP1 EGFR SRC PLG CYFIP2 PTK6 COL1A1	6.28e-04	532	64	9	M27870
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	VWF SRC COL1A1	6.72e-04	38	64	3	MM15456
Pathway	REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	VWF SRC COL1A1	7.26e-04	39	64	3	M10735
Pathway	REACTOME_COLLAGEN_FORMATION	COL3A1 COL5A2 ADAMTS3 COL1A1	7.37e-04	90	64	4	M631
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL3A1 COL5A2 COL1A1	8.41e-04	41	64	3	MM15538
Pathway	PID_UPA_UPAR_PATHWAY	EGFR SRC PLG	9.03e-04	42	64	3	M174
Pathway	WP_COMPLEMENT_SYSTEM	CFHR2 C6 PLG CR1	9.39e-04	96	64	4	M39581
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL3A1 COL5A2 COL1A1	1.03e-03	44	64	3	M27812
Pathway	REACTOME_SIGNALING_BY_ERBB2	EGFR SRC PTK6	1.03e-03	44	64	3	MM14520
Pathway	BIOCARTA_EGFR_SMRTE_PATHWAY	EGFR MAP3K1	1.09e-03	11	64	2	M18837
Pathway	BIOCARTA_EGFR_SMRTE_PATHWAY	EGFR MAP3K1	1.09e-03	11	64	2	MM1432
Pathway	REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING	EGFR PTK6	1.09e-03	11	64	2	MM15478
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	EGFR SRC GNAS MAP3K1	1.13e-03	101	64	4	M1979
Pathway	PID_SYNDECAN_1_PATHWAY	COL3A1 COL5A2 COL1A1	1.18e-03	46	64	3	M198
Pathway	REACTOME_ECM_PROTEOGLYCANS	COL3A1 COL5A2 COL1A1	1.25e-03	47	64	3	MM14925
Pathway	PID_ERBB1_DOWNSTREAM_PATHWAY	EGFR SRC MAP3K1 CYFIP2	1.31e-03	105	64	4	M164
Pathway	REACTOME_SIGNALING_BY_ERBB2	EGFR SRC PTK6	1.50e-03	50	64	3	M553
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	COL3A1 COL5A2 COL1A1	1.50e-03	50	64	3	MM14796
Pathway	REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING	EGFR PTK6	1.53e-03	13	64	2	M27729
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	EGFR MAP3K1	1.53e-03	13	64	2	M47594
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL3A1 COL5A2 PLG COL1A1	1.77e-03	114	64	4	MM14571
Pathway	REACTOME_COLLAGEN_DEGRADATION	COL3A1 COL5A2 COL1A1	1.78e-03	53	64	3	MM14566
Pathway	REACTOME_COMPLEMENT_CASCADE	CFHR2 CFHR5 C6 CR1	1.83e-03	115	64	4	M19752
Pathway	WP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER	EGFR SRC COL1A1	1.88e-03	54	64	3	M42568
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC	2.05e-03	15	64	2	M12101
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC	2.05e-03	15	64	2	M1262
Pathway	REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC	2.05e-03	15	64	2	MM14959
Pathway	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	VWF SRC	2.05e-03	15	64	2	MM14961
Pathway	BIOCARTA_SPRY_PATHWAY	EGFR SPRY4	2.34e-03	16	64	2	MM1500
Pathway	REACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS	COL3A1 COL5A2 COL1A1	2.42e-03	59	64	3	M27218
Pathway	BIOCARTA_SPRY_PATHWAY	EGFR SPRY4	2.64e-03	17	64	2	M1389
Pathway	PID_SYNDECAN_3_PATHWAY	EGFR SRC	2.64e-03	17	64	2	M251
Pathway	REACTOME_GAB1_SIGNALOSOME	EGFR SRC	2.64e-03	17	64	2	MM14700
Pathway	PID_NFKAPPAB_ATYPICAL_PATHWAY	SRC SSPOP	2.64e-03	17	64	2	M26
Pathway	REACTOME_GAB1_SIGNALOSOME	EGFR SRC	2.64e-03	17	64	2	M10450
Pathway	REACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES	COL3A1 COL5A2 COL1A1	2.66e-03	61	64	3	M27103
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	COL3A1 COL5A2 SRC	2.92e-03	63	64	3	M11187
Pathway	BIOCARTA_41BB_PATHWAY	TNFRSF9 MAP3K1	2.96e-03	18	64	2	M2064
Pathway	REACTOME_EPHRIN_SIGNALING	EPHB4 SRC	2.96e-03	18	64	2	MM15024
Pathway	BIOCARTA_41BB_PATHWAY	TNFRSF9 MAP3K1	2.96e-03	18	64	2	MM1511
Pathway	WP_MIR5093P_ALTERATION_OF_YAP1ECM_AXIS	COL3A1 COL1A1	2.96e-03	18	64	2	M39421
Pathway	REACTOME_COLLAGEN_DEGRADATION	COL3A1 COL5A2 COL1A1	3.05e-03	64	64	3	M26953
Pathway	REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL	COL3A1 ICAM5 CLEC4G COL1A1	3.28e-03	135	64	4	MM14781
Pathway	REACTOME_EPHRIN_SIGNALING	EPHB4 SRC	3.30e-03	19	64	2	M27310
Pathway	REACTOME_SCAVENGING_BY_CLASS_A_RECEPTORS	COL3A1 COL1A1	3.30e-03	19	64	2	M27221
Pathway	PID_INTEGRIN1_PATHWAY	COL3A1 COL5A2 COL1A1	3.33e-03	66	64	3	M18
Pathway	WP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT	EGFR MAP3K1	3.66e-03	20	64	2	MM15907
Pathway	REACTOME_NCAM1_INTERACTIONS	COL3A1 COL5A2	3.66e-03	20	64	2	MM15061
Pathway	WP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT	EGFR MAP3K1	3.66e-03	20	64	2	M39624
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_TO_RAC_SIGNALING_PATHWAY	CYFIP1 CYFIP2	3.66e-03	20	64	2	M47737
Pathway	WP_UROTENSINIIMEDIATED_SIGNALING	COL3A1 EGFR COL1A1	3.78e-03	69	64	3	M48052
Pathway	PID_ECADHERIN_KERATINOCYTE_PATHWAY	EGFR SRC	4.03e-03	21	64	2	M184
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_ACTIN_SIGNALING_PATHWAY	EGFR SRC	4.03e-03	21	64	2	M47722
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	ZDHHC21 EGFR SRC	4.09e-03	71	64	3	MM15590
Pathway	WP_BLOOD_CLOTTING_CASCADE	VWF PLG	4.42e-03	22	64	2	M39480
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	CCN4 ADAMTS19 ADAMTSL1 HMCN1 ADAMTS3 ADAMTS9 ADAMTS13 C6 ADAMTSL3 SSPOP ADAMTSL2	3.11e-17	75	83	11	20637190
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	COL3A1 COL5A2 ADAMTSL1 VWF HMCN1 LTBP2 PLG MUC2 COL1A1	2.65e-10	167	83	9	22159717
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL3A1 COL5A2 ADAMTSL1 VWF HMCN1 LTBP2 PLG SSPOP COL1A1	4.01e-10	175	83	9	28071719
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	COL3A1 HMCN1 ADAMTS3 ADAMTS9 SSPOP COL1A1	1.03e-08	64	83	6	22261194
Pubmed	Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy.	VWF ADAMTS13 PLG	1.31e-08	3	83	3	24449821
Pubmed	ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.	ADAMTSL1 ADAMTSL3 ADAMTSL2	1.31e-08	3	83	3	14667842
Pubmed	Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.	COL3A1 COL5A2 VWF SPRY4 COL1A1	3.70e-08	39	83	5	30566624
Pubmed	ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.	ADAMTS19 ADAMTS3 ADAMTS13	5.23e-08	4	83	3	28088271
Pubmed	Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow?	COL3A1 VWF COL1A1	2.61e-07	6	83	3	20063990
Pubmed	Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.	COL3A1 ADAMTS3 COL1A1	2.61e-07	6	83	3	16556917
Pubmed	Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance.	COL3A1 COL5A2 COL1A1	7.28e-07	8	83	3	18816857
Pubmed	Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.	COL3A1 COL5A2 SPRY4 COL1A1	1.03e-06	32	83	4	27770432
Pubmed	Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.	C6 CR1 CR1L	1.09e-06	9	83	3	18947875
Pubmed	Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.	COL3A1 ADAMTS19 COL1A1	1.09e-06	9	83	3	31844321
Pubmed	Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.	EGFR SPRY4 SRC	1.55e-06	10	83	3	18273061
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	COL3A1 ADAMTSL2 COL1A1	1.55e-06	10	83	3	30738849
Pubmed	Interaction of Smads with collagen types I, III, and V.	COL3A1 COL5A2 COL1A1	1.55e-06	10	83	3	14559231
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS3 ADAMTS9 ADAMTS13	1.55e-06	10	83	3	11167130
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	COL3A1 COL5A2 VWF PLG MUC2 COL1A1	1.88e-06	153	83	6	25037231
Pubmed	SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.	COL3A1 PLG COL1A1	2.13e-06	11	83	3	2745554
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ADAMTSL1 MAPKBP1 ADAMTSL3 SSPOP ADAMTSL2	5.49e-06	105	83	5	9628581
Pubmed	Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid haemorrhage.	VWF ADAMTS13	5.63e-06	2	83	2	28102428
Pubmed	The association between the L1565 variant of von Willebrand factor and susceptibility to proteolysis by ADAMTS13.	VWF ADAMTS13	5.63e-06	2	83	2	17296575
Pubmed	Interrelationship between ADAMTS13 activity, von Willebrand factor, and complement activation in remission from immune-mediated trhrombotic thrombocytopenic purpura.	VWF ADAMTS13	5.63e-06	2	83	2	32065383
Pubmed	Functional identification of transcription control sequences of the mouse Crry gene.	CR1 CR1L	5.63e-06	2	83	2	8335915
Pubmed	ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.	VWF ADAMTS13	5.63e-06	2	83	2	22983446
Pubmed	N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity.	VWF ADAMTS13	5.63e-06	2	83	2	18981290
Pubmed	The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.	VWF ADAMTS13	5.63e-06	2	83	2	15975930
Pubmed	Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma.	EGFR SRC	5.63e-06	2	83	2	18594011
Pubmed	Transcriptional Regulation of Connective Tissue Metabolism Genes in Women With Pelvic Organ Prolapse.	COL3A1 COL1A1	5.63e-06	2	83	2	27636223
Pubmed	A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13.	VWF ADAMTS13	5.63e-06	2	83	2	21779388
Pubmed	Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13.	VWF ADAMTS13	5.63e-06	2	83	2	25201004
Pubmed	Interactions of von Willebrand factor and ADAMTS13 in von Willebrand disease and thrombotic thrombocytopenic purpura.	VWF ADAMTS13	5.63e-06	2	83	2	25010251
Pubmed	The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen.	COL3A1 VWF	5.63e-06	2	83	2	16420575
Pubmed	Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology.	VWF ADAMTS13	5.63e-06	2	83	2	21512165
Pubmed	Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.	VWF ADAMTS13	5.63e-06	2	83	2	26168189
Pubmed	Multi-step binding of ADAMTS-13 to von Willebrand factor.	VWF ADAMTS13	5.63e-06	2	83	2	19765212
Pubmed	Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.	EGFR SRC	5.63e-06	2	83	2	11983694
Pubmed	FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients.	VWF ADAMTS13	5.63e-06	2	83	2	24740645
Pubmed	Crry/p65, a membrane complement regulatory protein, has costimulatory properties on mouse T cells.	CR1 CR1L	5.63e-06	2	83	2	10779754
Pubmed	Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation.	VWF ADAMTS13	5.63e-06	2	83	2	27444201
Pubmed	Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis.	VWF ADAMTS13	5.63e-06	2	83	2	24106205
Pubmed	Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.	CR1 CR1L	5.63e-06	2	83	2	16444293
Pubmed	Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure.	VWF ADAMTS13	5.63e-06	2	83	2	19190805
Pubmed	Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia.	VWF ADAMTS13	5.63e-06	2	83	2	19190814
Pubmed	Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia.	CYFIP1 CYFIP2	5.63e-06	2	83	2	38128786
Pubmed	Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration.	CFHR2 CFHR5	5.63e-06	2	83	2	34260947
Pubmed	ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men.	VWF ADAMTS13	5.63e-06	2	83	2	17053057
Pubmed	Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients.	VWF ADAMTS13	5.63e-06	2	83	2	33606732
Pubmed	Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B.	VWF ADAMTS13	5.63e-06	2	83	2	20200350
Pubmed	A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides.	COL3A1 VWF	5.63e-06	2	83	2	16912226
Pubmed	Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13.	VWF ADAMTS13	5.63e-06	2	83	2	19812385
Pubmed	Differential expression of procollagen genes between mid- and late-gestational fetal fibroblasts.	COL3A1 COL1A1	5.63e-06	2	83	2	19560165
Pubmed	Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.	VWF ADAMTS13	5.63e-06	2	83	2	29729651
Pubmed	Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1.	CR1 CR1L	5.63e-06	2	83	2	1730912
Pubmed	Collagen synthesis is not altered in women with stress urinary incontinence.	COL3A1 COL1A1	5.63e-06	2	83	2	15227656
Pubmed	Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.	VWF ADAMTS13	5.63e-06	2	83	2	16141351
Pubmed	Domain-specific mechanical modulation of VWF-ADAMTS13 interaction.	VWF ADAMTS13	5.63e-06	2	83	2	31067148
Pubmed	Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).	VWF ADAMTS13	5.63e-06	2	83	2	21705658
Pubmed	Insights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13.	VWF ADAMTS13	5.63e-06	2	83	2	33343584
Pubmed	Zinc and calcium ions cooperatively modulate ADAMTS13 activity.	VWF ADAMTS13	5.63e-06	2	83	2	16286459
Pubmed	von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain.	VWF ADAMTS13	5.63e-06	2	83	2	30936056
Pubmed	von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans.	VWF ADAMTS13	5.63e-06	2	83	2	25977583
Pubmed	Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation.	COL3A1 COL1A1	5.63e-06	2	83	2	23040566
Pubmed	Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.	VWF ADAMTS13	5.63e-06	2	83	2	16322474
Pubmed	Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis.	CR1 CR1L	5.63e-06	2	83	2	19740350
Pubmed	An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF.	VWF ADAMTS13	5.63e-06	2	83	2	20032502
Pubmed	The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants.	EGFR SRC	5.63e-06	2	83	2	19305428
Pubmed	Development of a Hyperactive Primary Hemostatic System During Off-Pump Lung Transplantation Resulting From an Unbalance Between von Willebrand Factor and Its Cleaving Protease ADAMTS13.	VWF ADAMTS13	5.63e-06	2	83	2	25846964
Pubmed	The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke.	VWF ADAMTS13	5.63e-06	2	83	2	29887594
Pubmed	Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13.	VWF ADAMTS13	5.63e-06	2	83	2	19897584
Pubmed	The juxtamembrane region of the epidermal growth factor receptor is required for phosphorylation of Galpha(s).	EGFR GNAS	5.63e-06	2	83	2	11185568
Pubmed	Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism.	VWF ADAMTS13	5.63e-06	2	83	2	36736832
Pubmed	Human alpha 1(III) and alpha 2(V) procollagen genes are located on the long arm of chromosome 2.	COL3A1 COL5A2	5.63e-06	2	83	2	3858826
Pubmed	Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity.	VWF ADAMTS13	5.63e-06	2	83	2	32441353
Pubmed	The p.R1819_C1948delinsS mutation makes von Willebrand factor ADAMTS13-resistant and reduces its collagen-binding capacity.	VWF ADAMTS13	5.63e-06	2	83	2	25904363
Pubmed	ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.	VWF ADAMTS13	5.63e-06	2	83	2	12775718
Pubmed	Altered von Willebrand Factor and ADAMTS13 Levels in Children With Cirrhosis and Extrahepatic Portal Hypertension.	VWF ADAMTS13	5.63e-06	2	83	2	33369998
Pubmed	Effects of collagen deposition on passive and active mechanical properties of large pulmonary arteries in hypoxic pulmonary hypertension.	COL3A1 COL1A1	5.63e-06	2	83	2	23377784
Pubmed	Decreased von Willebrand factor ristocetin cofactor activity and increased ADAMTS13 antigen increase postoperative drainage after coronary artery bypass grafting.	VWF ADAMTS13	5.63e-06	2	83	2	24351199
Pubmed	Disulfide bond reduction of von Willebrand factor by ADAMTS-13.	VWF ADAMTS13	5.63e-06	2	83	2	20946172
Pubmed	Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors.	COL3A1 COL1A1	5.63e-06	2	83	2	25432063
Pubmed	Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly.	COL5A2 COL1A1	5.63e-06	2	83	2	7704020
Pubmed	Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.	EGFR SRC	5.63e-06	2	83	2	17804738
Pubmed	The Von Willebrand Factor A1-Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype.	COL3A1 VWF	5.63e-06	2	83	2	27889474
Pubmed	Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?	VWF ADAMTS13	5.63e-06	2	83	2	16203734
Pubmed	ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery.	VWF ADAMTS13	5.63e-06	2	83	2	28428179
Pubmed	Identification of ADAMTS13 peptide sequences binding to von Willebrand factor.	VWF ADAMTS13	5.63e-06	2	83	2	19944670
Pubmed	ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals.	VWF ADAMTS13	5.63e-06	2	83	2	18983500
Pubmed	Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.	VWF ADAMTS13	5.63e-06	2	83	2	25782102
Pubmed	Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men.	VWF ADAMTS13	5.63e-06	2	83	2	30745808
Pubmed	TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR.	EGFR SRC	5.63e-06	2	83	2	17849451
Pubmed	Activity of Von Willebrand factor and levels of VWF-cleaving protease (ADAMTS13) in preterm and full term neonates.	VWF ADAMTS13	5.63e-06	2	83	2	28087247
Pubmed	ADAMTS-13-VWF axis in sickle cell disease patients.	VWF ADAMTS13	5.63e-06	2	83	2	33404693
Pubmed	Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.	SRC GNAS	5.63e-06	2	83	2	38097740
Pubmed	[Emodin inhibits the proliferation, transdifferentiation and collagen synthesis of pulmonary fibroblasts].	COL3A1 COL1A1	5.63e-06	2	83	2	27363273
Pubmed	A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.	VWF ADAMTS13	5.63e-06	2	83	2	19587373
Pubmed	Molecular mapping of the chloride-binding site in von Willebrand factor (VWF): energetics and conformational effects on the VWF/ADAMTS-13 interaction.	VWF ADAMTS13	5.63e-06	2	83	2	16899464
Pubmed	Blood group antigen A on von Willebrand factor is more protective against ADAMTS13 cleavage than antigens B and H.	VWF ADAMTS13	5.63e-06	2	83	2	30929293
Pubmed	Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction.	VWF ADAMTS13	5.63e-06	2	83	2	25916953
Interaction	MATK interactions	EGFR SRC EWSR1 CYFIP2 PTK6	8.40e-07	43	82	5	int:MATK
Interaction	VWF interactions	COL3A1 VWF ADAMTS13 COL1A1	8.39e-06	32	82	4	int:VWF
Interaction	COL1A2 interactions	COL3A1 COL5A2 VWF EGFR COL1A1	1.65e-05	78	82	5	int:COL1A2
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFHR2 CFHR5 CRB1	3.50e-04	75	83	3	chr1q31
Cytoband	1q31.3	CFHR2 CFHR5	3.81e-04	16	83	2	1q31.3
Cytoband	20q13.3	GNAS PTK6	6.01e-04	20	83	2	20q13.3
Cytoband	1p22.3	SYDE2 DNAI3	7.29e-04	22	83	2	1p22.3
Cytoband	2q11.1	TRIM43B TRIM43	1.18e-03	28	83	2	2q11.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9p22	ZDHHC21 ADAMTSL1	4.19e-03	53	83	2	chr9p22
Cytoband	22q12.2	RNF185 EWSR1	5.00e-03	58	83	2	22q12.2
GeneFamily	Complement system\|Sushi domain containing	CFHR2 CFHR5 C6 CR1 CR1L	1.29e-07	36	61	5	492
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS19 ADAMTS3 ADAMTS9 ADAMTS13	4.38e-07	19	61	4	50
GeneFamily	ADAMTS like	ADAMTSL1 ADAMTSL3 ADAMTSL2	1.27e-06	7	61	3	947
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR2 CFHR5 C6 CR1 CR1L	1.35e-06	57	61	5	1179
GeneFamily	Collagens	COL3A1 COL5A2 COL1A1	5.00e-04	46	61	3	490
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	RBM5 EWSR1	2.26e-03	21	61	2	89
GeneFamily	Ring finger proteins	TRIM43B TRIM75 RNF185 TRAIP TRIM43	2.33e-03	275	61	5	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM43B TRIM75 TRIM43	4.06e-03	95	61	3	59
Coexpression	NABA_MATRISOME	COL3A1 CCN4 ADAMTS19 COL5A2 LAMB4 ADAMTSL1 VWF HMCN1 ADAMTS3 ADAMTS9 WNT6 CLEC4G LTBP2 ADAMTS13 PLG ADAMTSL3 MUC2 SSPOP ADAMTSL2 COL1A1	3.69e-11	1026	82	20	M5889
Coexpression	NABA_MATRISOME	COL3A1 CCN4 ADAMTS19 COL5A2 ADAMTSL1 VWF HMCN1 ADAMTS3 ADAMTS9 WNT6 CLEC4G LTBP2 ADAMTS13 PLG ADAMTSL3 MUC2 SSPOP ADAMTSL2 COL1A1	2.19e-10	1008	82	19	MM17056
Coexpression	NABA_CORE_MATRISOME	COL3A1 CCN4 COL5A2 LAMB4 VWF HMCN1 LTBP2 SSPOP COL1A1	2.03e-07	275	82	9	M5884
Coexpression	NABA_ECM_REGULATORS	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 PLG ADAMTSL3 ADAMTSL2	8.21e-07	238	82	8	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 ADAMTS13 PLG ADAMTSL3 ADAMTSL2	9.31e-07	242	82	8	MM17062
Coexpression	NABA_MATRISOME_METASTATIC_LUNG_LYMPH_NODE_METASTASIS	COL3A1 COL5A2 LTBP2 COL1A1	1.99e-06	29	82	4	MM17055
Coexpression	NABA_CORE_MATRISOME	COL3A1 CCN4 COL5A2 VWF HMCN1 LTBP2 SSPOP COL1A1	2.11e-06	270	82	8	MM17057
Coexpression	VANHARANTA_UTERINE_FIBROID_UP	COL3A1 COL5A2 LTBP2 COL1A1	1.10e-05	44	82	4	M18274
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 WNT6 CLEC4G ADAMTS13 PLG ADAMTSL3 MUC2 ADAMTSL2	1.86e-05	738	82	11	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS19 ADAMTSL1 ADAMTS3 ADAMTS9 WNT6 CLEC4G ADAMTS13 PLG ADAMTSL3 MUC2 ADAMTSL2	2.19e-05	751	82	11	M5885
Coexpression	THUM_MIR21_TARGETS_HEART_DISEASE_UP	COL5A2 LTBP2 COL1A1	2.33e-05	18	82	3	MM1241
Coexpression	THUM_MIR21_TARGETS_HEART_DISEASE_UP	COL5A2 LTBP2 COL1A1	2.33e-05	18	82	3	M13796
Coexpression	NABA_ECM_GLYCOPROTEINS	CCN4 LAMB4 VWF HMCN1 LTBP2 SSPOP	3.54e-05	196	82	6	M3008
Coexpression	POMEROY_MEDULLOBLASTOMA_DESMOPLASIC_VS_CLASSIC_DN	COL3A1 CYFIP1 LTBP2 COL1A1	4.05e-05	61	82	4	M8510
Coexpression	PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP	COL3A1 CCN4 CYFIP1 VWF ADAMTS9 COL1A1	5.33e-05	211	82	6	M12225
Coexpression	TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP	COL3A1 CCN4 COL5A2 COL1A1	6.59e-05	69	82	4	M10165
Coexpression	TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN	COL3A1 CCN4 COL5A2 COL1A1	8.67e-05	74	82	4	M13547
Coexpression	MENON_FETAL_KIDNEY_3_STROMAL_CELLS	COL3A1 COL5A2 GNAS COL1A1	1.23e-04	81	82	4	M39253
Coexpression	DESCARTES_FETAL_ADRENAL_STROMAL_CELLS	COL3A1 CCN4 C6 ADAMTSL3 COL1A1	1.32e-04	156	82	5	M40151
Coexpression	HAY_BONE_MARROW_STROMAL	COL3A1 COL5A2 KRTAP13-4 EGFR ADAMTS9 SPRY4 LTBP2 LY6K ADAMTSL3 COL1A1	1.39e-04	767	82	10	M39209
Coexpression	VERHAAK_GLIOBLASTOMA_CLASSICAL	EPHB4 EGFR SIPA1L1 GNAS ZNF606	1.53e-04	161	82	5	M2121
Coexpression	BOQUEST_STEM_CELL_UP	COL3A1 COL5A2 EGFR LTBP2 C6 COL1A1	1.71e-04	261	82	6	M1834
Coexpression	NABA_MATRISOME_PRIMARY_METASTATIC_LUNG_TUMOR	COL3A1 LTBP2 COL1A1	1.80e-04	35	82	3	MM17054
Coexpression	CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN	COL3A1 COL5A2 LTBP2	1.80e-04	35	82	3	M11788
Coexpression	MEBARKI_HCC_PROGENITOR_WNT_UP_CTNNB1_DEPENDENT	COL3A1 COL5A2 HMCN1 COL1A1	1.85e-04	90	82	4	M38984
Coexpression	CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN	COL3A1 COL5A2 LTBP2	1.96e-04	36	82	3	MM1212
Coexpression	HU_FETAL_RETINA_FIBROBLAST	COL3A1 EPHB4 COL5A2 CYFIP1 HMCN1 EGFR COL1A1	2.06e-04	385	82	7	M39264
Coexpression	NABA_MATRISOME_POORLY_METASTATIC_MELANOMA	ADAMTSL1 LTBP2 PLG	2.30e-04	38	82	3	M47982
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	COL3A1 COL5A2 ADAMTSL1 HMCN1 FHOD3 LTBP2 ADAMTS13 ADAMTSL2 COL1A1	1.28e-10	198	83	9	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	metastatic_Lymph_Node-Fibroblasts-Myofibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COL3A1 CCN4 COL5A2 LAMB4 HMCN1 LTBP2 ADAMTSL2 COL1A1	2.74e-09	191	83	8	aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	2.80e-08	167	83	7	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	4.02e-08	176	83	7	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	4.02e-08	176	83	7	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	COL3A1 COL5A2 VWF EGFR LTBP2 ADAMTSL3 COL1A1	7.29e-08	192	83	7	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	TCGA-Blood_and_Bone_Marrow-Primary_Tumor-Diffuse_large_B-cell_lymphoma-DLBCL-1\|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9	COL3A1 CCN4 COL5A2 TNFRSF9 EGFR LTBP2 COL1A1	7.83e-08	194	83	7	eaeeb84576270cc3fc59002ba33bff9639bb0b02
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTS3 ADAMTSL3 ADAMTSL2 COL1A1	8.11e-08	195	83	7	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL1 EGFR ADAMTSL2 COL1A1	8.69e-08	197	83	7	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	8.99e-08	198	83	7	7d2fe57e0f9311ac1e6854402ebc154306eb1ba5
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	9.63e-08	200	83	7	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL3A1 CCN4 COL5A2 DPPA2 LTBP2 COL1A1	4.96e-07	157	83	6	f147e24f2ece82e1c54750868954d09b3c461804
ToppCell	Children_(3_yrs)-Mesenchymal-chondrocyte-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL3A1 CCN4 COL5A2 DPPA2 LTBP2 COL1A1	5.15e-07	158	83	6	e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 COL5A2 EGFR RTN4R SLITRK4 COL1A1	6.64e-07	165	83	6	4e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 COL5A2 EGFR RTN4R SLITRK4 COL1A1	7.12e-07	167	83	6	fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 ADAMTS19 COL5A2 USP13 MAPKBP1 COL1A1	7.90e-07	170	83	6	8465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell	-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	COL3A1 COL5A2 LAMB4 LTBP2 ADAMTSL2 COL1A1	8.75e-07	173	83	6	88be9182fbb1bc83531cd41e59ea57c112a21d54
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL3A1 ADAMTS13 CR1L ADAMTSL3 ADAMTSL2 COL1A1	1.00e-06	177	83	6	ac90e4ce5be304a5a7473736397327010f2d1999
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	COL3A1 CCN4 COL5A2 ADAMTSL1 HMCN1 COL1A1	1.03e-06	178	83	6	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	356C-Fibroblasts-Fibroblast-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL3A1 COL5A2 ADAMTSL1 ADAMTS3 ADAMTSL2 COL1A1	1.03e-06	178	83	6	a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell	356C-Fibroblasts-Fibroblast-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL3A1 COL5A2 ADAMTSL1 ADAMTS3 ADAMTSL2 COL1A1	1.03e-06	178	83	6	371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CCN4 COL5A2 ADAMTSL1 WNT6 COL1A1	1.14e-06	181	83	6	269b39ac65790061d54eab47a8eeb024403f0348
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CCN4 COL5A2 ADAMTSL1 WNT6 COL1A1	1.14e-06	181	83	6	cd4f744b6b64ba6c22ec07afd1d3058a2546909d
ToppCell	facs-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CCN4 COL5A2 ADAMTSL1 WNT6 COL1A1	1.14e-06	181	83	6	c8395ae872aa80b3ae1ab7c53e57b3ca15aeb0e2
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL3 COL1A1	1.14e-06	181	83	6	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 ANKK1 ADAMTSL1 SLITRK4 CLEC4G COL1A1	1.21e-06	183	83	6	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.25e-06	184	83	6	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	COL3A1 COL5A2 ADAMTSL1 ADAMTSL3 ADAMTSL2 COL1A1	1.25e-06	184	83	6	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL3A1 CCN4 ADAMTS19 COL5A2 SPRY4 ADAMTSL3	1.25e-06	184	83	6	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.29e-06	185	83	6	87c416d14ca6255bee39b16e7571553e36ee3069
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	COL3A1 CCN4 COL5A2 ADAMTS9 ADAMTSL3 COL1A1	1.33e-06	186	83	6	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.33e-06	186	83	6	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 ADAMTSL2	1.38e-06	187	83	6	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 ADAMTSL1 DPPA2 ADAMTSL3 COL1A1	1.38e-06	187	83	6	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 ADAMTSL1 DPPA2 ADAMTSL3 COL1A1	1.38e-06	187	83	6	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 ADAMTSL1 DPPA2 ADAMTSL3 COL1A1	1.38e-06	187	83	6	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.38e-06	187	83	6	a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCell	-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	COL3A1 CCN4 COL5A2 LTBP2 ADAMTSL2 COL1A1	1.42e-06	188	83	6	038f48e8daaeb72716e975d22a6b004a90654960
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	COL3A1 COL5A2 ADAMTSL1 ADAMTS3 ADAMTSL3 COL1A1	1.42e-06	188	83	6	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	Fibroblast-C\|World / shred on cell class and cell subclass (v4)	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.46e-06	189	83	6	58e0400fbab5a0755504275aef5cf7986149abab
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	COL3A1 COL5A2 ADAMTSL1 ADAMTS3 ADAMTSL3 COL1A1	1.51e-06	190	83	6	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL3 COL1A1	1.51e-06	190	83	6	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 COL5A2 HMCN1 EGFR RTN4R COL1A1	1.56e-06	191	83	6	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL3A1 COL5A2 SRC FHOD3 LTBP2 COL1A1	1.56e-06	191	83	6	fd8331c7abdd999f55ba43d307945c6abfccbf84
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 COL5A2 HMCN1 EGFR RTN4R COL1A1	1.56e-06	191	83	6	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.56e-06	191	83	6	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	COL3A1 CCN4 COL5A2 ADAMTS9 ADAMTSL3 COL1A1	1.56e-06	191	83	6	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL1 ADAMTSL2 COL1A1	1.60e-06	192	83	6	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CFHR2 CCN4 ADAMTSL1 LTBP2 COL1A1	1.60e-06	192	83	6	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 EGFR ADAMTSL3 ADAMTSL2 COL1A1	1.60e-06	192	83	6	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL3 ADAMTSL2 COL1A1	1.60e-06	192	83	6	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.60e-06	192	83	6	67e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL1 ADAMTSL2 COL1A1	1.60e-06	192	83	6	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CFHR2 CCN4 ADAMTSL1 LTBP2 COL1A1	1.60e-06	192	83	6	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CFHR2 CCN4 ADAMTSL1 LTBP2 COL1A1	1.60e-06	192	83	6	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL3A1 ADAMTS19 COL5A2 ADAMTSL1 ADAMTSL3 COL1A1	1.60e-06	192	83	6	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 EGFR ADAMTSL3 ADAMTSL2 COL1A1	1.60e-06	192	83	6	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	COL3A1 ADAMTS19 COL5A2 ADAMTSL1 ADAMTSL3 COL1A1	1.60e-06	192	83	6	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CCN4 COL5A2 ADAMTSL1 EGFR COL1A1	1.65e-06	193	83	6	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 ADAMTSL1 HMCN1 ADAMTS3 COL1A1	1.65e-06	193	83	6	59b8186d0221fba06a16157e9d148399ed801f38
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 LTBP2 ADAMTSL2 COL1A1	1.65e-06	193	83	6	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CCN4 COL5A2 ADAMTSL1 EGFR COL1A1	1.65e-06	193	83	6	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL3A1 ADAMTSL1 EGFR TRIM43 ADAMTSL3 COL1A1	1.65e-06	193	83	6	64edc1d6fb0fe117767d494cf4a5723bf8be2804
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 ADAMTSL1 HMCN1 ADAMTS3 COL1A1	1.65e-06	193	83	6	dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL3A1 CCN4 ADAMTS19 COL5A2 ADAMTSL3 COL1A1	1.65e-06	193	83	6	adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.65e-06	193	83	6	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL3A1 ADAMTS19 COL5A2 ADAMTSL1 ADAMTSL3 COL1A1	1.65e-06	193	83	6	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	COL3A1 ADAMTS19 COL5A2 EGFR LTBP2 ADAMTSL3	1.65e-06	193	83	6	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 COL5A2 ADAMTSL1 HMCN1 ADAMTS3 COL1A1	1.65e-06	193	83	6	03678162648bd5b1d65a5450b60c8863edbf95c7
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.65e-06	193	83	6	5de87fc94a6e58899ef4124cf4887ed3ff96163a
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL3A1 CCN4 COL5A2 ADAMTSL1 EGFR COL1A1	1.65e-06	193	83	6	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 LTBP2 ADAMTSL2 COL1A1	1.65e-06	193	83	6	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TNFRSF9 HMCN1 CLEC4G LTBP2 CR1 CR1L	1.70e-06	194	83	6	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.70e-06	194	83	6	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.70e-06	194	83	6	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTS3 ADAMTSL3 COL1A1	1.70e-06	194	83	6	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 LTBP2 ADAMTSL2 COL1A1	1.70e-06	194	83	6	29f83cdd63314fff41258937d70b881a5503bfcc
ToppCell	Control-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.70e-06	194	83	6	3c2266772c5b56e8e02a461e5193e29588028ee9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL1 ADAMTSL2 COL1A1	1.70e-06	194	83	6	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	(5)_Fibroblast-C_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.70e-06	194	83	6	29a72e565c19407bbd198cfbc2a78106fe830d05
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 LTBP2 ADAMTSL2 COL1A1	1.70e-06	194	83	6	d3db241ea316bbcde6d16618193b474591ad5ce4
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.70e-06	194	83	6	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	Control-Stromal-Myofibroblast\|Control / Disease state, Lineage and Cell class	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.76e-06	195	83	6	ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL1 ADAMTSL2 COL1A1	1.76e-06	195	83	6	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 ADAMTSL1 ADAMTSL2 COL1A1	1.76e-06	195	83	6	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.76e-06	195	83	6	df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.76e-06	195	83	6	4243190ad291d56694e2155954dbaa879c9d3844
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.76e-06	195	83	6	51db90e7611f7d69980878c046505ff34212079b
ToppCell	COPD-Stromal-Myofibroblast\|COPD / Disease state, Lineage and Cell class	COL3A1 COL5A2 HMCN1 EGFR LTBP2 COL1A1	1.81e-06	196	83	6	af206bb5bbb8b604a6212acd79878bcc3d326cec
ToppCell	IPF-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	COL3A1 CFHR2 COL5A2 HMCN1 LTBP2 COL1A1	1.81e-06	196	83	6	7fc9894ceb79dab9f0495acc84e2d6d0d1c69bb7
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.81e-06	196	83	6	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.81e-06	196	83	6	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	PND10-Mesenchymal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.81e-06	196	83	6	ace167a40adb7022b365be3c2b1cbd4ba963739a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.81e-06	196	83	6	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.81e-06	196	83	6	42e9828222a9663525d571633e8a454c30bfa7f8
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL2 COL1A1	1.81e-06	196	83	6	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL3A1 COL5A2 HMCN1 LTBP2 ADAMTSL3 COL1A1	1.81e-06	196	83	6	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	COL3A1 CCN4 COL5A2 HMCN1 LTBP2 COL1A1	1.86e-06	197	83	6	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL3A1 CCN4 COL5A2 EGFR ADAMTSL2 COL1A1	1.86e-06	197	83	6	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	COPD-Stromal-Myofibroblast\|World / Disease state, Lineage and Cell class	COL3A1 COL5A2 HMCN1 EGFR LTBP2 COL1A1	1.86e-06	197	83	6	d51f484b4e01ac64233950d0b97fa88825ea1dbb
Computational	Neighborhood of CDH11	COL3A1 COL5A2 COL1A1	1.29e-04	25	43	3	GNF2_CDH11
Drug	Zinc Sulfate	PTCRA EGFR WNT6 SIPA1L1 SRC ANKIB1 NFXL1 BAZ1B GNAS CR1L MAP3K1 ADAMTSL2 COL1A1 DDX11	4.24e-07	739	83	14	ctd:D019287
Drug	NSC-270916	VWF EGFR ADAMTS13 CFHR5 PLG CR1L	5.48e-07	82	83	6	CID000002949
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A	LAMB4 PTCRA EGFR BAZ1B DGKQ LTBP2 HERC5	6.80e-06	193	83	7	4410_DN
Drug	estradiol, USP; Down 200; 0.01uM; ssMCF7; HG-U133A	CCN4 CD38 RBM5 UBIAD1 GNAS MUC2 PTK6	7.27e-06	195	83	7	414_DN
Drug	Pivampicillin [33817-20-8]; Up 200; 8.6uM; HL60; HT_HG-U133A	EPHB4 TNFRSF9 PTCRA TRAIP SRC KLHL18 CYFIP2	7.77e-06	197	83	7	2945_UP
Drug	Factor Xiiib	CFHR2 CFHR5 C6 PLG	7.89e-06	35	83	4	CID000126166
Drug	Alfaxalone [23930-19-0]; Down 200; 12uM; MCF7; HT_HG-U133A	TRAIP SIPA1L1 MCF2L CR1 HERC5 PTK6 COL1A1	8.03e-06	198	83	7	5451_DN
Drug	N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE	EGFR SRC	1.31e-05	2	83	2	DB07662
Drug	PD173952	VWF EGFR SRC	2.06e-05	15	83	3	CID005328733
Drug	Sodium, Dietary	COL3A1 CD38 COL1A1	2.53e-05	16	83	3	ctd:D012982
Drug	Rgd Peptide	COL3A1 LAMB4 VWF RTN4R SRC PLG COL1A1	2.71e-05	239	83	7	CID000104802
Drug	AC1MHG1S	VWF PLG	3.93e-05	3	83	2	CID003025825
Drug	CI-1033	EPHB4 EGFR EWSR1 PTK6	4.20e-05	53	83	4	CID000156413
Drug	Maprotiline hydrochloride [10347-81-6]; Up 200; 12.8uM; MCF7; HT_HG-U133A	COL5A2 PTCRA EGFR LTBP2 ADAMTS13 MAP3K1	7.32e-05	192	83	6	3236_UP
Drug	benzamidine	EGFR SRC	7.84e-05	4	83	2	ctd:C032157
Drug	Collagenase	COL3A1 COL1A1	7.84e-05	4	83	2	DB00048
Drug	EGFR/ErbB2 inhibitor	VWF EGFR	7.84e-05	4	83	2	CID009843206
Drug	(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline	EGFR SRC	7.84e-05	4	83	2	ctd:C575425
Drug	DO 897/99; Up 200; 8.2uM; MCF7; HT_HG-U133A	COL3A1 CFHR2 CCN4 PTCRA HERC5 COL1A1	8.21e-05	196	83	6	2877_UP
Drug	PF-00539758-00 [351321-34-1]; Up 200; 10uM; MCF7; HT_HG-U133A	COL3A1 COL5A2 PTCRA EGFR CR1 COL1A1	8.21e-05	196	83	6	6416_UP
Drug	Nomifensine maleate [32795-47-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A	COL5A2 LAMB4 BAZ1B GNAS PLG COL1A1	8.44e-05	197	83	6	7217_UP
Drug	clofibrate; Down 200; 150uM; MCF7; HG-U133A	EGFR SIPA1L1 RBM5 BAZ1B MUC2 PTK6	8.44e-05	197	83	6	263_DN
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	EPHB4 TRAIP SRC MAPKBP1 MAP3K1 COL1A1	8.44e-05	197	83	6	6271_UP
Drug	Norfloxacin [70458-96-7]; Down 200; 12.6uM; MCF7; HT_HG-U133A	PTCRA EGFR BAZ1B LTBP2 ZNF606 COL1A1	8.44e-05	197	83	6	2253_DN
Drug	Ethamivan [304-84-7]; Up 200; 18uM; MCF7; HT_HG-U133A	COL5A2 SIPA1L1 RBM5 MAPKBP1 HERC5 PTK6	8.44e-05	197	83	6	2879_UP
Drug	Piretanide [55837-27-9]; Up 200; 11uM; MCF7; HT_HG-U133A	COL5A2 LAMB4 PTCRA ADAMTS13 PLG COL1A1	8.44e-05	197	83	6	3567_UP
Drug	Boldine [476-70-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	TRAIP SIPA1L1 MAPKBP1 MCF2L CYFIP2 PTK6	8.44e-05	197	83	6	2804_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Up 200; 30.8uM; HL60; HT_HG-U133A	COL3A1 LAMB4 PTCRA LTBP2 CYFIP2 COL1A1	8.44e-05	197	83	6	2718_UP
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	EGFR TRAIP SRC GNAS MAPKBP1 COL1A1	8.44e-05	197	83	6	6105_DN
Drug	Zidovudine, AZT [30516-87-1]; Up 200; 15uM; HL60; HG-U133A	EPHB4 PTCRA CIZ1 C6 MAPKBP1 CR1	8.68e-05	198	83	6	1595_UP
Drug	6-Furfurylaminopurine [525-79-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A	EPHB4 SRC GNAS MAPKBP1 HERC5 COL1A1	8.68e-05	198	83	6	6073_DN
Drug	Phenelzine sulfate [156-51-4]; Up 200; 17uM; MCF7; HT_HG-U133A	PTCRA TRAIP CIZ1 LTBP2 MUC2 KLHL18	8.68e-05	198	83	6	2319_UP
Drug	Ciprofibrate [52214-84-3]; Up 200; 13.8uM; MCF7; HT_HG-U133A	COL5A2 PTCRA EGFR ADAMTS13 CR1 COL1A1	8.92e-05	199	83	6	3561_UP
Drug	ponatinib	EPHB4 EGFR SRC PTK6	1.12e-04	68	83	4	ctd:C545373
Drug	3-quinolinecarbonitrile	EGFR SRC	1.30e-04	5	83	2	CID000093177
Drug	Saralasin	COL3A1 COL1A1	1.30e-04	5	83	2	ctd:D012504
Disease	Ehlers-Danlos syndrome	COL3A1 COL5A2 COL1A1	9.86e-07	8	78	3	cv:C0013720
Disease	CD209 antigen measurement	CLEC4G ADAMTS13 ADAMTSL2	6.33e-06	14	78	3	EFO_0008077
Disease	coagulation factor measurement	VWF CFHR5 MCF2L	1.96e-05	20	78	3	EFO_0004634
Disease	EHLERS-DANLOS SYNDROME, CLASSIC TYPE, 1	COL5A2 COL1A1	2.07e-05	3	78	2	C4552122
Disease	chromosome 15q11.2 deletion syndrome (implicated_via_orthology)	CYFIP1 CYFIP2	2.07e-05	3	78	2	DOID:0060393 (implicated_via_orthology)
Disease	Ehlers-Danlos Syndrome, Autosomal Dominant, Type Unspecified	COL5A2 COL1A1	2.07e-05	3	78	2	C0220679
Disease	osteonecrosis (is_marker_for)	VWF PLG	4.12e-05	4	78	2	DOID:10159 (is_marker_for)
Disease	Heart valve disease	C6 ADAMTSL2 COL1A1	4.42e-05	26	78	3	C0018824
Disease	complement factor H-related protein 2 measurement	CFHR2 CRB1 DDX11	6.18e-05	29	78	3	EFO_0600055
Disease	scoliosis (implicated_via_orthology)	ADAMTS9 SSPOP	6.86e-05	5	78	2	DOID:0060249 (implicated_via_orthology)
Disease	Ehlers-Danlos Syndrome	COL3A1 COL1A1	6.86e-05	5	78	2	C0013720
Disease	Complement deficiency disease	CFHR2 CFHR5 C6	9.16e-05	33	78	3	C0272242
Disease	aortic valve disease (implicated_via_orthology)	ADAMTS19 EGFR	1.03e-04	6	78	2	DOID:62 (implicated_via_orthology)
Disease	blood sedimentation	CR1 CR1L	1.44e-04	7	78	2	EFO_0004304
Disease	Autoimmune Lymphoproliferative Syndrome Type 2B	COL5A2 COL1A1	1.44e-04	7	78	2	C1846545
Disease	Nephronophthisis, familial juvenile	ADAMTS9 MAPKBP1	1.44e-04	7	78	2	C1855681
Disease	Rectal Neoplasms	EGFR MUC2	1.44e-04	7	78	2	C0034885
Disease	Bleeding tendency	COL5A2 COL1A1	1.44e-04	7	78	2	C1458140
Disease	Rectal Carcinoma	EGFR MUC2	1.44e-04	7	78	2	C0007113
Disease	Hypertensive disease	COL3A1 VWF GNAS PLG COL1A1	1.51e-04	190	78	5	C0020538
Disease	complement factor H-related protein 5 measurement	CFHR2 CFHR5 CRB1	1.89e-04	42	78	3	EFO_0008098
Disease	Ewings sarcoma	CIZ1 EWSR1	1.91e-04	8	78	2	C0553580
Disease	C3 glomerulopathy	CFHR2 CFHR5	2.45e-04	9	78	2	C4087273
Disease	Ehlers-Danlos syndrome (is_implicated_in)	COL3A1 COL5A2	2.45e-04	9	78	2	DOID:13359 (is_implicated_in)
Disease	Autosomal Recessive Polycystic Kidney Disease	EGFR SRC	2.45e-04	9	78	2	C0085548
Disease	bladder neck obstruction (biomarker_via_orthology)	COL3A1 COL1A1	2.45e-04	9	78	2	DOID:13948 (biomarker_via_orthology)
Disease	complement factor H-related protein 4 measurement	CFHR2 CFHR5 CRB1	3.00e-04	49	78	3	EFO_0600091
Disease	Brain hemorrhage	COL3A1 UBIAD1	3.06e-04	10	78	2	C0553692
Disease	pulmonary fibrosis (biomarker_via_orthology)	VWF EGFR COL1A1	3.18e-04	50	78	3	DOID:3770 (biomarker_via_orthology)
Disease	cortical surface area measurement, neuroimaging measurement	ADAMTS19 COL5A2 ADAMTS3 ADAMTS9 FBXL17	3.45e-04	227	78	5	EFO_0004346, EFO_0010736
Disease	breast carcinoma	COL5A2 TNFRSF9 EGFR SPRY4 ANKIB1 EWSR1 PLG KLHL18 MAP3K1 COL1A1	3.46e-04	1019	78	10	EFO_0000305
Disease	Nephrosclerosis	COL3A1 COL1A1	3.74e-04	11	78	2	C0027719
Disease	pneumococcal bacteremia	CCN4 LAMB4	3.74e-04	11	78	2	EFO_1001925
Disease	hemopexin measurement	CFHR5 CRB1	3.74e-04	11	78	2	EFO_0008149
Disease	Aortic Valve Insufficiency	COL3A1 COL1A1	3.74e-04	11	78	2	C0003504
Disease	systemic scleroderma (is_marker_for)	VWF ADAMTS13 COL1A1	3.78e-04	53	78	3	DOID:418 (is_marker_for)
Disease	Familial thoracic aortic aneurysm and aortic dissection	COL3A1 COL5A2 COL1A1	3.78e-04	53	78	3	C4707243
Disease	complement factor H-related protein 1 measurement	CFHR2 CFHR5 CRB1	4.45e-04	56	78	3	EFO_0600054
Disease	rheumatic heart disease (biomarker_via_orthology)	COL3A1 COL1A1	4.48e-04	12	78	2	DOID:0050827 (biomarker_via_orthology)
Disease	tyrosine-protein kinase receptor Tie-1, soluble measurement	ADAMTS13 ADAMTSL2	5.28e-04	13	78	2	EFO_0008312
Disease	brain measurement, neuroimaging measurement	CCN4 ADAMTS19 COL5A2 ADAMTS3 EGFR ADAMTS9 MAP3K1	6.34e-04	550	78	7	EFO_0004346, EFO_0004464
Disease	Williams-Beuren syndrome (implicated_via_orthology)	SRC BAZ1B	7.08e-04	15	78	2	DOID:1928 (implicated_via_orthology)
Disease	Blood Coagulation Disorders	COL5A2 COL1A1	8.08e-04	16	78	2	C0005779
Disease	cup-to-disc ratio measurement	ADAMTS19 ADAMTSL1 FHOD3 LTBP2 LY6K ADAMTSL3	9.81e-04	430	78	6	EFO_0006939
Disease	anthropometric measurement	ADAMTS3 FBXL17 LTBP2 ADAMTSL3	1.04e-03	168	78	4	EFO_0004302
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	VWF EGFR	1.15e-03	19	78	2	DOID:9744 (biomarker_via_orthology)
Disease	otosclerosis	SIPA1L1 FHOD3 LTBP2	1.31e-03	81	78	3	EFO_0004213
Disease	gastric ulcer	LY6K GNAS	1.40e-03	21	78	2	EFO_0009454
Disease	hair color	EPHB4 TNFRSF9 DNAI3 MAP3K1 DDX11	1.42e-03	311	78	5	EFO_0003924
Disease	waist-hip ratio	KLLN TNFRSF9 ADAMTS9 RNF185 TRAIP SPRY4 DGKQ LTBP2 MAPKBP1 ADAMTSL3	1.43e-03	1226	78	10	EFO_0004343
Disease	Intrahepatic Cholangiocarcinoma	EGFR GNAS	1.83e-03	24	78	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	EGFR GNAS	1.83e-03	24	78	2	C3805278
Disease	Left Ventricular Hypertrophy	COL3A1 COL1A1	1.99e-03	25	78	2	C0149721
Disease	Malignant neoplasm of breast	EPHB4 ADAMTS19 VWF EGFR ICAM5 SIPA1L1 SRC CFHR5 MAP3K1	2.08e-03	1074	78	9	C0006142
Disease	Cholangiocarcinoma	EGFR GNAS	2.15e-03	26	78	2	C0206698
Disease	Schizophrenia	COL3A1 ANKK1 CYFIP1 ADAMTS3 RTN4R GNAS PLG ADAMTSL3	2.30e-03	883	78	8	C0036341
Disease	Colorectal Carcinoma	COL3A1 TNFRSF9 EGFR ICAM5 SRC GNAS ADAMTSL3	2.57e-03	702	78	7	C0009402
Disease	Liver Cirrhosis	COL3A1 COL5A2 COL1A1	2.60e-03	103	78	3	C0023890
Disease	response to paliperidone, schizophrenia symptom severity measurement	ADAMTSL1 HMCN1 CR1 CR1L	2.61e-03	216	78	4	EFO_0007925, EFO_0007927

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRKQCPSRLNSPAWE	GNAS	36	P84996
WRTECNQCKAPKPEG	EWSR1	536	Q01844
WQCPACQPATARRNS	BAZ1B	1226	Q9UIG0
RCWDQDPKKRPCFLD	ANKK1	266	Q8NFD2
WVRDPRYREDPCKQC	FBXO34	621	Q9NWN3
ELCRLPPSSQACDAW	DGKQ	346	P52824
WCPTPGCDRAVRLTK	ANKIB1	421	Q9P2G1
WPEQESRLCNLRPCD	CCN4	246	O95388
ADCTICFWDIRPQKP	DNAI3	516	Q8IWG1
SRREVCQAVPCPARW	ADAMTS13	941	Q76LX8
QSCPDWRKDCSNNPV	CD38	171	P28907
PQIRKCNEQPCQTRW	ADAMTS19	966	Q8TE59
WRSCSRAIPQVKCNE	CYFIP1	86	Q7L576
CPAQAWCSRSALRAP	PTCRA	246	Q6ISU1
TFECQNPRRCKWTEP	LY6K	51	Q17RY6
PIPRRCSAKEWSCQL	NFXL1	296	Q6ZNB6
CWQKDRNARPRFPQV	EPHB4	856	P54760
IRRDNCSGQKPLLCW	LRRC25	126	Q8N386
ASQEWSSPKKPQCRR	KIAA1614	106	Q5VZ46
QPIACNRRDCPSRWM	ADAMTSL1	1536	Q8N6G6
LWLNCSTNCPRPERG	ICAM5	51	Q9UMF0
RPGNWRTATLCPKTC	MUC2	281	Q02817
TCRNGQWSEPPKCLD	CFHR2	191	P36980
ERKTCRNPACGPQWE	ADAMTSL2	676	Q86TH1
LAWCRQRNPNPSCAA	KLLN	96	B2CW77
WRSCSRAIPQVKCNE	CYFIP2	86	Q96F07
KPRRRVWSPECCQDP	DDX11	941	Q96FC9
SNPRPKFEDWLCNKC	RBM5	176	P52756
RNCQNKPCPVDGSWS	HMCN1	4576	Q96RW7
LTCWCRDPEQRPCFK	PTK6	421	Q13882
TFCCPESWNERDPIR	HERC5	976	Q9UII4
QIWPREPCDDVKSQC	SCYL3	546	Q8IZE3
WGPEPRDCVSCRNVS	EGFR	516	P00533
ESRRPCNRVPCPAQW	ADAMTS3	956	O15072
PWQACSKPCQGERKR	ADAMTS9	886	Q9P2N4
PIANCWERCRPMTTA	KLHL18	311	O94889
SKQETRECNWQRCPI	C6	66	P13671
QCQADDRWDPPLAKC	CR1	1951	P17927
NRPSQKRPRCCSWCR	FBXL17	11	Q9UF56
NKWEPELPSCSRVCQ	CR1L	276	Q2VPA4
VRPFDWPCKNNRRCR	FHOD3	901	Q2V2M9
RDIWKPAPCQICVCD	COL5A2	51	P05997
QLVRGACKPECNSWE	DEFB113	36	Q30KQ7
CKDGRWQSLPRCVES	CFHR5	431	Q9BXR6
TCRNKQWSEPPRCLD	CFHR5	491	Q9BXR6
AWSQQCALCPPRSSE	LTBP2	1616	Q14767
KPRSESLWRQCSDCP	MCF2L	731	O15068
CRLNPDSSWAPKRVA	MAPKBP1	1171	O60336
CERCKDFFQDAPWRP	LAMB4	306	A4D0S4
WEPASCQKSCYRPRT	KRTAP13-4	56	Q3LI77
DRDVWKPEPCQICVC	COL3A1	41	P02461
ERQKAWCCSTLPEPA	ESCO1	751	Q5FWF5
NLSSCVWEQCRPEEP	CD164L2	71	Q6UWJ8
VRKDWCESQPCQSRG	CRB1	671	P82279
PINKVCRDTLRDWCQ	DPPA2	91	Q7Z7J5
LWKQSQDSRPRPEPC	FAM83G	461	A6ND36
RNREPLICPLCRSKW	MAP3K1	481	Q13233
RLNDNPWVCDCRARP	RTN4R	256	Q9BZR6
VFSWEPTPRKNRVCC	SYDE2	746	Q5VT97
EDNPWNCSCDLLPLK	SLITRK4	211	Q8IW52
DLMCQCWRKEPEERP	SRC	496	P12931
ASPRTLPSCWVCNQE	SPRY4	171	Q9C004
RPCLCLSWEEAQSPA	TRIM43	36	Q96BQ3
CPRDKQWLDCAQGPA	SSPOP	3091	A2VEC9
NRSEDSVRPWTCPKC	SIPA1L1	316	O43166
KNYCRNPDRELRPWC	PLG	231	P00747
NKRWELCDIPRCTTP	PLG	251	P00747
PEGQWLCRRCLQSPS	BRPF1	311	P55201
RLQNNSCEPCPTSWL	CLEC4G	156	Q6UXB4
EDEEPPPRRWCNTCQ	CIZ1	646	Q9ULV3
DVWKPEPCRICVCDN	COL1A1	51	P02452
VSCWPRKRCFPGSQD	TMEM95	126	Q3KNT9
WASPENPCLINECVR	VWF	2521	P04275
PTKARRPSSAQQECW	TRIM75	371	A6NK02
NDQKRGICRPWTNCS	TNFRSF9	126	Q07011
CALRTCWQKLPPFRE	WNT6	231	Q9Y6F9
WLETRPNRQVCPVCK	RNF185	66	Q96GF1
CPEQDRLPQRSWRQK	UBIAD1	31	Q9Y5Z9
SNCCEDISRPRKPWQ	ZDHHC21	216	Q8IVQ6
RPCLCLSWEEAQSPA	TRIM43B	36	A6NCK2
CNRPCVWSRLLKPNS	ZNF22-AS1	36	Q5T742
PSGWKCARCDLRENL	USP13	206	Q92995
ACPQRTCPEWVRNLE	ZNF606	126	Q8WXB4
QWFETAPSRTCPQCR	TRAIP	36	Q9BWF2
EPCNIRDCPARWFTS	ADAMTSL3	1476	P82987