Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	perineuronal net	ACAN NCAN BCAN	7.90e-06	10	86	3	GO:0072534
GeneOntologyCellularComponent	perisynaptic extracellular matrix	ACAN NCAN BCAN	1.08e-05	11	86	3	GO:0098966
GeneOntologyCellularComponent	synapse-associated extracellular matrix	ACAN NCAN BCAN	1.87e-05	13	86	3	GO:0099535
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4X NLGN4Y	9.98e-05	4	86	2	GO:0098983
GeneOntologyCellularComponent	GABA-ergic synapse	NLGN4X NLGN4Y ACAN NCAN BCAN	5.84e-04	164	86	5	GO:0098982
Domain	NLGN4	NLGN4X NLGN4Y	2.10e-05	2	86	2	IPR030025
Domain	HR1_rho-bd	PPFIA1 FNBP1L TRIP10	2.01e-04	25	86	3	IPR011072
Domain	Nlgn	NLGN4X NLGN4Y	2.08e-04	5	86	2	IPR000460
Domain	CUT	ONECUT2 CUX2	4.34e-04	7	86	2	PS51042
Domain	CUT	ONECUT2 CUX2	4.34e-04	7	86	2	PF02376
Domain	CUT_dom	ONECUT2 CUX2	4.34e-04	7	86	2	IPR003350
Domain	CUT	ONECUT2 CUX2	4.34e-04	7	86	2	SM01109
Domain	SH3_1	ARHGAP9 ARHGEF4 FNBP1L ARHGEF26 TRIP10	9.64e-04	164	86	5	PF00018
Domain	LINK	NCAN BCAN	1.58e-03	13	86	2	SM00445
Domain	Link_dom	NCAN BCAN	1.58e-03	13	86	2	IPR000538
Domain	Xlink	NCAN BCAN	1.58e-03	13	86	2	PF00193
Domain	Carboxylesterase_B_CS	NLGN4X NLGN4Y	1.58e-03	13	86	2	IPR019819
Domain	LINK_1	NCAN BCAN	1.58e-03	13	86	2	PS01241
Domain	LINK_2	NCAN BCAN	1.58e-03	13	86	2	PS50963
Domain	CARBOXYLESTERASE_B_2	NLGN4X NLGN4Y	1.84e-03	14	86	2	PS00941
Domain	COesterase	NLGN4X NLGN4Y	1.84e-03	14	86	2	PF00135
Domain	CarbesteraseB	NLGN4X NLGN4Y	1.84e-03	14	86	2	IPR002018
Domain	DH_1	NET1 ARHGEF4 ARHGEF26	3.07e-03	63	86	3	PS00741
Domain	SH3	ARHGAP9 ARHGEF4 FNBP1L ARHGEF26 TRIP10	3.22e-03	216	86	5	SM00326
Domain	SH3	ARHGAP9 ARHGEF4 FNBP1L ARHGEF26 TRIP10	3.22e-03	216	86	5	PS50002
Domain	SH3_domain	ARHGAP9 ARHGEF4 FNBP1L ARHGEF26 TRIP10	3.48e-03	220	86	5	IPR001452
Domain	RhoGEF	NET1 ARHGEF4 ARHGEF26	3.81e-03	68	86	3	SM00325
Domain	RhoGEF	NET1 ARHGEF4 ARHGEF26	4.13e-03	70	86	3	PF00621
Domain	DH_2	NET1 ARHGEF4 ARHGEF26	4.13e-03	70	86	3	PS50010
Domain	DH-domain	NET1 ARHGEF4 ARHGEF26	4.30e-03	71	86	3	IPR000219
Domain	-	NET1 ARHGEF4 ARHGEF26	4.30e-03	71	86	3	1.20.900.10
Domain	FCH	FNBP1L TRIP10	4.56e-03	22	86	2	PF00611
Domain	FCH	FNBP1L TRIP10	4.56e-03	22	86	2	SM00055
Domain	FCH_dom	FNBP1L TRIP10	4.98e-03	23	86	2	IPR001060
Domain	F_BAR	FNBP1L TRIP10	5.87e-03	25	86	2	IPR031160
Domain	F_BAR	FNBP1L TRIP10	5.87e-03	25	86	2	PS51741
Domain	fn3	FNDC1 SDK2 SPEG DSCAML1	6.67e-03	162	86	4	PF00041
Domain	-	ONECUT2 CUX2	6.83e-03	27	86	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	ONECUT2 CUX2	7.85e-03	29	86	2	IPR010982
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NLGN4X NLGN4Y PPFIA1 EPB41L2	1.52e-04	67	57	4	MM15327
Pathway	REACTOME_ECM_PROTEOGLYCANS	COL5A1 ACAN NCAN BCAN	2.48e-04	76	57	4	M27219
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NLGN4X NLGN4Y EPB41L2	2.86e-04	32	57	3	MM15326
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	ADRA1D NET1 ARHGEF4 ARHGEF26	3.02e-04	80	57	4	M800
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NLGN4X NLGN4Y PPFIA1 EPB41L2	4.17e-04	87	57	4	M27617
Pathway	REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE	NCAN BCAN	4.43e-04	8	57	2	M27260
Pathway	REACTOME_DEFECTIVE_CHSY1_CAUSES_TPBS	NCAN BCAN	4.43e-04	8	57	2	M27261
Pathway	REACTOME_DEFECTIVE_CHST3_CAUSES_SEDCJD	NCAN BCAN	4.43e-04	8	57	2	M27259
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_GLYCOSAMINOGLYCAN_METABOLISM	ACAN NCAN BCAN	5.99e-04	41	57	3	M27257
Pubmed	Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes.	COL5A1 ACAN NCAN BCAN MMP3	5.28e-09	24	94	5	25344368
Pubmed	Lecticans: organizers of the brain extracellular matrix.	ACAN NCAN BCAN	7.63e-08	4	94	3	10766023
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIAA1671 KSR1 CCDC8 PANK2 NET1 ATXN1 CEP85L KIAA0232 PPFIA1 ARHGEF4 USP54 GNAS EPB41L2	5.70e-07	861	94	13	36931259
Pubmed	A functional variant within the MMP3 gene does not associate with human range of motion.	COL5A1 MMP3	7.23e-06	2	94	2	20359947
Pubmed	Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.	COL5A1 MMP3	7.23e-06	2	94	2	19042922
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4X NLGN4Y	7.23e-06	2	94	2	18434543
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4X NLGN4Y	7.23e-06	2	94	2	23183221
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4X NLGN4Y	7.23e-06	2	94	2	24855039
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4X NLGN4Y	7.23e-06	2	94	2	37001827
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4X NLGN4Y	7.23e-06	2	94	2	37080762
Pubmed	Role of the mismatch repair gene, Msh6, in suppressing genome instability and radiation-induced mutations.	MSH6 APRT	7.23e-06	2	94	2	18538799
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4X NLGN4Y	7.23e-06	2	94	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4X NLGN4Y	7.23e-06	2	94	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4X NLGN4Y	7.23e-06	2	94	2	24104404
Pubmed	ROCK inhibition enhances aggrecan deposition and suppresses matrix metalloproteinase-3 production in human articular chondrocytes.	ACAN MMP3	7.23e-06	2	94	2	24111521
Pubmed	NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1.	COL5A1 NAT10	7.23e-06	2	94	2	33941767
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4X NLGN4Y	7.23e-06	2	94	2	32243781
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4X NLGN4Y	7.23e-06	2	94	2	22989184
Pubmed	Muscleblind-like 1 is required for normal heart valve development in vivo.	ACAN NCAN BCAN	8.50e-06	15	94	3	26472242
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4X NLGN4Y	2.16e-05	3	94	2	32011705
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4X NLGN4Y	2.16e-05	3	94	2	18628683
Pubmed	Neurocan is dispensable for brain development.	NCAN BCAN	2.16e-05	3	94	2	11486035
Pubmed	Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins.	FNBP1L TRIP10	2.16e-05	3	94	2	16326391
Pubmed	Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma.	NCAN BCAN	2.16e-05	3	94	2	21997179
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4X NLGN4Y	2.16e-05	3	94	2	21282647
Pubmed	CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1.	SF3B1 CDK12	2.16e-05	3	94	2	37026485
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	MSH6 SF3B1 NMNAT1 NAT10 EHMT1 NKTR DDX10	3.28e-05	330	94	7	33301849
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CUX2 CDK12 KIAA0232 EHMT1 ARHGEF4 DSCAML1	3.47e-05	225	94	6	12168954
Pubmed	Associations of 25 structural, degradative, and inflammatory candidate genes with lumbar disc desiccation, bulging, and height narrowing.	COL5A1 ACAN MMP3	4.21e-05	25	94	3	19180518
Pubmed	Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components.	NCAN BCAN	4.32e-05	4	94	2	29367009
Pubmed	The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.	NCAN BCAN	4.32e-05	4	94	2	11027579
Pubmed	Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.	NCAN BCAN	4.32e-05	4	94	2	31558805
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4X NLGN4Y	4.32e-05	4	94	2	12669065
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4X NLGN4Y	4.32e-05	4	94	2	22671294
Pubmed	Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.	NCAN BCAN	4.32e-05	4	94	2	35721494
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4X NLGN4Y	4.32e-05	4	94	2	20579107
Pubmed	The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics.	FNBP1L TRIP10	4.32e-05	4	94	2	16630611
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4X NLGN4Y	4.32e-05	4	94	2	16077734
Pubmed	Extracellular matrix alterations in brains lacking four of its components.	NCAN BCAN	4.32e-05	4	94	2	15694392
Pubmed	Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.	NLGN4X NLGN4Y	4.32e-05	4	94	2	17292328
Pubmed	Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.	NCAN BCAN	4.32e-05	4	94	2	23637166
Pubmed	Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules.	NCAN BCAN	4.32e-05	4	94	2	28512860
Pubmed	Neural extracellular matrix regulates visual sensory motor integration.	NCAN BCAN	4.32e-05	4	94	2	38318351
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SDK2 SF3B1 PPFIA1 NAT10 GON4L PCARE	4.32e-05	234	94	6	36243803
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	MSH6 CTTNBP2 SF3B1 MRPS2 ARHGAP9 EPB41L2	4.43e-05	235	94	6	30258100
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KIAA1671 COL5A1 THEM4 ATXN1 NLGN4Y KIAA0232 NAT10 KNDC1 EHMT1 KYAT3 ARHGEF4 FNBP1L GNAS ARHGEF26	4.62e-05	1489	94	14	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	KIAA1671 MSH6 NET1 CDK12 MRPS2 PPFIA1 EHMT1 PPP1R18 GON4L ZC3H7B MBD4 EPB41L2 SEMA4C DDX10	4.89e-05	1497	94	14	31527615
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	MSH6 FNDC1 CCDC8 SF3B1 CDK12 MRPS2 SPEG PPFIA1 NAT10 SLBP GNAS	6.35e-05	971	94	11	33306668
Pubmed	The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.	ACAN BCAN	7.19e-05	5	94	2	11038354
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NLGN4X NLGN4Y	7.19e-05	5	94	2	18923512
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4X NLGN4Y	7.19e-05	5	94	2	10996085
Pubmed	RPTPζ/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1.	ACAN BCAN	7.19e-05	5	94	2	22728091
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4X NLGN4Y	7.19e-05	5	94	2	37865312
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	SF3B1 CCDC71 EHMT1	7.36e-05	30	94	3	17403666
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	KIAA1671 POMT2 IL16 NLGN4X DISP3 PPP1R18 ARHGAP9 LEMD1 MMP3 SMCO2	8.60e-05	832	94	10	36724073
Pubmed	The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?	NLGN4X NLGN4Y	1.08e-04	6	94	2	21838267
Pubmed	Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses.	NLGN4X NLGN4Y	1.08e-04	6	94	2	29724786
Pubmed	Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.	ACAN MMP3	1.08e-04	6	94	2	7998967
Pubmed	Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.	ACAN BCAN	1.08e-04	6	94	2	14550776
Pubmed	ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.	ACAN MMP3	1.08e-04	6	94	2	12054629
Pubmed	Circulating levels of interleukin-6, vascular endothelial growth factor, YKL-40, matrix metalloproteinase-3, and total aggrecan in spondyloarthritis patients during 3 years of treatment with TNFα inhibitors.	ACAN MMP3	1.08e-04	6	94	2	20640910
Pubmed	The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.	ACAN NCAN BCAN	1.08e-04	34	94	3	32220631
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NLGN4X NLGN4Y PPFIA1 NCAN GNAS EPB41L2	1.18e-04	281	94	6	28706196
Pubmed	Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.	FNBP1L TRIP10	1.50e-04	7	94	2	16418535
Pubmed	Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.	ACAN MMP3	1.50e-04	7	94	2	8216228
Pubmed	Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).	ACAN MMP3	1.50e-04	7	94	2	10922468
Pubmed	Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.	ACAN NCAN	1.50e-04	7	94	2	21976490
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	KIAA1671 KIAA0586 NKTR USP54	1.67e-04	101	94	4	24613305
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CTTNBP2 NAT10 KNDC1 SEMA4C	1.74e-04	102	94	4	11214970
Pubmed	Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.	NLGN4X NLGN4Y	2.00e-04	8	94	2	30871858
Pubmed	Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.	NLGN4X NLGN4Y	2.57e-04	9	94	2	23010509
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	NLGN4X NLGN4Y	2.57e-04	9	94	2	29252214
Pubmed	Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.	BCAN MMP3	2.57e-04	9	94	2	10986281
Pubmed	The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas.	VIPR2 CUX2 SDK2	3.03e-04	48	94	3	32386544
Pubmed	Morphological diversity of single neurons in molecularly defined cell types.	VIPR2 CUX2	3.21e-04	10	94	2	34616072
Pubmed	Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.	NCAN BCAN	3.21e-04	10	94	2	20950796
Pubmed	Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.	ADRA1D KCNH2	3.21e-04	10	94	2	21063774
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SF3B1 NMNAT1 CDK12 MRPS2 PPFIA1 NAT10 NKTR GNAS APRT EPB41L2 MX2 DDX10	3.24e-04	1371	94	12	36244648
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	SDK2 DSCAML1 SEMA4C	3.84e-04	52	94	3	26633812
Pubmed	SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.	NLGN4X NLGN4Y	3.91e-04	11	94	2	32973045
Pubmed	CRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication.	SF3B1 SLBP	3.91e-04	11	94	2	27203182
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	NLGN4X NLGN4Y	3.91e-04	11	94	2	26403076
Pubmed	Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.	ACAN MMP3	4.69e-04	12	94	2	36047655
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	IL16 CTTNBP2 SF3B1 PPFIA1 NCAN KNDC1 PPP1R18 BCAN ARHGEF4 USP54 EPB41L2 DNAH11	4.76e-04	1431	94	12	37142655
Pubmed	Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.	SH2D1B CEP85L KCNH2	5.03e-04	57	94	3	24952745
Pubmed	Advancing the understanding of autism disease mechanisms through genetics.	NLGN4X NLGN4Y	5.53e-04	13	94	2	27050589
Pubmed	O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.	YIF1B SF3B1 CDK12 EHMT1 GNAS	6.46e-04	254	94	5	36604567
Pubmed	Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.	NLGN4X NLGN4Y	7.42e-04	15	94	2	18227507
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CDK12 KCNH2 SPEG APBB3 EHMT1 FLCN ARHGEF4 ZC3H7B IQCE ANKRD16	8.15e-04	1105	94	10	35748872
Pubmed	Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling.	ACAN GNAS	8.46e-04	16	94	2	30111653
Pubmed	Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.	MSH6 EHMT1	8.46e-04	16	94	2	28803780
Pubmed	Global comparative transcriptome analysis of cartilage formation in vivo.	ACAN KLF2	8.46e-04	16	94	2	19272164
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	KIAA1671 MSH6 ADRA1D ARHGAP9 PCARE DSCAML1 EPB41L2 IQCE	8.71e-04	736	94	8	29676528
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	KIAA1671 KSR1 MSH6 IL16 NET1 ATXN1 PPFIA1 NAT10 EHMT1 USP54	8.78e-04	1116	94	10	31753913
Pubmed	Maturational disturbance of chondrocytes in Cbfa1-deficient mice.	COL5A1 ACAN	9.57e-04	17	94	2	10213384
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	MSH6 SF3B1 CDK12 NAT10 DDX10	1.05e-03	283	94	5	30585729
Pubmed	Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.	ACAN BCAN	1.08e-03	18	94	2	12684764
Pubmed	TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.	NRK GON4L	1.20e-03	19	94	2	31797533
Pubmed	Impact of ancestry and common genetic variants on QT interval in African Americans.	CEP85L KCNH2	1.20e-03	19	94	2	23166209
Pubmed	ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.	ATXN1 MMP3	1.20e-03	19	94	2	22014525
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	SPDYE11 SPDYE17 SPDYE10 SPDYE13 SPDYE15 SPDYE8 SPDYE9 SPDYE12 SPDYE14	6.31e-09	271	96	9	chr7q11
Cytoband	7q11.23	SPDYE10 SPDYE8 SPDYE9 SPDYE14	5.36e-05	97	96	4	7q11.23
Cytoband	20q13.3	OGFR GNAS	8.02e-04	20	96	2	20q13.3
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN NCAN BCAN	1.25e-07	4	58	3	574
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN NCAN BCAN	3.06e-04	41	58	3	1298
GeneFamily	CUT class homeoboxes and pseudogenes	ONECUT2 CUX2	3.59e-04	9	58	2	527
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE8 SPDYE9	6.54e-04	12	58	2	756
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	ACAN NCAN BCAN	8.11e-04	57	58	3	1179
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 ARHGEF4 ARHGEF26	1.24e-03	66	58	3	722
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	FNBP1L TRIP10	2.45e-03	23	58	2	1288
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 ARHGAP9 ARHGEF4 ARHGEF26	4.30e-03	206	58	4	682
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 SDK2 DPY19L2 ACAN NRK SLC30A8 DSCAML1	1.96e-07	200	92	7	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 SDK2 DPY19L2 ACAN NRK SLC30A8 DSCAML1	1.96e-07	200	92	7	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC9A2 SDK2 CTTNBP2 DPY19L2 NLGN4X KCNH2	2.02e-06	180	92	6	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 NRK DISP3 CHRM1 DSCAML1 DNAH11	2.30e-06	184	92	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 NRK DISP3 CHRM1 DSCAML1 DNAH11	2.30e-06	184	92	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 NRK DISP3 CHRM1 DSCAML1 DNAH11	2.30e-06	184	92	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	moderate-Epithelial-Ionocyte\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC9A2 SDK2 CTTNBP2 DPY19L2 NLGN4X KCNH2	2.52e-06	187	92	6	3e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCell	moderate-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC9A2 SDK2 CTTNBP2 DPY19L2 NLGN4X KCNH2	2.68e-06	189	92	6	6011b747e27d61d222380a7bffdd921a68e9b657
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VIPR2 ADRA1D NET1 ACAN SPEG	1.60e-05	152	92	5	0cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VIPR2 ADRA1D NET1 ACAN SPEG	1.60e-05	152	92	5	ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL5A1 FNDC1 CCDC8 NAALADL1 NET1	2.17e-05	162	92	5	3f264263878af630921911c2b344ac56eb1e7099
ToppCell	Basal_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CUX2 SDK2 NLGN4Y ACAN MMP3	2.59e-05	168	92	5	48089fa2d4a0f31a72405717119b767a92571f01
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THEMIS2 VIPR2 CUX2 SDK2 ARHGAP9	2.82e-05	171	92	5	39c8ae139e449217091e1481eb5e2aafb8f69a1c
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	THEMIS2 VIPR2 SH2D1B TTC16 KLF2	2.90e-05	172	92	5	701de463f85aaad3a4b36a0d5fbc416406620089
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CTTNBP2 NET1 FNBP1L TRIP10 EPB41L2	3.32e-05	177	92	5	e68ad19963a3d8917dfdb81127a41c4fcbe61dd5
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC9A2 CTTNBP2 DPY19L2 NLGN4X KCNH2	3.32e-05	177	92	5	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	Somatosensory_Cortex_(S1)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 SLC9A2 ATXN1 NLGN4Y	3.50e-05	179	92	5	82348bf56a4525b2f485696cab5b2ea6e96c2f91
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DISP3 BCAN ASIC4 C20orf144 DSCAML1	3.60e-05	180	92	5	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DISP3 BCAN ASIC4 C20orf144 DSCAML1	3.60e-05	180	92	5	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	IL16 SH2D1B C2CD4D ARHGAP9 C20orf144	3.79e-05	182	92	5	6bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCell	wk_08-11-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SDK2 ACAN KIAA0232 NRK DSCAML1	3.79e-05	182	92	5	00a148b1e499bf16325491536d187d4dd6b70c06
ToppCell	NS-critical-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC9A2 SDK2 CTTNBP2 DPY19L2 KCNH2	3.89e-05	183	92	5	ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 CTTNBP2 NRK DSCAML1 DNAH11	3.89e-05	183	92	5	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	critical-Epithelial-Ionocyte\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC9A2 SDK2 CTTNBP2 DPY19L2 KCNH2	3.99e-05	184	92	5	58d36577eff814d46d72f031f3533d71549e3d6e
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-T_cells-NK_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL16 SH2D1B PPP1R18 ARHGAP9 KLF2	4.21e-05	186	92	5	e083356f72995645f873ca0157d56bea5e942044
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR2 ACAN NCAN BCAN ASIC4	4.42e-05	188	92	5	7471c194276161422326647f09022e94f3d1640c
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR2 ACAN NCAN BCAN ASIC4	4.42e-05	188	92	5	053c251d3ddbeb866f34565aefca4535517b4387
ToppCell	Mesenchymal-chondrocyte\|World / Lineage, Cell type, age group and donor	COL5A1 FNDC1 SDK2 ACAN NRK	4.42e-05	188	92	5	7b1e3f8a941eaa68e89c562129a92314642eec66
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ONECUT2 KCNH2 FNBP1L GNAS DSCAML1	4.54e-05	189	92	5	8e6b6025f5554672e26a5d19fe365acb4333789c
ToppCell	critical-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC9A2 SDK2 CTTNBP2 DPY19L2 KCNH2	4.65e-05	190	92	5	05a2c3549b68f49081723bf35db14974274419d5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 FNDC1 ACAN SPEG EPB41L2	4.65e-05	190	92	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FNDC1 SDK2 ACAN NRK KLF2	4.77e-05	191	92	5	273c4a757292a9301de0eaeacdec91c9866be229
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D\|343B / Donor, Lineage, Cell class and subclass (all cells)	IL16 SH2D1B PPP1R18 ARHGAP9 KLF2	4.77e-05	191	92	5	2bd4ba4aaa0f4885079516156b409df527ab22f4
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL16 SH2D1B PPP1R18 ARHGAP9 KLF2	4.89e-05	192	92	5	fd7f034f0d5a5d577dc9e26a15856f5defbdef43
ToppCell	18-Distal-Immune-Hematopoietic,_Natural_Killer_Cell\|Distal / Age, Tissue, Lineage and Cell class	THEMIS2 IL16 SH2D1B PPP1R18 ARHGAP9	4.89e-05	192	92	5	dd47d47d0a7219771b275c4cf5f2b768424216c8
ToppCell	11.5-Airway-Mesenchymal-Cartilage\|Airway / Age, Tissue, Lineage and Cell class	FNDC1 SDK2 ACAN NRK KLF2	5.01e-05	193	92	5	d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 VIPR2 IL16 ARHGEF26 EPB41L2	5.01e-05	193	92	5	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	5'-Adult-LymphNode-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THEMIS2 IL16 HAGHL PPP1R18 KLF2	5.26e-05	195	92	5	8f5dfcdaccb0c8318f90a33519a8d6d98ba22943
ToppCell	5'-Adult-LymphNode-Hematopoietic-B_cells-Memory_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THEMIS2 IL16 HAGHL PPP1R18 KLF2	5.26e-05	195	92	5	e98217f9cf8c9574af66a1d8953101119c89c8a1
ToppCell	BAL-Control-cDC_10\|Control / Compartment, Disease Groups and Clusters	NET1 NLGN4Y ZC3H7B TRIP10 DNAH11	5.39e-05	196	92	5	c32b7b7e6a4781c19c30c6e32d5563f82355deb0
ToppCell	Mesenchymal_cells-Fibro/Chondro_p.\|World / Lineage and Cell class	SDK2 ACAN NRK MMP3 KLF2	5.39e-05	196	92	5	ddc168849e0e97005a111be004463bb72d433853
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn\|World / Primary Cells by Cluster	CUX2 CTTNBP2 CEP85L DISP3 FNBP1L	5.39e-05	196	92	5	9401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-B_cells-Memory_B\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THEMIS2 IL16 HAGHL ARHGAP9 KLF2	5.39e-05	196	92	5	c7363794fb731848e4343b3a4e4f800f9c81999a
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FNDC1 SDK2 ACAN NRK MMP3	5.66e-05	198	92	5	c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCell	Tracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FNDC1 SDK2 ACAN NRK MMP3	5.66e-05	198	92	5	55f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	VIPR2 KSR1 KCNH2 ACAN SPEG	5.66e-05	198	92	5	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 SDK2 ACAN NRK SLC30A8	5.93e-05	200	92	5	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL16 SDK2 ACAN NRK SLC30A8	5.93e-05	200	92	5	7c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TTC16 DISP3 ASIC4 MX2	7.46e-05	108	92	4	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FNDC1 SLC9A2 ACAN SPEG	1.23e-04	123	92	4	87401764a073c1808f214642a9c84299c78f7ec7
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL5A1 FNDC1 NET1 APBB3	1.92e-04	138	92	4	8d70e64843f7c3be8ee4203cc126fdf1001f0df5
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	FNDC1 ATXN1 TTC16 KLF2	2.26e-04	144	92	4	a4bb274d553c29c8299354de757ecc5634008c68
ToppCell	Globus_pallidus-Hematopoietic\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	THEMIS2 IL16 ARHGAP9 C20orf144	3.07e-04	156	92	4	67cdaadc3b917f7072adce16c0391472c14a2563
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADRA1D NET1 LEMD1 MBD4	3.14e-04	157	92	4	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	COL5A1 SDK2 KCNH2 C20orf144	3.29e-04	159	92	4	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	VIPR2 PPP1R18 BCAN SEMA4C	3.29e-04	159	92	4	57df5c9b678a15eb5e025e1a80de2e6769cc13d5
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL5A1 CTTNBP2 NLGN4X KCNH2	3.37e-04	160	92	4	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	NS-critical-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL5A1 CTTNBP2 NLGN4X KCNH2	3.37e-04	160	92	4	c61869d9dbba250270e59366e15af204e5b4395d
ToppCell	Influenza_Severe-cDC\|World / Disease group and Cell class	CTTNBP2 DPY19L2 NET1 KCNH2	3.70e-04	164	92	4	c984228f73b9aa1aaf948541f64f41ed874770cd
ToppCell	NS-moderate-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CTTNBP2 KCNH2 BCAN ASIC4	3.70e-04	164	92	4	35c673380f75cb4bfe080089bc723c4373bcc7a5
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	COL5A1 SDK2 KCNH2 C20orf144	3.70e-04	164	92	4	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DPY19L2 NET1 TRIP10 DNAH11	3.70e-04	164	92	4	eae6d440877b292ad18dc4bd02802dda5b2f9c60
ToppCell	critical-Myeloid-Mast_cell\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CTTNBP2 KCNH2 BCAN ASIC4	3.79e-04	165	92	4	34a1cc6ccd46c059354e8fbde1ac69f202695a4e
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THEMIS2 SLC9A2 DPY19L2 NLGN4X	3.79e-04	165	92	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	Influenza_Severe-cDC\|Influenza_Severe / Disease group and Cell class	CTTNBP2 DPY19L2 NET1 KCNH2	3.88e-04	166	92	4	b40bdf0f7f381e25be61188e9f6c294d25a8b824
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	THEMIS2 SLC9A2 DPY19L2 NLGN4X	3.88e-04	166	92	4	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	COL5A1 CUX2 CEP85L NKTR	3.97e-04	167	92	4	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	NS-critical-d_07-13-Myeloid-Mast_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CTTNBP2 KCNH2 BCAN ASIC4	3.97e-04	167	92	4	8a14fd980d8ebe8ef0216221f619d31aaa27ff15
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like\|GI_small-bowel / Manually curated celltypes from each tissue	SDK2 NLGN4Y ACAN C2CD4D	3.97e-04	167	92	4	3ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCell	Adult-Immune-natural_killer_cell-D122\|Adult / Lineage, Cell type, age group and donor	SH2D1B TTC16 ARHGAP9 KLF2	3.97e-04	167	92	4	ff1ce3b1a2d91d2ad979f25899db4f4eeb865892
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	THEMIS2 SLC9A2 DPY19L2 NLGN4X	4.06e-04	168	92	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-NK_T_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SH2D1B KNDC1 PPP1R18 ARHGAP9	4.06e-04	168	92	4	b4b73f3fc9f4c3d87ca0a63ff8b2842141ccd0e6
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KSR1 CCDC8 TTC16 DNAH11	4.15e-04	169	92	4	8bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CUX2 KCNH2 GNAS ASIC4	4.15e-04	169	92	4	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FNDC1 KCNH2 GNAS ASIC4	4.15e-04	169	92	4	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL16 SH2D1B PPP1R18 ARHGAP9	4.15e-04	169	92	4	a3234904d7ff8f451ca894e93badd61d75e3cd2a
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|390C / Donor, Lineage, Cell class and subclass (all cells)	TTC16 SLC30A8 PPP1R18 KLF2	4.34e-04	171	92	4	d6d8ea45b443d95f64720c9bc07d324148f5b239
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR2 NAALADL1 TTC16 PPP1R18	4.43e-04	172	92	4	b440184f2d98d2f2d59566795f44fb79c0647ca4
ToppCell	droplet-Limb_Muscle-nan-24m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SF3B1 SLBP KLF2 SEMA4C	4.43e-04	172	92	4	770e4c5467ef2eaddf883723fb0aa1226973b000
ToppCell	COVID-19_Mild-PLT_2\|COVID-19_Mild / Disease Group and Platelet Clusters	EVI5 SDK2 KIAA0586 APRT	4.53e-04	173	92	4	d11705e56b6b21eec963ea224717f27680c781ed
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	POMT2 KIAA0232 C2CD4D BCAN	4.53e-04	173	92	4	23e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NLGN4Y BCAN DSCAML1 DNAH11	4.63e-04	174	92	4	16204ff504b7b382b4d90ca35003ad5336020e07
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 KIAA1671 SH2D1B SLC18B1	4.63e-04	174	92	4	99eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	KIAA1671 IL16 ARHGAP9 MX2	4.73e-04	175	92	4	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 SDK2 SH2D1B SLC18B1	4.73e-04	175	92	4	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	KIAA1671 IL16 ARHGAP9 MX2	4.73e-04	175	92	4	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells-NK_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL16 SH2D1B TTC16 ARHGAP9	4.73e-04	175	92	4	d427c1eaea805046b1e4944d374adc7095f710a1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 CTTNBP2 DSCAML1 DNAH11	4.84e-04	176	92	4	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 SDK2 SH2D1B SLC18B1	4.84e-04	176	92	4	e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 CTTNBP2 DSCAML1 DNAH11	4.94e-04	177	92	4	da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAN GNAS ASIC4 DNAH11	4.94e-04	177	92	4	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 SDK2 SH2D1B SLC18B1	4.94e-04	177	92	4	bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCAN GNAS ASIC4 DNAH11	4.94e-04	177	92	4	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NET1 SPEG MBD4 DNAH11	5.05e-04	178	92	4	de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 SDK2 SH2D1B SLC18B1	5.05e-04	178	92	4	431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL5A1 CTTNBP2 DSCAML1 DNAH11	5.05e-04	178	92	4	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 SDK2 SH2D1B SLC18B1	5.15e-04	179	92	4	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THEMIS2 SDK2 SH2D1B SLC18B1	5.15e-04	179	92	4	f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	THEMIS2 VIPR2 IL16 CUX2	5.15e-04	179	92	4	4808469096cd6bec2bdfcf4fc55aa324757600c3
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL16 SH2D1B TTC16 ARHGAP9	5.15e-04	179	92	4	e717c0079b788a3703c0a450922bd5a2bdc322a0
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	COL5A1 VIPR2 OGFR KIAA0586 FLCN MBD4 ARHGEF26 KLF2	1.10e-06	198	89	8	7003_DN
Drug	Etilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; PC3; HT_HG-U133A	VIPR2 ADRA1D SLC9A2 ATXN1 SPEG BCAN ZC3H7B	1.19e-05	196	89	7	4590_DN
Drug	Metoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Up 200; 5.8uM; PC3; HT_HG-U133A	COL5A1 KCNH2 ACAN ARHGEF4 ZC3H7B ARHGEF26 MX2	1.19e-05	196	89	7	4508_UP
Drug	Aminohippuric acid [61-78-9]; Up 200; 20.6uM; MCF7; HT_HG-U133A	THEMIS2 COL5A1 ADRA1D OGFR ARHGEF4 ZC3H7B IQCE	1.23e-05	197	89	7	5394_UP
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A	KSR1 ADRA1D YIF1B KCNH2 OGFR EHMT1 ZC3H7B	1.23e-05	197	89	7	6055_DN
Drug	Natamycin [7681-93-8]; Up 200; 6uM; PC3; HT_HG-U133A	ONECUT2 COL5A1 KSR1 IL16 GNAS ZC3H7B ARHGEF26	1.23e-05	197	89	7	5809_UP
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; PC3; HT_HG-U133A	EVI5 COL5A1 VIPR2 PRR14 SLC9A2 FLCN GON4L	1.28e-05	198	89	7	4592_DN
Drug	L696,418	ACAN MMP3	1.51e-05	2	89	2	CID000132967
Drug	furmethide	GNAS CHRM1	4.52e-05	3	89	2	CID000010937
Drug	sertindole	ADRA1D KCNH2	9.02e-05	4	89	2	ctd:C066304
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; PC3; HT_HG-U133A	VIPR2 ADRA1D OGFR MMP3 ZC3H7B SEMA4C	1.05e-04	191	89	6	3823_DN
Drug	Midodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; MCF7; HT_HG-U133A	VIPR2 YIF1B FLCN NKTR ARHGEF4 ZC3H7B	1.05e-04	191	89	6	2250_DN
Drug	PNU-0251126 [267429-19-6]; Down 200; 10uM; PC3; HT_HG-U133A	SPEG FLCN NKTR ZC3H7B ARHGEF26 EPB41L2	1.11e-04	193	89	6	7388_DN
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	OGFR KIAA0586 NKTR ZC3H7B IQCE SEMA4C	1.18e-04	195	89	6	999_DN
Drug	Pergolide mesylate [66104-23-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	ONECUT2 COL5A1 VIPR2 OGFR FLCN ZC3H7B	1.18e-04	195	89	6	7434_UP
Drug	Trichlormethiazide [133-67-5]; Down 200; 10.6uM; PC3; HT_HG-U133A	ONECUT2 COL5A1 VIPR2 SLC9A2 OGFR NKTR	1.18e-04	195	89	6	4198_DN
Drug	Nefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; MCF7; HT_HG-U133A	THEMIS2 POMT2 COL5A1 SPEG ZC3H7B ARHGEF26	1.18e-04	195	89	6	2317_UP
Drug	Calycanthine [595-05-1]; Down 200; 11.6uM; PC3; HT_HG-U133A	EVI5 KCNH2 OGFR FLCN ARHGEF4 ZC3H7B	1.18e-04	195	89	6	5744_DN
Drug	Arcaine sulfate [14923-17-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	POMT2 YIF1B KCNH2 OGFR GON4L MMP3	1.21e-04	196	89	6	4974_UP
Drug	Methylhydantoin-5-(L) [40856-73-3]; Down 200; 35uM; HL60; HT_HG-U133A	OGFR GON4L ZC3H7B MX2 KLF2 SEMA4C	1.21e-04	196	89	6	3040_DN
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A	VIPR2 OGFR FLCN GNAS IQCE KLF2	1.21e-04	196	89	6	5700_DN
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Down 200; 12.8uM; PC3; HT_HG-U133A	EVI5 VIPR2 SLC9A2 NKTR ZC3H7B ARHGEF26	1.21e-04	196	89	6	4208_DN
Drug	Bambuterol hydrochloride [81732-46-9]; Down 200; 10uM; MCF7; HT_HG-U133A	VIPR2 KCNH2 OGFR ARHGEF4 ZC3H7B ARHGEF26	1.21e-04	196	89	6	3199_DN
Drug	Guanadrel sulfate [22195-34-2]; Up 200; 7.6uM; MCF7; HT_HG-U133A	ONECUT2 COL5A1 KCNH2 FLCN ZC3H7B KLF2	1.21e-04	196	89	6	4720_UP
Drug	Protoveratrine A [143-57-7]; Up 200; 5uM; MCF7; HT_HG-U133A	VIPR2 OGFR SPEG FLCN NKTR MMP3	1.21e-04	196	89	6	4963_UP
Drug	Bicuculline (+) [485-49-4]; Down 200; 10.8uM; PC3; HT_HG-U133A	EVI5 COL5A1 ADRA1D SLC9A2 FLCN BCAN	1.21e-04	196	89	6	4574_DN
Drug	Isocarboxazid [59-63-2]; Up 200; 17.2uM; HL60; HT_HG-U133A	POMT2 ONECUT2 KSR1 OGFR GNAS KLF2	1.21e-04	196	89	6	2562_UP
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	ONECUT2 VIPR2 KSR1 IL16 SLC9A2 ARHGEF26	1.24e-04	197	89	6	7283_UP
Drug	aspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A_EA	THEMIS2 POMT2 VIPR2 YIF1B OGFR ZC3H7B	1.24e-04	197	89	6	984_UP
Drug	Dicloxacillin sodium salt [13412-64-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A	EVI5 ONECUT2 VIPR2 SPEG BCAN KLF2	1.24e-04	197	89	6	3307_UP
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A	YIF1B KCNH2 OGFR ACAN GNAS IQCE	1.28e-04	198	89	6	1493_UP
Drug	Paroxetine maleate [64006-44-6]; Up 200; 1uM; MCF7; HT_HG-U133A	KSR1 NLGN4X SPEG KIAA0586 ZC3H7B MX2	1.28e-04	198	89	6	3904_UP
Drug	Pizotifen malate [5189-11-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A	KCNH2 OGFR ACAN SPEG KIAA0232 KLF2	1.28e-04	198	89	6	5491_UP
Drug	5194442; Down 200; 20uM; MCF7; HT_HG-U133A	POMT2 ONECUT2 BCAN ARHGEF4 ARHGEF26 EPB41L2	1.28e-04	198	89	6	6599_DN
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	OGFR KIAA0232 FLCN BCAN ZC3H7B KLF2	1.28e-04	198	89	6	7549_UP
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; PC3; HT_HG-U133A	ADRA1D SLC9A2 OGFR FLCN MMP3 ZC3H7B	1.28e-04	198	89	6	3987_DN
Drug	DO 897/99; Down 200; 8.2uM; MCF7; HT_HG-U133A	KCNH2 OGFR FLCN ARHGEF4 IQCE KLF2	1.28e-04	198	89	6	2877_DN
Drug	Diperodon hydrochloride [537-12-2]; Up 200; 9.2uM; PC3; HT_HG-U133A	COL5A1 VIPR2 KCNH2 MMP3 ARHGEF26 MX2	1.28e-04	198	89	6	4498_UP
Drug	Hexetidine [141-94-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	COL5A1 MSH6 YIF1B CDK12 KIAA0586 ZC3H7B	1.28e-04	198	89	6	5420_DN
Drug	Prednicarbate [73771-04-7]; Up 200; 8.2uM; MCF7; HT_HG-U133A	VIPR2 ADRA1D NLGN4X SPEG EHMT1 ZC3H7B	1.32e-04	199	89	6	5544_UP
Drug	Pirmenolum	KCNH2 ASIC4 CHRM1	1.41e-04	26	89	3	CID000004853
Disease	Adenocarcinoma of large intestine	MSH6 CDK12 NRK FLCN	1.66e-04	96	84	4	C1319315
Disease	Malignant neoplasm of breast	THEMIS2 MSH6 SLC9A2 NET1 CEP85L EHMT1 ARHGEF4 USP54 MMP3 APRT DDX10	2.31e-04	1074	84	11	C0006142
Disease	X-18921 measurement	THEM4 C2CD4D	2.85e-04	9	84	2	EFO_0800796
Disease	blood urea nitrogen measurement	CUX2 CDK12 GON4L KYAT3 LEMD1 GNAS ARHGEF26	3.10e-04	452	84	7	EFO_0004741
Disease	Optic Atrophy	NMNAT1 SLBP	3.55e-04	10	84	2	C0029124
Disease	degenerative disc disease (biomarker_via_orthology)	ACAN MMP3	4.33e-04	11	84	2	DOID:90 (biomarker_via_orthology)
Disease	systemic lupus erythematosus	EVI5 KSR1 PRR14 ATXN1 CDK12 ARHGAP9 MBD4 ANKRD16 KLF2	4.50e-04	799	84	9	MONDO_0007915
Disease	creatinine measurement	CUX2 SLC9A2 CDK12 OGFR SPEG KYAT3 GNAS ASIC4 MBD4 ARHGEF26	5.25e-04	995	84	10	EFO_0004518
Disease	urate measurement	CUX2 NAALADL1 GON4L FNBP1L GNAS ARHGEF26 CHRM1 EPB41L2 IQCE	1.01e-03	895	84	9	EFO_0004531
Disease	Lung diseases	FLCN DNAH11 KLF2	1.45e-03	78	84	3	C0024115
Disease	colorectal carcinoma (is_implicated_in)	MSH6 MBD4	1.78e-03	22	84	2	DOID:0080199 (is_implicated_in)
Disease	breast cancer, COVID-19	CUX2 GON4L	1.78e-03	22	84	2	MONDO_0007254, MONDO_0100096
Disease	Coronary heart disease	MMP3 DNAH11	2.12e-03	24	84	2	C0010068
Disease	inflammatory bowel disease (implicated_via_orthology)	IL16 EPB41L2	2.30e-03	25	84	2	DOID:0050589 (implicated_via_orthology)
Disease	body surface area	HAGHL KCNH2 ACAN SLBP GNAS ARHGEF26 EPB41L2	2.40e-03	643	84	7	EFO_0022196

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGVPSRRKSRLERWS	nan	101	A8MUN3
CAKKPWRSGPRSAQR	GNAS	586	P84996
EKKRRGSGVPWASRP	DISP3	806	Q9P2K9
PKRRSRSPHRKWSDS	CDK12	216	Q9NYV4
PGAWKTESKIRRTPL	ANKRD16	161	Q6P6B7
PRRKPSTFWHSISRL	ARHGEF4	671	Q9NR80
LAPRGRVPKDRSWKA	DNAH11	3226	Q96DT5
PFPLVSSSRWLVKRG	ARHGEF26	646	Q96DR7
IEPSKPAATRKRRWS	ATXN1	761	P54253
GSVSEILARPKPWRK	CUX2	586	O14529
IRKRGKLPGPTLWAS	APRT	86	P07741
LSWAKARPLSRRGKR	HAGHL	196	Q6PII5
PYLSKPRKVASWRSL	IQCE	46	Q6IPM2
PSKGRRWAARAPSTR	LEMD1	111	Q68G75
TPGPNWDFTLKRKRR	NET1	56	Q7Z628
PSRRAVLGSPRVKWT	BCAN	66	Q96GW7
PRSPWKPGTLRDKSR	KIAA1671	556	Q9BY89
GSWQPRKLPVFKSLR	FLCN	336	Q8NFG4
PTSWLAPGRAKTFRL	KCNH2	151	Q12809
RTFPGIPKWRKTHLT	MMP3	101	P08254
SRGISRFIPPWLKKQ	EPB41L2	71	O43491
RHKPEGKIRPRSWSS	KIAA0232	276	Q92628
LPSSRRPWRGPISRK	KSR1	581	Q8IVT5
RHLARTTGRWKDPPK	EVI5	541	O60447
APKPAWFRQSLKGLR	IL16	786	Q14005
LLRNPKPWSKLKSGR	ONECUT2	371	O95948
RAPSWRKKFRPKDIR	PPFIA1	1136	Q13136
VWRRPKTPLRTSTGG	ASIC4	476	Q96FT7
KLPRGSWRSSPGRIQ	DPY19L2	46	Q6NUT2
DSPTRGWVSKRLLKP	MSH6	136	P52701
TPRLLKFWKRAGFVP	NAT10	716	Q9H0A0
TAPLAPRIKWSRVSK	ACAN	66	P16112
VESLRKKRPLFPWFG	PANK2	201	Q9BZ23
RRSPAKIWPTTKRPA	NLGN4Y	626	Q8NFZ3
IWGLRPPKGRSFSSL	APBB3	76	O95704
PKKRTRLGPRSPKAW	CCDC71	401	Q8IV32
KPRIPSFRSLKRGWS	FNBP1L	371	Q5T0N5
SPRRKSGRFSLPTWN	CTTNBP2	1461	Q8WZ74
KDGRPLPADSRWTKR	DSCAML1	261	Q8TD84
AWKAPRLSGAKSPRR	FNDC1	176	Q4ZHG4
GLNRWKRFTRKPSPK	CCDC191	16	Q8NCU4
LKPVATRFPRKAWRQ	GON4L	981	Q3T8J9
PAARWAPSGLFSKRR	C2CD4D	16	B7Z1M9
RWRKIPKRPGSVHRT	CHRM1	441	P11229
RPLRKWSSLSKLTAP	CEP85L	151	Q5SZL2
RWKARSALRPGAPLL	COL5A1	6	P20908
LSWPRLLSRFRSPGK	C20orf144	116	Q9BQM9
ALSPPRRKAFKKWTP	MBD4	426	O95243
RRKAFKKWTPPRSPF	MBD4	431	O95243
EDGISRKSFPWRLPR	KNDC1	1406	Q76NI1
GARPDPVRSFNRWKK	DDX10	11	Q13206
KRRRAFWHTPRLPTL	CCDC8	491	Q9H0W5
KWRLSPGETPERSLR	PPP1R18	191	Q6NYC8
TWFRDGRKIPPSSRI	SDK2	146	Q58EX2
GKTDSPWIKPARKRR	EHMT1	431	Q9H9B1
RRSPAKIWPTTKRPA	NLGN4X	626	Q8N0W4
IPLRSKPVYGKRWSS	KYAT3	176	Q6YP21
GPTRRTWASPKLRAS	PCARE	871	A6NGG8
WGPQDKLRRFKPSSL	OGFR	286	Q9NZT2
PKRFRAKSSWRPEKL	NRK	701	Q7Z2Y5
PPSPARWSLGRKRRA	SLBP	21	Q14493
SPKRPAWGSRRFEAV	POMT2	41	Q9UKY4
FGLLSDKRPPLRKWL	SLC18B1	291	Q6NT16
RLRAYRPPSGEKWSK	NKTR	371	P30414
RPSAARDAPRIKWTK	NCAN	66	O14594
TRALWGARSPKRPRL	PRR14	21	Q9BWN1
PPRRSLGWKRKRECL	SPDYE10	51	P0DUX0
PPRRSLGWKRKRECL	SPDYE11	51	P0DTA3
PPRRSLGWKRKRECL	SPDYE8	51	P0DUD1
PRWSRPLLVKKGTNF	SEMA4C	406	Q9C0C4
RWLGFLGKATPRPAR	MRPS2	21	Q9Y399
IKRTSPSLRWRGLKL	SH2D1B	101	O14796
SRRKPPSAFREWRLL	ADRA1D	486	P25100
SRTKRWPFGKKNKPR	TRIP10	316	Q15642
LWLSSKPPSKRLTFG	SLC30A8	121	Q8IWU4
AGTPRLRKWPSKRRI	YIF1B	11	Q5BJH7
RWGFSRPRKDKGLSP	SPEG	2546	Q15772
PRLVWRASEPGSRKA	SLC9A2	791	Q9UBY0
GSWKRLPSYKRTPTE	THEM4	71	Q5T1C6
GAAASQPPSKRKRRW	SF3B1	186	O75533
PPRRSLGWKRKRECL	SPDYE12	51	P0DUX1
PPRRSLGWKRKRECL	SPDYE13	51	A0A494C0Z2
PPRRSLGWKRKRECL	SPDYE14	51	P0DUD3
PPRRSLGWKRKRECL	SPDYE15	51	P0DUD4
PPRRSLGWKRKRECL	SPDYE17	51	P0DUD2
SPPWRVLASSKGRKV	THEMIS2	296	Q5TEJ8
LTGCKSWKPPRRSRS	ARHGAP9	236	Q9BRR9
SPPRNTAWKRALRIF	SMCO2	271	A6NFE2
LKRKWRSRCPTPSAS	VIPR2	386	P41587
PPRRSLGWKRKRECL	SPDYE9	51	A0A494C191
RPRKVKAARGRSWRP	TTC16	771	Q8NEE8
RSKIGWTPEKTNRFP	KIAA0586	391	Q9BVV6
SSSSSKYRPTWRPKR	USP54	566	Q70EL1
WKRIRPRPTKTSFVG	ZC3H7B	466	Q9UGR2
KPKRGRRSWPRKRTA	KLF2	256	Q9Y5W3
KPWPYRRRSQFSSRK	MX2	6	P20592
RVLGTLLKKGTWRPR	NAALADL1	391	Q9UQQ1
LLKKGTWRPRRSIVF	NAALADL1	396	Q9UQQ1
NSPTLERPGRKRKWT	NMNAT1	116	Q9HAN9