Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	1.83e-05	2	86	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	1.83e-05	2	86	2	GO:0103002
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2F1 CYP4A11 CYP4A22	1.46e-04	24	86	3	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2F1 CYP4A11 CYP4A22	2.09e-04	27	86	3	GO:0008391
GeneOntologyMolecularFunction	insulin receptor binding	IGF1 IRS2 SORBS1	2.88e-04	30	86	3	GO:0005158
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	3.80e-04	7	86	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	3.80e-04	7	86	2	GO:0018685
GeneOntologyMolecularFunction	actin filament binding	DSTN CFL1 CFL2 CAMSAP3 MYH15 MYO16	4.45e-04	227	86	6	GO:0051015
GeneOntologyMolecularFunction	aromatase activity	CYP2F1 CYP4A11 CYP4A22	4.57e-04	35	86	3	GO:0070330
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	8.07e-04	10	86	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	8.07e-04	10	86	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	8.07e-04	10	86	2	GO:0102033
GeneOntologyMolecularFunction	actin binding	DSTN BAIAP2L1 CFL1 CFL2 CAMSAP3 MYH15 SORBS1 MYO16	1.07e-03	479	86	8	GO:0003779
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2F1 CYP4A11 CYP4A22	1.23e-03	49	86	3	GO:0016712
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4A11 CYP4A22	1.39e-03	13	86	2	GO:0016713
GeneOntologyMolecularFunction	monooxygenase activity	CYP2F1 CYP4A11 PTGIS CYP4A22	1.54e-03	115	86	4	GO:0004497
GeneOntologyMolecularFunction	arachidonate binding	CYP4A11 CYP4A22	1.86e-03	15	86	2	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4A11 CYP4A22	2.12e-03	16	86	2	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4A11 CYP4A22	2.12e-03	16	86	2	GO:0050543
GeneOntologyMolecularFunction	protein phosphatase binding	DRD1 CFL1 IRS2 YWHAE MYO16	2.14e-03	210	86	5	GO:0019903
GeneOntologyMolecularFunction	signaling adaptor activity	KHDRBS1 IRS2 SORBS1 YWHAE	2.35e-03	129	86	4	GO:0035591
GeneOntologyMolecularFunction	cadherin binding involved in cell-cell adhesion	BAIAP2L1 TRIM29	2.99e-03	19	86	2	GO:0098641
GeneOntologyBiologicalProcess	actin filament fragmentation	DSTN CFL1 CFL2	2.89e-07	4	87	3	GO:0030043
GeneOntologyBiologicalProcess	positive regulation of glycogen biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	8.64e-07	18	87	4	GO:0045725
GeneOntologyBiologicalProcess	positive regulation of glycogen metabolic process	IGF1 IRS2 SORBS1 DYRK2	2.94e-06	24	87	4	GO:0070875
GeneOntologyBiologicalProcess	regulation of glycogen biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	1.95e-05	38	87	4	GO:0005979
GeneOntologyBiologicalProcess	regulation of glucan biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	1.95e-05	38	87	4	GO:0010962
GeneOntologyBiologicalProcess	positive regulation of actin filament depolymerization	DSTN CFL1 CFL2	2.55e-05	14	87	3	GO:0030836
GeneOntologyBiologicalProcess	regulation of polysaccharide biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	4.59e-05	47	87	4	GO:0032885
GeneOntologyBiologicalProcess	lauric acid metabolic process	CYP4A11 CYP4A22	5.26e-05	3	87	2	GO:0048252
GeneOntologyBiologicalProcess	regulation of glycogen metabolic process	IGF1 IRS2 SORBS1 DYRK2	5.41e-05	49	87	4	GO:0070873
GeneOntologyBiologicalProcess	actin filament severing	DSTN CFL1 CFL2	5.65e-05	18	87	3	GO:0051014
GeneOntologyBiologicalProcess	D-glucose import	DRD1 IGF1 HK2 IRS2 SORBS1	7.18e-05	102	87	5	GO:0046323
GeneOntologyBiologicalProcess	regulation of protein depolymerization	DSTN CFL1 CFL2 CAMSAP3 APC	8.24e-05	105	87	5	GO:1901879
GeneOntologyBiologicalProcess	glucan biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	8.55e-05	55	87	4	GO:0009250
GeneOntologyBiologicalProcess	glycogen biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	8.55e-05	55	87	4	GO:0005978
GeneOntologyBiologicalProcess	positive regulation of protein depolymerization	DSTN CFL1 CFL2	9.12e-05	21	87	3	GO:1901881
GeneOntologyBiologicalProcess	regulation of polysaccharide metabolic process	IGF1 IRS2 SORBS1 DYRK2	1.05e-04	58	87	4	GO:0032881
GeneOntologyBiologicalProcess	positive regulation of glucose metabolic process	IGF1 IRS2 SORBS1 DYRK2	1.55e-04	64	87	4	GO:0010907
GeneOntologyBiologicalProcess	positive regulation of supramolecular fiber organization	DSTN BAIAP2L1 RB1 CFL1 CFL2 APC	1.82e-04	196	87	6	GO:1902905
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP2F1 CYP4A11 PTGIS CYP4A22	1.96e-04	68	87	4	GO:0019369
GeneOntologyBiologicalProcess	polysaccharide biosynthetic process	IGF1 IRS2 SORBS1 DYRK2	3.01e-04	76	87	4	GO:0000271
GeneOntologyBiologicalProcess	protein depolymerization	DSTN CFL1 CFL2 CAMSAP3 APC	3.61e-04	144	87	5	GO:0051261
GeneOntologyBiologicalProcess	regulation of protein-containing complex disassembly	DSTN CFL1 CFL2 CAMSAP3 APC	3.61e-04	144	87	5	GO:0043244
GeneOntologyBiologicalProcess	regulation of D-glucose import	IGF1 HK2 IRS2 SORBS1	3.84e-04	81	87	4	GO:0046324
GeneOntologyBiologicalProcess	D-glucose transmembrane transport	DRD1 IGF1 HK2 IRS2 SORBS1	4.09e-04	148	87	5	GO:1904659
GeneOntologyBiologicalProcess	hexose transmembrane transport	DRD1 IGF1 HK2 IRS2 SORBS1	4.49e-04	151	87	5	GO:0008645
GeneOntologyBiologicalProcess	negative regulation of epithelial cell apoptotic process	IGF1 GCM2 RB1 APC	4.82e-04	86	87	4	GO:1904036
GeneOntologyBiologicalProcess	positive regulation of type B pancreatic cell proliferation	IGF1 IRS2	4.84e-04	8	87	2	GO:1904692
GeneOntologyBiologicalProcess	monosaccharide transmembrane transport	DRD1 IGF1 HK2 IRS2 SORBS1	4.91e-04	154	87	5	GO:0015749
MousePheno	lethality during fetal growth through weaning, incomplete penetrance	DRD1 TUT4 IGF1 GCM2 KHDRBS1 RB1 CFL1 CAMSAP3 EHMT1 APC KMT2A SERPINC1 TSHZ1 ASXL2 YWHAE RAI1 TP73 BAHCC1	8.84e-06	1124	71	18	MP:0011112
Domain	ADF/Cofilin	DSTN CFL1 CFL2	9.43e-08	3	86	3	IPR017904
Domain	ADF	DSTN CFL1 CFL2	1.11e-05	10	86	3	SM00102
Domain	Cofilin_ADF	DSTN CFL1 CFL2	1.11e-05	10	86	3	PF00241
Domain	ADF_H	DSTN CFL1 CFL2	1.11e-05	10	86	3	PS51263
Domain	ADF-H	DSTN CFL1 CFL2	1.11e-05	10	86	3	IPR002108
Domain	Teashirt_fam	TSHZ3 TSHZ1	6.27e-05	3	86	2	IPR027008
Domain	CYTOCHROME_P450	CYP2F1 CYP4A11 PTGIS CYP4A22	1.37e-04	57	86	4	PS00086
Domain	-	CYP2F1 CYP4A11 PTGIS CYP4A22	1.47e-04	58	86	4	1.10.630.10
Domain	p450	CYP2F1 CYP4A11 PTGIS CYP4A22	1.47e-04	58	86	4	PF00067
Domain	Cyt_P450	CYP2F1 CYP4A11 PTGIS CYP4A22	1.68e-04	60	86	4	IPR001128
Domain	ADF-H/Gelsolin-like_dom	DSTN CFL1 CFL2	1.78e-04	24	86	3	IPR029006
Domain	-	DSTN CFL1 CFL2	1.78e-04	24	86	3	3.40.20.10
Domain	Cyt_P450_E_grp-I	CYP2F1 CYP4A11 CYP4A22	1.16e-03	45	86	3	IPR002401
Domain	SSD	DISP2 DISP1	1.58e-03	13	86	2	IPR000731
Domain	SSD	DISP2 DISP1	1.58e-03	13	86	2	PS50156
Domain	Cyt_P450_CS	CYP2F1 CYP4A11 CYP4A22	1.87e-03	53	86	3	IPR017972
Domain	EPHD	KMT2A RAI1	4.56e-03	22	86	2	PS51805
Domain	-	COL6A3 HMCN1 VWA5B1	4.83e-03	74	86	3	3.40.50.410
Domain	VWFA	COL6A3 HMCN1 VWA5B1	6.42e-03	82	86	3	PS50234
Domain	VWA	COL6A3 HMCN1 VWA5B1	6.87e-03	84	86	3	SM00327
Pathway	REACTOME_EICOSANOIDS	CYP4A11 PTGIS CYP4A22	2.29e-05	12	68	3	M27129
Pathway	REACTOME_EICOSANOIDS	CYP4A11 PTGIS CYP4A22	2.29e-05	12	68	3	MM14845
Pathway	REACTOME_FATTY_ACIDS	CYP2F1 CYP4A11 CYP4A22	4.69e-05	15	68	3	M27126
Pathway	REACTOME_FATTY_ACIDS	CYP2F1 CYP4A11 CYP4A22	8.32e-05	18	68	3	MM14841
Pubmed	The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics.	DSTN CFL1 CFL2	1.51e-08	3	87	3	11809832
Pubmed	TIRF microscopy analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover.	DSTN CFL1 CFL2	1.51e-08	3	87	3	26996939
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	VPS13D BAIAP2L1 EXPH5 MATK MINK1 CAMSAP3 APC KMT2A HELZ IRS2 SORBS1 MDM4 YWHAE DYRK2	2.97e-08	861	87	14	36931259
Pubmed	ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS.	DSTN CFL1 CFL2	6.04e-08	4	87	3	31400829
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E DSTN CFL1 MINK1 CAMSAP3 EHMT1 TPPP APC TJAP1 SORBS1 YWHAE TOP3B RCOR2 RAI1	1.18e-07	963	87	14	28671696
Pubmed	N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex.	DSTN CFL1 MKI67	1.51e-07	5	87	3	17875668
Pubmed	Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.	RB1 MKI67 MDM4	3.01e-07	6	87	3	25263199
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	FLT1 VPS13D EXPH5 RRP12 CAMSAP3 KMT2A IRS2 SORBS1 TOP3B RAI1	4.86e-07	497	87	10	36774506
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PCF11 MATK RRP12 MINK1 CAMSAP3 MKI67 KMT2A PACS2 TJAP1 BUD13 HELZ IRS2	5.23e-07	774	87	12	15302935
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	VPS13D RRP12 SORBS1 CADPS2 MYO16 BAHCC1	9.57e-07	130	87	6	12421765
Pubmed	ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.	DSTN CFL1 CFL2	1.79e-06	10	87	3	23259946
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PCF11 SMG1 CACNA1E KHDRBS1 CFL1 CFL2 CAMSAP3 MANF KMT2A MYH15 CADPS2 TOP3B RAI1 NUP35 BAHCC1	2.72e-06	1442	87	15	35575683
Pubmed	Peli1 Modulates the Subcellular Localization and Activity of Mdmx.	MDM4 YWHAE TP73	3.27e-06	12	87	3	29523541
Pubmed	p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.	MKI67 MDM4 TP73	3.27e-06	12	87	3	26527653
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	KHDRBS1 EXPH5 ARFGAP3 MKI67 APC HELZ YWHAE	4.56e-06	263	87	7	34702444
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP2F1 CYP4A11 PTGIS CYP4A22	4.59e-06	44	87	4	12745259
Pubmed	Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.	RB1 MKI67 TP73	5.39e-06	14	87	3	27001308
Pubmed	Malignant progressive tumor cell clone exhibits significant up-regulation of cofilin-2 and 27-kDa modified form of cofilin-1 compared to regressive clone.	CFL1 CFL2	6.19e-06	2	87	2	24023293
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	6.19e-06	2	87	2	15611369
Pubmed	Determining the differences in actin binding by human ADF and cofilin.	DSTN CFL1	6.19e-06	2	87	2	11812157
Pubmed	Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14.	CFL1 CFL2	6.19e-06	2	87	2	8800436
Pubmed	Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.	DISP2 DISP1	6.19e-06	2	87	2	10619433
Pubmed	IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.	IGF1 IRS2	6.19e-06	2	87	2	18717815
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	6.19e-06	2	87	2	23641057
Pubmed	Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α4β7 integrin antibody.	CFL1 CFL2	6.19e-06	2	87	2	30662943
Pubmed	Epithelial Src homology region 2 domain-containing phosphatase-1 restrains intestinal growth, secretory cell differentiation, and tumorigenesis.	PTPN6 APC	6.19e-06	2	87	2	28465325
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	6.19e-06	2	87	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	6.19e-06	2	87	2	24413902
Pubmed	Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.	FLT1 IGF1	6.19e-06	2	87	2	31755001
Pubmed	Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68.	KHDRBS1 APC	6.19e-06	2	87	2	22000517
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	6.19e-06	2	87	2	8031839
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	6.19e-06	2	87	2	10860550
Pubmed	Inactivation of conditional Rb by Villin-Cre leads to aggressive tumors outside the gastrointestinal tract.	RB1 APC	6.19e-06	2	87	2	16585182
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	6.19e-06	2	87	2	11320253
Pubmed	Proteomic profiling identifies an UV-induced activation of cofilin-1 and destrin in human epidermis.	DSTN CFL1	6.19e-06	2	87	2	15816841
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	6.19e-06	2	87	2	12464262
Pubmed	Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle.	CFL1 CFL2	6.19e-06	2	87	2	8195165
Pubmed	ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.	DSTN CFL1	6.19e-06	2	87	2	26655907
Pubmed	Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.	MKI67 APC	6.19e-06	2	87	2	33658388
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	6.19e-06	2	87	2	15066132
Pubmed	Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues.	CFL1 CFL2	6.19e-06	2	87	2	21894436
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	6.19e-06	2	87	2	23825080
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	6.19e-06	2	87	2	16691295
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	6.19e-06	2	87	2	3829886
Pubmed	Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.	MINK1 APC	6.19e-06	2	87	2	31160382
Pubmed	ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells.	DSTN CFL1	6.19e-06	2	87	2	34169836
Pubmed	N-cofilin can compensate for the loss of ADF in excitatory synapses.	DSTN CFL1	6.19e-06	2	87	2	22046357
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	6.19e-06	2	87	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	6.19e-06	2	87	2	21820496
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	6.19e-06	2	87	2	20943934
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	6.19e-06	2	87	2	2766933
Pubmed	Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the ApcMin model of colorectal cancer.	APC PACS2	6.19e-06	2	87	2	29312533
Pubmed	The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamics.	CFL1 CFL2	6.19e-06	2	87	2	8589446
Pubmed	Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array: evidence for a second binding site on monomeric actin.	DSTN CFL1	6.19e-06	2	87	2	17196218
Pubmed	Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor.	DSTN CFL1	6.19e-06	2	87	2	14627701
Pubmed	The ADF/cofilin family: actin-remodeling proteins.	CFL1 CFL2	6.19e-06	2	87	2	12049672
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	6.19e-06	2	87	2	17112342
Pubmed	Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells.	DSTN CFL1	6.19e-06	2	87	2	17583572
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	6.19e-06	2	87	2	30088983
Pubmed	Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.	TUT4 IGF1	6.19e-06	2	87	2	23209448
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	6.19e-06	2	87	2	19208908
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	TSHZ3 MKI67 EHMT1 KMT2A RAI1	6.29e-06	103	87	5	32744500
Pubmed	Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance.	DSTN CFL1 CFL2	6.73e-06	15	87	3	24598388
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	BAIAP2L1 CFL1 KIAA0586 KMT2A ASXL2 ALDOC RAI1	7.02e-06	281	87	7	24163370
Pubmed	Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina.	RB1 MDM4 TP73	8.27e-06	16	87	3	22714890
Pubmed	Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.	IGF1 CYP4A11 CYP4A22	8.27e-06	16	87	3	10087299
Pubmed	Loss of endogenous thymosin β4 accelerates glomerular disease.	DSTN CFL1 CFL2	1.20e-05	18	87	3	27575556
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DSTN KHDRBS1 CFL1 CFL2 MINK1 CAMSAP3 TPPP APC KMT2A PACS2 SORBS1 ALDOC YWHAE YARS1	1.22e-05	1431	87	14	37142655
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DSTN KHDRBS1 BAIAP2L1 EXPH5 CFL1 CFL2 RRP12 POLR2E MKI67 BUD13 TRIM29 YWHAE YARS1	1.44e-05	1257	87	13	36526897
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	TUT4 DSTN HK2 CFL1 EHMT1 APC KMT2A IRS2 MDM4 YWHAE	1.46e-05	730	87	10	34857952
Pubmed	Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.	RB1 TP73	1.85e-05	3	87	2	12761493
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	1.85e-05	3	87	2	2354437
Pubmed	KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.	RB1 MKI67	1.85e-05	3	87	2	34724040
Pubmed	The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein.	RB1 MDM4	1.85e-05	3	87	2	12532331
Pubmed	Dephosphorylation of serine 3 regulates nuclear translocation of cofilin.	CFL1 CFL2	1.85e-05	3	87	2	8824278
Pubmed	Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation.	DSTN CFL1	1.85e-05	3	87	2	26878213
Pubmed	Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.	DSTN CFL1	1.85e-05	3	87	2	26166299
Pubmed	Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in Apc+/- mice.	IGF1 APC	1.85e-05	3	87	2	20103605
Pubmed	Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.	DSTN CFL1	1.85e-05	3	87	2	15548599
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	1.85e-05	3	87	2	28270609
Pubmed	Biomarkers distinguishing mammary fibroepithelial neoplasms: a tissue microarray study.	RB1 MKI67	1.85e-05	3	87	2	25003838
Pubmed	Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation.	IRS2 YWHAE	1.85e-05	3	87	2	23615913
Pubmed	MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53.	MDM4 TP73	1.85e-05	3	87	2	34716260
Pubmed	Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.	PTPN6 IRS2	1.85e-05	3	87	2	12198247
Pubmed	Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma.	RB1 TP73	1.85e-05	3	87	2	20336668
Pubmed	Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB).	IGF1 RB1	1.85e-05	3	87	2	18697743
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	1.85e-05	3	87	2	37659685
Pubmed	Effects of MdmX on Mdm2-mediated downregulation of pRB.	RB1 MDM4	1.85e-05	3	87	2	16510145
Pubmed	Hedgehog signaling pathway and gastric cancer.	DISP2 DISP1	1.85e-05	3	87	2	16258256
Pubmed	HIV-1 Nef interferes with host cell motility by deregulation of Cofilin.	CFL1 CFL2	1.85e-05	3	87	2	19683683
Pubmed	Expression of the proliferating cell nuclear antigen and protein products of tumour suppressor genes in the human foetal testis.	RB1 APC	1.85e-05	3	87	2	14871261
Pubmed	Expression of pRb, Ki67 and HER 2/neu in gastric carcinomas: Relation to different histopathological grades and stages.	RB1 MKI67	1.85e-05	3	87	2	28965621
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	1.85e-05	3	87	2	9271096
Pubmed	Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development.	TSHZ3 TSHZ1	1.85e-05	3	87	2	16631416
Pubmed	Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.	DSTN CFL1	1.85e-05	3	87	2	24768258
Pubmed	ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing.	DSTN CFL1	1.85e-05	3	87	2	20530287
Pubmed	Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival.	IGF1 IRS2	1.85e-05	3	87	2	17636024
Pubmed	Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.	TSHZ3 TSHZ1	1.85e-05	3	87	2	19745106
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	1.85e-05	3	87	2	8011168
Pubmed	MDM2 and MDMX bind and stabilize the p53-related protein p73.	MDM4 TP73	1.85e-05	3	87	2	10469568
Interaction	ARHGEF4 interactions	KHDRBS1 APC YWHAE TOP3B NUP35	6.57e-06	61	87	5	int:ARHGEF4
Cytoband	Ensembl 112 genes in cytogenetic band chr1q25	CACNA1E HMCN1 SERPINC1 RGS16	2.97e-04	167	87	4	chr1q25
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 TSHZ1	9.30e-04	15	55	2	529
GeneFamily	Protein phosphatase catalytic subunits\|STRIPAK complex	MINK1 STRIP2	1.67e-03	20	55	2	1371
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CAMSAP3 MKI67 APC MYO16	2.23e-03	181	55	4	694
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EHMT1 KMT2A	4.79e-03	34	55	2	487
GeneFamily	Cytochrome P450 family 4	CYP4A11 CYP4A22	5.36e-03	36	55	2	1003
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	PCF11 SMG1 PTPN6 TUT4 SLF1 STYX KHDRBS1 CFL1 MATK KMT2A HELZ ASXL2 MDM4 MOB3A RGS16 USP20 DYRK2	7.00e-06	1492	87	17	M40023
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#2_top-relative-expression-ranked_1000	COL6A3 TSHZ3 IGF1 DCAF17 CADPS2 RGS16	2.13e-05	142	84	6	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k2
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_1000	COL6A3 TSHZ3 TUT4 IGF1 SLF1 STYX KHDRBS1 CFL2 APC SORBS1 ASXL2 CADPS2	5.01e-05	772	84	12	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_1000	SMG1 COL6A3 TSHZ3 TUT4 IGF1 HMCN1 DCAF17 TSHZ1 CADPS2 PTGIS RGS16 ZNF286A	6.33e-05	791	84	12	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	VPS13D CFL2 MINK1 KIAA0586 TSHZ1 TOP3B ZNF286A	8.76e-08	188	87	7	2c4e791df69a9df29922f9117e5cac7787c129ce
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|390C / Donor, Lineage, Cell class and subclass (all cells)	VPS13D MINK1 KIAA0586 TSHZ1 TOP3B ZNF286A	1.76e-06	186	87	6	064b6047215597465bb51a8a1547ef5a226552f9
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	SMG1 VPS13D HMCN1 DCAF17 APC ASXL2	1.76e-06	186	87	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VPS13D CFL2 MINK1 KIAA0586 TOP3B ZNF286A	1.87e-06	188	87	6	b1ec7c45aedcc3d22cac898c6a3679e7f8b44c77
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	SMG1 TUT4 SLF1 KMT2A MDM4	1.18e-05	151	87	5	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL6A3 IGF1 ALDOC ST18 RGS16	1.61e-05	161	87	5	be77e99faf653480c166305df3a4e93db76f0dcb
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL6A3 IGF1 ALDOC ST18 RGS16	1.81e-05	165	87	5	c6b23013d77fa9aa967b76e451c8e42b0a657c30
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 MATK SERPINC1 ALDOC DYRK2	1.86e-05	166	87	5	a2ce44702a0cd5fa5872cac3302d3c451205feef
ToppCell	facs-Lung-Endomucin-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HK2 MATK SERPINC1 ALDOC DYRK2	1.86e-05	166	87	5	0f641302a6b71c4badaaf20f51162bfc2386b167
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 ADRA1D MATK ST18 STRIP2	2.09e-05	170	87	5	c638dfde9ce30190abbe0caea1c3eb874af09857
ToppCell	COPD-Lymphoid-B_Plasma\|COPD / Disease state, Lineage and Cell class	IGF1 MANF EHMT1 CADPS2 TP73	2.53e-05	177	87	5	1b872d3b1e0fca138362098590a634d748dfca60
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 HMCN1 KIAA0586 TPPP DISP2	2.53e-05	177	87	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	facs-Bladder-nan-18m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 BAIAP2L1 CYP2F1 CFL1 TRIM29	3.65e-05	191	87	5	b842647caf05d39f602de83c647d5c224715d19f
ToppCell	Mild-CD8+_T\|World / Disease group and Cell class	PTPN6 SLF1 MATK KMT2A USP20	3.93e-05	194	87	5	d64c2efb482bcdef9240977eae1023c4191286e7
ToppCell	Fibroblast-B_(Myofibroblast)\|World / shred on cell class and cell subclass (v4)	COL6A3 IGF1 HMCN1 PTGIS RGS16	4.02e-05	195	87	5	a8d6416518f226e1ec2d6bdc9d4b90cef5cb1365
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ3 HMCN1 SORBS1 PTGIS	4.12e-05	196	87	5	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ3 HMCN1 SORBS1 PTGIS	4.12e-05	196	87	5	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	P03-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IGF1 HMCN1 TSHZ1 PTGIS RGS16	4.22e-05	197	87	5	2cec938caf6ffd031cea37277071487e59b2c71c
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	DSTN CFL1 CFL2 SORBS1 PTGIS	4.22e-05	197	87	5	4e0c3ea4f4a04a41532806edf3bccf7845c86fa5
ToppCell	(2)_Fibroblasts-(24)_Fibro-5\|(2)_Fibroblasts / Cell class and subclass of bone marrow stroma cells in homeostatis	COL6A3 IGF1 DSTN PPFIBP2 TSHZ1	4.22e-05	197	87	5	83a4b79fbfa1cf63441dee4424c3b87c988287bf
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_IV-2\|World / Primary Cells by Cluster	CACNA1E TSHZ3 SLF1 APC MYO16	4.43e-05	199	87	5	f09b40245d3d826275bbe5f508dedccc75a911bd
ToppCell	Sigmoid\|World / shred on region, Cell_type, and subtype	IGF1 DSTN ARFGAP3 MANF YWHAE	4.43e-05	199	87	5	83737cf4e511e660ec2d268447228cefc8a7ba9c
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_IV\|World / Primary Cells by Cluster	CACNA1E TSHZ3 SLF1 APC MYO16	4.43e-05	199	87	5	e45448ec4db8875c8aaa9aad109a10e2905a4226
ToppCell	COVID-19_Severe-PLT_5\|World / Disease Group and Platelet Clusters	BTBD6 DSTN CFL1 POLR2E MANF	4.43e-05	199	87	5	937e4028f896bc6b751182517611825d6716c682
ToppCell	Sigmoid\|World / Region, Cell class and subclass	IGF1 DSTN ARFGAP3 MANF YWHAE	4.43e-05	199	87	5	5b05ba8d24b33e88800777cf2cb0d5a6c8eea1d7
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FLT1 TUT4 SLF1 HMCN1 KMT2A	4.54e-05	200	87	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	PTPN6 HK2 BAIAP2L1 CAMSAP3 MKI67	4.54e-05	200	87	5	e3ad8d592686a5d1e1fb8dd05c2f00eac4c5738f
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	FLT1 SLF1 CFL2 KMT2A DISP1	4.54e-05	200	87	5	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FLT1 EXPH5 ST18 VWA5B1 RGS16	4.54e-05	200	87	5	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FLT1 EXPH5 ST18 VWA5B1 RGS16	4.54e-05	200	87	5	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	TCGA-Endometrium-Primary_Tumor\|TCGA-Endometrium / Sample_Type by Project: Shred V9	PTPN6 HK2 BAIAP2L1 CAMSAP3 MKI67	4.54e-05	200	87	5	1cbb62df4ea1631fef8497e1702175605d0869e7
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Neuron\|2m / Sample Type, Dataset, Time_group, and Cell type.	KHDRBS1 CFL1 ST18 RCOR2 RGS16	4.54e-05	200	87	5	a581f1704a87b0390e1e2ff85053367d85247755
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IGF1 CADPS2 ALDOC STRIP2	9.63e-05	122	87	4	1720756e0b3e8db14a9ccabe83f9b41689a4f754
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IGF1 CADPS2 RGS16 STRIP2	1.34e-04	133	87	4	840e8240db29cd21ed9830843c0fa6d65b8f300a
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRD1 MATK ST18 STRIP2	2.30e-04	153	87	4	3b1b0cc8e9dd2b1484649789330713282ee44414
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	COL6A3 IGF1 ALDOC RGS16	2.47e-04	156	87	4	896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1D CFL1 CADPS2 ALDOC	2.54e-04	157	87	4	921805932f7974d37aed547861d555b07f30aba6
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN6 HK2 STYX MKI67	2.54e-04	157	87	4	eea53cf8d8a607264e1ee00b7a97c94bcf2ac80d
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	HK2 BAIAP2L1 RRP12 STRIP2	2.66e-04	159	87	4	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 HK2 RCOR2 RGS16	2.79e-04	161	87	4	a7e09cf2ca6cd70d40d08440fe9c5ab9befa1b79
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 HK2 RCOR2 RGS16	2.79e-04	161	87	4	08920a716f6ec62538e361211455a30ad726d7be
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1D EXPH5 TSHZ1 CADPS2	2.92e-04	163	87	4	1e8ab00ecc2d2ba35aa6745c0ed38663e26312e8
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1D EXPH5 TSHZ1 CADPS2	2.92e-04	163	87	4	431221a41d396b09170476179590eaf8a55266d8
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HK2 TSHZ1 ST18 RCOR2	2.92e-04	163	87	4	99cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HK2 TSHZ1 ST18 RCOR2	2.92e-04	163	87	4	510c0af66e82c5a8cf8edd0547dae4018a87dbbf
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLF1 RRP12 MDM4 VWA5B1	2.92e-04	163	87	4	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	10x5'-bone_marrow-Lymphocytic_B_plasma-Plasmablasts\|bone_marrow / Manually curated celltypes from each tissue	IGF1 MKI67 MANF TP73	2.99e-04	164	87	4	67260e9f569f0acaeb0e65f69cde230f91cd3d26
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_TNFAIP8L3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1D IGF1 MKI67 VWA5B1	3.06e-04	165	87	4	cd73bba51f3f4871533c3512bdc0a1f05716344b
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	TSHZ3 CFL2 SORBS1 PTGIS	3.28e-04	168	87	4	a97e8e07ba949b30805aeed5f60fa5e092b9d3d4
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|World / disease group, cell group and cell class (v2)	PPFIBP2 ALDOC RGS16 USP20	3.35e-04	169	87	4	2bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCell	367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 IGF1 DSTN PTGIS	3.35e-04	169	87	4	47fd4adfe54777e69a0fabf8bd34f26223f63275
ToppCell	367C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 IGF1 DSTN PTGIS	3.35e-04	169	87	4	e09259d62cd3e42f0919f231ed1164db59b0b6c3
ToppCell	3'_v3-Lung-Lymphocytic_B_plasma\|Lung / Manually curated celltypes from each tissue	IGF1 MKI67 MANF TP73	3.35e-04	169	87	4	a65853ff9f6489cc1617cbba0d03b392d23c1528
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	EXPH5 MATK IRS2 DISP1	3.43e-04	170	87	4	f0b0d2d0402de3ed7322284a599646db43475761
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	EXPH5 MATK IRS2 DISP1	3.43e-04	170	87	4	054360a3b05f5e41221c98b122d241b1affad26a
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 MATK ST18 STRIP2	3.43e-04	170	87	4	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium\|TCGA-Endometrium / Sample_Type by Project: Shred V9	TSHZ3 CFL2 SORBS1 PTGIS	3.43e-04	170	87	4	cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal\|TCGA-Endometrium / Sample_Type by Project: Shred V9	TSHZ3 CFL2 SORBS1 PTGIS	3.43e-04	170	87	4	0bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue\|TCGA-Endometrium / Sample_Type by Project: Shred V9	TSHZ3 CFL2 SORBS1 PTGIS	3.43e-04	170	87	4	516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 MKI67 MYH15 DISP2	3.51e-04	171	87	4	b0373ed8283ee1792b6a490bff93906546978593
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	PPFIBP2 ALDOC RGS16 USP20	3.51e-04	171	87	4	78491478ba65bad45238fe114f5251b2adea323d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 MKI67 MYH15 DISP2	3.51e-04	171	87	4	b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell	droplet-Liver-Npc-18m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFL1 MATK MOB3A PTGIS	3.51e-04	171	87	4	e9c42ce444d42cbb4f97e81393756531bfe61637
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 MATK ST18 STRIP2	3.66e-04	173	87	4	f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DRD1 DSTN CFL2 PTGIS	3.66e-04	173	87	4	ecbf7167d4bec685e3460d826318544946f5f5c2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DRD1 DSTN CFL2 PTGIS	3.66e-04	173	87	4	b8dc978c52de64afba21ff6cb32e79f07167448e
ToppCell	facs-Marrow-T_cells-18m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGAP3 MANF IRS2 TP73	3.75e-04	174	87	4	3b1ee39e85e5f0d6b17fb3051dbfae66cb2be6ee
ToppCell	10x5'-bone_marrow-Lymphocytic_B_plasma\|bone_marrow / Manually curated celltypes from each tissue	IGF1 MANF CADPS2 TP73	3.75e-04	174	87	4	b1931028cf80af5eff6da15d7f0196205f17926f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL6A3 TSHZ3 ADRA1D PTGIS	3.83e-04	175	87	4	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT1 EXPH5 VWA5B1 RGS16	3.83e-04	175	87	4	9d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_GRIP2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADRA1D IGF1 MYO16 RGS16	3.83e-04	175	87	4	0c648e7f67ffbe3b476a2ca77d246554f8cd1882
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 MATK ST18 STRIP2	3.83e-04	175	87	4	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 CYP2F1 MATK CFAP61	3.91e-04	176	87	4	6b06da40eb97ea2db09f3a769494738b3e5fe3fa
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT1 EXPH5 ST18 RGS16	4.00e-04	177	87	4	84116796ca4c7007508c0f1a68a1135c7b922278
ToppCell	facs-Thymus-Epithelium-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BAIAP2L1 PPFIBP2 TPPP IRS2	4.00e-04	177	87	4	c2b8a3a149d70f77612759dea34df9e43953c566
ToppCell	facs-Thymus-Epithelium-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BAIAP2L1 PPFIBP2 TPPP IRS2	4.00e-04	177	87	4	384f841aa7b2d05815af7885e481f5affc55d897
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DSTN CFL2 MYH15 SORBS1	4.00e-04	177	87	4	88403b055eb9fdf96e4695fb6e0d78179e30a1e3
ToppCell	facs-Thymus-Epithelium-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BAIAP2L1 PPFIBP2 TPPP IRS2	4.00e-04	177	87	4	0e9e44119653abfd270e602e5e477a15e774638f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DSTN CFL2 MYH15 SORBS1	4.00e-04	177	87	4	8903aeaab61abd81a148ea623038c5114b8a183b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT1 EXPH5 VWA5B1 RGS16	4.08e-04	178	87	4	2a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	COL6A3 CYP2F1 IRS2 RGS16	4.08e-04	178	87	4	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 MATK ST18 STRIP2	4.08e-04	178	87	4	09a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IGF1 ALDOC VWA5B1 RGS16	4.17e-04	179	87	4	cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCell	COPD-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	FLT1 SORBS1 CADPS2 PTGIS	4.17e-04	179	87	4	9968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E PRR14L RCOR2 DYRK2	4.17e-04	179	87	4	69c74b2ff43b43653005807654953daf21f932ec
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	CFL1 ST18 RGS16 STRIP2	4.17e-04	179	87	4	d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell	3'_v3-blood-Lymphocytic_B_plasma-Plasmablasts\|blood / Manually curated celltypes from each tissue	IGF1 MKI67 MANF TP73	4.17e-04	179	87	4	7d3bd1f9e126a4a9e0a84720a6cc0b3d235e65ee
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HK2 BAIAP2L1 EXPH5 DISP2	4.17e-04	179	87	4	c833ded1f9e87be2ba2037820d92a389560b711c
ToppCell	TCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1\|TCGA-Adrenal / Sample_Type by Project: Shred V9	DISP2 SORBS1 PTGIS RGS16	4.17e-04	179	87	4	431e1b29015ec817f778499106d24b19cfc825ae
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E CYP4A11 ST18 CYP4A22	4.17e-04	179	87	4	78fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 DRD1 IGF1 TJAP1	4.35e-04	181	87	4	41969fe4d94ee77b12ecde32170aaf0b13e49644
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDOC USP20 ZNF286A DYRK2	4.35e-04	181	87	4	e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 DRD1 IGF1 TJAP1	4.35e-04	181	87	4	3f50e61dc2a52d71a5801584617607e6246adcf2
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT1 EXPH5 ST18 RGS16	4.35e-04	181	87	4	062f00736eed96e4f4327615d093558dd7d82b20
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDOC USP20 ZNF286A DYRK2	4.35e-04	181	87	4	d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DSTN IRS2 SORBS1 TRIM29	4.44e-04	182	87	4	37547b36264090b49a193a8ef3a8d88e647f0b79
ToppCell	COPD-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	IGF1 MANF CADPS2 TP73	4.44e-04	182	87	4	19db653fe04c5e2957eea1f4893b1c1fca4ddcbd
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A3 FLT1 IGF1 PTGIS	4.44e-04	182	87	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A3 IGF1 PTGIS RCOR2	4.53e-04	183	87	4	06a68fa2be36448064f4668be24a5b85ad85c6e8
ToppCell	368C-Lymphocytic-Plasma_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IGF1 MANF EHMT1 CADPS2	4.53e-04	183	87	4	7733cf919eda146efe41c93990658ce92db73aa8
Drug	Butirosin disulfate salt [51022-98-1]; Down 200; 5.4uM; MCF7; HT_HG-U133A	PTPN6 ADRA1D VPS13D RB1 RRP12 EHMT1 APC MDM4	7.91e-07	194	87	8	6779_DN
Disease	adenoma (is_implicated_in)	APC TP73	8.01e-06	2	84	2	DOID:657 (is_implicated_in)
Disease	nemaline myopathy 7 (implicated_via_orthology)	DSTN CFL1	8.01e-06	2	84	2	DOID:0110934 (implicated_via_orthology)
Disease	Retinoblastoma	RB1 MDM4	2.40e-05	3	84	2	C0035335
Disease	antiphospholipid antibody measurement	CACNA1E DSTN MYO16	4.89e-05	25	84	3	EFO_0005200
Disease	Bladder Neoplasm	IGF1 RB1 KMT2A ASXL2 MDM4	5.11e-05	140	84	5	C0005695
Disease	Malignant neoplasm of breast	FLT1 IGF1 RB1 ARFGAP3 CFL1 CFL2 MKI67 EHMT1 SORBS1 TRIM29 MDM4 TP73	5.14e-05	1074	84	12	C0006142
Disease	Malignant neoplasm of urinary bladder	IGF1 RB1 KMT2A ASXL2 MDM4	5.29e-05	141	84	5	C0005684
Disease	X-14939 measurement	CYP4A11 CYP4A22	1.19e-04	6	84	2	EFO_0800747
Disease	Acute erythroleukemia - M6a subtype	RB1 KMT2A	2.22e-04	8	84	2	C2930975
Disease	Acute myeloid leukemia FAB-M6	RB1 KMT2A	2.22e-04	8	84	2	C2930976
Disease	Acute erythroleukemia - M6b subtype	RB1 KMT2A	2.22e-04	8	84	2	C2930977
Disease	Acute erythroleukemia	RB1 KMT2A	2.22e-04	8	84	2	C2930974
Disease	Childhood Medulloblastoma	EHMT1 APC IRS2	2.53e-04	43	84	3	C0278510
Disease	Melanotic medulloblastoma	EHMT1 APC IRS2	2.53e-04	43	84	3	C1275668
Disease	Medullomyoblastoma	EHMT1 APC IRS2	2.53e-04	43	84	3	C0205833
Disease	Desmoplastic Medulloblastoma	EHMT1 APC IRS2	2.53e-04	43	84	3	C0751291
Disease	Adult Medulloblastoma	EHMT1 APC IRS2	2.53e-04	43	84	3	C0278876
Disease	psoriasis (is_marker_for)	FLT1 IGF1 MKI67	2.71e-04	44	84	3	DOID:8893 (is_marker_for)
Disease	pancreatic cancer (is_implicated_in)	IGF1 MKI67 MANF APC	3.00e-04	112	84	4	DOID:1793 (is_implicated_in)
Disease	Gastrointestinal Stromal Sarcoma	RB1 DISP1 DYRK2	3.30e-04	47	84	3	C3179349
Disease	Neoplasm Metastasis	FLT1 IGF1 RB1 CFL1 YWHAE	3.96e-04	217	84	5	C0027627
Disease	Medulloblastoma	EHMT1 APC IRS2	3.96e-04	50	84	3	C0025149
Disease	Gastrointestinal Stromal Tumors	RB1 DISP1 DYRK2	3.96e-04	50	84	3	C0238198
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	4.33e-04	11	84	2	DOID:0110861 (biomarker_via_orthology)
Disease	Small cell carcinoma of lung	RB1 KMT2A TP73	4.97e-04	54	84	3	C0149925
Disease	retinopathy of prematurity (biomarker_via_orthology)	FLT1 IGF1	5.19e-04	12	84	2	DOID:13025 (biomarker_via_orthology)
Disease	reaction time measurement	ADRA1D TPPP APC MYH15 TSHZ1 YWHAE RGS16 RAI1	5.76e-04	658	84	8	EFO_0008393
Disease	breast cancer (biomarker_via_orthology)	FLT1 IGF1	6.12e-04	13	84	2	DOID:1612 (biomarker_via_orthology)
Disease	Liver carcinoma	IGF1 RB1 CYP4A11 MKI67 APC KMT2A IRS2	6.15e-04	507	84	7	C2239176
Disease	vascular dementia (biomarker_via_orthology)	FLT1 IGF1	7.13e-04	14	84	2	DOID:8725 (biomarker_via_orthology)
Disease	Kuhnt-Junius degeneration (is_marker_for)	FLT1 IGF1	7.13e-04	14	84	2	DOID:10873 (is_marker_for)
Disease	Mammary Carcinoma, Human	FLT1 IGF1 RB1 CFL1 MKI67 MDM4 TP73	7.54e-04	525	84	7	C4704874
Disease	Mammary Neoplasms, Human	FLT1 IGF1 RB1 CFL1 MKI67 MDM4 TP73	7.54e-04	525	84	7	C1257931
Disease	Mammary Neoplasms	FLT1 IGF1 RB1 CFL1 MKI67 MDM4 TP73	7.71e-04	527	84	7	C1458155
Disease	Neoplasm of uncertain or unknown behavior of bladder	RB1 MDM4	8.21e-04	15	84	2	C0496930
Disease	Benign neoplasm of bladder	RB1 MDM4	8.21e-04	15	84	2	C0154017
Disease	Carcinoma in situ of bladder	RB1 MDM4	8.21e-04	15	84	2	C0154091
Disease	Alzheimer's disease (is_marker_for)	DRD1 IGF1 APC IRS2 MDM4	8.50e-04	257	84	5	DOID:10652 (is_marker_for)
Disease	Breast Carcinoma	FLT1 IGF1 RB1 CFL1 MKI67 MDM4 TP73	8.70e-04	538	84	7	C0678222
Disease	Schizophrenia	PTPN6 DRD1 APC KMT2A CADPS2 YWHAE TOP3B MYO16 RAI1	9.16e-04	883	84	9	C0036341
Disease	renal cell carcinoma (is_implicated_in)	MANF APC TP73	1.02e-03	69	84	3	DOID:4450 (is_implicated_in)
Disease	Carcinoma of bladder	RB1 MDM4	1.19e-03	18	84	2	C0699885
Disease	intellectual disability (implicated_via_orthology)	RB1 IRS2 PUS7	1.30e-03	75	84	3	DOID:1059 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (is_implicated_in)	IGF1 HK2 IRS2 SORBS1	1.46e-03	171	84	4	DOID:9352 (is_implicated_in)
Disease	X-24309 measurement	ADRA1D CYP4A11	1.47e-03	20	84	2	EFO_0800872
Disease	Sarcoma	RB1 MDM4	1.62e-03	21	84	2	C1261473
Disease	in situ carcinoma (is_marker_for)	RB1 MKI67	1.62e-03	21	84	2	DOID:8719 (is_marker_for)
Disease	osteoporosis (biomarker_via_orthology)	IGF1 IRS2	1.78e-03	22	84	2	DOID:11476 (biomarker_via_orthology)
Disease	Dystonia	CACNA1E COL6A3 DCAF17	1.92e-03	86	84	3	C0013421
Disease	colorectal cancer, hormone replacement therapy	TUT4 DISP1 MYO16	2.05e-03	88	84	3	EFO_0003961, MONDO_0005575
Disease	nephrotic syndrome (biomarker_via_orthology)	CFL1 SERPINC1	2.12e-03	24	84	2	DOID:1184 (biomarker_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	ADRA1D DRD1 DSTN CFL1	2.36e-03	195	84	4	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PKSSYSDMETRPQSK	ZNF286A	106	Q9HBT8
AYKAASDIAMTELPP	YWHAE	151	P62258
SSVASEPRKLYEMPK	DCAF17	76	Q5H9S7
MAAAPPLSKAEYLKR	BUD13	1	Q9BRD0
PPDEVSAMKNLLKYS	BAHCC1	626	Q9P281
PSKAVSKDPMSYALN	CFAP61	636	Q8NHU2
PESAPLKSKMIYASS	CFL1	106	P23528
SPIMAKPRKKYNDDS	ARFGAP3	331	Q9NP61
PMPKASDLTVGKIYA	CACNA1E	1856	Q15878
SPSIRALYTKMVPAA	BSDC1	166	Q9NW68
MPHSYPALSAEQKKE	ALDOC	1	P09972
PAKMAAELYAPASAA	BTBD6	51	Q96KE9
DPDYMKVILGRSDPK	CYP4A11	101	Q02928
SSPFRYERKMTPKAA	DRD1	126	P21728
PMCIYRSPEKKATED	SERPINC1	51	P01008
PELAPLKSKMIYASS	DSTN	106	P60981
SKPLSDRPTKAPVYM	CAMSAP3	506	Q9P1Y5
FMTPKTADYATPALK	DISP1	436	Q96F81
PPEKSYAKLVFMSTS	DISP2	281	A7MBM2
AAKTVLEKYPNTPMS	ASXL2	16	Q76L83
TAADMYLSPVRSPKK	RB1	601	P06400
PESPARYSNKELKGM	RCOR2	61	Q8IZ40
YDENLMKKTAVPPSR	RAI1	141	Q7Z5J4
PLMAALPAYFAKSAT	OPN1LW	301	P04000
RLPALKDRAAMPYTD	CYP2F1	336	P24903
YRKLKCMTDSESAPP	MSANTD1	106	Q6ZTZ1
GRAPYPKMSLKEVSE	MATK	421	P42679
SVKDPSPLYDMLRKN	MDM4	91	O15151
ARPRPHSDDYSTMKK	MYO16	1331	Q9Y6X6
KFRKPTALSAPRYMD	MOB3A	106	Q96BX8
PESAPLKSKMIYASS	CFL2	106	Q9Y281
KETHASAPVKMLPTY	HK2	501	P52789
PLTYRLSKEMAKNDP	EXPH5	81	Q8NEV8
KAVGASFPLYEPAKM	MKI67	331	P46013
PIAEAMLTYKQKSPD	PACS2	651	Q86VP3
KPAMSYASALRAPPK	HELZ	1891	P42694
QEKREKMASPAYTPL	PPFIBP2	791	Q8ND30
ELMPKYAPKAASART	MANF	166	P55145
MTDKKYDLSVHAPPS	HMCN1	2371	Q96RW7
QTAKAPSSEKLPVMY	PCF11	61	O94913
PGTAIRAMPVYKKAE	TP73	171	O15350
SDYMNLDFSSPKSPK	IRS2	976	Q9Y4H2
RKDYDTLSKCSPKMP	BAIAP2L1	271	Q9UHR4
DPDYMKVILGRSDPK	CYP4A22	101	Q5TCH4
AVRKMKPLDGSALYT	COL6A3	511	P12111
AAKYVDVPKPGMDLA	CADPS2	1161	Q86UW7
ATASVKMEPENKYLP	KHDRBS1	91	Q07666
IKRSKSSIMYFEPAP	KMT2A	3286	Q03164
EMYCAPLKPAKSARS	IGF1	106	P05019
MLTRKPSAAAPAAYP	DYRK2	1	Q92630
SVVKYELMRPSNKAP	EHMT1	556	Q9H9B1
KRPNSKPMALYSLES	PRR14L	1681	Q5THK1
PRISTMRPLATAYKA	NUP35	281	Q8NFH5
DEAPRPPKKAMDYSS	MINK1	811	Q8N4C8
LKGYPSLMRSQSPKA	TRIM29	541	Q14134
LASAAYPDPSKQKPM	YARS1	336	P54577
TPSAKQSLVDMAPKY	POLR2E	111	P19388
VKSMRAASPPSYTLD	STRIP2	311	Q9ULQ0
PCMTYQPKATSLDRK	FER1L5	636	A0AVI2
QLPHYSPSDEKARMK	PTGIS	111	Q16647
VMAAYKGKRRSEAPP	MYH15	156	Q9Y2K3
PPAMKYSDSVREVKS	GCM2	396	O75603
LMKKSETYAPLFSLP	SMG1	741	Q96Q15
PPVFASEGKYRALKM	PUS7	611	Q96PZ0
PMQSAAKAPYLAKFK	PI4KAP2	261	A4QPH2
LFLGPYSSAMKSKLP	STYX	36	Q8WUJ0
RPVAKKAMPGAEYKA	RRP12	1221	Q5JTH9
SLLMKPRHYSPKADC	ST18	56	O60284
SLKYPAIMTERKAAA	ADRA1D	201	P25100
KYKDANIMSPGSSLP	APC	736	P25054
MTSAAPAKKPYRKAP	TJAP1	1	Q5JTD0
NPRRPKDKMSALAAY	TOP3B	846	O95985
KSPLSVPRSKSEMSY	SORBS1	471	Q9BX66
TLMEKDSYPRFLKSP	RGS16	161	O15492
KDSRYSPQMQSAPKR	SLF1	96	Q9BQI6
RASPVRMAPSYVLKK	USP20	411	Q9Y2K6
PSAKYMCPEKELARA	TSHZ3	41	Q63HK5
YPPAMKNAHAKASRT	PTPN6	541	P29350
MADKAKPAKAANRTP	TPPP	1	O94811
RQTPLSKLMKAYCEP	SUMO4	36	Q6EEV6
RSYRLSMKVKAFPSP	FLT1	351	P17948
SVHPSNLMEKKPSAY	ZNF382	256	Q96SR6
YQMKSEKVPSSPAEA	TUT4	146	Q5TAX3
KISNSMLDKPVYPAT	TSHZ1	776	Q6ZSZ6
SMPSSRAVEKYSVKP	KIAA0586	271	Q9BVV6
SDPMPAAKRYPLRKA	VWA5B1	676	Q5TIE3
PDSKYKNLMVSRGAP	VPS13D	1681	Q5THJ4