Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DDX12P DNA2 DDX11L8	2.26e-05	11	105	3	GO:0043139
GeneOntologyMolecularFunction	site-specific endodeoxyribonuclease activity, specific for altered base	APEX1 DNA2	2.74e-05	2	105	2	GO:0016890
GeneOntologyMolecularFunction	triplex DNA binding	DDX12P DDX11L8	1.63e-04	4	105	2	GO:0045142
Domain	HECW_N	HECW1 HECW2	2.84e-05	2	100	2	IPR032348
Domain	HECW_N	HECW1 HECW2	2.84e-05	2	100	2	PF16562
Domain	Junctophilin	JPH4 JPH3	1.69e-04	4	100	2	IPR017191
Domain	ANKRD13	ANKRD13B ANKRD13C	1.69e-04	4	100	2	IPR021832
Domain	GPCR_chapero_1	ANKRD13B ANKRD13C	1.69e-04	4	100	2	PF11904
Domain	HECT	HECW1 HECW2 HECTD1	3.97e-04	27	100	3	PF00632
Domain	HECTc	HECW1 HECW2 HECTD1	3.97e-04	27	100	3	SM00119
Domain	HECT_dom	HECW1 HECW2 HECTD1	3.97e-04	27	100	3	IPR000569
Domain	HECT	HECW1 HECW2 HECTD1	3.97e-04	27	100	3	PS50237
Domain	Glyco_hydro_47	MAN1A1 MAN1C1	5.86e-04	7	100	2	PF01532
Domain	-	MAN1A1 MAN1C1	5.86e-04	7	100	2	1.50.10.50
Domain	Leu-rich_rpt	CARMIL2 LRRC70 NXF2 SNRPA1 LRRC36 LRRC23 AMIGO2	6.36e-04	271	100	7	IPR001611
Domain	LRR	LRRC70 NXF2 SNRPA1 LRRC36 LRRC23 AMIGO2	7.43e-04	201	100	6	PS51450
Domain	Glyco_hydro_47	MAN1A1 MAN1C1	7.78e-04	8	100	2	IPR001382
Domain	-	CARMIL2 LRRC70 NXF2 SNRPA1 LRRC36 LRRC23 AMIGO2	1.70e-03	321	100	7	3.80.10.10
Domain	ABC_A	ABCA8 ABCA5	1.81e-03	12	100	2	IPR026082
Domain	L_dom-like	CARMIL2 LRRC70 NXF2 SNRPA1 LRRC36 LRRC23 AMIGO2	1.92e-03	328	100	7	IPR032675
Domain	WW	HECW1 HECW2 PLEKHA7	2.04e-03	47	100	3	PF00397
Domain	WW	HECW1 HECW2 PLEKHA7	2.16e-03	48	100	3	SM00456
Domain	ABC_tran	ABCA8 ABCA5 ABCC8	2.16e-03	48	100	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA8 ABCA5 ABCC8	2.16e-03	48	100	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA8 ABCA5 ABCC8	2.30e-03	49	100	3	PS00211
Domain	ABC_transporter-like	ABCA8 ABCA5 ABCC8	2.43e-03	50	100	3	IPR003439
Domain	MORN	JPH4 JPH3	2.48e-03	14	100	2	SM00698
Domain	WW_DOMAIN_2	HECW1 HECW2 PLEKHA7	2.57e-03	51	100	3	PS50020
Domain	WW_DOMAIN_1	HECW1 HECW2 PLEKHA7	2.57e-03	51	100	3	PS01159
Domain	WW_dom	HECW1 HECW2 PLEKHA7	2.72e-03	52	100	3	IPR001202
Domain	MORN	JPH4 JPH3	2.85e-03	15	100	2	IPR003409
Domain	MORN	JPH4 JPH3	2.85e-03	15	100	2	PF02493
Domain	ARM-like	STK36 DNAJC13 TSC2 MMS19 HECTD1 AGBL1	3.31e-03	270	100	6	IPR011989
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 PITRM1 MELK TIAM2 CAMKK2 CCDC88A SBF1 ACSBG1 ABCA5 HECW2 DNA2	6.88e-07	529	106	11	14621295
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 DNAJC13 PPFIA1 POLRMT BEND3 LIN9 CRK CCDC88A PLEC	5.64e-06	418	106	9	34709266
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LPCAT1 PPFIA1 CHAF1A POLRMT BEND3 NCKAP5L ABCA8 PHF2 KAT2B MMS19 TAF4 LONRF3 DNA2 AGBL1	7.68e-06	1116	106	14	31753913
Pubmed	Frontline Science: Cxxc5 expression alters cell cycle and myeloid differentiation of mouse hematopoietic stem and progenitor cells.	TET2 RAG2	9.20e-06	2	106	2	32083332
Pubmed	Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins.	JPH4 JPH3	9.20e-06	2	106	2	16809425
Pubmed	Congenital myasthenic syndrome associated with epidermolysis bullosa caused by homozygous mutations in PLEC1 and CHRNE.	CHRNE PLEC	9.20e-06	2	106	2	21175599
Pubmed	FYN-TRAF3IP2 induces NF-κB signaling-driven peripheral T cell lymphoma.	TET2 RAG2	9.20e-06	2	106	2	33928261
Pubmed	TEFM regulates both transcription elongation and RNA processing in mitochondria.	POLRMT TEFM	9.20e-06	2	106	2	31036713
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 CARMIL2 PPFIA1 TSC2 NCKAP5L MELK CCDC88A SBF1 PLEC PLEKHA7 HECTD1 DOP1A	1.28e-05	861	106	12	36931259
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	EEFSEC LPCAT1 DNAJC13 MYO1E IARS1 POLRMT FAM91A1 TEFM PLEC PLEKHA7	1.59e-05	601	106	10	33658012
Pubmed	Characterization of a cDNA encoding a novel human Golgi alpha 1, 2-mannosidase (IC) involved in N-glycan biosynthesis.	MAN1A1 MAN1C1	2.76e-05	3	106	2	10915796
Pubmed	TEFM (c17orf42) is necessary for transcription of human mtDNA.	POLRMT TEFM	2.76e-05	3	106	2	21278163
Pubmed	Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.	RAG2 GATA1	2.76e-05	3	106	2	28405615
Pubmed	Coexpression of junctophilin type 3 and type 4 in brain.	JPH4 JPH3	2.76e-05	3	106	2	14559359
Pubmed	Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex.	MAN1A1 MAN1C1	2.76e-05	3	106	2	2406237
Pubmed	Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.	RAG2 PYCARD	2.76e-05	3	106	2	27421701
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX12P DDX11L8	2.76e-05	3	106	2	17611414
Pubmed	Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.	JPH4 JPH3	2.76e-05	3	106	2	17904530
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX12P DDX11L8	2.76e-05	3	106	2	21854770
Pubmed	Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases.	MAN1A1 MAN1C1	5.50e-05	4	106	2	17727818
Pubmed	Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma.	TET2 RAG2	5.50e-05	4	106	2	35443168
Pubmed	Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver.	ABCA8 ABCA5	5.50e-05	4	106	2	16445568
Pubmed	Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells.	UTP14A GATA1	5.50e-05	4	106	2	7924983
Pubmed	The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.	MAPKAPK2 TSC2	5.50e-05	4	106	2	12582162
Pubmed	Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity.	JPH4 JPH3	5.50e-05	4	106	2	17347645
Pubmed	Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.	RAG2 TSC2	5.50e-05	4	106	2	27064374
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HECW1 HECW2 HECTD1	6.80e-05	26	106	3	26949039
Pubmed	NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.	HECW1 HECW2	9.15e-05	5	106	2	14684739
Pubmed	Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.	ABCA8 ABCA5	9.15e-05	5	106	2	12532264
Pubmed	Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.	JPH4 JPH3	9.15e-05	5	106	2	31461656
Pubmed	Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity.	RAG2 GATA1	9.15e-05	5	106	2	34429328
Pubmed	Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis.	RAG2 GATA1	9.15e-05	5	106	2	32130902
Pubmed	ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancer.	ABCA8 ABCC8	9.15e-05	5	106	2	28468577
Pubmed	Distinct roles for CARMIL isoforms in cell migration.	CARMIL2 MYO1E	9.15e-05	5	106	2	19846667
Pubmed	Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.	RAG2 GATA1	9.15e-05	5	106	2	18371378
Pubmed	Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.	RAG2 GATA1	9.15e-05	5	106	2	29467297
Pubmed	ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery.	RAG2 PYCARD	1.37e-04	6	106	2	36933213
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	DDX12P HECTD1 DDX11L8	1.40e-04	33	106	3	15755804
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	STK36 MYO1E MAPKAPK2 POLRMT TSC2 HES2 TIAM2 SBF1 PDIA5 ZFYVE26 PLEC HECTD1	1.41e-04	1105	106	12	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EEFSEC PPFIA1 CHAF1A UTP14A POLRMT APEX1 FAM91A1 DHX33 LIN9 TEFM PHF2 SBF1 TAF4 PLEKHA7	1.84e-04	1497	106	14	31527615
Pubmed	The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.	KAT2B TACC1	1.91e-04	7	106	2	14767476
Pubmed	p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin.	MAPKAPK2 TSC2	1.91e-04	7	106	2	23315073
Pubmed	Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.	RAG2 GATA1	1.91e-04	7	106	2	37708282
Pubmed	Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2.	GATA1 TNNI3	1.91e-04	7	106	2	27713415
Pubmed	Gene expression profiling predicts clinical outcome of prostate cancer.	CHAF1A NIPA2	1.91e-04	7	106	2	15067324
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	TET2 LIN9 PHF2 TAF4 PLEC ZNF654	1.92e-04	272	106	6	31010829
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	DNAJC13 PITRM1 MYO1E IARS1 TTC21A TSC2 NCKAP5L MELK TEFM CCDC88A RPRD1A PLEC PLEKHA7	1.94e-04	1321	106	13	27173435
Pubmed	Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation.	MAN1A1 MAN1C1	2.55e-04	8	106	2	17121831
Pubmed	TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity.	RAG2 GATA1	2.55e-04	8	106	2	37566453
Pubmed	The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.	DDX12P DDX11L8	2.55e-04	8	106	2	22678773
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	DNAJC13 APEX1 SBF1 HECW2 NXF2 PLEKHA7 DOP1A	3.11e-04	420	106	7	28065597
Pubmed	Systemically dispersed innate IL-13-expressing cells in type 2 immunity.	RAG2 GATA1	3.27e-04	9	106	2	20534524
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DNAJC13 SBF1 MMS19 PLEC HECTD1	3.96e-04	202	106	5	33005030
Pubmed	Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure.	RAG2 PYCARD	4.08e-04	10	106	2	29281837
Pubmed	NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling.	HECW1 HECW2	4.97e-04	11	106	2	25555806
Pubmed	Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response.	RAG2 GATA1	4.97e-04	11	106	2	18768889
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	LPCAT1 FLYWCH2 IARS1 PPFIA1 APEX1 TSC2 DNAH14 UNC5C ELMOD3 LONRF3	5.38e-04	925	106	10	28986522
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TET2 EEFSEC FLYWCH2 IARS1 GATA1 APEX1 BEND3 LIN9 PHF2 TAF4 SNRPA1	5.54e-04	1103	106	11	34189442
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	LPCAT1 PPFIA1 TMEM199 FAM91A1 CCDC88A ANKRD13C TACC1	5.85e-04	467	106	7	30194290
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	JPH4 JPH3	5.95e-04	12	106	2	19095005
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DNAJC13 MAPKAPK2 MAN1C1 TTC21A SMOC2 DNAH14 PHF2 ABCC8 RASGEF1C PDIA5 TAF4 HECTD1 DOP1A	6.06e-04	1489	106	13	28611215
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	TET2 APEX1 CCDC88A TAF4 PLEC	6.08e-04	222	106	5	35941108
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	DNAJC13 APEX1 FAM91A1 CRK CCDC88A TACC1	6.18e-04	339	106	6	37232246
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STK36 HECW1 UTP14A ABCA8 PHF2 HECTD1 DOP1A	8.04e-04	493	106	7	15368895
Pubmed	Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.	RAG2 PYCARD	8.18e-04	14	106	2	27716507
Pubmed	NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.	HECW1 HECW2	8.18e-04	14	106	2	27119228
Pubmed	TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.	APEX1 NXF2	8.18e-04	14	106	2	11073998
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	DNAJC13 JPH4 CAMKK2 FER1L4 RASGEF1C PLEC LONRF3	8.32e-04	496	106	7	31343991
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EEFSEC UTP14A POLRMT FAM91A1 CCDC88A SBF1 DNA2 DDX11L8	8.64e-04	650	106	8	38777146
Pubmed	Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.	KAT2B TAF4	9.41e-04	15	106	2	12601814
Pubmed	MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.	MMS19 DNA2	9.41e-04	15	106	2	22678361
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN1A1 MAN1C1	9.41e-04	15	106	2	8892864
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	PITRM1 SBF1 TAF4 JPH3	9.58e-04	142	106	4	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	PITRM1 SBF1 TAF4 JPH3	9.84e-04	143	106	4	20198315
Pubmed	FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3.	UTP14A DHX33 PHF2 SNRPA1 AGBL1	9.99e-04	248	106	5	27926873
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	HECW1 UTP14A HES2 PHF2 DNA2	1.04e-03	250	106	5	33536335
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	PPFIA1 BEND3 NCKAP5L CCDC88A PLEKHA7	1.05e-03	251	106	5	29778605
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FAM91A1 CRK CCDC88A PLEC SNRPA1	1.15e-03	256	106	5	33397691
Pubmed	Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.	RAG2 GATA1	1.21e-03	17	106	2	35709757
Pubmed	Histone-like TAFs within the PCAF histone acetylase complex.	KAT2B TAF4	1.21e-03	17	106	2	9674425
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN1A1 MAN1C1	1.21e-03	17	106	2	2355006
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TET2 DNAJC13 MYO1E CAMKK2 CBX7 TACC1 HECTD1	1.30e-03	536	106	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TET2 DNAJC13 MYO1E CAMKK2 CBX7 TACC1 HECTD1	1.33e-03	538	106	7	10512203
Pubmed	Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles.	ANKRD13B CCDC88A	1.36e-03	18	106	2	29229865
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	HECW1 HECW2	1.52e-03	19	106	2	21572392
Pubmed	Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors.	RAG2 GATA1	1.52e-03	19	106	2	16292344
Pubmed	A novel custom resequencing array for dilated cardiomyopathy.	SGCD TNNI3	1.52e-03	19	106	2	20474083
Pubmed	Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.	RAG2 PYCARD	1.52e-03	19	106	2	30937919
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	TET2 EEFSEC MYO1E IARS1 APEX1 PDIA5 PLEC SNRPA1	1.53e-03	711	106	8	33022573
Pubmed	Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.	KAT2B TAF4	1.69e-03	20	106	2	10373431
Pubmed	A single cell transcriptional atlas of early synovial joint development.	GDF5 EGFL6	1.69e-03	20	106	2	32580935
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN1A1 MAN1C1	1.69e-03	20	106	2	12560567
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	EEFSEC DNAJC13 MYO1E IARS1 PPFIA1 UTP14A SBF1 PLEC	1.71e-03	724	106	8	36232890
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	CARMIL2 MYO1E PPFIA1 TMEM199 ELMOD3 PLEKHA7 AMIGO2	1.83e-03	569	106	7	30639242
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	FLYWCH2 PPFIA1 CHAF1A NCKAP5L MELK CCDC88A TACC1 HECTD1	1.85e-03	733	106	8	34672954
Pubmed	EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.	MYO1E PLEC	1.86e-03	21	106	2	33029523
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	HECW1 HECW2	1.86e-03	21	106	2	37005481
Pubmed	Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	SGCD PLEC	1.86e-03	21	106	2	20301582
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC13 PPFIA1 UTP14A TMEM199 POLRMT NCKAP5L CAMKK2 CCDC88A SBF1 PDIA5 TACC1 DNA2	1.93e-03	1487	106	12	33957083
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN1A1 MAN1C1	2.04e-03	22	106	2	8673525
Cytoband	17q24	CACNG1 ABCA8	2.35e-04	10	106	2	17q24
GeneFamily	Mannosidases alpha class 1	MAN1A1 MAN1C1	6.04e-05	4	58	2	1193
GeneFamily	ATP binding cassette subfamily A	ABCA8 ABCA5	8.98e-04	14	58	2	805
Coexpression	OVSYANNIKOVA_PBMC_FLUARIX_AGE_55_64YO_RESPONDERS_VS_NONRESPONDERS_28DY_UP	GRPEL2 PHF2 KAT2B	5.16e-06	9	105	3	M40906
Coexpression	GSE17186_BLOOD_VS_CORD_BLOOD_CD21HIGH_TRANSITIONAL_BCELL_UP	EEFSEC LPCAT1 MAPKAPK2 MAN1C1 CCDC88A NIPA2 SNRPA1	1.64e-05	200	105	7	M7185
Disease	cortical thickness	ANKRD13B ANO2 NFILZ CHAF1A BEND3 SMOC2 CRK CCDC88A RASGEF1C TACC1 CFAP57 PLEC PLEKHA7 AGBL1	3.66e-05	1113	104	14	EFO_0004840
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX12P DDX11L8	3.68e-05	3	104	2	DOID:0060535 (implicated_via_orthology)
Disease	cortical surface area measurement	TET2 GDF5 ANO2 DNAJC13 NFILZ PPFIA1 CHAF1A BEND3 SMOC2 CCDC88A UNC5C RASGEF1C TACC1 PLEKHA7 AGBL1	7.43e-05	1345	104	15	EFO_0010736
Disease	cardiomyopathy (implicated_via_orthology)	JPH4 SGCD TNNI3 JPH3	1.18e-04	71	104	4	DOID:0050700 (implicated_via_orthology)
Disease	hepatitis A virus cellular receptor 1 measurement	SGCD ABCA8	1.22e-04	5	104	2	EFO_0010601
Disease	Symptomatic Infantile Spasms	UPB1 TSC2	1.83e-04	6	104	2	C0393699
Disease	Cryptogenic Infantile Spasms	UPB1 TSC2	1.83e-04	6	104	2	C0393698
Disease	Salaam Seizures	UPB1 TSC2	1.83e-04	6	104	2	C1527366
Disease	Nodding spasm	UPB1 TSC2	1.83e-04	6	104	2	C0546878
Disease	spasmus nutans	UPB1 TSC2	1.83e-04	6	104	2	C1527306
Disease	Jackknife Seizures	UPB1 TSC2	1.83e-04	6	104	2	C0553558
Disease	Hypsarrhythmia	UPB1 TSC2	1.83e-04	6	104	2	C0684276
Disease	T-cell immunoglobulin and mucin domain 1 measurement	SGCD ABCA8	2.55e-04	7	104	2	EFO_0010812
Disease	urate measurement, bone density	DDX12P SGCD MAN1C1 DHX33 CLVS1 ABCA8 DNAH14 TIAM2 JPH3	3.48e-04	619	104	9	EFO_0003923, EFO_0004531
Disease	Colorectal Neoplasms	TET2 ABCA8 ABCA5 ABCC8 PYCARD JPH3	4.56e-04	277	104	6	C0009404
Disease	factor VII activating protease measurement	SGCD MELK TAF4	9.77e-04	55	104	3	EFO_0009368
Disease	myelodysplastic syndrome (implicated_via_orthology)	TET2 GATA1	1.25e-03	15	104	2	DOID:0050908 (implicated_via_orthology)
Disease	West Syndrome	UPB1 TSC2	3.23e-03	24	104	2	C0037769
Disease	Colorectal Carcinoma	TET2 ACAP1 ABCA8 ABCA5 ABCC8 PYCARD RIC3 JPH3	3.43e-03	702	104	8	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
IEARKALPRKLGRKL	TACC1	331	O75410
KKLPAGIKRKLCFAL	ABCA5	1431	Q8WWZ7
KKFKLKLLSVPLREG	PYCARD	21	Q9ULZ3
ALLYRLDKKPLKPIR	CNTNAP3	191	Q9BZ76
RAPGTIKDRIKKLLA	EGFL6	271	Q8IUX8
KKSPRRLLKTLELYL	ELMOD3	321	Q96FG2
EKRDLRNFLKLLKPP	ADGRF1	61	Q5T601
PRTLRKKLGTLFAFK	CARMIL2	1091	Q6F5E8
KRPRLLKALKELGDF	ANKRD13C	211	Q8N6S4
FKIIGPKRLAKDLFL	DOP1A	91	Q5JWR5
EKKFLTKLPEIRGRR	ACAP1	516	Q15027
KVPGNLFRLIKRLDL	AMIGO2	61	Q86SJ2
AFRKFLKGLASRKPL	APEX1	191	P27695
FEIGVPKLKKLFRKL	ANO2	696	Q9NQ90
RLPFKRLNLVPKGKA	CHAF1A	36	Q13111
GLLLRAEELILKKPR	CHRNE	376	Q04844
PLFRLLAKVGLRDKK	AGBL1	76	Q96MI9
LLSLGKKRDYLLRPA	CACNG1	126	Q06432
LPFKKGDILRIRDKP	CRK	151	P46108
GKILTPAKKSFLRRL	RAG2	511	P55895
GELKALKLRFGLLPL	NFILZ	86	A0A5F9ZHS7
LAKKARGKPVRLRLS	MELK	321	Q14680
LGKKQLDPSRIKLIR	BEND3	601	Q5T5X7
KRLAGIPVLLEKLRK	ANKRD13B	111	Q86YJ7
KFAKSRPIIKRFLGK	HECW2	266	Q9P2P5
DSRSLRLKIKFPKLG	DGKK	1211	Q5KSL6
RLVRGLGLKPEKLEK	LPCAT1	336	Q8NF37
KDGLLGAELRILRKK	GDF5	231	P43026
GFRLRNLLKLPKAHK	LIN9	106	Q5TKA1
PLLLKRRKKARALEA	MAPKAPK2	381	P49137
FGLKKSKLPALNRRT	NCKAP5L	921	Q9HCH0
QLRSAPRAKKLEKLG	KAT2B	81	Q92831
AELRKSLKPLLEKRR	HES2	11	Q9Y543
VIRALAKPLDDKKRL	MMS19	996	Q96T76
KFAKSRPIIKRFLGK	HECW1	286	Q76N89
EPRLLKEKVRGLFEK	CFAP57	1066	Q96MR6
KFFRRKTARDLLPIK	FAM91A1	146	Q658Y4
AAPRKPRKFSKLVLL	FLYWCH2	31	Q96CP2
AKKLLAKLRFLAEEP	FER1L4	641	A9Z1Z3
LLPLALRRGKVKEKV	JPH4	346	Q96JJ6
LKRLPFLRNRPKDKD	CCDC88A	1466	Q3V6T2
GELAKLRDLPKLRAL	LRRC23	261	Q53EV4
LLLNKKFLGPARDLL	LRRC36	546	Q1X8D7
GSFILKKKGLLRLAR	NIPA2	26	Q8N8Q9
RKKFRPKDIRGLAAG	PPFIA1	1141	Q13136
LLLPKAFLSRGKRQE	RIC3	21	Q7Z5B4
EKVFRGLLLLEAKLK	GRPEL2	141	Q8TAA5
KRLDPGIFKGLLNLR	LRRC70	121	Q7Z2Q7
EAKKLLPAVLRALKG	SBF1	581	O95248
KGLRLELPLDRIVKF	PANX3	26	Q96QZ0
EMKKALRKLIGRLFP	OR7G1	296	Q8NGA0
LIRPKKRLIVSKRAG	GATA1	241	P15976
PKLKLRKLELRVSGG	ANP32C	61	O43423
LLLVLLFEGRKALPK	HECTD1	326	Q9ULT8
LRKLPSLKDGKFILS	GSTT4	51	A0A1W2PR19
RKKLGKRTLLPLRKA	DCST1	421	Q5T197
KRVLYGKELRKLDLP	UPB1	26	Q9UBR1
LLGRLAARKKIFQEP	DDX11L8	726	A8MPP1
KRGPKPKRLLLQRLY	CBX7	71	O95931
KGGLLGRLAARKKIF	DDX12P	741	Q92771
KAAQKRRKELGKLPL	DHX33	211	Q9H6R0
LARRAAKGFLKLGLK	ACSBG1	141	Q96GR2
LRKPREFLIALLEKL	DNAJC13	1996	O75165
LKKLIRRTKDTLGAP	DNAH14	1906	Q0VDD8
RIKAIRLGEKLLPAF	MAN1C1	281	Q9NR34
FRKKAVELGVKLLPA	MAN1A1	301	P33908
LSKKKLIRQAGFPRR	CAMKK2	196	Q96RR4
ADLKLDFKDVLLRPK	GMPR	6	P36959
LLKLAKFKIGFLRLG	DNA2	686	P51530
KTFLPLLRKSKGRLV	HSD17B2	201	P37059
LKKREPLRKRLAFAE	POLRMT	851	O00411
DFRRLLKKEEKPLLI	PDIA5	161	Q14554
KDPYLKGELLRRTKR	NXF2	451	Q9GZY0
EVKDALLRALGRKPL	OR10J4	296	P0C629
LTALAAIGPRKKRKV	TAF4	1006	O00268
KRDLSFLLDKKAVLP	PHF2	701	O75151
KLDGFPLLRRLKTLL	SNRPA1	56	P09661
ILRKLPRIKKHLLNG	PITRM1	761	Q5JRX3
TGRDLLKDRSLKPVK	PLEKHA7	671	Q6IQ23
LRKLLKPDIERERLK	TEFM	151	Q96QE5
KVFGLRSRKLKLFLN	IARS1	1216	P41252
ALKFIPKLGRSEKEL	STK36	31	Q9NRP7
RENLRLFAKIKGILP	ABCA8	576	O94911
LKRGAILEFDKPEKL	ABCC8	1551	Q09428
IKPFLKDKTRKRIFL	CLVS1	236	Q8IUQ0
KKILTPALKKRARAG	EEFSEC	541	P57772
LPRKLRAELEAALGK	TMEM199	26	Q8N511
RKSPRVLIKTLGKLD	TIAM2	156	Q8IVF5
RELRKAKPNRKLTFL	RPRD1A	46	Q96P16
KVGNSLFLDKRLKPR	SERPINA11	136	Q86U17
GEIKLDAAKIRLPRL	SGCD	231	Q92629
DIGKKEIKPFKRFLR	SMOC2	366	Q9H3U7
ARVRKFGPKLLQLLA	RASGEF1C	101	Q8N431
NRVRFELLPILKKGL	ZNF654	431	Q8IZM8
GVGLKPSAKKRRRFL	UTP14A	636	Q9BVJ6
PSAKKRRRFLIKAPE	UTP14A	641	Q9BVJ6
TGLCLLPLKEKKRER	PLEC	4251	Q15149
LPALKKEEGRKFLRP	TTC21A	601	Q8NDW8
KIFDLRGKFKRPTLR	TNNI3	131	P19429
ARSKIPRKFKLLGDD	TET2	1301	Q6N021
KAAAKRLKLAIFGPL	UNC5C	676	O95185
KKLLPVVFRRKLEFL	ZFYVE26	91	Q68DK2
LKEKFKILLGLGTPR	TSC2	11	P49815
LKLVLGRLPESLRYK	TSC2	706	P49815
NVKERALLPKFLLRG	VPS26C	166	O14972
DEDILLLPKRKRFRK	PP2D1	26	A8MPX8
GRRLPALLGLFKKKG	KIAA1522	6	Q9P206
GKRKNLIPLRASKIR	JPH3	346	Q8WXH2
LIAKFLPEELKERRK	LONRF3	526	Q496Y0
RFKGVKRDLLLTPKC	MYO1E	776	Q12965