Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	4.79e-05	4	57	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	1.19e-04	6	57	2	GO:0048763
MousePheno	increased susceptibility to malignant hyperthermia	RYR1 HTT	8.81e-06	2	42	2	MP:0020214
MousePheno	abnormal adaptive thermogenesis	KDM3A CES1 RYR1 C2CD5 HTT	9.57e-06	96	42	5	MP:0011019
MousePheno	abnormal common bile duct morphology	PKD1 HES1	5.27e-05	4	42	2	MP:0009495
MousePheno	impaired learning	FOXN1 HPRT1 UQCRC1 GRM5 RYR3	7.23e-05	146	42	5	MP:0012315
MousePheno	increased triglyceride level	RALGAPA1 KDM3A GALR3 CES1 SCRIB SIRT3 C2CD5	7.91e-05	354	42	7	MP:0005317
MousePheno	increased fat cell size	RALGAPA1 KDM3A CES1 C2CD5	8.55e-05	78	42	4	MP:0006094
MousePheno	decreased oxygen consumption	KDM3A CES1 SIRT3 C2CD5	8.98e-05	79	42	4	MP:0005290
MousePheno	increased liver cholesterol level	RALGAPA1 CES1 SIRT3	1.41e-04	34	42	3	MP:0010027
MousePheno	increased liver triglyceride level	RALGAPA1 CES1 SIRT3 C2CD5	2.70e-04	105	42	4	MP:0009355
MousePheno	lethality throughout fetal growth and development	PKD1 LAMA5 HES1 SCRIB TACC3 RYR1 HTT	2.83e-04	435	42	7	MP:0006208
MousePheno	increased rib number	PGAP1 ASH1L PHC2	2.86e-04	43	42	3	MP:0000480
MousePheno	insulin resistance	RALGAPA1 KDM3A CES1 SIRT3 C2CD5	2.94e-04	197	42	5	MP:0005331
MousePheno	thin ribs	FLNB RYR1	3.13e-04	9	42	2	MP:0004674
MousePheno	neuronal intranuclear inclusions	HPRT1 HTT	3.13e-04	9	42	2	MP:0004191
MousePheno	small lung	PKD1 LAMA5 HES1 SCRIB	3.82e-04	115	42	4	MP:0003641
Domain	Ryanrecept_TM4-6	RYR1 RYR3	2.74e-05	3	57	2	IPR009460
Domain	RyR	RYR1 RYR3	2.74e-05	3	57	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	2.74e-05	3	57	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	2.74e-05	3	57	2	PF06459
Domain	Ryan_recept	RYR1 RYR3	2.74e-05	3	57	2	IPR013333
Domain	RIH_assoc	RYR1 RYR3	1.36e-04	6	57	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	1.36e-04	6	57	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	1.36e-04	6	57	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	1.36e-04	6	57	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	1.36e-04	6	57	2	IPR015925
Domain	-	RYR1 RYR3	1.36e-04	6	57	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR3	1.36e-04	6	57	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR3	1.36e-04	6	57	2	PF08709
Domain	MIR	RYR1 RYR3	4.05e-04	10	57	2	PS50919
Domain	MIR	RYR1 RYR3	4.05e-04	10	57	2	PF02815
Domain	MIR	RYR1 RYR3	4.05e-04	10	57	2	SM00472
Domain	MIR_motif	RYR1 RYR3	4.05e-04	10	57	2	IPR016093
Domain	SUGAR_TRANSPORT_2	SLC22A3 SLC2A11	1.21e-03	17	57	2	PS00217
Domain	SPRY	BSPRY RYR1 RYR3	2.38e-03	87	57	3	SM00449
Domain	SUGAR_TRANSPORT_1	SLC22A3 SLC2A11	2.42e-03	24	57	2	PS00216
Domain	SPRY	BSPRY RYR1 RYR3	2.97e-03	94	57	3	PF00622
Domain	SPRY_dom	BSPRY RYR1 RYR3	2.97e-03	94	57	3	IPR003877
Domain	B30.2/SPRY	BSPRY RYR1 RYR3	3.06e-03	95	57	3	IPR001870
Domain	B302_SPRY	BSPRY RYR1 RYR3	3.06e-03	95	57	3	PS50188
Domain	Sugar_transporter_CS	SLC22A3 SLC2A11	4.28e-03	32	57	2	IPR005829
Domain	ConA-like_dom	BSPRY LAMA5 RYR1 RYR3	4.47e-03	219	57	4	IPR013320
Domain	PDZ	TJP1 HTRA3 SCRIB	9.15e-03	141	57	3	PF00595
Pubmed	Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus.	CES1P1 CES1	2.83e-06	2	59	2	26871237
Pubmed	Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease.	GRM5 HTT	2.83e-06	2	59	2	20053912
Pubmed	Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.	HPRT1 PKD1	2.83e-06	2	59	2	23064367
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	2.83e-06	2	59	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	2.83e-06	2	59	2	9489997
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	2.83e-06	2	59	2	9192302
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	2.83e-06	2	59	2	12640042
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	2.83e-06	2	59	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	2.83e-06	2	59	2	14592949
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	2.83e-06	2	59	2	15894801
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	2.83e-06	2	59	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	2.83e-06	2	59	2	9817784
Pubmed	Unraveling the Role of Huntingtin in Breast Cancer Metastasis.	TJP1 HTT	2.83e-06	2	59	2	26293574
Pubmed	Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro.	CES1P1 CES1	2.83e-06	2	59	2	17264798
Pubmed	Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.	GRM5 HTT	2.83e-06	2	59	2	24282028
Pubmed	Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice.	GRM5 HTT	2.83e-06	2	59	2	30961637
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	2.83e-06	2	59	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	2.83e-06	2	59	2	11500519
Pubmed	Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina.	NUMBL TJP1 HES1	3.10e-06	17	59	3	23197712
Pubmed	Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome.	FOXN1 TJP1 HES1	3.72e-06	18	59	3	31412026
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	8.48e-06	3	59	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	8.48e-06	3	59	2	11171121
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	8.48e-06	3	59	2	18313230
Pubmed	Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.	CES1P1 CES1	8.48e-06	3	59	2	20195289
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	8.48e-06	3	59	2	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	8.48e-06	3	59	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	8.48e-06	3	59	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	8.48e-06	3	59	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	8.48e-06	3	59	2	12213830
Pubmed	Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms.	CES1P1 CES1	8.48e-06	3	59	2	10452915
Pubmed	Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin.	GRM5 HTT	8.48e-06	3	59	2	23230231
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	8.48e-06	3	59	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	8.48e-06	3	59	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	8.48e-06	3	59	2	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	8.48e-06	3	59	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	8.48e-06	3	59	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	8.48e-06	3	59	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	8.48e-06	3	59	2	11159936
Pubmed	Sirt3 promotes the autophagy of HK‑2 human proximal tubular epithelial cells via the inhibition of Notch‑1/Hes‑1 signaling.	HES1 SIRT3	8.48e-06	3	59	2	34278469
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	8.48e-06	3	59	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	8.48e-06	3	59	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	8.48e-06	3	59	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	8.48e-06	3	59	2	7635066
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	1.69e-05	4	59	2	22100703
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	1.69e-05	4	59	2	18206662
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	1.69e-05	4	59	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	1.69e-05	4	59	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	1.69e-05	4	59	2	9607712
Pubmed	Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.	CES1P1 CES1	1.69e-05	4	59	2	18794728
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	1.69e-05	4	59	2	23482488
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TBCB FLNB TJP1 HPRT1 NUP88 PSD3 UBR3 SCRN1 GRM5 BEGAIN	1.99e-05	1139	59	10	36417873
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TMEM144 PKD1 ASH1L NUP88 UQCRC1 SCRIB HTT PIGM	2.25e-05	697	59	8	28298427
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	2.82e-05	5	59	2	23918386
Pubmed	Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.	PKD1 RYR1	2.82e-05	5	59	2	11818962
Pubmed	mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington's disease.	GRM5 HTT	2.82e-05	5	59	2	32859226
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	2.82e-05	5	59	2	19011160
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	RALGAPA1 KDM3A MINDY3 VPS52 NUP88 UQCRC1 C2CD5	3.27e-05	533	59	7	25544563
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALGAPA1 FLNB TMEM144 NUMBL TJP1 SLC22A3 ASH1L RPRD2 UQCRC1 SLC2A11 HTT	3.60e-05	1489	59	11	28611215
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	4.23e-05	6	59	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR3	4.23e-05	6	59	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR3	4.23e-05	6	59	2	23463619
Pubmed	CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties.	FOXN1 HPRT1	4.23e-05	6	59	2	31017901
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	4.23e-05	6	59	2	10444070
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR3	4.23e-05	6	59	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR3	4.23e-05	6	59	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR3	4.23e-05	6	59	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	4.23e-05	6	59	2	19009018
Pubmed	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	CES1P1 CES1	4.23e-05	6	59	2	20931200
Pubmed	Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.	HPRT1 HES1	4.23e-05	6	59	2	22146645
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR3	4.23e-05	6	59	2	16844763
Pubmed	The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.	HPRT1 SLC22A3	4.23e-05	6	59	2	31329595
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	FLNB HPRT1 LAMA5 RPRD2 TACC3 PHC2 BEGAIN	4.47e-05	560	59	7	21653829
Pubmed	Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.	TJP1 HPRT1	5.91e-05	7	59	2	26114479
Pubmed	Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice.	TJP1 HES1	5.91e-05	7	59	2	19551907
Pubmed	Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.	TJP1 SCRIB	5.91e-05	7	59	2	28369449
Pubmed	The enigma of the numb-Notch relationship during mammalian embryogenesis.	NUMBL HES1	5.91e-05	7	59	2	16508312
Pubmed	Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection.	FOXN1 HLA-DMA	5.91e-05	7	59	2	35997680
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR3	5.91e-05	7	59	2	11860456
Pubmed	Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells.	TJP1 HES1	5.91e-05	7	59	2	18292208
Pubmed	Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.	SIRT3 HTT	5.91e-05	7	59	2	22956852
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR3	5.91e-05	7	59	2	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR3	7.87e-05	8	59	2	19033399
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR1 RYR3	7.87e-05	8	59	2	21441923
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR1 RYR3	7.87e-05	8	59	2	30563862
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR3	7.87e-05	8	59	2	11784029
Pubmed	Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.	TJP1 SCRIB	1.01e-04	9	59	2	28169360
Pubmed	Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.	ITGAX PHC2	1.01e-04	9	59	2	16815646
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	RYR1 RYR3	1.01e-04	9	59	2	21858002
Pubmed	Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.	KDM3A RYR1 HTT	1.02e-04	53	59	3	36265442
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	TBCB HIGD1A FLNB HPRT1 NUP88 UQCRC1 TACC3 HTT	1.14e-04	878	59	8	37223481
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	MINDY3 VPS52 TJP1 C2CD5	1.16e-04	147	59	4	29576527
Pubmed	The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.	TJP1 SCRIB	1.26e-04	10	59	2	26376988
Pubmed	Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.	TJP1 SCRIB	1.26e-04	10	59	2	19071123
Pubmed	Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2.	TJP1 SCRIB	1.26e-04	10	59	2	19363157
Pubmed	Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation.	TJP1 SCRIB	1.54e-04	11	59	2	26114487
Pubmed	Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.	TJP1 SCRIB	1.54e-04	11	59	2	17556662
Pubmed	Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse.	TJP1 SCRIB	1.54e-04	11	59	2	24095903
Pubmed	Evidence for a functional second thymus in mice.	FOXN1 ITGAX	1.54e-04	11	59	2	16513945
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR3	1.85e-04	12	59	2	19095005
Pubmed	Microtubules enable the planar cell polarity of airway cilia.	TJP1 HPRT1	1.85e-04	12	59	2	23122850
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	1.09e-05	3	35	2	287
ToppCell	COVID-19-COVID-19_Severe-Myeloid-pDC\|COVID-19_Severe / Disease, condition lineage and cell class	HIGD1A FLNB RPS6KA4 HLA-DMA BSPRY SCRN1	2.50e-07	198	59	6	033ed362333e1d33f2aeea8da5865d2228d154dc
ToppCell	facs-Marrow-KLS-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR155 NUMBL BSPRY PKD1 ITGAX	2.09e-06	157	59	5	5d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCell	facs-Marrow-KLS-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR155 NUMBL BSPRY PKD1 ITGAX	2.09e-06	157	59	5	ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCell	Healthy/Control-cDC\|World / Disease group and Cell class	RPS6KA4 HLA-DMA SCRN1 ITGAX RYR1	6.32e-06	197	59	5	4497d4073f4d3e74de907325fba9eb4af5766bf4
ToppCell	Healthy_donor-cDC\|World / disease group, cell group and cell class (v2)	RPS6KA4 HLA-DMA SCRN1 ITGAX RYR1	6.32e-06	197	59	5	a545fe3a80cd721bf01115bbb645753840ec9f40
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RPS6KA4 HLA-DMA SCRN1 ITGAX RYR1	6.48e-06	198	59	5	d0371e2ca9e25727b35985940f6228f9d8e49727
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RPS6KA4 HLA-DMA SCRN1 ITGAX RYR1	6.48e-06	198	59	5	08ad0bece508bb4f9cc126d94839b5c89ce21ba8
ToppCell	mild-cDC\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS6KA4 HLA-DMA SCRN1 ITGAX RYR1	6.80e-06	200	59	5	d6409ee5b9067be3dd2f852825e09151b5b22d7c
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMEM144 HLA-DMA TACC3 RYR1	5.46e-05	156	59	4	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HLA-DMA TACC3 ITGAX RYR1	6.17e-05	161	59	4	0e2b54a63781397f6b99eb0e201fbb820cbd7cc6
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DMA SLC39A11 ITGAX RYR1	6.17e-05	161	59	4	ed93cb6c133855a5c244821e1a260aae8ab4df9a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HLA-DMA SLC39A11 ITGAX RYR1	6.17e-05	161	59	4	0089d7bb305c592392791862a3341fc92af8f3e2
ToppCell	droplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB HLA-DMA ITGAX RYR1	6.94e-05	166	59	4	c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HLA-DMA SLC22A3 HES1 RYR3	7.27e-05	168	59	4	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB HLA-DMA ITGAX RYR1	7.44e-05	169	59	4	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive\|bone_marrow / Manually curated celltypes from each tissue	HLA-DMA HES1 TRMT5 RYR1	7.79e-05	171	59	4	fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCell	COVID_vent-Lymphocytic-Dendritic-pDC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	HIGD1A FLNB HLA-DMA SCRN1	7.79e-05	171	59	4	779c951d274ecbd1d546ac425d6c8e718623be5a
ToppCell	COVID_vent-Lymphocytic-Dendritic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	HIGD1A FLNB HLA-DMA SCRN1	7.79e-05	171	59	4	debbb071d260639b16269c94d172766908325c58
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs\|normal_Pleural_Fluid / Location, Cell class and cell subclass	RPS6KA4 PSD3 SCRN1 ITGAX	7.97e-05	172	59	4	200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL FLNB SLC22A3 LAMA5	9.10e-05	178	59	4	cc0382b0ee1e6c76522e2c86ad1425c45debab5d
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL FLNB SLC22A3 LAMA5	9.50e-05	180	59	4	41e8155cc7b3dac9d496e4077845ca6af1591a5c
ToppCell	HSPCs-LMPPs\|World / Lineage and Cell class	NPL HLA-DMA SLC22A3 SIRT3	1.01e-04	183	59	4	e401f06843528a75693ce455bbeff2a98b8c24e5
ToppCell	Mild/Remission-B_intermediate-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TBCB FLNB HES1 ITGAX	1.03e-04	184	59	4	3d4864605c812862cf8926e02370eea3b8ccf32f
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL FLNB SLC22A3 LAMA5	1.06e-04	185	59	4	5527fa9d2e0b2f3607602e18ba94de4e9bbc6824
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPL GPR155 PSD3 RYR1	1.06e-04	185	59	4	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	LAM-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	HIGD1A FLNB RPS6KA4 HLA-DMA	1.10e-04	187	59	4	4d9ffd2bbdf1c9869e28991ce9331e4ccf3c0166
ToppCell	control-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.10e-04	187	59	4	c78aee98b32719aa45811b620fc97be1ecf5fd53
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_8\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPS6KA4 HLA-DMA HES1 RYR1	1.12e-04	188	59	4	8431991e68b8e9c5eb72212460f6da679ea3b85a
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_8\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RPS6KA4 HLA-DMA HES1 RYR1	1.12e-04	188	59	4	d8f10b3ad11bc99a63f44560e39791085256e5c8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPR155 FLNB OXNAD1 TMEM41B	1.15e-04	189	59	4	e9df7ecd36bee1fedce23bb188c68a94fa60462c
ToppCell	Control-Myeloid-pDC\|Control / Disease group, lineage and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.15e-04	189	59	4	46770b99da42f11f10cfc67cea8562342d60b867
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DMA TJP1 HES1 ITGAX	1.17e-04	190	59	4	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HIGD1A FLNB RPS6KA4 BSPRY	1.17e-04	190	59	4	adffa93635da10251f28b2089fd96b189775c8b4
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPL GPR155 PSD3 RYR1	1.17e-04	190	59	4	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIGD1A FLNB RPS6KA4 BSPRY	1.17e-04	190	59	4	9a91bf1ea105029e6412d0d9060bca325299ce26
ToppCell	PBMC-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	HIGD1A FLNB RPS6KA4 BSPRY	1.17e-04	190	59	4	39c8ddc2639bf3e986dae11fbae61a735614b604
ToppCell	PBMC-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIGD1A FLNB RPS6KA4 BSPRY	1.17e-04	190	59	4	2c1c079fd411c03bc3f383aa927eea9446716960
ToppCell	myeloid-pDC\|World / Lineage and Cell class	HIGD1A FLNB RPS6KA4 HLA-DMA	1.17e-04	190	59	4	88c42779ce2f817d28e672d83f3f1158581edf73
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HIGD1A FLNB RPS6KA4 BSPRY	1.17e-04	190	59	4	a95aea3aa707fc4574810706341a5f32b3d00209
ToppCell	PBMC-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIGD1A FLNB RPS6KA4 BSPRY	1.17e-04	190	59	4	18dfa84c62dcf081ce9958a71e76a394ec0968e4
ToppCell	COVID-19_Severe-pDC\|COVID-19_Severe / disease group, cell group and cell class	HIGD1A FLNB RPS6KA4 HLA-DMA	1.17e-04	190	59	4	c5ab6b7492fb86aff3d2af3eb671c9f985ae4aeb
ToppCell	10x5'v1-week_14-16-Myeloid_DC-DC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RPS6KA4 HLA-DMA CES1 SCRN1	1.17e-04	190	59	4	d06800ec9f6065c1cc536ed99e8569732272a94f
ToppCell	10x5'v1-week_14-16-Myeloid_DC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RPS6KA4 HLA-DMA CES1 SCRN1	1.17e-04	190	59	4	485073e831afebdb393c7f4b622504d43d1b778b
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DMA HES1 ITGAX RYR1	1.19e-04	191	59	4	6cda82a994f4b205cf54590c979d7c9f3be2b4c8
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DMA HES1 ITGAX RYR1	1.19e-04	191	59	4	4257f02856f3510981e9f84d465d91448d6126e2
ToppCell	COVID-19_Moderate-pDC\|COVID-19_Moderate / disease group, cell group and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.19e-04	191	59	4	9d0ffa65c547e20b4076fd97776d7738cbd453ec
ToppCell	PCW_13-14-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NPL TMEM144 ITGAX RYR1	1.19e-04	191	59	4	09dfad8e1fcaaf94775134796b99e4e3fbb9bf40
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DMA CES1 NAF1 RYR1	1.19e-04	191	59	4	5c0c44612b4cdbf89c0f1f219416374a7541f610
ToppCell	Healthy-pDC\|World / disease group, cell group and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.19e-04	191	59	4	6e1d825dc33b915b95f13ccd237a552160a4be98
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RPS6KA4 HLA-DMA ITGAX RYR1	1.19e-04	191	59	4	92c5a26b90a55831039220341d863cf2940f3c9b
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPS6KA4 HLA-DMA ITGAX RYR1	1.22e-04	192	59	4	6184163dbfca882824cb266bb9030d9f79e3acb0
ToppCell	Healthy-pDC\|Healthy / disease group, cell group and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.22e-04	192	59	4	33d695a28d22b4af111df9591830a33bb7ef7b2d
ToppCell	Control-Myeloid-Monocyte-derived_macrophages\|Control / group, cell type (main and fine annotations)	NPL GPR155 ITGAX RYR1	1.24e-04	193	59	4	a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCell	wk_15-18-Hematologic-Myeloid-Cycling_DC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RPS6KA4 HLA-DMA HPRT1 TACC3	1.24e-04	193	59	4	8e6d31546f7150ab3e8ad4fde075839e6c33842a
ToppCell	control-pDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.24e-04	193	59	4	30a6559c9a9e8941861cb259b4836acccc427e68
ToppCell	facs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPL SLC39A11 SLC22A3 SIRT3	1.27e-04	194	59	4	c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DMA SCRN1 ITGAX RYR1	1.27e-04	194	59	4	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DMA SCRN1 ITGAX RYR1	1.27e-04	194	59	4	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NPL PSD3 ITGAX RYR1	1.27e-04	194	59	4	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RPS6KA4 HLA-DMA SCRN1 RYR1	1.29e-04	195	59	4	4cbc36fb3ef9aef61367d3b37070a9a85fae1418
ToppCell	PCW_10-12-Hematologic_Myeloid\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	NPL HLA-DMA ITGAX RYR1	1.29e-04	195	59	4	6352cd749091cfdbf5cce3c354fa57883cc513e8
ToppCell	Mild/Remission-B_intermediate-6\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TBCB FLNB HES1 ITGAX	1.34e-04	197	59	4	5370dda4a25e3a53d6fe2c887b7dabd7a58462b4
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HIGD1A FLNB RIOK3 HES1	1.37e-04	198	59	4	efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FLNB RPS6KA4 HLA-DMA BSPRY	1.37e-04	198	59	4	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NPL TMEM144 HLA-DMA ITGAX	1.37e-04	198	59	4	243109377d62d20c69e9d1fedc252156e90cda1e
ToppCell	Control-Control-Others-RBC\|Control / Disease, condition lineage and cell class	HIGD1A HLA-DMA BSPRY RYR3	1.40e-04	199	59	4	eb4c52d04f572433c0239bf479d0040a309939a1
ToppCell	MS-Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, condition lineage and cell class	HIGD1A FLNB RPS6KA4 HLA-DMA	1.40e-04	199	59	4	c10c8c9322cad4996e4aa11a8680e3d781644ace
ToppCell	MS-IIF-Myeloid-pDC\|IIF / Disease, condition lineage and cell class	HIGD1A FLNB HLA-DMA BSPRY	1.40e-04	199	59	4	e262ee854e64d87460bee810c14d6cbe744460e8
ToppCell	control-cDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS6KA4 HLA-DMA ITGAX RYR1	1.40e-04	199	59	4	31825ba336603fe940dea6022e18ec25af110f4c
ToppCell	Control-Control-Myeloid-pDC\|Control / Disease, condition lineage and cell class	HIGD1A RPS6KA4 HLA-DMA BSPRY	1.40e-04	199	59	4	8e9cac53fabe497ffa27fca0627eafe883af2534
ToppCell	COVID-19-COVID-19_Mild-Myeloid-pDC\|COVID-19_Mild / Disease, condition lineage and cell class	HIGD1A FLNB RPS6KA4 BSPRY	1.40e-04	199	59	4	9de61e5189d907cc969ac3043d68204f70acc0bf
ToppCell	Sepsis-Bac-SEP-Myeloid-pDC\|Bac-SEP / Disease, condition lineage and cell class	HIGD1A FLNB RPS6KA4 HLA-DMA	1.40e-04	199	59	4	7f6569de050262f3d8d9d41c0f0cc139de85c0cb
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC39A11 ITGAX RYR3 BEGAIN	1.42e-04	200	59	4	9156f8fd61a833891d2f7b7fadd693b81b1e2d5a
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	NPL TMEM144 ITGAX RYR1	1.42e-04	200	59	4	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC39A11 ITGAX RYR3 BEGAIN	1.42e-04	200	59	4	566fe2e78e6f35399ec6aad5964f6d4d8ade82c6
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	NPL TMEM144 ITGAX RYR1	1.42e-04	200	59	4	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	NPL TMEM144 ITGAX RYR1	1.42e-04	200	59	4	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NPL GPR155 HLA-DMA ITGAX	1.42e-04	200	59	4	4b4df0fe47498310d94448b8a289e58e4f5b5aa8
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	NPL TMEM144 ITGAX RYR1	1.42e-04	200	59	4	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NPL GPR155 HLA-DMA ITGAX	1.42e-04	200	59	4	c210b98a75ab5d899d7278bc9b577f76a0b3970c
ToppCell	control-cDC\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS6KA4 HLA-DMA ITGAX RYR1	1.42e-04	200	59	4	4a6d17a4225be38537d3dd8a39512051f597f4e0
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	NPL TMEM144 ITGAX RYR1	1.42e-04	200	59	4	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	NPL TMEM144 ITGAX RYR1	1.42e-04	200	59	4	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA5 TRMT5 ITGAX	1.89e-04	84	59	3	57d549d7c5786d2a74601595df3dc3776f8ff6ea
Drug	PCB 66	HLA-DMA RYR1 RYR3	2.42e-06	11	57	3	CID000036185
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	6.16e-06	2	57	2	ctd:C005147
Drug	2-hydroxycarbazole	RYR1 RYR3	1.84e-05	3	57	2	CID000093551
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	1.84e-05	3	57	2	CID000080262
Drug	cis-diammineplatinum(II	RYR1 RYR3	1.84e-05	3	57	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR3	1.84e-05	3	57	2	CID002750949
Drug	flubendiamide	RYR1 RYR3	1.84e-05	3	57	2	CID011193251
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR3	1.84e-05	3	57	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR3	1.84e-05	3	57	2	CID000127713
Drug	aminodantrolene	RYR1 RYR3	1.84e-05	3	57	2	CID009570289
Drug	A-30	RYR1 RYR3	3.68e-05	4	57	2	CID003028528
Drug	PCB74	RYR1 RYR3	3.68e-05	4	57	2	CID000036218
Drug	148504-47-6	RYR1 RYR3	3.68e-05	4	57	2	CID006444275
Drug	Bastadin 10	RYR1 RYR3	3.68e-05	4	57	2	CID009589366
Drug	SC 38249	RYR1 RYR3	3.68e-05	4	57	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR3	3.68e-05	4	57	2	CID000035682
Drug	caged InsP3	PKD1 RYR1 RYR3	5.19e-05	29	57	3	CID000122248
Drug	benzalazine	HPRT1 GRM5	6.13e-05	5	57	2	CID000092130
Drug	CNS 1145	PKD1 RYR1 RYR3	7.70e-05	33	57	3	CID000190902
Drug	IHC-64	PKD1 RYR1 RYR3	7.70e-05	33	57	3	CID000162753
Drug	MBED	RYR1 RYR3	9.18e-05	6	57	2	CID000129958
Drug	chloro-m-cresol	RYR1 RYR3	9.18e-05	6	57	2	CID000012008
Drug	AC1O528X	RYR1 RYR3	9.18e-05	6	57	2	CID006475857
Drug	NSC114784	RYR1 RYR3	9.18e-05	6	57	2	CID000419425
Drug	NSC692750	RYR1 RYR3	9.18e-05	6	57	2	CID000078910
Drug	1,2-dichlorohexafluorocyclobutane	GRM5 RYR1 RYR3	1.09e-04	37	57	3	CID000009643
Drug	Azumoleno	RYR1 RYR3	1.28e-04	7	57	2	CID000056259
Drug	mag-indo-1	RYR1 RYR3	1.28e-04	7	57	2	CID000131881
Drug	Br2BAPTA	RYR1 RYR3	1.28e-04	7	57	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR3	1.28e-04	7	57	2	CID009547999
Drug	CHEBI:564108	RYR1 RYR3	1.28e-04	7	57	2	CID006400637
Drug	Sulfameter [651-06-9]; Down 200; 14.2uM; HL60; HT_HG-U133A	MINDY3 TMEM144 BSPRY RIOK3 RPRD2	1.34e-04	197	57	5	2712_DN
Drug	ICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A	RALGAPA1 FLNB RPS6KA4 PGAP1 SIRT3	1.34e-04	197	57	5	2698_DN
Drug	loperamide	CES1 PKD1 RYR1 RYR3	1.40e-04	105	57	4	CID000003954
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	1.10e-05	3	57	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	1.10e-05	3	57	2	DOID:8545 (implicated_via_orthology)
Disease	Huntington Disease	NRSN1 HTT	4.89e-04	17	57	2	C0020179
Disease	alcohol use disorder (implicated_via_orthology)	KDM3A PSD3 RYR1 RYR3	5.56e-04	195	57	4	DOID:1574 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	NUMBL HES1	1.16e-03	26	57	2	DOID:1319 (implicated_via_orthology)
Disease	neutrophil count	FLNB HLA-DMA PKD1 ASH1L NUP88 PSD3 RIOK3 RPRD2 HTT	1.25e-03	1382	57	9	EFO_0004833
Disease	waist circumference	RALGAPA1 MINDY3 SLC22A3 PSD3 RIOK3	1.43e-03	429	57	5	EFO_0004342
Disease	hypertrophic cardiomyopathy (implicated_via_orthology)	PKD1 TRMT5	1.44e-03	29	57	2	DOID:11984 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGFAQPVAIFLGIPF	CES1	41	P23141
GLFPAPIHVVFFVSG	ASH1L	2026	Q9NR48
VAAPLEAEVAPGFGR	BEGAIN	356	Q9BUH8
PVGPFDAAPAQVAVF	NUMBL	466	Q9Y6R0
FSAVFTPDGPVLGAV	ITGAX	356	P20702
EAPFVPVGIAGFAAI	HIGD1A	26	Q9Y241
LEGFAQPVAVFLGIP	CES1P1	41	Q9UKY3
FEGGPCAVIAPVQAF	MINDY3	46	Q9H8M7
GDPEPIAAVVFACLG	GRM5	576	P41594
GVFPVAPGVAIFATQ	GPR155	321	Q7Z3F1
GLGFKPFDLVIPFAV	FLNB	1741	O75369
AVGFLVPPKIEAFGE	NRSN1	81	Q8IZ57
DTPGAPVKIIDFGFA	RPS6KA4	541	O75676
AFITVPQRGFGEPFV	LAMA5	976	O15230
ALPFAHVAIAVEGPG	UQCRC1	281	P31930
PDFVGFEIPDKFVVG	HPRT1	176	P00492
VAVRVGGEFFFDPQP	OXNAD1	151	Q96HP4
SPGSVGAVAVPVVFA	GALR3	11	O60755
RPGEFVVAIGSPFAL	HTRA3	251	P83110
GDFGTAFPEIPVEFL	HTT	2426	P42858
IFAFILSFGIGPAGV	SLC2A11	376	Q9BYW1
FLGDVVFIPAGAPHQ	KDM3A	1236	Q9Y4C1
VSFPGPLFPVFAVAD	BSPRY	381	Q5W0U4
VPVEGFGPTFVSAVD	HLA-DMA	166	P28067
PLAEHGVAGAVAVFP	RPRD2	1311	Q5VT52
GVGVTGVVVAFAPNF	SLC22A3	191	O75751
AGVFGAFAVVLAEPI	SLC39A11	276	Q8N1S5
ARDPVGGSVEFQFVP	RYR1	1826	P21817
VDVAPRLFFPEGGAL	FAM87A	196	P0C7U9
FPPGFLVHVGGVVSA	C2CD5	356	Q86YS7
PGFRPHFEVGLAVVV	PKD1	2541	P98161
EAAKVFGGFQVVPAP	HES1	211	Q14469
ETAVAFDFGPLAAVP	NUP88	236	Q99567
PVTFFLIGIPGLEDF	OR52J3	11	Q8NH60
FFFELEPLPGAVEAV	NT5M	101	Q9NPB1
AEIGADGIAVIAPFF	NPL	101	Q9BXD5
VLFDVFAGVGPFAIP	TRMT5	301	Q32P41
VEFDFLGALDIPVPG	TACC3	601	Q9Y6A5
AFIVIPELIAGQPFG	TMC3	161	Q7Z5M5
IPVDVAEAEAFLPGF	FOXN1	161	O15353
PVCTGVVKPDIVFFG	SIRT3	281	Q9NTG7
FPLPLAVGVIAFGSA	PGAP1	886	Q75T13
EVSPGVIANPFAAGI	SCRIB	1201	Q14160
VAFPPRAKDGLVVFG	SCRN1	11	Q12765
PDTFTIAGPGECVFV	CLEC2L	176	P0C7M8
FPEVAVAEGPFITGE	RIOK3	56	O14730
SPPFGGLVAFVKEAE	VPS52	606	Q8N1B4
FVIQEGAEPFPVGRS	PHC2	576	Q8IXK0
VPFFGPLFDGAIVNG	RALGAPA1	1951	Q6GYQ0
AVVSFPIITAGPGFI	TMEM144	291	Q7Z5S9
RDPVGGSVEFQFVPV	RYR3	1711	Q15413
GAFVKPAVVTVGDFP	TBCB	221	Q99426
AGFLRPVTIFGPIAD	TJP1	641	Q07157
SAVADFKAPVFEPGG	UBR3	831	Q6ZT12
IGTFLGVAPPSFVAI	TMEM41B	231	Q5BJD5
VAPAGVFGVAFLARV	PIGM	16	Q9H3S5
VAAVFSAPPFPAAIG	PSD3	896	Q9NYI0
VAVPFFEPVFGEGGI	SLC35E3	201	Q7Z769
AAGKIFEIFGPVAHP	NAF1	236	Q96HR8