Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK12 CDK13

9.75e-0510302GO:0008353
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat modifying activity

CDK12 CDK13

5.41e-0423302GO:0140994
GeneOntologyMolecularFunctioncyclin-dependent protein kinase activity

CDK12 CDK13

9.25e-0430302GO:0097472
GeneOntologyMolecularFunctioncyclin-dependent protein serine/threonine kinase activity

CDK12 CDK13

9.25e-0430302GO:0004693
GeneOntologyMolecularFunctioncyclin binding

CDK12 CDK13

1.26e-0335302GO:0030332
GeneOntologyMolecularFunctionprotein serine kinase activity

PRKDC CDK12 CDK13 HIPK1

2.03e-03363304GO:0106310
GeneOntologyCellularComponentcyclin/CDK positive transcription elongation factor complex

CDK12 CDK13

6.65e-059292GO:0008024
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

CDK12 CDK13

2.80e-0418292GO:0019908
GeneOntologyCellularComponentcarboxy-terminal domain protein kinase complex

CDK12 CDK13

5.03e-0424292GO:0032806
GeneOntologyCellularComponentserine/threonine protein kinase complex

PRKDC CDK12 CDK13

1.32e-03157293GO:1902554
GeneOntologyCellularComponentprotein kinase complex

PRKDC CDK12 CDK13

1.65e-03170293GO:1902911
GeneOntologyCellularComponenttranscription elongation factor complex

CDK12 CDK13

2.73e-0356292GO:0008023
GeneOntologyCellularComponentnuclear speck

SRSF6 CDK12 CDK13 HIPK1

2.81e-03431294GO:0016607
GeneOntologyCellularComponentadherens junction

TJP2 TNKS1BP1 DSG3

3.09e-03212293GO:0005912
GeneOntologyCellularComponentcyclin-dependent protein kinase holoenzyme complex

CDK12 CDK13

3.23e-0361292GO:0000307
GeneOntologyCellularComponentcornified envelope

HRNR DSG3

4.12e-0369292GO:0001533
GeneOntologyCellularComponenteuchromatin

SETD5 RBMX

4.47e-0372292GO:0000791
MousePhenoabsent inner ear

EYA1 FOXI3

3.58e-055272MP:0006285
MousePhenoabsent facial bone

HSPG2 EYA1 FOXI3

1.12e-0449273MP:0030385
MousePhenoabnormal pharyngeal pouch morphology

EYA1 FOXI3

1.28e-049272MP:0006031
MousePhenoabsent outer ear

EYA1 FOXI3

1.60e-0410272MP:0005579
MousePhenoabsent stapes

EYA1 FOXI3

1.95e-0411272MP:0004204
MousePhenoincreased embryonic tissue cell apoptosis

TJP2 EYA1 FOXI3 SETD5

1.99e-04153274MP:0013504
DomainKinase-like_dom

PRKDC CDK12 CDK13 HIPK1

9.37e-03542294IPR011009
PathwayREACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS

TJP2 DSG3

1.14e-0410232MM14956
PathwayREACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS

TJP2 DSG3

1.39e-0411232M9990
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TANC2 NHSL1 HSPG2 TNKS1BP1 MGAT4B PRKDC SETD5 CDK12 CDK13 SIPA1L3 C6orf132

9.95e-101105301135748872
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

TJP2 PRKDC SRSF6 CDK12 CDK13 RBMX SIPA1L3

2.03e-0836130726167880
Pubmed

The protein interaction landscape of the human CMGC kinase group.

TJP2 TNKS1BP1 SRSF6 CDK12 CDK13 HIPK1 RBMX SIPA1L3

9.70e-0869530823602568
Pubmed

Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.

CDK12 CDK13

7.19e-07230230319007
Pubmed

Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.

CDK12 CDK13

7.19e-07230225561469
Pubmed

Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

CDK12 CDK13

7.19e-07230224999027
Pubmed

Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.

CDK12 CDK13

7.19e-07230235857807
Pubmed

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

CDK12 CDK13

7.19e-07230220952539
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

TJP2 TNKS1BP1 PRKDC HRNR SRSF6 RBMX SIPA1L3

8.41e-0762630733644029
Pubmed

CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.

CDK12 CDK13

2.16e-06330237026485
Pubmed

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.

TNKS1BP1 PRKDC HRNR SRSF6 RBMX

2.55e-0625630532698014
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TJP2 TNKS1BP1 PRKDC SRSF6 CDK12 CDK13 RBMX

3.43e-0677430715302935
Pubmed

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

CDK12 CDK13

4.31e-06430222012619
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TANC2 TJP2 NHSL1 TNKS1BP1 DOCK11 SIPA1L3 C6orf132

6.89e-0686130736931259
Pubmed

Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.

CDK12 CDK13

7.18e-06530222547058
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

TJP2 NHSL1 TNKS1BP1 ABLIM3 SIPA1L3 C6orf132

7.63e-0656530625468996
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

TJP2 TNKS1BP1 PRKDC HRNR SRSF6 DSG3 RBMX SIPA1L3

8.19e-06125730836526897
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

TANC2 TNKS1BP1 PRKDC SRSF6 CDK12 RBMX

9.03e-0658230620467437
Pubmed

TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.

TNKS1BP1 PRKDC

1.08e-05630225749521
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

TANC2 TNKS1BP1 BSN ABLIM3 HIPK1

1.12e-0534730517114649
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

TJP2 SRSF6 CDK12 RBMX

1.37e-0517030416159877
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

PRKDC SRSF6 TMC5 BSN CDK12 RBMX

1.73e-0565330633742100
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

TJP2 TNKS1BP1 SRSF6

1.82e-055930328813667
Pubmed

Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept.

BSN PTPRG

2.01e-05830219567891
Pubmed

Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer.

HRNR RBMX

2.01e-05830235505093
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

TANC2 TJP2 NHSL1 TNKS1BP1 BSN ABLIM3 RBMX SIPA1L3

2.10e-05143130837142655
Pubmed

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer.

TJP2 PRKDC SRSF6 SETD5

2.85e-0520530428927264
Pubmed

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model.

PRKDC HLA-B

3.22e-051030237712758
Pubmed

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.

PRKDC HLA-B

3.22e-051030238426910
Pubmed

NLGN4X TCR transgenic T cells to treat gliomas.

PRKDC HLA-B

3.22e-051030237715782
Pubmed

HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice.

PRKDC HLA-B

3.22e-051030237877672
Pubmed

Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.

PRKDC HLA-B

3.22e-051030223869841
Pubmed

Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.

PRKDC HLA-B

3.22e-051030237219526
Pubmed

Antitumor activity of AZD0754, a dnTGFβRII-armored, STEAP2-targeted CAR-T cell therapy, in prostate cancer.

PRKDC HLA-B

3.22e-051030237966111
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

TANC2 NHSL1 BSN SIPA1L3

3.62e-0521830433378226
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

TANC2 TJP2 PRKDC DOCK11 SIPA1L3

3.71e-0544630524255178
Pubmed

Luzp4 defines a new mRNA export pathway in cancer cells.

TJP2 SRSF6 RBMX

4.55e-058030325662211
Pubmed

Cyclin-dependent kinases: a family portrait.

CDK12 CDK13

4.72e-051230219884882
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TJP2 TNKS1BP1 CDK12 CDK13 RBMX

6.56e-0550330516964243
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

TANC2 PRKDC SRSF6 CDK13

7.07e-0525930430404004
Pubmed

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.

EYA1 FOXI3

7.50e-051530216530750
Pubmed

Apical ectodermal ridge morphogenesis in limb development is controlled by Arid3b-mediated regulation of cell movements.

EN1 ARID3B

7.50e-051530221307092
Pubmed

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.

PRKDC HLA-B

7.50e-051530238413714
Pubmed

Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.

PRKDC HLA-B

8.57e-051630232723479
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TJP2 TNKS1BP1 PRKDC CDK12 ARID3B

9.90e-0554930538280479
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

HSPG2 TNKS1BP1 PRKDC HRNR

1.21e-0429830430737378
Pubmed

Functional proteomics mapping of a human signaling pathway.

HSPG2 HLA-B CDK12 CDK13 HIPK1

1.40e-0459130515231748
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

TJP2 TNKS1BP1 HRNR

1.45e-0411830330979931
Pubmed

The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.

EYA1 FOXI3

1.96e-042430226550799
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

HSPG2 BSN RBMX

1.97e-0413130328634551
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

TJP2 CDK13 RBMX

2.06e-0413330315144186
Pubmed

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.

TANC2 HRNR SRSF6 RBMX

2.32e-0435330427545878
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

TNKS1BP1 PRKDC SRSF6 RBMX SIPA1L3

2.33e-0466030532780723
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

TJP2 TNKS1BP1 PRKDC RBMX

2.50e-0436030433111431
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

TNKS1BP1 PRKDC HRNR SRSF6 CDK12 RBMX

2.80e-04108230638697112
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

TJP2 PRKDC SRSF6 RBMX SIPA1L3

3.35e-0471430528302793
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

TNKS1BP1 PRKDC DOCK11 CDK13

3.69e-0439930437536630
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

PRKDC HRNR SRSF6 CDK12 CDK13 RBMX

3.93e-04115330629845934
Pubmed

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

PRKDC RBMX

3.97e-043430211101529
Pubmed

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

BSN EN1

3.97e-043430225915474
Pubmed

FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors.

TJP2 EN1

4.20e-043530221074523
Pubmed

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

TNKS1BP1 PRKDC SRSF6 RBMX

4.40e-0441830435338135
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PRKDC CDK12 CDK13 RBMX ARID3B

4.43e-0475930535915203
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

HRNR BSN C6orf132 TECPR1

4.90e-0443030435044719
Pubmed

Network organization of the human autophagy system.

TJP2 PRKDC RBMX TECPR1

5.20e-0443730420562859
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

HRNR RBMX SIPA1L3

5.32e-0418430332908313
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

PRKDC SRSF6 RBMX ARID3B

5.38e-0444130431239290
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

TJP2 SRSF6 RBMX

5.67e-0418830329721183
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

HSPG2 HRNR

6.65e-044430231273033
Pubmed

A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.

BSN EN1

6.65e-044430219029045
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

TNKS1BP1 EYA1 CDK13 ARID3B

6.78e-0446930427634302
Pubmed

Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.

TNKS1BP1 RBMX

6.96e-044530223663784
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

HSPG2 TNKS1BP1 PRKDC HRNR RBMX

7.16e-0484430525963833
Pubmed

Deltex3 inhibits Epithelial Mesenchymal Transition in Papillary Thyroid Carcinoma via promoting ubiquitination of XRCC5 to regulate the AKT signal pathway.

PRKDC RBMX

7.27e-044630233403043
Pubmed

Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.

SRSF6 DOCK11 RBMX

7.29e-0420530327976729
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

NHSL1 TNKS1BP1 SIPA1L3

7.70e-0420930336779422
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TANC2 TNKS1BP1 SRSF6 PTPRG SETD5 ARID3B

8.05e-04132130627173435
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TANC2 ABLIM3 CDK13 SIPA1L3

8.16e-0449330415368895
Pubmed

Protein profile of exosomes from trabecular meshwork cells.

HSPG2 HRNR

8.25e-044930221362503
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

HSPG2 PRKDC HRNR CDK12 CDK13

8.55e-0487830537223481
InteractionTOP3B interactions

TANC2 NHSL1 HSPG2 TNKS1BP1 MGAT4B PRKDC SETD5 CDK12 CDK13 SIPA1L3 C6orf132

4.47e-0614703011int:TOP3B
InteractionCDH1 interactions

TJP2 NHSL1 TNKS1BP1 PRKDC PTPRG ABLIM3 SIPA1L3 C6orf132

1.19e-05768308int:CDH1
InteractionCLK1 interactions

TJP2 PRKDC SRSF6 CDK12 RBMX

1.65e-05219305int:CLK1
InteractionYWHAE interactions

TANC2 TJP2 SRSF6 DOCK11 CDK12 CDK13 SIPA1L3 C6orf132 ARID3B

5.97e-051256309int:YWHAE
InteractionVASP interactions

TJP2 NHSL1 TNKS1BP1 SIPA1L3 C6orf132

6.75e-05294305int:VASP
GeneFamilyCyclin dependent kinases

CDK12 CDK13

4.11e-0426212496
GeneFamilyPDZ domain containing

TJP2 SIPA1L3

1.33e-021522121220
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 NHSL1 PTPRG SIPA1L3

9.12e-061983041996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

EYA1 TMC5 FOXI3

1.41e-041513038216462e723fec2797387929dde095370947e10a
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TJP2 HSPG2 TECPR1

1.67e-0416030333050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 TMC5 PTPRG

1.73e-041623032259e9536147e9cdee772e3a30ba7d104573262c
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 TMC5 PTPRG

1.86e-0416630389e2b8453180983533faccb4275867861876d7ee
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOXI3 ABLIM3 DSG3

1.89e-0416730369caf4a53805f8c104d7dd8f88665fc992e23720
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 ABLIM3 APCDD1L

1.96e-04169303337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 ABLIM3 APCDD1L

1.96e-04169303605cc2638271803cf1d972ab3fa8f13f89666376
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSPG2 HLA-B DSG3

2.10e-041733033877cead288ce9509e6cccf57e55ec5e1bd7ce18
ToppCellThalamus-Neuronal-Excitatory|Thalamus / BrainAtlas - Mouse McCarroll V32

BSN ABLIM3 TECPR1

2.21e-04176303d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

TANC2 HSPG2 APCDD1L

2.21e-0417630352af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellControl-Epithelial-Goblet|Control / Disease state, Lineage and Cell class

EYA1 TMC5 C6orf132

2.36e-041803035293d23b8b8ea587239ffde561b70bad01632521
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 HLA-B TECPR1

2.48e-0418330352af3c943116073c8ddd207b664342960b88929b
ToppCellControl-Epithelial-Goblet|World / Disease state, Lineage and Cell class

EYA1 TMC5 C6orf132

2.56e-041853039a793e6016295a63820e9d7563f195494ac692e7
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TANC2 TMC5 PTPRG

2.60e-04186303acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TANC2 NHSL1 HSPG2

2.60e-04186303ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TANC2 NHSL1 HSPG2

2.60e-04186303ed924852cd7132c8f6703522037dc22bd2c83193
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TANC2 NHSL1 HSPG2

2.60e-041863031e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TANC2 HSPG2 TNKS1BP1

2.60e-04186303c116cc9f41971622264434ebe29d18e719b0ae19
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HSPG2 TMC5 C6orf132

2.68e-0418830343a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYA1 DOCK11 SIPA1L3

2.68e-0418830363a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellfacs-Heart-LV-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TJP2 HSPG2 ABLIM3

2.68e-04188303e5a8ca4613ab0bf1584b9e78959adf41d0bf379f
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 EYA1 PTPRG

2.68e-04188303de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCellfacs-Heart-LV-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TJP2 HSPG2 ABLIM3

2.68e-04188303ed11e26ff4ef3d6314b5f5734062519b9aa285c1
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

TANC2 TMC5 PTPRG

2.68e-04188303ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellfacs-Heart-LV-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TJP2 HSPG2 ABLIM3

2.68e-041883030fc3a6562e6895f6fe7a93397eae842a75c60c93
ToppCellCOVID-19-Epithelial_cells-Tuft-like|COVID-19 / group, cell type (main and fine annotations)

EYA1 TMC5 C6orf132

2.72e-041893032ffbe79fe3c3f22b1cb4269726b9eb5519be84a7
ToppCellCOVID-19-Heart-EC_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

HSPG2 PTPRG ABLIM3

2.72e-04189303fe49852ba15f948b384d6b4c258927c70b741357
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

2.77e-041903036ea9fa08bd97bedcb21d3654467e7f8dd74c8fd0
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TANC2 HSPG2 C6orf132

2.77e-041903033cf464664d6aa22b212e60b70885953887e92483
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TANC2 NHSL1 HSPG2

2.77e-041903033b9abc25b17e7295356ded57ff2ca519fa9f2686
ToppCell10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HSPG2 TNKS1BP1 BSN

2.81e-04191303dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

2.81e-04191303cd709bbcd320373468ea7f058ee5fda8a067b5d0
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

2.81e-0419130314851529025cfc2b665f71ebad04150ec543da7a
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

2.81e-04191303e14b22e882ac92acf8c8b6ee997ef8e799c7a8d5
ToppCellCOPD-Epithelial-Goblet|COPD / Disease state, Lineage and Cell class

EYA1 TMC5 C6orf132

2.85e-0419230393b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TANC2 TMC5 PTPRG

2.90e-04193303fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TANC2 TMC5 PTPRG

2.90e-04193303f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TMC5 ABLIM3 C6orf132

2.90e-04193303a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 C6orf132 APCDD1L

2.94e-0419430346070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TANC2 C6orf132 APCDD1L

2.94e-04194303abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCellBL-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TNKS1BP1 PTPRG DSG3

2.94e-041943032932f704656ca368565ec12f3452af3b18e8df12
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NHSL1 HSPG2 PTPRG

2.94e-04194303e55dc30e200c9f576804acb642175eb4fa9146b5
ToppCell(7)_Epithelial-A_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TANC2 NHSL1 TMC5

2.99e-04195303c9a6c65ee18d83bf34a4713d306a6e30db1325c2
ToppCell3'-Airway_Nasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

2.99e-041953037ffbdbe95b248699bf6300322d084d21a4a4b1b8
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 PTPRG SIPA1L3

3.03e-04196303ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

EYA1 TMC5 PTPRG

3.03e-041963036d02d494196e3f857d53eea46d9419690d43beca
ToppCell3'-Airway_Nasal-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

3.03e-04196303eadc3e60104214cb5f6cfb098a5c5ea0f83d15bd
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

EYA1 TMC5 PTPRG

3.03e-04196303af4cdc61830685a888a1209826c23bcf54a43084
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

EYA1 TMC5 C6orf132

3.03e-0419630387d9881cfec461a5d89b688a83749b618c519485
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

NHSL1 TMC5 PTPRG

3.08e-0419730306ed8f293d4ee89f14dc2f43d6cae93bbc02508a
ToppCellNS-control-d_0-4-Epithelial-Squamous|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABLIM3 DSG3 C6orf132

3.08e-04197303ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

NHSL1 TMC5 PTPRG

3.08e-04197303c115d0a45545ed24259ad88872231bf4d4d389d2
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TJP2 TMC5 C6orf132

3.08e-04197303adb4e27d73ae2e6a39d212c0ead3ac0ad62d9131
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

HSPG2 HLA-B ABLIM3

3.08e-04197303f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell10x5'v1-week_12-13-Endothelial|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NHSL1 HSPG2 ABLIM3

3.12e-04198303307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HSPG2 TMC5 PTPRG

3.12e-04198303aed0476248e9637897eefb1623ec4035f2dacd82
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HSPG2 TMC5 PTPRG

3.12e-04198303691a2f1779225e5519155460eeb6a2aac5f67a92
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

HSPG2 TMC5 PTPRG

3.12e-04198303e115eea04012e9e492e923ed080e1723c38d14fd
ToppCellBAL-Severe-Epithelial-Epithelial-AT1/AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HSPG2 TMC5 PTPRG

3.12e-0419830333d1e0b6f57663544bee0ffdde83a65da764d44c
ToppCellSevere_COVID-19-Epithelial-AT1/AT2|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

HSPG2 TMC5 PTPRG

3.12e-0419830343e33d28d9de5033bd00d39be953542a225236ed
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 TMC5 PTPRG

3.12e-04198303f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell10x5'v1-week_12-13-Endothelial-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NHSL1 HSPG2 ABLIM3

3.12e-04198303122215d9288533ad03562cf777e846504863df9a
ToppCellNS-critical-d_07-13|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TJP2 TMC5 C6orf132

3.12e-04198303a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCellNS-critical-d_07-13-Epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TJP2 TMC5 C6orf132

3.17e-04199303b88a81cd2a89f4d27100c96ae4324dcee68daf83
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TANC2 NHSL1 TMC5

3.17e-041993038587bd98de7767a575088afbea07a1feb4516b9b
ToppCelltumor_Lung-Epithelial_cells-tS2|tumor_Lung / Location, Cell class and cell subclass

MGAT4B TMC5 C6orf132

3.17e-0419930328ec59e01061287fb0892491790b316e2b93e232
ToppCellEndothelial_cells-Endothelial-A|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id

HSPG2 PTPRG HLA-B

3.17e-041993032a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCellcritical-Epithelial|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TJP2 TMC5 C6orf132

3.17e-04199303bbb44e2a52f102a6d891ead6c06d6c07221abd33
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NHSL1 TMC5 SIPA1L3

3.17e-041993035cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellNS-critical-d_16-33-Epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TJP2 TMC5 C6orf132

3.17e-041993033b68197ec01c5f2b315d9e9b6eb02d5f6b5b77a3
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

TMC5 HLA-B DOCK11

3.17e-04199303155b03b859157013e9142e9248551369127d9204
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

HSPG2 PTPRG ABLIM3

3.17e-041993036a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellnormal_Pleural_Fluid-Epithelial_cells|normal_Pleural_Fluid / Location, Cell class and cell subclass

HSPG2 TMC5 C6orf132

3.17e-04199303564ba7acd03be2d6e4d0850cb2c7237a788dc275
ToppCellNS-moderate-d_16-33-Epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TJP2 TMC5 C6orf132

3.17e-04199303aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

HSPG2 PTPRG HLA-B

3.22e-0420030346dac23d8f9d426fe52ad6dac9c15ce91e615762
ToppCellmoderate-Epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TJP2 TMC5 C6orf132

3.22e-04200303095783c9b75113ae350c2d5fb1195d71b41fa695
Diseasemaximum cigarettes per day measurement

TMC5 HLA-B

1.41e-0418292EFO_0009264
DiseaseCongenital small ears

EYA1 FOXI3

7.47e-0441292C0152423
Diseaseendometriosis

EYA1 BSN ARID3B

1.91e-03252293EFO_0001065

Protein segments in the cluster

PeptideGeneStartEntry
LGSYYRYTGSLTTPP

PTPRG

246

P23470
GRRPSYSSSLFGYSP

ARID3B

326

Q8IVW6
ASSPGYIDSPTYSRQ

ABLIM3

371

O94929
SSYERSGSYSGRSPS

CDK12

311

Q9NYV4
SGSYSGRSPSPYGRR

CDK12

316

Q9NYV4
YAAGRYTRGTPSTRV

APCDD1L

331

Q8NCL9
YERGGDVSPSPYSSS

CDK13

376

Q14004
DTGYTRTPSGLYLGT

HSPG2

1141

P98160
GYPPPRDSYSSSSRG

RBMX

356

P38159
GTSYPTTSPGTRYGR

DSG3

596

P32926
TGQRSSYYSPFPAST

FOXI3

376

A8MTJ6
GRTATLRYPRSPDGY

MGAT4B

486

Q9UQ53
GSSRGSTIYTGYPLS

HIPK1

1186

Q86Z02
IYGGSSRSRAPSAYS

BSN

3436

Q9UPA5
YGRSRTPPSAASSRY

NHSL1

1501

Q5SYE7
TGSYANRYGRDPPTS

EYA1

341

Q99502
PYRSGSGWSSSRGPY

HRNR

1026

Q86YZ3
VYCTRYSDRPSSGPR

EN1

276

Q05925
YFYTSVSRPGRGEPR

HLA-B

31

P01889
PAAGRSPYTTTRYGS

C6orf132

1146

Q5T0Z8
ISGTSSDRGYGSPRY

DOCK11

2056

Q5JSL3
GSSTAYYVPRPCQGS

KRTAP26-1

81

Q6PEX3
YRPKLYSSGSSTPTG

SIPA1L3

1376

O60292
PTQSPGYSYRTTALR

SETD5

1266

Q9C0A6
PSSAYRGGVRYSQTP

TANC2

1701

Q9HCD6
YSSRRTSGRDKYGPP

SRSF6

91

Q13247
PSRPYQDTRGSYGSD

TJP2

1146

Q9UDY2
PVTGYTSRGLPTDRY

TECPR1

831

Q7Z6L1
RYGPRTYGTTTAPRD

TNKS1BP1

196

Q9C0C2
SYSYSSQDPRPATGR

PRKDC

2051

P78527
DYPGTRSNPYSVASR

TMC5

46

Q6UXY8