Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	microfibril	MFAP4 FBN2 ADAMTSL5	3.30e-05	13	104	3	GO:0001527
Domain	Proteasome_bsu_C	PSMB7 PSMB10	2.95e-05	2	102	2	IPR024689
Domain	Pr_beta_C	PSMB7 PSMB10	2.95e-05	2	102	2	PF12465
Domain	VWD	MUC5B MUC4 MUC5AC	8.41e-05	16	102	3	SM00216
Domain	VWF_type-D	MUC5B MUC4 MUC5AC	8.41e-05	16	102	3	IPR001846
Domain	VWFD	MUC5B MUC4 MUC5AC	8.41e-05	16	102	3	PS51233
Domain	VWD	MUC5B MUC4 MUC5AC	8.41e-05	16	102	3	PF00094
Domain	NXF_fam	NXF5 NXF2	8.83e-05	3	102	2	IPR030217
Domain	Tap-RNA_bind	NXF5 NXF2	1.76e-04	4	102	2	PF09162
Domain	Tap_RNA_bd	NXF5 NXF2	1.76e-04	4	102	2	PD043466
Domain	Tap_RNA-bd	NXF5 NXF2	1.76e-04	4	102	2	IPR015245
Domain	-	CUBN CDCP1 ZZEF1 LRP3	1.86e-04	52	102	4	2.60.120.290
Domain	CUB_dom	CUBN CDCP1 ZZEF1 LRP3	2.65e-04	57	102	4	IPR000859
Domain	WxxW_domain	MUC5B MUC5AC	4.37e-04	6	102	2	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC5AC	4.37e-04	6	102	2	PF13330
Domain	NTF2_DOMAIN	NXF5 NXF2	1.04e-03	9	102	2	PS50177
Domain	NTF2	NXF5 NXF2	1.04e-03	9	102	2	IPR002075
Domain	Pept_T1A_subB	PSMB7 PSMB10	1.29e-03	10	102	2	IPR000243
Domain	Proteasome_suB-type	PSMB7 PSMB10	1.57e-03	11	102	2	IPR023333
Domain	PROTEASOME_BETA_1	PSMB7 PSMB10	1.57e-03	11	102	2	PS00854
Domain	PROTEASOME_BETA_2	PSMB7 PSMB10	1.57e-03	11	102	2	PS51476
Domain	PSI	ITGB8 SEMA6D SEMA5B	1.78e-03	44	102	3	IPR016201
Domain	TIL	MUC5B MUC5AC	1.88e-03	12	102	2	PF01826
Domain	Proteasome_bsu_CS	PSMB7 PSMB10	1.88e-03	12	102	2	IPR016050
Domain	C8	MUC5B MUC5AC	1.88e-03	12	102	2	PF08742
Domain	fn3	DSCAML1 TNN ROS1 MYBPHL USH2A	1.95e-03	162	102	5	PF00041
Domain	PSI	ITGB8 SEMA6D SEMA5B	2.02e-03	46	102	3	SM00423
Domain	-	NXF5 NXF2	2.22e-03	13	102	2	3.10.450.50
Domain	Unchr_dom_Cys-rich	MUC5B MUC5AC	2.22e-03	13	102	2	IPR014853
Domain	C8	MUC5B MUC5AC	2.22e-03	13	102	2	SM00832
Domain	-	IFT172 SEMA6D SEMA5B WDR20 WDR82 PLRG1 BRWD1	2.34e-03	333	102	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	IFT172 SEMA6D SEMA5B WDR20 WDR82 PLRG1 BRWD1	2.42e-03	335	102	7	IPR015943
Domain	TIL_dom	MUC5B MUC5AC	2.57e-03	14	102	2	IPR002919
Domain	EGF_1	CUBN ITGB8 FBN2 TNN USH2A MUC4	2.76e-03	255	102	6	PS00022
Domain	Glyco_hormone_CN	MUC5B MUC5AC	2.96e-03	15	102	2	IPR006208
Domain	NTF2-like_dom	NXF5 NXF2	2.96e-03	15	102	2	IPR032710
Domain	Cys_knot	MUC5B MUC5AC	2.96e-03	15	102	2	PF00007
Domain	CUB	CUBN CDCP1 LRP3	3.04e-03	53	102	3	PS01180
Domain	G-alpha	GNA14 GNAI2	3.37e-03	16	102	2	PF00503
Domain	GproteinA_insert	GNA14 GNAI2	3.37e-03	16	102	2	IPR011025
Domain	-	GNA14 GNAI2	3.37e-03	16	102	2	1.10.400.10
Domain	G_alpha	GNA14 GNAI2	3.37e-03	16	102	2	SM00275
Domain	FN3	DSCAML1 TNN ROS1 MYBPHL USH2A	3.47e-03	185	102	5	SM00060
Domain	C345C	ADAMTSL5 C5	3.81e-03	17	102	2	SM00643
Domain	Gprotein_alpha_su	GNA14 GNAI2	3.81e-03	17	102	2	IPR001019
Domain	Ig_I-set	FLT1 DSCAML1 FCRL1 ICAM5 MYBPHL	3.88e-03	190	102	5	IPR013098
Domain	I-set	FLT1 DSCAML1 FCRL1 ICAM5 MYBPHL	3.88e-03	190	102	5	PF07679
Domain	CTCK_1	MUC5B MUC5AC	4.27e-03	18	102	2	PS01185
Domain	FN3	DSCAML1 TNN ROS1 MYBPHL USH2A	4.72e-03	199	102	5	PS50853
Domain	VWC_out	MUC5B MUC5AC	4.75e-03	19	102	2	SM00215
Domain	Proteasome	PSMB7 PSMB10	4.75e-03	19	102	2	PF00227
Domain	NTR	ADAMTSL5 C5	4.75e-03	19	102	2	PF01759
Domain	PRAME_family	PRAMEF7 PRAMEF8	4.75e-03	19	102	2	IPR026271
Domain	Netrin_module_non-TIMP	ADAMTSL5 C5	4.75e-03	19	102	2	IPR018933
Domain	Proteasome_sua/b	PSMB7 PSMB10	4.75e-03	19	102	2	IPR001353
Domain	Semaphorin	SEMA6D SEMA5B	5.26e-03	20	102	2	IPR027231
Pathway	REACTOME_DISEASES_OF_METABOLISM	MUC5B CUBN ADAMTSL5 SEMA5B ACAN NUS1 PC PCCB MUC4 MUC5AC	7.75e-07	250	75	10	M27554
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	MUC5B ADAMTSL5 SEMA5B ACAN NUS1 MUC4 MUC5AC	1.06e-05	143	75	7	M27275
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	MUC5B ADAMTSL5 SEMA5B MUC4 MUC5AC	2.99e-05	68	75	5	M27303
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC5B MUC4 MUC5AC	7.71e-05	16	75	3	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC5B MUC4 MUC5AC	9.32e-05	17	75	3	M27412
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC5B MUC4 MUC5AC	1.80e-04	21	75	3	MM15706
Pathway	REACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM	CUBN PC PCCB	2.07e-04	22	75	3	M27243
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC5B MUC4 MUC5AC	2.37e-04	23	75	3	M556
Pathway	PID_S1P_S1P2_PATHWAY	FOS GNA14 GNAI2	2.70e-04	24	75	3	M268
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC5B ADAMTSL5 SEMA5B MUC4 MUC5AC	2.83e-04	109	75	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC5B ADAMTSL5 SEMA5B MUC4 MUC5AC	3.08e-04	111	75	5	M27416
Pathway	REACTOME_DECTIN_2_FAMILY	MUC5B MUC4 MUC5AC	3.44e-04	26	75	3	M27483
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	ITGB8 MFAP4 FBN2 ICAM5 ACAN TNN CAPN15	4.36e-04	258	75	7	MM14572
Pathway	PID_S1P_S1P3_PATHWAY	FLT1 GNA14 GNAI2	4.78e-04	29	75	3	M55
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	ITGB8 MFAP4 FBN2	6.42e-04	32	75	3	MM14854
Pubmed	Polymorphism of human mucin genes in chest disease: possible significance of MUC2.	MUC5B MUC4 MUC5AC	2.74e-07	5	106	3	11062147
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 TEX13A PRAMEF8 NXF5 NXF2	1.05e-06	59	106	5	11279525
Pubmed	Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).	MUC5B MUC5AC	9.20e-06	2	106	2	7513696
Pubmed	The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.	MUC5B MUC5AC	9.20e-06	2	106	2	37146737
Pubmed	MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.	MUC5B MUC5AC	9.20e-06	2	106	2	14988081
Pubmed	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.	MUC5B MUC5AC	9.20e-06	2	106	2	15563276
Pubmed	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.	MUC5B MUC5AC	9.20e-06	2	106	2	17621824
Pubmed	MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer.	MUC4 MUC5AC	9.20e-06	2	106	2	18475301
Pubmed	Muc5b is required for airway defence.	MUC5B MUC5AC	9.20e-06	2	106	2	24317696
Pubmed	Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.	MUC5B MUC5AC	9.20e-06	2	106	2	22391959
Pubmed	Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.	MUC5B MUC5AC	9.20e-06	2	106	2	35776514
Pubmed	The ocular surface phenotype of Muc5ac and Muc5b null mice.	MUC5B MUC5AC	9.20e-06	2	106	2	24327612
Pubmed	Molecular cloning of the mouse proteasome subunits MC14 and MECL-1: reciprocally regulated tissue expression of interferon-gamma-modulated proteasome subunits.	PSMB7 PSMB10	9.20e-06	2	106	2	9174609
Pubmed	Gel-forming mucins form distinct morphologic structures in airways.	MUC5B MUC5AC	9.20e-06	2	106	2	28607090
Pubmed	Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.	MUC5B MUC5AC	9.20e-06	2	106	2	31030254
Pubmed	The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.	MUC5B MUC5AC	9.20e-06	2	106	2	23527003
Pubmed	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.	MUC5B MUC5AC	9.20e-06	2	106	2	16540890
Pubmed	Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.	MUC5B MUC5AC	9.20e-06	2	106	2	27845589
Pubmed	Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.	MUC5B MUC5AC	9.20e-06	2	106	2	27435107
Pubmed	Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction.	FLT1 C5	9.20e-06	2	106	2	16923853
Pubmed	Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.	MUC5B MUC5AC	9.20e-06	2	106	2	26871672
Pubmed	Expression of mucins in mucoid otitis media.	MUC5B MUC4	9.20e-06	2	106	2	14690056
Pubmed	In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.	MUC5B MUC5AC	9.20e-06	2	106	2	11587997
Pubmed	Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice.	MUC4 MUC5AC	9.20e-06	2	106	2	19158956
Pubmed	Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.	MUC5B MUC5AC	9.20e-06	2	106	2	34656442
Pubmed	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	MUC5B MUC5AC	9.20e-06	2	106	2	34058148
Pubmed	C-Mannosylation of MUC5AC and MUC5B Cys subdomains.	MUC5B MUC5AC	9.20e-06	2	106	2	14718370
Pubmed	Mucin production during prenatal and postnatal murine lung development.	MUC5B MUC5AC	9.20e-06	2	106	2	21653907
Pubmed	MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.	MUC5B MUC5AC	9.20e-06	2	106	2	36427316
Pubmed	Mucin deficiency causes functional and structural changes of the ocular surface.	MUC5B MUC5AC	9.20e-06	2	106	2	23272068
Pubmed	Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.	MUC5B MUC5AC	9.20e-06	2	106	2	27729120
Pubmed	De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.	MUC5B MUC5AC	9.20e-06	2	106	2	36111525
Pubmed	Regional localization of the human c-ros-1 on 6q22 and flt on 13q12.	FLT1 ROS1	9.20e-06	2	106	2	3115921
Pubmed	Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.	MUC5B MUC5AC	9.20e-06	2	106	2	32348677
Pubmed	Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.	MUC5B MUC5AC	9.20e-06	2	106	2	24332705
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC5B MUC4 MUC5AC	2.17e-05	18	106	3	18834073
Pubmed	High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.	MUC5B MUC5AC	2.76e-05	3	106	2	29286856
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	MUC5B MUC5AC	2.76e-05	3	106	2	36675209
Pubmed	Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1.	FOS MAZ	2.76e-05	3	106	2	19028685
Pubmed	Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.	MUC5B MUC5AC	2.76e-05	3	106	2	29802623
Pubmed	Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.	MUC5B MUC5AC	2.76e-05	3	106	2	29604272
Pubmed	Aquaporin 5 expression increases mucin production in lung adenocarcinoma.	MUC5B MUC5AC	2.76e-05	3	106	2	21455588
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	MUC5B MUC5AC	2.76e-05	3	106	2	20422702
Pubmed	Dysregulation of complement system in HELLP syndrome.	FLT1 C5	2.76e-05	3	106	2	34697959
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC5B MUC5AC	2.76e-05	3	106	2	19718741
Pubmed	Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.	MUC5B MUC5AC	2.76e-05	3	106	2	27776277
Pubmed	Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.	MUC5B MUC5AC	2.76e-05	3	106	2	34158522
Pubmed	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.	MUC5B MUC5AC	2.76e-05	3	106	2	19596978
Pubmed	Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.	MUC5B MUC5AC	2.76e-05	3	106	2	19556605
Pubmed	Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas.	MUC4 MUC5AC	2.76e-05	3	106	2	23464473
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC5B MUC5AC	5.50e-05	4	106	2	25638393
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC5B MUC5AC	5.50e-05	4	106	2	22269464
Pubmed	SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory.	ICAM5 PHLPP1	5.50e-05	4	106	2	27686624
Pubmed	Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.	MUC5B MUC5AC	5.50e-05	4	106	2	18258655
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC5AC	5.50e-05	4	106	2	23807779
Pubmed	Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.	SMC1A BRAT1	5.50e-05	4	106	2	22977523
Pubmed	ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.	MUC5B MUC5AC	5.50e-05	4	106	2	31582416
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC5AC	5.50e-05	4	106	2	17471237
Pubmed	MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.	MUC5B MUC5AC	5.50e-05	4	106	2	21097527
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC5AC	5.50e-05	4	106	2	14984930
Pubmed	TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.	MUC5B MUC5AC	5.50e-05	4	106	2	23249391
Pubmed	Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.	PSMB7 PSMB10	5.50e-05	4	106	2	8666937
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC5AC	5.50e-05	4	106	2	29869461
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC5B MUC5AC	5.50e-05	4	106	2	12676567
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	MFAP4 FBN2	9.15e-05	5	106	2	26601954
Pubmed	Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells.	NXF5 NXF2	9.15e-05	5	106	2	17548835
Pubmed	NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.	NXF5 NXF2	9.15e-05	5	106	2	17403691
Pubmed	Differential expression of MUC genes in endometrial and cervical tissues and tumors.	MUC5B MUC5AC	9.15e-05	5	106	2	16188033
Pubmed	MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer.	MUC4 MUC5AC	9.15e-05	5	106	2	16475027
Pubmed	Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins.	NXF5 NXF2	9.15e-05	5	106	2	17978099
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	RLN1 FBN2	9.15e-05	5	106	2	12590922
Pubmed	The DNA sequence and analysis of human chromosome 6.	DXO UFL1 TNFRSF21 RAB44 ATF6B SYNJ2 NUS1 ROS1 HSD17B8	1.24e-04	622	106	9	14574404
Pubmed	HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.	USP16 PTOV1	1.37e-04	6	106	2	21090589
Pubmed	Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.	WDR20 PHLPP1	1.37e-04	6	106	2	25216524
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC5B MUC5AC	1.37e-04	6	106	2	19110483
Pubmed	Cloning and characterization of a novel regulator of G protein signalling in human platelets.	RGS18 GNAI2	1.37e-04	6	106	2	11955952
Pubmed	Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.	GNA14 GNAI2	1.37e-04	6	106	2	8982657
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF8 ACAN	1.68e-04	35	106	3	19389355
Pubmed	Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man.	FOS C5	1.91e-04	7	106	2	3186715
Pubmed	Net-targeted mutant mice develop a vascular phenotype and up-regulate egr-1.	FLT1 FOS	1.91e-04	7	106	2	11566878
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	NEPRO FBL SMC1A MAZ PRC1 NSUN2 PTOV1 PC BRAT1 PCCB PLRG1	2.21e-04	989	106	11	36424410
Pubmed	Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.	FOS FBN2 ACAN	2.50e-04	40	106	3	30578393
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN2 TNN	2.55e-04	8	106	2	23055981
Pubmed	The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.	WDR20 PHLPP1	2.55e-04	8	106	2	27463890
Pubmed	Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors.	MAZ PSMB7	2.55e-04	8	106	2	9986727
Pubmed	Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.	FBN2 ACAN	3.27e-04	9	106	2	15296947
Pubmed	The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.	PSMB7 PSMB10	3.27e-04	9	106	2	9300697
Pubmed	NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.	NXF5 NXF2	3.27e-04	9	106	2	11566096
Pubmed	Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach.	GNA14 GNAI2	4.08e-04	10	106	2	8588930
Pubmed	Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development.	FLT1 ITGB8	4.08e-04	10	106	2	31665628
Pubmed	Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation.	PSMB7 PSMB10	4.08e-04	10	106	2	11745344
Pubmed	Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.	PC PCCB	4.08e-04	10	106	2	18678647
Pubmed	Human transcription factor protein interaction networks.	NEPRO DET1 FOS SMC1A MAZ PSMB7 NSUN2 FHAD1 TIMM8A FBN2 WDR20 LSM14A PCCB	4.12e-04	1429	106	13	35140242
Pubmed	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.	FOS MUC5B C5 MUC4 MUC5AC	4.15e-04	204	106	5	20503287
Pubmed	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	FOS MUC5B C5 MUC4 MUC5AC	4.24e-04	205	106	5	19258923
Pubmed	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	FOS MUC5B C5 MUC4 MUC5AC	4.43e-04	207	106	5	17703412
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	FBL SMC1A UFL1 SCAMP3 NSUN2 PC	4.80e-04	323	106	6	24797263
Pubmed	Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.	MUC5B MUC5AC	4.97e-04	11	106	2	24429156
Pubmed	Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.	NXF5 NXF2	4.97e-04	11	106	2	16014633
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FBL SMC1A NSUN2 MYL9 BRCA2 JRK ROS1 GNAI2 PLRG1	5.10e-04	754	106	9	35906200
GeneFamily	CD molecules\|Mucins	MUC5B MUC4 MUC5AC	8.30e-05	21	74	3	648
GeneFamily	Fibronectin type III domain containing	DSCAML1 TNN ROS1 MYBPHL USH2A	5.02e-04	160	74	5	555
GeneFamily	Immunoglobulin like domain containing	FLT1 CCDC141 DSCAML1 FCRL1 ICAM5	1.17e-03	193	74	5	594
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6D SEMA5B	2.99e-03	20	74	2	736
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	TEX13A CAPN15	3.30e-03	21	74	2	89
GeneFamily	PRAME family	PRAMEF7 PRAMEF8	4.30e-03	24	74	2	686
GeneFamily	WD repeat domain containing	IFT172 WDR20 WDR82 PLRG1 BRWD1	4.39e-03	262	74	5	362
GeneFamily	Fibrinogen C domain containing	MFAP4 TNN	4.66e-03	25	74	2	554
Coexpression	NABA_ECM_AFFILIATED	MUC5B SEMA6D SEMA5B CLEC11A CLEC2D MUC4 MUC5AC	3.74e-06	158	106	7	MM17063
Coexpression	NABA_ECM_AFFILIATED	MUC5B SEMA6D SEMA5B CLEC11A CLEC2D MUC4 MUC5AC	6.06e-06	170	106	7	M5880
Coexpression	GSE37416_CTRL_VS_24H_F_TULARENSIS_LVS_NEUTROPHIL_UP	PDK4 PARG TIMM8A JRK NAA20 HELZ2 GAB3	1.53e-05	196	106	7	M5337
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TNFRSF21 FHAD1 FBN2 SEMA6D SYNJ2 CLEC11A ACAN	5.19e-07	200	106	7	4e1e19214aeebbdca004de7faaf4cc9d18498591
Disease	mucinous adenocarcinoma (is_marker_for)	MUC4 MUC5AC	1.11e-04	5	99	2	DOID:3030 (is_marker_for)
Disease	biliary tract benign neoplasm (is_marker_for)	MUC4 MUC5AC	2.31e-04	7	99	2	DOID:0050625 (is_marker_for)
Disease	Malignant neoplasm of breast	FLT1 FBL FOS CUBN PRC1 BRCA2 SEMA5B SYNJ2 ICAM5 GNAI2 HSD17B8 NLRP8	2.55e-04	1074	99	12	C0006142
Disease	common bile duct neoplasm (is_marker_for)	MUC4 MUC5AC	3.08e-04	8	99	2	DOID:4608 (is_marker_for)
Disease	chronic obstructive pulmonary disease (is_marker_for)	FLT1 MUC5B C5 MUC5AC	3.25e-04	97	99	4	DOID:3083 (is_marker_for)
Disease	obsessive-compulsive disorder	SLC6A15 SEMA6D TNN LSM14A	3.65e-04	100	99	4	EFO_0004242
Disease	Mammary Carcinoma, Human	FLT1 FBL FOS PRC1 BRCA2 SYNJ2 ICAM5 GNAI2	3.96e-04	525	99	8	C4704874
Disease	Mammary Neoplasms, Human	FLT1 FBL FOS PRC1 BRCA2 SYNJ2 ICAM5 GNAI2	3.96e-04	525	99	8	C1257931
Disease	Mammary Neoplasms	FLT1 FBL FOS PRC1 BRCA2 SYNJ2 ICAM5 GNAI2	4.06e-04	527	99	8	C1458155
Disease	Breast Carcinoma	FLT1 FBL FOS PRC1 BRCA2 SYNJ2 ICAM5 GNAI2	4.65e-04	538	99	8	C0678222
Disease	otitis media (is_marker_for)	MUC5B MUC4	4.93e-04	10	99	2	DOID:10754 (is_marker_for)
Disease	response to statin, myopathy	CDCP1 FBN2	6.01e-04	11	99	2	EFO_0004145, GO_0036273
Disease	pulmonary fibrosis	MUC5B MUC5AC	6.01e-04	11	99	2	EFO_0009448
Disease	fructose measurement, glucose measurement, galactose measurement	TNFRSF21 DSCAML1	7.20e-04	12	99	2	EFO_0004468, EFO_0010477, EFO_0010481
Disease	kynurenic acid measurement	ZNF177 SEMA6D	8.48e-04	13	99	2	EFO_0010506
Disease	Down syndrome (implicated_via_orthology)	DSCAML1 SYNJ2	1.14e-03	15	99	2	DOID:14250 (implicated_via_orthology)
Disease	pancreatic ductal carcinoma (is_marker_for)	MUC5B MUC4 MUC5AC	1.14e-03	61	99	3	DOID:3587 (is_marker_for)
Disease	Liver Cirrhosis, Experimental	FOS DOCK10 PSMB10 MFAP4 GNA14 SEMA6D MYL9 GNAI2 PC	1.19e-03	774	99	9	C0023893
Disease	cystic fibrosis (is_marker_for)	MUC5B C5 MUC5AC	1.20e-03	62	99	3	DOID:1485 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	MUC5B MUC4 MUC5AC	1.32e-03	64	99	3	DOID:4947 (is_marker_for)
Disease	otitis media (biomarker_via_orthology)	MUC4 MUC5AC	1.47e-03	17	99	2	DOID:10754 (biomarker_via_orthology)
Disease	melanoma	FLT1 CUBN BRCA2 NUS1 ROS1	1.52e-03	248	99	5	C0025202
Disease	borna disease (biomarker_via_orthology)	PARG ALDOC	1.65e-03	18	99	2	DOID:5154 (biomarker_via_orthology)
Disease	anorectal malformation	MUC5B NLRP8	1.84e-03	19	99	2	MONDO_0019938
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	KCNMA1 BRWD1	2.24e-03	21	99	2	EFO_0004616, EFO_0010726, EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLRLAGTFAAQENCF	BRAT1	76	Q6PJG6
SEEEASFNLNAINRC	ALDOC	276	P09972
SFFSAFCTEDNIEQS	SSX2IP	51	Q9Y2D8
RASVSFLNFNLSNCE	CDCP1	261	Q9H5V8
DQNVFTAFTCLSADC	FERMT1	626	Q9BQL6
CTDVSADFAQAAIFA	AP4B1	356	Q9Y6B7
ENFCDLFRNATLHSE	DET1	391	Q7L5Y6
CGNFDDNAINDFATR	MUC5B	1026	Q9HC84
RFCEASAKDNFNVDE	RAB12	181	Q6IQ22
FEAQECERINFFRNA	PSTPIP2	216	Q9H939
KTFSFNFCRENIIDD	OR9G1	161	Q8NH87
SSQAAAELQAFFQDC	RAB44	41	Q7Z6P3
FDNCRRNAVLEADFA	PSMB7	16	Q99436
NNSGEEFDCAFRLAQ	NSUN2	591	Q08J23
ENACERTSFAFLRQE	PDK4	46	Q16654
NIVAFCRENNVSFVD	CAPN15	476	O75808
SNAEDANFTLRDSCT	MUC4	4976	Q99102
DNFFTICNNFDATES	LINS1	536	Q8NG48
VNDCSTSFRAFEDEQ	KCNMA1	746	Q12791
AQDFCTDLAVSSANF	FOS	46	P01100
GFLNEACASAVEQSF	NLRP8	561	Q86W28
RSLEQASFDDVFVDC	GAB3	211	Q8WWW8
DVIRNAFACFDEEAS	MYL9	101	P24844
AFTCDDLFRFNNINL	NAA20	6	P61599
FACAFDQSESRLLTA	PLRG1	466	O43660
NATENDDRRSFFCDA	ICAM5	371	Q9UMF0
AAEQFCAFFRSLAAE	JRK	161	O75564
NRACFFVQVASAASA	NXF5	51	Q9H1B4
DQREIAHAACFTQSF	OR51B4	86	Q9Y5P0
SQEQIASLLANAFFC	PARG	626	Q86W56
DFFSALRQYAACEQR	NUS1	276	Q96E22
ANCIDSTASAEAVFA	FBL	266	P22087
ISFRNFDVEESHQCS	LRP3	86	O75074
AELQSRFFASQGCAQ	MAZ	46	P56270
EFSCNSFLQEKAAAA	HOXD9	206	P28356
TKSFFDNISCDDNRE	LSM14A	366	Q8ND56
ASAQESFAVSNRELC	MSANTD3	136	Q96H12
CGNFNSIQADDFRTL	MUC5AC	571	P98088
CGNFDDIAVNDFATR	MUC5AC	1036	P98088
APEISSNACFAQEFF	OR51A4	91	Q8NGJ6
ANDSCLFVQRVFRDA	ADAMTSL5	196	Q6ZMM2
CAAFLSFAQSTVVQD	DXO	331	O77932
FQEALEFCESHNATL	ACAN	591	P16112
ADNCSFEFAFELSRL	IFT172	1121	Q9UG01
QLAQFHFTNRDCDSL	PTOV1	161	Q86YD1
FENDVDALCNLRDFF	PCCB	261	P05166
LAFFTAAFVCLQNDR	ITGB8	6	P26012
ISFQLEDSQDCSRDF	CUBN	1781	O60494
ENSVNFCFDSAFLTV	CEFIP	181	Q711Q0
EAECSFVLQDFNSRN	FHAD1	46	B1AJZ9
FFLQSNRLQSCAEID	KLHL26	211	Q53HC5
AFADACNDKRETFSS	CCDC141	1271	Q6ZP82
SDFFSILDVCLQNFR	DOCK10	1366	Q96BY6
FRQFADACGQALDVN	DOCK10	2101	Q96BY6
SELINCSAQFEANAF	BRCA2	611	P51587
CSAQFEANAFEAPLT	BRCA2	616	P51587
FSFTAAAADRQCVKA	DNAH3	536	Q8TD57
CFATRKAQTAQDFAI	DSCAML1	386	Q8TD84
SDAQFQFCFFRDTRA	FCRL1	46	Q96LA6
AFQADVSEARAARCL	HSD17B8	71	Q92506
SCQAFLANLDEFAED	C5	1656	P01031
VDSIQFCNNGDRFLS	BRWD1	371	Q9NSI6
AFRVFAENQCGLSET	MYBPHL	216	A2RUH7
SFVNDVFEQLACEAA	H2BK1	61	A0A2R8Y619
CFDTRQSFCFTNFEN	FBN2	2096	P35556
AAFLEENCADINFSC	HELZ2	1991	Q9BYK8
RNVDENFCDIFSGAT	PRAMEF8	106	Q5VWM4
NFLACLASFCVETNN	SCAMP3	181	O14828
CDFNLFLEDSADNRQ	ERCC6L	951	Q2NKX8
RNRACFFVQDASAAS	NXF2	161	Q9GZY0
SVQVDTFRANLFCTD	KCTD11	116	Q693B1
CATDTDNIRFVFAAV	GNA14	326	O95837
FCAAAAASTAINAQR	RPUSD4	31	Q96CM3
AAAESIQFCTQRFCI	USH2A	71	O75445
RDNNCHFDAVLVSFI	SLC6A15	326	Q9H2J7
FLCNASEREVAAFSN	TNFRSF21	436	O75509
TANSCLLEENFDFTS	SYNJ2	991	O15056
EFCLLLNQFSRAVAA	RLN1	11	P04808
ADDARQLFALSCTAE	GNAI2	101	P04899
ESSEFDVRAFCNQLK	NEPRO	306	Q6NW34
STFDRDQDLFVQNCA	MFAP4	186	P55083
SQEQRQAFAPFCAED	PRC1	311	O43663
QIFTEANFSRECFSL	SHOC1	126	Q5VXU9
ANFSRECFSLQETLE	SHOC1	131	Q5VXU9
ACVSQDGFLRVFNFD	WDR20	236	Q8TBZ3
GFSFENCQRNASLER	PSMB10	11	P40306
ANLSEALCAANVDFS	PLAGL2	401	Q9UPG8
DLDQLFLSSDCRHFN	ATF6B	491	Q99941
SRDFEAQAAAQARCT	CLEC11A	191	Q9Y240
RFCDSQDADLAQVES	CLEC2D	101	Q9UHP7
RNVDENFCDIFSGAT	PRAMEF7	106	Q5VXH5
ELANSAQIESFLCFS	nan	76	Q96MF0
VALANQCLSQADAFF	VPS35L	731	Q7Z3J2
LEFTDCRKAFNQESS	ZNF177	176	Q13360
AFCTLANREVFNTDE	USP16	616	Q9Y5T5
VFRENSDKINCFDFS	WDR82	16	Q6UXN9
SRSFTCNEFQDVQSD	RGS18	216	Q9NS28
TTFDRDNDIALSNCA	TNN	1211	Q9UQP3
RFDRFNACFESVATN	SMC1A	1066	Q14683
FADVKSFACENNDFL	ROS1	496	P08922
AVCAFNLSAISQAFN	SEMA5B	386	Q9P283
ASCECQEIRNSFFQS	ZNF333	336	Q96JL9
NAVNFSRRDTCFDCG	TEX13A	386	Q9BXU3
CSSEQFEEAFAQFDA	ZZEF1	111	O43149
AALSVNNFCDNREAL	PHLPP1	1191	O60346
DFCSNNEESFILDAD	FLT1	481	P17948
CPFDARQTNVALFAD	SEMA6D	166	Q8NFY4
LSERADFAQACQDAG	PC	121	P11498
ACFVNCVERFIDTSQ	TIMM8A	61	O60220
FSCSLDNENRQTDQF	ZFYVE9	181	O95405
LAADFQRAQFAEATQ	UFL1	11	O94874
AGSQERVCFQDNRSF	KIAA1958	66	Q8N8K9