Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of RNA splicing

ZNF638 RPS26 RBMXL2 RBMXL1 RBMX

7.90e-06207285GO:0043484
GeneOntologyBiologicalProcesspositive regulation of mRNA splicing, via spliceosome

RBMXL2 RBMXL1 RBMX

2.86e-0544283GO:0048026
GeneOntologyBiologicalProcesspositive regulation of mRNA processing

RBMXL2 RBMXL1 RBMX

3.96e-0549283GO:0050685
GeneOntologyBiologicalProcesspositive regulation of RNA splicing

RBMXL2 RBMXL1 RBMX

8.42e-0563283GO:0033120
GeneOntologyCellularComponentsupraspliceosomal complex

RBMXL1 RBMX

1.11e-054292GO:0044530
DomainRBM1CTR

RBMXL2 RBMXL1 RBMX

1.68e-078283PF08081
DomainRBM1CTR

RBMXL2 RBMXL1 RBMX

1.68e-078283IPR012604
DomainRibosomal_S26e

RPS26 RPS26P11

2.17e-062282PF01283
DomainRibosomal_S26e

RPS26 RPS26P11

2.17e-062282IPR000892
DomainRIBOSOMAL_S26E

RPS26 RPS26P11

2.17e-062282PS00733
DomainRRM_dom_euk

RBMXL2 RBMXL1 RBMX

5.24e-0623283IPR003954
DomainRRM_1

RBMXL2 RBMXL1 RBMX

5.24e-0623283SM00361
DomainRRM_1

ZNF638 RBMXL2 RBMXL1 RBMX

2.48e-04208284PF00076
DomainRRM

ZNF638 RBMXL2 RBMXL1 RBMX

2.92e-04217284SM00360
DomainRRM_dom

ZNF638 RBMXL2 RBMXL1 RBMX

3.46e-04227284IPR000504
DomainRRM

ZNF638 RBMXL2 RBMXL1 RBMX

3.64e-04230284PS50102
Domain-

ZNF638 RBMXL2 RBMXL1 RBMX

4.55e-042442843.30.70.330
DomainNucleotide-bd_a/b_plait

ZNF638 RBMXL2 RBMXL1 RBMX

5.61e-04258284IPR012677
DomainAT_hook

KMT2B SRCAP

7.43e-0427282SM00384
DomainAT_hook_DNA-bd_motif

KMT2B SRCAP

7.43e-0427282IPR017956
DomainCYSTEINE_SWITCH

ADAM19 MMP16

1.71e-0341282PS00546
DomainPept_M10_metallopeptidase

ADAM19 MMP16

1.88e-0343282IPR001818
DomainMetalloPept_cat_dom

ADAM19 MMP16

6.53e-0381282IPR024079
Domain-

ADAM19 MMP16

6.53e-03812823.40.390.10
DomainSH3_2

MIA2 CASKIN2

7.33e-0386282IPR011511
DomainSH3_2

MIA2 CASKIN2

7.33e-0386282PF07653
DomainZINC_PROTEASE

ADAM19 MMP16

9.43e-0398282PS00142
Pubmed

Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.

RPS26 RBMXL2 GAR1 RBMXL1 RBMX

2.01e-0715330528225217
Pubmed

Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts.

RBMXL2 RBMX

7.19e-07230221327109
Pubmed

RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.

RBMXL1 RBMX

2.16e-06330210391207
Pubmed

Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.

RBMXL1 RBMX

2.16e-06330234458856
Pubmed

RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.

RBMXL1 RBMX

2.16e-06330217188681
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ZNF638 RPS26 LMTK3 SRCAP GAR1 NRXN2 RBMXL1 RBMX

2.72e-06108230838697112
Pubmed

SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.

RBMXL1 RBMX

4.31e-06430219403048
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

ZNF638 RBMXL2 AGO4 RBMXL1 RBMX

1.12e-0534730516033648
Pubmed

The Penta-EF-Hand ALG-2 Protein Interacts with the Cytosolic Domain of the SOCE Regulator SARAF and Interferes with Ubiquitination.

FNDC3A MIA2

2.01e-05830232878247
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

RPRD2 ITCH WIPF2 RBMX

3.75e-0522030424550385
Pubmed

TRIM24 is an insulin-responsive regulator of P-bodies.

AGO4 RBMXL1 RBMX

4.55e-058030335803934
Pubmed

RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.

RBMXL2 RBMX

5.58e-051330210749975
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

LMTK3 SRCAP

6.50e-051430228263302
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

RPRD2 RPS26 KMT2B SRCAP WIPF2

6.74e-0550630530890647
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

TTBK2 RPS26 RPS26P11 RBMXL2 RBMXL1 RBMX

7.24e-0584430625963833
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FNDC3A RPRD2 AGO4 NRXN2 CASKIN2

8.31e-0552930514621295
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF638 RPRD2 ERF KMT2B SRCAP GAR1 RBMX

9.32e-05129430730804502
Pubmed

The DNA sequence and biology of human chromosome 19.

GFY MEF2B ERF KMT2B

1.01e-0428430415057824
Pubmed

Serological detection of cutaneous T-cell lymphoma-associated antigens.

ZNF638 MIA2

1.09e-041830211149944
Pubmed

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.

SYN1 NRXN2

1.09e-041830228864826
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

SYN1 WIPF2 RBMX

1.21e-0411130322558309
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

ZNF638 RPS26 RPS26P11 MIA2 GAR1 LETM1 RBMX

1.62e-04141530728515276
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

ZNF638 RPS26P11 GAR1 RBMX EZHIP

1.68e-0461530531048545
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RBMXL2 MIA2 SRCAP GAR1 RBMXL1 LETM1 RBMX

1.83e-04144230735575683
Pubmed

Intrinsically Disordered Protein TEX264 Mediates ER-phagy.

ZNF638 LETM1 RBMX

1.97e-0413130331006538
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

ZNF638 RPS26 GAR1 RBMXL1 RBMX

2.20e-0465230531180492
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ZNF638 ITCH WIPF2 RBMX

2.50e-0436030433111431
Pubmed

The full-ORF clone resource of the German cDNA Consortium.

MEF2B MIA2

2.68e-042830217974005
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ZNF638 TTBK2 SRCAP LETM1 RBMX EZHIP

2.83e-04108430611544199
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

RPRD2 ITCH WIPF2

3.17e-0415430316055720
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

ZNF638 RPS26 GAR1 RBMXL1 RBMX

3.33e-0471330529802200
Pubmed

Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.

RPRD2 SRCAP RBMX

3.35e-0415730330686591
Pubmed

GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma.

ITCH RBMXL1

3.74e-043330234841685
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

RPS26 RPS26P11 RBMXL2 GAR1 RBMXL1 RBMX

3.93e-04115330629845934
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

ZNF638 RPS26 ITCH GAR1 RBMXL1 RBMX

6.21e-04125730636526897
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

ZNF638 AGO4 RBMXL1 RBMX

6.41e-0446230431138677
Pubmed

Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.

GAR1 RBMX

7.27e-044630234767673
Pubmed

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer.

RPS26 LMTK3 RBMXL1

7.29e-0420530328927264
InteractionKIF20A interactions

ZNF638 RPS26 RPS26P11 RBMXL2 AGO4 MIA2 GAR1 RBMXL1 RBMX PKN3

1.16e-0610522910int:KIF20A
InteractionSH3GL2 interactions

SYN1 GCH1 ADAM19 ITCH

7.42e-0688294int:SH3GL2
InteractionRBMXL2 interactions

RBMXL2 RBMXL1 RBMX

2.55e-0540293int:RBMXL2
InteractionITSN2 interactions

SYN1 LMTK3 WIPF2 RBMX

5.60e-05147294int:ITSN2
GeneFamilyRNA binding motif containing

ZNF638 RBMXL2 RBMXL1 RBMX

9.58e-05213214725
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_1000

FNDC3A ITCH SRCAP MMP16 RBMX

3.98e-05277305gudmap_developingGonad_e12.5_ovary_k3_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_500

ITCH SRCAP MMP16 RBMX

7.66e-05162304gudmap_developingGonad_e16.5_epididymis_500_k2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

SYN1 FNDC3A RPRD2 ITCH SRCAP NRXN2

1.58e-04595306Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_2500_K4
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#4_top-relative-expression-ranked_200

ITCH MMP16 RBMX

1.67e-0476303gudmap_developingGonad_e16.5_epididymis_200_k4
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#2_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

2.08e-04210304gudmap_developingGonad_e18.5_ovary_1000_k2
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

2.71e-04225304gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#5_top-relative-expression-ranked_200

ITCH MMP16 RBMX

2.84e-0491303gudmap_developingGonad_e14.5_ epididymis_200_k5
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#2_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

2.95e-04230304gudmap_developingGonad_e16.5_ovary_1000_k2
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

3.98e-04249304gudmap_developingGonad_P2_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

4.62e-04259304gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

FNDC3A ITCH SRCAP MMP16

5.79e-04275304gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

6.27e-04281304gudmap_developingGonad_e18.5_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_1000

ITCH SRCAP MMP16 RBMX

6.53e-04284304gudmap_developingGonad_e16.5_epididymis_1000_k2
DrugPerhexiline maleate [6724-53-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

KMT2B GAR1 MMP16 CASKIN2 LETM1

5.24e-061953057441_DN
DrugNomifensine maleate [32795-47-4]; Down 200; 11.2uM; PC3; HT_HG-U133A

TTBK2 KMT2B SRCAP CASKIN2 LETM1

5.65e-061983052062_DN
DrugScopolamine hydrochloride [55-16-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A

TTBK2 RPRD2 MIA2 SRCAP WIPF2

5.79e-061993054803_DN
DiseaseDiamond-Blackfan anemia (implicated_via_orthology)

RPS26 RPS26P11

4.47e-0510302DOID:1339 (implicated_via_orthology)
Diseasedystonia (is_implicated_in)

GCH1 KMT2B

9.02e-0514302DOID:543 (is_implicated_in)
DiseaseDystonia, Limb

GCH1 KMT2B

1.35e-0417302C0751093
DiseaseDystonia, Diurnal

GCH1 KMT2B

1.35e-0417302C0393610
DiseaseDystonia, Paroxysmal

GCH1 KMT2B

1.51e-0418302C0393588
Diseaseautism spectrum disorder (implicated_via_orthology)

SYN1 MEF2B NRXN2

4.91e-04152303DOID:0060041 (implicated_via_orthology)
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

FNDC3A MMP16

1.01e-0346302EFO_0005325, HP_0012735
Diseaseschizophrenia, anorexia nervosa

RPRD2 MMP16

1.09e-0348302MONDO_0005090, MONDO_0005351
DiseaseCleft palate, cleft lip

GCH1 RPS26 MMP16

2.81e-03279303EFO_0003959, HP_0000175
Diseaseage of onset of asthma

RPS26 ADAM19

2.93e-0379302OBA_2001001
DiseaseDystonia

GCH1 KMT2B

3.46e-0386302C0013421
DiseaseInhalant adrenergic use measurement

RPS26 ADAM19

4.29e-0396302EFO_0009941

Protein segments in the cluster

PeptideGeneStartEntry
PRPRGGPEPLSPFPV

ERF

236

P50548
PRPPPDYLRGGSPPA

ADAM19

791

Q9H013
PGPPASLFQPPRRPG

AGO4

6

Q9HCK5
KPSFESGRRGPPPPP

RBMX

86

P38159
PLPVKRGPPPRSGGP

RBMX

146

P38159
RGPPPRSGGPPPKRS

RBMX

151

P38159
KPPGRRLFPEPLPPS

EZHIP

161

Q86X51
RLPPPPRYTVPRGSP

LETM1

16

O95202
PPLTLTPFPGPGPRR

LMTK3

1236

Q96Q04
GPGAPTSFEPRRPPP

NRXN2

1581

Q9P2S2
GRSPPAPPPYKAPRL

KMT2B

2286

Q9UMN6
GPKLAPRLGPRPVPP

CASKIN2

1116

Q8WXE0
RPSPFRPAAPKAGPP

MEF2B

166

Q02080
GGFKPSRPPRPSRPP

ITCH

246

Q96J02
PKLPPPPRGGRPQRL

GFY

491

I3L273
RLPPARPPTPGRSFP

GAS2L2

506

Q8NHY3
PPGPCLPPRLQGRPK

FNDC3A

661

Q9Y2H6
PPFARGPPFFAPKRP

RPRD2

1441

Q5VT52
RGPSPPASPTRKPPR

PKN3

541

Q6P5Z2
ARGPFLRRGPPFPPP

MIA2

1316

Q96PC5
RFLPRPPGEKGPPRG

GAR1

156

Q9NY12
PRPSGPGPAGRPKPQ

SYN1

621

P17600
PLPVKRGPPPRSGGP

RBMXL1

146

Q96E39
GFPERDPPRPGPSRP

GCH1

21

P30793
KRGRPPKNPPSPRPS

SRCAP

3006

Q6ZRS2
GPPPRRVGPPPKRAA

RBMXL2

151

O75526
AGPRPFPTPRARPPD

nan

16

P0C879
DRPKPPRPPTGRPSY

MMP16

321

P51512
PRPPTGRPSYPGAKP

MMP16

326

P51512
TPPPRFRPAGAAPRP

RPS26P11

96

Q5JNZ5
SQFFPRPPPGKPPTR

TTBK2

1071

Q6IQ55
RPPPGKPPTRPGVEA

TTBK2

1076

Q6IQ55
TPPPRFRPAGAAPRP

RPS26

96

P62854
SEPPSRGKPPPPPSR

WIPF2

351

Q8TF74
RPRAPNPSGMRPPGP

ZNF638

16

Q14966