Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	CEP350 AKAP5 ANK2 MAP1A EML4 CAPN6 KIF16B CLSTN1 TNNT3 SPATA32 DYNC1I1 IQGAP1	1.01e-05	1099	49	12	GO:0008092
GeneOntologyMolecularFunction	molecular adaptor activity	AKAP5 HDAC5 ANK2 MAP1A NACA KAT6A KSR2 HIPK2 SMARCE1 SRCAP STX16 AKAP12 IQGAP1	1.61e-05	1356	49	13	GO:0060090
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	HDAC5 ANK2 MAP1A NACA KAT6A KSR2 HIPK2 SMARCE1 SRCAP STX16 AKAP12 IQGAP1	1.74e-05	1160	49	12	GO:0030674
GeneOntologyMolecularFunction	microtubule binding	CEP350 MAP1A EML4 CAPN6 KIF16B DYNC1I1	1.03e-04	308	49	6	GO:0008017
GeneOntologyMolecularFunction	acetyltransferase activity	KAT6A SMARCE1 DBT SRCAP	1.23e-04	104	49	4	GO:0016407
GeneOntologyMolecularFunction	MAP-kinase scaffold activity	KSR2 IQGAP1	4.52e-04	13	49	2	GO:0005078
GeneOntologyMolecularFunction	tubulin binding	CEP350 MAP1A EML4 CAPN6 KIF16B DYNC1I1	6.00e-04	428	49	6	GO:0015631
GeneOntologyMolecularFunction	adenylate cyclase binding	AKAP5 AKAP12	6.93e-04	16	49	2	GO:0008179
GeneOntologyMolecularFunction	transcription coactivator activity	NACA KAT6A HIPK2 SMARCE1 SRCAP	8.59e-04	303	49	5	GO:0003713
GeneOntologyMolecularFunction	N-acetyltransferase activity	KAT6A SMARCE1 SRCAP	9.28e-04	78	49	3	GO:0008080
GeneOntologyMolecularFunction	glutamate receptor binding	AKAP5 MAP1A GRIN2B	1.04e-03	81	49	3	GO:0035254
GeneOntologyMolecularFunction	scaffold protein binding	CDC37 AKAP5 GRIN2B	1.54e-03	93	49	3	GO:0097110
GeneOntologyMolecularFunction	cytoskeletal anchor activity	ANK2 MAP1A	1.57e-03	24	49	2	GO:0008093
GeneOntologyMolecularFunction	N-acyltransferase activity	KAT6A SMARCE1 SRCAP	2.01e-03	102	49	3	GO:0016410
GeneOntologyMolecularFunction	transcription factor binding	CDC37 TAF3 HDAC5 NACA KAT6A HIPK2 SMARCE1	2.28e-03	753	49	7	GO:0008134
GeneOntologyMolecularFunction	histone modifying activity	UBR2 HDAC5 KAT6A SRCAP	2.38e-03	229	49	4	GO:0140993
GeneOntologyMolecularFunction	transcription coregulator activity	HDAC5 NACA KAT6A HIPK2 SMARCE1 SRCAP	2.42e-03	562	49	6	GO:0003712
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	KAT6A SMARCE1 DBT SRCAP	2.74e-03	238	49	4	GO:0016747
GeneOntologyMolecularFunction	spectrin binding	ANK2 DYNC1I1	3.15e-03	34	49	2	GO:0030507
GeneOntologyMolecularFunction	unfolded protein binding	CDC37 NACA2 NACA	3.66e-03	126	49	3	GO:0051082
GeneOntologyMolecularFunction	signaling adaptor activity	KSR2 AKAP12 IQGAP1	3.91e-03	129	49	3	GO:0035591
GeneOntologyBiologicalProcess	regulation of protein kinase A signaling	AKAP5 GRIN2B AKAP12	2.16e-05	23	49	3	GO:0010738
GeneOntologyCellularComponent	nascent polypeptide-associated complex	NACA2 NACA	5.36e-05	5	49	2	GO:0005854
GeneOntologyCellularComponent	postsynaptic density	AKAP5 ANK2 MAP1A ANKS1B GRIN2B CLSTN1 ADAM22	8.15e-05	451	49	7	GO:0014069
GeneOntologyCellularComponent	postsynapse	CHRNA6 AKAP5 ANK2 MAP1A SRGAP3 ANKS1B GRIN2B CLSTN1 USP48 ADAM22	1.04e-04	1018	49	10	GO:0098794
GeneOntologyCellularComponent	dendritic branch	MAP1A GRIN2B	1.12e-04	7	49	2	GO:0044307
GeneOntologyCellularComponent	asymmetric synapse	AKAP5 ANK2 MAP1A ANKS1B GRIN2B CLSTN1 ADAM22	1.16e-04	477	49	7	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	AKAP5 ANK2 MAP1A ANKS1B GRIN2B CLSTN1 ADAM22	1.60e-04	503	49	7	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	AKAP5 ANK2 MAP1A ANKS1B GRIN2B CLSTN1 ADAM22	2.04e-04	523	49	7	GO:0098984
GeneOntologyCellularComponent	postsynaptic density, intracellular component	AKAP5 ANKS1B GRIN2B	2.07e-04	49	49	3	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	AKAP5 ANKS1B GRIN2B	3.07e-04	56	49	3	GO:0099091
GeneOntologyCellularComponent	postsynaptic membrane	CHRNA6 ANK2 GRIN2B CLSTN1 USP48 ADAM22	3.52e-04	405	49	6	GO:0045211
GeneOntologyCellularComponent	synaptic membrane	CHRNA6 AKAP5 ANK2 GRIN2B CLSTN1 USP48 ADAM22	3.93e-04	583	49	7	GO:0097060
GeneOntologyCellularComponent	microtubule	MAP1A EML4 CAPN6 KIF16B DYNC1I1 IQGAP1	1.47e-03	533	49	6	GO:0005874
GeneOntologyCellularComponent	supramolecular fiber	ANK2 MAP1A EML4 CAPN6 KIF16B GRIN2B TNNT3 DYNC1I1 IQGAP1	1.49e-03	1179	49	9	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	ANK2 MAP1A EML4 CAPN6 KIF16B GRIN2B TNNT3 DYNC1I1 IQGAP1	1.56e-03	1187	49	9	GO:0099081
GeneOntologyCellularComponent	postsynaptic endosome	AKAP5 CLSTN1	1.69e-03	26	49	2	GO:0098845
GeneOntologyCellularComponent	axon initial segment	MAP1A ADAM22	2.10e-03	29	49	2	GO:0043194
GeneOntologyCellularComponent	dendritic spine	AKAP5 ANKS1B GRIN2B CLSTN1	2.47e-03	242	49	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	AKAP5 ANKS1B GRIN2B CLSTN1	2.66e-03	247	49	4	GO:0044309
Domain	Pkinase-A_anch_WSK-motif	AKAP5 AKAP12	6.47e-06	2	48	2	IPR001573
Domain	WSK	AKAP5 AKAP12	6.47e-06	2	48	2	PF03832
Domain	EGD2/NACA	NACA2 NACA	1.94e-05	3	48	2	IPR016641
Domain	NAC	NACA2 NACA	6.44e-05	5	48	2	SM01407
Domain	VCX/VCY1	VCX2 VCX3B	6.44e-05	5	48	2	IPR026653
Domain	VCX_VCY	VCX2 VCX3B	6.44e-05	5	48	2	PF15231
Domain	NAC	NACA2 NACA	9.64e-05	6	48	2	PF01849
Domain	Nas_poly-pep-assoc_cplx_dom	NACA2 NACA	9.64e-05	6	48	2	IPR002715
Domain	NAC_AB	NACA2 NACA	9.64e-05	6	48	2	PS51151
Domain	Rho_GTPase_activation_prot	ARHGAP31 SRGAP3 IQGAP1	1.50e-03	88	48	3	IPR008936
Domain	UBIQUITIN_1	USP48 IQUB	4.07e-03	37	48	2	PS00299
Domain	UBA	NACA2 NACA	6.49e-03	47	48	2	PS50030
Domain	WW	WBP4 IQGAP1	6.49e-03	47	48	2	PF00397
Domain	WW	WBP4 IQGAP1	6.77e-03	48	48	2	SM00456
Domain	WW_DOMAIN_2	WBP4 IQGAP1	7.61e-03	51	48	2	PS50020
Domain	WW_DOMAIN_1	WBP4 IQGAP1	7.61e-03	51	48	2	PS01159
Domain	WW_dom	WBP4 IQGAP1	7.90e-03	52	48	2	IPR001202
Domain	UBIQUITIN_2	USP48 IQUB	8.50e-03	54	48	2	PS50053
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	ANK2 MAP1A SRGAP3 ANKS1B GRIN2B ADAM22 DYNC1I1 IQGAP1	7.75e-09	281	51	8	28706196
Pubmed	A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.	AKAP5 AKAP12	2.11e-06	2	51	2	25637608
Pubmed	G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential trafficking and distribution.	AKAP5 AKAP12	2.11e-06	2	51	2	18950703
Pubmed	Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.	NACA2 NACA	2.11e-06	2	51	2	12406326
Pubmed	The CDC37-HSP90 chaperone complex co-translationally degrades the nascent kinase-dead mutant of HIPK2.	CDC37 HIPK2	6.32e-06	3	51	2	33786814
Pubmed	Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1α under hypoxia condition.	HDAC5 HIPK2	6.32e-06	3	51	2	28653891
Pubmed	Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.	VCX2 VCX3B	6.32e-06	3	51	2	18076704
Pubmed	Identification of an IQGAP1/AKAP79 complex in beta-cells.	AKAP5 IQGAP1	6.32e-06	3	51	2	12938160
Pubmed	The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions.	NACA2 NACA	6.32e-06	3	51	2	10982809
Pubmed	The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit .	NACA2 NACA	6.32e-06	3	51	2	20214399
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	ANK2 NACA ANKS1B GRIN2B ADAM22	1.05e-05	197	51	5	36604605
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	ANK2 MAP1A SRGAP3 GRIN2B STX16 ADAM22	1.17e-05	347	51	6	17114649
Pubmed	Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts.	AKAP5 AKAP12	1.26e-05	4	51	2	17081159
Pubmed	ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization.	ANKS1B GRIN2B	1.26e-05	4	51	2	26085624
Pubmed	A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.	VCX2 VCX3B	1.26e-05	4	51	2	10903929
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 ZBTB44 MIA2 ANK2 ANKS1B SMARCE1 GRIN2B ADAM22 DYNC1I1 IQGAP1	1.47e-05	1285	51	10	35914814
Pubmed	An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics.	AKAP5 AKAP12	3.15e-05	6	51	2	16642035
Pubmed	Phosphodiesterase 10A Is Tethered to a Synaptic Signaling Complex in Striatum.	AKAP5 GRIN2B	3.15e-05	6	51	2	25762721
Pubmed	HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.	CDC37 KSR2	3.15e-05	6	51	2	27086506
Pubmed	MEK drives BRAF activation through allosteric control of KSR proteins.	CDC37 KSR2	4.41e-05	7	51	2	29433126
Pubmed	Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.	MAP1A GRIN2B	4.41e-05	7	51	2	33000527
Pubmed	Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.	MAP1A GRIN2B	5.87e-05	8	51	2	26609151
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CDC37 ANK2 MAP1A NACA SMARCE1 SRCAP AKAP12 NOL8	6.01e-05	934	51	8	33916271
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	SMARCE1 SRCAP USP48 ZMYM3	7.09e-05	150	51	4	28242625
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANK2 SRGAP3 KSR2 ANKS1B GRIN2B ADAM22 AKAP12 IQGAP1	7.44e-05	963	51	8	28671696
Pubmed	Anchoring and scaffold proteins for kinases and phosphatases.	AKAP5 AKAP12	7.54e-05	9	51	2	9238861
Pubmed	TBR1 regulates autism risk genes in the developing neocortex.	ANK2 GRIN2B	7.54e-05	9	51	2	27325115
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	HDAC5 KAT6A SMARCE1 SRCAP	8.47e-05	157	51	4	30186101
Pubmed	AKAP mediated signal transduction.	AKAP5 AKAP12	9.42e-05	10	51	2	11807172
Pubmed	Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.	ARHGAP31 DYNC1I1	1.15e-04	11	51	2	18331715
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	NCAPD2 SRCAP USP48 ZMYM3 IQGAP1	1.26e-04	332	51	5	32786267
Pubmed	p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.	MAP1A ANKS1B	1.38e-04	12	51	2	16537434
Pubmed	DEC1 represses cardiomyocyte hypertrophy by recruiting PRP19 as an E3 ligase to promote ubiquitination-proteasome-mediated degradation of GATA4.	TAF3 EML4	1.63e-04	13	51	2	35659652
Pubmed	Interaction network of human early embryonic transcription factors.	TAF3 HDAC5 SMARCE1 DBT ZMYM3	1.63e-04	351	51	5	38297188
Pubmed	Large-scale concatenation cDNA sequencing.	CEP350 DMTF1 ANK2 EML4 HIPK2 RNF13	1.78e-04	568	51	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	CEP350 DMTF1 ANK2 EML4 HIPK2 RNF13	1.89e-04	574	51	6	8619474
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TAF3 MAP1A SH3TC1 KAT6A SMARCE1 DBT SRCAP ZMYM3	2.05e-04	1116	51	8	31753913
Pubmed	Human transcription factor protein interaction networks.	CDC37 TAF3 HDAC5 NACA HIPK2 SMARCE1 DBT SRCAP ZMYM3	2.08e-04	1429	51	9	35140242
Pubmed	The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue.	MAP1A DBT DYNC1I1	2.17e-04	79	51	3	25921334
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	ANK2 MAP1A SRGAP3 NACA ANKS1B GRIN2B DBT ADAM22	2.35e-04	1139	51	8	36417873
Pubmed	Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.	CAPN6 TFPI	2.50e-04	16	51	2	14743444
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	TAF3 KAT6A SMARCE1 SRCAP USP48 ZMYM3	2.57e-04	608	51	6	36089195
Pubmed	Identification of a polymorphic, neuron-specific chromatin remodeling complex.	SRGAP3 SMARCE1	2.83e-04	17	51	2	12368262
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	CDC37 MIA2 NCAPD2 SMARCE1 IQGAP1	2.95e-04	399	51	5	37536630
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	AKAP5 ANK2 MAP1A GRIN2B ADAM22	3.09e-04	403	51	5	30562941
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	CEP350 CDC37 HDAC5 SMARCE1 AKAP12 IQGAP1	3.35e-04	639	51	6	23443559
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CDC37 UBR2 MIA2 SMARCE1 CLSTN1 USP48 ADAM22 TFPI	3.36e-04	1201	51	8	35696571
Pubmed	Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.	HDAC5 SMARCE1	3.55e-04	19	51	2	16919237
Pubmed	Emergence of young human genes after a burst of retroposition in primates.	NACA2 NACA	3.94e-04	20	51	2	16201836
Pubmed	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.	CDC37 IQGAP1	3.94e-04	20	51	2	22504172
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	DMTF1 MIA2 HDAC5 MAP1A ARHGAP31	4.15e-04	430	51	5	35044719
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	UBR2 SRCAP ZMYM3	4.87e-04	104	51	3	9205841
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	ANK2 ANKS1B GRIN2B ADAM22	5.07e-04	251	51	4	27507650
Pubmed	The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.	DYNC1I1 IQGAP1	6.19e-04	25	51	2	15121898
Pubmed	Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.	GRIN2B ADAM22	7.23e-04	27	51	2	24550280
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	CDC37 UBR2 NACA AKAP12 IQGAP1	7.77e-04	494	51	5	26831064
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	HDAC5 GRIN2B	7.78e-04	28	51	2	31600191
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CEP350 TAF3 ANK2 EML4 NACA SMARCE1 IQGAP1 TFPI	8.04e-04	1371	51	8	36244648
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ARHGAP31 NACA KIF16B NCAPD2 IQGAP1	1.05e-03	529	51	5	14621295
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ANK2 MAP1A SRGAP3 ANKS1B GRIN2B ADAM22 DYNC1I1 IQGAP1	1.06e-03	1431	51	8	37142655
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	AKAP5 MIA2 ANK2 NCAPD2 ANKS1B SRCAP DYNC1I1 IQGAP1	1.11e-03	1442	51	8	35575683
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	CDC37 NACA	1.15e-03	34	51	2	16611982
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	CDC37 MAP1A EML4 IQGAP1	1.35e-03	327	51	4	15592455
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CDC37 AKAP5 ANK2 KIF16B DBT USP48 AKAP12 NOL8	1.36e-03	1487	51	8	33957083
Pubmed	Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.	ANK2 EML4	1.36e-03	37	51	2	27565344
Pubmed	Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.	CEP350 CDC37	1.43e-03	38	51	2	36674791
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	ANK2 SRGAP3 SMARCE1	1.43e-03	151	51	3	17043677
Interaction	AGAP2 interactions	ANK2 MAP1A SRGAP3 ANKS1B GRIN2B DYNC1I1 IQGAP1	8.25e-07	210	50	7	int:AGAP2
Interaction	FAM153CP interactions	FAM153B FAM153A MAP1A	2.34e-06	11	50	3	int:FAM153CP
Interaction	ROPN1 interactions	CDC37 FAM153B AKAP5 FAM153A	1.58e-05	61	50	4	int:ROPN1
Interaction	DCTN1 interactions	CEP350 CDC37 MAP1A EML4 NACA NCAPD2 USP48 DYNC1I1	2.79e-05	497	50	8	int:DCTN1
Interaction	FAM153B interactions	FAM153B FAM153A MAP1A	4.51e-05	28	50	3	int:FAM153B
Cytoband	7q21	DMTF1 ADAM22	9.36e-05	13	51	2	7q21
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	DMTF1 ADAM22 DYNC1I1	1.04e-03	178	51	3	chr7q21
Cytoband	Ensembl 112 genes in cytogenetic band chr14q21	MIA2 FSCB	5.27e-03	97	51	2	chr14q21
Cytoband	Ensembl 112 genes in cytogenetic band chr8p11	CHRNA6 KAT6A	5.92e-03	103	51	2	chr8p11
GeneFamily	Variable charge X/Y family	VCX2 VCX3B	4.53e-05	6	32	2	368
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP5 AKAP12	1.20e-03	29	32	2	396
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP31 SRGAP3	3.53e-03	50	32	2	721
GeneFamily	PHD finger proteins	TAF3 KAT6A	1.10e-02	90	32	2	88
Coexpression	CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN	DMTF1 AKAP5 MIA2 SRGAP3 DBT CLSTN1 AKAP12	1.16e-05	407	50	7	M2214
Coexpression	GSE34205_HEALTHY_VS_RSV_INF_INFANT_PBMC_UP	TAF3 NACA HIPK2 CLSTN1 AKAP12	3.41e-05	194	50	5	M5136
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN	DMTF1 HDAC5 SH3TC1 EML4 IQGAP1	3.94e-05	200	50	5	M9459
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MIA2 EML4 KAT6A AKAP12 IQGAP1	6.25e-08	182	51	6	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MIA2 EML4 KAT6A AKAP12 IQGAP1	6.66e-08	184	51	6	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MIA2 EML4 KAT6A AKAP12 IQGAP1	6.88e-08	185	51	6	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 FSCB ADAM22 IQUB	1.96e-06	180	51	5	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B ADAM22 IQUB	2.07e-06	182	51	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAM153A KSR2 GRIN2B ADAM22 IQUB	2.13e-06	183	51	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B ADAM22 IQUB	2.36e-06	187	51	5	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B ADAM22 IQUB	2.36e-06	187	51	5	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B ADAM22 IQUB	2.49e-06	189	51	5	3a295c215b5c18e7c673f92b7af5be523421682c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B ADAM22 IQUB	2.56e-06	190	51	5	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP5 ANK2 MAP1A ANKS1B RNF13	2.83e-06	194	51	5	ba529c051f248d29f4222f4bc9801ba233859093
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KSR2 ANKS1B GRIN2B ADAM22 DYNC1I1	2.98e-06	196	51	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KSR2 ANKS1B GRIN2B ADAM22 DYNC1I1	3.13e-06	198	51	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	CEP350 TAF3 HIPK2 SMARCE1 RNF13	3.13e-06	198	51	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KSR2 ANKS1B GRIN2B ADAM22 DYNC1I1	3.13e-06	198	51	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KSR2 ANKS1B GRIN2B ADAM22 DYNC1I1	3.13e-06	198	51	5	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KSR2 ANKS1B GRIN2B ADAM22 DYNC1I1	3.13e-06	198	51	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	KSR2 ANKS1B GRIN2B ADAM22 DYNC1I1	3.28e-06	200	51	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Tracheal-10x5prime-Stromal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 MAP1A PRG4 AKAP12 TFPI	3.28e-06	200	51	5	920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCell	COVID-19-lung-Mesothelial\|lung / Disease (COVID-19 only), tissue and cell type	FAM153B FAM153A ANKS1B PRG4	3.06e-05	156	51	4	e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCell	normal_Pleural_Fluid-T/NK_cells-CD4+_Th\|normal_Pleural_Fluid / Location, Cell class and cell subclass	AKAP5 ANK2 ANKS1B SMARCE1	3.30e-05	159	51	4	ebd840ac2b07e62086ee7b5bb01c21804a0fdc7b
ToppCell	COVID-19-lung-Mesothelial\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAM153B FAM153A ANKS1B PRG4	3.72e-05	164	51	4	83303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3TC1 CLSTN1 AKAP12 TFPI	4.58e-05	173	51	4	fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	GRIN2B DYNC1I1 AKAP12 TFPI	4.90e-05	176	51	4	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	GRIN2B DYNC1I1 AKAP12 TFPI	4.90e-05	176	51	4	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FAM153B FAM153A ANK2 TFPI	5.01e-05	177	51	4	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	GRIN2B DYNC1I1 AKAP12 TFPI	5.12e-05	178	51	4	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B IQUB	5.35e-05	180	51	4	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SRGAP3 GRIN2B AKAP12 TFPI	5.46e-05	181	51	4	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	SRGAP3 GRIN2B AKAP12 TFPI	5.46e-05	181	51	4	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	droplet-Marrow-nan-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 MIA2 ARHGAP31 EML4	5.58e-05	182	51	4	bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 ADAM22 IQUB	5.95e-05	185	51	4	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	GRIN2B DYNC1I1 AKAP12 TFPI	5.95e-05	185	51	4	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	GRIN2B DYNC1I1 AKAP12 TFPI	5.95e-05	185	51	4	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 ADAM22 IQUB	5.95e-05	185	51	4	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B IQUB	6.07e-05	186	51	4	aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CHRNA6 SH3TC1 SRGAP3 WBP4	6.07e-05	186	51	4	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	KSR2 GRIN2B CLSTN1 DYNC1I1	6.07e-05	186	51	4	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SRGAP3 HIPK2 STX16 ZMYM3	6.20e-05	187	51	4	0099def970fbc828756fbf853eca2ce77b8cd342
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 ADAM22 IQUB	6.20e-05	187	51	4	f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCell	10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	AKAP5 EML4 SRGAP3 CCDC168	6.20e-05	187	51	4	f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCell	moderate-Epithelial-Ionocyte\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FAM153B FAM153A ANK2 TFPI	6.20e-05	187	51	4	3e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIN2B DYNC1I1 AKAP12 TFPI	6.33e-05	188	51	4	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIN2B DYNC1I1 AKAP12 TFPI	6.33e-05	188	51	4	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B ADAM22	6.46e-05	189	51	4	c9565e962a13a7713056ec3dbb1b67d24f9889c7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 ADAM22 IQUB	6.46e-05	189	51	4	fc88c51ace7d883c01617f3f9b5fab70cc91cc09
ToppCell	COVID-19-lung-Lymphatic_EC\|lung / Disease (COVID-19 only), tissue and cell type	GRIN2B DYNC1I1 AKAP12 TFPI	6.46e-05	189	51	4	c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B IQUB	6.46e-05	189	51	4	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B IQUB	6.59e-05	190	51	4	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	GRIN2B DYNC1I1 AKAP12 TFPI	6.59e-05	190	51	4	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRIN2B DYNC1I1 AKAP12 TFPI	6.59e-05	190	51	4	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SRGAP3 KSR2 GRIN2B IQUB	6.59e-05	190	51	4	078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 KSR2 ANKS1B DYNC1I1	6.87e-05	192	51	4	2f1c4ef693515ccc7231bd8c6641fad51d445d20
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	SH3TC1 EML4 AKAP12 IQGAP1	6.87e-05	192	51	4	8b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	ANK2 SRGAP3 ANKS1B ADAM22	6.87e-05	192	51	4	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ANK2 HIPK2 AKAP12 TFPI	6.87e-05	192	51	4	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 UBR2 KAT6A HIPK2	6.87e-05	192	51	4	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP5 MAP1A ANKS1B RNF13	7.01e-05	193	51	4	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AKAP5 MIA2 AKAP12 TFPI	7.01e-05	193	51	4	ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 CAPN6 GRIN2B TNNT3	7.15e-05	194	51	4	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRIN2B DYNC1I1 AKAP12 TFPI	7.15e-05	194	51	4	f772a9f9ef8635aeaeb8b022dbb94e9672b36ead
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SRGAP3 ANKS1B ADAM22 DYNC1I1	7.15e-05	194	51	4	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	(4)_Endothelial_cells-(4)_Lymph_vessel\|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	SRGAP3 DYNC1I1 AKAP12 TFPI	7.15e-05	194	51	4	9735b86d3b2480a0b34d8aab8e7bd609d83c2454
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRIN2B DYNC1I1 AKAP12 TFPI	7.15e-05	194	51	4	5d2b3ed5374e2ab10c1c7eb3a03139fc95036a48
ToppCell	nucseq-Endothelial-Endothelial_Lymphatic-LEC-LEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GRIN2B DYNC1I1 AKAP12 TFPI	7.15e-05	194	51	4	3b73f2d305a7566f7ab567e5f18c82cd3d80e32c
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KSR2 GRIN2B CLSTN1 DYNC1I1	7.15e-05	194	51	4	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	SRGAP3 DYNC1I1 AKAP12 TFPI	7.29e-05	195	51	4	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	IPF-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	SRGAP3 GRIN2B AKAP12 TFPI	7.29e-05	195	51	4	de88e9d22044b4b3e29676ad02b3e9299cc920ad
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SRGAP3 ANKS1B ADAM22 DYNC1I1	7.29e-05	195	51	4	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP31 GRIN2B AKAP12 TFPI	7.44e-05	196	51	4	09a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCell	primary_visual_cortex-Neuronal\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKS1B GRIN2B CLSTN1 DYNC1I1	7.44e-05	196	51	4	8efc2b3a95f57c31be203ac781b2098d4909297f
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP31 GRIN2B AKAP12 TFPI	7.44e-05	196	51	4	e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCell	frontal_cortex-Neuronal\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKS1B GRIN2B CLSTN1 DYNC1I1	7.44e-05	196	51	4	de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GRIN2B DYNC1I1 AKAP12 TFPI	7.73e-05	198	51	4	b3a020522e064bb61949d38e442f24026e339364
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK2 MAP1A HIPK2 RNF13	7.73e-05	198	51	4	fef9a4c96450078527b94d25e681410e4ea01b13
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_lymphatic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GRIN2B DYNC1I1 AKAP12 TFPI	7.73e-05	198	51	4	fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KSR2 GRIN2B ADAM22 DYNC1I1	7.73e-05	198	51	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	18-Airway-Mesenchymal-Mesenchyme_RSPO2+\|Airway / Age, Tissue, Lineage and Cell class	NCAPD2 ANKS1B AKAP12 TFPI	7.89e-05	199	51	4	7ac35e8f45dcdc702422dabd8f3e4d03e2bf61af
ToppCell	18-Distal-Mesenchymal-Mesenchyme_RSPO2+\|Distal / Age, Tissue, Lineage and Cell class	ANKS1B DYNC1I1 AKAP12 TFPI	7.89e-05	199	51	4	95403988caef322314f4ed15415ad1a9a987adc1
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	TAF3 HIPK2 SMARCE1 IQGAP1	7.89e-05	199	51	4	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	CEP350 HIPK2 SMARCE1 IQGAP1	7.89e-05	199	51	4	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Sepsis-Bac-SEP-Lymphocyte-T/NK-Treg\|Bac-SEP / Disease, condition lineage and cell class	FAM153B FAM153A SRGAP3 ANKS1B	7.89e-05	199	51	4	e0b6136e28b813299b7ffbe37f1cf830e60cd7d8
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	MAP1A ANKS1B ADAM22 AKAP12	8.04e-05	200	51	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 MAP1A PRG4 TFPI	8.04e-05	200	51	4	74ad0ae592252060ee294d7483327d765a6ba1dd
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GRIN2B DYNC1I1 AKAP12 TFPI	8.04e-05	200	51	4	c59f262b2b0a7e7dcb2940d1e466f98db6c56625
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GRIN2B DYNC1I1 AKAP12 TFPI	8.04e-05	200	51	4	e50ef394e3284a8323bfd60575b262b2be422aea
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Cortical_neuron\|6m / Sample Type, Dataset, Time_group, and Cell type.	ANK2 ANKS1B GRIN2B DYNC1I1	8.04e-05	200	51	4	6f7ff0533339fcc9d316f2c77334a79c1409ec4f
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ANK2 MAP1A PRG4 TFPI	8.04e-05	200	51	4	7ba292c30d915e66ebc8026fa76492cedf64700e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KSR2 GRIN2B IQUB	3.42e-04	119	51	3	0cebbd44378c212aa0e18e4303f09eb315d02e11
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Myxofibrosarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	TNNT3 PRG4 TFPI	4.54e-04	131	51	3	c847dcdfb94feb9e1dfc072a162d2b1b6f3d59e4
ToppCell	RV-14._Fibroblast_III\|RV / Chamber and Cluster_Paper	ANKS1B PRG4 TFPI	5.50e-04	140	51	3	b4fee8eb6bf855b364b00bda3f78e49d851bbca0
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-4\|TCGA-Cervix / Sample_Type by Project: Shred V9	MAP1A KSR2 IQUB	5.74e-04	142	51	3	369f2e51e0283a4de70e6c7a3b95672c0838f205
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KSR2 GRIN2B IQUB	6.34e-04	147	51	3	64fa0753a3a79f492ef8acc6942bf90d379a983f
ToppCell	3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	SRGAP3 CCDC168 TFPI	6.60e-04	149	51	3	d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	CHRNA6 SH3TC1 SRGAP3	6.60e-04	149	51	3	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CHRNA6 SRGAP3 PRG4	6.86e-04	151	51	3	0b6b37734430918378ed94e40877f0c4ae9b25ec
ToppCell	Severe_COVID-19-undefined\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FAM153A ADAM22 AKAP12	6.86e-04	151	51	3	2ae403417fcb3fe402f6f47bb60ffa68d5fefd2a
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHRNA6 SRGAP3 PRG4	6.86e-04	151	51	3	30225a1a7800b0ae19e16ac164f561379eedb99d
ToppCell	Bac-SEP-Lymphocyte-T_NK-Treg\|Bac-SEP / Disease, Lineage and Cell Type	FAM153B SRGAP3 ANKS1B	6.86e-04	151	51	3	5df5e754a45b8a592ca7ad49a70953be1615066a
ToppCell	Severe_COVID-19-undefined-undefined\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FAM153A ADAM22 AKAP12	6.86e-04	151	51	3	b402185dd7a93c6d0ec5c4d84d5031a157ee8cfb
Drug	0173570-0000 [211245-44-2]; Down 200; 10uM; MCF7; HT_HG-U133A	ZBTB44 MIA2 HDAC5 KAT6A ADAM22 TFPI	4.78e-06	195	51	6	4712_DN
Drug	Deltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A	ZBTB44 HDAC5 SRCAP USP48 ADAM22 AKAP12	5.06e-06	197	51	6	3831_DN
Drug	Folinic acid calcium salt [6035-45-6]; Down 200; 7.8uM; MCF7; HT_HG-U133A	ZBTB44 HDAC5 KAT6A HIPK2 SRCAP ADAM22	5.37e-06	199	51	6	4725_DN
Drug	anacardic acid	NACA2 HDAC5 KAT6A	4.12e-05	30	51	3	CID000167551
Drug	Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; MCF7; HT_HG-U133A	HDAC5 SH3TC1 HIPK2 SRCAP ADAM22	5.53e-05	183	51	5	4732_UP
Drug	Levonordefrin [829-74-3]; Up 200; 21.8uM; PC3; HT_HG-U133A	MIA2 MAP1A ADAM22 AKAP12 TFPI	6.13e-05	187	51	5	5854_UP
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	CEP350 HIPK2 DBT STX16 IQGAP1	6.28e-05	188	51	5	6735_DN
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A	CEP350 KAT6A HIPK2 STX16 IQGAP1	6.44e-05	189	51	5	6649_DN
Drug	Cyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A	WBP4 KAT6A HIPK2 ADAM22 AKAP12	7.29e-05	194	51	5	4411_DN
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; PC3; HT_HG-U133A	CEP350 DBT STX16 ZMYM3 DYNC1I1	7.65e-05	196	51	5	5881_DN
Drug	Benzonatate [104-31-4]; Down 200; 6.6uM; MCF7; HT_HG-U133A	KAT6A HIPK2 DBT AKAP12 TFPI	7.65e-05	196	51	5	5435_DN
Drug	Pipenzolate bromide [125-51-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A	ZBTB44 MIA2 SRGAP3 KAT6A ADAM22	7.65e-05	196	51	5	6821_UP
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; MCF7; HT_HG-U133A	KAT6A CLSTN1 USP48 ADAM22 TFPI	7.65e-05	196	51	5	3429_DN
Drug	Beclomethasone dipropionate [5534-09-8]; Down 200; 7.6uM; MCF7; HT_HG-U133A	KAT6A HIPK2 SRCAP ADAM22 AKAP12	7.65e-05	196	51	5	4403_DN
Drug	Ramipril [87333-19-5]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CEP350 KIF16B DBT SRCAP USP48	7.84e-05	197	51	5	6792_DN
Drug	Dipyridamole [58-32-2]; Up 200; 8uM; MCF7; HT_HG-U133A	ZBTB44 AKAP5 MAP1A SRCAP ADAM22	7.84e-05	197	51	5	5252_UP
Drug	0225151-0000 [351320-15-5]; Up 200; 10uM; MCF7; HT_HG-U133A	HIPK2 GRIN2B DBT SRCAP ADAM22	8.03e-05	198	51	5	6384_UP
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Up 200; 7.6uM; MCF7; HT_HG-U133A	CHRNA6 MIA2 HDAC5 SRCAP ADAM22	8.03e-05	198	51	5	2845_UP
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; MCF7; HT_HG-U133A	HDAC5 SH3TC1 SRCAP USP48 ADAM22	8.03e-05	198	51	5	3895_DN
Drug	Nitrofurantoin [67-20-9]; Down 200; 16.8uM; PC3; HT_HG-U133A	ZBTB44 MAP1A KIF16B USP48 DYNC1I1	8.22e-05	199	51	5	7373_DN
Drug	Acetazolamide [59-66-5]; Up 200; 18uM; MCF7; HT_HG-U133A	ZBTB44 AKAP5 MAP1A SRCAP ADAM22	8.22e-05	199	51	5	7461_UP
Drug	Mafenide hydrochloride [138-37-4]; Up 200; 18uM; MCF7; HT_HG-U133A	MAP1A SRGAP3 HIPK2 ADAM22 IQGAP1	8.22e-05	199	51	5	2287_UP
Drug	Papaverine hydrochloride [61-25-6]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CHRNA6 MAP1A SRGAP3 KAT6A TNNT3	8.22e-05	199	51	5	2747_UP
Drug	Nalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; PC3; HT_HG-U133A	DMTF1 HDAC5 MAP1A HIPK2 USP48	8.42e-05	200	51	5	2063_DN
Drug	nocodazole	CEP350 MAP1A EML4 CAPN6 ANKS1B AKAP12 IQGAP1	8.85e-05	477	51	7	CID000004122
Disease	Neurodevelopmental Disorders	ANK2 SRGAP3 GRIN2B SRCAP	1.91e-05	93	50	4	C1535926
Disease	xanthine measurement	KSR2 ADAM22	2.17e-04	13	50	2	EFO_0010548
Disease	Adenoid Cystic Carcinoma	KAT6A SMARCE1 SRCAP	6.59e-04	100	50	3	C0010606
Disease	Brain Tumor, Primary	EML4 IQGAP1	1.44e-03	33	50	2	C0750974
Disease	Primary malignant neoplasm of brain	EML4 IQGAP1	1.44e-03	33	50	2	C0750979
Disease	Recurrent Brain Neoplasm	EML4 IQGAP1	1.44e-03	33	50	2	C0750977
Disease	Neoplasms, Intracranial	EML4 IQGAP1	1.44e-03	33	50	2	C1527390
Disease	Benign neoplasm of brain, unspecified	EML4 IQGAP1	1.44e-03	33	50	2	C0496899
Disease	Malignant neoplasm of brain	EML4 IQGAP1	1.90e-03	38	50	2	C0153633
Disease	Brain Neoplasms	EML4 IQGAP1	2.00e-03	39	50	2	C0006118
Disease	Malignant neoplasm of breast	MIA2 ANK2 SRGAP3 WBP4 KIF16B FSCB AKAP12	2.11e-03	1074	50	7	C0006142
Disease	revision of total hip arthroplasty, aseptic loosening	VCX2 VCX3B	2.32e-03	42	50	2	EFO_0010725, EFO_0020973
Disease	developmental disorder of mental health (implicated_via_orthology)	GRIN2B SRCAP	3.15e-03	49	50	2	DOID:0060037 (implicated_via_orthology)
Disease	neuropsychological test	VCX2 GRIN2B VCX3B	4.56e-03	197	50	3	EFO_0003926

Protein segments in the cluster

Peptide	Gene	Start	Entry
VHDITDDGQEETPEI	AKAP12	131	Q02952
HTYLIEPEENDTTQE	ADAM22	166	Q9P0K1
DPTVQESLVSEEIVH	CLSTN1	701	O94985
PTIEEQVDQTIDDET	DMTF1	681	Q9Y222
EILETPATSEQEAEH	IQGAP1	1406	P46940
EKHDESVTDVTEVPQ	KIF16B	876	Q96L93
VQSVPEEESHRESEV	ANK2	2096	Q01484
EPVQEDATQETHISS	ANKS1B	296	Q7Z6G8
SEEDVVETPAVSHDE	DBT	146	P11182
EEIENTSSVQIIEEH	HIPK2	136	Q9H2X6
TEQTISDEEIHDEPE	MAP1A	746	P78559
AEETHVQVQPSTEET	FSCB	286	Q5H9T9
EVEPTSENEEVHDEA	KSR2	611	Q6VAB6
QTPLATHQSEEDEED	DYNC1I1	171	O14576
SDLEDLEEHVPEQTV	FAM153A	211	Q9UHL3
LEEHVPEQTVSEEAT	FAM153A	216	Q9UHL3
ETEETSTQEQSHPGE	NOL8	806	Q76FK4
KEETELDSEEEQPSH	KAT6A	1366	Q92794
LDSEEEQPSHDTSVV	KAT6A	1371	Q92794
ENSEHSPEVEDVINS	CHRNA6	421	Q15825
EVSDDEDETHPNIDT	CDC37	11	Q16543
SDVEHEQQVTESPSL	CEP350	2471	Q5VT06
ETSETDHQQPVLSDV	AKAP5	251	P24588
PQESDQTEEHESGIE	IQUB	36	Q8NA54
SLEQTVEPSEDHSEE	EML4	926	Q9HC35
GHITEEEEEVQENSP	CCDC168	2341	Q8NDH2
TTHPEETEEELTEQQ	HDAC5	546	Q9UQL6
SIESPNQEEQEVETD	CAPN6	231	Q9Y6Q1
EDLEEHVPGQTVSEE	FAM153B	291	P0C7A2
EPQTEHQQESESEID	MIA2	271	Q96PC5
IVSSQEEEEEEQVPT	TAF3	131	Q5VWG9
QESEVEEPLSQESEV	VCX3B	156	Q9H321
ETEETHLEETTESQQ	SMARCE1	341	Q969G3
TDSSQEENEVTEHTP	RNF13	296	O43567
LTTVEEREPENHAET	SPATA32	281	Q96LK8
PSEEEETAIQVHVDE	SH3TC1	181	Q8TE82
PEEEEETVASKQTHI	SRCAP	2226	Q6ZRS2
SEEITEEHSVSENQE	PRG4	151	Q92954
EEIPEQIANTETTED	NCAPD2	501	Q15021
QESEVEEPLSQESEV	VCX2	106	Q9H322
EPHTSDEEVEQIEAI	SRGAP3	736	O43295
SEEEHAIEITTQEIT	STX16	116	O14662
DEEVHEEVSQPVSAS	ZBTB44	296	Q8NCP5
SHEEVDLELPSTENE	WBP4	306	O75554
VSQEEEDVTHSVQEP	ARHGAP31	871	Q2M1Z3
EEDEEHTIITDTELP	TFPI	31	P10646
VHEEVHEPEEVQEDT	TNNT3	26	P45378
HELNTSEIEEEEDPL	UBR2	166	Q8IWV8
ETVRPEEVSQEHIET	USP48	16	Q86UV5
TLQSPHIEEEETTSI	ZMYM3	151	Q14202
NTQTPTVQEESEEEE	NACA2	156	Q9H009
QTPTVQEESEEEEVD	NACA	2021	E9PAV3
NTQTPTVQEESEEEE	NACA	156	Q13765
PETEEQEDDHLSIVT	GRIN2B	396	Q13224