Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ESR1 ZKSCAN2 ZBTB41 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	9.96e-09	1412	97	25	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ESR1 ZKSCAN2 ZBTB41 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	1.91e-08	1459	97	25	GO:0000977
GeneOntologyMolecularFunction	chromatin insulator sequence binding	ZFY CTCFL CTCF	3.83e-06	7	97	3	GO:0043035
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF132 ZNF311 ZNF536 ZNF138 ESR1 ZKSCAN2 ZBTB41 ZFY ZNF836 CTCFL ZNF732 CTCF ZNF718 RBAK ZNF611 ZNF528 ZNF81 ZNF99 SP7	7.20e-06	1244	97	19	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF132 ZNF311 ZNF536 ZNF138 ESR1 ZKSCAN2 ZBTB41 ZFY ZNF836 CTCFL ZNF732 CTCF ZNF718 RBAK ZNF611 ZNF528 ZNF81 ZNF99 SP7	9.78e-06	1271	97	19	GO:0000987
GeneOntologyMolecularFunction	cytoskeletal protein binding	EPS8 MYH2 ANK2 OFD1 RTCB OBSCN TOGARAM1 NEB AFAP1 NF1 XIRP2 FMN1 PHACTR3 FMN2 GOLGA8B MTCL1 KIF13A	2.00e-05	1099	97	17	GO:0008092
GeneOntologyMolecularFunction	microtubule binding	TOGARAM1 NF1 FMN1 FMN2 GOLGA8B MTCL1 KIF13A	7.62e-04	308	97	7	GO:0008017
GeneOntologyMolecularFunction	tubulin binding	OFD1 TOGARAM1 NF1 FMN1 FMN2 GOLGA8B MTCL1 KIF13A	1.14e-03	428	97	8	GO:0015631
GeneOntologyBiologicalProcess	protein localization to M-band	ANK2 OBSCN	2.05e-05	2	94	2	GO:0036309
Domain	-	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	1.29e-16	679	100	27	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	2.22e-16	694	100	27	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	3.37e-15	775	100	27	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	3.59e-15	777	100	27	PS00028
Domain	Znf_C2H2-like	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	6.46e-15	796	100	27	IPR015880
Domain	Znf_C2H2	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	8.50e-15	805	100	27	IPR007087
Domain	ZnF_C2H2	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK AEBP2 ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	9.30e-15	808	100	27	SM00355
Domain	zf-C2H2	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 DZIP1 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	1.98e-14	693	100	25	PF00096
Domain	KRAB	ZNF132 ZNF133 ZNF311 ZKSCAN2 ZNF248 ZNF19 ZNF836 ZNF878 ZNF732 ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99	6.84e-12	358	100	17	PS50805
Domain	KRAB	ZNF132 ZNF133 ZNF311 ZKSCAN2 ZNF248 ZNF19 ZNF836 ZNF878 ZNF732 ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99	6.84e-12	358	100	17	PF01352
Domain	KRAB	ZNF132 ZNF133 ZNF311 ZKSCAN2 ZNF248 ZNF19 ZNF836 ZNF878 ZNF732 ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99	1.10e-11	369	100	17	SM00349
Domain	KRAB	ZNF132 ZNF133 ZNF311 ZKSCAN2 ZNF248 ZNF19 ZNF836 ZNF878 ZNF732 ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99	1.15e-11	370	100	17	IPR001909
Domain	GOLGA6L	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA6L9	1.15e-08	6	100	4	IPR026737
Domain	GOLGA2L5	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA8B GOLGA6L9	3.22e-08	18	100	5	PF15070
Domain	Golgin_A	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA8B GOLGA6L9	3.22e-08	18	100	5	IPR024858
Domain	zf-C2H2_6	ZNF133 ZNF311 ZBTB41 ZNF836 ZNF878 ZNF732 ZNF718 ZNF611 ZNF700 ZNF99	7.11e-06	314	100	10	PF13912
Domain	MIF4G	CTIF UPF2	1.24e-03	10	100	2	SM00543
Domain	MIF4G	CTIF UPF2	1.24e-03	10	100	2	PF02854
Domain	MIF4G-like_typ-3	CTIF UPF2	1.24e-03	10	100	2	IPR003890
Domain	MIF4-like	CTIF UPF2	2.85e-03	15	100	2	IPR016021
Domain	FH2	FMN1 FMN2	2.85e-03	15	100	2	PS51444
Domain	-	CTIF UPF2	2.85e-03	15	100	2	1.25.40.180
Domain	FH2_Formin	FMN1 FMN2	2.85e-03	15	100	2	IPR015425
Domain	FH2	FMN1 FMN2	2.85e-03	15	100	2	PF02181
Domain	FH2	FMN1 FMN2	2.85e-03	15	100	2	SM00498
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF132 ZNF133 ZNF138 ZNF19	1.55e-07	17	101	4	7557990
Pubmed	The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development.	EP400 ALDH18A1 SP7	6.66e-06	13	101	3	37024457
Pubmed	Obscurin regulates the organization of myosin into A bands.	MYH2 OBSCN	8.35e-06	2	101	2	15013951
Pubmed	A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation.	ESR1 CTCF	8.35e-06	2	101	2	31372638
Pubmed	Differential DNA methylation and CTCF binding between the ESR1 promoter a of MCF-7 and MDA-MB-231 breast cancer cells.	ESR1 CTCF	8.35e-06	2	101	2	38236307
Pubmed	CTCF and CTCFL in cancer.	CTCFL CTCF	8.35e-06	2	101	2	32334335
Pubmed	Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.	CTCFL CTCF	8.35e-06	2	101	2	32393311
Pubmed	The ability to induce microtubule acetylation is a general feature of formin proteins.	FMN1 FMN2	8.35e-06	2	101	2	23110170
Pubmed	Discovering a binary CTCF code with a little help from BORIS.	CTCFL CTCF	8.35e-06	2	101	2	29077515
Pubmed	BORIS and CTCF are overexpressed in squamous intraepithelial lesions and cervical cancer.	CTCFL CTCF	8.35e-06	2	101	2	26125810
Pubmed	The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells.	CTCFL CTCF	8.35e-06	2	101	2	23553099
Pubmed	Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer.	ESR1 NF1	8.35e-06	2	101	2	32142667
Pubmed	Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells.	CTCFL CTCF	8.35e-06	2	101	2	28145452
Pubmed	The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer.	CTCFL CTCF	8.35e-06	2	101	2	12191639
Pubmed	The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.	CTCFL CTCF	8.35e-06	2	101	2	22709888
Pubmed	The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis.	CTCFL CTCF	8.35e-06	2	101	2	34158481
Pubmed	BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.	CTCFL CTCF	8.35e-06	2	101	2	12011441
Pubmed	Analysis of the DNA sequence and duplication history of human chromosome 15.	GOLGA6L4 GOLGA6L10 GOLGA6L19 GOLGA8B	2.19e-05	56	101	4	16572171
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	URI1 ZC3H13 ESR1 ZBTB41 DZIP1 ZNF836 CTCF ZNF718 RBAK AEBP2 ZNF99	2.37e-05	808	101	11	20412781
Pubmed	Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma.	CTCFL CTCF	2.50e-05	3	101	2	22544282
Pubmed	Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line.	ANK2 OBSCN	2.50e-05	3	101	2	18782775
Pubmed	BORIS Expression in Ovarian Cancer Precursor Cells Alters the CTCF Cistrome and Enhances Invasiveness through GALNT14.	CTCFL CTCF	2.50e-05	3	101	2	31292201
Pubmed	Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.	CTCFL CTCF	2.50e-05	3	101	2	16140944
Pubmed	Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.	ANK2 OBSCN	2.50e-05	3	101	2	12527750
Pubmed	Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer.	CTCFL CTCF	2.50e-05	3	101	2	25499215
Pubmed	CTCF and BORIS regulate Rb2/p130 gene transcription: a novel mechanism and a new paradigm for understanding the biology of lung cancer.	CTCFL CTCF	2.50e-05	3	101	2	21325284
Pubmed	Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress.	CTCFL CTCF	2.50e-05	3	101	2	33411704
Pubmed	Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.	CTCFL CTCF	2.50e-05	3	101	2	21296871
Pubmed	Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins.	FMN1 FMN2	4.99e-05	4	101	2	19605360
Pubmed	IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency.	IFI16 ZNF589	4.99e-05	4	101	2	35969079
Pubmed	Methylation of bone SOST impairs SP7, RUNX2, and ERα transactivation in patients with postmenopausal osteoporosis.	ESR1 SP7	4.99e-05	4	101	2	30257098
Pubmed	Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling.	NEB XIRP2	4.99e-05	4	101	2	23985323
Pubmed	SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.	ESR1 SAFB2	4.99e-05	4	101	2	12660241
Pubmed	CTCF prevents genomic instability by promoting homologous recombination-directed DNA double-strand break repair.	CTCF MDC1	4.99e-05	4	101	2	28973861
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	RPL21 EPS8 ZFY CCM2 NF1 FMN1 FMN2 DHX29	7.61e-05	475	101	8	31040226
Pubmed	Antagonistic interactions between osterix and pyrophosphate during cementum formation.	ANKH SP7	8.30e-05	5	101	2	31059863
Pubmed	DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.	CTCFL CTCF	8.30e-05	5	101	2	18413740
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ANK2 OBSCN RIOK3 DZIP1 NEB CCDC141 UPF2 XIRP2	1.04e-04	497	101	8	23414517
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	ABHD10 WAC ALDH18A1	1.22e-04	33	101	3	25582440
Pubmed	Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.	ANK2 EP400	1.24e-04	6	101	2	31142747
Pubmed	Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.	URI1 ESR1	1.24e-04	6	101	2	25453901
Pubmed	Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.	MYH2 NF1	1.24e-04	6	101	2	8808709
Pubmed	Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus.	ESR1 TLR3	1.24e-04	6	101	2	22659029
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RPL21 EP400 RTCB RIOK3 IFI16 NCAPG2 ORC1 NF1 UPF2 MDC1 SAFB2 ALDH18A1 DHX29	1.50e-04	1353	101	13	29467282
Pubmed	Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.	ESR1 FMN2	1.74e-04	7	101	2	23437003
Pubmed	Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.	ZKSCAN2 IFI16 CTCFL	1.86e-04	38	101	3	28218735
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF311 ZNF878 ZNF718 ZNF589 ZNF611	1.91e-04	181	101	5	37372979
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EMC1 OFD1 RTCB BRCC3 DZIP1 NHSL1 NF1 FMN2 MTCL1 KIF13A	2.07e-04	861	101	10	36931259
Pubmed	Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.	ESR1 IFI16	2.31e-04	8	101	2	24413532
Pubmed	CTCF regulates the local epigenetic state of ribosomal DNA repeats.	CTCFL CTCF	2.31e-04	8	101	2	21059229
Pubmed	Chromosome localization of two new mammalian kinases related to yeast and fly chromosome segregation-regulators.	MYH2 NF1	2.31e-04	8	101	2	9434955
Pubmed	Cloning and expression analysis of murine phospholipase D1.	MYH2 NF1	2.31e-04	8	101	2	9307024
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	ZNF133 URI1 ANK2 ZC3H13 UPF2	2.45e-04	191	101	5	20195357
Pubmed	Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.	ESR1 FMN1 SP7	2.89e-04	44	101	3	20200978
Pubmed	A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization.	ANKH SP7	2.97e-04	9	101	2	21788370
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ZC3H13 OBSCN ZBTB41 REV3L TLR3 FMN2 ALDH18A1 MTCL1 SP7	3.00e-04	736	101	9	29676528
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	APOBEC3D ZC3H13 LSM12 ALDH18A1 DHX29	3.24e-04	203	101	5	35012549
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF133 FOXRED1 ANK2 NUCB1 BRCC3 DZIP1 REV3L WAC ZNF836 FMN2 LRPAP1 ZNF528	3.54e-04	1285	101	12	35914814
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF311 ZNF138 NCAPG2 ZNF836 ZNF718 OSBPL11 ALDH18A1	3.55e-04	451	101	7	36168627
Pubmed	The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation.	CTCFL CTCF	3.70e-04	10	101	2	17048991
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EPS8 EMC1 EP400 RTCB ESR1 LSM12 ORC1 ZNF800 AFAP1 CTCF MDC1 ALDH18A1 DHX29	3.98e-04	1497	101	13	31527615
Pubmed	A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.	ANK2 UPF2 KIF13A	4.74e-04	52	101	3	22219177
Pubmed	ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae.	NF1 SP7	5.41e-04	12	101	2	17141628
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ZC3H13 IFI16 WAC OSBPL11 MTCL1 KIF13A DHX29	6.78e-04	503	101	7	16964243
Pubmed	New sequence variants associated with bone mineral density.	ESR1 SP7	7.43e-04	14	101	2	19079262
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	FMN1 FMN2	7.43e-04	14	101	2	26272686
Pubmed	Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation.	ESR1 NCAPG2	7.43e-04	14	101	2	26166704
Pubmed	Transcriptional map of chromosome region 6q16-->q21.	ESR1 REV3L	7.43e-04	14	101	2	10575223
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RPL21 RTCB ZC3H13 IFI16 ZFY CTCF MDC1 SAFB2 ALDH18A1	8.20e-04	847	101	9	35850772
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RPL21 URI1 NUCB1 ZFY ZNF800 CTCF MDC1	9.50e-04	533	101	7	30554943
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	RPL21 OBSCN BRCC3 AFAP1	9.57e-04	149	101	4	25184681
Pubmed	Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.	URI1 OFD1 OSBPL11	1.08e-03	69	101	3	34941261
Pubmed	DNA sequence and analysis of human chromosome 18.	RIOK3 MTCL1	1.10e-03	17	101	2	16177791
Pubmed	SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.	ANKH SP7	1.10e-03	17	101	2	22318228
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	ANK2 TLR3	1.24e-03	18	101	2	31910261
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	ANKRD13B NUCB1	1.24e-03	18	101	2	29229865
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL21 EP400 RTCB ZC3H13 BRCC3 IFI16 WAC ORC1 CTCF MDC1 SAFB2	1.35e-03	1294	101	11	30804502
Pubmed	Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.	CTCFL MDC1	1.38e-03	19	101	2	14578343
Pubmed	Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.	OBSCN NEB	1.38e-03	19	101	2	27171814
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	EP400 IFI16 WAC MDC1 SAFB2	1.44e-03	283	101	5	30585729
Pubmed	The molecular complex of ciliary and golgin protein is crucial for skull development.	GOLGA8B SP7	1.53e-03	20	101	2	34128978
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RPL21 ANK2 EP400 RTCB WAC CTCF SAFB2 OSBPL11 DHX29	1.61e-03	934	101	9	33916271
Pubmed	Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development.	GOLGA8B SP7	1.69e-03	21	101	2	27118846
Pubmed	Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.	NF1 ALDH18A1	1.69e-03	21	101	2	25340873
Pubmed	PEG3 binds to H19-ICR as a transcriptional repressor.	PRPF18 CTCF	1.86e-03	22	101	2	27824289
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EP400 ZC3H13 IFI16 NF1 MDC1 SAFB2 OSBPL11 DHX29	1.91e-03	774	101	8	15302935
Pubmed	Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.	ZBTB41 PRPF18	2.03e-03	23	101	2	24925725
Pubmed	CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.	EP400 AEBP2	2.03e-03	23	101	2	31281901
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	APOBEC3D ESR1	2.03e-03	23	101	2	34473953
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	FOXRED1 ABHD10 GSS OSBPL11	2.04e-03	183	101	4	31932471
Pubmed	Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.	ANKH SP7	2.21e-03	24	101	2	29174564
Pubmed	Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion.	GOLGA8B SP7	2.21e-03	24	101	2	38814743
Pubmed	Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse.	OFD1 DZIP1	2.40e-03	25	101	2	29487109
Pubmed	Decidualisation and placentation defects are a major cause of age-related reproductive decline.	ESR1 ERVW-1	2.40e-03	25	101	2	28874785
Pubmed	Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis.	GOLGA8B SP7	2.40e-03	25	101	2	27471260
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	RPL21 RTCB OBSCN FNDC11 ALDH18A1 MTCL1	2.48e-03	468	101	6	36042349
Pubmed	Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis.	CTCF SP7	2.59e-03	26	101	2	26244796
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ZNF536 ESR1 IFI16 DENND3 DDIAS CTCFL AEBP2 CC2D2A	2.60e-03	814	101	8	23251661
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MYH2 ZNF536 REV3L NEB NF1 PHACTR3 MTCL1	2.63e-03	638	101	7	31182584
Pubmed	Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.	ESR1 SP7	2.80e-03	27	101	2	19801982
Interaction	TRIM28 interactions	RPL21 ZNF133 ZNF311 URI1 EMC1 RTCB ESR1 BRCC3 CTIF IFI16 NCAPG2 ZNF248 LSM12 ZNF19 ZNF878 UPF2 ZNF732 ZNF718 MDC1 ZNF589 RBAK ZNF611 ZNF81 DHX29	7.03e-08	1474	96	24	int:TRIM28
Interaction	OBSCN interactions	RPL21 MYH2 ANK2 OBSCN IFI16	2.09e-05	70	96	5	int:OBSCN
Interaction	ZNF652 interactions	ESR1 CTCFL CTCF RBAK	2.26e-05	35	96	4	int:ZNF652
Cytoband	15q25.2	GOLGA6L4 GOLGA6L10 GOLGA6L9	1.16e-04	43	100	3	15q25.2
Cytoband	19q12	ZNF536 URI1	8.70e-04	20	100	2	19q12
Cytoband	4p16.3	ZNF732 ZNF718 LRPAP1	8.70e-04	85	100	3	4p16.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	AFAP1 ZNF732 ZNF718 LRPAP1	1.45e-03	222	100	4	chr4p16
Cytoband	Ensembl 112 genes in cytogenetic band chr19q12	ZNF536 URI1	1.96e-03	30	100	2	chr19q12
Cytoband	12p12.3	EPS8 AEBP2	2.23e-03	32	100	2	12p12.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF132 ZNF133 ZNF311 ZNF536 ZNF138 ZKSCAN2 ZBTB41 ZFY ZNF248 ZNF19 ZNF836 CTCFL ZNF800 ZNF878 ZNF732 CTCF ZNF718 ZNF589 RBAK ZNF611 ZNF528 ZNF81 ZNF700 ZNF99 SP7	2.30e-19	718	62	25	28
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABHD10 ANKH ZFY WAC FMN1 OSBPL11	4.49e-06	190	100	6	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZNF536 NCAPG2 ORC1 DDIAS ZNF732 MTCL1	4.92e-06	193	100	6	bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate\|6m / Sample Type, Dataset, Time_group, and Cell type.	ZC3H13 RIOK3 NEB SYTL3 AEBP2 GOLGA8B	6.03e-06	200	100	6	7c261e39ac30b318511373ab7302aa53b8b81b9c
Disease	descending aortic diameter	TRPC3 CTIF CCDC141 AFAP1	1.76e-04	88	93	4	EFO_0021788
Disease	Joubert syndrome (implicated_via_orthology)	TOGARAM1 CC2D2A	2.04e-04	7	93	2	DOID:0050777 (implicated_via_orthology)
Disease	breast carcinoma (is_marker_for)	ESR1 CTCF MDC1	1.20e-03	66	93	3	DOID:3459 (is_marker_for)
Disease	Moyamoya Disease	BRCC3 NF1	1.30e-03	17	93	2	C0026654
Disease	Familial aplasia of the vermis	OFD1 CC2D2A	1.80e-03	20	93	2	cv:C0431399
Disease	physical activity	ESR1 CTCFL AEBP2	2.74e-03	88	93	3	EFO_0003940
Disease	Dwarfism	FBXL3 ORC1	2.81e-03	25	93	2	C0013336
Disease	Cerebral Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0750935
Disease	Intracranial Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0750936
Disease	Pilocytic Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0334583
Disease	Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0280783
Disease	Diffuse Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0280785
Disease	Grade I Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0205768
Disease	Mixed oligoastrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0547065
Disease	Childhood Cerebral Astrocytoma	ESR1 NF1	2.81e-03	25	93	2	C0338070
Disease	Gemistocytic astrocytoma	ESR1 NF1	3.04e-03	26	93	2	C0334581
Disease	Protoplasmic astrocytoma	ESR1 NF1	3.04e-03	26	93	2	C0334580
Disease	Fibrillary Astrocytoma	ESR1 NF1	3.04e-03	26	93	2	C0334582

Protein segments in the cluster

Peptide	Gene	Start	Entry
DEKIRQARSHVHKTT	CCDC185	511	Q8N715
VHKTTRDKVQHLREL	CCDC185	521	Q8N715
AAKKLVRTVVRHHEE	EP400	836	Q96L91
HSVVFHSTVIAKRKE	AEBP2	426	Q6ZN18
EVTKHHSAVFRKRGV	APOBEC3D	236	Q96AK3
RKRTLHETKIRTHST	CAPS2	271	Q9BXY5
SVEASKLKRHVRSHT	CTCFL	351	Q8NI51
VEVSKLKRHIRSHTG	CTCF	361	P49711
HEVEIAHTKKLFRRR	CTIF	176	O43310
FHKDRTDLKTHIVSI	AFAP1	376	Q8N556
KAHEKVTERRPLHTV	CCM2	31	Q9BSQ5
VLHSRHTELKEKLRS	LRPAP1	216	P30533
KHRDSIVETLKRHRV	DHX29	576	Q7Z478
VEKRASRKSSHLHVT	DENND3	451	A2RUS2
VVAHILRKAVEEARH	ATG4C	236	Q96DT6
SLHRKVEIITRASKD	FMN1	1156	Q68DA7
VSVRLHHELKTVEEK	MTCL1	431	Q9Y4B5
VLREKSTLERIHKHQ	OFD1	261	O75665
HGHTVVKKVTRKIIR	ANK2	3891	Q01484
RTRTEHLSEQHKGKV	ANKRD13B	286	Q86YJ7
HVRKIVEKHFRDVES	LSM12	161	Q3MHD2
LKDHTKIRALVRAHS	MDC1	471	Q14676
IKVDTVAAEHLTRKR	EPHB4	136	P54760
SHERNRHVKDKVVQT	IHO1	341	Q8IYA8
KTEVVHKHSRLAEVL	KCNH5	171	Q8NCM2
RIKSRDHLISRHAVK	NHSL1	451	Q5SYE7
EKDHIHRVLDKITDT	ESR1	471	P03372
LRVKSREVHTKVISE	MYH2	1926	Q9UKX2
KKTIRISPHRESDHS	DDIAS	556	Q8IXT1
VRTSKEEKKHEIHLV	GOLGA6L3	116	A6NEY3
VRTSKEEKKHEIHLV	GOLGA6L4	116	A6NEF3
VRTSKEEKKHEIHLV	GOLGA6L9	116	A6NEM1
VRTSKEEKKHEIHLV	GOLGA6L10	116	A6NI86
VRTSKEEKKHEIHLV	GOLGA6L19	116	H0YKK7
FVSHHVRTKLDELKR	NUCB1	91	Q02818
FAHRSELKHAKRIVV	ALDH18A1	61	P54886
ERVKASVEHISRILK	OBSCN	7416	Q5VST9
EHVAKRIESRHSASK	ORC1	206	Q13415
ETKEHIDTHRAIVAK	CC2D2A	956	Q9P2K1
VRHEELHRKIKDCTT	CCDC141	391	Q6ZP82
SEKHVRLEHLRIDVV	FBXL3	246	Q9UKT7
RLHVKHRLVSDVSAT	FNDC11	181	Q9BVV2
KPAVTRRSHRIKHEE	FAM172A	401	Q8WUF8
TDDKAVVLKRIHEVH	FOXRED1	256	Q96CU9
KLHHVDESVGSKTRR	ANKH	116	Q9HCJ1
RSVIHSHIKVIKTRK	IFI16	751	Q16666
RIVKVKGKRSSEHVH	EMC1	706	Q8N766
HQRKQEIKRLSTEHS	EPS8	466	Q12929
EKKHDTHRVEELERS	GOLGA8B	261	A8MQT2
AVHRHVLSVLSKTKE	GSS	161	P48637
KEVRHHRILEAKSIQ	FMN2	731	Q9NZ56
RESEIDKATEHKHTL	OSBPL11	686	Q9BXB4
TSLTKHLKRDHRELQ	UPF2	361	Q9HAU5
VTVKEALSTKARHIR	KIF13A	1366	Q9H1H9
SRVIEELHRALATKH	PHACTR3	291	Q96KR7
ATERHHRDVVELLIK	GABPB2	111	Q8TAK5
HVVDGKERTLLVHRK	RTCB	361	Q9Y3I0
TEEERTRKLKTHLQH	SYTL3	31	Q4VX76
EKHVKEVISQLTRVH	ERVW-1	126	Q9UQF0
LVEHRKEHVRKTIDD	URI1	116	O94763
TVHSDVERKKEIARL	OVCH2	491	Q7RTZ1
KHHTSKIREFADLTR	PMS2P2	151	O95744
SKAKNVHTHRVRERD	WAC	76	Q9BTA9
HRVLKSVESERHKQE	DZIP1	571	Q86YF9
STDVDVILRKHSDHR	ABHD10	266	Q9NUJ1
IVHIHSVIILRRSDK	BRCC3	71	P46736
VVTHHTLSRKKRADK	CLCA2	921	Q9UQC9
HKSSKVREVAATVHR	NCAPG2	1096	Q86XI2
VREVAATVHRKLKTF	NCAPG2	1101	Q86XI2
RSARLHEKKEHSTAE	RIOK3	216	O14730
TVRSHVKTHQEIKLD	XIRP2	2916	A4UGR9
ERSTLVRHQKVHTRE	ZNF132	666	P52740
SSHLTRHKVIHTEEK	ZNF99	661	A8MXY4
SSILTKHKRIHAREK	ZNF718	211	Q3SXZ3
VKHLQIHERTEKHIR	ZNF700	486	Q9H0M5
SIKRSRKIIFVITHH	TLR3	806	O15455
SSHLTRHKIIHTEEK	ZNF138	206	P52744
HTKLTRHQRIHSEEK	ZNF19	341	P17023
SIVHKARETLERAIK	REV3L	2751	O60673
LERHVRTHTREKKFT	SP7	341	Q8TDD2
KGTLTVHRRSHLEEK	RBAK	301	Q9NYW8
AFIRHRKVHTEEKSH	RBAK	471	Q9NYW8
VRERTTLKEHLRIHS	ZBTB41	556	Q5SVQ8
ESLHKTIVKRRMSHV	NF1	806	P21359
VRIEHIKHSKSRDSF	RPL21	91	P46778
SSVDRHHSVEIKIEK	SAFB2	506	Q14151
VVVHSRVHKRDRKGE	ZNF536	646	O15090
VVRHQRTHLEEKTIV	ZNF133	341	P52736
KSDLIRHRKTHTDEK	ZNF528	421	Q3MIS6
KSSVLTKHREVHVRE	ZKSCAN2	926	Q63HK3
KRDVIRHITVVHKKS	ZNF800	531	Q2TB10
RKSTIETHKRIHTGE	ZNF611	381	Q8N823
LEHLKHKHSRVREEV	TOGARAM1	476	Q9Y4F4
VVHLKKAHRRVHTSL	TEX15	1001	Q9BXT5
RSSTLTKHKRIHAEE	ZNF732	261	B4DXR9
FREKSELIKHQRIHT	ZNF589	341	Q86UQ0
RTGREKIFSKHVAHV	PRPF18	291	Q99633
SVLTKHQRIHTRVKA	ZNF248	561	Q8NDW4
SHRKCHRTRVEKVET	ZC3H13	1156	Q5T200
SLLTRHKIIHTREKR	ZNF836	511	Q6ZNA1
KSELITHQRIHTTEK	ZNF81	566	P51508
EVHRHKASLSRVKLA	TRPC3	286	Q13507
VKDLRIHERTHTGEK	ZNF878	351	C9JN71
RSSDLSKHKRIHTRE	ZNF311	426	Q5JNZ3
DFSIKAELTKHRRIH	ZNF311	451	Q5JNZ3
AELTKHRRIHTEEKR	ZNF311	456	Q5JNZ3
SSDLKRHVISVHTKD	ZFY	641	P08048
TRDTVHVKEVTKHVS	NEB	5671	P20929