Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionAMP-activated protein kinase activity

PRKAA1 PRKAA2 PRKAG2

3.13e-05101303GO:0004679
GeneOntologyMolecularFunctionhistone H2BS36 kinase activity

PRKAA1 PRKAA2

4.21e-0521302GO:0140823
GeneOntologyMolecularFunction[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

PRKAA1 PRKAA2

4.21e-0521302GO:0047322
GeneOntologyMolecularFunctionhistone H2B kinase activity

PRKAA1 PRKAA2

4.21e-0521302GO:0140998
GeneOntologyMolecularFunctiontau-protein kinase activity

PRKAA1 MARK4 ROCK1

3.79e-04221303GO:0050321
GeneOntologyMolecularFunctionhistone H3K27me2/H3K27me3 demethylase activity

KDM6B KDM7A

4.15e-0451302GO:0071558
GeneOntologyMolecularFunctionprotein kinase activity

ERBB2 VRK3 CRIM1 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG PRKAG2

5.57e-0460013012GO:0004672
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG PRKAG2

6.86e-0444613010GO:0004674
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5D KDM6B KDM7A

7.84e-04281303GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5D KDM6B KDM7A

1.06e-03311303GO:0032452
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

MYC EBF3 GATA1 E2F3 RFX6 KLF4 HOXA9 NFATC2 GLIS1 NOTCH2 SMAD4

1.10e-0356013011GO:0001228
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5D KDM6B KDM7A

1.16e-03321303GO:0140457
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

MYC EBF3 GATA1 E2F3 RFX6 KLF4 HOXA9 NFATC2 GLIS1 NOTCH2 SMAD4

1.20e-0356613011GO:0001216
GeneOntologyBiologicalProcessneuron projection development

TANC2 ARHGAP32 ERBB2 FAT4 HECW1 SZT2 MYO9A SPIRE1 KLF4 CRMP1 TBC1D24 PTPRG NFATC4 PTPRZ1 DOCK7 ROCK1 TNXB PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4 SEZ6

1.45e-06128513024GO:0031175
GeneOntologyBiologicalProcessleft ventricular cardiac muscle tissue morphogenesis

KLK3 KLK2 SMAD4

8.41e-0671303GO:0003220
GeneOntologyBiologicalProcessepithelial cell differentiation

FNDC3B FAT4 RARA MYO9A NUMA1 GATA1 RFX6 KDM6B KLF4 WNT5B SCUBE1 F11R ROCK1 MARVELD2 PERCC1 PALLD NOTCH2 SMAD4

8.98e-0687013018GO:0030855
GeneOntologyBiologicalProcessmiRNA metabolic process

MYC RARA KLF4 AGO4 NFATC4 NOTCH2 SMAD4

1.05e-051191307GO:0010586
GeneOntologyBiologicalProcessneuron projection morphogenesis

TANC2 ARHGAP32 ERBB2 HECW1 SZT2 MYO9A TBC1D24 NFATC4 PTPRZ1 DOCK7 ROCK1 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

1.19e-0580213017GO:0048812
GeneOntologyBiologicalProcessneuron development

TANC2 ARHGAP32 ERBB2 FAT4 HECW1 SZT2 MYO9A SPIRE1 KLF4 CRMP1 TBC1D24 PTPRG NFATC4 PTPRZ1 DOCK7 ROCK1 TNXB PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4 SEZ6

1.33e-05146313024GO:0048666
GeneOntologyBiologicalProcessregulation of miRNA transcription

MYC RARA KLF4 NFATC4 NOTCH2 SMAD4

1.42e-05831306GO:1902893
GeneOntologyBiologicalProcessmiRNA transcription

MYC RARA KLF4 NFATC4 NOTCH2 SMAD4

1.52e-05841306GO:0061614
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

TANC2 ARHGAP32 ERBB2 HECW1 SZT2 MYO9A TBC1D24 NFATC4 PTPRZ1 DOCK7 ROCK1 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

1.56e-0581913017GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

TANC2 ARHGAP32 ERBB2 HECW1 SZT2 MYO9A TBC1D24 NFATC4 PTPRZ1 DOCK7 ROCK1 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

1.74e-0582613017GO:0048858
GeneOntologyBiologicalProcesstissue morphogenesis

MYC FAT4 RARA MYO9A KDM6B KLK3 KLF4 AHDC1 AXIN1 WNT5B ESRP2 NFATC4 CSMD1 KLK2 NOTCH2 SMAD4

2.04e-0575013016GO:0048729
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

ARHGAP32 ERBB2 RASA2 MYO9A ARHGAP30 KLK3 DENND4C F11R DOCK7 ROCK1 KLK2 NOTCH2 PLCE1

3.62e-0553813013GO:0007264
GeneOntologyBiologicalProcessepithelium development

MYC FNDC3B FAT4 RARA MYO9A NUMA1 GATA1 RFX6 KDM6B KLF4 WNT5B ESRP2 SCUBE1 F11R NFATC4 ROCK1 MARVELD2 CSMD1 PERCC1 PALLD PLXNA2 NOTCH2 SMAD4

4.30e-05146913023GO:0060429
GeneOntologyBiologicalProcessregulation of miRNA metabolic process

MYC RARA KLF4 NFATC4 NOTCH2 SMAD4

4.84e-051031306GO:2000628
GeneOntologyBiologicalProcessregulation of stress granule assembly

USP10 PRKAA1 PRKAA2

5.16e-05121303GO:0062028
GeneOntologyBiologicalProcessregulation of cell development

MYC ARHGAP32 ERBB2 RARA TMEM176B GATA1 TBC1D24 HOXA9 FBN1 F11R NFATC4 PTPRZ1 DOCK7 ROCK1 CCL23 PLXNA2 NOTCH2 PLXNB3 SMAD4

5.66e-05109513019GO:0060284
GeneOntologyBiologicalProcesscell fate commitment

RARA GATA1 KDM6B KLF4 WNT5B DOCK7 TNXB GLIS1 NOTCH2 SMAD4

5.73e-0533813010GO:0045165
GeneOntologyBiologicalProcesscell morphogenesis

TANC2 ARHGAP32 ERBB2 HECW1 SZT2 MYO9A GATA1 TBC1D24 AGO4 F11R NFATC4 PTPRZ1 DOCK7 ROCK1 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

5.78e-05119413020GO:0000902
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

TANC2 ARHGAP32 ERBB2 HECW1 SZT2 TBC1D24 NFATC4 PTPRZ1 DOCK7 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

7.56e-0574813015GO:0048667
GeneOntologyBiologicalProcessnegative regulation of developmental process

MYC FNDC3B ERBB2 RARA TMEM176B CRIM1 GATA1 KLK3 KLF4 AXIN1 HOXA9 FBN1 ADAMTS7 NFATC2 NFATC4 PTPRZ1 ROCK1 CCL23 GLIS1 SMAD4

7.77e-05122013020GO:0051093
GeneOntologyBiologicalProcesstissue kallikrein-kinin cascade

KLK3 KLK2

1.18e-0431302GO:0002255
GeneOntologyBiologicalProcessaxon development

ARHGAP32 ERBB2 SZT2 KLF4 TBC1D24 PTPRZ1 DOCK7 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

2.12e-0464213013GO:0061564
GeneOntologyBiologicalProcesskidney mesenchyme morphogenesis

MYC SMAD4

2.35e-0441302GO:0072131
GeneOntologyBiologicalProcessmetanephric mesenchyme morphogenesis

MYC SMAD4

2.35e-0441302GO:0072133
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

2.35e-0441302GO:0035583
GeneOntologyBiologicalProcessprotein localization to lipid droplet

PRKAA1 PRKAA2

2.35e-0441302GO:1990044
GeneOntologyBiologicalProcessbradykinin biosynthetic process

KLK3 KLK2

2.35e-0441302GO:0002936
GeneOntologyBiologicalProcessepithelial cell development

RARA GATA1 WNT5B F11R ROCK1 MARVELD2 PALLD NOTCH2

3.11e-042691308GO:0002064
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

ERBB2 CRMP1 PLXNA2 PLXNB3

3.23e-04521304GO:0071526
GeneOntologyBiologicalProcessregulation of cell projection organization

TANC2 ARHGAP32 HECW1 MYO9A KLF4 CRMP1 TBC1D24 PTPRG NFATC4 PTPRZ1 MARK4 PLXNA2 PLXNB3 SEZ6 PLCE1

3.57e-0486313015GO:0031344
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

MYC FNDC3B ERBB2 RARA TMEM176B CRIM1 AXIN1 HOXA9 FBN1 ADAMTS7 NFATC2 NFATC4 CCL23 GLIS1 SMAD4

4.13e-0487513015GO:0045596
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

MYC ERBB2 VRK3 GATA1 ANKLE2 AXIN1 FBN1 FBH1 PTPRZ1 PRKAA1 PRKAA2 DOCK7 ROCK1 PRKAG2 NOTCH2

4.33e-0487913015GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

MYC ERBB2 VRK3 GATA1 ANKLE2 AXIN1 FBN1 FBH1 PTPRZ1 PRKAA1 PRKAA2 DOCK7 ROCK1 PRKAG2 NOTCH2

4.33e-0487913015GO:0010562
GeneOntologyBiologicalProcessregulation of anatomical structure morphogenesis

TANC2 ARHGAP32 ERBB2 HECW1 MYO9A SPIRE1 KLK3 KLF4 TBC1D24 WNT5B AGO4 F11R NFATC4 PTPRZ1 ROCK1 PLXNA2 PLXNB3

4.98e-04109013017GO:0022603
GeneOntologyBiologicalProcessregulation of neuron projection development

TANC2 ARHGAP32 HECW1 KLF4 CRMP1 TBC1D24 PTPRG NFATC4 PTPRZ1 PLXNA2 PLXNB3 SEZ6

4.99e-0461213012GO:0010975
GeneOntologyBiologicalProcessendothelial cell differentiation

KDM6B SCUBE1 F11R ROCK1 MARVELD2 SMAD4

5.01e-041581306GO:0045446
GeneOntologyBiologicalProcesscardiac left ventricle morphogenesis

KLK3 KLK2 SMAD4

5.08e-04251303GO:0003214
GeneOntologyBiologicalProcesspositive regulation of neuron migration

ARHGAP32 TBC1D24 PTPRZ1

5.08e-04251303GO:2001224
GeneOntologyBiologicalProcessskeletal system development

MYC FAT4 RARA CR2 AXIN1 HOXA9 FBN1 FBN2 ADAMTS7 NFATC2 ANKRD11 NOTCH2

5.21e-0461513012GO:0001501
GeneOntologyBiologicalProcesskinin cascade

KLK3 KLK2

5.82e-0461302GO:0002254
GeneOntologyBiologicalProcesspositive regulation of miRNA transcription

MYC KLF4 NOTCH2 SMAD4

5.95e-04611304GO:1902895
GeneOntologyBiologicalProcessregulation of neuron migration

ARHGAP32 TBC1D24 PTPRZ1 UNC5D

6.33e-04621304GO:2001222
GeneOntologyBiologicalProcessregulation of nucleotide catabolic process

MYC PRKAA1 PRKAA2 PRKAG2

6.73e-04631304GO:0030811
GeneOntologyBiologicalProcessregulation of purine nucleotide catabolic process

MYC PRKAA1 PRKAA2 PRKAG2

6.73e-04631304GO:0033121
GeneOntologyBiologicalProcessregulation of glycolytic process

MYC PRKAA1 PRKAA2 PRKAG2

6.73e-04631304GO:0006110
GeneOntologyBiologicalProcesspeptidyl-serine phosphorylation

VRK3 AXIN1 SGK2 SGK3 PRKAA1 DOCK7 ROCK1 PRKCG

7.44e-043071308GO:0018105
GeneOntologyBiologicalProcessmale gonad development

RARA GATA1 HOXA9 AGO4 CSMD1 SMAD4

7.60e-041711306GO:0008584
GeneOntologyBiologicalProcessdevelopment of primary male sexual characteristics

RARA GATA1 HOXA9 AGO4 CSMD1 SMAD4

7.83e-041721306GO:0046546
GeneOntologyBiologicalProcesspositive regulation of glycolytic process

MYC PRKAA1 PRKAA2

7.93e-04291303GO:0045821
GeneOntologyBiologicalProcesspositive regulation of nucleotide catabolic process

MYC PRKAA1 PRKAA2

7.93e-04291303GO:0030813
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide catabolic process

MYC PRKAA1 PRKAA2

7.93e-04291303GO:0033123
GeneOntologyBiologicalProcesslipid droplet disassembly

PRKAA1 PRKAA2

8.11e-0471302GO:1905691
GeneOntologyBiologicalProcessnegative regulation of tubulin deacetylation

PRKAA1 PRKAA2

8.11e-0471302GO:1904428
GeneOntologyBiologicalProcesspositive regulation of peptidyl-lysine acetylation

PRKAA1 PRKAA2

8.11e-0471302GO:2000758
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

MYC FNDC3B ARHGAP32 RARA NUMA1 GATA1 TBC1D24 WNT5B FBN2 F11R PTPRZ1 CCL23 TNXB PLXNA2 NOTCH2 PLXNB3 SMAD4

8.31e-04114113017GO:0045597
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

TANC2 ARHGAP32 HECW1 KLF4 CRMP1 TBC1D24 PTPRG NFATC4 PTPRZ1 MARK4 PLXNA2 PLXNB3 SEZ6 PLCE1

9.12e-0484613014GO:0120035
GeneOntologyBiologicalProcessaxonogenesis

ARHGAP32 ERBB2 SZT2 PTPRZ1 DOCK7 PALLD UNC5D PLXNA2 NOTCH2 PLXNB3 SMAD4

9.23e-0456613011GO:0007409
GeneOntologyBiologicalProcesspeptidyl-serine modification

VRK3 AXIN1 SGK2 SGK3 PRKAA1 DOCK7 ROCK1 PRKCG

9.52e-043191308GO:0018209
GeneOntologyCellularComponentnucleotide-activated protein kinase complex

PRKAA1 PRKAA2 PRKAG2

3.91e-05111323GO:0031588
GeneOntologyCellularComponentsemaphorin receptor complex

ERBB2 PLXNA2 PLXNB3

6.72e-05131323GO:0002116
DomainIPT

EBF3 NFATC2 NFATC4 PLXNA2 PLXNB3

1.12e-06271315SM00429
DomainTIG

EBF3 NFATC2 NFATC4 PLXNA2 PLXNB3

2.31e-06311315PF01833
DomainIPT

EBF3 NFATC2 NFATC4 PLXNA2 PLXNB3

2.72e-06321315IPR002909
DomainIg_E-set

EBF3 TGM5 NFATC2 NFATC4 KCNJ14 PLXNA2 PLXNB3

8.58e-061041317IPR014756
DomainKA1/Ssp2_C

PRKAA1 PRKAA2 MARK4

1.16e-0571313IPR028375
DomainGrowth_fac_rcpt_

ERBB2 FAT4 CRIM1 SCUBE1 FBN1 FBN2 TNXB NOTCH2

1.44e-051561318IPR009030
DomainRho_GTPase_activation_prot

ARHGAP32 RASA2 MYO9A ARHGAP30 PLXNA2 PLXNB3

3.59e-05881316IPR008936
DomainAdenylateSensor

PRKAA1 PRKAA2

4.88e-0521312PF16579
DomainAMPK_C

PRKAA1 PRKAA2

4.88e-0521312IPR032270
DomainEGF_Ca-bd_CS

FAT4 SCUBE1 FBN1 FBN2 OIT3 NOTCH2

6.22e-05971316IPR018097
Domain-

FNDC3B EBF3 TGM5 F11R PTPRG NFATC2 NFATC4 PTPRZ1 NECTIN2 TNXB PALLD UNC5D CD96 PLXNA2 PLXNB3

6.46e-05663131152.60.40.10
DomainEGF_CA

FAT4 SCUBE1 FBN1 FBN2 OIT3 NOTCH2

6.97e-05991316PS01187
DomainASX_HYDROXYL

FAT4 SCUBE1 FBN1 FBN2 OIT3 NOTCH2

7.38e-051001316PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FAT4 SCUBE1 FBN1 FBN2 OIT3 NOTCH2

1.02e-041061316IPR000152
DomainPkinase_C

SGK2 SGK3 ROCK1 PRKCG

1.28e-04371314IPR017892
DomainIg-like_fold

FNDC3B EBF3 TGM5 F11R PTPRG NFATC2 NFATC4 PTPRZ1 NECTIN2 TNXB PALLD UNC5D CD96 PLXNA2 PLXNB3

1.30e-0470613115IPR013783
DomainFBN

FBN1 FBN2

1.46e-0431312IPR011398
DomainPkinase_C

SGK2 SGK3 ROCK1 PRKCG

2.10e-04421314PF00433
DomainEGF_CA

FAT4 SCUBE1 FBN1 FBN2 OIT3 NOTCH2

2.21e-041221316SM00179
DomainEGF-like_Ca-bd_dom

FAT4 SCUBE1 FBN1 FBN2 OIT3 NOTCH2

2.41e-041241316IPR001881
DomainEGF_CA

FAT4 SCUBE1 FBN1 FBN2 NOTCH2

3.48e-04861315PF07645
DomainCUB

DCBLD1 SCUBE1 CSMD1 SEZ6

3.84e-04491314PF00431
DomainCUB

DCBLD1 SCUBE1 CSMD1 SEZ6

4.15e-04501314SM00042
DomainNFAT

NFATC2 NFATC4

4.82e-0451312IPR008366
Domain-

DCBLD1 SCUBE1 CSMD1 SEZ6

4.82e-045213142.60.120.290
DomainSushi

CR2 PAPPA CSMD1 SEZ6

4.82e-04521314PF00084
DomainCUB

DCBLD1 SCUBE1 CSMD1 SEZ6

5.19e-04531314PS01180
DomainCCP

CR2 PAPPA CSMD1 SEZ6

5.57e-04541314SM00032
DomainJmjC

KDM5D KDM6B KDM7A

6.13e-04241313PF02373
DomainAGC-kinase_C

SGK2 SGK3 ROCK1 PRKCG

6.40e-04561314IPR000961
DomainAGC_KINASE_CTER

SGK2 SGK3 ROCK1 PRKCG

6.40e-04561314PS51285
DomainS_TK_X

SGK2 SGK3 ROCK1 PRKCG

6.40e-04561314SM00133
DomainSUSHI

CR2 PAPPA CSMD1 SEZ6

6.40e-04561314PS50923
DomainSushi_SCR_CCP_dom

CR2 PAPPA CSMD1 SEZ6

6.85e-04571314IPR000436
DomainCUB_dom

DCBLD1 SCUBE1 CSMD1 SEZ6

6.85e-04571314IPR000859
DomaincEGF

SCUBE1 FBN1 FBN2

7.79e-04261313PF12662
DomaincEGF

SCUBE1 FBN1 FBN2

7.79e-04261313IPR026823
DomainSer/Thr_kinase_AS

VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

9.42e-043571319IPR008271
DomainhEGF

FAT4 FBN2 NOTCH2

9.72e-04281313PF12661
DomainS_TKc

VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

9.80e-043591319SM00220
DomainTB

FBN1 FBN2

1.00e-0371312PF00683
DomainNotch_dom

PAPPA NOTCH2

1.00e-0371312IPR000800
DomainNotch

PAPPA NOTCH2

1.00e-0371312PF00066
DomainNL

PAPPA NOTCH2

1.00e-0371312SM00004
DomainPROTEIN_KINASE_ST

VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

1.04e-033621319PS00108
Domain-

FBN1 FBN2

1.33e-03813123.90.290.10
DomainEGF

FAT4 SCUBE1 FBN1 FBN2 OIT3 TNXB NOTCH2

1.36e-032351317SM00181
DomainEGF_3

FAT4 SCUBE1 FBN1 FBN2 OIT3 TNXB NOTCH2

1.36e-032351317PS50026
DomainCa/CaM-dep_Ca-dep_prot_Kinase

PSKH1 PRKAA1 PRKAA2 MARK4

1.40e-03691314IPR020636
DomainProtein_kinase_ATP_BS

ERBB2 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

1.43e-033791319IPR017441
DomainJMJC

KDM5D KDM6B KDM7A

1.44e-03321313PS51184
DomainJmjC_dom

KDM5D KDM6B KDM7A

1.44e-03321313IPR003347
DomainPkinase

VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

1.48e-033811319PF00069
DomainPROTEIN_KINASE_ATP

ERBB2 VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

1.49e-0345913110PS00107
DomainKinase-like_dom

ERBB2 VRK3 PSKH1 WDR81 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

1.53e-0354213111IPR011009
DomainJmjC

KDM5D KDM6B KDM7A

1.58e-03331313SM00558
DomainPlexin_cytopl

PLXNA2 PLXNB3

1.70e-0391312PF08337
DomainAtaxin-2_C

USP10 HELZ

1.70e-0391312IPR009818
DomainTB_dom

FBN1 FBN2

1.70e-0391312IPR017878
DomainPAM2

USP10 HELZ

1.70e-0391312PF07145
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA2 PLXNB3

1.70e-0391312IPR013548
DomainPlexin

PLXNA2 PLXNB3

1.70e-0391312IPR031148
DomainTB

FBN1 FBN2

1.70e-0391312PS51364
DomainEGF-like_dom

FAT4 SCUBE1 FBN1 FBN2 OIT3 TNXB NOTCH2

1.89e-032491317IPR000742
DomainRHD_dimer

NFATC2 NFATC4

2.12e-03101312IPR032397
DomainRHD_dimer

NFATC2 NFATC4

2.12e-03101312PF16179
DomainREL_1

NFATC2 NFATC4

2.12e-03101312PS01204
Domain-

NFATC2 NFATC4

2.12e-031013122.60.40.340
DomainNFkB/Dor

NFATC2 NFATC4

2.12e-03101312IPR000451
DomainRHD_DNA_bind_dom

NFATC2 NFATC4

2.12e-03101312IPR011539
DomainRHD_DNA_bind

NFATC2 NFATC4

2.12e-03101312PF00554
DomainREL_2

NFATC2 NFATC4

2.12e-03101312PS50254
DomainEGF_1

FAT4 SCUBE1 FBN1 FBN2 OIT3 TNXB NOTCH2

2.16e-032551317PS00022
DomainC2

HECW1 RASA2 ESYT3 PRKCG PLCE1

2.31e-031311315PF00168
DomainProt_kinase_dom

ERBB2 VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

2.37e-0348913110IPR000719
DomainPROTEIN_KINASE_DOM

ERBB2 VRK3 PSKH1 SGK2 SGK3 PRKAA1 PRKAA2 MARK4 ROCK1 PRKCG

2.51e-0349313110PS50011
DomainEGF_2

FAT4 SCUBE1 FBN1 FBN2 OIT3 TNXB NOTCH2

2.68e-032651317PS01186
DomainC2

HECW1 RASA2 ESYT3 PRKCG PLCE1

2.81e-031371315SM00239
DomainZnF_GATA

GATA1 ZGLP1

3.08e-03121312SM00401
DomainC2

HECW1 RASA2 ESYT3 PRKCG PLCE1

3.28e-031421315PS50004
Domain-

HECW1 RASA2 ESYT3 PRKCG PLCE1

3.91e-0314813152.60.40.150
DomainZnf_GATA

GATA1 ZGLP1

4.83e-03151312IPR000679
DomainGATA

GATA1 ZGLP1

4.83e-03151312PF00320
DomainGATA_ZN_FINGER_1

GATA1 ZGLP1

5.49e-03161312PS00344
DomainDENN

DENND2B DENND4C

5.49e-03161312SM00799
DomainDENN

DENND2B DENND4C

5.49e-03161312PF02141
DomaindDENN

DENND2B DENND4C

5.49e-03161312PF03455
DomainGATA_ZN_FINGER_2

GATA1 ZGLP1

5.49e-03161312PS50114
DomainUDENN

DENND2B DENND4C

5.49e-03161312PS50946
DomainDDENN

DENND2B DENND4C

5.49e-03161312PS50947
DomaindDENN

DENND2B DENND4C

5.49e-03161312SM00801
DomaindDENN_dom

DENND2B DENND4C

5.49e-03161312IPR005112
DomainuDENN_dom

DENND2B DENND4C

5.49e-03161312IPR005113
DomainDENN

DENND2B DENND4C

5.49e-03161312PS50211
DomainDENN_dom

DENND2B DENND4C

5.49e-03161312IPR001194
DomainC2_dom

HECW1 RASA2 ESYT3 PRKCG PLCE1

6.02e-031641315IPR000008
DomainCarb_anhydrase

PTPRG PTPRZ1

6.20e-03171312PF00194
DomainCarb_anhydrase

PTPRG PTPRZ1

6.20e-03171312SM01057
Domain-

PTPRG PTPRZ1

6.20e-031713123.10.200.10
DomainALPHA_CA_2

PTPRG PTPRZ1

6.20e-03171312PS51144
PathwayKEGG_WNT_SIGNALING_PATHWAY

MYC AXIN1 WNT5B NFATC2 NFATC4 ROCK1 PRKCG SMAD4

1.25e-051511018M19428
PathwayPID_LKB1_PATHWAY

MYC PRKAA1 PRKAA2 MARK4 SMAD4

2.06e-05471015M87
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

ERBB2 CRMP1 ROCK1 PLXNA2 PLXNB3

3.09e-05511015MM14967
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

MYC ERBB2 WNT5B PRKAA1 PRKAA2 PRKAG2

3.22e-05851016M48315
PathwayWP_1Q211_COPY_NUMBER_VARIATION_SYNDROME

F11R PRKAA1 PRKAA2 PRKAG2

5.14e-05291014M39890
PathwayBIOCARTA_LEPTIN_PATHWAY

PRKAA1 PRKAA2 PRKAG2

5.65e-05111013M18053
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

ERBB2 CRMP1 ROCK1 PLXNA2 PLXNB3

9.32e-05641015M7923
PathwayWP_WNT_SIGNALING_WP428

MYC AXIN1 WNT5B NFATC2 NFATC4 PRKCG

1.59e-041131016M39669
PathwayWP_HEAD_AND_NECK_SQUAMOUS_CELL_CARCINOMA

ERBB2 PRKAA1 PRKAA2 NOTCH2 SMAD4

1.86e-04741015M39857
PathwayBIOCARTA_CHREBP_PATHWAY

PRKAA1 PRKAA2 PRKAG2

3.18e-04191013M22004
PathwayKEGG_AXON_GUIDANCE

NFATC2 NFATC4 ROCK1 UNC5D PLXNA2 PLXNB3

3.26e-041291016M5539
PathwayWP_WNT_SIGNALING_WP363

MYC AXIN1 NFATC2 PRKCG

4.79e-04511014M39721
PathwayKEGG_PATHWAYS_IN_CANCER

MYC ERBB2 RARA E2F3 KLK3 AXIN1 WNT5B PRKCG SMAD4

5.35e-043251019M12868
PathwayBIOCARTA_WNT_PATHWAY

MYC AXIN1 SMAD4

5.70e-04231013MM1527
PathwayWP_OREXIN_RECEPTOR_PATHWAY

MYC RARA CYP21A2 KLF4 PRKAA1 PAPPA GLIS1

5.81e-042001017M48048
PathwayBIOCARTA_WNT_PATHWAY

MYC AXIN1 SMAD4

6.48e-04241013M16517
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 SMAD4

7.32e-04251013M39713
PathwayREACTOME_AMPK_INHIBITS_CHREBP_TRANSCRIPTIONAL_ACTIVATION_ACTIVITY

PRKAA2 PRKAG2

7.48e-0461012MM14630
PathwayWP_BREAST_CANCER_PATHWAY

MYC ERBB2 E2F3 AXIN1 WNT5B NOTCH2

8.32e-041541016M39739
PathwayWP_WNT_SIGNALING

MYC AXIN1 WNT5B PRKCG

9.47e-04611014MM15893
PathwayWP_CANCER_PATHWAYS

MYC ERBB2 RARA E2F3 KLK3 AXIN1 WNT5B ROCK1 PRKCG NOTCH2 SMAD4

9.99e-0450710111M48302
PathwayREACTOME_TGFBR3_EXPRESSION

RARA AGO4 SMAD4

1.03e-03281013M48253
PathwayBIOCARTA_ERK_PATHWAY

MYC KLK3 KLK2

1.03e-03281013MM1391
PathwayKEGG_MEDICUS_PATHOGEN_EBV_EBNA2_TO_RBP_JK_MEDIATED_TRANSCRIPTION

MYC CR2

1.04e-0371012M47478
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

MYC RARA FBN1 AGO4 F11R SMAD4

1.05e-031611016M27871
PathwayWP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS

ERBB2 AXIN1 SMAD4

1.14e-03291013M39516
PathwayWP_LIPID_METABOLISM_PATHWAY

PRKAA1 PRKAA2 PRKAG2

1.14e-03291013M39762
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5D KDM6B KDM7A

1.14e-03291013MM14934
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

PRKAA1 PRKAA2 PRKAG2

1.14e-03291013M19861
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

PRKAA1 PRKAA2 PRKAG2

1.14e-03291013MM14980
PathwayREACTOME_ACTIVATION_OF_AMPK_DOWNSTREAM_OF_NMDARS

PRKAA1 PRKAA2 PRKAG2

1.14e-03291013M27948
PathwayWP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT

MYC ERBB2 AXIN1 WNT5B SMAD4

1.15e-031101015M39492
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ERBB2 SZT2 SMCHD1 SPIRE1 E2F3 INO80 KDM6B ANKLE2 KIAA1614 TBC1D24 USP10 AGO4 KDM7A CEP126

2.12e-085291351414621295
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TANC2 ARHGAP32 ERBB2 MYO9A SPIRE1 DENND2B DENND4C STARD9 NECTIN2 PRKAA2 MARK4 DOCK7 ANKRD11 HELZ PRKCG PALLD NOTCH2

4.45e-088611351736931259
Pubmed

Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission.

KLF4 CRMP1 ROCK1

5.72e-083135336509022
Pubmed

Deubiquitination and Activation of AMPK by USP10.

USP10 PRKAA1 PRKAA2

5.72e-083135326876938
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 ERBB2 SZT2 INTS1 SPIRE1 PFAS INO80 MED13L KDM6B KLF4 AHDC1 KCNH3 TBC1D24 ESRP2 ADAMTS7 MARK4 ANKRD11 CABIN1 NOTCH2

5.95e-0811051351935748872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ERBB2 RASA2 RTEL1 MYO9A SPIRE1 E2F3 DENND2B AHDC1 SGK2 PLEKHH1 USP10 PTPRG AOPEP NECTIN2 PRKAA2 ANKRD11 SLC35F2 PRKAG2 CSMD1 ERMARD GLIS1 NOTCH2

7.00e-0814891352228611215
Pubmed

AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation.

AXIN1 PRKAA1 PRKAA2

2.28e-074135324093678
Pubmed

Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.

MYC ERBB2 E2F3

5.69e-075135324276244
Pubmed

AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.

PRKAA1 PRKAA2 PRKAG2

1.13e-06613539224708
Pubmed

Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK).

PRKAA1 PRKAA2 PRKAG2

1.13e-066135324563466
Pubmed

Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications.

PRKAA1 PRKAA2 PRKAG2

1.13e-066135322897928
Pubmed

DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.

AXIN1 PRKAA1 PRKAA2

1.98e-067135331983282
Pubmed

Glucose recruits K(ATP) channels via non-insulin-containing dense-core granules.

PRKAA1 PRKAA2 PRKAG2

1.98e-067135317767908
Pubmed

MiR-184 expression is regulated by AMPK in pancreatic islets.

PRKAA1 PRKAA2 PRKAG2

1.98e-067135329269398
Pubmed

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.

PRKAA1 PRKAA2 PRKAG2

1.98e-067135310698692
Pubmed

Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1).

PRKAA1 PRKAA2 MARK4

3.16e-068135323184942
Pubmed

Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system.

PRKAA1 PRKAA2 PRKAG2

3.16e-068135310098881
Pubmed

Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia.

PRKAA1 PRKAA2 PRKAG2

3.16e-068135320821366
Pubmed

TSC2 mediates cellular energy response to control cell growth and survival.

PRKAA1 PRKAA2 PRKAG2

4.72e-069135314651849
Pubmed

The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.

AXIN1 PRKAA1 PRKAA2

4.72e-069135336217034
Pubmed

AMPK phosphorylation of raptor mediates a metabolic checkpoint.

PRKAA1 PRKAA2 PRKAG2

4.72e-069135318439900
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

PRKAA1 PRKAA2 MARK4 NOTCH2

6.30e-0631135431636950
Pubmed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.

MYC RARA EBF3 WNT5B PTPRZ1 UNC5D PLXNA2 NOTCH2

6.62e-06251135829031500
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

MYC GPR19 KLF4 WNT5B HOXA9 AGO4 F11R SLC35F2 NOTCH2 SMAD4

6.63e-064241351021731673
Pubmed

SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.

PRKAA1 PRKAA2 PRKAG2

6.73e-0610135319720090
Pubmed

Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19).

KLK3 PRKCG KLK2

9.22e-061113538666393
Pubmed

AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization.

PRKAA1 PRKAA2 ROCK1

9.22e-0611135327430620
Pubmed

HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.

PRKAA1 PRKAA2 PRKAG2

1.23e-0512135321344388
Pubmed

Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.

KLK3 PRKCG KLK2

1.23e-051213538288260
Pubmed

A glycolytic shift in Schwann cells supports injured axons.

MYC PRKAA1 PRKAA2

1.23e-0512135332807950
Pubmed

A molecular genetic linkage map of mouse chromosome 7.

KLK3 NECTIN2 PRKCG KLK2

1.30e-053713541981054
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

NFATC2 NFATC4 PRKCG PLCE1

1.45e-0538135412482669
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ARHGAP32 DCBLD1 TBC1D24 F11R PTPRG NECTIN2 DOCK7 ROCK1 SLC35F2 PLXNA2 NOTCH2

1.47e-055691351130639242
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

1.50e-052135212399449
Pubmed

Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.

KLK3 KLK2

1.50e-052135224270797
Pubmed

Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells.

MYC KLF4

1.50e-052135223089465
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

1.50e-052135221851253
Pubmed

Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells.

PRKAA1 PRKAA2

1.50e-052135221673972
Pubmed

Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans.

PRKAA1 PRKAA2

1.50e-052135218801964
Pubmed

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.

PRKAA1 PRKAA2

1.50e-052135221947382
Pubmed

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation.

PRKAA1 PRKAA2

1.50e-052135232839348
Pubmed

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

PRKAA1 PRKAA2

1.50e-052135220465544
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

1.50e-052135230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

1.50e-052135221440062
Pubmed

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.

PRKAA1 PRKAA2

1.50e-052135219236843
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

1.50e-052135215131124
Pubmed

The predictive value of prostate cancer biomarkers depends on age and time to diagnosis: towards a biologically-based screening strategy.

KLK3 KLK2

1.50e-052135217657743
Pubmed

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

PRKAA1 PRKAA2

1.50e-052135223905686
Pubmed

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise.

PRKAA1 PRKAA2

1.50e-052135232504885
Pubmed

Mesothelin expression in gynecologic carcinosarcoma: clinicopathological significance and correlation with HER2 expression.

ERBB2 MSLN

1.50e-052135237914528
Pubmed

Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy.

KLK3 KLK2

1.50e-052135219003994
Pubmed

Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism.

PRKAA1 PRKAA2

1.50e-052135231540695
Pubmed

Functional differences between AMPK α1 and α2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis.

PRKAA1 PRKAA2

1.50e-052135227600021
Pubmed

Genetic deletion of catalytic subunits of AMP-activated protein kinase increases osteoclasts and reduces bone mass in young adult mice.

PRKAA1 PRKAA2

1.50e-052135223486478
Pubmed

Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

PRKAA1 PRKAA2

1.50e-052135215878932
Pubmed

ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc.

MYC ROCK1

1.50e-052135224317511
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

1.50e-052135220404337
Pubmed

AMPK activation regulates neuronal structure in developing hippocampal neurons.

PRKAA1 PRKAA2

1.50e-052135224295634
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

1.50e-05213528791520
Pubmed

Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling.

ERBB2 F11R

1.50e-052135222751120
Pubmed

AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress.

PRKAA1 PRKAA2

1.50e-052135222763120
Pubmed

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

PRKAA1 PRKAA2

1.50e-052135222233421
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

1.50e-05213528307578
Pubmed

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint.

PRKAA1 PRKAA2

1.50e-052135226843621
Pubmed

Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia.

KLK3 KLK2

1.50e-052135224711254
Pubmed

Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin.

PRKAA1 PRKAA2

1.50e-052135221209024
Pubmed

Endothelial AMP-activated protein kinase regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice.

PRKAA1 PRKAA2

1.50e-052135224855056
Pubmed

AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.

PRKAA1 PRKAA2

1.50e-052135226419588
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

1.50e-05213527744963
Pubmed

Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway.

PRKAA1 PRKAA2

1.50e-052135228974562
Pubmed

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models.

PRKAA1 PRKAA2

1.50e-052135212546688
Pubmed

Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells.

ERBB2 CCL23

1.50e-052135218258606
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

1.50e-052135226408953
Pubmed

AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress.

PRKAA1 PRKAA2

1.50e-052135212788940
Pubmed

Skeletal muscle-specific inducible AMPKα1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy.

PRKAA1 PRKAA2

1.50e-052135238019084
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

1.50e-052135218006876
Pubmed

The AMP-dependent kinase pathway is upregulated in BAP1 mutant uveal melanoma.

PRKAA1 PRKAA2

1.50e-052135234347929
Pubmed

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.

PRKAA1 PRKAA2

1.50e-052135231693892
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

1.50e-052135224833718
Pubmed

ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes.

MYC ROCK1

1.50e-052135227556514
Pubmed

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice.

PRKAA1 PRKAA2

1.50e-052135232213711
Pubmed

AMPK knockdown in placental trophoblast cells results in altered morphology and function.

PRKAA1 PRKAA2

1.50e-052135225003940
Pubmed

AMPK-α1 or AMPK-α2 Deletion in Smooth Muscles Does Not Affect the Hypoxic Ventilatory Response or Systemic Arterial Blood Pressure Regulation During Hypoxia.

PRKAA1 PRKAA2

1.50e-052135229928235
Pubmed

[AMPK as a Metabolic Intersection between Diet and Physical Exercise].

PRKAA1 PRKAA2

1.50e-052135230270274
Pubmed

AMPK regulates circadian rhythms in a tissue- and isoform-specific manner.

PRKAA1 PRKAA2

1.50e-052135221483791
Pubmed

AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.

PRKAA1 PRKAA2

1.50e-052135220399918
Pubmed

Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo.

PRKAA1 PRKAA2

1.50e-052135234767944
Pubmed

Lysine Demethylase 6B Regulates Prostate Cancer Cell Proliferation by Controlling c-MYC Expression.

MYC KDM6B

1.50e-052135234862309
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

1.50e-052135224265020
Pubmed

Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice.

PRKAA1 PRKAA2

1.50e-052135226244519
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

1.50e-052135220529844
Pubmed

Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner.

PRKAA1 PRKAA2

1.50e-052135212091379
Pubmed

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

PRKAA1 PRKAA2

1.50e-052135224665903
Pubmed

Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation.

PRKAA1 PRKAA2

1.50e-052135220830737
Pubmed

CCCP induces autophagy in an AMPK-independent manner.

PRKAA1 PRKAA2

1.50e-052135222119190
Pubmed

Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.

PRKAA2 PRKAG2

1.50e-052135216275868
Pubmed

Protein expression alteration in hippocampus upon genetic repression of AMPKα isoforms.

PRKAA1 PRKAA2

1.50e-052135233492732
Pubmed

Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc Expression.

MYC NOTCH2

1.50e-052135227855169
Pubmed

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

PRKAA1 PRKAA2

1.50e-052135229038293
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

1.50e-052135223133647
GeneFamilyDNA helicases

RTEL1 INO80 FBH1

8.23e-05179231167
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CR2 PAPPA CSMD1 SEZ6

2.02e-04579241179
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5D KDM6B KDM7A

2.39e-0424923485
GeneFamilyNuclear factors of activated T-cells

NFATC2 NFATC4

2.54e-045922665
GeneFamilyPlexins

PLXNA2 PLXNB3

9.01e-049922683
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GATA1 ZGLP1

2.58e-031592282
GeneFamilyKallikreins

KLK3 KLK2

2.93e-0316922616
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN

LYPD4 ERBB2 SZT2 NUMA1 INO80 KDM5D WNT5B LARP4B PTPRZ1 ANKRD11 CABIN1 PALLD NOTCH2 PLXNB3 PLCE1

6.72e-0674613415M40863
CoexpressionGSE11961_MEMORY_BCELL_DAY7_VS_PLASMA_CELL_DAY7_UP

PFAS INO80 ANKLE2 LDHD AGO4 MARVELD2 CSMD1 NOTCH2

8.83e-061991348M9366
CoexpressionGSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY7_DN

TMEM176B INTS1 WDR81 KDM5D PLEKHH1 LDHD ADO SMAD4

9.16e-062001348M6585
CoexpressionCUI_TCF21_TARGETS_2_DN

FNDC3B CRIM1 RASA2 SPIRE1 KLK3 KLF4 DENND2B SGK3 AGO4 PTPRG PRKAA1 ROCK1 KDM7A KLK2 PALLD PLCE1

1.28e-0588813416MM1018
CoexpressionBENPORATH_ES_WITH_H3K27ME3

RARA EBF3 RFX6 NBPF11 KLF4 CR2 ADARB2 CRMP1 KCNH3 WNT5B HOXA9 FBN1 FBN2 PAPPA PRKAG2 CSMD1 PLXNA2 SEZ6

1.57e-05111513418M10371
CoexpressionDUAN_PRDM5_TARGETS

MYC RARA E2F3 ADARB2 NOTCH2

4.77e-05771345M2339
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000

FNDC3B ERBB2 RARA CRIM1 KDM5D USP37 KLK3 DENND2B KIAA1614 SGK3 STARD9 MARK4 DOCK7 PAPPA N4BP1 KDM7A MARVELD2 NOTCH2 PLCE1

2.20e-0688013219gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000

FNDC3B ERBB2 RARA SZT2 KDM5D USP37 KLK3 DENND2B KIAA1614 SGK3 SCUBE1 STARD9 MARK4 DOCK7 FAM83D N4BP1 KDM7A NOTCH2 PLCE1

2.36e-0688413219gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_1000
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_1000

FAT4 SZT2 MYO9A DCBLD1 E2F3 THSD7B KLF4 DENND2B DENND4C SCUBE1 FBN1 FBN2 F11R PTPRG PALLD PLXNA2 NOTCH2

7.38e-0678313217gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_1000
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_proximal_ERK2_WT_2500_K2

MYC FAT4 GPR19 RARA TMEM176B SZT2 MYO9A KDM5D KLK3 KIAA1614 FBN1 FBN2 PTPRG ADAMTS7 NFATC4 PTPRZ1 AOPEP RPUSD3 PAPPA PALLD PLCE1

1.76e-05120813221facebase_RNAseq_e14.5_palate_poster_proximal_ERK2_WT_2500_K2
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#4_top-relative-expression-ranked_1000

KDM5D SGK3 STARD9 DOCK7 FAM83D KDM7A NOTCH2 PLCE1

2.63e-051911328gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k4_1000
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_1000

FNDC3B ERBB2 RARA KDM5D KIAA1614 SGK3 STARD9 DOCK7 PAPPA KDM7A NOTCH2 PLCE1

4.13e-0547413212gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500

FAT4 MYO9A DCBLD1 THSD7B DENND2B DENND4C SCUBE1 FBN1 FBN2 PALLD

8.08e-0535713210gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000

FAT4 SZT2 MYO9A KLK3 KLF4 DENND2B F11R PLXNA2

8.12e-052241328gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k1_1000
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FNDC3B HECW1 RTEL1 WNT5B FBN1 PAPPA TNXB SEZ6

3.09e-0815913587ed659163f45e0c4df4782997c0786900c8186c8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 MYO9A KCNB2 ADARB2 CRMP1 PTPRG LGI2 UNC5D

8.42e-0818113589d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 MYO9A KCNB2 ADARB2 CRMP1 PTPRG LGI2 UNC5D

8.79e-081821358eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ABCA4 HECW1 FBN2 TRPM3 CSMD1 UNC5D PLCE1

9.56e-0818413582cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ABCA4 HECW1 FBN2 TRPM3 CSMD1 UNC5D PLCE1

9.56e-081841358ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 ABCA4 HECW1 FBN2 TRPM3 CSMD1 UNC5D PLCE1

9.56e-0818413582b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellNS-moderate-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

RTEL1 GATA1 KIAA1614 TBC1D24 ADAMTS7 SLC35F2 CCL23

7.04e-07164135735c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LGI2 PAPPA CSMD1 PALLD UNC5D GLIS1 NOTCH2

9.32e-0717113574ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 CRIM1 FBN1 PTPRG PAPPA TNXB PALLD

1.09e-0617513571799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 NOTCH2 SEZ6 PLCE1

1.22e-0617813572a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TANC2 ARHGAP32 ERBB2 ANKLE2 PLEKHH1 PRKAA2 KDM7A

1.26e-0617913576e965e424eebef50f0202cff75f458be395cfca1
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 KCNB2 SCUBE1 FBN1 PTPRG PAPPA PALLD

1.31e-06180135701f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYC EBF3 KDM6B PTPRG LYPD5 KCNJ14 PAPPA

1.36e-061811357ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 NOTCH2 SEZ6 PLCE1

1.41e-061821357d3a037268f026eb2f84428b1821022503cef7756
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.52e-06184135732473dbdb2de66391157c5814ef34e790806e4f2
ToppCell(0)_MSCs|World / Cell class and subclass of bone marrow stroma cells in homeostatis

TMEM176B EBF3 DENND2B FBN1 PAPPA CSMD1 PLXNA2

1.63e-061861357a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell(0)_MSCs-(00)_Lepr-MSC|World / Cell class and subclass of bone marrow stroma cells in homeostatis

TMEM176B EBF3 DENND2B FBN1 PAPPA CSMD1 PLXNA2

1.63e-061861357f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 MYO9A ADARB2 CRMP1 PTPRG LGI2 UNC5D

1.69e-061871357c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

FAT4 HECW1 KCNB2 FBN1 PTPRG TNXB PALLD

1.69e-061871357bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.75e-0618813576ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FNDC3B ABCA4 MYO9A ADARB2 CRMP1 FBN2 PTPRG

1.88e-06190135759bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.95e-06191135706760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

FAT4 HECW1 KCNB2 FBN1 PTPRG PAPPA PALLD

2.09e-061931357e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 TMEM176B HECW1 FBN1 NFATC4 PAPPA TNXB

2.31e-061961357e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 TMEM176B HECW1 FBN1 NFATC4 PAPPA TNXB

2.31e-06196135782fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT4 TMEM176B HECW1 FBN1 NFATC4 PAPPA TNXB

2.31e-06196135785e5046f774537684e1443c0fc147d562b7068d0
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

PFAS USP37 ANKLE2 RPUSD3 FAM83D SMAD4 PLCE1

2.64e-062001357691b3edf7d8449556e8bf611662eb85772959f0f
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ARHGAP32 ERBB2 DENND2B F11R PTPRZ1 AOPEP PALLD

2.64e-06200135797f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellTracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

EBF3 NUMA1 KIAA1614 TBC1D24 MARK4 ERMARD TNXB

2.64e-06200135724e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

PFAS USP37 ANKLE2 RPUSD3 FAM83D SMAD4 PLCE1

2.64e-06200135736a110aa91a791fdf1142e7869e8aa0d342402d0
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell|GW08 / Sample Type, Dataset, Time_group, and Cell type.

PFAS USP37 ANKLE2 RPUSD3 FAM83D SMAD4 PLCE1

2.64e-0620013574e077aa7faddcebdfc54667f8b3990704441005b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

PFAS USP37 ANKLE2 RPUSD3 FAM83D SMAD4 PLCE1

2.64e-062001357d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EBF3 CRMP1 SGK3 GLIS1 PLXNA2 PLCE1

1.13e-05165135650a8513d8d2630861499393a7f102b35366bad37
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 MYO9A KCNB2 ADARB2 CRMP1 LGI2

1.34e-0517013565d5f208682be21ed58320f5fc083a7898f8712da
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

EBF3 KCNB2 TGM5 FBN1 NFATC4 TNXB

1.43e-051721356e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1-2_PAX6_SCGN|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYC THSD7B ADARB2 FBN2 LGI2 SLC35F2

1.48e-05173135633170a1cc0bc87504d0501fc257a32ff17e02314
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.58e-0517513569d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.58e-0517513565a9160a9d05e01d945e77fd81bb0bd87139545cd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 DENND2B FBN1 NFATC2 PTPRZ1 PALLD

1.63e-0517613569bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 DENND2B FBN1 NFATC2 PTPRZ1 PALLD

1.63e-0517613563f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

WDR81 DENND2B WNT5B FBN2 PTPRG PAPPA

1.79e-051791356a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 FAT4 CR2 OIT3 FAM83D FAM124A

1.91e-0518113564df7972f88117108698efd06b124b232f8588981
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.91e-051811356062f00736eed96e4f4327615d093558dd7d82b20
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9A KCNB2 FBN2 LGI2 UNC5D GLIS1

1.91e-0518113566956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

1.91e-0518113567846c7b33d1b89364c5a704edaa86520db731c89
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 FAT4 CR2 OIT3 FAM83D FAM124A

1.91e-051811356cbb530566893281289026bfd93adf721decd4ca3
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 SEZ6 PLCE1

1.97e-051821356420a8fd30543e37a66ba0786215d056d308660d0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 MYO9A CRMP1 FBN2 LGI2 UNC5D

2.03e-05183135692fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR19 SZT2 GATA1 PTPRZ1 PAPPA CSMD1

2.09e-051841356e33bb572af9dfd11127105f1ac99bc958a7cafbb
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 SEZ6 PLCE1

2.16e-051851356cefd81adb480c027545a5c78dcd05669783717f4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

2.16e-0518513560b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellMesenchymal_cells-Osteo-CAR|World / Lineage and Cell class

FAT4 TMEM176B EBF3 PAPPA PALLD PLXNA2

2.16e-05185135616f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RFX6 MED13L ROCK1 KDM7A CSMD1 UNC5D

2.22e-05186135623b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 SEZ6 PLCE1

2.29e-051871356ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 SPIRE1 TRPM3 DOCK7 PAPPA PRKAG2

2.29e-051871356e3095455d2f255854f339f6b05fa87852af0700f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 PTPRZ1 SEZ6 PLCE1

2.36e-051881356c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DENND2B WNT5B SCUBE1 FBN2 PAPPA GLIS1

2.36e-051881356997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 THSD7B ADARB2 LGI2 SEZ6 PLCE1

2.66e-0519213563abee376c37c3646da33ac381aa63d50a01607a6
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_A_+_HSC|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYC ARHGAP32 TMEM176B GATA1 HOXA9 F11R

2.66e-051921356959c28d28397bc0b9d3970d1fe3293d2750e63d4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

2.66e-0519213566a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

FNDC3B MED13L PTPRG TRPM3 AOPEP ANKRD11

2.66e-051921356e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERBB2 SPIRE1 F11R TRPM3 PAPPA PRKAG2

2.82e-051941356be869e186386d03ebb670971dd24fa656b4b0edf
ToppCellILEUM-inflamed-(6)_ILC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RASA2 C20orf204 KDM6B HOXA9 HELZ CD96

2.82e-0519413564d51d49366c34ff1241770b4acc0167a43b3155a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 DENND2B FBN1 NFATC2 NFATC4 PALLD

3.07e-05197135685a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 DENND2B FBN1 NFATC2 NFATC4 PALLD

3.07e-051971356e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TMEM176B KLF4 ADARB2 PTPRZ1 PAPPA PLCE1

3.07e-051971356b2f4d7c301c0b24003374923b31d6d058e40b213
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 TMEM176B HECW1 SCUBE1 FBN1 NFATC4

3.16e-051981356300d7cc56207d77168390fa1ffcbcf76767b1b80
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 DENND2B FBN1 NFATC2 PALLD NOTCH2

3.16e-051981356a860246bcea847249a78fd2e86ed8e04371060db
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 ARHGAP32 MYO9A MED13L PTPRG AOPEP

3.16e-0519813561996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM176B DENND2B WNT5B SCUBE1 AOPEP PALLD

3.25e-051991356ec74ff85d6b61013b1f785b2fca343759feb7843
ToppCellmedial-2-mesenchymal-Myofibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FBN1 AOPEP FAM83D PAPPA PALLD GLIS1

3.25e-05199135695aae608fa35a9c82b12c6f18937ce636750ca44
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FAT4 TMEM176B DENND2B FBN1 PAPPA TNXB

3.25e-0519913563a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCellmedial-mesenchymal-Myofibroblast|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FBN1 AOPEP FAM83D PAPPA PALLD GLIS1

3.25e-051991356e25acdb5809aaff631cb06dbe4c7e59549a0bdb9
ToppCellmedial-mesenchymal-Myofibroblast-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FBN1 AOPEP FAM83D PAPPA PALLD GLIS1

3.25e-0519913569ebf4822ff9fa08574edec5dbf4f2a1488f34b1d
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1-L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-0520013562086024ce808b8796ed508a229b098eb02f8828a
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 TMEM176B FBN1 PAPPA TNXB GLIS1

3.34e-0520013568ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-0520013567e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-052001356501a3b93624df463458a35d3e6648d4ccc941724
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-052001356d1f36a8232411933b1494168ec912fd0e5246428
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-05200135635951db6a4f442ac9e13f1b8cc5b4a33481f92c8
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-052001356140aff451cd58e1d544ee668e49e37e577f6f068
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH-L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7B ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-05200135648303e499251d6754cfa991dc2d96c5563b2123c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 EBF3 FBN1 PTPRG STARD9 TNXB

3.34e-052001356c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

FAT4 TMEM176B NFATC4 PAPPA TNXB GLIS1

3.34e-05200135616a3685c41194a0a4a772e4eee372160263480e0
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-05200135685bfa7f4dd07a4d4a88330e88f5886fd1ecfdeeb
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 HECW1 FBN1 PAPPA CEP126 GLIS1

3.34e-052001356fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH|Neuronal / cells hierarchy compared to all cells using T-Statistic

THSD7B ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-0520013564802dd6cae84b41746227a5d1aa1c9b858495e36
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 EBF3 FBN1 PTPRG STARD9 TNXB

3.34e-0520013560c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAT4 ADARB2 LGI2 PTPRZ1 SEZ6 PLCE1

3.34e-05200135675649534a98bc738fca62d071de0978dc61eb24f
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 HECW1 FBN1 NFATC4 PAPPA TNXB

3.34e-05200135658b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA4 ADARB2 TGM5 CRMP1 FBN2

4.44e-051281355076ba9de63b9a4b5a2f7e7924b9a86e8eafce91f
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature|E16.5-samps / Age Group, Lineage, Cell class and subclass

THSD7B PRKAA2 PAPPA TNXB PLCE1

4.61e-0512913555e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCell368C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CRIM1 KCNB2 KIAA1614 KCNJ14 CD96

9.13e-051491355f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCell368C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CRIM1 KCNB2 KIAA1614 KCNJ14 CD96

9.13e-0514913559286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCellE17.5-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPIRE1 KCNB2 CCDC177 LDHD MSLN

9.43e-051501355201d5b68e71c6c003285428be96c488e6d526edf
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

KCNB2 SCUBE1 PTPRG PAPPA PALLD

1.03e-0415313551524557514668f515ac1bbe847611f564b265b42
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPIRE1 TRPM3 PAPPA PRKAG2 SEZ6

1.07e-041541355cd99428c282d566b5dbd31fd5a0371b7ffe9ffa2
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADARB2 WNT5B PTPRZ1 SEZ6 PLCE1

1.10e-04155135599e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAT4 ADARB2 WNT5B PTPRZ1 SEZ6

1.10e-0415513553b8def9e8f66511736ea37f259511f7c8b7743af
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GATA1 SPIRE1 TRPM3 PAPPA PRKAG2

1.13e-041561355a4b0e89255ea5d60198cb2b3e739981f9c9cf5c5
Diseasebody surface area

FNDC3B CRIM1 SMCHD1 CYP21A2 MED13L KCNB2 AXIN1 FBN1 FBN2 ADO PTPRG AOPEP ANKRD11 PAPPA

1.22e-0664313214EFO_0022196
Diseaseacute promyelocytic leukemia (is_implicated_in)

MYC RARA NUMA1

3.02e-0671323DOID:0060318 (is_implicated_in)
DiseaseHereditary Diffuse Gastric Cancer

MYC ERBB2 FAT4 PTPRG PRKAA1 NOTCH2 MSLN SMAD4 PLCE1

7.25e-062931329C1708349
DiseaseStomach Neoplasms

MYC ERBB2 FAT4 PTPRG PRKAA1 NOTCH2 MSLN SMAD4 PLCE1

8.08e-062971329C0038356
DiseaseMalignant neoplasm of stomach

MYC ERBB2 FAT4 PTPRG PRKAA1 NOTCH2 MSLN SMAD4 PLCE1

8.76e-063001329C0024623
Diseasecystatin C measurement

CYP21A2 E2F3 USP37 ADARB2 TBC1D24 LARP4B NECTIN2 ANKRD11 PRKAG2 GLIS1

1.41e-0540213210EFO_0004617
Diseaseurinary albumin to creatinine ratio

CYP21A2 NUMA1 WDR81 THSD7B MSTO1 ADO AOPEP

1.67e-051791327EFO_0007778
DiseaseACUTE PROMYELOCYTIC LEUKEMIA

RARA NUMA1

1.99e-0521322612376
DiseaseAcute promyelocytic leukemia

RARA NUMA1

1.99e-0521322cv:C0023487
Diseasecoronary artery disease

FNDC3B FAT4 INO80 KCNB2 ADARB2 DENND2B AHDC1 SCUBE1 FBN2 OIT3 ADAMTS7 TRPM3 MARK4 CABIN1 TNXB PALLD PLCE1

2.50e-05119413217EFO_0001645
Diseasepulse pressure measurement

FNDC3B GPR19 CRIM1 INO80 MED13L KDM6B AHDC1 DENND4C HOXA9 FBN1 FBN2 ADO NFATC2 TRPM3 ANKRD11 PRKAG2 PALLD PLCE1

4.99e-05139213218EFO_0005763
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

5.94e-0531322DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

1.18e-0441322DOID:0060249 (is_implicated_in)
Diseasetriacylglycerol 58:9 measurement

CYP21A2 CSMD1 TNXB

1.27e-04221323EFO_0010443
DiseaseAgents acting on the renin-angiotensin system use measurement

INO80 KDM6B FBN2 ADO NFATC2 NFATC4 PRKAG2 PLCE1

1.38e-043351328EFO_0009931
Diseasecreatinine measurement

CYP21A2 E2F3 INO80 KLF4 ADARB2 KIAA1614 CRMP1 USP10 LARP4B ADAMTS7 NECTIN2 DOCK7 ANKRD11 PRKAG2

1.54e-0499513214EFO_0004518
DiseaseIntrahepatic Cholangiocarcinoma

ERBB2 MSLN SMAD4

1.65e-04241323C0345905
DiseaseExtrahepatic Cholangiocarcinoma

ERBB2 MSLN SMAD4

1.65e-04241323C3805278
DiseaseCarcinoma, Granular Cell

MYC ERBB2 FAT4 MSLN PLCE1

1.79e-041161325C0205644
DiseaseAdenocarcinoma, Tubular

MYC ERBB2 FAT4 MSLN PLCE1

1.79e-041161325C0205645
DiseaseAdenocarcinoma, Oxyphilic

MYC ERBB2 FAT4 MSLN PLCE1

1.79e-041161325C0205642
DiseaseCarcinoma, Cribriform

MYC ERBB2 FAT4 MSLN PLCE1

1.79e-041161325C0205643
DiseaseAdenocarcinoma, Basal Cell

MYC ERBB2 FAT4 MSLN PLCE1

1.79e-041161325C0205641
DiseaseAdenocarcinoma

MYC ERBB2 FAT4 MSLN PLCE1

1.79e-041161325C0001418
Diseasetotal blood protein measurement

CRIM1 RASA2 CYP21A2 C20orf204 C4orf17 ADO MARK4 ROCK1 PLCE1

1.97e-044491329EFO_0004536
DiseaseCholangiocarcinoma

ERBB2 MSLN SMAD4

2.11e-04261323C0206698
Diseaseamino acid measurement

TANC2 FAT4 CYP21A2 ADARB2 TGM5 WNT5B PTPRG MARK4 CSMD1 UNC5D PLXNA2

2.44e-0467813211EFO_0005134
Diseaseserum urea measurement

CYP21A2 USP37 MSTO1 LARP4B PRKAG2 PLCE1

2.53e-041951326EFO_0009795
Diseaserenal cell carcinoma (is_marker_for)

MYC ERBB2 PFAS KDM6B SMAD4

2.83e-041281325DOID:4450 (is_marker_for)
Diseasephosphatidylcholine measurement

THSD7B PLEKHH1 NECTIN2 DOCK7 TNXB UNC5D SEZ6

3.01e-042841327EFO_0010226
DiseaseAlzheimer disease

VRK3 HECW1 CYP21A2 WDR81 TGM5 NECTIN2 MARK4 CSMD1 TNXB

3.47e-044851329MONDO_0004975
DiseaseHelicobacter Infections

PTPRZ1 PRKAA1

4.11e-0471322C0079487
Diseaseobesity (implicated_via_orthology)

FAT4 MED13L PRKAA1 PRKAA2 NOTCH2 PLXNB3

4.26e-042151326DOID:9970 (implicated_via_orthology)
Diseaseuric acid measurement

FAT4 CRIM1 MYO9A CYP21A2 PLEKHH1 LARP4B NFATC2 MARK4 PRKAG2 GLIS1

4.33e-0461013210EFO_0004761
Diseasered blood cell density measurement

MYO9A PSKH1 CYP21A2 INO80 KDM6B DENND2B HOXA9 LARP4B ADO TRPM3 MARK4 PRKAG2

6.09e-0488013212EFO_0007978
Diseasecataract (implicated_via_orthology)

CRIM1 INTS1 TRPM3

6.58e-04381323DOID:83 (implicated_via_orthology)
Diseasedescending aortic diameter

FBN1 ADAMTS7 NFATC4 PLCE1

6.67e-04881324EFO_0021788
DiseasePancreatic carcinoma, familial

PALLD SMAD4

7.00e-0491322C2931038
DiseaseCleft upper lip

MYC ABCA4 ESRP2

7.11e-04391323C0008924
DiseaseNeoplasm Recurrence, Local

ERBB2 KLK3 HOXA9

7.11e-04391323C0027643
Diseaselung cancer (is_marker_for)

MYC GATA1 AXIN1

7.11e-04391323DOID:1324 (is_marker_for)
Diseasebasophil count, eosinophil count

KDM6B LARP4B NFATC2 MARK4 N4BP1 TNXB

7.75e-042411326EFO_0004842, EFO_0005090
Diseasemonocyte count

RASA2 SZT2 ARHGAP30 MED13L DENND2B AHDC1 KIAA1614 SGK2 SGK3 HOXA9 ADO LYPD5 MARK4 CABIN1 PLCE1

8.50e-04132013215EFO_0005091
Diseasealbuminuria

CYP21A2 ADO PRKAG2 CSMD1

8.55e-04941324EFO_0004285
Diseaselymphocyte count

CYP21A2 E2F3 MED13L ANKLE2 FBN1 ADO ZGLP1 NFATC2 NECTIN2 PRKAA2 MARK4 ANKRD11 HELZ PAPPA NOTCH2 PLCE1

8.59e-04146413216EFO_0004587
Diseaseubiquitin-conjugating enzyme E2 G2 measurement

CYP21A2 TNXB

8.73e-04101322EFO_0022035
DiseaseSquamous cell carcinoma of esophagus

FAT4 TNXB NOTCH2 PLCE1

8.89e-04951324C0279626
DiseaseAdenocarcinoma of large intestine

ERBB2 AXIN1 MARK4 SMAD4

9.25e-04961324C1319315
Diseaseeosinophil count

RASA2 CYP21A2 GATA1 RFX6 KDM6B ANKLE2 LARP4B ADO NFATC2 NECTIN2 MARK4 ANKRD11 N4BP1 TNXB NOTCH2 SMAD4

1.02e-03148813216EFO_0004842
Diseasecortical surface area measurement

TANC2 CYP21A2 MED13L KIAA1614 AXIN1 SCUBE1 FBN1 FBN2 ADAMTS7 AOPEP PAPPA PRKAG2 TNXB PLXNA2 PLCE1

1.03e-03134513215EFO_0010736
Diseasegastric adenocarcinoma (is_implicated_in)

RTEL1 PLCE1

1.06e-03111322DOID:3717 (is_implicated_in)
DiseaseMammary Ductal Carcinoma

ERBB2 SMAD4

1.06e-03111322C0021367
DiseaseInvasive Ductal Breast Carcinoma

ERBB2 SMAD4

1.06e-03111322C1134719
DiseasePancreatic Neoplasm

MYC PALLD MSLN SMAD4

1.08e-031001324C0030297
DiseaseAcute Promyelocytic Leukemia

FNDC3B RARA NUMA1

1.15e-03461323C0023487
DiseaseMalignant neoplasm of pancreas

MYC PALLD MSLN SMAD4

1.16e-031021324C0346647
Diseaseplatelet crit

RTEL1 CYP21A2 KDM6B DENND2B KIAA1614 HOXA9 ADO NECTIN2 MARK4 KDM7A SMAD4 PLCE1

1.20e-0395213212EFO_0007985
Diseasemicrophthalmia (implicated_via_orthology)

CRIM1 TRPM3

1.27e-03121322DOID:10629 (implicated_via_orthology)
Diseasesexual dimorphism measurement

FNDC3B RARA CRIM1 RASA2 KCNB2 FBN1 ADO PTPRG NFATC4 AOPEP NECTIN2 ANKRD11 PAPPA

1.41e-03110613213EFO_0021796
DiseaseMedulloblastoma

MYC ERBB2 AXIN1

1.47e-03501323C0025149
Diseaseamyotrophic lateral sclerosis (biomarker_via_orthology)

RARA PTPRZ1

1.50e-03131322DOID:332 (biomarker_via_orthology)
Diseasebody weight

CRIM1 RASA2 SMCHD1 CYP21A2 THSD7B KCNB2 AXIN1 SGK2 SGK3 FBN2 PTPRG NFATC2 NFATC4 PAPPA

1.58e-03126113214EFO_0004338
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN1 FBN2 SMAD4

1.74e-03531323C4707243
Diseasebeta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement

FAT4 HECW1

1.74e-03141322EFO_0004670, EFO_0006794
Diseasemean arterial pressure

SZT2 THSD7B FBN2 ADO NFATC2 MARK4 SEZ6 PLCE1

1.87e-034991328EFO_0006340
Diseasealcohol use disorder (implicated_via_orthology)

ERBB2 KDM5D KDM6B PRKCG NOTCH2

1.88e-031951325DOID:1574 (implicated_via_orthology)
Diseasecreatinine measurement, glomerular filtration rate

CYP21A2 INO80 LARP4B PRKAG2

1.92e-031171324EFO_0004518, EFO_0005208
Diseasefacial morphology

LGI2 CSMD1 UNC5D

1.94e-03551323EFO_0004743
DiseaseDiffuse Large B-Cell Lymphoma

MYC NECTIN2 NOTCH2

1.94e-03551323C0079744
Diseaseeosinophil percentage of leukocytes

CYP21A2 GATA1 RFX6 KDM6B LDHD ADO NFATC2 MARK4 N4BP1 NOTCH2

1.97e-0374613210EFO_0007991
Diseaseovarian cancer (is_implicated_in)

ERBB2 MSLN SMAD4

2.04e-03561323DOID:2394 (is_implicated_in)
Diseasealkaline phosphatase measurement

TMEM176B PSKH1 CYP21A2 WDR81 DENND2B KIAA1614 AXIN1 CRMP1 NFATC4 NECTIN2 MARK4 PLCE1

2.05e-03101513212EFO_0004533
Diseasecalcium measurement

TMEM176B CYP21A2 NUMA1 WDR81 FBN2 AOPEP MARK4 PRKAG2 PLCE1

2.12e-036281329EFO_0004838
Diseaseasthma, Eczema, allergic rhinitis

MYC RTEL1 NFATC2 TCHHL1

2.17e-031211324EFO_0005854, HP_0000964, MONDO_0004979
Diseaseureidopropionic acid measurement

CYP21A2 ADARB2

2.29e-03161322EFO_0010542
Diseasebacteriemia

PTPRG PALLD

2.58e-03171322EFO_0003033
Diseasepancreatic ductal carcinoma (is_marker_for)

PALLD MSLN SMAD4

2.61e-03611323DOID:3587 (is_marker_for)
DiseaseCalcium channel blocker use measurement

AHDC1 FBN2 NFATC2 PRKAG2 PLCE1

2.76e-032131325EFO_0009930
Diseaseplatelet measurement

CFAP251 CYP21A2 KDM6B TRPM3 MARK4 DOCK7

3.00e-033151326EFO_0005036
Diseaseovarian neoplasm

MYC ERBB2 NECTIN2 MSLN

3.14e-031341324C0919267
Diseaseosteoarthritis

HECW1 THSD7B ADARB2 SCUBE1 PTPRG

3.29e-032221325MONDO_0005178
DiseaseMalignant neoplasm of ovary

MYC ERBB2 NECTIN2 MSLN

3.40e-031371324C1140680
Diseaseserum homoarginine measurement

CYP21A2 CRMP1

3.58e-03201322EFO_0005421
DiseaseAdenocarcinoma of prostate

MYC AXIN1

3.58e-03201322C0007112
DiseaseBladder Neoplasm

MYC HOXA9 NECTIN2 NOTCH2

3.67e-031401324C0005695
Diseaseascending aortic diameter

MED13L FBN1 FBN2 PLCE1

3.67e-031401324EFO_0021787
DiseaseMalignant neoplasm of urinary bladder

MYC HOXA9 NECTIN2 NOTCH2

3.76e-031411324C0005684
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

PSKH1 CYP21A2 NECTIN2 DOCK7

4.06e-031441324EFO_0004611, EFO_0020943
Diseaseneurodegenerative disease (implicated_via_orthology)

FAT4 TBC1D24 MARK4 PRKAG2

4.16e-031451324DOID:1289 (implicated_via_orthology)
Diseasecoronary artery calcification

RASA2 MROH5 MED13L ADAMTS7 STARD9 DOCK7 CCL23

4.22e-034501327EFO_0004723
Diseasecortical thickness

ABCA4 CRIM1 KIAA1614 CRMP1 SCUBE1 FBN1 FBN2 ADAMTS7 DOCK7 PRKAG2 PLXNA2 PLCE1

4.31e-03111313212EFO_0004840

Protein segments in the cluster

PeptideGeneStartEntry
RYTGSLTTPPCSEIV

PTPRG

251

P23470
SVLVTPTSDCYNPAA

FAM222A

351

Q5U5X8
PSETDGYVAPLTCSP

ERBB2

1121

P04626
LTPCTSSGADPYVRV

ESYT3

781

A0FGR9
IYASSSPPDTGQRFC

PRKAG2

191

Q9UGJ0
CSVPPSDTDTYRAGA

ANKLE2

176

Q86XL3
ISYTPRSIPCSLLES

CCL23

56

P55773
TPRTPSCSADDYADL

ANKRD11

1721

Q6UB99
TSDTQCSSVPEPRYG

CSMD1

1736

Q96PZ7
IYPGTSSPAVDRLCV

ABCA4

1946

P78363
YTEASGPCILTPHRD

ADO

176

Q96SZ5
RTSCGSPNYAAPEVI

PRKAA2

171

P54646
LGTAPSRAYSPACSV

C20orf204

16

A0A1B0GTL2
RSCTETATPLPSQYL

GPR19

26

Q15760
YTLVVVCSDAGSPEP

FAT4

2431

Q6V0I7
SDQSGRPCVYTVGSP

AOPEP

261

Q8N6M6
TSSAVCSSPDYLREP

AHDC1

11

Q5TGY3
TYVRCTRSVSIPAPA

AGO4

791

Q9HCK5
RSPIYPLSDSETSAC

DENND2B

41

P78524
PSTCGVQVYPELESR

ADAMTS7

201

Q9UKP4
VETPACTLELPTEYG

CFAP251

381

Q8TBY9
KPECSESYTLTPEVG

RARA

171

P10276
CDPYATVSLVGPSRN

RASA2

191

Q15283
YTDTSSPVACRTPVL

RFX6

856

Q8HWS3
STSPCGDARLHSPYE

ADARB2

486

Q9NS39
CVASPRVTAVPLDSY

INO80

1011

Q9ULG1
TVPYSVCVSTAREPS

KCNH3

241

Q9ULD8
YREPLCLSPASSGSS

NFATC2

161

Q13469
FSGSRCELYTAPPST

NOTCH2

1406

Q04721
STCSFTYPIRAGNDP

KLF4

146

O43474
LPTQEPALGTTCYAS

KLK2

141

P20151
VCPVSRSSNEATSPY

KDM7A

491

Q6ZMT4
ALYCGIRPSNPESSE

MED13L

616

Q71F56
SYPPCTLTDEETRTE

INTS1

776

Q8N201
KETTRGPRYCPSIES

MTO1

306

Q9Y2Z2
IASACGDPETPRTHY

HECW1

546

Q76N89
PRPEEASVYTSATAC

KDM5D

1306

Q9BY66
DSSVSPAATTACVPY

KDM6B

371

O15054
PLDSRTPCRTAYATT

KIAA1614

736

Q5VZ46
VPASCAVSATYERSP

LARP4B

586

Q92615
TTCGTPEYIAPEVLV

PSKH1

256

P11801
RTTRPSSISGYDIPE

CYP21A2

366

P08686
YSAPSRFCSTVETPL

FAM124A

431

Q86V42
TCLAPSLTTDYRPGL

PLXNA2

1096

O75051
YGVTSRCVTLPLDSP

PLXNB3

351

Q9ULL4
SVSPVALDPCSAYIS

OIT3

16

Q8WWZ8
ALDTVTVPYRLCSSP

MSTO1

336

Q9BUK6
DACDVYADSRPPRST

PERCC1

111

A0A1W2PR82
CSSGTYFPEQSDLEP

FAM83D

96

Q9H4H8
TLSLTDYACGSPPVD

HOXA9

151

P31269
VSPPGVSIASYSRVC

LYPD4

96

Q6UWN0
PGYLCSLSPEELSSV

MSLN

446

Q13421
TTRTFCGTPDYIAPE

PRKCG

511

P05129
YNGSLTSPPCTDTVD

PTPRZ1

231

P23471
PVTLSSCQRGETYSP

PAPPA

1186

Q13219
LSSSVRNTCYPEDIP

ARHGAP32

1561

A7KAX9
PPRGITSSEEYTLCK

HELZ

171

P42694
ISPVTPEHAGTYRCV

KIR3DX1

81

Q9H7L2
RTYEVPGTPVCSAKE

KCNJ14

351

Q9UNX9
SRVYLECRVTGNPTP

PALLD

286

Q8WX93
TGLYPASTVCPTRED

GATA1

101

P15976
YTATTKCSPSVDPER

FBH1

296

Q8NFZ0
SNPGDTGYCPTRETS

KCNB2

896

Q92953
AYIEGTSTEVPCLPE

CABIN1

1031

Q9Y6J0
TVTYTCNPGPERGVE

CR2

551

P20023
STQGPIEVYLCPEET

E2F3

341

O00716
YSPRDCRTLVSAVPE

DOCK7

91

Q96N67
TSPDGTRCIDVRPGY

FBN1

321

P35555
SPVCEESYPSVTLRT

CEP126

911

Q9P2H0
SKPEGCSPEEVITYT

FNDC3B

496

Q53EP0
ELVSTDPRPASYSFC

AXIN1

31

O15169
GYSTDVCVPISRLPE

LDHD

386

Q86WU2
CSYPSSTAVQESPVR

C4orf17

81

Q53FE4
TACPPDSYETQVRLT

CRIM1

266

Q9NZV1
TVPEGYTCVEATPSA

DENND4C

56

Q5VZ89
IRYISDGVECSPPAS

MARVELD2

106

Q8N4S9
TYVCTERPGAERPSL

MARK4

511

Q96L34
DALPPDYSVVRGCTT

LYPD5

91

Q6UWN5
PTSVSCGDVLYLPTS

KRTAP26-1

31

Q6PEX3
CPEAEGSRYVLTSPR

CCDC177

81

Q9NQR7
GDPITTCLSPSVYDI

ERMARD

6

Q5T6L9
TCPPGYVFRTETETC

FBN2

836

P35556
PATGYEALAEASCPT

GLIS1

566

Q8NBF1
EGTAPSYLENATPCI

EBF3

251

Q9H4W6
GTSDSYSAPRDCLTP

DCBLD1

691

Q8N8Z6
VPDSENSYVLSCGVP

SCUBE1

441

Q8IWY4
DTTTTFCGTPEYLAP

SGK3

316

Q96BR1
PTTPDYLTSLLACGD

CRMP1

311

Q14194
TCYPLESRPSLSLGT

NUMA1

1936

Q14980
CTEGGDYCLIPRTSP

ARHGAP30

1021

Q7Z6I6
LTCSEQDGSPPSEYT

F11R

151

Q9Y624
SERPYSCTPTGRVSS

MROH5

6

Q6ZUA9
RPTATYCAVTDGIPA

RPUSD3

166

Q6P087
SPAAGDPESSLCVEY

RTEL1

806

Q9NZ71
TPTTTVYRCGPLIDL

TARS1

246

P26639
QTESADGPRTRCPVY

SZT2

1226

Q5T011
SGFDPECERTTPSIY

SLC6A16

231

Q9GZN6
PNLPVYVVDCSSSGT

SMCHD1

976

A6NHR9
EPEDTTSTFCGTPEY

SGK2

186

Q9HBY8
TSTFCGTPEYLAPEV

SGK2

191

Q9HBY8
NSTVSDVLCIGPPEY

LGI2

186

Q8N0V4
PQVEAYSPSACSVRG

NFATC4

586

Q14934
STPSVYLGLTDSCQP

NBPF11

641

Q86T75
AVPCNRSGSESAPLY

PLCE1

1241

Q9P212
RSGLCSPSYVAVTPF

MYC

66

P01106
VPSSCPIVTVDGYVD

SMAD4

341

Q13485
YERSCDELSPVSPTQ

TANC2

1816

Q9HCD6
SCPGPRAVTVRYTFT

PPP1R3G

241

B7ZBB8
SQPEESYCLVVSSPS

STARD9

3846

Q9P2P6
TVPCPYSSKADVVDS

ESRP2

241

Q9H6T0
LYCSTPTRTAEPAES

SLC35F2

331

Q8IXU6
DTVCDRSDPVFPTTG

TMEM176B

161

Q3YBM2
LRTSCGSPNYAAPEV

PRKAA1

181

Q13131
DIPCRTVTPDASVYS

TBC1D24

61

Q9ULP9
YGRPCESLVTFTETP

CD96

81

P40200
PGPSEYCPSERTISE

SPIRE1

741

Q08AE8
PDSRRPSSCIDIYVS

TRPM3

1416

Q9HCF6
SAYAVCPDITATVTP

PFAS

826

O15067
PGYTGEDCSTRTCPR

TNXB

361

P22105
VDPSPDYCLRNESTG

WNT5B

281

Q9H1J7
TPTYPVGTTVEFSCD

SEZ6

546

Q53EL9
YEAAPTSTLTCDSGP

VRK3

181

Q8IV63
TDPATDCALRGSPVY

TGM5

206

O43548
PDLTVSRTYSGPICL

UNC5D

446

Q6UXZ4
SSEGDYAIPPDACSL

PLEKHH1

536

Q9ULM0
CDTAVGTPDYISPEV

ROCK1

231

Q13464
SLPEQSPGYRCRSLT

nan

6

Q8N9P0
NSPDISATRAYTCPV

USP37

461

Q86T82
RSSVELPPYSGTVLC

USP10

26

Q14694
QEPCSVERGAVYSSP

TCHHL1

786

Q5QJ38
RPVDPSFCSSSGYIQ

THSD7B

976

Q9C0I4
IIPTYSLPCSSRSQE

ZGLP1

161

P0C6A0
PVGETTQCPSYAREG

WDR81

191

Q562E7
LPTQEPALGTTCYAS

KLK3

141

P07288
YICNTDPETDGLSPS

N4BP1

481

O75113
PRIGECLVAPSSYQS

MYO9A

1536

B2RTY4
LSCDVRSNPEPTGYD

NECTIN2

281

Q92692