Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessorganelle assembly

FSIP2 TOGARAM1 UBQLN2 MDN1 CNOT1 HYDIN VPS13B CHMP5 SYNE2

5.31e-051138339GO:0070925
GeneOntologyBiologicalProcesspositive regulation of pyroptotic inflammatory response

GBP5 GBP7

8.87e-059332GO:0140639
GeneOntologyBiologicalProcesscytolysis in another organism

GBP5 GBP7

8.87e-059332GO:0051715
GeneOntologyCellularComponentcytoplasmic vesicle membrane

STAB2 CTNS GBP5 GBP7 USO1 VPS13C VPS13B CHMP5 UBR4

1.39e-041307339GO:0030659
GeneOntologyCellularComponentvesicle membrane

STAB2 CTNS GBP5 GBP7 USO1 VPS13C VPS13B CHMP5 UBR4

1.55e-041325339GO:0012506
GeneOntologyCellularComponentlysosomal membrane

CTNS VPS13C VPS13B CHMP5 KXD1

7.35e-04462335GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

CTNS VPS13C VPS13B CHMP5 KXD1

7.35e-04462335GO:0098852
GeneOntologyCellularComponentvacuolar membrane

CTNS VPS13C VPS13B CHMP5 KXD1

1.11e-03507335GO:0005774
DomainVPS13_C

VPS13C VPS13B

1.81e-054332IPR031645
DomainVPS13_C

VPS13C VPS13B

1.81e-054332PF16909
DomainSHR-BD

VPS13C VPS13B

1.81e-054332PF06650
DomainSHR-BD

VPS13C VPS13B

1.81e-054332IPR009543
DomainATG_C

VPS13C VPS13B

3.02e-055332PF09333
DomainAutophagy-rel_C

VPS13C VPS13B

3.02e-055332IPR015412
DomainVPS13_N

VPS13C VPS13B

8.42e-058332IPR026854
DomainChorein_N

VPS13C VPS13B

8.42e-058332PF12624
DomainGBP_C

GBP5 GBP7

1.35e-0410332PF02841
DomainGuanylate-bd_C

GBP5 GBP7

1.65e-0411332IPR003191
DomainGBP

GBP5 GBP7

1.65e-0411332PF02263
DomainG_GB1_RHD3_dom

GBP5 GBP7

1.65e-0411332IPR030386
DomainGuanylate-bd_N

GBP5 GBP7

1.65e-0411332IPR015894
DomainG_GB1_RHD3

GBP5 GBP7

1.65e-0411332PS51715
DomainARM-type_fold

KPNA5 TOGARAM1 UBQLN2 USO1 UBR4

2.99e-04339335IPR016024
DomainARM

KPNA5 USO1

2.26e-0340332SM00185
DomainARM_REPEAT

KPNA5 USO1

2.26e-0340332PS50176
DomainArmadillo

KPNA5 USO1

3.11e-0347332IPR000225
DomainUBA-like

UBQLN2 N4BP2

5.70e-0364332IPR009060
DomainConA-like_dom

RANBP9 SLIT2 RYR1

6.70e-03219333IPR013320
Domain-

MDN1 GBP5 GBP7 N4BP2 HYDIN

9.41e-037463353.40.50.300
DomainSPRY

RANBP9 RYR1

1.03e-0287332SM00449
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

SLIT2 MDN1 HYDIN SYNE2 UBR4

5.59e-0717033523314748
Pubmed

Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer.

SLIT2 RASSF1

2.62e-06333222315090
Pubmed

Analysis of the human VPS13 gene family.

VPS13C VPS13B

5.23e-06433215498460
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

FSIP2 CNOT1 SYNE2 ZNF292

5.63e-0612333426912792
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

KPNA5 ACBD3 VPS13C VPS13B SYNE2 KXD1

7.14e-0650433634432599
Pubmed

Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.

UBQLN2 N4BP2

8.72e-06533211717310
Pubmed

In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.

GBP5 GBP7

2.44e-05833216689661
Pubmed

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

GBP5 GBP7

3.13e-05933224739961
Pubmed

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

GBP5 GBP7

4.78e-051133224715728
Pubmed

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

GBP5 GBP7

4.78e-051133218025219
Pubmed

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

GBP5 GBP7

5.73e-051233235906252
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

UBQLN2 MDN1 ACBD3 VPS13C VPS13B CHMP5 SYNE2 UBR4

6.10e-05149633832877691
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SYNE2 UBR4 ZNF292

7.81e-058733312465718
Pubmed

Defining the membrane proteome of NK cells.

MDN1 GBP5 USO1 ACBD3 CNOT1 ADCY3 UBR4

9.40e-05116833719946888
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

RANBP9 MDN1 USO1 UBR4

1.25e-0427233431010829
Pubmed

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.

SLIT2 VPS13C

1.32e-041833227984743
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ADCY3 VPS13B ZNF292

1.37e-041053339628581
Pubmed

A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.

GBP5 GBP7

1.48e-041933221551061
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

ACBD3 VPS13C VPS13B CHMP5 SYNE2

1.86e-0456833537774976
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

UBQLN2 ADCY3 SYNE2 UBR4

2.39e-0432233426514267
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

RANBP9 MDN1 CNOT1

2.51e-0412933323022380
Pubmed

Substrate specificities and identification of putative substrates of ATM kinase family members.

PPP2R3A RASSF1

2.58e-042533210608806
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RANBP9 MDN1 CNOT1 N4BP2 SYNE2 UBR4

2.59e-0496333628671696
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

MDN1 USO1 ACBD3 CNOT1 UBR4

3.17e-0463833533239621
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MDN1 CNOT1 RYR1 SYNE2 UBR4

3.17e-0463833531182584
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

SLIT2 USO1 ACBD3 VPS13C CHMP5 SYNE2

3.29e-04100733634597346
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

SLIT2 CTNS VPS13C ENPP3 RYR1 CHMP5

3.45e-04101633619056867
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

SLIT2 VPS13C

3.99e-043133225838543
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

MDN1 USO1 UBR4

4.13e-0415333326365490
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

VPS13C N4BP2 UBR4

4.13e-0415333310718198
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

MDN1 ACBD3 CNOT1 SYNE2

4.25e-0437533432788342
Pubmed

The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor.

SLIT2 ADCY3

4.53e-043333226071364
Pubmed

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

KPNA5 UBR4

5.39e-043633235379950
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

MDN1 CNOT1 VPS13C RYR1 UBR4

6.08e-0473633529676528
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

USO1 CNOT1 N4BP2 UBR4

6.39e-0441833434709266
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

RANBP9 MDN1 USO1 ACBD3 CNOT1 UBR4

6.61e-04114933635446349
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

RANBP9 KPNA5

6.66e-044033228805822
Pubmed

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.

UBQLN2 UBR4

7.00e-044133232723828
Pubmed

Mig-6 controls EGFR trafficking and suppresses gliomagenesis.

ACBD3 HYDIN

8.80e-044633220351267
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MDN1 CNOT1 HYDIN RYR1 UBR4

9.20e-0480733530575818
InteractionPEX14 interactions

RANBP9 PPP2R3A ACBD3 CNOT1 N4BP2 SYNE2

2.11e-06237336int:PEX14
InteractionERGIC2 interactions

MDN1 USO1 ACBD3 VPS13B SYNE2

4.07e-05239335int:ERGIC2
InteractionMTNR1B interactions

UBQLN2 ADCY3 SYNE2 UBR4

6.78e-05135334int:MTNR1B
InteractionGBP7 interactions

GBP7 SYNE2

7.24e-058332int:GBP7
InteractionSYNE3 interactions

KPNA5 TOGARAM1 CNOT1 VPS13C N4BP2 SYNE2

7.39e-05444336int:SYNE3
Cytoband1p22.2

GBP5 GBP7

1.87e-04283321p22.2
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

HYDIN RYR1

1.85e-02181212694
GeneFamilyAnkyrin repeat domain containing

NRARP ANKRD31

3.17e-02242212403
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

SLIT2 TOGARAM1 PPP2R3A MDN1 ACBD3 VPS13B SYNE2 ZNF292

8.42e-06856338M4500
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KPNA5 ENPP3 VPS13B SYNE2 ZNF292

2.97e-071933359337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

ANKRD31 FSIP2 GBP5 SYNE2

3.94e-06145334ee99b58462f955b96d036aa67e343db047d66f64
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 VPS13C SYNE2

8.86e-0617833401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GBP5 N4BP2 SYNE2 ZNF292

1.29e-051963344a880a5d2c7047c050c7d6dd62186f35dc5c01f7
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-Treg|ICU-SEP / Disease, condition lineage and cell class

ANKRD31 FSIP2 GBP5 SYNE2

1.32e-05197334c3ee2d522fbfe67069ddba2d1abfc4f5ca230c26
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

TOGARAM1 VPS13C CHMP5 SYNE2

1.37e-0519933461b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

VPS13C CHMP5 SYNE2 ZNF292

1.37e-05199334fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellVE|World / Condition, Cell_class and T cell subcluster

GBP5 VPS13C CHMP5 SYNE2

1.40e-052003348ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 SYNE2 SANBR

1.67e-04145333734d85ca7a2e5e040f433cadc5f9be1f25cf2e91
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 SYNE2 SANBR

1.67e-041453338ba09eb0fd27f25aa90a3ad75d67a9f79f3f4f43
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

GBP5 CHMP5 SYNE2

1.91e-04152333b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCellCOVID-19_Moderate-MAIT|World / disease group, cell group and cell class

GBP5 NR1D1 SYNE2

2.23e-04160333bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

UBQLN2 N4BP2 SYNE2

2.27e-04161333f470b662566131dfe69a2fd01186ac8491196396
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

SLIT2 NR1D1 VPS13C

2.35e-04163333f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellnormal-na-Lymphocytic_T-T4_reg-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

TOGARAM1 GBP5 SYNE2

2.35e-0416333343887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

SLIT2 ENPP3 CHMP5

2.35e-04163333be774c0ba38fa89a9c0076524cf05d593c6c6826
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

2.39e-041643331cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HYDIN SYNE2 ZNF292

2.52e-041673333b717d33aaf1ef0869cc4bca8432ba8008875cc5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD31 GBP5 SYNE2

2.52e-04167333abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

ANKRD31 ENPP3 VPS13B

2.57e-0416833345ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PPP2R3A VPS13B SANBR

2.61e-04169333d2def7229fe9d6b0c70cfed349ede491c8c137a0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GBP5 RASSF1 SYNE2

2.61e-04169333f06118754fa62c580b4bcbecff6f9e5fdc2106a0
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-MAIT|Multiple_Sclerosis / Disease, Lineage and Cell Type

GBP5 NR1D1 SYNE2

2.75e-0417233318bda0038cb37da6784e7bf7291272c108cfd9c5
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 SYNE2

2.99e-04177333ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 SYNE2

2.99e-04177333f471f7747d6e8db7546899019af9508f48a14f89
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 GBP7 SYNE2

2.99e-04177333cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCellIIF-Lymphocyte-T_NK-MAIT|IIF / Disease, Lineage and Cell Type

GBP5 NR1D1 SYNE2

3.04e-04178333be777ebef8f09a1a16fcee8fc69a65ab295b6e1d
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

PPP2R3A HYDIN SYNE2

3.04e-04178333544379f5a6145429762258d426b876bb36c112f5
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_4|343B / Donor, Lineage, Cell class and subclass (all cells)

GBP5 ADCY3 RYR1

3.09e-04179333c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCellAdult-Immune-natural_killer_cell-D175|Adult / Lineage, Cell type, age group and donor

GBP5 RASSF1 SYNE2

3.15e-04180333fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

GBP5 ENPP3 SYNE2

3.15e-04180333974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

GBP5 ENPP3 SYNE2

3.15e-04180333703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 NR1D1 SYNE2

3.25e-04182333f30e5a21b49f30b82e2b6f1fd2daefd805a40083
ToppCellCOVID-19_Severe-Lymphoid_T/NK-MAIT|COVID-19_Severe / Disease group, lineage and cell class

GBP5 NR1D1 SYNE2

3.25e-0418233319045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 NR1D1 SYNE2

3.25e-041823331444cdc4522a70a40d697ccadf54cf26d327ade0
ToppCellwk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GBP5 GBP7 NR1D1

3.25e-041823336bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 NR1D1 SYNE2

3.25e-04182333cccac9f85825f4e310b86e37ee6320769a670501
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

GBP5 NR1D1 SYNE2

3.25e-0418233349eced222e8f90c2b59bcc7d56b62c3e703fcce5
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

PPP2R3A HYDIN SYNE2

3.30e-041833336878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellControl-CD8+_T_activated|Control / Disease group and Cell class

KPNA5 CNOT1 SANBR

3.35e-04184333b86cc48b744b3206880ec1373fe6068e14bf9680
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KPNA5 GBP5 SYNE2

3.41e-0418533399fe59c15c3c0f7afa7e182255e4bacfba346132
ToppCellBAL-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KPNA5 GBP5 SYNE2

3.41e-04185333191d7e9b34bd1598cb4c18e0cb3d018bad83c757
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

3.46e-04186333f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

3.46e-04186333b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

3.52e-04187333c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 NR1D1 SYNE2

3.52e-04187333f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

3.57e-04188333af740fa78542438fdff627ea1f74f4eee43316be
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 RASSF1 SYNE2

3.57e-04188333f8e6247bedc0ba494c5bb551539cb8ba5a97f557
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-Tregs|Lung / Manually curated celltypes from each tissue

GBP5 SYNE2 ZNF292

3.57e-04188333604f340052807bd902915eca942a97ccc36b42e0
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRARP HYDIN HDX

3.57e-04188333ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 RASSF1 SYNE2

3.57e-041883338155bc5476fc333bedcc78c5ddcc8e4912536caa
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A ENPP3 SYNE2

3.63e-04189333a48df46274d51e84ffb40264646de7346104efb9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

3.74e-04191333d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 VPS13B SYNE2

3.80e-04192333e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

GBP5 SYNE2 ZNF292

3.86e-041933332ffe44edf2b02d11a7c10513692eb697a10f911e
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 RASSF1 SYNE2

3.92e-04194333ac03be73fdc32dacd4a450c0fb28617e043b8444
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 RASSF1 SYNE2

3.92e-041943337ab4418a8a12c488d74af3676bdac672628da80c
ToppCellBLOOD--(1)_T_cell-(1)_MAIT-like_CD8_T_cells|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

GBP5 RASSF1 SYNE2

3.92e-04194333830342a4df39c24c30fb4746ce762af697716148
ToppCellCOVID-19_Severe-CD8+_Tem|World / disease group, cell group and cell class

GBP5 RASSF1 SYNE2

3.92e-0419433360aa16e166894e3fcd82f7a54607c2c02e55b614
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

3.92e-04194333760761ce7d22edf9a8cec71e8ab0caa273fce3f7
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRARP UBQLN2 GBP5

3.92e-04194333e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_Tem|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

3.92e-04194333e72be6dc2711c1d4f16943c8615cf9dc2e961ff3
ToppCellBLOOD--(1)_EM_CTLs| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

GBP5 RASSF1 SYNE2

3.92e-0419433366583c6cff3814902d6babdea3a2ae962decde65
ToppCellCOVID-19-lung-NK_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

GBP5 RASSF1 SYNE2

3.92e-041943334c92f18e0a34fb50630d4b260eaf179202508b6d
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRARP UBQLN2 GBP5

3.92e-041943334b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

GBP5 NR1D1 SYNE2

3.97e-0419533359164d115a0928cc9b79c7661c7190ad695f9d80
ToppCellcontrol-Lymphocytic-CD8_T_cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GBP5 RASSF1 SYNE2

3.97e-0419533355b9052336cab3e769a126ecaeef267d8e7bcaa8
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 NR1D1 SYNE2

3.97e-04195333c7b54b210cc2c8ddaefebfba74381adb2ca698b8
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 NR1D1 SYNE2

3.97e-04195333e173a713d273b135db4f71bdcaada3b0e55d74f1
ToppCellHealthy-CD8+_Tem|World / disease group, cell group and cell class

GBP5 RASSF1 SYNE2

3.97e-041953333d6f46b31c0254e9577a560364694b42964df198
ToppCellControl-CD8+_Tem|Control / Disease condition and Cell class

GBP5 RASSF1 SYNE2

3.97e-041953337503b3e032f95b350a2782d28e4d412a8dc9ebcc
ToppCellCOVID-19_Severe-CD8+_Tem|COVID-19_Severe / Disease condition and Cell class

GBP5 RASSF1 SYNE2

3.97e-04195333ff7ae62393e1c858a10592db8e6d9f36b8bae396
ToppCellCOVID-19_Severe-Lymphoid_T/NK-gd_T|COVID-19_Severe / Disease group, lineage and cell class

GBP5 RASSF1 SYNE2

3.97e-041953339990440bda7fac5d00ef80444fab07459be625e1
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-MAIT-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 NR1D1 SYNE2

3.97e-04195333a8fd42ff6c2bd80d0e3f20fe3bbf7d113b399df1
ToppCelllymphoid-T_cell-unlabelled(multiplets)|World / Lineage, cell class and subclass

NR1D1 CNOT1 RASSF1

4.03e-0419633378b006922307c154622d71fcbc79ae5eed3f4b23
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

4.03e-041963330f3c7fd450aaa1f866b8558692534c0ea2a34e75
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 RASSF1 SYNE2

4.03e-041963334e1f8828413896ab8a4ec92a89d6789e8e37e05a
ToppCellCOVID-19_Severe-CD8+_Tem|COVID-19_Severe / disease group, cell group and cell class

GBP5 RASSF1 SYNE2

4.03e-041963331bc1ec3351319c5d2daa0808cf161a7327e1758e
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 RASSF1 SYNE2

4.03e-041963336beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

4.03e-04196333c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 RASSF1 SYNE2

4.03e-04196333bc4628d959d76c16981ac3b943f7c3fbbba49391
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

GBP5 RASSF1 SYNE2

4.03e-04196333418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCell(2)_NK/T-(220)_CD8+_Cytotoxic_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

GBP5 RASSF1 SYNE2

4.03e-04196333d123361c32bcd2329200f0316bc5b54bb494e92d
ToppCell10x5'-blood-Lymphocytic_T_CD8|blood / Manually curated celltypes from each tissue

GBP5 RASSF1 SYNE2

4.03e-041963332bf0f36af1d0934c03999dbbff3c51ae9432386d
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

4.03e-04196333581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCellmild-Lymphocytic-CD8_T_cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

GBP5 RASSF1 SYNE2

4.09e-041973338b0e4012e25641c3bcd3e9911031e43d9dbbff21
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 RASSF1 SYNE2

4.09e-041973332b3a56bb1d40bc1284a5931c4e7b373660de5402
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD8+_Tem|COVID-19_Severe / Disease group, lineage and cell class

GBP5 RASSF1 SYNE2

4.09e-04197333f0bac4d5c3160933ac3786cec8dadffb35d711ea
ToppCellT/NK_cells-NKT_cell|T/NK_cells / Lineage and Cell class

GBP5 RASSF1 SYNE2

4.09e-0419733310702e61b510bfc7f54047ab3d8c700451a662b2
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GBP5 RASSF1 SYNE2

4.09e-04197333f73ece3aca28c0db5db0f12e026d42c6c36b9efb
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A HYDIN SYNE2

4.09e-041973337e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ENPP3 SYNE2 ZNF292

4.09e-0419733357ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

4.09e-04197333bce0135a96910d2bace62a3408a1a6fdac0cf0df
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_Tem|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GBP5 RASSF1 SYNE2

4.09e-04197333e70e7d97823a762def3970d94a0e897981a6c922
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 RASSF1 SYNE2

4.09e-04197333a44501cac24c2f4a53b413e92bd060eed6514616
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HYDIN SYNE2 SANBR

4.09e-0419733374a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellHealthy-CD8+_Tem|Healthy / disease group, cell group and cell class

GBP5 RASSF1 SYNE2

4.09e-041973338d60fdd5ce80c3496637fd3257d25258df6d7f75
ToppCell10x5'-blood-Lymphocytic_T_CD8-Tem/emra_CD8|blood / Manually curated celltypes from each tissue

GBP5 RASSF1 SYNE2

4.09e-0419733313e6611cde9364f0c1bf681b0b26c4d2725e5f4a
ToppCell(2)_NK/T-(22)_CD8+_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

GBP5 RASSF1 SYNE2

4.09e-0419733320dad8e4ed36a0185e231ddcb327725d2b2005e0
ToppCellT_cells-CTLs|World / Immune cells in Kidney/Urine in Lupus Nephritis

GBP5 RASSF1 SYNE2

4.09e-041973332de34e20915a247bee75aa40495e23c20bb23e18
DiseaseCohen syndrome (implicated_via_orthology)

VPS13C VPS13B

3.42e-063322DOID:0111590 (implicated_via_orthology)
Diseaseinsular cortex volume measurement

SLIT2 VPS13C

2.84e-0423322EFO_0010309
Diseaseatrial fibrillation

PPP2R3A SYNE2 ZNF292 SANBR

6.69e-04371324EFO_0000275
Diseasewaist circumference

PPP2R3A ADCY3 N4BP2 SYNE2

1.15e-03429324EFO_0004342
DiseaseIGF-1 measurement

PPP2R3A STAB2 VPS13C SYNE2

1.84e-03488324EFO_0004627
Diseasesusceptibility to vaginal yeast infection measurement

RANBP9 ANKRD31

2.27e-0365322EFO_0008412
Diseasedentures

ADCY3 HDX

2.63e-0370322EFO_0010078
Diseasedental caries, dentures

ADCY3 HDX

2.63e-0370322EFO_0003819, EFO_0010078

Protein segments in the cluster

PeptideGeneStartEntry
MIFSNNADQQLTATQ

KPNA5

91

O15131
NMSRSQQVNNFTSND

RANBP9

546

Q96S59
YNAQINSNLFMSLNK

RASSF1

146

Q9NS23
NLAQQSFNMEQANYT

CHMP5

81

Q9NZZ3
DLTNNNSSAQNFRMQ

ANKRD31

421

Q8N7Z5
ANMFAAAQQLSQNIS

MDN1

5471

Q9NU22
FASSNQLRLSQNQNN

HDX

401

Q7Z353
QSLLQNMTNCEFNVN

NRARP

31

Q7Z6K4
MNTLFVNNVVNEFNN

FSIP2

4006

Q5CZC0
LNFNNLSSARLQQMS

KXD1

46

Q9BQD3
QQMQEQAAQLSTTFQ

GBP5

546

Q96PP8
QLDSNFQMQSENFCS

GBP7

256

Q8N8V2
IMAALNSQTAVQFQQ

ACBD3

246

Q9H3P7
NSLDTNLTSMFLQNF

PPP2R3A

191

Q06190
QSAMNLANNQLSSQC

NR1D1

221

P20393
SIMNNSLAQLTFNQS

HYDIN

4441

Q4G0P3
NNMYDVNLNKNFSLS

ENPP3

226

O14638
TLTNINNQSFNNFML

ADCY3

1026

O60266
FSLLQMFLQSYNNDQ

CTNS

311

O60931
QNFVVQNEINNMSFL

RYR1

3456

P21817
LQNLLKNNNSNQNFF

USO1

236

O60763
KNFFQQTTTSFQNMA

SYNE2

3596

Q8WXH0
SENNNFLNNNNQMVL

SANBR

6

Q6NSI8
FIFNNLSQSNMTQKV

CNOT1

1101

A5YKK6
NNLMTFSVQNQAAFQ

ZNF292

1026

O60281
MANQLIQFNTTDNGQ

STAB2

611

Q8WWQ8
FLMSLLNFLNNFQTA

VPS13C

1196

Q709C8
NNRISTLSNQSFSNM

SLIT2

786

O94813
KNSSNFMNTTNFQSL

VPS13B

671

Q7Z7G8
STNFSELQSQMQQQL

UBQLN2

161

Q9UHD9
FAQMGQNLLNQAASQ

TOGARAM1

1686

Q9Y4F4
NFLMDAIQTNFQQAS

UBR4

1816

Q5T4S7
FSTQNMNLNGENLEN

N4BP2

191

Q86UW6