Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessdermatan sulfate metabolic process

HEXA HEXB DSE

7.39e-0610833GO:0030205
GeneOntologyBiologicalProcessdermatan sulfate proteoglycan metabolic process

HEXA HEXB DSE

1.75e-0513833GO:0050655
GeneOntologyCellularComponentbeta-N-acetylhexosaminidase complex

HEXA HEXB

1.60e-052842GO:1905379
MousePhenopremature sphenooccipital synchondrosis closure

PKD1 FGFR3

2.20e-052662MP:0030446
DomainBeta_hexosaminidase_sua/sub

HEXA HEXB

2.00e-052842IPR025705
DomainGlycohydro_20b2

HEXA HEXB

2.00e-052842PF14845
DomainHEX_eukaryotic_N

HEXA HEXB

2.00e-052842IPR029019
Domain-

HEXA HEXB

2.00e-0528423.30.379.10
DomainChitobiase/Hex_dom_2-like

HEXA HEXB

2.00e-052842IPR029018
DomainWD40

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

2.16e-05259848PF00400
DomainWD40

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

2.75e-05268848SM00320
DomainWD40_repeat

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

3.06e-05272848IPR001680
DomainWD_REPEATS_1

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

3.57e-05278848PS00678
DomainWD_REPEATS_2

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

3.66e-05279848PS50082
DomainWD_REPEATS_REGION

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

3.66e-05279848PS50294
DomainWD40_repeat_dom

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

5.69e-05297848IPR017986
DomainGlyco_hydro_20

HEXA HEXB

5.98e-053842PF00728
DomainGlyco_hydro_20_cat

HEXA HEXB

5.98e-053842IPR015883
Domain-

BAG5 BAG3

1.19e-0448421.20.58.120
Domain-

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

1.26e-043338482.130.10.10
DomainWD40/YVTN_repeat-like_dom

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

1.31e-04335848IPR015943
DomainBAG

BAG5 BAG3

1.98e-045842PS51035
DomainBAG_domain

BAG5 BAG3

1.98e-045842IPR003103
DomainBAG

BAG5 BAG3

1.98e-045842SM00264
DomainBAG

BAG5 BAG3

1.98e-045842PF02179
DomainGPS

CELSR1 PKD1 ADGRG6

4.75e-0434843SM00303
DomainGPS

CELSR1 PKD1 ADGRG6

5.18e-0435843PF01825
DomainGPS

CELSR1 PKD1 ADGRG6

5.63e-0436843PS50221
DomainGPS

CELSR1 PKD1 ADGRG6

6.11e-0437843IPR000203
DomainWD40_repeat_CS

EED WDHD1 RBBP4 TBL1X DCAF12

8.67e-04164845IPR019775
DomainWW

BAG3 ARHGAP27 WAC

1.23e-0347843PF00397
DomainWW

BAG3 ARHGAP27 WAC

1.31e-0348843SM00456
DomainWW_DOMAIN_2

BAG3 ARHGAP27 WAC

1.56e-0351843PS50020
DomainWW_DOMAIN_1

BAG3 ARHGAP27 WAC

1.56e-0351843PS01159
DomainWW_dom

BAG3 ARHGAP27 WAC

1.65e-0352843IPR001202
DomainQuinoprotein_ADH-like_supfam

WDR6 ARHGAP27 TBL1X

1.75e-0353843IPR011047
DomainEF-hand_1

SLC25A13 CAPSL DGKB FKBP14

4.91e-03152844PF00036
DomainEFh

SLC25A13 CAPSL DGKB FKBP14

5.63e-03158844SM00054
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

HEXB FLT3 BAG3 KLHL8 RSC1A1 SESN1 FGGY CARD8

1.04e-0631385820800603
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MBTPS1 TNRC18 EGFR RBBP4 TBK1 TRPM2 PRKCZ LRBA ERBIN TET3 SESN1 FGGY SFMBT2 TBL1X ADGRG6

2.97e-061489851528611215
Pubmed

Activity of lysosomal exoglycosidases in human gliomas.

HEXA HEXB

5.90e-06285216710745
Pubmed

Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

HEXA HEXB

5.90e-0628523013851
Pubmed

Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.

HEXA HEXB

5.90e-0628526458607
Pubmed

Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases.

HEXA HEXB

5.90e-0628528789434
Pubmed

Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits.

HEXA HEXB

5.90e-0628522965147
Pubmed

The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis.

HEXA HEXB

5.90e-0628521825792
Pubmed

Plasma and peripheral leukocyte beta-N-acetylhexosaminidase isoenzymes and disease activity in rheumatoid arthritis.

HEXA HEXB

5.90e-06285212413610
Pubmed

A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease.

HEXA HEXB

5.90e-0628529694901
Pubmed

GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.

HEXA HEXB

5.90e-06285222789865
Pubmed

Biochemical consequences of mutations causing the GM2 gangliosidoses.

HEXA HEXB

5.90e-06285210571007
Pubmed

Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism.

HEXA HEXB

5.90e-0628527550345
Pubmed

Neural precursor cell cultures from GM2 gangliosidosis animal models recapitulate the biochemical and molecular hallmarks of the brain pathology.

HEXA HEXB

5.90e-06285219166507
Pubmed

Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay-Sachs Disease and Sandhoff Disease Mouse Models.

HEXA HEXB

5.90e-06285234201771
Pubmed

Novel bicistronic lentiviral vectors correct β-Hexosaminidase deficiency in neural and hematopoietic stem cells and progeny: implications for in vivo and ex vivo gene therapy of GM2 gangliosidosis.

HEXA HEXB

5.90e-06285231682993
Pubmed

Three novel mutations in Iranian patients with Tay-Sachs disease.

HEXA HEXB

5.90e-06285224518553
Pubmed

Down-regulation of β-N-acetyl-D-glucosaminidase increases Akt1 activity in thyroid anaplastic cancer cells.

HEXA HEXB

5.90e-06285221637923
Pubmed

Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases.

HEXA HEXB

5.90e-0628529302266
Pubmed

Knock-down of HEXA and HEXB genes correlate with the absence of the immunostimulatory function of HSC-derived dendritic cells.

HEXA HEXB

5.90e-06285221997228
Pubmed

Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis.

HEXA HEXB

5.90e-0628528896570
Pubmed

Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.

HEXA HEXB

5.90e-0628526230359
Pubmed

Activation by tyrosine phosphorylation as a prerequisite for protein kinase Cζ to mediate epidermal growth factor receptor signaling to ERK.

EGFR PRKCZ

5.90e-06285220407013
Pubmed

Classification of disorders of GM2 ganglioside hydrolysis using 3H-GM2 as substrate.

HEXA HEXB

5.90e-0628528123671
Pubmed

Genetic expression of hexokinase and glucose phosphate isomerase in late-stage mouse preimplantation embryos: transcription activities in glucose/phosphate-containing HTF and glucose/phosphate-free P1 media.

HEXA HEXB

5.90e-0628529237263
Pubmed

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.

EGFR FGFR3

5.90e-06285223744832
Pubmed

Different expression of beta-N-acetylhexosaminidase in mouse tissues.

HEXA HEXB

5.90e-0628528147878
Pubmed

Identification of domains in human beta-hexosaminidase that determine substrate specificity.

HEXA HEXB

5.90e-0628528663217
Pubmed

FGFR3 phosphorylates EGFR to promote cisplatin-resistance in ovarian cancer.

EGFR FGFR3

5.90e-06285233794187
Pubmed

Pediatric reference data on activity of urinary N-acetyl-β-D-hexosaminidase and its isoenzymes.

HEXA HEXB

5.90e-06285228846871
Pubmed

I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency.

HEXA HEXB

5.90e-06285210591618
Pubmed

Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2.

HEXA HEXB

5.90e-0628529417048
Pubmed

Physiological substrates for human lysosomal beta -hexosaminidase S.

HEXA HEXB

5.90e-06285211707436
Pubmed

Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.

HEXA HEXB

5.90e-0628528634145
Pubmed

Direct determination of the substrate specificity of the alpha-active site in heterodimeric beta-hexosaminidase A.

HEXA HEXB

5.90e-0628528672428
Pubmed

[Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis].

HEXA HEXB

5.90e-06285223370522
Pubmed

Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.

HEXA HEXB

5.90e-0628528673609
Pubmed

Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts.

HEXA HEXB

5.90e-06285215953731
Pubmed

Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase.

HEXA HEXB

5.90e-0628522971395
Pubmed

Mice deficient in all forms of lysosomal beta-hexosaminidase show mucopolysaccharidosis-like pathology.

HEXA HEXB

5.90e-0628529184660
Pubmed

Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.

HEXA HEXB

5.90e-06285216698036
Pubmed

Accumulated α-synuclein affects the progression of GM2 gangliosidoses.

HEXA HEXB

5.90e-06285227453479
Pubmed

Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.

HEXA HEXB

5.90e-0628527959736
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

HEXA HEXB MBTPS1 CELSR1 EGFR MAT2B RBBP4 PAM BOLA2 ITGA7 DSE FKBP14 DCAF12

6.85e-061201851335696571
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

SLC25A13 BAG5 PKD1 PAM CEP126 KLHL8 PKHD1L1 ERBIN TET3 DSE

6.91e-06686851029987050
Pubmed

Glycosphingolipid degradation and animal models of GM2-gangliosidoses.

HEXA HEXB

1.77e-0538529728335
Pubmed

Tay-Sachs' and Sandhoff's diseases: the assignment of genes for hexosaminidase A and B to individual human chromosomes.

HEXA HEXB

1.77e-0538521054503
Pubmed

Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides.

HEXA HEXB

1.77e-0538529645704
Pubmed

Hyaluronidase 1 and β-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation.

HEXA HEXB

1.77e-05385222451654
Pubmed

Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR.

EGFR ERBIN

1.77e-05385225521828
Pubmed

MAT2B promotes proliferation and inhibits apoptosis in osteosarcoma by targeting epidermal growth factor receptor and proliferating cell nuclear antigen.

EGFR MAT2B

1.77e-05385230942439
Pubmed

Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment.

HEXA HEXB

1.77e-0538529223328
Pubmed

Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families.

ZNF543 CARD8

1.77e-05385226095808
Pubmed

HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.

EGFR PKD1

1.77e-05385223152903
Pubmed

A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder.

HEXA HEXB

1.77e-05385210021458
Pubmed

Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease.

GRAP2 PKD1 FGFR3

3.12e-052585321518438
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

DNHD1 EGFR WDR6 BAG5 BAG3 FGFR3 DYRK4

3.13e-0536385725036637
Pubmed

Chemical mutagenesis of a GPCR ligand: Detoxifying "inflammo-attraction" to direct therapeutic stem cell migration.

HEXA HEXB

3.53e-05485233219123
Pubmed

The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta.

GRB14 PRKCZ

3.53e-05485212242277
Pubmed

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

EED RBBP4

3.53e-05485215385962
Pubmed

Glomerular and tubular damage markers are elevated in patients with diabetes.

HEXA HEXB

3.53e-05485221307379
Pubmed

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

TREH FGFR3

3.53e-05485227701424
Pubmed

Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population.

FLT3 EGFR

3.53e-05485224005813
Pubmed

Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397.

ZNF24 ZNF396

3.53e-05485212801647
Pubmed

Vascular endothelial growth factor gene polymorphism is associated with calcium oxalate stone disease.

EGFR CYP17A1

3.53e-05485212719950
Pubmed

Analysis of the HEXA, HEXB, ARSA, and SMPD1 Genes in 68 Iranian Patients.

HEXA HEXB

3.53e-05485234554397
Pubmed

Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA.

EED RBBP4

5.87e-05585225601759
Pubmed

TUCAN (CARD8) genetic variants and inflammatory bowel disease.

TNFSF15 CARD8

5.87e-05585217030188
Pubmed

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

EED RBBP4

5.87e-05585215225548
Pubmed

Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.

FLT3 EGFR

5.87e-05585215020428
Pubmed

EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients.

EGFR CYP17A1

5.87e-05585221300759
Pubmed

Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.

HEXA HEXB

5.87e-05585218217416
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

WDR6 TBK1 BAG3 BOLA2 LRBA SFMBT2 TBL1X

7.60e-0541885734709266
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

HEXB EGFR WDR6 DZIP1 LRBA ITGA7 ERBIN

7.94e-0542185736976175
Pubmed

Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma.

EGFR FGFR3

8.80e-05685219812598
Pubmed

Cloning and characterization of GRB14, a novel member of the GRB7 gene family.

EGFR GRB14

8.80e-0568528647858
Pubmed

Kidney sulfatides in mouse models of inherited glycosphingolipid disorders: determination by nano-electrospray ionization tandem mass spectrometry.

HEXA HEXB

8.80e-05685211919180
Pubmed

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.

EGFR GRAP2

8.80e-05685210913131
Pubmed

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.

EED RBBP4

8.80e-05685221123648
Pubmed

Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.

HEXA HEXB

8.80e-05685216982810
Pubmed

Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development.

VWF ITGA7

8.80e-0568529686317
Pubmed

Role of histone H3 lysine 27 methylation in Polycomb-group silencing.

EED RBBP4

8.80e-05685212351676
Pubmed

Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.

EGFR FGFR3

8.80e-05685218231572
Pubmed

The DNA sequence of human chromosome 7.

RELN TNRC18 RARRES2 EGFR OSBPL3 SLC25A13 DGKB

1.06e-0444185712853948
Pubmed

HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.

HEXA HEXB

1.23e-04785227105913
Pubmed

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.

BAG5 BAG3

1.23e-0478529873016
Pubmed

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.

HEXA HEXB

1.23e-04785228728022
Pubmed

Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.

EGFR PKD1

1.23e-04785212095915
Pubmed

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis.

PKD1 PRKCZ

1.23e-04785224153433
Pubmed

Noncanonical imprinting sustains embryonic development and restrains placental overgrowth.

EED SFMBT2

1.23e-04785235483741
Pubmed

Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system.

VWF ITGA7

1.23e-0478528950511
Pubmed

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

EED RBBP4

1.23e-04785212435631
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

FLT3 EGFR FGFR3

1.30e-044085330898150
Pubmed

Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.

EGFR FGFR3

1.64e-0488527657660
Pubmed

Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations.

RELN EGFR

1.64e-04885222376909
Pubmed

Substrate preferences of the EZH2 histone methyltransferase complex.

EED RBBP4

1.64e-04885216431907
Pubmed

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.

EED RBBP4

1.64e-04885220144788
Pubmed

Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.

TBK1 ATG9A

1.64e-04885232556086
Pubmed

Expression of testicular germ cell genes identified by differential display analysis.

ANKRD20A4P ANKRD20A1

1.64e-04885212634303
Pubmed

Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.

EGFR CYP17A1

1.64e-04885218593984
InteractionANKRD20A1 interactions

ANKRD20A4P EGFR ANKRD20A1

1.17e-0511853int:ANKRD20A1
InteractionIL5RA interactions

MBTPS1 EGFR PAM FGFR3 ITGA7 FKBP14

1.41e-05124856int:IL5RA
InteractionACACB interactions

EED EGFR RBBP4 DPPA4 BAG5 DCAF12

1.93e-05131856int:ACACB
Cytoband18q12

ZNF24 ZNF396

2.61e-041385218q12
Cytoband13q12

FLT3 SACS

9.11e-042485213q12
CytobandEnsembl 112 genes in cytogenetic band chr18q12

ZNF24 ELP2 ZNF396

9.75e-04104853chr18q12
GeneFamilyWD repeat domain containing

EED WDHD1 RBBP4 WDR6 ELP2 LRBA TBL1X DCAF12

1.79e-06262588362
GeneFamilyBCL2 associated athanogene family

BAG5 BAG3

1.50e-0465821139
GeneFamilyLysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2

EED RBBP4

1.50e-0465821347
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CELSR1 MFSD4A PRKCZ PKHD1L1 SFMBT2

1.01e-061738569dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Gpr149_Islr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FLT3 TREH SLC25A13 BAG3 SFMBT2

1.35e-05159855c64fff8d89f84d1f5a0cc432e31f56f741162505
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1 PTPN20

1.44e-05161855133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1 PTPN20

1.44e-051618559466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCelldroplet-Thymus-nan-21m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 VWF CD244 TRPM2 ATP2A1

1.44e-05161855441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1 PTPN20

1.44e-05161855cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCelldroplet-Mammary_Gland-nan-18m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXA FLT3 CD244 TRPM2 ATP2A1

1.48e-0516285559147406c28b7cdf43a1815f99c15c2bd6ae8fa3
ToppCelldroplet-Mammary_Gland-nan-18m-Myeloid|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXA FLT3 CD244 TRPM2 ATP2A1

1.48e-051628558e0bcc23c3086fc4b0c9dbeec13a7edaf6b83750
ToppCelldroplet-Mammary_Gland-nan-18m-Myeloid-macrophage|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXA FLT3 CD244 TRPM2 ATP2A1

1.48e-05162855736fdcbd0f7d50fc297f13d36ab4c0dc82ad509c
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1 PTPN20

1.48e-0516285596c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCelldroplet-Spleen-nan-18m-Myeloid-macrophage|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 VWF CD244 TRPM2 ADGRG6

1.92e-051718554a2e6ea9674bf23e8012ef0bb2bf19ce1f55fcd5
ToppCellfacs-Heart-RV-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN SACS RHBG CAPSL PRKCZ

1.97e-05172855a26a73c41e5a05c9dd47a99f3320295f684c5e54
ToppCelldroplet-Spleen-nan-18m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 VWF CD244 TRPM2 ADGRG6

1.97e-05172855850e4c9e9003807c19695be4b13121b0808a9389
ToppCelldroplet-Spleen-nan-18m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 VWF CD244 TRPM2 ADGRG6

1.97e-05172855018d8160cfcb7882475620dc678f48a69a0f643e
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

ENAM RARRES2 TRPM2 GRB14 MMP26

2.09e-051748557e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCellBronchial_Biopsy-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ENAM RARRES2 TRPM2 GRB14 MMP26

2.14e-0517585513b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GRAP2 DZIP1 DYRK4 ITGA7 PKHD1L1

2.20e-05176855218a072882d387adbbad6916d7214099c7354465
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic-T_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELSR1 GBP6 OSBPL3 GRAP2 PRKCZ

2.26e-05177855baf78a8dad55f124f56585f88b10b58c0269680f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EGFR SACS RHBG DGKB TBL1X

2.33e-0517885551d2188406f04329311b2efd1108fc36617a860e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EGFR SACS RHBG DGKB TBL1X

2.45e-05180855cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TDRD7 CELSR1 SPATA6L GRB14 PRKCZ

2.66e-05183855c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN CYP4X1 ZNF543 PKHD1L1 PTPN20

2.73e-0518485530ca56d64c961127e26122613e35aa2b46fde2df
ToppCellLPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAP2 ATG9A RSC1A1 PKHD1L1 DCAF12

2.87e-05186855e5014443e9d6e25943308483e20d48b776ae5373
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELSR1 EGFR OSBPL3 PRKCZ ADGRG6

2.87e-051868554e94158db52df41d71e67b02b9895a358eebee0f
ToppCellLPS_only-Hematopoietic_Meg-Ery-Erythroid|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAP2 ATG9A RSC1A1 PKHD1L1 DCAF12

2.87e-05186855affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCellLPS_only-Hematopoietic_Meg-Ery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAP2 ATG9A RSC1A1 PKHD1L1 DCAF12

2.87e-0518685540d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RELN GRAP2 PKHD1L1 ANKRD20A1 DCAF12

2.87e-051868556078aa16261554c7fd41137b8de1362d15b30490
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRB14 FGFR3 PRKCZ LRBA TNFSF15

3.18e-051908558aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CELSR1 MFSD4A PRKCZ PKHD1L1

3.18e-05190855a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CELSR1 MFSD4A PRKCZ PKHD1L1

3.18e-051908550bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCellfacs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN CELSR1 MFSD4A PRKCZ PKHD1L1

3.18e-0519085526e2237f65cb43723c5da853831b40df2982d6e4
ToppCellfacs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CELSR1 MFSD4A PRKCZ PKHD1L1

3.26e-0519185548823a97c38263f2c6e58348214f5b62773a6368
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CELSR1 MFSD4A PRKCZ PKHD1L1

3.26e-051918550eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RELN RARRES2 CYP4X1 PRKCZ PKHD1L1

3.34e-051928555e709c0714e8eba27e03a6def0544256bedb3ced
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RELN RARRES2 CYP4X1 PRKCZ PKHD1L1

3.34e-051928555f4f44f15d3a2846981e68296643a4634930a211
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN FLT3 PAM TNFSF15 ADGRG6

3.34e-05192855dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN FLT3 PAM TNFSF15 ADGRG6

3.42e-05193855c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CELSR1 SPATA6L EGFR CEP126 GRM7

3.42e-05193855ea345d34440b25f65358a53dc72831998d1c3620
ToppCellPBMC-Control-cDC_11|Control / Compartment, Disease Groups and Clusters

FLT3 GRAP2 PRKCZ LRBA ANKRD20A1

3.60e-0519585574d560ff0f47512441c305885c5c16272f711b8e
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

SPATA6L RHBG TREH CAPSL CEP126

3.60e-0519585560067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellLPS-IL1RA-Unknown-Endothelial-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NPFFR2 RELN CYP17A1 PKD1

9.66e-051258542938a1d62afe1e0a3abba5eb92f07b886cc0accd
ToppCellCOVID-19_Mild-Neu_1|World / 5 Neutrophil clusters in COVID-19 patients

RELN GRB14 GRM7 ERBIN

9.66e-05125854e58c208b4355252ceabe04a468dd19a1f436182c
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN DGKB MMP26 GRM7

1.85e-04148854d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar-Club_cell|E18.5-samps / Age Group, Lineage, Cell class and subclass

CELSR1 RHBG CAPSL ITGA7

1.90e-0414985482edfecb7981d8c336cf9da7aa7e2b3f7a017a3f
ToppCellE18.5-samps-Epithelial-Epithelial-non_alveolar|E18.5-samps / Age Group, Lineage, Cell class and subclass

CELSR1 RHBG CAPSL ITGA7

1.90e-0414985414a01ae540db8a350ea26a350b2e6ce6c07639d9
ToppCellCOVID-19_Mild|World / 5 Neutrophil clusters in COVID-19 patients

RELN CELSR1 OSBPL3 ERBIN

2.05e-041528542ff0980dfd8d430cca14649151d856edef115720
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FLT3 TNFSF15 FKBP14 ADGRG6

2.10e-0415385491e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT3 TNFSF15 FKBP14 ADGRG6

2.10e-04153854f17f62646633cf95c810dcd5328978058741b276
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-CLP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ENAM FLT3 CELSR1 OSBPL3

2.32e-04157854d12f343454202da86a06d0369f8ffe5662cd091b
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN WDHD1 MFSD4A KLHL8

2.43e-041598544000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell18-Airway-Epithelial-Bud_tip_progenitor|Airway / Age, Tissue, Lineage and Cell class

RHBG CYP17A1 GRB14 TNFSF15

2.43e-04159854e715cadff8e7d5ebe4c2198dbdfd3ca41ecb8a6a
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN WDHD1 MFSD4A KLHL8

2.43e-041598547619d0d49738dd08daf01b42664691a5323aa793
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPPA4 BAAT PKHD1L1 SFMBT2

2.61e-04162854bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

RELN CYP4X1 ZNF396 PKHD1L1

2.68e-04163854961c3a1303108afd680365466045f3460a30a7b0
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1

2.74e-041648544cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1

2.74e-041648547a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellwk_20-22-Hematologic-Myeloid-HSC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FLT3 CD244 DPPA4 ATP2A1

2.74e-04164854a35a0725b8bfe3cad5b85484217fd8a02bdee827
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1

2.74e-041648545e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN CELSR1 MFSD4A PKHD1L1

2.74e-04164854f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellNS-control-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DPPA4 TRPM2 ATP2A1 SFMBT2

2.80e-041658548b2d43d7c4ee07bd999bd51bc15117ce1fbb2d86
ToppCellcontrol-Myeloid-pDC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DPPA4 TRPM2 ATP2A1 SFMBT2

2.80e-04165854243c74adf8d993ff92acbff2768bdc5a1693eca3
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D175|Adult / Lineage, Cell type, age group and donor

VWF ANKRD20A4P DYRK4 ADGRG6

3.07e-04169854e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCellControl-Hematopoietic_Meg-Ery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF24 GRAP2 PKHD1L1 DCAF12

3.07e-04169854c2e2a7b89fe4a64d79efafdec037c4104f433061
ToppCelldroplet-Lung-nan-3m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GRAP2 DZIP1 SESN1

3.07e-041698549df20ce0c2661eb4b3ce4c0b857e38485fabd46d
ToppCellControl-Hematopoietic_Meg-Ery-Erythroid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF24 GRAP2 PKHD1L1 DCAF12

3.07e-04169854df1fc1477bbbb285063b9b122b1ac84c87fd7fa8
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 GRAP2 DZIP1 SESN1

3.07e-041698547ec2b6b55f51edc0084db73eaf42ae319a24f77a
ToppCellNS-critical-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RARRES2 EGFR CYP4X1 MFSD4A

3.07e-04169854aec97583b23112060437b619cb429dc32f29285f
ToppCellControl-Hematopoietic_Meg-Ery-Erythroid-Erythroid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZNF24 GRAP2 PKHD1L1 DCAF12

3.07e-0416985492986559aa4a744e8b0487b0ae035cfb1fbf9890
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA HEXB SESN1 DSE

3.14e-041708546ec0cf055ae55e9fac147f7989c47f83ab07270c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT3 DPPA4 TRPM2 SFMBT2

3.21e-0417185439c8ae139e449217091e1481eb5e2aafb8f69a1c
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

RELN GRAP2 MMP26 GRM7

3.21e-04171854b2e753e811a7639956994609f73efcdb62d04f82
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEXA HEXB SESN1 DSE

3.28e-04172854c96bd3407911df3e3e6d7a3dba786b11814b9598
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL3 MFSD4A DZIP1 LRBA

3.28e-041728541565f38266891c3acf49778838de134c5dee5460
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

VWF GRB14 MFSD4A ADGRG6

3.35e-04173854ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCellAT1_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

CD244 EGFR PAM PRKCZ

3.35e-041738543afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

VWF GRB14 MFSD4A ADGRG6

3.35e-0417385422200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CELSR1 PRKCZ PKHD1L1

3.50e-04175854f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPATA6L EGFR SACS ADGRG6

3.58e-0417685433323c97afe509147956b8df9f92ca6b0537e604
ToppCellNS-critical-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPATA6L RARRES2 CYP17A1 DZIP1

3.58e-04176854b794275fdd757b8fa2108e3c867f23da2649146d
ToppCellAdult-Epithelial-club_cell-D175|Adult / Lineage, Cell type, age group and donor

CELSR1 MFSD4A BOLA2 FGFR3

3.66e-04177854d652b7d84fe6aa38319d8d5adc72c70441bd0088
ToppCellP28-Endothelial-lymphatic_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN CELSR1 PRKCZ PKHD1L1

3.66e-041778546e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RELN GRB14 ITGA7 ADGRG6

3.66e-0417785459cf56c385c324f0844f20003d2b5049a2791e45
ToppCellP28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN CELSR1 PRKCZ PKHD1L1

3.66e-04177854e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GBP6 CYP4X1 DGKB ITGA7

3.66e-04177854d731400997afea379f47ae8aa0f82802962b0861
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPSL DGKB GRB14 FGGY

3.82e-041798547c8a2fa1326c73dc9e774df645b572864fd97133
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELSR1 EGFR OSBPL3 PRKCZ

3.82e-0417985404ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

OSBPL3 MFSD4A DZIP1 LRBA

3.90e-041808549e09b3dfe344b5d50520711513d389865d73a861
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP6 OSBPL3 GRAP2 SFMBT2

3.90e-041808545c649e2b3f5a53c0040b69df6e289fb3427ef2db
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENAM RARRES2 EGFR MMP26

3.98e-0418185440df0afcb6848202da54670e84f22d7c3a515d01
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN CELSR1 VWF PKHD1L1

3.98e-04181854cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CELSR1 EGFR OSBPL3 PRKCZ

3.98e-04181854b45b11428d13950369347e051d4d517efb2bd4fd
ToppCellfacs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 EGFR ARHGAP27 ATP2A1

3.98e-04181854782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENAM RARRES2 EGFR MMP26

3.98e-041818542b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENAM RARRES2 EGFR MMP26

3.98e-041818546aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCellfacs-Marrow-B-cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 EGFR ARHGAP27 ATP2A1

3.98e-04181854e2481291c236105774c53883e6f20da11941df9b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

TNRC18 MFSD4A FGFR3 GRM7

3.98e-04181854c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ENAM RARRES2 EGFR MMP26

3.98e-0418185440d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCellwk_15-18-Hematologic-Meg-ery-Definitive_erythroblast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ANKRD20A4P ATG9A ANKRD20A1 DCAF12

4.06e-0418285493841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

EGFR RHBG OSBPL3 TBL1X

4.06e-04182854ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENAM RELN CELSR1 PKHD1L1

4.06e-04182854d22ab50b135482915687c70e6dad29bfe2bb2c68
DiseaseAdenocarcinoma of large intestine

EGFR TBK1 FGFR3 PRKCZ

1.44e-0496814C1319315
Disease7-methylguanine measurement

ELP2 MMP26

2.06e-048812EFO_0021123
Diseasesevere acute respiratory syndrome, COVID-19

RELN TRPM2 DGKB ELP2 GRM7 FGGY TBL1X

2.31e-04447817EFO_0000694, MONDO_0100096
Diseasehigh grade glioma (implicated_via_orthology)

EGFR FGFR3 PRKCZ

2.43e-0444813DOID:3070 (implicated_via_orthology)
Diseaseschizophrenia (is_marker_for)

RELN VWF EGFR

2.43e-0444813DOID:5419 (is_marker_for)
Diseaseouter ear morphology trait

LRBA ADGRG6

4.83e-0412812EFO_0007664
DiseaseFVC change measurement, response to placebo

RELN DGKB

5.69e-0413812EFO_0008344, EFO_0010339
Diseasecarcinoma (implicated_via_orthology)

FLT3 EGFR PRKCZ

7.36e-0464813DOID:305 (implicated_via_orthology)
Diseasegliosarcoma

EGFR FGFR3

8.71e-0416812C0206726
Diseaseidiopathic scoliosis (implicated_via_orthology)

MBTPS1 ADGRG6

8.71e-0416812DOID:0060250 (implicated_via_orthology)
Diseasediabetes mellitus

GRB14 PAM FGFR3

8.78e-0468813EFO_0000400
Diseasecortical surface area measurement

HEXB RELN CELSR1 EGFR TREH PKD1 PAM FGFR3 PRKCZ ARHGAP27 PTPN20

1.10e-0313458111EFO_0010736
Diseasetype 1 diabetes mellitus (biomarker_via_orthology)

VWF EGFR

1.23e-0319812DOID:9744 (biomarker_via_orthology)
Diseasebipolar disorder (is_marker_for)

RELN VWF

1.23e-0319812DOID:3312 (is_marker_for)
Diseasedilated cardiomyopathy

BAG3 PKD1

1.37e-0320812EFO_0000407
DiseaseAutism Spectrum Disorders

RELN TET3 TBL1X

1.67e-0385813C1510586
DiseaseParkinson disease

CYP17A1 TRPM2 BAG3 PAM ARHGAP27

1.93e-03321815MONDO_0005180
Diseaseputamen volume change measurement, age at assessment

DPPA4 CAPSL

2.50e-0327812EFO_0008007, EFO_0021495

Protein segments in the cluster

PeptideGeneStartEntry
PTQHFKNQFPALHWE

TNFSF15

106

O95150
KNQFPALHWEHELGL

TNFSF15

111

O95150
KTARNTPNWDFHNHE

ANKRD20A1

491

Q5TYW2
QAQECGHLHVVNPDW

CTDP1

696

Q9Y5B0
LWHSKQNPQIDHASF

ERBIN

991

Q96RT1
GEVIPHAAAQEHAWK

BAAT

386

Q14032
EEHPSHKAVWNVLGN

BAG5

361

Q9UL15
KTARNTPNWDFHNHE

ANKRD20A4P

491

Q4UJ75
QEVHHPICAFWDLNK

ADGRG6

796

Q86SQ4
VHLQFHAGQAWVPEK

DPPA4

246

Q7L190
HIHAFEQKTLTPDQW

BOLA2

66

Q9H3K6
PKNNLVIFHRGDHVW

PAM

521

P19021
GHVLQHESWQQGFDL

CELSR1

2161

Q9NYQ6
PWDQAALAKVAQHHL

DNHD1

3046

Q96M86
VWLINIGHFNDPVHG

ATP2A1

271

O14983
NPGVVHFDKNEHWSA

MMP26

181

Q9NRE1
AAVPHTGRKNQEQWH

NPFFR2

351

Q9Y5X5
QVALEEFHKHPPVQW

RARRES2

31

Q99969
EFHKHPPVQWAFQET

RARRES2

36

Q99969
ALQAEKMNHHPEWFN

PCBD2

81

Q9H0N5
THKHNNGQPIWFTLG

FKBP14

66

Q9NWM8
GRAVHKEFQQNNWHA

MAT2B

41

Q9NZL9
KNDPLDWNGDHIHTN

MBTPS1

646

Q14703
LGQHHVDAKPWSNQT

MFSD4A

191

Q8N468
NPQHHSKWLDETLAQ

KLHL8

241

Q9P2G9
AVNKWHNLPAHQGAV

LRBA

2546

P50851
NINHFGHPWLKQHFA

DSE

281

Q9UL01
KGWRNFNAGHEHPDQ

DSE

441

Q9UL01
WPLVQKALNEHHVNA

KRR1

76

Q13601
HTQKVQNDWLHEGFK

GBP6

551

Q6ZN66
DHNQPLFGVQFNWHS

EED

91

O75530
HKDEIFQVQWSPHNE

RBBP4

316

Q09028
NNGITWHVIAQHQPK

RELN

3366

P78509
WHVIAQHQPKDFTQA

RELN

3371

P78509
HSVKQLQFTKWPDHG

PTPN20

311

Q4JDL3
HVNHGFGLTWELENK

FLT3

276

P36888
PDQALKHAWIHQSRN

DYRK4

391

Q9NR20
FDSPAHWAQKGSHQI

EGFR

1151

P00533
NAKHHPKYQNGEWSE

CAPSL

141

Q8WWF8
DAQGPQFGWDHSLHK

DCAF12

21

Q5T6F0
IKNWEPQFNHHEQSS

FGGY

41

Q96C11
KHVLPTEHSLNQWNQ

CEP126

841

Q9P2H0
LHKQQAQAEPERHVW

ATG9A

716

Q7Z3C6
HNEKEWHQPDQFMPE

CYP17A1

401

P05093
THWFLGHQKFIQDDN

CYP4X1

51

Q8N118
DLQHHEQWLVGGPLF

CARD8

221

Q9Y2G2
DDGQHVWRLKHFNKP

DGKB

241

Q9Y6T7
WGSKINPLHQHEDIA

GRM7

316

Q14831
SQPWFHHKISRDEAQ

GRB14

436

Q14449
EPKHQASGTVWLKHQ

ITGA7

596

Q13683
AKEHFPAGRNTWDHQ

ENAM

556

Q9NRM1
FHGALHLWKQNTVNP

ELP2

361

Q6IA86
AQPHIQWLKHVEVNG

FGFR3

281

P22607
PKWFHEGLSRHQAEN

GRAP2

56

O75791
WHHEPAEFQAKTQVQ

HEXB

111

P07686
QTHQPVYHKIQGDDW

BAG3

241

O95817
FLGEKDWHPENQNLS

RSC1A1

146

Q92681
WHPDKNPENHDIANE

SACS

4336

Q9NZJ4
LLPSQNGFHHILKWE

CD244

56

Q9BZW8
HVTLPVFGDHFEWNK

OSBPL3

671

Q9H4L5
HDNKGLSPAWFLQHV

PKD1

3186

P98161
NKLNVFHWHLVDDPS

HEXA

196

P06865
ERFHPGSQSTWKNIH

SPATA6L

331

Q8N4H0
LHVNDFLHVGGDPKW

SESN1

136

Q9Y6P5
HFTQEQWVRLEDPHG

ARHGAP27

411

Q6ZUM4
AHFSENLIKHVQGWP

WAC

561

Q9BTA9
NLIKHVQGWPADHAE

WAC

566

Q9BTA9
QGILQQFEHWPHICT

TDRD7

271

Q8NHU6
PAKNEPHFAHVLNAW

DZIP1

816

Q86YF9
FGQTTIHQHIPFNWD

SLC25A13

116

Q9UJS0
WDAHTGEAKQQFPFH

TBL1X

356

O60907
SPGKQFHQGQHWDQK

TNRC18

2866

O15417
KELQTWVRDHHPENG

ZNF24

106

P17028
DGVQHQFLEAWVPDH

VWF

2261

P04275
SQHYEDQVHWQVPGE

RHBG

426

Q9H310
WAQVLKALNHHFPES

TINF2

76

Q9BSI4
HTFQGTQWDPKKHVQ

TRPM2

106

O94759
KSDHYWVVGIHENPQ

WDHD1

671

O75717
NQQEEIDIWGKHHIY

ZNF267

176

Q14586
DWADYHKQHGAQEAP

SFMBT2

381

Q5VUG0
HEHFQAKGQELQPWT

TREH

91

O43280
PNANHINWYFKGVDH

PKHD1L1

2891

Q86WI1
HKNLNQPNHGLALWE

TET3

1696

O43151
GFHANEFVVWNPRSH

WDR6

631

Q9NNW5
WHQLGLVLAKHFEPQ

UBL4B

91

Q8N7F7
WHQQIHTGVKPFECN

ZNF543

356

Q08ER8
KELQAWVQKHHPENG

ZNF396

106

Q96N95
WVQKHHPENGEETVT

ZNF396

111

Q96N95
DLQQQALHSGWKPHR

ZNF17

161

P17021
WAHQEGTHPKDRNVE

TBK1

536

Q9UHD2
HQQHPLTLKWVDSEG

PRKCZ

51

Q05513