Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	STK4 PIP4K2B ITPKC AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	5.93e-09	709	39	12	GO:0016773
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	STK4 PIP4K2B ITPKC AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3 POLR3G	1.30e-08	938	39	13	GO:0016772
GeneOntologyMolecularFunction	kinase activity	STK4 PIP4K2B ITPKC AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	1.36e-08	764	39	12	GO:0016301
GeneOntologyMolecularFunction	protein serine kinase activity	STK4 AKT3 ERN2 TRIO WNK1 WNK4 WNK2 RPS6KB1 DYRK3	2.57e-08	363	39	9	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	STK4 AKT3 ERN2 TRIO WNK1 WNK4 WNK2 RPS6KB1 DYRK3	1.49e-07	446	39	9	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	STK4 AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	1.61e-07	600	39	10	GO:0004672
GeneOntologyMolecularFunction	potassium channel inhibitor activity	WNK1 WNK4 WNK2	1.12e-06	11	39	3	GO:0019870
GeneOntologyMolecularFunction	ion channel inhibitor activity	WNK1 WNK4 WNK2	1.12e-04	48	39	3	GO:0008200
GeneOntologyMolecularFunction	channel inhibitor activity	WNK1 WNK4 WNK2	1.27e-04	50	39	3	GO:0016248
GeneOntologyMolecularFunction	transporter inhibitor activity	WNK1 WNK4 WNK2	1.34e-04	51	39	3	GO:0141110
GeneOntologyMolecularFunction	potassium channel regulator activity	WNK1 WNK4 WNK2	1.87e-04	57	39	3	GO:0015459
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	JADE1 MCM3AP	3.84e-04	15	39	2	GO:0010484
GeneOntologyMolecularFunction	N-acetyltransferase activity	JADE1 NAA15 MCM3AP	4.74e-04	78	39	3	GO:0008080
GeneOntologyMolecularFunction	histone modifying activity	KMT2A SETD2 JADE1 MCM3AP	1.01e-03	229	39	4	GO:0140993
GeneOntologyMolecularFunction	N-acyltransferase activity	JADE1 NAA15 MCM3AP	1.03e-03	102	39	3	GO:0016410
GeneOntologyMolecularFunction	acetyltransferase activity	JADE1 NAA15 MCM3AP	1.09e-03	104	39	3	GO:0016407
GeneOntologyMolecularFunction	magnesium ion binding	STK4 ERN2 WNK1 DYRK3	1.34e-03	247	39	4	GO:0000287
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2A SETD2	3.34e-03	44	39	2	GO:0140938
GeneOntologyMolecularFunction	protein serine/threonine/tyrosine kinase activity	RPS6KB1 DYRK3	3.80e-03	47	39	2	GO:0004712
GeneOntologyMolecularFunction	ion channel regulator activity	WNK1 WNK4 WNK2	3.87e-03	162	39	3	GO:0099106
GeneOntologyMolecularFunction	histone acetyltransferase activity	JADE1 MCM3AP	4.46e-03	51	39	2	GO:0004402
GeneOntologyMolecularFunction	channel regulator activity	WNK1 WNK4 WNK2	4.72e-03	174	39	3	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	WNK1 WNK4 WNK2	4.95e-03	177	39	3	GO:0141108
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	JADE1 MCM3AP	5.17e-03	55	39	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	JADE1 MCM3AP	6.13e-03	60	39	2	GO:0034212
GeneOntologyMolecularFunction	ribonucleoprotein complex binding	AGO2 NAA15 NCLN	7.53e-03	206	39	3	GO:0043021
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2A SETD2	7.81e-03	68	39	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2A SETD2	8.03e-03	69	39	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2A SETD2	8.48e-03	71	39	2	GO:0042054
GeneOntologyBiologicalProcess	positive regulation of potassium ion import across plasma membrane	WNK1 WNK4 WNK2	2.18e-07	7	39	3	GO:1903288
GeneOntologyBiologicalProcess	regulation of potassium ion import	WNK1 WNK4 WNK2	5.21e-07	9	39	3	GO:1903286
GeneOntologyBiologicalProcess	negative regulation of sodium ion transport	WNK1 WNK4 WNK2	9.39e-06	22	39	3	GO:0010766
GeneOntologyBiologicalProcess	blood vessel morphogenesis	STK4 AKT3 SETD2 AGO2 NAA15 MYO1E WNK1 PDGFRB NAXE	1.67e-05	817	39	9	GO:0048514
GeneOntologyBiologicalProcess	tube morphogenesis	STK4 AKT3 SETD2 AGO2 NAA15 MYO1E WNK1 PDGFRB NAXE WNK4	3.33e-05	1125	39	10	GO:0035239
GeneOntologyBiologicalProcess	negative regulation of pancreatic juice secretion	WNK1 WNK4	3.47e-05	5	39	2	GO:0090188
GeneOntologyBiologicalProcess	regulation of sodium ion transport	AKT3 WNK1 WNK4 WNK2	3.90e-05	101	39	4	GO:0002028
GeneOntologyBiologicalProcess	angiogenesis	STK4 AKT3 SETD2 AGO2 NAA15 WNK1 PDGFRB NAXE	4.44e-05	708	39	8	GO:0001525
GeneOntologyBiologicalProcess	blood vessel development	STK4 AKT3 SETD2 AGO2 NAA15 MYO1E WNK1 PDGFRB NAXE	4.59e-05	929	39	9	GO:0001568
GeneOntologyBiologicalProcess	cell migration involved in vasculogenesis	SETD2 PDGFRB	5.20e-05	6	39	2	GO:0035441
GeneOntologyBiologicalProcess	vasculature development	STK4 AKT3 SETD2 AGO2 NAA15 MYO1E WNK1 PDGFRB NAXE	6.36e-05	969	39	9	GO:0001944
GeneOntologyBiologicalProcess	peptidyl-amino acid modification	STK4 KMT2A AKT3 SETD2 NAA15 WNK1 PDGFRB RPS6KB1 DYRK3	6.73e-05	976	39	9	GO:0018193
GeneOntologyBiologicalProcess	positive regulation of potassium ion transmembrane transport	WNK1 WNK4 WNK2	6.82e-05	42	39	3	GO:1901381
GeneOntologyBiologicalProcess	membrane raft distribution	DOCK2 NAXE	7.27e-05	7	39	2	GO:0031580
GeneOntologyBiologicalProcess	membrane raft localization	DOCK2 NAXE	9.68e-05	8	39	2	GO:0051665
GeneOntologyBiologicalProcess	potassium ion import across plasma membrane	WNK1 WNK4 WNK2	1.22e-04	51	39	3	GO:1990573
GeneOntologyBiologicalProcess	regulation of pancreatic juice secretion	WNK1 WNK4	1.24e-04	9	39	2	GO:0090186
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	AKT3 WNK1 PDGFRB WNK4 WNK2	1.38e-04	266	39	5	GO:0043270
GeneOntologyBiologicalProcess	positive regulation of potassium ion transport	WNK1 WNK4 WNK2	1.45e-04	54	39	3	GO:0043268
GeneOntologyBiologicalProcess	regulation of mRNA export from nucleus	SETD2 WNK1	1.90e-04	11	39	2	GO:0010793
GeneOntologyBiologicalProcess	regulation of canonical Wnt signaling pathway	STK4 JADE1 WNK1 WNK2 NFKB1	1.91e-04	285	39	5	GO:0060828
GeneOntologyBiologicalProcess	tube development	STK4 AKT3 SETD2 AGO2 NAA15 MYO1E WNK1 PDGFRB NAXE WNK4	2.10e-04	1402	39	10	GO:0035295
GeneOntologyBiologicalProcess	circulatory system development	STK4 AKT3 SETD2 AGO2 NAA15 TENM4 MYO1E WNK1 PDGFRB NAXE	2.64e-04	1442	39	10	GO:0072359
GeneOntologyBiologicalProcess	regulation of ribonucleoprotein complex localization	SETD2 WNK1	2.68e-04	13	39	2	GO:2000197
GeneOntologyBiologicalProcess	peptidyl-serine phosphorylation	STK4 AKT3 WNK1 RPS6KB1 DYRK3	2.69e-04	307	39	5	GO:0018105
GeneOntologyBiologicalProcess	ribonucleoprotein complex localization	SETD2 WNK1	3.12e-04	14	39	2	GO:0071166
GeneOntologyBiologicalProcess	pancreatic juice secretion	WNK1 WNK4	3.12e-04	14	39	2	GO:0030157
GeneOntologyBiologicalProcess	peptidyl-serine modification	STK4 AKT3 WNK1 RPS6KB1 DYRK3	3.21e-04	319	39	5	GO:0018209
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	DOCK2 STK4 AKT3 SETD2 AGO2 NAA15 TENM4 WNK1 PDGFRB NAXE	3.31e-04	1483	39	10	GO:0048646
GeneOntologyBiologicalProcess	mRNA export from nucleus	SETD2 WNK1 MCM3AP	3.69e-04	74	39	3	GO:0006406
GeneOntologyBiologicalProcess	nuclear export	SETD2 MDN1 WNK1 MCM3AP	4.03e-04	185	39	4	GO:0051168
GeneOntologyBiologicalProcess	intracellular chloride ion homeostasis	WNK1 WNK4	4.11e-04	16	39	2	GO:0030644
GeneOntologyBiologicalProcess	canonical Wnt signaling pathway	STK4 JADE1 WNK1 WNK2 NFKB1	4.53e-04	344	39	5	GO:0060070
GeneOntologyBiologicalProcess	intracellular monoatomic anion homeostasis	WNK1 WNK4	4.65e-04	17	39	2	GO:0030002
GeneOntologyBiologicalProcess	regulation of RNA export from nucleus	SETD2 WNK1	4.65e-04	17	39	2	GO:0046831
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway	STK4 JADE1 WNK1 WNK2 NFKB1	6.15e-04	368	39	5	GO:0030111
GeneOntologyBiologicalProcess	regulation of nucleobase-containing compound transport	SETD2 WNK1	6.48e-04	20	39	2	GO:0032239
GeneOntologyBiologicalProcess	negative regulation of digestive system process	WNK1 WNK4	6.48e-04	20	39	2	GO:0060457
GeneOntologyBiologicalProcess	nuclear transport	STK4 SETD2 MDN1 WNK1 MCM3AP	6.94e-04	378	39	5	GO:0051169
GeneOntologyBiologicalProcess	nucleocytoplasmic transport	STK4 SETD2 MDN1 WNK1 MCM3AP	6.94e-04	378	39	5	GO:0006913
GeneOntologyBiologicalProcess	RNA export from nucleus	SETD2 WNK1 MCM3AP	7.91e-04	96	39	3	GO:0006405
GeneOntologyBiologicalProcess	regulation of potassium ion transmembrane transport	WNK1 WNK4 WNK2	8.15e-04	97	39	3	GO:1901379
GeneOntologyBiologicalProcess	chloride ion homeostasis	WNK1 WNK4	1.02e-03	25	39	2	GO:0055064
GeneOntologyBiologicalProcess	monoatomic anion homeostasis	WNK1 WNK4	1.28e-03	28	39	2	GO:0055081
GeneOntologyBiologicalProcess	peptidyl-threonine phosphorylation	AKT3 WNK1 DYRK3	1.33e-03	115	39	3	GO:0018107
GeneOntologyBiologicalProcess	membrane raft organization	DOCK2 NAXE	1.37e-03	29	39	2	GO:0031579
GeneOntologyBiologicalProcess	vasculogenesis	SETD2 MYO1E PDGFRB	1.44e-03	118	39	3	GO:0001570
GeneOntologyBiologicalProcess	peptidyl-lysine methylation	KMT2A SETD2	1.47e-03	30	39	2	GO:0018022
GeneOntologyBiologicalProcess	regulation of potassium ion transport	WNK1 WNK4 WNK2	1.54e-03	121	39	3	GO:0043266
GeneOntologyBiologicalProcess	positive regulation of canonical Wnt signaling pathway	WNK1 WNK2 NFKB1	1.54e-03	121	39	3	GO:0090263
GeneOntologyBiologicalProcess	protein insertion into ER membrane	NCLN WNK1	1.56e-03	31	39	2	GO:0045048
GeneOntologyBiologicalProcess	negative regulation of protein localization to plasma membrane	WNK1 WNK4	1.56e-03	31	39	2	GO:1903077
GeneOntologyBiologicalProcess	embryonic hemopoiesis	STK4 KMT2A	1.67e-03	32	39	2	GO:0035162
GeneOntologyBiologicalProcess	skeletal muscle adaptation	CMYA5 RPS6KB1	1.67e-03	32	39	2	GO:0043501
GeneOntologyBiologicalProcess	peptidyl-threonine modification	AKT3 WNK1 DYRK3	1.69e-03	125	39	3	GO:0018210
GeneOntologyBiologicalProcess	positive regulation of cell migration	STK4 AKT3 AGO2 WNK1 PDGFRB RPS6KB1	1.76e-03	691	39	6	GO:0030335
GeneOntologyBiologicalProcess	sodium ion transport	AKT3 WNK1 WNK4 WNK2	1.76e-03	275	39	4	GO:0006814
GeneOntologyBiologicalProcess	negative regulation of protein localization to cell periphery	WNK1 WNK4	1.77e-03	33	39	2	GO:1904376
GeneOntologyBiologicalProcess	coronary vasculature morphogenesis	SETD2 PDGFRB	1.88e-03	34	39	2	GO:0060977
GeneOntologyBiologicalProcess	post-embryonic development	KMT2A AGO2 MYO1E	2.11e-03	135	39	3	GO:0009791
GeneOntologyCellularComponent	nuclear body	STK4 ITPKC JADE1 NAA15 CMYA5 RUFY1 DYRK3 POLR3G	2.64e-04	903	40	8	GO:0016604
Domain	PROTEIN_KINASE_ATP	STK4 AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	2.45e-08	459	39	10	PS00107
Domain	Ser/Thr_kinase_AS	STK4 AKT3 ERN2 TRIO WNK1 WNK4 WNK2 RPS6KB1 DYRK3	3.94e-08	357	39	9	IPR008271
Domain	S_TKc	STK4 AKT3 ERN2 TRIO WNK1 WNK4 WNK2 RPS6KB1 DYRK3	4.13e-08	359	39	9	SM00220
Domain	PROTEIN_KINASE_ST	STK4 AKT3 ERN2 TRIO WNK1 WNK4 WNK2 RPS6KB1 DYRK3	4.43e-08	362	39	9	PS00108
Domain	Prot_kinase_dom	STK4 AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	4.44e-08	489	39	10	IPR000719
Domain	PROTEIN_KINASE_DOM	STK4 AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	4.79e-08	493	39	10	PS50011
Domain	Pkinase	STK4 AKT3 ERN2 TRIO WNK1 WNK4 WNK2 RPS6KB1 DYRK3	6.87e-08	381	39	9	PF00069
Domain	Kinase-like_dom	STK4 AKT3 ERN2 TRIO WNK1 PDGFRB WNK4 WNK2 RPS6KB1 DYRK3	1.16e-07	542	39	10	IPR011009
Domain	Kinase_OSR1/WNK_CCT	WNK1 WNK4 WNK2	1.68e-07	6	39	3	IPR024678
Domain	OSR1_C	WNK1 WNK4 WNK2	1.68e-07	6	39	3	PF12202
Domain	Post-SET_dom	KMT2A SETD2	5.01e-04	16	39	2	IPR003616
Domain	PostSET	KMT2A SETD2	5.01e-04	16	39	2	SM00508
Domain	POST_SET	KMT2A SETD2	5.01e-04	16	39	2	PS50868
Domain	EPHD	KMT2A JADE1	9.56e-04	22	39	2	PS51805
Domain	Protein_kinase_ATP_BS	STK4 AKT3 PDGFRB RPS6KB1 DYRK3	1.09e-03	379	39	5	IPR017441
Domain	Pkinase_C	AKT3 RPS6KB1	2.70e-03	37	39	2	IPR017892
Domain	SET	KMT2A SETD2	3.31e-03	41	39	2	PF00856
Domain	Pkinase_C	AKT3 RPS6KB1	3.47e-03	42	39	2	PF00433
Domain	Znf_FYVE_PHD	KMT2A JADE1 RUFY1	3.55e-03	147	39	3	IPR011011
Domain	SET	KMT2A SETD2	4.15e-03	46	39	2	SM00317
Domain	SET_dom	KMT2A SETD2	4.89e-03	50	39	2	IPR001214
Domain	SET	KMT2A SETD2	4.89e-03	50	39	2	PS50280
Domain	p53-like_TF_DNA-bd	MYRFL NFKB1	5.47e-03	53	39	2	IPR008967
Domain	AGC-kinase_C	AKT3 RPS6KB1	6.09e-03	56	39	2	IPR000961
Domain	AGC_KINASE_CTER	AKT3 RPS6KB1	6.09e-03	56	39	2	PS51285
Domain	S_TK_X	AKT3 RPS6KB1	6.09e-03	56	39	2	SM00133
Pathway	KEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY	AKT3 PDGFRB RPS6KB1	2.21e-06	13	29	3	M47398
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	DOCK2 PIP4K2B AKT3 RPS6KB1	4.21e-05	96	29	4	M16121
Pathway	WP_DISTAL_CONVOLUTED_TUBULE_1_DCT1_CELL	WNK1 WNK4	8.53e-05	7	29	2	MM15929
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	8.53e-05	7	29	2	M47407
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2A SETD2 NFKB1	1.12e-04	46	29	3	MM14933
Pathway	WP_MIRNA_REGULATION_OF_PROSTATE_CANCER_SIGNALING	AKT3 PDGFRB NFKB1	1.35e-04	49	29	3	M39683
Pathway	KEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	1.82e-04	10	29	2	M47400
Pathway	KEGG_ACUTE_MYELOID_LEUKEMIA	AKT3 NFKB1 RPS6KB1	2.13e-04	57	29	3	M19888
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	2.22e-04	11	29	2	M47403
Pathway	KEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	2.22e-04	11	29	2	M47484
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	2.22e-04	11	29	2	M47499
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339	AKT3 NFKB1	2.22e-04	11	29	2	M47791
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	2.22e-04	11	29	2	M47501
Pathway	WP_PLEURAL_MESOTHELIOMA	AKT3 SETD2 PDGFRB NFKB1 RPS6KB1 CDH18	2.28e-04	439	29	6	M42563
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	2.66e-04	12	29	2	M47393
Pathway	WP_ACUTE_MYELOID_LEUKEMIA	AKT3 NFKB1 RPS6KB1	3.59e-04	68	29	3	M48322
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT3 NFKB1	3.66e-04	14	29	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	AKT3 NFKB1	3.66e-04	14	29	2	M47536
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2A SETD2 NFKB1	3.91e-04	70	29	3	M27231
Pathway	KEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	4.22e-04	15	29	2	M47663
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2A SETD2 JADE1 NFKB1	4.28e-04	175	29	4	MM14941
Pathway	WP_RAS_SIGNALING	STK4 AKT3 PDGFRB NFKB1	5.17e-04	184	29	4	M39764
Pathway	WP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE	AKT3 PDGFRB RPS6KB1	6.67e-04	84	29	3	M39839
Pathway	WP_PANCREATIC_ADENOCARCINOMA_PATHWAY	AKT3 NFKB1 RPS6KB1	7.89e-04	89	29	3	M39732
Pathway	KEGG_PROSTATE_CANCER	AKT3 PDGFRB NFKB1	7.89e-04	89	29	3	M13191
Pathway	BIOCARTA_RAC1_PATHWAY	TRIO RPS6KB1	8.38e-04	21	29	2	M8601
Pathway	BIOCARTA_RAC1_PATHWAY	TRIO RPS6KB1	8.38e-04	21	29	2	MM1463
Pathway	WP_GNAQ_PATHWAYS_IN_PORTWINE_STAIN	TRIO NFKB1	8.38e-04	21	29	2	M48342
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	WNK1 WNK4 WNK2	1.31e-03	106	29	3	M27200
Pathway	WP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING	PDGFRB NFKB1 RPS6KB1	1.38e-03	108	29	3	M48078
Pathway	WP_MAPK_SIGNALING	STK4 AKT3 PDGFRB NFKB1	1.52e-03	246	29	4	M39597
Pathway	WP_BURN_WOUND_HEALING	TPT1 PDGFRB NFKB1	1.57e-03	113	29	3	M42571
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PIP4K2B AKT3 PDGFRB	1.57e-03	113	29	3	MM14783
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	PIP4K2B AKT3	1.60e-03	29	29	2	MM15340
Pathway	PID_S1P_S1P3_PATHWAY	AKT3 PDGFRB	1.60e-03	29	29	2	M55
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	PIP4K2B AKT3	1.72e-03	30	29	2	M27637
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PIP4K2B AKT3 PDGFRB	1.78e-03	118	29	3	M713
Pathway	WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS	AKT3 NFKB1 RPS6KB1	1.83e-03	119	29	3	M48309
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_PI3K_SIGNALING_PATHWAY	AKT3 RPS6KB1	1.83e-03	31	29	2	M47396
Pathway	KEGG_MEDICUS_REFERENCE_CCR2_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	AKT3 NFKB1	1.83e-03	31	29	2	M47540
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	AKT3 NFKB1	1.83e-03	31	29	2	M47541
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	NFKB1 RPS6KB1	1.83e-03	31	29	2	MM15818
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	STK4 AKT3 PDGFRB NFKB1	2.06e-03	267	29	4	M10792
Pathway	WP_RESISTIN_AS_A_REGULATOR_OF_INFLAMMATION	AKT3 NFKB1	2.07e-03	33	29	2	M39745
Pathway	PID_IL2_PI3K_PATHWAY	NFKB1 RPS6KB1	2.20e-03	34	29	2	M143
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2A SETD2 JADE1 NFKB1	2.20e-03	272	29	4	M29619
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	NFKB1 RPS6KB1	2.47e-03	36	29	2	M39569
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	AKT3 RPS6KB1	2.47e-03	36	29	2	M1315
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK1 WNK4 WNK2	5.63e-09	4	40	3	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK1 WNK4 WNK2	5.63e-09	4	40	3	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK1 WNK4 WNK2	5.63e-09	4	40	3	11498583
Pubmed	WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.	WNK1 WNK4 WNK2	2.81e-08	6	40	3	21733846
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK1 WNK4 WNK2	4.92e-08	7	40	3	20525693
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK1 WNK4 WNK2	7.86e-08	8	40	3	23838290
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK1 WNK4 WNK2	7.86e-08	8	40	3	23387299
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	STK4 KMT2A NAA15 MDN1 TRIO WNK1 CLMN SYDE2 WNK4	4.60e-07	861	40	9	36931259
Pubmed	Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets.	AKT3 AGO2	1.29e-06	2	40	2	23603119
Pubmed	SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.	KMT2A SETD2	1.29e-06	2	40	2	29249820
Pubmed	Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis.	PIP4K2B AKT3	1.29e-06	2	40	2	36982700
Pubmed	Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.	WNK1 WNK4	1.29e-06	2	40	2	21704025
Pubmed	WNK kinases regulate thiazide-sensitive Na-Cl cotransport.	WNK1 WNK4	1.29e-06	2	40	2	12671053
Pubmed	MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.	KMT2A SETD2	1.29e-06	2	40	2	29777171
Pubmed	Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.	WNK1 WNK4	1.29e-06	2	40	2	22294159
Pubmed	Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.	NFKB1 RPS6KB1	1.29e-06	2	40	2	19433583
Pubmed	Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.	WNK1 WNK4	1.29e-06	2	40	2	16899520
Pubmed	MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB.	KMT2A NFKB1	1.29e-06	2	40	2	22623725
Pubmed	WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.	WNK1 WNK4	1.29e-06	2	40	2	25113964
Pubmed	WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.	WNK1 WNK4	1.29e-06	2	40	2	16820787
Pubmed	Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.	WNK1 WNK4	1.29e-06	2	40	2	29846116
Pubmed	WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.	WNK1 WNK2	1.29e-06	2	40	2	35849656
Pubmed	Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.	STK4 AKT3 PDGFRB RPS6KB1 DYRK3	3.59e-06	203	40	5	19953087
Pubmed	Identification of functional cooperative mutations of SETD2 in human acute leukemia.	KMT2A SETD2	3.87e-06	3	40	2	24509477
Pubmed	WNK kinases influence TRPV4 channel function and localization.	WNK1 WNK4	3.87e-06	3	40	2	16403833
Pubmed	Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.	WNK1 WNK4	3.87e-06	3	40	2	29459793
Pubmed	N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.	TRIO PDGFRB	3.87e-06	3	40	2	30463880
Pubmed	Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.	WNK1 WNK4	3.87e-06	3	40	2	24821705
Pubmed	Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.	WNK1 WNK4	3.87e-06	3	40	2	29667910
Pubmed	Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.	WNK1 WNK2	3.87e-06	3	40	2	23797875
Pubmed	Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.	WNK1 WNK4	3.87e-06	3	40	2	16788137
Pubmed	AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).	KMT2A AFF4	3.87e-06	3	40	2	10588740
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	DOCK2 STK4 AKT3 PDGFRB NFKB1 RPS6KB1	4.00e-06	371	40	6	25241761
Pubmed	Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.	WNK1 WNK4	7.73e-06	4	40	2	23576762
Pubmed	Structural insights into the recognition of substrates and activators by the OSR1 kinase.	WNK1 WNK4	7.73e-06	4	40	2	17721439
Pubmed	PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.	PDGFRB RPS6KB1	7.73e-06	4	40	2	17599906
Pubmed	WNK4-SPAK modulates lipopolysaccharide-induced macrophage activation.	WNK4 NFKB1	7.73e-06	4	40	2	31786261
Pubmed	WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.	WNK1 WNK4	7.73e-06	4	40	2	16832045
Pubmed	MST1 modulates Th17 activation in psoriasis via regulating TLR4-NF-κB pathway.	STK4 NFKB1	7.73e-06	4	40	2	32930944
Pubmed	Pseudohypoaldosteronism Type II	WNK1 WNK4	7.73e-06	4	40	2	22073419
Pubmed	Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway.	AKT3 WNK1	7.73e-06	4	40	2	28389565
Pubmed	Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2.	WNK1 WNK4	7.73e-06	4	40	2	29392534
Pubmed	SLC26A9 is a Cl(-) channel regulated by the WNK kinases.	WNK1 WNK4	7.73e-06	4	40	2	17673510
Pubmed	Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.	WNK1 WNK4	1.29e-05	5	40	2	19008908
Pubmed	Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.	WNK1 WNK4	1.29e-05	5	40	2	24641320
Pubmed	Distinct roles for CARMIL isoforms in cell migration.	MYO1E TRIO	1.29e-05	5	40	2	19846667
Pubmed	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.	WNK1 WNK4	1.29e-05	5	40	2	34315884
Pubmed	WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID.	WNK1 WNK4	1.29e-05	5	40	2	33184430
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	STK4 KMT2A AKT3 WNK1 WNK4 WNK2 RPS6KB1	1.78e-05	730	40	7	34857952
Pubmed	Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation.	NFKB1 RPS6KB1	1.93e-05	6	40	2	23816567
Pubmed	Protein kinase B alpha/Akt1 regulates placental development and fetal growth.	AKT3 RPS6KB1	1.93e-05	6	40	2	12783884
Pubmed	Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.	NFKB1 RPS6KB1	2.70e-05	7	40	2	27053111
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JADE1 MDN1 NCLN MYO1E TRIO WNK1 WNK2 MCM3AP	3.15e-05	1105	40	8	35748872
Pubmed	Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts.	AKT3 RPS6KB1	3.60e-05	8	40	2	20040596
Pubmed	Receptor association and tyrosine phosphorylation of S6 kinases.	PDGFRB RPS6KB1	3.60e-05	8	40	2	16640565
Pubmed	WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.	WNK1 WNK4	3.60e-05	8	40	2	15350218
Pubmed	Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.	WNK1 WNK4	3.60e-05	8	40	2	26286618
Pubmed	IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.	WNK1 WNK4	3.60e-05	8	40	2	21317537
Pubmed	Tagging genes with cassette-exchange sites.	STK4 PIP4K2B AGO2 JADE1 NAA15	4.02e-05	335	40	5	15741177
Pubmed	Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders.	PDGFRB NFKB1	4.62e-05	9	40	2	25164676
Pubmed	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.	NFKB1 RPS6KB1	4.62e-05	9	40	2	21035469
Pubmed	Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.	AKT3 RPS6KB1	4.62e-05	9	40	2	16962829
Pubmed	Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways.	AKT3 NFKB1	4.62e-05	9	40	2	24225433
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	TPT1 ERN2 WNK1 NFKB1 MCM3AP	5.72e-05	361	40	5	18976975
Pubmed	A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.	KMT2A AFF4	5.77e-05	10	40	2	20153263
Pubmed	CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.	KMT2A AFF4	5.77e-05	10	40	2	22094252
Pubmed	TCTP is essential for β-cell proliferation and mass expansion during development and β-cell adaptation in response to insulin resistance.	TPT1 RPS6KB1	5.77e-05	10	40	2	24248465
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	KMT2A TPT1 SETD2 NAA15	5.85e-05	183	40	4	36129980
Pubmed	HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors.	AKT3 NFKB1	7.05e-05	11	40	2	24658403
Pubmed	MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2.	KMT2A SETD2	7.05e-05	11	40	2	31856871
Pubmed	A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.	TPT1 RPS6KB1	7.05e-05	11	40	2	17475776
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	STK4 KMT2A PIP4K2B AGO2 TRIO AFF4 RPS6KB1	7.20e-05	910	40	7	36736316
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	STK4 KMT2A SETD2 NAA15 WNK1 CLMN AFF4	8.47e-05	934	40	7	33916271
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	KMT2A TPT1 SETD2 AGO2 JADE1 WNK1 RUFY1 MCM3AP	1.14e-04	1327	40	8	32694731
Pubmed	HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.	AKT3 NFKB1	1.16e-04	14	40	2	24244375
Pubmed	MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.	KMT2A AFF4	1.16e-04	14	40	2	20854876
Pubmed	MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells.	NFKB1 RPS6KB1	1.16e-04	14	40	2	24349514
Pubmed	BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.	STK4 TXNL1 MDN1 NFKB1	1.32e-04	226	40	4	25900982
Pubmed	Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.	AKT3 RPS6KB1	1.34e-04	15	40	2	19850877
Pubmed	Identification of potential protein interactors of Lrrk2.	AGO2 MDN1	1.34e-04	15	40	2	17400507
Pubmed	PDGF signaling specificity is mediated through multiple immediate early genes.	MYO1E PDGFRB	1.73e-04	17	40	2	17143286
Pubmed	Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.	AKT3 NFKB1	1.73e-04	17	40	2	23251686
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	STK4 PIP4K2B SETD2 TRIO WNK1 CLMN	1.79e-04	733	40	6	34672954
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	TPT1 SETD2 MDN1 NFKB1	1.86e-04	247	40	4	32989298
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	STK4 KMT2A AGO2 TENM4 MYO1E TRIO CLMN WNK2	1.91e-04	1431	40	8	37142655
Pubmed	The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.	AKT3 RPS6KB1	1.95e-04	18	40	2	33514739
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	AGO2 NAA15 TENM4 TRIO CLMN	2.06e-04	475	40	5	31040226
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MDN1 NCLN MCM3AP	2.37e-04	104	40	3	31240132
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KMT2A MDN1 NCLN RUFY1 WNK4	2.54e-04	497	40	5	36774506
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TXNL1 PIP4K2B NAA15 TENM4 NCLN TRIO WNK2	2.87e-04	1139	40	7	36417873
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	DOCK2 KMT2A TPT1 AGO2 MDN1 RPS6KB1	3.00e-04	807	40	6	30575818
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	STK4 TENM4 MYO1E NFKB1 POLR3G	3.60e-04	536	40	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	STK4 TENM4 MYO1E NFKB1 POLR3G	3.66e-04	538	40	5	10512203
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	AKT3 SETD2	4.78e-04	28	40	2	24462114
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CWF19L2 SETD2 WNK1 RUFY1 MCM3AP	5.48e-04	588	40	5	38580884
Pubmed	T-Cell Signaling in HIV-1 Infection.	DOCK2 NFKB1	6.26e-04	32	40	2	23986795
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	PIP4K2B SETD2 JADE1 WNK1 WNK2	6.37e-04	608	40	5	16713569
Pubmed	α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.	TXNL1 CLMN	7.49e-04	35	40	2	37381005
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	AGO2 MDN1 TRIO WNK2 AFF4 RPS6KB1	7.62e-04	963	40	6	28671696
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	KMT2A COLGALT2 NAA15 NCLN RPS6KB1	8.60e-04	650	40	5	38777146
Interaction	SGK1 interactions	AKT3 WNK1 WNK4 WNK2 RPS6KB1	4.50e-07	80	39	5	int:SGK1
Interaction	CFAP184 interactions	STK4 CWF19L2 ITPKC SETD2 MCM3AP	1.46e-05	162	39	5	int:CFAP184
Interaction	RAC1 interactions	DOCK2 MDN1 NCLN MYO1E TRIO PDGFRB RUFY1 SYDE2 RPS6KB1 MCM3AP	2.50e-05	1063	39	10	int:RAC1
Interaction	EIF4EBP1 interactions	STK4 AKT3 AGO2 RPS6KB1	3.22e-05	94	39	4	int:EIF4EBP1
Interaction	KLHL3 interactions	WNK1 WNK4 WNK2	7.84e-05	43	39	3	int:KLHL3
Interaction	SGK2 interactions	TPT1 AKT3 RPS6KB1	7.84e-05	43	39	3	int:SGK2
Interaction	HSP90AB4P interactions	AKT3 AGO2 PDGFRB RUFY1	1.01e-04	126	39	4	int:HSP90AB4P
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2A SETD2	7.05e-04	34	21	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CADPS2 SYDE2	7.90e-04	36	21	2	823
GeneFamily	PHD finger proteins	KMT2A JADE1	4.84e-03	90	21	2	88
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TRIO PDGFRB	1.48e-02	161	21	2	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AKT3 CADPS2	2.35e-02	206	21	2	682
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPKC SETD2 AGO2 NAA15 WNK1 AFF4 NFKB1	2.95e-10	185	40	7	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ITPKC CMYA5 ERN2 WNK2 AFF4	5.54e-07	179	40	5	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	AKT3 COLGALT2 TENM4 PDGFRB CLMN	7.83e-07	192	40	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NCLN ERN2 WNK4 WNK2	1.81e-05	175	40	4	019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS2 WNK1 CLMN WNK4	1.98e-05	179	40	4	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2A TPT1 AKT3 RESP18	2.02e-05	180	40	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2A TPT1 AKT3 RESP18	2.02e-05	180	40	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS2 WNK1 CLMN WNK4	2.16e-05	183	40	4	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	ILEUM-inflamed-(5)_Plasma-(5)_IgA_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	STK4 KMT2A TPT1 CLMN	2.45e-05	189	40	4	a0634d72bfdd5f93877724ed6480b50a3a046f71
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	KMT2A WNK1 NAXE AFF4	2.82e-05	196	40	4	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPKC NAA15 WNK1 AFF4	2.82e-05	196	40	4	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	KMT2A AGO2 JADE1 WNK1	3.00e-05	199	40	4	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-gdT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK2 STK4 AKT3 COLGALT2	3.05e-05	200	40	4	1779a8ff4443a85ac500f849764e86d9c7529b84
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Club\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CMYA5 CADPS2 ERN2 WNK2	3.05e-05	200	40	4	292c63693eb7f435335a8cfba07aa35b72139393
ToppCell	droplet-Liver-Npc-21m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB MCM3AP POLR3G	3.57e-05	71	40	3	cf4c8715c2bd77fc86e45cc01bcc7aa6044e091d
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COLGALT2 AGO2 WNK2	1.83e-04	123	40	3	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	moderate-Epithelial-unknown_epithelial\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ITPKC ERN2 TRIO	2.57e-04	138	40	3	afefa8233c67aa744e939156bc538449bf6bd05b
ToppCell	Goblet-gob-2\|World / Class top	PIP4K2B CADPS2 SYDE2	2.79e-04	142	40	3	9b058dc313d1f0edcd8473e342852632e17536a6
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TENM4 WNK2 CDH18	3.15e-04	148	40	3	5983c4546f527a0b599cfcbd8a6cb937a1d6f895
ToppCell	normal_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	COLGALT2 AGO2 CC2D2B	3.21e-04	149	40	3	a34d095b8e0fe59d69d84e4fd2fe4ccb82f92e4f
ToppCell	RV-16._Neuronal\|RV / Chamber and Cluster_Paper	AKT3 CLMN POLR3G	3.47e-04	153	40	3	bed8bbf5c5cbfbf46a816066da472c3fdddecb5d
ToppCell	18-Airway-Epithelial-Goblet-like_secretory\|Airway / Age, Tissue, Lineage and Cell class	ERN2 CLMN WNK2	3.47e-04	153	40	3	14a60220e169ce642771636de982a7b02e5b2608
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CMYA5 CADPS2 WNK1	3.47e-04	153	40	3	79c4f4ccdc8249c8461075c73491bc3b2d13344a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB CLMN DYRK3	3.54e-04	154	40	3	b6e982e341c6cfb6ff80a318078fcb10c36d182f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB CLMN DYRK3	3.54e-04	154	40	3	d76fd51a4587decbfe1dde1c8a9b880c5fa18e4a
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIO SYDE2 WNK2	3.82e-04	158	40	3	12661763d1c309106801cb710c04cd2b62d16cba
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIO SYDE2 WNK2	3.82e-04	158	40	3	0792c39e6fc0745095af7812de2d50949540d60f
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIO SYDE2 WNK2	3.82e-04	158	40	3	e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CMYA5 CADPS2 WNK1	3.89e-04	159	40	3	50d951cf27a571c0c5002003c16fbc370fa17eb1
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETD2 RESP18 CDH18	4.03e-04	161	40	3	a7e74bc80ac11250e353e5614b19c05793fc2e95
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPKC CMYA5 WNK2	4.11e-04	162	40	3	593939be9d38690c89c31d4c58e351de26cbf9ab
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPKC CMYA5 WNK2	4.11e-04	162	40	3	3a61eda548afa2a41bdf6293d1050103dc210e52
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK2 ERN2 CDH18	4.18e-04	163	40	3	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS2 MYO1E WNK1	4.64e-04	169	40	3	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	AKT3 MYO1E CLMN	4.64e-04	169	40	3	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JADE1 CMYA5 WNK4	4.72e-04	170	40	3	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	facs-Trachea-18m-Hematologic-myeloid-granulocyte-granulocyte_l26\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK2 AGO2 DYRK3	4.72e-04	170	40	3	4b1c84b35b7242a297ffdb9c23a6d982acf1bed5
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	MYO1E PDGFRB CLMN	4.81e-04	171	40	3	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAA15 ERN2 WNK2	4.97e-04	173	40	3	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAA15 ERN2 WNK2	4.97e-04	173	40	3	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CADPS2 CLMN SYDE2	5.06e-04	174	40	3	ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	JADE1 PDGFRB CLMN	5.14e-04	175	40	3	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RESP18 MYRFL ERN2	5.14e-04	175	40	3	38dec78efc99fe23479cba68cfa441e62bd6a08b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKT3 CADPS2 CDH18	5.14e-04	175	40	3	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 RESP18 MYO1E	5.14e-04	175	40	3	5092c5159f697e20bf8aa450c414ffd997738d25
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 RESP18 MYO1E	5.14e-04	175	40	3	82482f3fc716701bed46dc65c2044577aed15427
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CADPS2 CLMN SYDE2	5.23e-04	176	40	3	40993c41c1017b53039a337174fc56632b278609
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-5_THEMIS_ELOF1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK2 CADPS2 PDGFRB	5.23e-04	176	40	3	78306517b1e52411a2ba72f141efea4d12c09f25
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STK4 SYDE2 NFKB1	5.31e-04	177	40	3	d34b086a5931d7f1737a504952d51c47693e91a8
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN2 WNK4 WNK2	5.40e-04	178	40	3	9099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	JADE1 PDGFRB CLMN	5.49e-04	179	40	3	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERN2 CLMN WNK4	5.49e-04	179	40	3	c833ded1f9e87be2ba2037820d92a389560b711c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CADPS2 PDGFRB CDH18	5.58e-04	180	40	3	fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 CADPS2 MYO1E	5.58e-04	180	40	3	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKT3 PDGFRB WNK2	5.58e-04	180	40	3	79c5725f02e038d0187f4a1e1591f2492538aa57
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CADPS2 ERN2 WNK2	5.58e-04	180	40	3	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS2 MYO1E WNK1	5.58e-04	180	40	3	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	AKT3 PDGFRB CLMN	5.76e-04	182	40	3	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	AKT3 TENM4 TRIO	5.76e-04	182	40	3	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COLGALT2 TENM4 PDGFRB	5.76e-04	182	40	3	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	MYO1E PDGFRB CLMN	5.85e-04	183	40	3	818fd886e0188091310825f9145fa53328f2c979
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WNK1 CLMN WNK4	5.85e-04	183	40	3	2f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCell	Pericytes-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	COLGALT2 MYRFL PDGFRB	5.85e-04	183	40	3	d04deef7cd4e1738227a6593b84874ce0168c773
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SETD2 TRIO AFF4	5.85e-04	183	40	3	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS2 WNK1 WNK4	5.85e-04	183	40	3	f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CMYA5 CADPS2 CDH18	5.95e-04	184	40	3	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3\|TCGA-Lung / Sample_Type by Project: Shred V9	COLGALT2 TENM4 WNK2	5.95e-04	184	40	3	ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TENM4 CADPS2 CDH18	5.95e-04	184	40	3	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS2 WNK1 WNK4	5.95e-04	184	40	3	8939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CMYA5 MYO1E PDGFRB	6.04e-04	185	40	3	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CMYA5 CADPS2 PDGFRB	6.04e-04	185	40	3	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CMYA5 MYO1E PDGFRB	6.04e-04	185	40	3	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	COVID_vent-Myeloid-Dendritic-cDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MYO1E TRIO NFKB1	6.14e-04	186	40	3	39457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 TENM4 CLMN	6.14e-04	186	40	3	1cbb1a1c4f0f6078e9c7b4e0dc93d6b6de7e57db
ToppCell	COPD-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	ITPKC ERN2 WNK2	6.14e-04	186	40	3	d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell	Tuft\|World / Class top	CADPS2 CLMN WNK2	6.14e-04	186	40	3	f4d83f15ab7b49c0920a322cd832413ece7c9948
ToppCell	COVID_vent-Myeloid-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MYO1E TRIO NFKB1	6.14e-04	186	40	3	63a5cdd3f60681762a218be32db84be8f29b88fd
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TENM4 CADPS2 CDH18	6.14e-04	186	40	3	e83718fabb057100835d3357df407f283d23fe16
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	COLGALT2 PDGFRB CLMN	6.14e-04	186	40	3	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	Tuft-tuft-2\|World / Class top	CADPS2 CLMN WNK2	6.23e-04	187	40	3	4ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDGFRB CLMN WNK2	6.23e-04	187	40	3	86250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCell	COVID-19-kidney-Mito-rich_Distal\|kidney / Disease (COVID-19 only), tissue and cell type	TENM4 CLMN WNK4	6.23e-04	187	40	3	2ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 CADPS2 MYO1E	6.23e-04	187	40	3	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	STK4 TRIO PDGFRB	6.33e-04	188	40	3	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS2 WNK1 WNK4	6.33e-04	188	40	3	d2d2b6c49448da24f457cedcd213f68841834a99
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 CADPS2 MYO1E	6.33e-04	188	40	3	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS2 WNK1 WNK4	6.33e-04	188	40	3	ab6fa1beff91584d9303c2a33735de89aae8d5cd
ToppCell	COVID-19-kidney-DCT\|kidney / Disease (COVID-19 only), tissue and cell type	WNK1 CLMN WNK4	6.33e-04	188	40	3	df1fd0819d301679f3c9ea404e942e39095912eb
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS2 WNK1 WNK4	6.43e-04	189	40	3	ff637ae0afdb1fdc67451be7e1e4fe575fbcfff4
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CADPS2 WNK1 WNK4	6.43e-04	189	40	3	e127e3be626bc513e151d41812f0b7adb89d5da6
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 NFKB1	6.49e-04	42	40	2	56bbec86001d43cc2c71d4dcd70b22ea41963fad
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 CADPS2 MYO1E	6.53e-04	190	40	3	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	DOCK2 STK4 AKT3	6.53e-04	190	40	3	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TPT1 JADE1 AFF4	6.53e-04	190	40	3	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TENM4 CLMN WNK4	6.53e-04	190	40	3	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AKT3 CADPS2 MYO1E	6.53e-04	190	40	3	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	CADPS2 ERN2 WNK2	6.53e-04	190	40	3	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WNK1 CLMN WNK4	6.53e-04	190	40	3	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK2 STK4 NFKB1	6.53e-04	190	40	3	d83fdc352ebb0c2f2a7c2138bf6e3b7a8ce83a6a
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TENM4 CLMN WNK4	6.63e-04	191	40	3	fe55475ce0666ab5122447a813dc2369e24947b8
Drug	Acetohexamide [968-81-0]; Up 200; 12.4uM; PC3; HT_HG-U133A	KMT2A ITPKC ERN2 TRIO WNK1 DYRK3	1.01e-06	192	40	6	1829_UP
Drug	Cefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; MCF7; HT_HG-U133A	PIP4K2B ITPKC SETD2 ERN2 CLMN MCM3AP	1.17e-06	197	40	6	7186_DN
Drug	Ethotoin [86-35-1]; Down 200; 19.6uM; PC3; HT_HG-U133A	STK4 KMT2A SETD2 NAA15 WNK1	1.89e-05	188	40	5	4545_DN
Drug	Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A	STK4 KMT2A SETD2 NAA15 WNK1	2.04e-05	191	40	5	6020_DN
Drug	Levonordefrin [829-74-3]; Down 200; 21.8uM; PC3; HT_HG-U133A	PIP4K2B ITPKC SETD2 TENM4 DYRK3	2.20e-05	194	40	5	5854_DN
Drug	Tribenoside [10310-32-4]; Down 200; 8.4uM; MCF7; HT_HG-U133A	STK4 PIP4K2B ERN2 AFF4 MCM3AP	2.31e-05	196	40	5	5429_DN
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; PC3; HT_HG-U133A	STK4 KMT2A AKT3 SETD2 TRIO	2.31e-05	196	40	5	6760_DN
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	KMT2A PIP4K2B TRIO MCM3AP POLR3G	2.31e-05	196	40	5	4760_DN
Drug	Streptomycin sulfate [3810-74-0]; Down 200; 2.8uM; PC3; HT_HG-U133A	PIP4K2B SETD2 ERN2 TRIO POLR3G	2.43e-05	198	40	5	5837_DN
Drug	Dapsone [80-08-0]; Down 200; 16.2uM; MCF7; HT_HG-U133A	ITPKC ERN2 TRIO CLMN AFF4	2.49e-05	199	40	5	5498_DN
Drug	estradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	PIP4K2B TENM4 ERN2 DYRK3 POLR3G	2.49e-05	199	40	5	988_UP
Drug	colchicine; Down 200; 0.1uM; MCF7; HG-U133A	KMT2A PIP4K2B NCLN ERN2 WNK1	2.49e-05	199	40	5	644_DN
Drug	wartmannin	DOCK2 AKT3 SETD2 MYO1E PDGFRB RUFY1 NFKB1 RPS6KB1	7.00e-05	811	40	8	CID000005691
Drug	MolPort-016-580-972	AKT3 PDGFRB NFKB1	9.87e-05	51	40	3	CID009938589
Drug	Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A	STK4 KMT2A AFF4 MCM3AP	1.76e-04	160	40	4	4404_UP
Drug	SAHA; Down 200; 10uM; HL60; HT_HG-U133A	TPT1 COLGALT2 JADE1 NFKB1	2.76e-04	180	40	4	2680_DN
Drug	pifithrin-alpha	SETD2 NFKB1 RPS6KB1	2.87e-04	73	40	3	CID000004817
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	KMT2A TENM4 ERN2 DYRK3	2.88e-04	182	40	4	998_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A	STK4 KMT2A CLMN DYRK3	3.13e-04	186	40	4	6671_UP
Drug	torcetrapib	STK4 KMT2A PIP4K2B AKT3 NAA15	3.17e-04	342	40	5	ctd:C483909
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; MCF7; HT_HG-U133A	STK4 ERN2 TRIO WNK1	3.20e-04	187	40	4	3278_DN
Drug	Dicumarol [66-76-2]; Down 200; 11.8uM; PC3; HT_HG-U133A	STK4 KMT2A TRIO WNK1	3.20e-04	187	40	4	4323_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	STK4 KMT2A SETD2 WNK1	3.20e-04	187	40	4	4302_DN
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; PC3; HT_HG-U133A	KMT2A AKT3 TRIO AFF4	3.33e-04	189	40	4	3788_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	STK4 NAA15 WNK1 POLR3G	3.33e-04	189	40	4	1045_DN
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A	STK4 KMT2A COLGALT2 TRIO	3.33e-04	189	40	4	6649_DN
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; PC3; HT_HG-U133A	STK4 KMT2A ERN2 WNK1	3.39e-04	190	40	4	4507_DN
Drug	Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; MCF7; HT_HG-U133A	KMT2A TPT1 TRIO WNK1	3.39e-04	190	40	4	4421_DN
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	STK4 SETD2 TRIO WNK1	3.46e-04	191	40	4	4279_DN
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A	STK4 ERN2 WNK1 AFF4	3.46e-04	191	40	4	4981_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	STK4 KMT2A SETD2 WNK1	3.46e-04	191	40	4	4269_DN
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT_HG-U133A	STK4 KMT2A ERN2 WNK1	3.46e-04	191	40	4	3926_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A	KMT2A NAA15 TRIO WNK1	3.46e-04	191	40	4	6644_DN
Drug	Meclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A	STK4 ERN2 WNK1 DYRK3	3.46e-04	191	40	4	3605_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	STK4 KMT2A MDN1 POLR3G	3.46e-04	191	40	4	1059_DN
Drug	Pronethalol hydrochloride [51-02-5]; Down 200; 15uM; MCF7; HT_HG-U133A	STK4 KMT2A SETD2 WNK1	3.53e-04	192	40	4	4104_DN
Drug	Phenacetin [62-44-2]; Down 200; 22.4uM; HL60; HT_HG-U133A	STK4 ERN2 MCM3AP POLR3G	3.53e-04	192	40	4	2471_DN
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; PC3; HT_HG-U133A	STK4 ERN2 TRIO AFF4	3.53e-04	192	40	4	6664_DN
Drug	Cyanocobalamin [68-19-9]; Down 200; 3uM; MCF7; HT_HG-U133A	STK4 SETD2 ERN2 WNK1	3.53e-04	192	40	4	3252_DN
Drug	N-acetylcysteine	STK4 TXNL1 SETD2 PDGFRB NFKB1 RPS6KB1	3.55e-04	546	40	6	CID000000581
Drug	STOCK1N-35215; Up 200; 10uM; MCF7; HT_HG-U133A	STK4 AKT3 TENM4 DYRK3	3.60e-04	193	40	4	6422_UP
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; HL60; HT_HG-U133A	TPT1 PIP4K2B ERN2 WNK1	3.60e-04	193	40	4	2477_DN
Drug	Bromperidol [10457-90-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A	ITPKC AKT3 TRIO PDGFRB	3.60e-04	193	40	4	2872_UP
Drug	Prednicarbate [73771-04-7]; Down 200; 8.2uM; PC3; HT_HG-U133A	KMT2A AKT3 TENM4 TRIO	3.60e-04	193	40	4	5119_DN
Drug	Methylatropine nitrate [52-88-0]; Down 200; 11uM; HL60; HT_HG-U133A	ERN2 MCM3AP DYRK3 POLR3G	3.60e-04	193	40	4	3116_DN
Drug	AC1OAGKW	PIP4K2B AKT3 PDGFRB RPS6KB1	3.60e-04	193	40	4	CID006857413
Drug	Simvastatin [79902-63-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	MYO1E WNK1 PDGFRB MCM3AP	3.67e-04	194	40	4	4828_UP
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	STK4 KMT2A NAA15 ERN2	3.67e-04	194	40	4	4361_DN
Drug	CP-645525-01 [287190-82-3]; Up 200; 10uM; MCF7; HT_HG-U133A	AFF4 CDH18 MCM3AP DYRK3	3.67e-04	194	40	4	7522_UP
Drug	F0447-0125; Up 200; 10uM; MCF7; HT_HG-U133A	PIP4K2B PDGFRB MCM3AP DYRK3	3.67e-04	194	40	4	6424_UP
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	STK4 KMT2A SETD2 WNK1	3.67e-04	194	40	4	4727_DN
Drug	Demeclocycline hydrochloride [64-73-3]; Down 200; 8uM; MCF7; HT_HG-U133A	SETD2 ERN2 WNK1 DYRK3	3.67e-04	194	40	4	3604_DN
Drug	0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A	STK4 KMT2A CDH18 MCM3AP	3.67e-04	194	40	4	3855_UP
Drug	5186324; Up 200; 2uM; MCF7; HT_HG-U133A_EA	PIP4K2B TENM4 TRIO WNK1	3.75e-04	195	40	4	900_UP
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A	ITPKC SETD2 AFF4 DYRK3	3.75e-04	195	40	4	4706_DN
Drug	Chlorambucil [305-03-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A	KMT2A TPT1 PIP4K2B CDH18	3.75e-04	195	40	4	4345_DN
Drug	5279552; Down 200; 22uM; MCF7; HT_HG-U133A_EA	STK4 KMT2A TRIO POLR3G	3.75e-04	195	40	4	843_DN
Drug	Letrozole [112809-51-5]; Down 200; 14uM; HL60; HT_HG-U133A	STK4 ITPKC ERN2 WNK1	3.75e-04	195	40	4	2916_DN
Drug	GSK-3 Inhibitor IX; Up 200; 0.5uM; PC3; HT_HG-U133A	STK4 ITPKC COLGALT2 ERN2	3.75e-04	195	40	4	7106_UP
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; MCF7; HT_HG-U133A	SETD2 TRIO WNK1 MCM3AP	3.75e-04	195	40	4	3835_DN
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; PC3; HT_HG-U133A	PIP4K2B ERN2 TRIO AFF4	3.75e-04	195	40	4	3714_DN
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	ERN2 TRIO RUFY1 MCM3AP	3.75e-04	195	40	4	3864_DN
Drug	Hecogenin [467-55-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	STK4 AKT3 TRIO AFF4	3.75e-04	195	40	4	7175_UP
Drug	Sulfapyridine [144-83-2]; Down 200; 16uM; MCF7; HT_HG-U133A	STK4 ERN2 WNK1 MCM3AP	3.75e-04	195	40	4	6799_DN
Drug	Cefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; HL60; HT_HG-U133A	KMT2A SETD2 WNK1 DYRK3	3.75e-04	195	40	4	6159_DN
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	STK4 PIP4K2B AFF4 POLR3G	3.75e-04	195	40	4	2649_DN
Drug	monastrol; Down 200; 100uM; MCF7; HG-U133A	KMT2A TPT1 ERN2 TRIO	3.82e-04	196	40	4	627_DN
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A	KMT2A PIP4K2B SETD2 TRIO	3.82e-04	196	40	4	1666_UP
Drug	PNU-0230031 [267429-39-0]; Up 200; 1uM; PC3; HT_HG-U133A	STK4 KMT2A ERN2 WNK1	3.82e-04	196	40	4	4291_UP
Drug	Mesoridazine besylate [32672-69-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	JADE1 MYO1E TRIO POLR3G	3.82e-04	196	40	4	7017_DN
Drug	pentamidine isethionate salt; Up 200; 100uM; MCF7; HG-U133A	KMT2A TPT1 COLGALT2 WNK1	3.82e-04	196	40	4	639_UP
Drug	Mephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; PC3; HT_HG-U133A	STK4 ERN2 TRIO WNK1	3.82e-04	196	40	4	3685_DN
Drug	Meclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; HL60; HG-U133A	KMT2A TPT1 SETD2 MCM3AP	3.82e-04	196	40	4	1445_DN
Drug	Cholecalciferol [67-97-0]; Down 200; 10.4uM; MCF7; HT_HG-U133A	PIP4K2B MYO1E ERN2 POLR3G	3.82e-04	196	40	4	3298_DN
Drug	Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	KMT2A PIP4K2B TRIO WNK1	3.89e-04	197	40	4	3748_DN
Drug	NS-398; Down 200; 10uM; MCF7; HT_HG-U133A	STK4 TRIO WNK1 NFKB1	3.89e-04	197	40	4	6911_DN
Drug	Dimenhydrinate [523-87-5]; Down 200; 8.6uM; MCF7; HT_HG-U133A	KMT2A MYO1E CLMN POLR3G	3.89e-04	197	40	4	7431_DN
Drug	Trimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A	STK4 AKT3 SETD2 ERN2	3.89e-04	197	40	4	4787_DN
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	STK4 KMT2A SETD2 WNK1	3.89e-04	197	40	4	1314_DN
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	KMT2A TRIO MCM3AP POLR3G	3.89e-04	197	40	4	3865_DN
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	KMT2A PIP4K2B AFF4 DYRK3	3.89e-04	197	40	4	6105_DN
Drug	Vitamin K2 [11032-49-8]; Down 200; 9uM; PC3; HT_HG-U133A	KMT2A TENM4 ERN2 TRIO	3.89e-04	197	40	4	3798_DN
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; PC3; HT_HG-U133A	STK4 KMT2A AKT3 AFF4	3.89e-04	197	40	4	6688_UP
Drug	5194442; Down 200; 20uM; MCF7; HT_HG-U133A	ERN2 WNK1 PDGFRB DYRK3	3.97e-04	198	40	4	6599_DN
Drug	Propafenone hydrochloride [34183-22-7]; Down 200; 10.6uM; HL60; HG-U133A	TPT1 AKT3 SETD2 MCM3AP	3.97e-04	198	40	4	1722_DN
Drug	Spectinomycin dihydrochloride [21736-83-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A	STK4 KMT2A SETD2 TRIO	3.97e-04	198	40	4	4773_DN
Drug	Sulfamethoxazole [723-46-6]; Down 200; 15.8uM; PC3; HT_HG-U133A	STK4 PIP4K2B ERN2 TRIO	3.97e-04	198	40	4	7366_DN
Drug	Phenacetin [62-44-2]; Down 200; 22.4uM; MCF7; HT_HG-U133A	STK4 PIP4K2B NCLN DYRK3	3.97e-04	198	40	4	2832_DN
Drug	Dyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; HL60; HT_HG-U133A	KMT2A ERN2 DYRK3 POLR3G	3.97e-04	198	40	4	2392_DN
Drug	paclitaxel; Up 200; 0.1uM; MCF7; HG-U133A	KMT2A COLGALT2 WNK1 CLMN	3.97e-04	198	40	4	640_UP
Drug	Betazole hydrochloride; Down 200; 27uM; MCF7; HT_HG-U133A	ITPKC SETD2 ERN2 WNK1	3.97e-04	198	40	4	5445_DN
Drug	(R)-Propranolol hydrochloride [13071-11-9]; Down 200; 13.6uM; MCF7; HT_HG-U133A	ERN2 TRIO DYRK3 POLR3G	3.97e-04	198	40	4	3553_DN
Drug	cyclosporine A; Down 200; 1uM; MCF7; HG-U133A	KMT2A ERN2 TRIO WNK1	3.97e-04	198	40	4	602_DN
Drug	AC1OAGKB	AKT3 PDGFRB NFKB1 RPS6KB1	3.97e-04	198	40	4	CID006857406
Drug	Sulfacetamide sodic hydrate [6209-17-2]; Up 200; 15.8uM; PC3; HT_HG-U133A	CADPS2 ERN2 WNK1 AFF4	4.05e-04	199	40	4	6349_UP
Drug	nifedipine; Down 200; 10uM; MCF7; HG-U133A	KMT2A TENM4 ERN2 TRIO	4.05e-04	199	40	4	603_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; HL60; HG-U133A	STK4 KMT2A TPT1 MCM3AP	4.05e-04	199	40	4	2032_DN
Drug	Mianserine hydrochloride [21535-47-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	STK4 PIP4K2B TRIO DYRK3	4.05e-04	199	40	4	2231_DN
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; MCF7; HT_HG-U133A	PIP4K2B TRIO WNK1 DYRK3	4.05e-04	199	40	4	2806_DN
Drug	2-propylpentanoic acid; Down 200; 1000uM; HL60; HT_HG-U133A	STK4 ITPKC WNK1 POLR3G	4.05e-04	199	40	4	6168_DN
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK1 WNK4 WNK2	4.60e-08	6	40	3	DOID:4479 (implicated_via_orthology)
Disease	Pseudohypoaldosteronism type 2A	WNK1 WNK4	1.07e-05	4	40	2	cv:C1840389
Disease	Pseudohypoaldosteronism, type 2	WNK1 WNK4	1.07e-05	4	40	2	cv:C1449844
Disease	pseudohypoaldosteronism (is_implicated_in)	WNK1 WNK4	4.99e-05	8	40	2	DOID:4479 (is_implicated_in)
Disease	transient cerebral ischemia (biomarker_via_orthology)	WNK1 WNK4 WNK2 NFKB1	6.07e-05	157	40	4	DOID:224 (biomarker_via_orthology)
Disease	Pseudohypoaldosteronism	WNK1 WNK4	8.01e-05	10	40	2	C0033805
Disease	pancreatic adenocarcinoma (is_marker_for)	AKT3 NFKB1	8.01e-05	10	40	2	DOID:4074 (is_marker_for)
Disease	Hyperpotassemia and Hypertension, Familial	WNK1 WNK4	8.01e-05	10	40	2	C2713447
Disease	Pseudohypoaldosteronism, Type I	WNK1 WNK4	8.01e-05	10	40	2	C0268436
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	WNK1 WNK4	8.01e-05	10	40	2	C1449843
Disease	Pseudohypoaldosteronism, Type II	WNK1 WNK4	8.01e-05	10	40	2	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	WNK1 WNK4	8.01e-05	10	40	2	C1449842
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SETD2 TRIO	2.41e-04	17	40	2	DOID:0060307 (is_implicated_in)
Disease	Myeloid Leukemia	KMT2A AGO2	2.70e-04	18	40	2	C0023470
Disease	Leukemia, Monocytic, Chronic	KMT2A AGO2	2.70e-04	18	40	2	C0023466
Disease	Neurodevelopmental Disorders	KMT2A SETD2 TRIO	2.75e-04	93	40	3	C1535926
Disease	type 2 diabetes mellitus (implicated_via_orthology)	AKT3 AFF4 RPS6KB1	3.93e-04	105	40	3	DOID:9352 (implicated_via_orthology)
Disease	monocyte percentage of leukocytes	SETD2 WNK1 PDGFRB RUFY1 NFKB1 MCM3AP	4.24e-04	731	40	6	EFO_0007989
Disease	glioblastoma (is_implicated_in)	AKT3 PDGFRB	4.85e-04	24	40	2	DOID:3068 (is_implicated_in)
Disease	Schizophrenia	KMT2A TPT1 TENM4 CMYA5 CADPS2 PDGFRB	1.14e-03	883	40	6	C0036341
Disease	autism spectrum disorder (implicated_via_orthology)	NAA15 CADPS2 PDGFRB	1.15e-03	152	40	3	DOID:0060041 (implicated_via_orthology)
Disease	S100 calcium-binding protein B measurement	KMT2A MCM3AP	1.22e-03	38	40	2	EFO_0600012
Disease	3-hydroxypropylmercapturic acid measurement	KMT2A CADPS2 ERN2 WNK1	1.30e-03	352	40	4	EFO_0007014

Protein segments in the cluster

Peptide	Gene	Start	Entry
PKDMMPRILEDEGFY	CC2D2B	186	Q6DHV5
DPYVREFGIMVKDEM	AGO2	391	Q9UKV8
ITPPEKYDEDGMDCM	AKT3	446	Q9Y243
YVRPMDGQESMEPKL	AFF4	256	Q9UHB7
PRKDMYEKMVAVDPG	ITPKC	506	Q96DU7
EPEMLAMETAVPVYF	NCLN	131	Q969V3
KGPGEMPEIRSYMEE	MDN1	5546	Q9NU22
LGEMPAEPMTIDELY	NAXE	166	Q8NCW5
DDPVIEGPMYVTEMA	ERN2	66	Q76MJ5
EGPMYVTEMAFLSDP	ERN2	71	Q76MJ5
PPKMKSEDMAEEDVY	MCM3AP	1461	O60318
MVYECIPLPKEVGDM	CWF19L2	766	Q2TBE0
VETEMGLKPIEMFYL	MYRFL	281	Q96LU7
PVEYPMETSGIEQMD	RPS6KB1	471	P23443
LAFMPPGYEEDMKIT	NAA15	836	Q9BXJ9
DMMQAPGPSKEEIIY	RESP18	196	Q5W5W9
MKVEKEYGVREMPDF	DOCK2	1611	Q92608
SEMKYSVLPDMVDEP	CMYA5	1236	Q8N3K9
DVPKPGMDLADTYIM	CADPS2	1166	Q86UW7
DGPYIVTVPEMSDMG	CDH18	161	Q13634
KPEFMDEVLTPEYMG	KMT2A	2461	Q03164
FGKMLPVDEFLPVMY	COLGALT2	516	Q8IYK4
VYDTFMMIDETKCPP	DYRK3	31	O43781
DESVDYVPMLDMKGD	PDGFRB	746	P09619
YSKMDGPEVMIEQPI	SYDE2	1126	Q5VT97
EFYEPEALMMEEEGM	RUFY1	236	Q96T51
PVPVMLMPDDFKAYS	PIP4K2B	61	P78356
EEFKEMGMPELDEYT	JADE1	156	Q6IE81
KNEEMDLEEPEGYMP	CLMN	751	Q96JQ2
VTPYMIFFKDGLEME	TPT1	156	P13693
KPDMDAMEPSYELIH	TENM4	2491	Q6N022
ETMKRMPYFIETPEE	POLR3G	66	O15318
EMDLGTPTYDENPMK	SETD2	2436	Q9BYW2
EMAEGKPPYADIHPM	STK4	216	Q13043
KSVIGTPEFMAPEMY	WNK1	381	Q9H4A3
SVIGTPEFMAPEMYE	WNK2	356	Q9Y3S1
VIGTPEFMAPEMYEE	WNK4	336	Q96J92
VVEGYMALMKEDGVP	TRIO	1991	O75962
DTDIPKGYMDLMPFI	TXNL1	116	O43396
PFKQMPYFGEKEIEM	MYO1E	61	Q12965
MAEDDPYLGRPEQMF	NFKB1	1	P19838