Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX ATP2A1 DNAH6	2.69e-07	441	42	9	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX ATP2A1 DNAH6	4.17e-06	614	42	9	GO:0140657
GeneOntologyMolecularFunction	ABC-type sterol transporter activity	ABCG4 ABCG1	4.32e-06	2	42	2	GO:0034041
GeneOntologyMolecularFunction	vitamin D response element binding	TCF3 RXRA	1.29e-05	3	42	2	GO:0070644
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX ATP2A1 DNAH6	2.69e-05	775	42	9	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX ATP2A1 DNAH6	5.00e-05	839	42	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX ATP2A1 DNAH6	5.04e-05	840	42	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX ATP2A1 DNAH6	5.04e-05	840	42	9	GO:0016818
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCG4 ABCG1 ABCG2 ATP2A1	8.01e-05	109	42	4	GO:0042626
GeneOntologyMolecularFunction	retinoic acid-responsive element binding	RXRA RXRG	9.01e-05	7	42	2	GO:0044323
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCG4 ABCG1 ABCG2	1.49e-04	49	42	3	GO:0140359
GeneOntologyMolecularFunction	protein dimerization activity	ABCG4 TCF3 RELA ABCG1 ABCG2 ACVR1 CLPX NEUROD6 ATP2A1 STAT3	1.54e-04	1205	42	10	GO:0046983
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCG4 ABCG1	1.54e-04	9	42	2	GO:0034040
GeneOntologyMolecularFunction	protein homodimerization activity	ABCG4 TCF3 RELA ABCG1 ABCG2 ACVR1 ATP2A1 STAT3	2.56e-04	815	42	8	GO:0042803
GeneOntologyMolecularFunction	nuclear receptor activity	RXRA RXRG STAT3	2.72e-04	60	42	3	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	RXRA RXRG STAT3	2.86e-04	61	42	3	GO:0098531
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCG4 ABCG1 ABCG2 ATP2A1	5.25e-04	178	42	4	GO:0015399
GeneOntologyMolecularFunction	nuclear steroid receptor activity	RXRA RXRG	1.26e-03	25	42	2	GO:0003707
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	NLRC5 TCF3 RFX6 RELA ZNF705EP NEUROD6 RXRA RXRG STAT3	2.86e-03	1459	42	9	GO:0000977
GeneOntologyBiologicalProcess	positive regulation of cholesterol efflux	ABCG4 ABCG1 RXRA	1.91e-05	27	40	3	GO:0010875
GeneOntologyBiologicalProcess	cellular response to high density lipoprotein particle stimulus	ABCG4 ABCG1	2.19e-05	4	40	2	GO:0071403
GeneOntologyBiologicalProcess	positive regulation of sterol transport	ABCG4 ABCG1 RXRA	6.35e-05	40	40	3	GO:0032373
GeneOntologyBiologicalProcess	positive regulation of cholesterol transport	ABCG4 ABCG1 RXRA	6.35e-05	40	40	3	GO:0032376
Domain	AAA+_ATPase	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX DNAH6	5.16e-10	144	39	8	IPR003593
Domain	AAA	PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX DNAH6	5.16e-10	144	39	8	SM00382
Domain	ABC_2_trans	ABCG4 ABCG1 ABCG2	8.39e-08	5	39	3	IPR013525
Domain	ABC2_membrane	ABCG4 ABCG1 ABCG2	8.39e-08	5	39	3	PF01061
Domain	ABC_TRANSPORTER_2	ABCG4 ABCG1 ABCG2 ABCF1	2.96e-06	48	39	4	PS50893
Domain	ABC_tran	ABCG4 ABCG1 ABCG2 ABCF1	2.96e-06	48	39	4	PF00005
Domain	ABC_TRANSPORTER_1	ABCG4 ABCG1 ABCG2 ABCF1	3.21e-06	49	39	4	PS00211
Domain	ABC_transporter-like	ABCG4 ABCG1 ABCG2 ABCF1	3.49e-06	50	39	4	IPR003439
Domain	ABCG1	ABCG4 ABCG1	4.25e-06	2	39	2	IPR020064
Domain	Nuc_recep-AF1	RXRA RXRG	4.25e-06	2	39	2	PF11825
Domain	Nuc_recep-AF1	RXRA RXRG	4.25e-06	2	39	2	IPR021780
Domain	-	NLRC5 PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX DNAH6	1.78e-05	746	39	9	3.40.50.300
Domain	P-loop_NTPase	NLRC5 PSMC4 ABCG4 RNF213 ABCG1 ABCG2 ABCF1 CLPX DNAH6	4.87e-05	848	39	9	IPR027417
Domain	ABC_transporter_CS	ABCG4 ABCG1 ABCF1	9.13e-05	42	39	3	IPR017871
Domain	Retinoid-X_rcpt/HNF4	RXRA RXRG	1.89e-04	10	39	2	IPR000003
Domain	LRRCT	LRIG2 LRIG3	2.03e-03	32	39	2	PF01463
Domain	zf-C4	RXRA RXRG	4.15e-03	46	39	2	PF00105
Domain	NUCLEAR_REC_DBD_1	RXRA RXRG	4.15e-03	46	39	2	PS00031
Domain	Znf_hrmn_rcpt	RXRA RXRG	4.15e-03	46	39	2	IPR001628
Domain	Nuclear_hrmn_rcpt	RXRA RXRG	4.15e-03	46	39	2	IPR001723
Domain	ZnF_C4	RXRA RXRG	4.15e-03	46	39	2	SM00399
Domain	NUCLEAR_REC_DBD_2	RXRA RXRG	4.15e-03	46	39	2	PS51030
Domain	-	RXRA RXRG	4.33e-03	47	39	2	1.10.565.10
Domain	HOLI	RXRA RXRG	4.51e-03	48	39	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	RXRA RXRG	4.51e-03	48	39	2	IPR000536
Domain	Hormone_recep	RXRA RXRG	4.51e-03	48	39	2	PF00104
Domain	p53-like_TF_DNA-bd	RELA STAT3	5.47e-03	53	39	2	IPR008967
Domain	ATPase_AAA_core	PSMC4 CLPX	5.68e-03	54	39	2	IPR003959
Domain	-	RXRA RXRG	6.31e-03	57	39	2	3.30.50.10
Domain	Znf_NHR/GATA	RXRA RXRG	6.52e-03	58	39	2	IPR013088
Domain	Ig_I-set	LRIG2 LRIG3 PTPRD	7.24e-03	190	39	3	IPR013098
Domain	I-set	LRIG2 LRIG3 PTPRD	7.24e-03	190	39	3	PF07679
Domain	LRR	LRIG2 NLRC5 LRIG3	8.44e-03	201	39	3	PS51450
Pathway	KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	RELA RXRA RXRG STAT3	1.33e-05	67	31	4	M10462
Pathway	WP_DELTANOTCH_SIGNALING_PATHWAY	TCF3 RELA MAML2 STAT3	2.97e-05	82	31	4	MM15922
Pathway	KEGG_MEDICUS_VARIANT_PAX8_PPARG_FUSION_TO_PPARG_MEDIATED_TRANSCRIPTION	RXRA RXRG	4.66e-05	5	31	2	M49023
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	PSMC4 ABCG4 ABCG1 ABCF1	6.23e-05	99	31	4	MM14986
Pathway	WP_VITAMIN_A1_AND_A5X_PATHWAYS	RXRA RXRG	6.98e-05	6	31	2	M48097
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	PSMC4 ABCG4 ABCG1 ABCF1	7.27e-05	103	31	4	M758
Pathway	REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS	PSMC4 RELA ABCG2 RXRA STAT3	8.67e-05	210	31	5	M41836
Pathway	KEGG_ABC_TRANSPORTERS	ABCG4 ABCG1 ABCG2	1.20e-04	44	31	3	M11911
Pathway	REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING	NLRC5 PSMC4 RELA STAT3	1.45e-04	123	31	4	MM15125
Pathway	PID_HES_HEY_PATHWAY	TCF3 MAML2 STAT3	1.56e-04	48	31	3	M288
Pathway	KEGG_MEDICUS_REFERENCE_THYROID_HORMONE_SIGNALING_PATHWAY	RXRA RXRG	1.67e-04	9	31	2	M47629
Pathway	REACTOME_INTERLEUKIN_1_FAMILY_SIGNALING	NLRC5 PSMC4 RELA STAT3	3.26e-04	152	31	4	M899
Pathway	WP_NONSMALL_CELL_LUNG_CANCER	RXRA RXRG STAT3	5.18e-04	72	31	3	M39738
Pathway	WP_NCRNAS_INVOLVED_IN_STAT3_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	RELA STAT3	6.24e-04	17	31	2	M39512
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCG4 ABCG1	6.24e-04	17	31	2	MM14552
Pathway	REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	ABCG4 ABCG1	7.01e-04	18	31	2	M524
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	RELA RXRA RXRG	8.13e-04	84	31	3	M3228
Pathway	WP_ACUTE_VIRAL_MYOCARDITIS	DMD ITGAL STAT3	8.42e-04	85	31	3	M39776
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	PSMC4 ABCG4 ABCG1 ABCG2 ABCF1 LCN1 ATP2A1	8.99e-04	736	31	7	M27287
Pubmed	Expression and functional characterization of ABCG1 splice variant ABCG1(666).	ABCG4 ABCG1 ABCG2	1.63e-08	5	42	3	16870176
Pubmed	The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea.	LRIG2 LRIG3	1.42e-06	2	42	2	15203213
Pubmed	Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.	ABCG4 ABCG1	1.42e-06	2	42	2	15240127
Pubmed	Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets.	RELA STAT3	1.42e-06	2	42	2	26891685
Pubmed	Human ABC transporters ABCG2 (BCRP) and ABCG4.	ABCG4 ABCG2	1.42e-06	2	42	2	18668433
Pubmed	Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2.	ABCG1 ABCG2	1.42e-06	2	42	2	23436212
Pubmed	Down-regulation of leucine-rich repeats and immunoglobulin-like domain proteins (LRIG1-3) in HP75 pituitary adenoma cell line.	LRIG2 LRIG3	1.42e-06	2	42	2	17393120
Pubmed	Protein tyrosine phosphatase receptor type D gene promotes radiosensitivity via STAT3 dephosphorylation in nasopharyngeal carcinoma.	PTPRD STAT3	1.42e-06	2	42	2	33824475
Pubmed	ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier.	ABCG4 ABCG2	1.42e-06	2	42	2	22391220
Pubmed	Roles of STAT3 in protein secretion pathways during the acute-phase response.	RELA STAT3	1.42e-06	2	42	2	23460517
Pubmed	Nuclear translocation of STAT3 and NF-κB are independent of each other but NF-κB supports expression and activation of STAT3.	RELA STAT3	1.42e-06	2	42	2	28089769
Pubmed	Association between functional genetic variants in retinoid X receptor-α/γ and the risk of gestational diabetes mellitus in a southern Chinese population.	RXRA RXRG	1.42e-06	2	42	2	34633445
Pubmed	Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.	LRIG2 LRIG3	1.42e-06	2	42	2	34839782
Pubmed	The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells.	NLRC5 STAT3	1.42e-06	2	42	2	33754073
Pubmed	Functional Cooperativity between ABCG4 and ABCG1 Isoforms.	ABCG4 ABCG1	1.42e-06	2	42	2	27228027
Pubmed	The retinoid X receptors and their ligands.	RXRA RXRG	1.42e-06	2	42	2	22020178
Pubmed	Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse.	RXRA RXRG	1.42e-06	2	42	2	10880050
Pubmed	[STAT3 and NF-κB is activated in papillary thyroid carcinoma tissues].	RELA STAT3	1.42e-06	2	42	2	27667468
Pubmed	NF-κB RelA Is Required for Hepatoprotection during Pneumonia and Sepsis.	RELA STAT3	1.42e-06	2	42	2	31160364
Pubmed	A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis.	RELA STAT3	1.42e-06	2	42	2	39137024
Pubmed	Schisandrin A reverses doxorubicin-resistant human breast cancer cell line by the inhibition of P65 and Stat3 phosphorylation.	RELA STAT3	1.42e-06	2	42	2	29181822
Pubmed	Isocyperol, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced inflammatory responses via suppression of the NF-κB and STAT3 pathways and ROS stress in LPS-stimulated RAW 264.7 cells.	RELA STAT3	1.42e-06	2	42	2	27240136
Pubmed	LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL.	ABCG4 ABCG1	1.42e-06	2	42	2	16556852
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.	ABCG4 ABCG1	1.42e-06	2	42	2	18039927
Pubmed	Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.	RELA STAT3	1.42e-06	2	42	2	22466650
Pubmed	Tetrandrine suppresses β‑glucan‑induced macrophage activation via inhibiting NF‑κB, ERK and STAT3 signaling pathways.	RELA STAT3	1.42e-06	2	42	2	27121946
Pubmed	Retinoid X receptor γ up-regulation is correlated with dedifferentiation of tumor cells and lymph node metastasis in papillary thyroid carcinoma.	RXRA RXRG	1.42e-06	2	42	2	21355951
Pubmed	Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice.	DMD ATP2A1	1.42e-06	2	42	2	33822956
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UBE4A FRY ABCF1 REV3L PTPRD CMYA5 NEUROD6 RXRG STAT3 PDE4DIP	2.29e-06	1285	42	10	35914814
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCG1 ABCG2 ABCF1	2.85e-06	23	42	3	10708515
Pubmed	Nicotine induces TIPE2 upregulation and Stat3 phosphorylation contributes to cholinergic anti-inflammatory effect.	RELA STAT3	4.27e-06	3	42	2	28766689
Pubmed	Tumor protein D52 (isoform 3) contributes to prostate cancer cell growth via targeting nuclear factor-κB transactivation in LNCaP cells.	RELA STAT3	4.27e-06	3	42	2	28466782
Pubmed	STAT3 signaling controls satellite cell expansion and skeletal muscle repair.	DMD STAT3	4.27e-06	3	42	2	25194572
Pubmed	HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis.	RELA STAT3	4.27e-06	3	42	2	24833467
Pubmed	ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane.	ABCG4 ABCG1	4.27e-06	3	42	2	25302608
Pubmed	Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.	RXRA RXRG	4.27e-06	3	42	2	11053444
Pubmed	Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.	DMD ATP2A1	4.27e-06	3	42	2	21285509
Pubmed	Retinoid X receptors: X-ploring their (patho)physiological functions.	RXRA RXRG	4.27e-06	3	42	2	15608692
Pubmed	Association of STAT3, CYP3A5, and ABCG2 Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients.	ABCG2 STAT3	4.27e-06	3	42	2	36974789
Pubmed	LRIGs: A Prognostically Significant Family with Emerging Therapeutic Competence against Cancers.	LRIG2 LRIG3	4.27e-06	3	42	2	27628597
Pubmed	Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis.	PTPRD STAT3	4.27e-06	3	42	2	24843164
Pubmed	ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production.	ABCG4 ABCG1	4.27e-06	3	42	2	27196068
Pubmed	Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance.	DMD STAT3	4.27e-06	3	42	2	26266089
Pubmed	Retinoid receptors trigger neuritogenesis in retinal degenerations.	RXRA RXRG	4.27e-06	3	42	2	21940995
Pubmed	Repurposing an old drug for new use: Niclosamide in psoriasis-like skin inflammation.	RELA STAT3	4.27e-06	3	42	2	31846070
Pubmed	Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression.	RELA STAT3	4.27e-06	3	42	2	29666362
Pubmed	The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers.	RXRA RXRG	4.27e-06	3	42	2	12824162
Pubmed	RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.	RXRA RXRG	4.27e-06	3	42	2	8799145
Pubmed	Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation.	RXRA RXRG	4.27e-06	3	42	2	8901052
Pubmed	STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration.	DMD STAT3	4.27e-06	3	42	2	27524611
Pubmed	Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.	RXRA RXRG	4.27e-06	3	42	2	7831303
Pubmed	NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells.	RELA STAT3	4.27e-06	3	42	2	22105366
Pubmed	Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB.	RELA RXRA	4.27e-06	3	42	2	10075655
Pubmed	Redistribution of LRIG proteins in psoriasis.	LRIG2 LRIG3	4.27e-06	3	42	2	18037903
Pubmed	Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.	RXRA RXRG	4.27e-06	3	42	2	1312497
Pubmed	SOCS3 promotor hypermethylation and STAT3-NF-κB interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells.	RELA STAT3	4.27e-06	3	42	2	23335796
Pubmed	Detection of retinoid X receptors using specific monoclonal and polyclonal antibodies.	RXRA RXRG	4.27e-06	3	42	2	7980510
Pubmed	Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate.	RXRA RXRG	4.27e-06	3	42	2	12514092
Pubmed	Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration.	ABCG2 DMD	4.27e-06	3	42	2	19265661
Pubmed	Chromosomal localization of the human retinoid X receptors.	RXRA RXRG	4.27e-06	3	42	2	8034312
Pubmed	LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.	LRIG2 LRIG3	4.27e-06	3	42	2	33469151
Pubmed	Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα.	RELA STAT3	4.27e-06	3	42	2	31484794
Pubmed	Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3.	RELA STAT3	4.27e-06	3	42	2	33279869
Pubmed	Genetic variants in vitamin D signaling pathways and risk of gestational diabetes mellitus.	RXRA RXRG	4.27e-06	3	42	2	27636996
Pubmed	The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer.	RXRA RXRG	4.27e-06	3	42	2	11839661
Pubmed	Retinoid X Receptor α Regulates DHA-Dependent Spinogenesis and Functional Synapse Formation In Vivo.	NEUROD6 RXRA	4.27e-06	3	42	2	32433958
Pubmed	Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2.	TCF3 STAT3	4.27e-06	3	42	2	24909826
Pubmed	ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.	ABCG4 ABCG1	4.27e-06	3	42	2	16902247
Pubmed	NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair.	RELA DMD	4.27e-06	3	42	2	25906153
Pubmed	Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB.	RELA STAT3	4.27e-06	3	42	2	12057007
Pubmed	ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2.	ABCG4 ABCG1	4.27e-06	3	42	2	17916878
Pubmed	STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells.	RELA STAT3	4.27e-06	3	42	2	21364020
Pubmed	Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.	TCF3 DMD ATP2A1	7.19e-06	31	42	3	16140986
Pubmed	Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice.	RXRA RXRG	8.53e-06	4	42	2	10079186
Pubmed	STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.	DMD ATP2A1	8.53e-06	4	42	2	18488020
Pubmed	Deregulated protein kinase A signaling and myospryn expression in muscular dystrophy.	DMD CMYA5	8.53e-06	4	42	2	18252718
Pubmed	Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein.	ABCG1 RXRA	8.53e-06	4	42	2	15319426
Pubmed	Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.	RELA RXRA	8.53e-06	4	42	2	16608838
Pubmed	Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.	RELA STAT3	8.53e-06	4	42	2	19345327
Pubmed	A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder.	CMYA5 RXRG	8.53e-06	4	42	2	26190982
Pubmed	Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.	RXRA RXRG	8.53e-06	4	42	2	1310259
Pubmed	Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins.	RXRA RXRG	8.53e-06	4	42	2	11641790
Pubmed	The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney.	RELA STAT3	8.53e-06	4	42	2	26678048
Pubmed	Pregnane X Receptor Expression in Human Pancreatic Adenocarcinoma: Associations With Clinicopathologic Parameters, Tumor Proliferative Capacity, Patients' Survival, and Retinoid X Receptor Expression.	RXRA RXRG	8.53e-06	4	42	2	26355550
Pubmed	Interleukin 10 protects primary melanocyte by activation of Stat-3 and PI3K/Akt/NF-κB signaling pathways.	RELA STAT3	8.53e-06	4	42	2	27186967
Pubmed	The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.	ABCG4 ABCG1	8.53e-06	4	42	2	31159502
Pubmed	Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.	RXRA RXRG	8.53e-06	4	42	2	19686701
Pubmed	ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins.	ABCG4 ABCG1	8.53e-06	4	42	2	15210959
Pubmed	Absence of thyroid hormone receptor beta-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis.	RXRA RXRG	8.53e-06	4	42	2	9804293
Pubmed	Role of ABCG1 and other ABCG family members in lipid metabolism.	ABCG1 ABCG2	8.53e-06	4	42	2	11590207
Pubmed	Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter.	RELA STAT3	8.53e-06	4	42	2	23370526
Pubmed	Role of transcription factor acetylation in diabetic kidney disease.	RELA STAT3	8.53e-06	4	42	2	24608443
Pubmed	Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism.	RELA STAT3	8.53e-06	4	42	2	14593105
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	ABCG4 ABCG1 STAT3	8.71e-06	33	42	3	26296893
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	ABCG4 RELA ABCG1 RXRA RXRG	1.26e-05	250	42	5	18660489
Pubmed	Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis.	ABCG1 RXRA	1.42e-05	5	42	2	23990020
Pubmed	Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene.	TCF3 RXRA	1.42e-05	5	42	2	17426122
Pubmed	Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta.	RELA RXRA	1.42e-05	5	42	2	14587029
Pubmed	Developmental expression of murine retinoid X receptor (RXR) genes.	RXRA RXRG	1.42e-05	5	42	2	8199055
Pubmed	Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.	DMD STAT3	1.42e-05	5	42	2	22606352
Cytoband	11q23.3	ABCG4 UBE4A	2.35e-03	78	42	2	11q23.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	LCN1 LCN1P1 RXRA	3.29e-03	325	42	3	chr9q34
GeneFamily	Blood group antigens\|CD molecules\|ATP binding cassette subfamily G	ABCG4 ABCG1 ABCG2	5.02e-08	5	32	3	811
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRIG2 LRIG3 PTPRD	2.84e-03	161	32	3	593
GeneFamily	Nuclear hormone receptors	RXRA RXRG	3.39e-03	49	32	2	71
GeneFamily	AAA ATPases	PSMC4 CLPX	3.95e-03	53	32	2	413
GeneFamily	Basic helix-loop-helix proteins	TCF3 NEUROD6	1.62e-02	110	32	2	420
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_12H_DN	NLRC5 RNF213 MAML2 UNC13A STAT3	1.41e-05	198	41	5	M4272
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	FRY DMD CMYA5 KCNJ3 PDE4DIP	1.06e-06	194	42	5	c3535f7cc0076653c72db582047cff053c322397
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRIG2 NLRC5 CMYA5 BIK	1.75e-05	165	42	4	34fd00be2b28716c871ad9fb356de84a299a0c01
ToppCell	COVID-19-Heart-CM_+_Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	1.97e-05	170	42	4	3f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCell	COVID-19-Heart-CM_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	2.26e-05	176	42	4	9df7a124ebafb0087da0cda133a394275d7bed81
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	2.52e-05	181	42	4	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	2.57e-05	182	42	4	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5 PDE4DIP	2.63e-05	183	42	4	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	FRY DMD CMYA5 PDE4DIP	2.68e-05	184	42	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	2.74e-05	185	42	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	FRY DMD CMYA5 PDE4DIP	2.74e-05	185	42	4	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5 PDE4DIP	2.74e-05	185	42	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5 PDE4DIP	2.74e-05	185	42	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCG1 MAML2 DNAH6 KCNJ3	2.80e-05	186	42	4	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5 PDE4DIP	2.86e-05	187	42	4	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	DMD CMYA5 KCNJ3 PDE4DIP	2.92e-05	188	42	4	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCG1 MAML2 DNAH6 KCNJ3	2.98e-05	189	42	4	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	ABCG2 DMD CMYA5 PDE4DIP	3.04e-05	190	42	4	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RFX6 KCNJ3 UNC13A BIK	3.04e-05	190	42	4	2375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RFX6 KCNJ3 UNC13A BIK	3.04e-05	190	42	4	b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	DMD CMYA5 KCNJ3 PDE4DIP	3.10e-05	191	42	4	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RFX6 KCNJ3 UNC13A BIK	3.23e-05	193	42	4	8603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	3.23e-05	193	42	4	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	DMD CMYA5 KCNJ3 PDE4DIP	3.30e-05	194	42	4	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	COVID-19_Moderate-CD8+_T_activated\|World / disease group, cell group and cell class	NLRC5 RNF213 SMAGP ITGAL	3.37e-05	195	42	4	070c5d3bdbd4ea54a579c01c37fb99bcf823982e
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RFX6 KCNJ3 UNC13A BIK	3.37e-05	195	42	4	5f33ece997f074598b4201ff74f592ee07c86a06
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	FRY DMD CMYA5 PDE4DIP	3.37e-05	195	42	4	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	severe-B_cell\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TCF3 FREM3 DOP1A BIK	3.37e-05	195	42	4	0fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell	LV-03._Atrial_Cardiomyocyte\|LV / Chamber and Cluster_Paper	DMD CMYA5 PDE4DIP	1.97e-04	120	42	3	3b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	DMD CMYA5 PDE4DIP	2.07e-04	122	42	3	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Follicular-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	RFX6 PTPRD KCNJ3	2.22e-04	125	42	3	519a474238e370fe2a8b51460c28b39c1b01c0c9
ToppCell	LV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	DMD CMYA5 PDE4DIP	2.49e-04	130	42	3	a3e12984fb61311e49cc76c59f74f4dffc48faa1
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	LRIG2 MAML2 FREM3	2.78e-04	135	42	3	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	PND07-28-samps-Lymphocyte-B_cell-B_cell_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NLRC5 BPIFC ATP2A1	2.91e-04	137	42	3	2544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCell	PND07-28-samps-Lymphocyte-B_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NLRC5 BPIFC ATP2A1	2.91e-04	137	42	3	874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCell	facs-Skin-Anagen-24m-Epithelial-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRC5 SMAGP ABCG1	3.03e-04	139	42	3	da8874d441b8e69c94bad771635f378ddafb49fe
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NLRC5 ABCG1 UNC13A	3.50e-04	146	42	3	bb7bf20245d93c8812920dd0debbf1ed00add378
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	LRIG2 MAML2 FREM3	3.72e-04	149	42	3	768877bade04ca0321593b8470b5011ad8270431
ToppCell	Transverse-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	NLRC5 CLPX BIK	3.86e-04	151	42	3	6870f3b5d2bfad849c3203658b5f28f0ae181295
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMAGP ABCG1 ITGAL	3.94e-04	152	42	3	82a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCell	LPS-IL1RA-Myeloid_granulocytic-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FREM3 ITGAL RXRA	4.09e-04	154	42	3	43735f7c58cac51855ded486ee8d8729a1b9909e
ToppCell	LPS-IL1RA-Myeloid_granulocytic\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FREM3 ITGAL RXRA	4.09e-04	154	42	3	d55fb73461885e1e02061a344ff89624ef4de487
ToppCell	facs-Skin-Anagen-24m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRC5 SMAGP ABCG1	4.09e-04	154	42	3	89a94a36dfd3d75e411038f04adaf0bbab17db45
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RNF213 MAML2 STAT3	4.25e-04	156	42	3	1545169694f686d28648a68b552c2ae606599d66
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMAGP ABCG1 RXRA	4.58e-04	160	42	3	0544bc465af208da448858d6e174ff56f2e08a46
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ABCG2 CMYA5 NEUROD6	4.75e-04	162	42	3	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ABCG2 CMYA5 NEUROD6	4.75e-04	162	42	3	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLRC5 ITGAL UNC13A	4.83e-04	163	42	3	9c91415a56b12b3b2d15d253bb59db8bedf49ea2
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RFX6 KCNJ3 UNC13A	4.92e-04	164	42	3	be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 DNAH6 UNC13A	5.01e-04	165	42	3	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM3 KCNJ3 UNC13A	5.09e-04	166	42	3	ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 KCNJ3 UNC13A	5.09e-04	166	42	3	d96c562e1483adb4cdd817b68133f03356d7279b
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMAGP ABCG1 ITGAL	5.27e-04	168	42	3	e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ABCG1 ITGAL RXRA	5.37e-04	169	42	3	305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RFX6 KCNJ3 UNC13A	5.37e-04	169	42	3	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RFX6 KCNJ3 UNC13A	5.37e-04	169	42	3	96a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	NLRC5 RNF213 STAT3	5.55e-04	171	42	3	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ABCG1 DUOXA1 BIK	5.65e-04	172	42	3	ba99688e9f46671deccf824b1e77c6db0742d7df
ToppCell	E12.5-Endothelial-proliferative_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ABCG1 DUOXA1 BIK	5.65e-04	172	42	3	2136170f6e1204734cec7dbf7b32e7d5179b92b5
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SMAGP TCF3 ABCG2	5.84e-04	174	42	3	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	facs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMAGP ACVR1 BIK	5.84e-04	174	42	3	42dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX6 DOP1A PDE4DIP	5.84e-04	174	42	3	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RNF213 ABCG1 ITGAL	5.84e-04	174	42	3	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	facs-Heart-RA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMAGP ACVR1 BIK	5.84e-04	174	42	3	f04edf2ca6788875c9918611e416fb739924382e
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMAGP ITGAL DNAH6	5.94e-04	175	42	3	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	COVID-19_Convalescent\|World / Disease Group and Platelet Clusters	ACVR1 DMD STAT3	5.94e-04	175	42	3	e9b1faa4c85537f30306619a2f3ada6c8ef0ac6c
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRIG2 MAML2 RXRA	6.04e-04	176	42	3	76fdf211bce101e83a27d822cb399487bd107027
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMD CMYA5 KCNJ3	6.04e-04	176	42	3	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD PDE4DIP	6.14e-04	177	42	3	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_NE_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RFX6 UNC13A BIK	6.24e-04	178	42	3	32cc4155267baf1b536a61310044e6502d09531f
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	DMD PDE4DIP BIK	6.24e-04	178	42	3	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD PDE4DIP	6.24e-04	178	42	3	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRIG3 PTPRD CMYA5	6.24e-04	178	42	3	0e1bedf991189d0ef9b40dac9281bdf4739333a1
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DMD FREM3 DNAH6	6.24e-04	178	42	3	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5	6.34e-04	179	42	3	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DMD NEUROD6 DNAH6	6.45e-04	180	42	3	b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCG4 LRIG3 PTPRD	6.45e-04	180	42	3	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RFX6 KCNJ3 UNC13A	6.45e-04	180	42	3	6b1606238417490e0d9930870a7827419d1c3737
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	NLRC5 ACVR1 DOP1A	6.45e-04	180	42	3	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCG4 LRIG3 PTPRD	6.45e-04	180	42	3	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DMD NEUROD6 DNAH6	6.45e-04	180	42	3	f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5	6.55e-04	181	42	3	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAML2 PTPRD KCNJ3	6.55e-04	181	42	3	6956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell	Control-Myeloid-DC1\|Control / Condition, Lineage and Cell class	SMAGP DMD BIK	6.55e-04	181	42	3	5a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD CMYA5	6.55e-04	181	42	3	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	RFX6 KCNJ3 UNC13A	6.66e-04	182	42	3	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PTPRD NEUROD6 DNAH6	6.66e-04	182	42	3	14a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DMD NEUROD6 DNAH6	6.66e-04	182	42	3	205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX6 ABCG1 UNC13A	6.66e-04	182	42	3	398ce074a04f6482470b488f1affae4af7d2ec58
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RFX6 ABCG1 UNC13A	6.76e-04	183	42	3	d26c7b79895de28961b8d68351f28d4bb531c75c
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	FRY PTPRD PDE4DIP	6.76e-04	183	42	3	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD PDE4DIP	6.76e-04	183	42	3	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD PDE4DIP	6.76e-04	183	42	3	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD PDE4DIP	6.76e-04	183	42	3	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRIG3 PTPRD CMYA5	6.87e-04	184	42	3	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	Control-Myeloid-DC1\|Myeloid / Condition, Lineage and Cell class	SMAGP DMD BIK	6.87e-04	184	42	3	b5c1f57f0356969cfb0e1dac764684fc5583bc04
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FRY PTPRD PDE4DIP	6.87e-04	184	42	3	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DMD NEUROD6 DNAH6	6.87e-04	184	42	3	ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY DMD DUOXA1	6.98e-04	185	42	3	7092436b4db90289516ed130ade596e3021cffaf
ToppCell	E12.5-Endothelial-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SMAGP ABCG1 BIK	6.98e-04	185	42	3	e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCell	E12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	SMAGP ABCG1 BIK	6.98e-04	185	42	3	0bccc424d0466f7f82baa00127c733640a2d50fb
Drug	13-HODE	RELA ABCG1 LCN1 LCN1P1 RXRA RXRG	1.54e-07	136	41	6	CID000001424
Drug	Bexarotene	RXRA RXRG	9.48e-06	3	41	2	DB00307
Drug	2-hydroxyphytanic acid	RXRA RXRG	9.48e-06	3	41	2	ctd:C002585
Drug	galiellalactone	RELA STAT3	9.48e-06	3	41	2	ctd:C416043
Drug	AC1O5SBP	RXRA RXRG	9.48e-06	3	41	2	CID006439746
Drug	T 0070907	RELA ABCG2 STAT3	1.07e-05	24	41	3	ctd:C458508
Drug	scoparone	RELA RXRA RXRG	1.21e-05	25	41	3	CID000008417
Drug	F-L-Leu	RELA ABCG1 RXRA RXRG	1.50e-05	83	41	4	CID000004308
Drug	AGN 190727	RXRA RXRG	1.89e-05	4	41	2	CID006439768
Drug	TCPOBOP	ABCG2 RXRA RXRG STAT3	2.56e-05	95	41	4	CID000005382
Drug	Guaifenesin [93-14-1]; Up 200; 20.2uM; HL60; HT_HG-U133A	ABCG2 RXRA UNC13A DOP1A PDE4DIP	2.62e-05	196	41	5	2569_UP
Drug	7-methoxycitronellal	RXRA RXRG	3.15e-05	5	41	2	CID000019223
Drug	7-methoxycitronellic acid	RXRA RXRG	3.15e-05	5	41	2	CID000171516
Drug	13,14-dihydroretinol	RXRA RXRG	3.15e-05	5	41	2	CID000446798
Drug	AC1L1JLU	RELA ABCG1 RXRA RXRG	3.65e-05	104	41	4	CID000005098
Drug	cerivastatin	ABCG2 ITGAL RXRA	3.71e-05	36	41	3	ctd:C086276
Drug	ferrous sulfate	RELA ABCF1 ATP2A1 STAT3	3.94e-05	106	41	4	ctd:C020748
Drug	E-guggulsterone	RELA RXRA RXRG STAT3	4.24e-05	108	41	4	CID006439929
Drug	Alitretinoin	RXRA RXRG	4.72e-05	6	41	2	DB00523
Drug	Adapalene	RXRA RXRG	4.72e-05	6	41	2	DB00210
Drug	2'-hydroxychalcone	RELA STAT3	4.72e-05	6	41	2	ctd:C013031
Drug	triphenyltin hydroxide	RXRA RXRG	4.72e-05	6	41	2	ctd:C007567
Drug	Etretinate	RXRA RXRG	4.72e-05	6	41	2	DB00926
Drug	Cholesterol	RELA ABCG1 ABCG2 RXRA BIK	5.50e-05	229	41	5	ctd:D002784
Drug	Clozapine	RELA ABCG1 ABCG2 UNC13A RXRG BIK	6.58e-05	390	41	6	ctd:D003024
Drug	Acitretin	RXRA RXRG	6.61e-05	7	41	2	DB00459
Drug	iomeprol	RELA STAT3	6.61e-05	7	41	2	ctd:C057937
Drug	AGN 191659	RXRA RXRG	6.61e-05	7	41	2	CID006366726
Drug	AGN 190121	RXRA RXRG	6.61e-05	7	41	2	CID006441236
Drug	flavone	RELA ABCG2 STAT3	6.82e-05	44	41	3	ctd:C043562
Drug	HX 600	RXRA RXRG	8.80e-05	8	41	2	ctd:C104181
Drug	TTNN	RXRA RXRG	8.80e-05	8	41	2	CID000135754
Drug	AC1O5JP6	RXRA RXRG	8.80e-05	8	41	2	CID006435379
Drug	pamidronate	ATP2A1 RXRG BIK	9.43e-05	49	41	3	CID000004673
Drug	Zlllal	PSMC4 RELA ABCG2 RXRA RXRG STAT3 BIK	1.01e-04	613	41	7	CID000107707
Drug	azelnidipine	RELA ITGAL STAT3	1.06e-04	51	41	3	CID000065948
Drug	6,2',4'-trimethoxyflavone	RELA ABCG2	1.13e-04	9	41	2	ctd:C546607
Drug	c219	ABCG2 RXRG	1.13e-04	9	41	2	CID004198643
Drug	9-HODE	RELA ABCG1 RXRA RXRG	1.23e-04	142	41	4	CID000001927
Drug	AC1NQAAM	RELA ABCG2 LCN1 LCN1P1	1.30e-04	144	41	4	CID005192834
Drug	Lindane	RELA ABCG1 ABCG2 ACVR1 RXRA RXRG	1.32e-04	443	41	6	ctd:D001556
Drug	azaspirane	RELA STAT3	1.41e-04	10	41	2	ctd:C099015
Drug	HX 630	RXRA RXRG	1.41e-04	10	41	2	ctd:C422175
Drug	LG 268	RXRA RXRG	1.41e-04	10	41	2	ctd:C423914
Drug	diazepinylbenzoic acid	RXRA RXRG	1.41e-04	10	41	2	ctd:C438269
Drug	AGN 191701	RXRA RXRG	1.72e-04	11	41	2	CID006438168
Drug	4,6-dihydroxy-2-mercaptopyrimidine	ACVR1 PTPRD	1.72e-04	11	41	2	CID001268265
Drug	mulberroside A	RELA ABCG2	1.72e-04	11	41	2	ctd:C420606
Drug	UVI 3003	RXRA RXRG	1.72e-04	11	41	2	ctd:C525131
Drug	Musk T	RXRA RXRG	1.72e-04	11	41	2	CID000061014
Drug	5,6,7-trimethoxyflavone	RELA STAT3	1.72e-04	11	41	2	ctd:C107364
Drug	Dichlorodiphenyl Dichloroethylene	RELA ABCG2 RXRA STAT3 BIK	2.01e-04	302	41	5	ctd:D003633
Drug	di-n-propylphthalate	RXRA RXRG	2.06e-04	12	41	2	ctd:C106479
Drug	morusin	RELA STAT3	2.06e-04	12	41	2	ctd:C057451
Drug	Tropicamide	RELA KCNJ3	2.06e-04	12	41	2	ctd:D014331
Drug	NSC46155	RXRA RXRG	2.06e-04	12	41	2	CID000457869
Drug	GW9662	RELA RXRA RXRG STAT3	2.09e-04	163	41	4	CID000644213
Drug	NSC618487	PSMC4 RELA ITGAL NEUROD6 ATP2A1 KCNJ3 STAT3 BIK	2.21e-04	933	41	8	CID000005279
Drug	verapamil	ABCG4 ABCG1 ABCG2 ABCF1 ATP2A1 KCNJ3	2.29e-04	490	41	6	CID000002520
Drug	Allopurinol	RELA ABCG2 STAT3	2.29e-04	66	41	3	ctd:D000493
Drug	ciglitazone	RELA RXRA RXRG STAT3	2.39e-04	169	41	4	CID000002750
Drug	Pravastatin	ABCG2 RXRA STAT3	2.40e-04	67	41	3	ctd:D017035
Drug	tazarotenic acid	RXRA RXRG	2.44e-04	13	41	2	CID000147525
Drug	GW2331	RXRA RXRG	2.44e-04	13	41	2	CID000657048
Drug	Cd2665	RXRA RXRG	2.44e-04	13	41	2	CID000216241
Drug	4'-methoxy licoflavanone	RELA STAT3	2.44e-04	13	41	2	ctd:C584368
Drug	DB02841	ABCG4 ABCG1 ABCG2	2.50e-04	68	41	3	CID005288987
Drug	dimethyl phthalate	BCCIP ABCG2 ATP2A1 RXRA KCNJ3 RXRG STAT3	2.57e-04	714	41	7	ctd:C024629
Drug	resolvin D2	RELA ITGAL	2.84e-04	14	41	2	ctd:C545423
Drug	AC1L1DMQ	RXRA RXRG	2.84e-04	14	41	2	CID000002418
Drug	3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid	RXRA STAT3	2.84e-04	14	41	2	ctd:C034534
Drug	alpinumisoflavone	RELA STAT3	2.84e-04	14	41	2	ctd:C000154
Drug	Sulfonamides	RXRA RXRG	2.84e-04	14	41	2	ctd:D013449
Drug	Fluorescein-5-isothiocyanate	RELA STAT3	2.84e-04	14	41	2	ctd:D016650
Drug	9-cis-acitretin	RXRA RXRG STAT3	2.85e-04	71	41	3	CID000041317
Drug	fluoroacetic acid	LCN1 CLPX LCN1P1	2.97e-04	72	41	3	CID000005236
Drug	Dextran Sulfate	NLRC5 RELA ITGAL STAT3	3.24e-04	183	41	4	ctd:D016264
Drug	resolvin D1	RELA ITGAL	3.27e-04	15	41	2	ctd:C518399
Drug	2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone	RELA STAT3	3.27e-04	15	41	2	ctd:C036837
Drug	13-hydroxyoctadecanoic acid	RELA ABCG1 RXRG	3.34e-04	75	41	3	CID005282911
Drug	Silymarin	RELA ABCG2 ATP2A1 STAT3	3.38e-04	185	41	4	ctd:D012838
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA	RELA ABCG1 KCNJ3 BIK	3.59e-04	188	41	4	986_DN
Drug	9-cis-retinal	RXRA RXRG	3.74e-04	16	41	2	ctd:C031390
Drug	Methylthiouracil	RELA STAT3	3.74e-04	16	41	2	ctd:D008779
Drug	17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid	RELA ITGAL	3.74e-04	16	41	2	ctd:C062894
Drug	3-isoreserpine	ABCG4 ABCG1 ABCG2 ABCF1	3.74e-04	190	41	4	CID000005052
Drug	Oils, Galangal	RELA ABCG1 CLPX STAT3	3.74e-04	190	41	4	CID000002889
Drug	AC1MHEDL	PTPRD RXRA RXRG	3.75e-04	78	41	3	CID003002890
Drug	AC1L1KPQ	ABCG1 RXRA RXRG	3.75e-04	78	41	3	CID000005602
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT_HG-U133A	ABCG4 ABCG1 DOP1A PDE4DIP	3.81e-04	191	41	4	4302_UP
Drug	Norcyclobenzaprine [303-50-4]; Up 200; 15.4uM; PC3; HT_HG-U133A	ABCG2 ITGAL UNC13A PDE4DIP	3.81e-04	191	41	4	4190_UP
Drug	Bile Acids and Salts	RELA RXRA STAT3	3.90e-04	79	41	3	ctd:D001647
Drug	AC1L1I71	ABCG2 LCN1 LCN1P1	3.90e-04	79	41	3	CID000004451
Drug	N6-methyladenosine [1867-73-8]; Up 200; 14.2uM; HL60; HT_HG-U133A	TCF3 RELA PDE4DIP BIK	4.12e-04	195	41	4	1271_UP
Drug	T0901317	ABCG1 RXRA RXRG	4.19e-04	81	41	3	CID000447912
Drug	dinitrogen	PSMC4 REV3L CLPX	4.19e-04	81	41	3	CID000000947
Drug	Liothyronine [6893-02-3]; Down 200; 6.2uM; PC3; HT_HG-U133A	TCF3 RELA ABCG1 PDE4DIP	4.20e-04	196	41	4	6602_DN
Drug	phthalic acid	RXRA RXRG	4.23e-04	17	41	2	ctd:C032279
Drug	Diatrizoate	RELA STAT3	4.23e-04	17	41	2	ctd:D003973
Drug	Glibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A	TCF3 RELA ABCG1 PDE4DIP	4.29e-04	197	41	4	7202_DN
Disease	odorant-binding protein 2b measurement	LCN1 LCN1P1	1.88e-05	5	41	2	EFO_0801859
Disease	hyperuricemia (implicated_via_orthology)	ABCG2 STAT3	3.94e-05	7	41	2	DOID:1920 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	NLRC5 RELA ABCG2 ACVR1 DMD PTPRD STAT3 DOP1A	9.84e-05	1074	41	8	C0006142
Disease	renal cell carcinoma (is_implicated_in)	RELA ABCG2 STAT3	1.22e-04	69	41	3	DOID:4450 (is_implicated_in)
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	TCF3 STAT3	1.23e-04	12	41	2	C0023485
Disease	electroencephalogram measurement	DMD PTPRD CMYA5	1.51e-04	74	41	3	EFO_0004357
Disease	Neonatal diabetes mellitus	RFX6 STAT3	5.54e-04	25	41	2	C0158981
Disease	cerebellum cortex volume change measurement, age at assessment	ABCG1 MAML2	5.99e-04	26	41	2	EFO_0008007, EFO_0021497
Disease	Liver Cirrhosis, Experimental	NLRC5 FRY RELA ABCG1 PTPRD ITGAL	6.57e-04	774	41	6	C0023893
Disease	renal cell carcinoma (is_marker_for)	RELA STAT3 BIK	7.53e-04	128	41	3	DOID:4450 (is_marker_for)
Disease	Mammary Carcinoma, Human	RELA ABCG2 ACVR1 PTPRD STAT3	7.73e-04	525	41	5	C4704874
Disease	Mammary Neoplasms, Human	RELA ABCG2 ACVR1 PTPRD STAT3	7.73e-04	525	41	5	C1257931
Disease	Mammary Neoplasms	RELA ABCG2 ACVR1 PTPRD STAT3	7.86e-04	527	41	5	C1458155
Disease	Breast Carcinoma	RELA ABCG2 ACVR1 PTPRD STAT3	8.62e-04	538	41	5	C0678222
Disease	personality trait	PTPRD RXRG	1.35e-03	39	41	2	EFO_0004365
Disease	lipoprotein-associated phospholipase A(2) measurement	RNF213 ABCG2	1.42e-03	40	41	2	EFO_0004746
Disease	valine measurement	ABCG2 NEUROD6	1.42e-03	40	41	2	EFO_0009792
Disease	migraine disorder	RNF213 REV3L DMD PTPRD	1.50e-03	357	41	4	MONDO_0005277
Disease	Secondary Biliary Cholangitis	RELA ABCG2	1.57e-03	42	41	2	C0238065
Disease	Biliary cirrhosis	RELA ABCG2	1.57e-03	42	41	2	C0023892
Disease	Biliary Cirrhosis, Primary, 1	RELA ABCG2	1.57e-03	42	41	2	C4551595
Disease	cervix uteri carcinoma in situ (is_marker_for)	RELA STAT3	1.57e-03	42	41	2	DOID:8991 (is_marker_for)
Disease	BMI-adjusted waist-hip ratio, sex interaction measurement	PTPRD RXRA	1.64e-03	43	41	2	EFO_0007788, EFO_0008343
Disease	Acute Promyelocytic Leukemia	ITGAL STAT3	1.88e-03	46	41	2	C0023487
Disease	Primary biliary cirrhosis	RELA ABCG2	1.96e-03	47	41	2	C0008312
Disease	Kidney Failure, Chronic	RELA ABCG1	2.04e-03	48	41	2	C0022661
Disease	Squamous cell carcinoma of the head and neck	ABCG2 STAT3	2.39e-03	52	41	2	C1168401
Disease	gout	ABCG1 ABCG2 PTPRD	2.56e-03	196	41	3	EFO_0004274
Disease	Colorectal Carcinoma	TCF3 ABCG1 ABCG2 DMD PTPRD	2.77e-03	702	41	5	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEKTIVLPPLTDQTM	UNC13A	1386	Q9UPW8
LFMEPTLLMLDEPTN	ABCF1	466	Q8NE71
FAALMPTVLTFPLEM	ABCG4	436	Q9H172
SIMEKLLLEPMFEVP	CLPX	566	O76031
MFAALMPTVLTFPLE	ABCG1	466	P45844
MPTVLTFPLEMGVFL	ABCG1	471	P45844
SDLLPMRMLPSIIFT	ABCG2	476	Q9UNQ0
LIMIALPSPSMEDEK	ACVR1	11	Q04771
MASIIPPDMILTLLE	DOP1A	1711	Q5JWR5
ISKLEMPSSLMLEVP	DMD	2456	P11532
MPSSLMLEVPALADF	DMD	2461	P11532
LLEPPTMEVLGMTDS	BIK	21	Q13323
FEAPEPMTMALSVLV	ATP2A1	891	O14983
LTDVLIPATMQEMPE	RFX6	326	Q8HWS3
MLPSFTKTPMDLTIR	LRIG3	601	Q6UXM1
SFDDVPMTPLRTVML	BCCIP	281	Q9P287
LPEMNLESVTPMTLT	LCN1P1	46	Q5VSP4
FPEMNLESVTPMTLT	LCN1	46	P31025
LDSLMLQMPSELPLS	NLRC5	961	Q86WI3
ISVPPMSDLELENMI	MAML2	316	Q8IZL2
DESLIPMFLTELMLT	DNAH6	506	Q9C0G6
FTLDIPASIMMLTQP	BPIFC	356	Q8NFQ6
ENMLEPSISLSEPLM	CMYA5	486	Q8N3K9
MTLSPSEETNPMELL	FRY	2541	Q5TBA9
PTFPMDTTLASIIMI	DUOXA1	16	Q1HG43
LIGDTPIDTFLMEML	RXRA	441	P19793
LPMEQLIVPADTTMT	PTPRD	966	P23468
LSEPLMAVLEFPEMA	FREM3	1861	P0C091
DVLPPEADSSIMMLT	PSMC4	141	P43686
MTSLLTTPSPREELM	SMAGP	1	Q0VAQ4
VDMVTLMSFSPAEIP	ITGAL	616	P20701
MEELPLMLLSEFSLV	RNF213	1761	Q63HN8
LMSPPSREEIMATLL	REV3L	1881	O60673
LSDLLDFSMMFPLPV	TCF3	16	P15923
MPYVETNEELIPLLM	PLPPR3	61	Q6T4P5
TIDLPMSPRTLDSLM	STAT3	721	P40763
TPIDTFLMEMLETPL	RXRG	446	P48443
PTSMTMENSLILEDP	ZNF705EP	101	A8MWA4
EFLDPIMSTLMCDPV	UBE4A	991	Q14139
PMLMEYPEAITRLVT	RELA	491	Q04206
QEEMLLMSSPLIAPA	KCNJ3	361	P48549
MPSFLKTPMDLTIRT	LRIG2	601	O94898
PTSMEVQPMTEELLK	PDE4DIP	206	Q5VU43
MLTLPFDESVVMPES	NEUROD6	1	Q96NK8