Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	failure of initiation of embryo turning	FURIN ANKRD11 PAGR1 SUFU	1.54e-05	56	38	4	MP:0004180
Domain	fn3	COL7A1 LRFN1 OBSCN ROBO3	9.21e-04	162	50	4	PF00041
Domain	-	COL7A1 COL28A1	1.05e-03	18	50	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	COL7A1 COL28A1	1.05e-03	18	50	2	IPR020901
Domain	BPTI_KUNITZ_2	COL7A1 COL28A1	1.17e-03	19	50	2	PS50279
Domain	Kunitz_BPTI	COL7A1 COL28A1	1.17e-03	19	50	2	PF00014
Domain	BPTI_KUNITZ_1	COL7A1 COL28A1	1.17e-03	19	50	2	PS00280
Domain	FN3	COL7A1 LRFN1 OBSCN ROBO3	1.50e-03	185	50	4	SM00060
Domain	Kunitz_BPTI	COL7A1 COL28A1	1.71e-03	23	50	2	IPR002223
Domain	FN3	COL7A1 LRFN1 OBSCN ROBO3	1.96e-03	199	50	4	PS50853
Domain	FN3_dom	COL7A1 LRFN1 OBSCN ROBO3	2.35e-03	209	50	4	IPR003961
Domain	FHA	AGGF1 KIF14	2.54e-03	28	50	2	SM00240
Domain	FHA_DOMAIN	AGGF1 KIF14	3.11e-03	31	50	2	PS50006
Domain	FHA	AGGF1 KIF14	3.11e-03	31	50	2	PF00498
Domain	FHA_dom	AGGF1 KIF14	4.18e-03	36	50	2	IPR000253
Domain	-	AGGF1 KIF14	4.18e-03	36	50	2	2.60.200.20
Pubmed	Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.	CANX TOR3A	2.02e-05	5	50	2	19651773
Pubmed	RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains.	PRRC2A VARS1	2.02e-05	5	50	2	8104833
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	MAGI2 FURIN CANX DDR2 MAP3K10 PLAT ADAMTS14 PFKM TOR3A VARS1	3.46e-05	1451	50	10	30550785
Pubmed	Regulation of Torsin ATPases by LAP1 and LULL1.	CANX TOR3A	5.64e-05	8	50	2	23569223
Pubmed	PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex.	PRRC2A VARS1	5.64e-05	8	50	2	1351875
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	INTS5 DNAH12 CANX PHRF1 KIF14 PRRC2A	7.62e-05	496	50	6	31343991
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ZFYVE28 REXO4 RNGTT COL28A1 NEXMIF CANX OBSCN	8.37e-05	736	50	7	29676528
Pubmed	P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.	PRRC2A VARS1	1.32e-04	12	50	2	7993390
Pubmed	Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.	PLAT NR1H2	1.32e-04	12	50	2	22027013
Pubmed	Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation.	HMX2 SUFU	1.32e-04	12	50	2	38602877
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MAGI2 CANX DBN1 ACSS2 PRRC2A	1.41e-04	347	50	5	17114649
Pubmed	Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.	PHRF1 CTLA4	2.10e-04	15	50	2	20881011
Pubmed	Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.	REXO4 PRRC2A	2.40e-04	16	50	2	20098615
Pubmed	Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.	PHRF1 CTLA4	2.40e-04	16	50	2	20848568
Pubmed	Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.	PLAT CTLA4	4.18e-04	21	50	2	1347472
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZFYVE28 PHRF1 OBSCN	4.22e-04	101	50	3	10997877
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	MAGI2 LRFN1	5.95e-04	25	50	2	27480238
Pubmed	Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.	CTLA4 ADAMTS14	6.44e-04	26	50	2	20378664
Pubmed	Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout.	CANX TLE6	8.02e-04	29	50	2	31330130
Pubmed	Human transcription factor protein interaction networks.	REXO4 NFATC4 CANX PAGR1 GIGYF1 DBN1 SUFU PRRC2A	9.19e-04	1429	50	8	35140242
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	INTS5 LRFN1 FURIN OBSCN ANKRD11 SUFU RAB11FIP3	9.72e-04	1105	50	7	35748872
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	KDM5B AGGF1	9.77e-04	32	50	2	14613977
Pubmed	NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.	KDM5B TLE6	9.77e-04	32	50	2	38060382
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	INTS5 REXO4 RNGTT PHRF1 ANKRD11 KIF14 PRRC2A VARS1	1.24e-03	1497	50	8	31527615
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	PRDM10 PRRC2A RAB11FIP3	1.25e-03	147	50	3	28977470
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	CENPP ANKRD11 TOR3A PRRC2A	1.33e-03	332	50	4	37433992
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	PRDM10 NFATC4 AGGF1 TOR3A SUFU VARS1	1.39e-03	857	50	6	25609649
GeneFamily	Fibronectin type III domain containing	COL7A1 LRFN1 OBSCN ROBO3	3.45e-04	160	38	4	555
Coexpression	GSE11367_CTRL_VS_IL17_TREATED_SMOOTH_MUSCLE_CELL_UP	OBSCN ADAMTS14 TOR3A SUFU PRRC2A	6.36e-06	137	50	5	M460
Disease	myoclonic-atonic epilepsy (implicated_via_orthology)	ROBO3 VARS1	5.19e-05	7	47	2	DOID:0060475 (implicated_via_orthology)
Disease	Headache, HbA1c measurement	DDR2 PFKM	5.12e-04	21	47	2	EFO_0004541, HP_0002315
Disease	osteoarthritis (is_implicated_in)	DDR2 ADAMTS14	9.14e-04	28	47	2	DOID:8398 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALDDLEFWDCGLPTP	MAMDC4	211	Q6UXC1
EPVPWADAFAGPEDD	ANKRD11	2116	Q6UB99
DSEDEDEDKIWPPCI	AGGF1	396	Q8N302
AGDECEPEWCDAEDP	ACSS2	296	Q9NR19
PLSPEDEGCPWAEEA	DENND1C	531	Q8IV53
ACEDPPAPWEEKSRV	CENPP	21	Q6IPU0
PSYDCLLDDPFDPAW	ADAMTS14	451	Q8WXS8
GEEPAEEDSEDWCVP	PAGR1	76	Q9BTK6
PLFSWTEEPEECGPA	RAB11FIP3	121	O75154
GDFEDPPEWVPDEAC	ZFYVE28	806	Q9HCC9
RGEDAFCDPEDEWEP	KIF14	1161	Q15058
FCDPEDEWEPDITDA	KIF14	1166	Q15058
LEECWDPDPHGRPDF	MAP3K10	336	Q02779
PPEECKENELPYGWE	MAGI2	341	Q86UL8
PEGFEEDKDGLPEWC	GIGYF1	281	O75420
PPLLPDWCFEDDEDE	RNGTT	186	O60942
WPEPEAAEGDEDKPT	HDGFL1	106	Q5TGJ6
AWCPEIPVEPDDLKE	DDR2	71	Q16832
FWSIPEEEFLCEPPL	LRFN1	286	Q9P244
ELDPDGCPWLVIADF	PINK1	371	Q9BXM7
PECPPDDDWEEHLCR	PFKM	231	P08237
SEEEEPDDGWKAPAC	HMX2	51	A2RU54
PVPDSVGKWECPFDE	DNAH12	1811	Q6ZR08
ECLDPPLQEVPVDEW	PHRF1	211	Q9P1Y6
SPPEPWDEEDGASCS	PHRF1	936	Q9P1Y6
ECPVFEPSWEEFADP	KDM5B	31	Q9UGL1
PEIDITCWDADPVPE	DBN1	626	Q16643
DGEDTDLDDWEPDPP	PRDM10	151	Q9NQV6
WRPPDFEEELADCTA	OBSCN	6011	Q5VST9
EDDKAPEPTWADDLP	COL28A1	1031	Q2UY09
GLPPEAWQEECPSDS	FURIN	761	P09958
PEAVKPDDWDEDAPA	CANX	296	P27824
PDDWDEDAPAKIPDE	CANX	301	P27824
EGWLDDEPEYVPDPD	CANX	321	P27824
VIDPEPCPDSDFLLW	CTLA4	151	P16410
EEYQDPEAPWDSDDP	COL7A1	2861	Q02388
PEAPWDSDDPCSLPL	COL7A1	2866	Q02388
PAPPTEEDIWFDDVD	REXO4	186	Q9GZR2
EEEEEPLPPCEAVRW	RUNDC1	26	Q96C34
YPEPSECSWKDPEAE	VARS1	1091	P26640
TFPWDEDPEEDGSPD	SULT2B1	306	O00204
FWDPPAEEGCDLQEI	SLBP	196	Q14493
EPPAALEDNPDAWGD	NFATC4	126	Q14934
LPVGSKEEDDDEWCP	NEXMIF	511	Q5QGS0
CSTDWVIPDPEEEPE	NR1H2	56	P55055
EDAADWAPALCPSPE	PRKY	21	O43930
PCKPPAPEDEDEAWR	PRRC2A	436	P48634
CPDAAGAELAWPPEE	INTS5	821	Q6P9B9
NVEEDFKPAPECWIP	C12orf29	106	Q8N999
LPPADLQLPDWTECE	PLAT	431	P00750
LEFSPEEWECLDPAQ	ZNF695	11	Q8IW36
EEELEGSSEPEEWCP	ROBO3	1101	Q96MS0
AKCAWDDLSRPPEDD	SUFU	271	Q9UMX1
DPWEDEDPAGLPESF	ZNF469	2896	Q96JG9
WPDDCDEDEEAATGP	TOR3A	71	Q9H497
PEDFEDAWKRPDALP	TLE6	251	Q9H808