Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

ATP6V1B2 MYO1D WRN COQ8B DDX1 DHX8 MDN1 KIF14 ACSBG2 DDX60L ABCC2 ATP2B1 SNRNP200 HSPA4 HELLS

1.64e-0561413415GO:0140657
GeneOntologyMolecularFunctionPDZ domain binding

CIT MUC17 KIF14 PLEKHA1 PLEKHA2 DLG2 ATP2B1

1.95e-051231347GO:0030165
GeneOntologyMolecularFunctionnuclease activity

POP4 AGO2 POLG WRN SAMHD1 SLFN14 DDX1 EXOSC4

1.70e-042311348GO:0004518
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

POP4 AGO2 FBL POLG WRN SAMHD1 SLFN14 DDX1 DHX8 DDX60L SNRNP200 EXOSC4 HELLS

4.07e-0464513413GO:0140640
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

POP4 AGO2 FBL SAMHD1 SLFN14 DDX1 DHX8 DDX60L SNRNP200 EXOSC4

5.18e-0441713410GO:0140098
GeneOntologyMolecularFunctioneukaryotic translation initiation factor 2alpha kinase activity

STK35 PDIK1L

6.59e-0461342GO:0004694
GeneOntologyMolecularFunctionhelicase activity

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

6.96e-041581346GO:0004386
GeneOntologyMolecularFunctionprotein domain specific binding

VPS11 MYO1D CIT UBR5 MUC17 SHCBP1 KIF14 PLEKHA1 PLEKHA2 DLG2 TRAK2 ABCC2 CACYBP ATP2B1 SOS1

7.94e-0487513415GO:0019904
GeneOntologyMolecularFunctionATP hydrolysis activity

WRN COQ8B DDX1 DHX8 MDN1 KIF14 DDX60L ABCC2 ATP2B1 SNRNP200

7.96e-0444113410GO:0016887
GeneOntologyBiologicalProcessinner ear receptor cell development

FAT4 CDH23 ADGRV1 TECTA USH1C KCNQ1

7.34e-06731326GO:0060119
GeneOntologyBiologicalProcessneuron development

PRTG DPYSL2 FAT4 GAK FN1 CDH23 ITGA1 ADGRV1 TECTA USH1C CIT PTPN5 IGF2BP1 EHD1 PLXNA4 KCNQ1 DLG2 ACTL6B TRAK2 SEMA4A FBXO45 TNR NCK2 SOS1

1.73e-05146313224GO:0048666
GeneOntologyBiologicalProcessneuron projection development

PRTG DPYSL2 FAT4 GAK FN1 CDH23 ITGA1 ADGRV1 TECTA USH1C CIT PTPN5 IGF2BP1 EHD1 PLXNA4 ACTL6B TRAK2 SEMA4A FBXO45 TNR NCK2 SOS1

2.14e-05128513222GO:0031175
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

FAT4 CDH23 ADGRV1 TECTA USH1C

2.23e-05531325GO:0060122
GeneOntologyBiologicalProcessinner ear receptor cell differentiation

FAT4 CDH23 ADGRV1 TECTA USH1C KCNQ1

3.55e-05961326GO:0060113
GeneOntologyBiologicalProcessmechanoreceptor differentiation

FAT4 CDH23 ADGRV1 TECTA USH1C KCNQ1

5.57e-051041326GO:0042490
GeneOntologyBiologicalProcessregulation of translational initiation by eIF2 alpha phosphorylation

STK35 PDIK1L NCK2

1.10e-04151323GO:0010998
GeneOntologyBiologicalProcessauditory receptor cell development

CDH23 TECTA USH1C KCNQ1

1.23e-04401324GO:0060117
GeneOntologyCellularComponentciliary pocket membrane

EHD3 EHD1

1.22e-0431342GO:0020018
GeneOntologyCellularComponentciliary pocket

EHD3 EHD1

1.22e-0431342GO:0020016
GeneOntologyCellularComponentcell body

DPYSL2 MYO1D ITGA1 CIT NMNAT3 PTPN5 IGF2BP1 SLC8A1 LNPEP SKOR1 KCNQ1 DLG2 TRAK2 CACYBP ATP2B1 SOS1

3.04e-0492913416GO:0044297
GeneOntologyCellularComponentneuronal cell body

DPYSL2 MYO1D ITGA1 CIT NMNAT3 PTPN5 IGF2BP1 SLC8A1 LNPEP SKOR1 KCNQ1 DLG2 TRAK2 ATP2B1 SOS1

3.05e-0483513415GO:0043025
GeneOntologyCellularComponentcell projection membrane

MYO1D PIEZO1 ADGRV1 EHD3 PTPRJ MUC17 EHD1 PLEKHA1 ABCC2 ATP2B1

4.70e-0443113410GO:0031253
GeneOntologyCellularComponentcluster of actin-based cell projections

MYO1D CDH23 ADGRV1 USH1C MUC17 PLEC ABCC2

5.97e-042231347GO:0098862
GeneOntologyCellularComponentstereocilia ankle link

ADGRV1 USH1C

6.02e-0461342GO:0002141
GeneOntologyCellularComponentstereocilia ankle link complex

ADGRV1 USH1C

6.02e-0461342GO:0002142
GeneOntologyCellularComponentbasal part of cell

MYO1D ITGA1 SLC7A7 SLC8A1 SLC14A1 KCNQ1 DLG2 PLEC ATP2B1

7.54e-043781349GO:0045178
GeneOntologyCellularComponentsomatodendritic compartment

DPYSL2 AGO2 MYO1D ITGA1 CIT NMNAT3 ABHD17C PTPN5 IGF2BP1 SLC8A1 LNPEP SKOR1 KCNQ1 DLG2 TRAK2 PLEC ATP2B1 SOS1

8.62e-04122813418GO:0036477
GeneOntologyCellularComponentstereocilia coupling link

ADGRV1 USH1C

1.11e-0381342GO:0002139
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

ACTL6A YEATS4 ACTL6B

1.12e-03321343GO:0035267
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

ACTL6A YEATS4 ACTL6B

1.12e-03321343GO:0043189
GeneOntologyCellularComponentcell leading edge

ATP6V1B2 MYO1D PIEZO1 ADGRV1 CIT IGF2BP1 PTPRJ PLEKHA1 ATP2B1 ARHGEF6

1.45e-0350013410GO:0031252
GeneOntologyCellularComponentapical part of cell

ATP6V1B2 FAT4 FN1 CDH23 USH1C CLCN5 MUC17 KCNQ1 PLEC ABCC2 ATP2B1

1.52e-0359213411GO:0045177
GeneOntologyCellularComponentperineuronal net

VCAN TNR

1.77e-03101342GO:0072534
GeneOntologyCellularComponentneuron to neuron synapse

DPYSL2 PTPRT ABHD17C USP6 SLC8A1 PLXNA4 DLG2 FBXO45 TNR NCK2

2.02e-0352313410GO:0098984
GeneOntologyCellularComponentbasal plasma membrane

MYO1D SLC7A7 SLC8A1 SLC14A1 KCNQ1 DLG2 PLEC ATP2B1

2.05e-033541348GO:0009925
GeneOntologyCellularComponentactin-based cell projection

ATP6V1B2 MYO1D CDH23 ADGRV1 USH1C IGF2BP1 MUC17

2.13e-032781347GO:0098858
GeneOntologyCellularComponentperisynaptic extracellular matrix

VCAN TNR

2.16e-03111342GO:0098966
MousePhenoabnormal hair cell mechanoelectric transduction

CDH23 ADGRV1 TECTA USH1C

3.06e-06141074MP:0004431
MousePhenoabnormal orientation of outer hair cell stereociliary bundles

FAT4 CDH23 ADGRV1 USH1C

3.06e-05241074MP:0004491
MousePhenoabnormal cochlear hair cell inter-stereocilial links morphology

CDH23 ADGRV1 USH1C

3.54e-0591073MP:0004577
MousePhenoabnormal vitelline vascular remodeling

FN1 PIEZO1 SLC8A1 PTPRJ UBR5

1.01e-04611075MP:0004076
MousePhenocochlear degeneration

POLG CDH23 ADGRV1 USH1C KCNQ1

1.09e-04621075MP:0000032
MousePhenocochlear ganglion degeneration

POLG CDH23 ADGRV1 USH1C KCNQ1

1.18e-04631075MP:0002857
MousePhenohead tossing

CDH23 USH1C KCNQ1 ATP2B1

1.42e-04351074MP:0005307
MousePhenoabnormal orientation of cochlear hair cell stereociliary bundles

FAT4 CDH23 ADGRV1 USH1C

1.42e-04351074MP:0004522
MousePhenoabsent atrioventricular cushions

SLC8A1 PTPRJ VCAN

1.49e-04141073MP:0000298
DomainCXorf40

EOLA1 EOLA2

5.11e-0521342IPR033615
DomainBig_2

NUP210L NUP210

5.11e-0521342PF02368
DomainInvasin/intimin_cell_adhesion

NUP210L NUP210

5.11e-0521342IPR008964
DomainBID_2

NUP210L NUP210

5.11e-0521342SM00635
DomainEHD1/EHD3

EHD3 EHD1

5.11e-0521342IPR029951
DomainBig_2

NUP210L NUP210

5.11e-0521342IPR003343
DomainPeptidase_M1_N

ERAP2 LNPEP TAF2

9.80e-05131343IPR014782
DomainPeptidase_M1

ERAP2 LNPEP TAF2

9.80e-05131343PF01433
DomainP-loop_NTPase

ATP6V1B2 MYO1D WRN SLFN14 DDX1 DHX8 EHD3 RAB36 GTPBP2 MDN1 EHD1 KIF14 DLG2 DDX60L ABCC2 SNRNP200 HELLS

1.21e-0484813417IPR027417
DomainHelicase_C

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.22e-041071346PF00271
DomainHELICc

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.22e-041071346SM00490
DomainHelicase_C

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.28e-041081346IPR001650
DomainHELICASE_CTER

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.35e-041091346PS51194
DomainHELICASE_ATP_BIND_1

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.35e-041091346PS51192
DomainDEXDc

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.35e-041091346SM00487
DomainHelicase_ATP-bd

WRN DDX1 DHX8 DDX60L SNRNP200 HELLS

1.42e-041101346IPR014001
DomainASCH_domain

EOLA1 EOLA2

1.53e-0431342IPR007374
DomainASCH

EOLA1 EOLA2

1.53e-0431342SM01022
DomainDEAD/DEAH_box_helicase_dom

WRN DDX1 DHX8 DDX60L SNRNP200

1.79e-04731345IPR011545
DomainDEAD

WRN DDX1 DHX8 DDX60L SNRNP200

1.79e-04731345PF00270
Domain-

ATP6V1B2 WRN SLFN14 DDX1 DHX8 EHD3 RAB36 GTPBP2 MDN1 EHD1 DLG2 DDX60L ABCC2 SNRNP200 HELLS

3.02e-04746134153.40.50.300
DomainEHD_N

EHD3 EHD1

5.04e-0451342IPR031692
DomainEHD_N

EHD3 EHD1

5.04e-0451342PF16880
DomainConA-like_dom

FAT4 NBEA ADGRV1 PTPRT DDX1 MMRN1 FBXO45

1.03e-032191347IPR013320
DomainCadherin_CS

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.13e-031091345IPR020894
DomainCADHERIN_1

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.33e-031131345PS00232
DomainCadherin

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.33e-031131345PF00028
DomainCADHERIN_2

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.39e-031141345PS50268
Domain-

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.39e-0311413452.60.40.60
DomainERAP1-like_C_dom

ERAP2 LNPEP

1.39e-0381342IPR024571
DomainCalx_beta

ADGRV1 SLC8A1

1.39e-0381342SM00237
DomainERAP1_C

ERAP2 LNPEP

1.39e-0381342PF11838
DomainCA

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.44e-031151345SM00112
DomainCadherin-like

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.50e-031161345IPR015919
DomainPlexin_repeat

PLXDC2 PLXNA4 SEMA4A

1.54e-03321343IPR002165
DomainPSI

PLXDC2 PLXNA4 SEMA4A

1.54e-03321343PF01437
DomainCadherin

FAT4 DSG3 CDH23 PCDHA4 CDH18

1.61e-031181345IPR002126
DomainCalx_beta

ADGRV1 SLC8A1

1.78e-0391342IPR003644
DomainCalx-beta

ADGRV1 SLC8A1

1.78e-0391342PF03160
DomainEGF-like_dom

FAT4 ADAM30 TECTA MMRN1 MUC17 VCAN TNR

2.15e-032491347IPR000742
DomainPTPc

PTPRT PTPN5 PTPRJ

2.17e-03361343SM00194
DomainEF-hand_4

EHD3 EHD1

2.21e-03101342PF12763
DomainZP_dom_CS

TECTA DMBT1

2.21e-03101342IPR017977
DomainSH3_9

PEX13 ARHGAP12 ARHGEF6 NCK2

2.40e-03781344PF14604
DomainEGF_1

FAT4 FN1 ADAM30 MMRN1 MUC17 VCAN TNR

2.46e-032551347PS00022
DomainEH

EHD3 EHD1

2.69e-03111342PS50031
DomainEH

EHD3 EHD1

2.69e-03111342SM00027
DomainEH_dom

EHD3 EHD1

2.69e-03111342IPR000261
DomainTYR_PHOSPHATASE_PTP

PTPRT PTPN5 PTPRJ

2.73e-03391343PS50055
DomainEGF-like_CS

FAT4 FN1 ADAM30 MMRN1 MUC17 VCAN TNR

2.80e-032611347IPR013032
DomainPTPase_domain

PTPRT PTPN5 PTPRJ

3.15e-03411343IPR000242
DomainY_phosphatase

PTPRT PTPN5 PTPRJ

3.15e-03411343PF00102
DomainPeptidase_M1

ERAP2 LNPEP

3.22e-03121342IPR001930
DomainPSI

PLXDC2 PLXNA4 SEMA4A

3.86e-03441343IPR016201
Domain-

GAK PTPRT PTPN5 PTPRJ

4.35e-039213443.90.190.10
DomainPSI

PLXDC2 PLXNA4 SEMA4A

4.38e-03461343SM00423
DomainG_DYNAMIN_dom

EHD3 EHD1

4.39e-03141342IPR030381
DomainZP_2

TECTA DMBT1

4.39e-03141342PS51034
DomainZP_1

TECTA DMBT1

4.39e-03141342PS00682
DomainG_DYNAMIN_2

EHD3 EHD1

4.39e-03141342PS51718
Domain-

AGO2 POLG WRN

4.65e-034713433.30.420.10
DomainDynamin_GTPase

EHD3 EHD1

5.05e-03151342IPR001401
DomainDynamin_SF

EHD3 EHD1

5.05e-03151342IPR022812
DomainDynamin_N

EHD3 EHD1

5.05e-03151342PF00350
DomainZP

TECTA DMBT1

5.05e-03151342SM00241
DomainProt-tyrosine_phosphatase-like

GAK PTPRT PTPN5 PTPRJ

5.64e-03991344IPR029021
DomainActin_CS

ACTL6A ACTL6B

5.74e-03161342IPR004001
DomainPH

CIT ARHGAP12 PLEKHA1 PLEKHA2 ARHGEF6 SOS1

6.22e-032291346PF00169
Domainfn3

PRTG FN1 PTPRT PTPRJ TNR

6.28e-031621345PF00041
DomainACTINS_2

ACTL6A ACTL6B

6.48e-03171342PS00432
DomainZP_dom

TECTA DMBT1

6.48e-03171342IPR001507
DomainZona_pellucida

TECTA DMBT1

6.48e-03171342PF00100
DomainSH3_1

PEX13 ARHGAP12 DLG2 ARHGEF6 NCK2

6.61e-031641345PF00018
DomainEGF

FAT4 TECTA MMRN1 MUC17 VCAN TNR

7.03e-032351346SM00181
DomainEGF_3

FAT4 ADAM30 MMRN1 MUC17 VCAN TNR

7.03e-032351346PS50026
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ATP6V1B2 DPYSL2 GAK AGO2 FN1 MYO1D NBEA NDUFA9 CIT DDX1 EHD3 VCAN EHD1 PLXNA4 DLG2 ACTL6B PLEC TNR ATP2B1 SNRNP200 HSPA4 NCK2

3.04e-0814311342237142655
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ATP6V1B2 AGO2 MYO1D NBEA CEP192 PTPRT PTPN5 YEATS4 PTPRJ LNPEP PRIM2 NUP210 KIF14 PLEKHA1 CACYBP ATP2B1 NCK2 HELLS

1.26e-0710491341827880917
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

FN1 FBL ACTL6A DDX1 MDN1 VCAN PLEC SNRNP200 HELLS

1.95e-07219134931353912
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

ATP6V1B2 MYO1D FBL ETFA CIT DDX1 DHX8 IGF2BP1 MDN1 UBR5 NUP210 KIF14 PLEC ATP2B1 SNRNP200 HSPA4 HELLS

4.60e-0710241341724711643
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

GAK ETFA COQ8B SAMHD1 ACTL6A ECPAS NDUFA9 DDX1 IGF2BP1 MDN1 MRPL15 UBR5 NUP210 EHD1 KIF14 DDX60L ATP2B1 SNRNP200 HSPA4 HELLS

6.88e-0714401342030833792
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

ATP6V1B2 GAK AGO2 FN1 ADGRV1 NDUFA9 UBR5 VCAN DLG2 TNR ATP2B1

9.57e-074301341132581705
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

CFAP47 DPYSL2 FAT4 FN1 COQ8B NBEA SAMHD1 ECPAS KDM4D MDN1 PLXNA4 OR4B1 TNR SNRNP200

1.05e-067361341429676528
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DPYSL2 AGO2 FN1 FBL ACTL6A MCCC2 NDUFA9 DDX1 MDN1 UBR5 PRIM2 SHCBP1 EHD1 DDX60L TAF2 PLEC ATP2B1 SNRNP200 HSPA4

1.14e-0613531341929467282
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

DPYSL2 GAK ETFA SAMHD1 ECPAS PTPN5 IGF2BP1 UBR5 LNPEP SHCBP1 NUP210 PRMT9 CACYBP ATP2B1 SNRNP200 HSPA4

1.18e-069741341628675297
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

FBL SAMHD1 ECPAS DDX1 IGF2BP1 MDN1 PRIM2 NUP210 PLEC CACYBP SNRNP200 HSPA4 HELLS

1.23e-066381341333239621
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

ATP6V1B2 VPS11 POP4 ETFA COQ8B ECPAS CIT MDN1 MRPL15 UBR5 PIGX PRIM2 NUP210 ATP2B1

1.40e-067541341433060197
Pubmed

Mapping the Genetic Landscape of Human Cells.

CEP192 ACTL6A NDUFA9 CIT MRPL15 PRIM2 KIF14 TAF2 SNRNP200 EXOSC4 SDHC

1.52e-064511341130033366
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DPYSL2 FN1 MYO1D FBL ECPAS DHX8 MDN1 UBR5 NUP210 KIF14 PLEC SNRNP200 HSPA4

1.59e-066531341322586326
Pubmed

Biochemical characterization of native Usher protein complexes from a vesicular subfraction of tracheal epithelial cells.

CDH23 ADGRV1 USH1C

1.94e-067134320058854
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

PRTG FN1 ITGA1 CIT DDX1 UBR5 NUP210

2.60e-06156134729961565
Pubmed

Microarray-based mutation analysis of 183 Spanish families with Usher syndrome.

CDH23 ADGRV1 USH1C

3.09e-068134319683999
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

CDH23 TECTA USH1C

3.09e-068134321165971
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ATP6V1B2 GAK PIEZO1 ETFA CEP192 MCCC2 NDUFA9 MDN1 MRPL15 UBR5 ERAP2 LNPEP NUP210 PLEKHA1 CACYBP ATP2B1 SNRNP200 HSPA4 HELLS

4.52e-0614871341933957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DPYSL2 AGO2 POLG ZG16B CEP192 MCCC2 ADGRV1 TECTA ECPAS INTS8 EHD3 AFMID PTPRJ PLXDC2 NUP210 PLEKHA2 SLC35F2 ATP2B1 NCK2

4.61e-0614891341928611215
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

MYO1D FBL SAMHD1 ECPAS NDUFA9 EHD1 ATP2B1 SOS1 HELLS

4.86e-06323134924797263
Pubmed

Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 1.

CDH23 ADGRV1 USH1C

6.58e-0610134324618850
Pubmed

Usher protein functions in hair cells and photoreceptors.

CDH23 ADGRV1 USH1C

6.58e-0610134324239741
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FAT4 AGO2 FBL NUP210L ACTL6A ECPAS YEATS4 UBR5 NUP210 KIF14 DMBT1 CACYBP SNRNP200

7.53e-067541341335906200
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

CDH23 TECTA USH1C

9.02e-0611134331776257
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MYO1D FBL ETFA SAMHD1 ACTL6A MCCC2 ECPAS DDX1 DHX8 IGF2BP1 MDN1 NUP210 KIF14 CACYBP ATP2B1 SNRNP200 HSPA4 HELLS

9.65e-0614251341830948266
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

DPYSL2 GAK AGO2 FBL ACTL6A MCCC2 YEATS4 KIF14 TAF2 CACYBP SNRNP200

9.83e-065491341138280479
Pubmed

Defining the membrane proteome of NK cells.

GAK AGO2 PEX13 ITGA1 ANO10 ECPAS CIT DDX1 MDN1 CLCN5 UBR5 LNPEP NUP210 EHD1 KIF14 ATP2B1

1.17e-0511681341619946888
Pubmed

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.

ACTL6A ACTL6B

1.47e-052134219561591
Pubmed

Assembling stable hair cell tip link complex via multidentate interactions between harmonin and cadherin 23.

CDH23 USH1C

1.47e-052134219297620
Pubmed

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.

PLEKHA1 PLEKHA2

1.47e-052134222777911
Pubmed

SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.

EHD3 EHD1

1.47e-052134226226295
Pubmed

A heart segmental defect in the anterior-posterior axis of a transgenic mutant mouse.

FN1 VCAN

1.47e-05213429188753
Pubmed

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.

PLEKHA1 PLEKHA2

1.47e-052134221204784
Pubmed

Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.

ACTL6A ACTL6B

1.47e-052134210380635
Pubmed

Deafness and retinal degeneration in a novel USH1C knock-in mouse model.

CDH23 USH1C

1.47e-052134220095043
Pubmed

Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D.

CDH23 USH1C

1.47e-052134211138009
Pubmed

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction.

CDH23 USH1C

1.47e-052134232249312
Pubmed

Dual inhibition of phosphoinositide 3-kinases delta and gamma reduces chronic B cell activation and autoantibody production in a mouse model of lupus.

PLEKHA1 PLEKHA2

1.47e-052134237234154
Pubmed

Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia.

CDH23 USH1C

1.47e-052134222879593
Pubmed

Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression.

FN1 VCAN

1.47e-052134223201264
Pubmed

Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates.

STK35 PDIK1L

1.47e-052134219756140
Pubmed

Expression and localization of myosin-1d in the developing nervous system.

MYO1D ASPA

1.47e-052134222284616
Pubmed

The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.

CDH23 USH1C

1.47e-052134212407180
Pubmed

MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.

AGO2 UBR5

1.47e-052134230651325
Pubmed

The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.

CDH23 ADGRV1

1.47e-052134215820310
Pubmed

Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells.

SLC8A1 ATP2B1

1.47e-052134212060584
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

AGO2 ETFA MCCC2 DPP3 ECPAS NDUFA9 DDX1 MDN1 PLEC CACYBP SNRNP200 HSPA4 MVD

1.54e-058071341330575818
Pubmed

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.

FBL ETFA ACTL6A DDX1 IGF2BP1 SNRNP200 HELLS

1.87e-05211134717314511
Pubmed

Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

ATP6V1B2 FN1 FBL ECPAS NDUFA9 DDX1 IGF2BP1 MDN1 NUP210 PLEC CACYBP SNRNP200

2.00e-057071341219738201
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

FBL ACTL6A ECPAS IGF2BP1 YEATS4 UBR5 TAF2 SNRNP200 HELLS

2.17e-05390134917643375
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

FBL ACTL6A DDX1 MDN1 SNRNP200 HSPA4 EXOSC4

2.24e-05217134731685992
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

ATP6V1B2 DPYSL2 ACTL6A CIT DDX1 IGF2BP1 MDN1 MRPL15 PLEC ATP2B1 SNRNP200 HSPA4 SDHC

2.55e-058471341335235311
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DPYSL2 AGO2 MYO1D ETFA CEP192 MCCC2 ECPAS MAST4 UBR5 ARHGAP12 KIF14 TAF2 PLEC

2.74e-058531341328718761
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

AGO2 FBL ETFA SAMHD1 ACTL6A MCCC2 NDUFA9 DDX1 IGF2BP1 MDN1 UBR5 NUP210 SNRNP200 HSPA4 EXOSC4 HELLS

2.86e-0512571341637317656
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

FAT4 MYO1D ETFA ADAM30 NBEA NDUFA9 USP6 MDN1 TAF2 ATP2B1 HELLS

3.90e-056381341131182584
Pubmed

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.

PLEKHA1 PLEKHA2

4.41e-053134211802782
Pubmed

Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes.

FN1 FBL

4.41e-053134211960984
Pubmed

Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea.

CDH23 TECTA

4.41e-053134229874579
Pubmed

Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.

ACTL6A ACTL6B

4.41e-053134212437990
Pubmed

Differential distribution of harmonin isoforms and their possible role in Usher-1 protein complexes in mammalian photoreceptor cells.

CDH23 USH1C

4.41e-053134214578428
Pubmed

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

EHD3 EHD1

4.41e-053134225686250
Pubmed

The oxytocinase subfamily of M1 aminopeptidases.

ERAP2 LNPEP

4.41e-053134216054015
Pubmed

CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation.

AGO2 IGF2BP1

4.41e-053134219647520
Pubmed

The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety.

VCAN TNR

4.41e-05313429294172
Pubmed

TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.

PLEKHA1 PLEKHA2

4.41e-053134212101241
Pubmed

An interstitial telomere array proximal to the distal telomere of mouse chromosome 13.

ETFA ITGA1

4.41e-05313429166585
Pubmed

Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma.

ERAP2 LNPEP

4.41e-053134215691326
Pubmed

Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.

EHD3 EHD1

4.41e-053134224019528
Pubmed

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.

CDH23 USH1C

4.41e-053134220639393
Pubmed

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

ERAP2 LNPEP

4.41e-053134221314638
Pubmed

Proteomic analysis of the enterocyte brush border.

MYO1D USH1C

4.41e-053134221330445
Pubmed

Photoreceptor expression of the Usher syndrome type 1 protein protocadherin 15 (USH1F) and its interaction with the scaffold protein harmonin (USH1C).

CDH23 USH1C

4.41e-053134215928608
Pubmed

EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.

EHD3 EHD1

4.41e-053134212121420
Pubmed

BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens.

ACTL6A ACTL6B

4.41e-053134227226355
Pubmed

Tetratricopeptide repeat domain 3 overexpression tends to form aggregates and inhibit ubiquitination and degradation of DNA polymerase γ.

POLG HSPA4

4.41e-053134229290964
Pubmed

Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.

ERAP2 LNPEP

4.41e-053134236716917
Pubmed

TGF beta in murine morphogenetic processes: the early embryo and cardiogenesis.

FN1 TNR

4.41e-05313421696875
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

MYO1D ETFA SAMHD1 NDUFA9 MDN1 UBR5 NUP210 EHD1 PLEC ATP2B1 HSPA4

4.42e-056471341126618866
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

FAT4 FN1 WRN NBEA CEP192 MCCC2 IGF2BP1 GTPBP2 UBR5 EHD1 SNRNP200 HELLS

4.99e-057771341235844135
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

ATP6V1B2 DPYSL2 FBL ETFA SAMHD1 ACTL6A NDUFA9 DDX1 EHD1 CACYBP SNRNP200

5.65e-056651341130457570
Pubmed

Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.

ETFA CDH23 MCCC2 EHD3 DLG2

6.68e-05109134529111324
Pubmed

Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex.

ACTL6A YEATS4 HSPA4

8.16e-0522134312963728
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

AGO2 SAMHD1 DHX8 PDIK1L VCAN CACYBP ATP2B1 HSPA4

8.68e-05363134825036637
Pubmed

A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.

ERAP2 LNPEP

8.80e-054134224957906
Pubmed

Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.

CDH23 USH1C

8.80e-054134216481439
Pubmed

Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.

EHD3 EHD1

8.80e-054134216251358
Pubmed

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.

TECTA USH1C

8.80e-054134218849963
Pubmed

Actin-related proteins.

ACTL6A ACTL6B

8.80e-054134210611965
Pubmed

C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?

EHD3 EHD1

8.80e-054134216155252
Pubmed

EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.

EHD3 EHD1

8.80e-054134227189942
Pubmed

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.

PLEKHA1 PLEKHA2

8.80e-054134214516276
Pubmed

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.

EHD3 EHD1

8.80e-054134229212907
Pubmed

Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.

EHD3 EHD1

8.80e-054134215020713
Pubmed

Role for a novel Usher protein complex in hair cell synaptic maturation.

CDH23 ADGRV1

8.80e-054134222363448
Pubmed

Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations.

FN1 VCAN

8.80e-05413429676579
Pubmed

B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice.

PLEKHA1 PLEKHA2

8.80e-054134227859053
Pubmed

Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.

CDH23 ADGRV1

8.80e-054134233009420
Pubmed

ATP-binding cassette transporter isoform C2 localizes to the apical plasma membrane via interactions with scaffolding protein.

ABCC2 HSPA4

8.80e-054134221059598
Pubmed

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.

EHD3 EHD1

8.80e-054134217233914
Pubmed

130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus.

EOLA1 EOLA2

8.80e-05413428717057
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CDH23 SAMHD1 SLC7A7 SLC8A1 PTPRJ PLXDC2 PIGX VCAN

1.71e-0720013488872d5fa101d413fb43b4231d476878678543035
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRTG SGCD SLC8A1 SHCBP1 ASPA KCNQ1 DLG2

6.16e-071621347285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellHealthy/Control-Plasmablast|Healthy/Control / Disease group and Cell class

MYO1D SLC41A2 IGF2BP1 SHCBP1 KIF14 SLC35F2 MFSD3

9.96e-07174134797d19ef3240a1f648c6befaabb9ce45ad469cbce
ToppCellCOVID_vent-Myeloid-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

DPYSL2 SAMHD1 SLC41A2 SLC8A1 CLCN5 PLXDC2 ATP2B1

1.55e-06186134763a5cdd3f60681762a218be32db84be8f29b88fd
ToppCellCOVID_vent-Myeloid-Dendritic-cDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

DPYSL2 SAMHD1 SLC41A2 SLC8A1 CLCN5 PLXDC2 ATP2B1

1.55e-06186134739457a7b43537f2c3e221f9375c95d4515424d7d
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT4 FN1 SGCD ITGA1 PLXDC2 VCAN ASPA

2.06e-061941347011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)|Adult / Lineage, Cell type, age group and donor

ATP6V1B2 SAMHD1 SLC8A1 PLXDC2 VCAN DDX60L ATP2B1

2.13e-06195134755e25f702af19146a161861cfd15f40bbda1dc35
ToppCellControl-Lymphoid-Proliferating_CD4_T_cells|Lymphoid / Condition, Lineage and Cell class

FN1 SLC7A7 CIT SLC8A1 PLXDC2 VCAN KIF14

2.13e-061951347578bbb06a5476c08fc3b351cc580c551dfe53ae4
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 PLXDC2 VCAN PLEC

2.20e-06196134728e9e191361966df3a9bd48450090577aa72a999
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 SGCD MAST4 PLXDC2 VCAN ASPA

2.20e-0619613471450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCelldistal-1-Hematologic-Interstitial_Macrophage|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP6V1B2 FN1 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

2.28e-0619713479e5df74aeeefa4d928ec07c036aacb549c797f30
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 SGCD MAST4 PLXDC2 VCAN ASPA

2.28e-06197134711a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

FAT4 FN1 SGCD CDH23 PLXDC2 VCAN DLG2

2.28e-061971347f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

SAMHD1 SLC7A7 SLC8A1 PTPRJ PLXDC2 VCAN DDX60L

2.35e-061981347ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellsystemic_lupus_erythematosus-flare-Myeloid|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

2.35e-061981347189346c5eb715f3be427bec3b8e067ababb5b475
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 SGCD MAST4 PLXDC2 VCAN ASPA

2.35e-06198134717dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCelldistal-Hematologic-Interstitial_Macrophage|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP6V1B2 FN1 SLC7A7 SLC8A1 PLXDC2 VCAN SEMA4A

2.35e-061981347a35b43d38e18c6f8f0cd9015b8e23f71c729f023
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

SAMHD1 SLC8A1 PLXDC2 VCAN PLEKHA2 DDX60L ATP2B1

2.35e-0619813479bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellFetal_29-31_weeks-Mesenchymal|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT4 FN1 SGCD ITGA1 PLXDC2 VCAN ASPA

2.35e-06198134721cf4d81386761d09d0f6829c01c198e5524176d
ToppCell3'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL2 FAT4 FN1 NBEA TM6SF1 SLC8A1 MAST4

2.43e-0619913470075bcc7d2a5031e76a24cb176e16ac998d846fd
ToppCellsevere_influenza-Classical_Monocyte|World / disease group, cell group and cell class (v2)

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

2.43e-061991347b8adbd6ff5e5602259118a69fd7c77e8348a27e4
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R--|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO1D DSG3 ADGRV1 PLEKHA2 DLG2 ATP2B1 CDH18

2.52e-062001347dc8702e3cb4ac8c1a9849fc8abf8777f12d55b0b
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R---L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO1D DSG3 ADGRV1 PLEKHA2 DLG2 ATP2B1 CDH18

2.52e-062001347d92d51021ab6d78e9c8f89f7c150181004dcbcbd
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R-|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO1D DSG3 ADGRV1 PLEKHA2 DLG2 ATP2B1 CDH18

2.52e-062001347cbbb9044283ff9ab63bbfc24d7a9f006b1372705
ToppCellmetastatic_Lymph_Node-Myeloid_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

ATP6V1B2 FN1 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

2.52e-062001347d0824e6ba32aaaaa398379fdbbc282e890ef154c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 SGCD SAMHD1 SLC8A1 PLXDC2 VCAN ASPA

2.52e-0620013473dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 FN1 SGCD SAMHD1 PLXDC2 VCAN DLG2

2.52e-062001347c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R|Neuronal / cells hierarchy compared to all cells using T-Statistic

MYO1D DSG3 ADGRV1 PLEKHA2 DLG2 ATP2B1 CDH18

2.52e-062001347a3e36bbeed19431d07bc205f14f4e0f12bd8f730
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CDH23 SAMHD1 SLC7A7 SLC8A1 PTPRJ PIGX VCAN

2.52e-062001347fc061de0db2e8b5ca47f5e2a1e861018e7f1b582
ToppCellNasal_Brush-Epithelial-Basal_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DPYSL2 FN1 EHD3 PLXDC2 SLC35F2 SEMA4A

1.37e-05172134658eaadf12366701103a0d1f133462c9495fedc30
ToppCellHealthy/Control-Plasmablast|World / Disease group and Cell class

MYO1D SLC41A2 IGF2BP1 SHCBP1 SLC35F2 MFSD3

1.37e-051721346d3bfcf5d936152b71cd90f955f9331709edd979e
ToppCellNasal_Brush-Epithelial-Basal_1|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

DPYSL2 FN1 EHD3 PLXDC2 SLC35F2 SEMA4A

1.37e-0517213464483073469001770015526303772fd54906c5d68
ToppCellfacs-BAT-Fat-3m-Myeloid-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V1B2 FN1 TM6SF1 SLC8A1 VCAN SEMA4A

1.37e-0517213465f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V1B2 FN1 ITGA1 SLC8A1 VCAN SEMA4A

1.51e-05175134669b59ec58e64644deb7e07f31ef495ef4a6f6276
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP6V1B2 FN1 ITGA1 SLC8A1 VCAN SEMA4A

1.51e-0517513464f7498b5a0ed52c348a5f94bcd41d830ba7954ea
ToppCellMonocytes-IFN-activated_Monocytes|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

FN1 ZG16B RAB36 VCAN DLG2 DDX60L

1.56e-0517613466a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCellmetastatic_Brain-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

EOLA1 CDH23 NBEA PTPRJ PLXNA4 PRMT9

1.61e-05177134643e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 AFMID MAST4 ASPA DLG2 ABCC2

1.95e-051831346facd6dbe0851b537d70a899ac7485714ab27d071
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C MAST4 ASPA DLG2 ABCC2

1.95e-05183134684b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

PRTG FAT4 SAMHD1 TM6SF1 PLXDC2 DLG2

2.01e-05184134667164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellmoderate-Lymphoid-NK|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PRTG FAT4 FN1 SGCD ASPA RNF133

2.07e-0518513464979a787acbc9b4ca8defe91cc79b674e51af1bf
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell|TCGA-Uvea / Sample_Type by Project: Shred V9

FN1 MCCC2 DGLUCY MRPL15 SHCBP1 HSPA4

2.13e-051861346e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCelldroplet-Marrow-BM-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 FN1 ITGA1 NUP210 PLEC ATP2B1

2.13e-051861346bcb3ac9f9b51346e0a2b0bda96d149b3c11f7883
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C AFMID MAST4 ASPA ABCC2

2.20e-051871346dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C AFMID MAST4 ASPA ABCC2

2.20e-051871346f1356273bd3587b6883295edf15cb9cdb706c057
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C AFMID MAST4 ASPA ABCC2

2.26e-051881346f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C AFMID MAST4 ASPA ABCC2

2.26e-0518813460792432cd4c564dea1102241ea9884f7ced7658c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C MAST4 ASPA DLG2 ABCC2

2.33e-051891346204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

SGCD SMYD2 DGLUCY SLC8A1 MAST4 DLG2

2.33e-0518913465e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A7 USH1C MAST4 ASPA DLG2 ABCC2

2.33e-05189134613fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRTG PIEZO1 SHCBP1 ASPA PLEKHA2 DLG2

2.33e-051891346fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CEP192 CIT PRIM2 SHCBP1 KIF14 HELLS

2.40e-051901346d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellAdult-Immune-monocyte-D175|Adult / Lineage, Cell type, age group and donor

SAMHD1 SLC7A7 SLC8A1 PTPRJ PLXDC2 DDX60L

2.47e-051911346cbebb4d9550fdcd606cb3685ac9546c6b73fd422
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

SAMHD1 SLC7A7 SLC8A1 PTPRJ PLXDC2 DDX60L

2.55e-051921346733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC7A7 SLC8A1 CLCN5 PLXDC2 VCAN SEMA4A

2.62e-051931346d845beb0915a5b4bbd1e8f9b8d9322527a822849
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CEP192 CIT PRIM2 SHCBP1 KIF14 HELLS

2.62e-0519313464b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

FAT4 FN1 SGCD ITGA1 PLXDC2 DLG2

2.62e-051931346e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FN1 SGCD MAST4 PLXDC2 VCAN ASPA

2.70e-051941346a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FN1 SGCD PLXDC2 VCAN KCNQ1 CDH18

2.70e-05194134685e00861c5068a27d0cf0ae677f420c8245baa9a
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

CFAP47 MYO1D NBEA CFAP43 PTPRT MAST4

2.78e-051951346fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FAT4 FN1 MAST4 PLXDC2 VCAN ASPA

2.78e-0519513461cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CDH23 SAMHD1 TM6SF1 SLC8A1 PLXDC2 VCAN

2.78e-05195134662dc745e1aa3e2e58afa16c7bb2cf9b03d4e8105
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

CFAP47 MYO1D NBEA CFAP43 PTPRT MAST4

2.78e-051951346eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_monocytic|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN PLEC

2.86e-05196134689ff93cbfbe39fbdf2498e8fdc5d61a0ecb26fc9
ToppCellAdult-Immune-monocyte|Adult / Lineage, Cell type, age group and donor

CDH23 SAMHD1 SLC8A1 PLXDC2 PIGX VCAN

2.86e-0519613463ef193c5180de3137daf886492e74fc574bc9767
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid-myeloid_monocytic-monocyte|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN PLEC

2.86e-05196134609574bfeb1d3da53b5471cfb0602946d328b3b5c
ToppCell(7)_Monocyte|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ATP6V1B2 DPYSL2 SLC7A7 SLC8A1 PLXDC2 VCAN

2.86e-0519613460232167559dcd2d86ee8b78017cf5f2a084b2cb7
ToppCell(3)_MNP|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ATP6V1B2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

2.86e-051961346c79403da5443710a6caf035a279e42bc324b27c9
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ATP6V1B2 SAMHD1 SLC8A1 PLXDC2 VCAN PLEC

2.94e-051971346e2c53742c7d8d1b63d93843f82330b9e20f1faa6
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 FN1 SGCD ITGA1 SLC8A1 PLXDC2

2.94e-0519713460dd71e399f253787fa546a7e90c5373180b89ffd
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FN1 SGCD MAST4 PLXDC2 VCAN ASPA

2.94e-05197134631a1852911bda38543916585fda34255fd62a134
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

SGCD CDH23 TKTL1 ADGRV1 MAST4 NUP210

2.94e-05197134661749ccafeb938c310cff1de5ff924a1c794325a
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

SLC7A7 SLC8A1 PTPRJ PLXDC2 VCAN DDX60L

2.94e-051971346a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellInfluenza_Severe-Classical_Monocyte|World / Disease group and Cell class

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 PLXDC2 VCAN

2.94e-051971346e9a01f0fbbeaf6b23bce4603f62053c003848da4
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-classical_monocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 PLXDC2 VCAN

2.94e-051971346ffaf2d7b6aa82008bd64a691b48113626343872c
ToppCellsevere-T/NK_proliferative|World / disease stage, cell group and cell class

CIT YEATS4 SHCBP1 KIF14 CACYBP HELLS

2.94e-0519713466b7b068b103fd4f6ceda8e01f4dd39eefc3b3633
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

SGCD CDH23 TKTL1 ADGRV1 MAST4 NUP210

2.94e-0519713469d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-classical_monocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 PLXDC2 VCAN

2.94e-05197134694e2cc7ec531e58b8ed7e5601fdf8c4bbc3582c8
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-myeloid_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ATP6V1B2 SAMHD1 SLC8A1 PLXDC2 VCAN PLEC

2.94e-0519713469838dbd1623babf8de7e9126a28fe5d3666bce42
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FN1 SGCD MAST4 PLXDC2 VCAN ASPA

2.94e-0519713460034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell(7)_MNP|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ATP6V1B2 DPYSL2 SLC7A7 SLC8A1 PLXDC2 VCAN

2.94e-0519713466790346736946984cc80d67668523ba70ab0b380
ToppCelldistal-Hematologic-Interstitial_Macrophage-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP6V1B2 FN1 SLC7A7 SLC8A1 PLXDC2 VCAN

2.94e-0519713463b859c3bbb71858b97ce670bd507e67c377b88eb
ToppCellBLOOD--(3)_Classical_Mono-2| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DPYSL2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

3.03e-05198134634c23181c227f65209cde4382248253282f6ac6e
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D231|Adult / Lineage, Cell type, age group and donor

SAMHD1 SLC8A1 PLXDC2 VCAN DDX60L ATP2B1

3.03e-05198134679a415e19cedde13a88f5043d71557363f102322
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-classical_monocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ATP6V1B2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

3.03e-051981346c79c1738560d78b63dbed5f2f9621dbc1c2363cb
ToppCellsystemic_lupus_erythematosus-treated-Myeloid-classical_monocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ATP6V1B2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

3.03e-0519813461d1c80569f1e307285ba0ebaf5c72e0b5b538864
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma|TCGA-Breast / Sample_Type by Project: Shred V9

ACTL6A INTS8 SHCBP1 KIF14 CACYBP FBXO45

3.03e-051981346880f9817f5145f10f29fc05c5866090433532fe2
ToppCellsystemic_lupus_erythematosus-treated-Myeloid|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ATP6V1B2 SAMHD1 SLC7A7 SLC8A1 PLXDC2 VCAN

3.03e-051981346f37578f156e8aed2ce30cfa837ae04dd18de05d0
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic-granulocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DPYSL2 SAMHD1 CIT SHCBP1 KIF14 HELLS

3.03e-0519813462e669da80363163b806f23a645474d482797ae5d
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

FN1 SGCD PLXDC2 VCAN PLXNA4 DLG2

3.03e-051981346df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellcontrol-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ATP6V1B2 DPYSL2 SLC7A7 SLC8A1 PLXDC2 VCAN

3.03e-05198134635499a5231818e3432cf69b5c4a58c02f7771db8
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DSG3 CIT PTPRT SHCBP1 KIF14 HELLS

3.03e-051981346f088badb90c6c2d916195f5649eda102119c9ac6
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAT4 FN1 SGCD SAMHD1 PLXDC2 VCAN

3.03e-0519813467582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV-2|World / Primary Cells by Cluster

DPYSL2 TM6SF1 SLC8A1 DLG2 TNR ATP2B1

3.11e-051991346f09b40245d3d826275bbe5f508dedccc75a911bd
ToppCellInfluenza_Severe-Classical_Monocyte|Influenza_Severe / Disease group and Cell class

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 PLXDC2 VCAN

3.11e-051991346077ace6e0faedb8c701fcb227427204678867237
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATP6V1B2 DPYSL2 SLC7A7 SLC8A1 PLXDC2 VCAN

3.11e-0519913464fc03377c017209111561789226621d258291481
ToppCell18-Airway-Mesenchymal-Mesenchyme_RSPO2+|Airway / Age, Tissue, Lineage and Cell class

FN1 PLXDC2 VCAN SHCBP1 ASPA KIF14

3.11e-0519913467ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ATP6V1B2 DPYSL2 SAMHD1 SLC7A7 PLXDC2 VCAN

3.11e-0519913467dde5c02fcae64cd2d68f607500f2a46b97851fd
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV|World / Primary Cells by Cluster

DPYSL2 TM6SF1 SLC8A1 DLG2 TNR ATP2B1

3.11e-051991346e45448ec4db8875c8aaa9aad109a10e2905a4226
ToppCell3'_v3-Lung-Myeloid_Mac|Lung / Manually curated celltypes from each tissue

DPYSL2 FN1 SAMHD1 SLC7A7 SLC8A1 PLXDC2

3.11e-0519913461677aaee5b7f5f262e27df5d9f1bdf6e21e3d804
Drugchlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A_EA

GAK PIEZO1 DHX8 EHD3 NUP210 EHD1 PLEC ATP2B1 HSPA4

2.83e-0619913491055_DN
Diseaseendoplasmic reticulum aminopeptidase 2 measurement

ERAP2 LNPEP

1.90e-0521292EFO_0801566
DiseaseSeizures

POLG NBEA SAMHD1 SLC8A1 GTPBP2 ACTL6B ABCC2

5.09e-052181297C0036572
Diseasediverticular disease

PIEZO1 ETFA CPA3 SMYD2 AFMID PLEKHA1 DLEC1

8.37e-052361297EFO_0009959
Diseasecortical thickness

PRTG DPYSL2 NUP210L CPA3 ADGRV1 TM6SF1 USH1C IGF2BP1 GTPBP2 MAST4 PLXDC2 VCAN ARHGAP12 DLEC1 PLEC

1.09e-04111312915EFO_0004840
DiseaseUsher syndrome, type 1A

CDH23 USH1C

1.88e-0451292C2931205
DiseaseUSHER SYNDROME, TYPE IB (disorder)

CDH23 USH1C

1.88e-0451292C1848638
DiseaseUSHER SYNDROME, TYPE IA, FORMERLY

CDH23 USH1C

1.88e-0451292C1848639
DiseaseUSHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY

CDH23 USH1C

1.88e-0451292C1848640
DiseaseUsher syndrome type 1

CDH23 USH1C

1.88e-0451292cv:C1568247
Diseasecardiovascular disease

DPYSL2 WRN ABHD17C IGF2BP1 YEATS4 ERAP2 DLG2 ATP2B1 HSPA4

1.89e-044571299EFO_0000319
DiseaseUsher Syndrome, Type I

CDH23 USH1C

2.81e-0461292C1568247
DiseaseQRS duration

FAT4 SLC8A1 PTPRJ UBR5 KCNQ1 DLG2 DLEC1

3.49e-042981297EFO_0005055
DiseaseDisorder of eye

CDH23 ADGRV1 USH1C VCAN SEMA4A SNRNP200

3.50e-042121296C0015397
DiseaseHereditary retinal dystrophy

CDH23 USH1C

3.93e-0471292C0154860
DiseaseUsher syndrome

CDH23 USH1C

3.93e-0471292cv:C0271097
Diseasepleckstrin homology domain-containing family A member 1 measurement

PLEKHA1 DMBT1

3.93e-0471292EFO_0802873
Diseaseendoplasmic reticulum aminopeptidase 1 measurement

ERAP2 LNPEP

3.93e-0471292EFO_0008119
Diseasejoint hypermobility measurement

PRTG PIEZO1 VCAN

4.05e-04331293EFO_0007905
DiseaseNonsyndromic Deafness

CDH23 ADGRV1 TECTA USH1C

4.47e-04811294C3711374
Diseasesevere pre-eclampsia (is_marker_for)

ERAP2 LNPEP

5.22e-0481292DOID:13129 (is_marker_for)
Diseaseage-related hearing impairment

AGO2 CDH23 DGLUCY PLXNA4 DLG2 DLEC1 CDH18

5.75e-043241297EFO_0005782
Diseaselymphocyte count

FN1 MYO1D SGCD PIEZO1 CDH23 PEX13 SAMHD1 ITGA1 TM6SF1 PTPRT SMYD2 RAB36 PTPRJ DDX60L DMBT1 PLEC

6.68e-04146412916EFO_0004587
DiseaseNephroblastoma

DDX1 DLG2

8.34e-04101292Orphanet_654
Diseasehearing impairment

CDH23 ADGRV1 TECTA USH1C

9.17e-04981294C1384666
Diseasestatus epilepticus (biomarker_via_orthology)

DPYSL2 POLG SLC8A1 ABCC2

9.89e-041001294DOID:1824 (biomarker_via_orthology)
Diseasemortality

GAK POP4 POLG ABHD17C DHX8

1.00e-031731295EFO_0004352
Diseasecampesterol measurement

SLC7A7 MMRN1

1.02e-03111292EFO_0020008
Diseasedepressive symptom measurement, stressful life event measurement

MCCC2 YEATS4 KCNQ1

1.38e-03501293EFO_0007006, EFO_0007781
Diseasekynurenic acid measurement

SLC7A7 PIGX

1.43e-03131292EFO_0010506
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

CDH23 TECTA USH1C

1.46e-03511293cv:CN043650
Diseaseneuroimaging measurement, brain volume measurement

DPYSL2 RAB36 MAST4 VCAN DLG2 PLEC

1.65e-032861296EFO_0004346, EFO_0006930
Diseaselymphocyte measurement

PIEZO1 ITGA1 NUP210 ACTL6B

1.77e-031171294EFO_0803546
Diseasephosphatidylcholine 36:3 measurement

STK35 TNR

1.92e-03151292EFO_0010381
Diseasebrain connectivity measurement

DPYSL2 ADGRV1 STK35 VCAN PLEC CDH18 SOS1

1.94e-034001297EFO_0005210
Diseasenervousness

ETFA PTPRJ

2.19e-03161292NCIT_C74532
Diseasecoronary artery disease

VPS11 FAT4 FN1 SGCD ITGA1 IGF2BP1 MAST4 PTPRJ LNPEP PRIM2 NUP210 DLEC1 ATP2B1

2.24e-03119412913EFO_0001645
Diseasereticulocyte measurement

MYO1D PIEZO1 TKTL1 ITGA1 SLFN14 ECPAS EHD3 PTPRJ SLC14A1 KCNQ1 ATP2B1 HSPA4

2.29e-03105312912EFO_0010700
DiseaseAstrocytosis

ITGA1 TNR

2.47e-03171292C3887640
DiseaseGliosis

ITGA1 TNR

2.47e-03171292C0017639
DiseaseGlobal developmental delay

NBEA ACTL6A GTPBP2 ACTL6B

2.81e-031331294C0557874
DiseaseAbnormality of refraction

MYO1D PCDHA4 NBEA TKTL1 STK35 PTPN5 SLC8A1 DLG2 DLEC1

2.87e-036731299HP_0000539
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

PTPRJ SEMA4A

3.09e-03191292C1333991
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

PTPRJ SEMA4A

3.09e-03191292C2936783
Diseasealcohol consumption measurement

SGCD NBEA SAMHD1 DPP3 ADGRV1 CIT MMRN1 IGF2BP1 SLC8A1 MAST4 PTPRJ PLXNA4 CDH18

3.15e-03124212913EFO_0007878
Diseasecoagulation factor V measurement

MAST4 PLXDC2

3.42e-03201292EFO_0008087
DiseaseHereditary hearing loss and deafness

CDH23 TECTA USH1C KCNQ1

3.93e-031461294cv:C0236038
Diseasecognitive function measurement

AGO2 NUP210L PIEZO1 WRN NBEA CEP192 PTPRT IGF2BP1 MAST4 PLXNA4 PLEKHA1 TAF2 TNR SOS1

4.08e-03143412914EFO_0008354
DiseaseAutosomal Recessive Primary Microcephaly

CIT KIF14

4.14e-03221292C3711387

Protein segments in the cluster

PeptideGeneStartEntry
GVDSPIGKVVVSAVY

USH1C

471

Q9Y6N9
VLIYTSGTTGIPKGV

ACSBG2

226

Q5FVE4
PYAGFVLNGIKTVET

EOLA1

11

Q8TE69
PYAGFVLNGIKTVET

EOLA2

11

Q96DE9
PVTLVYQKEGVLASG

CFAP43

306

Q8NDM7
VTQEDLVIGGYLIPK

CYP27C1

421

Q4G0S4
IYQGKIPIAGTVVTR

ARHGEF6

491

Q15052
VIAGTLGQVKPYSSV

PRMT9

596

Q6P2P2
IKIGQDYKGRVSVPT

VCAN

91

P13611
DGYVLQQGIVKSPLA

ACTL6B

181

O94805
IYTVPEVGTVVGGTL

GTPBP2

416

Q9BX10
LNIYSVQISEGVPIG

FAT4

3406

Q6V0I7
YVLQQGIVKSPLAGD

ACTL6A

186

O96019
LIGEPSAKYNGTAII

ADGRV1

4161

Q8WXG9
SGLGAKIPVTIITGY

CBWD5

36

Q5RIA9
EGIPAGVSIYQVVAI

CDH23

901

Q9H251
VPGIGAVFQIYIIKD

CIT

1626

O14578
TVGDIAQVKYGDLLP

ATP2B1

211

P20020
TYAGLQLVVVILPGK

AGO2

511

Q9UKV8
VVVVGDLYVGKTSLI

RAB36

126

O95755
PSVYSGVILGIKDNL

INTS8

551

Q75QN2
VVIVAYGIAPKGTLD

AFMID

121

Q63HM1
EKVYIATQGPIVSTV

PTPN5

366

P54829
VLGINSITGKEEPLY

ANO10

291

Q9NW15
VVKAVDPTSGQLYGL

NUP210

1256

Q8TEM1
QKITYRISGVGIDQP

DSG3

81

P32926
PVGTAVLYLTGIEVS

PADI6

111

Q6TGC4
IEQGNTKALAVVYGP

EXOSC4

41

Q9NPD3
GGTVSIIPVGEAKTY

KIF14

856

Q15058
PIKAYAVILTTGEAG

PTPRJ

846

Q12913
IGQTKPVVVYRLVTA

HELLS

711

Q9NRZ9
GVVTVTTIGYGDKVP

KCNQ1

306

P51787
GTYPVLIQGETSVGK

MDN1

1076

Q9NU22
IVQLPTGLTGIKVTY

HSPA4

91

P34932
CAQVPKITLIIGGSY

MCCC2

431

Q9HCC0
RGQVGLVPKNYVVVL

NCK2

241

O43639
QARKKGTVVYGEPIT

DPYSL2

266

Q16555
TVILDNQVTYVPGGK

MMRN1

221

Q13201
LVPTQYVGAIIGKEG

IGF2BP1

201

Q9NZI8
SDVGVVVYVAPAKSL

DDX60L

786

Q5H9U9
VVYVAPAKSLVGQVA

DDX60L

791

Q5H9U9
SGLGAKIPVTIITGY

CBWD2

36

Q8IUF1
SGLGAKIPVTIITGY

CBWD1

36

Q9BRT8
GKTGAFSIPVIQIVY

DDX1

51

Q92499
KSGETNPVQIYIGLL

ECPAS

646

Q5VYK3
PVAGGNVKLNYTVLV

PLXNA4

1171

Q9HCM2
PIVYGVKTKQIREGV

OR52B2

291

Q96RD2
AAVVAPITTGYTVKI

CACYBP

61

Q9HB71
RKGYSVPKVGTVQVT

FAM214B

416

Q7L5A3
LVTKNLVPGESVYGE

FBL

106

P22087
LYGAILPQVVTAGTI

POLG

836

P54098
KECGVVIEGVNTPYL

KDM4D

166

Q6B0I6
EPTPGGVKYIIVTQV

MVD

361

P53602
IQDKGPIVESYIGFI

DPP3

301

Q9NY33
TLVSIYAVPEKIGQV

LNPEP

376

Q9UIQ6
TVGYGDVVPVTVAGK

KCNS1

421

Q96KK3
IVVLGNGTIVEKGSY

ABCC2

831

Q92887
DIGPKQTQVGIVQYG

ITGA1

201

P56199
ELGPGNTVQVVAYKL

MFSD3

131

Q96ES6
VKQPVYVVDVSKGIV

NDUFA9

236

Q16795
RSGKIIPGQVYIEVE

ARHGAP12

6

Q8IWW6
SRGAPVSVYQLVVKE

PTPRT

616

O14522
KGGTDLIINSYGPII

PRTG

1031

Q2VWP7
YKISPGGISQILDLV

PRIM2

401

P49643
DPITGQIIVKGYIDF

PCDHA4

296

Q9UN74
PLGVTVQGDVLIVIY

GAK

631

O14976
QGVVSPVSYLLQLKG

ADAM30

56

Q9UKF2
QKVYVIGGIATNVRP

KLHL28

331

Q9NXS3
GSTVEDNPLYVLKIG

CPA3

146

P15088
GNTEVTLVYLGKPLD

FBXO45

271

P0C2W1
LKPGVVYEGQLISIQ

FN1

671

P02751
DAVVRGYSIPKGTTV

CYP2R1

386

Q6VVX0
KGLKIPQLYQSGVVV

SDHC

141

Q99643
QLGKYPVIEVLVVTA

CLCN5

421

P51795
SGLGAKIPVTIITGY

CBWD3

36

Q5JTY5
SGLGAKIPVTIITGY

CBWD6

36

Q4V339
ILYGQSIGTVPTVDL

ABHD17C

206

Q6PCB6
GTEVAVKIQYPGIAQ

COQ8B

231

Q96D53
EGQGIKTDIPRYIIS

MAST4

506

O15021
PQYEVVLKGEVISSG

CEP192

1736

Q8TEP8
YVPESAQVGSAVGKI

CDH18

276

Q13634
IPTDVLKIVYSVGAQ

ERAP2

786

Q6P179
IPGDNSIYVTKIIDG

DLG2

216

Q15700
LKTQIPILTYQGGSV

DGLUCY

396

Q7Z3D6
KQVVVPAGGSSTIYI

DLEC1

1391

Q9Y238
VGSYQEKVDVVLGPI

DMBT1

2386

Q9UGM3
GKIINTPEVVRVYIG

EHD1

241

Q9H4M9
GAYIGGTQIIPFVIK

CFAP47

1066

Q6ZTR5
EPTIGDIYNGKVTSI

DHX8

261

Q14562
GYPVLQSAISTIIGV

PTCHD3

896

Q3KNS1
IKGTVLIGVNFVGYS

NUP210L

861

Q5VU65
PIVYGVRTKEIKQGI

OR56A1

296

Q8NGH5
PVYLATVVGNGLIVL

OR4B1

31

Q8NGF8
TQKSLVYGLVGAGVV

MUC17

4386

Q685J3
KPQVAYKTEIIGGVV

PLEKHA2

141

Q9HB19
YKTEIIGGVVVHTPI

PLEKHA2

146

Q9HB19
APDIGLQYKGELTVV

SYTL5

536

Q8TDW5
QVGETSLYGVPIVSL

SKOR1

76

P84550
SLYGVPIVSLVIDGQ

SKOR1

81

P84550
TYKTVSGVNGPLVIL

ATP6V1B2

46

P21281
EKGASGVIIYNVPGT

RNF133

121

Q8WVZ7
LQTVGGYTGKVCIIP

SLFN14

496

P0C7P3
GVTIQPLKRDYGVQL

MRPL15

126

Q9P015
YVGETQPTGQIKIKR

SAMHD1

456

Q9Y3Z3
GTQKYVGPLKVTVQE

TAF2

556

Q6P1X5
TGKIVAPELYIAVGI

ETFA

266

P13804
TVKKVVYSLPRVGVG

NBEA

2246

Q8NFP9
LGSYVKQGTEIVPVG

PDIK1L

266

Q8N165
QVVGTPLLVKSGVEY

SEMA4A

401

Q9H3S1
IFGYKEIPVLVTQIS

PLXDC2

256

Q6UX71
KCPSYVGITGILLQE

POP4

146

O95707
NLVGIVVYTPVINGI

SLC41A2

406

Q96JW4
QTTGLIPANYVKILG

PEX13

321

Q92968
VYVGKIGLVISPLIS

WRN

586

Q14191
GYGVVLVKPTIFSDL

SHCBP1

541

Q8NEM2
GTIISGIQLLIVEYK

SLC35F2

236

Q8IXU6
GIYLTNILKTEEGNP

SOS1

931

Q07889
GKIVNTPEVIRVYIG

EHD3

241

Q9NZN3
TTRSIAKYPVGIEVG

ASPA

166

P45381
LSVEVNGYKILIPKG

TECTA

381

O75443
VITKGFTQLPGDAIY

TRAK2

591

O60296
VTLQPGEYITKVFVA

ZG16B

111

Q96DA0
ELLGTYIKQGTEIVP

STK35

461

Q8TDR2
YIKQGTEIVPVGEAL

STK35

466

Q8TDR2
GAVQQYIRTIGKLEP

VPS11

406

Q9H270
SVYKNVILQVPVGLT

PIGX

211

Q8TBF5
EKVKQVTPLSVGVYV

RPA4

111

Q13156
VTPLSVGVYVKVFGI

RPA4

116

Q13156
LTQLITGPKAVEAYG

SGCD

121

Q92629
IGSGIFVSPKGVLIY

SLC7A7

51

Q9UM01
QTGLKPGEEYIVNVV

TNR

471

Q92752
AQAATGYVIDPIKGL

PLEC

4106

Q15149
ELLKSIPVGVGQIYG

SLC14A1

221

Q13336
VIIKGTQVYSPEKGR

SNRNP200

826

O75643
QPIDVTVTLKLGGYE

PIEZO1

2206

Q92508
VKGVTIVKPIVYGNV

YEATS4

16

O95619
KKQVSYRTDIVGGVP

PLEKHA1

136

Q9HB21
PNVIVTYKGTLAEVR

SMYD2

211

Q9NRG4
KVTVIGAGITVYEAL

TKTL1

476

P51854
ITVIKLDGTTPVRYG

USP6

721

P35125
PVGKVLKVDGAYVAV

UBR5

666

O95071
VVVFVPGNIVGKYGT

TM6SF1

151

Q9BZW5
ARGNVIVPYKTIEGT

SLC8A1

566

P32418
FIGEVVVSVNPYKLL

MYO1D

41

O94832
VIQGIISPVNDTYGK

NMNAT3

41

Q96T66