Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrofilament motor activity

MYO1C MYO5A MYO7B MYO1H

2.21e-0738284GO:0000146
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYO1C MYO5A MYO7B MYO1H

2.13e-05118284GO:0003774
GeneOntologyMolecularFunctionactin filament binding

MYO1C MYO5A MYO7B MYO1H

2.69e-04227284GO:0051015
GeneOntologyMolecularFunctionATP-dependent activity

NVL MYO1C MYO5A MYO7B MYO1H

1.48e-03614285GO:0140657
GeneOntologyBiologicalProcessactin filament-based movement

MYO1C MYO5A MYO7B MYO1H

5.19e-05153284GO:0030048
GeneOntologyBiologicalProcessvesicle transport along actin filament

MYO1C MYO5A

6.36e-059282GO:0030050
GeneOntologyBiologicalProcessactin filament-based transport

MYO1C MYO5A

9.70e-0511282GO:0099515
GeneOntologyCellularComponentmyosin complex

MYO1C MYO5A MYO7B MYO1H

1.11e-0659284GO:0016459
GeneOntologyCellularComponentunconventional myosin complex

MYO1C MYO5A

9.45e-0511282GO:0016461
GeneOntologyCellularComponentactin-based cell projection

MYO1C MYO5A MYO7B MYO1H

4.87e-04278284GO:0098858
GeneOntologyCellularComponenttelomerase holoenzyme complex

NVL SMG6

5.09e-0425282GO:0005697
GeneOntologyCellularComponentmicrovillus

MYO1C MYO7B MYO1H

5.85e-04123283GO:0005902
GeneOntologyCellularComponentbrush border

TRPM6 MYO1C MYO7B

1.08e-03152283GO:0005903
DomainMYOSIN_MOTOR

MYO1C MYO5A MYO7B

1.96e-0538263PS51456
DomainMyosin_head

MYO1C MYO5A MYO7B

1.96e-0538263PF00063
DomainMyosin_head_motor_dom

MYO1C MYO5A MYO7B

1.96e-0538263IPR001609
DomainMYSc

MYO1C MYO5A MYO7B

1.96e-0538263SM00242
DomainIQ

MYO1C MYO5A MYO7B

1.29e-0471263PF00612
DomainIQ

MYO1C MYO5A MYO7B

1.90e-0481263SM00015
DomainIQ_motif_EF-hand-BS

MYO1C MYO5A MYO7B

2.60e-0490263IPR000048
DomainIQ

MYO1C MYO5A MYO7B

2.86e-0493263PS50096
DomainIG

VSTM4 FGFR2 IL1R2 UNC5B

2.57e-03421264SM00409
DomainIg_sub

VSTM4 FGFR2 IL1R2 UNC5B

2.57e-03421264IPR003599
DomainRRM_1

PPARGC1B SRSF10 DND1

2.93e-03208263PF00076
DomainRRM

PPARGC1B SRSF10 DND1

3.30e-03217263SM00360
DomainRRM_dom

PPARGC1B SRSF10 DND1

3.75e-03227263IPR000504
DomainRRM

PPARGC1B SRSF10 DND1

3.89e-03230263PS50102
DomainIGc2

FGFR2 IL1R2 UNC5B

4.13e-03235263SM00408
DomainIg_sub2

FGFR2 IL1R2 UNC5B

4.13e-03235263IPR003598
DomainIG_LIKE

VSTM4 FGFR2 IL1R2 UNC5B

4.46e-03491264PS50835
Domain-

PPARGC1B SRSF10 DND1

4.59e-032442633.30.70.330
DomainIg-like_dom

VSTM4 FGFR2 IL1R2 UNC5B

4.85e-03503264IPR007110
DomainNucleotide-bd_a/b_plait

PPARGC1B SRSF10 DND1

5.36e-03258263IPR012677
Domain-

VSTM4 FGFR2 IL1R2 UNC5B

1.26e-026632642.60.40.10
DomainIg-like_fold

VSTM4 FGFR2 IL1R2 UNC5B

1.56e-02706264IPR013783
Pubmed

NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.

NVL RPL5

6.71e-07229215469983
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

NVL SIX5 MYO7B MEGF11

5.84e-0614229419851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

NVL SIX5 MYO7B MEGF11

6.01e-0614329420198315
Pubmed

Mapping of unconventional myosins in mouse and human.

MYO1C MYO5A MYO7B

8.79e-06482938884266
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

PPARGC1B SRSF10 DND1 RPL5 BRWD1

9.37e-0634729516033648
Pubmed

FGFR2 is associated with hair thickness in Asian populations.

FGFR2 MYO5A

5.21e-051329219590514
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

NVL SRSF10 TSPYL1 MYO1C HACD3 RPL5

6.03e-0584729635850772
Pubmed

Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.

MYO5A MYO7B

6.07e-05142928022818
Pubmed

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3β-β-Catenin Signaling Pathway.

MYO1C MYO5A HACD3 RPL5

1.16e-0430529433194618
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

NVL SRSF10 MYO1C MYO5A RPL5

1.97e-0466029532780723
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

SRSF10 MYO1C MYO5A RPL5

2.03e-0435329427545878
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

NVL SRSF10 MYO1C MYO5A RPL5

2.04e-0466529530457570
Pubmed

Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP.

MYO1C MYO5A

2.88e-043029237019383
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

NVL SRSF10 MYO1C CLK2 RPL5

3.01e-0472329534133714
Pubmed

Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.

FGFR2 UNC5B

3.08e-043129222076636
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

NVL TSPYL1 MYO5A HACD3 RPL5

3.76e-0475929535915203
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

SRSF10 HACD3 RPL5

5.12e-0418829329721183
Pubmed

ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.

DGKD FGFR2

5.66e-044229229107558
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM6 ASIC4

6.21e-044429219322198
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

MYO1C MYO5A HACD3

6.31e-0420229333005030
Pubmed

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

MYO1C MYO7B

6.50e-044529222114352
Pubmed

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.

PPARGC1B RPL5

7.09e-044729231097699
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DGKD SRSF10 MYO1C MYO5A HACD3 RPL5

7.54e-04135329629467282
Pubmed

Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.

SRSF10 HACD3 RPL5

8.19e-0422129331796584
Cytoband17p13.3

MYO1C SMG6

1.43e-038829217p13.3
CytobandEnsembl 112 genes in cytogenetic band chr15q22

HACD3 MEGF11

3.17e-03132292chr15q22
CytobandEnsembl 112 genes in cytogenetic band chr2q11

IL1R2 UNC50

4.22e-03153292chr2q11
GeneFamilyMyosins, class I

MYO1C MYO1H

3.58e-0582121097
GeneFamilyRNA binding motif containing

PPARGC1B SRSF10 DND1

1.83e-03213213725
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

FGFR2 UNC5B

1.48e-02161212593
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SRSF10 RPL5

1.85e-02181212694
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DGKD ASIC4 MEGF11 UNC5B

5.81e-061832945e361be3ae3fe05098968e58427630127bd12675
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.

RSRP1 SRSF10 HACD3 RPL5

6.88e-06191294e0072b392f8833fab5e1006148c46a17cce894bc
DiseaseCongenital small ears

SIX5 FGFR2

7.47e-0441292C0152423
Diseasethyroid peroxidase antibody measurement, anti-thyroglobulin antibody measurement

TRPM6 SMG6

8.99e-0445292EFO_0005666, EFO_0009896
DiseaseEndometrial Neoplasms

SRSF10 FGFR2

1.49e-0358292C0014170
Diseasehemoglobin A1 measurement

VSTM4 RSRP1 DGKD SMG6

1.60e-03520294EFO_0007629
Diseasemagnesium measurement

TRPM6 FGFR2

1.92e-0366292EFO_0004845

Protein segments in the cluster

PeptideGeneStartEntry
AKRYSRSDKRRNRYR

SMG6

241

Q86US8
RRVYDRRYCGSYRRN

CLK2

66

P49760
RVYSIDYGRRKRNAF

NVL

41

O15381
YASKGNLREYLRARR

FGFR2

566

P21802
KTAYRRGLRTMYRRR

MEGF11

71

A6BM72
RRAELYRRKDFSAYT

LHCGR

646

P22888
INFRHLYKQRRRRYG

HACD3

341

Q9P035
NRGSARYLARKYNRN

ASIC4

391

Q96FT7
RTCRRKYPNYGRRNR

BRWD1

796

Q9NSI6
SFQRSKRRYFKLRGR

DGKD

66

Q16760
LNRGFAYARYSSRRG

DND1

96

Q8IYX4
SRGLRYYYRRDIVRK

ETV2

296

O00321
RNRRGEKYGFITYRC

PPARGC1B

936

Q86YN6
RSRAALKACYRGNRY

SIX5

211

Q8N196
RRRREGKTDYYARKR

RPL5

21

P46777
RSCRFRGRHYKREFR

IL1R2

26

P27930
SRRRHQRKYRRYSRS

RSRP1

66

Q9BUV0
SRSRSRRYRERRYGF

RSRP1

86

Q9BUV0
TAGAKRYKYLRRLFR

UNC50

26

Q53HI1
IGRAYRSNYTRKHFR

TRPM6

521

Q9BX84
RRRSRSRSFDYNYRR

SRSF10

126

O75494
KFGRMRRHYLERRNY

TSPYL1

256

Q9H0U9
SRRAYVRIAYLRKNF

UNC5B

141

Q8IZJ1
YARLARAYRRSQRAS

UTS2R

231

Q9UKP6
RFYYCRHFRGRKQAR

LINC01356

6

Q8N9X3
YYGNFSRSAKRRRLR

VSTM4

86

Q8IW00
RVRRAGFAYRRKYEA

MYO1C

656

O00159
RVRRAGFAYRRKYEH

MYO1H

626

Q8N1T3
RGYQARCYAKFLRRT

MYO5A

801

Q9Y4I1
SYLRGFLARNRYRKI

MYO5A

846

Q9Y4I1
GYRYRKEFLRQRRAA

MYO7B

776

Q6PIF6