Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	NPBWR1 OPRD1 OPRM1	3.60e-06	7	95	3	GO:0004985
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC24A5 SLC17A2 SLC13A2 SLC18A1 SCN7A SLC4A5	1.67e-04	171	95	6	GO:0015081
GeneOntologyMolecularFunction	G protein-coupled receptor activity	VN1R4 NPBWR1 HTR1A TMIGD3 P2RY8 ADGRG4 BDKRB2 OPRD1 OPRM1 LPAR6 OR1E3 HRH1 OR7A17	2.78e-04	884	95	13	GO:0004930
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH2 DNAH1 HOOK1	3.14e-04	28	95	3	GO:0051959
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC24A5 SLC17A2 SLC13A2 OPRM1 KCNC3 SLC18A1 SCN7A HRH1 SLC4A5	3.73e-04	465	95	9	GO:0046873
GeneOntologyMolecularFunction	peptide receptor activity	NPBWR1 BDKRB2 OPRD1 OPRM1 GUCY2F	5.51e-04	140	95	5	GO:0001653
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC17A2 SLC13A2 SLC18A1 SLC4A5	6.04e-04	81	95	4	GO:0015370
GeneOntologyMolecularFunction	neuropeptide binding	NPBWR1 OPRD1 OPRM1	7.21e-04	37	95	3	GO:0042923
GeneOntologyMolecularFunction	symporter activity	SLC24A5 SLC17A2 SLC13A2 SLC18A1 SLC4A5	7.53e-04	150	95	5	GO:0015293
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC24A5 SLC17A2 AQP10 SLC13A2 OPRM1 CLIC5 KCNC3 SLC18A1 SCN7A HRH1 SLC4A5	9.42e-04	758	95	11	GO:0015318
Domain	Opioid_rcpt	OPRD1 OPRM1	1.43e-04	4	92	2	IPR001418
Domain	Xpo1	IPO13 TNPO3	3.55e-04	6	92	2	PF08389
Domain	Exportin-1/Importin-b-like	IPO13 TNPO3	3.55e-04	6	92	2	IPR013598
Domain	PA2c	PLA2G3 PLA2G5	8.45e-04	9	92	2	SM00085
Domain	PLipase_A2	PLA2G3 PLA2G5	1.05e-03	10	92	2	IPR001211
Domain	PLipase_A2_His_AS	PLA2G3 PLA2G5	1.05e-03	10	92	2	IPR033113
Domain	PA2_HIS	PLA2G3 PLA2G5	1.28e-03	11	92	2	PS00118
Domain	PA2_ASP	PLA2G3 PLA2G5	1.28e-03	11	92	2	PS00119
Domain	PLipase_A2_dom	PLA2G3 PLA2G5	1.53e-03	12	92	2	IPR016090
Domain	-	PLA2G3 PLA2G5	1.53e-03	12	92	2	1.20.90.10
Domain	GPCR_Rhodpsn_7TM	VN1R4 NPBWR1 HTR1A P2RY8 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1 OR7A17	1.69e-03	670	92	10	IPR017452
Domain	G_PROTEIN_RECEP_F1_1	VN1R4 NPBWR1 HTR1A P2RY8 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1 OR7A17	1.98e-03	685	92	10	PS00237
Domain	Dynein_heavy_chain_D4_dom	DNAH2 DNAH1	2.10e-03	14	92	2	IPR024317
Domain	Dynein_HC_stalk	DNAH2 DNAH1	2.10e-03	14	92	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH2 DNAH1	2.10e-03	14	92	2	IPR013602
Domain	DHC_N2	DNAH2 DNAH1	2.10e-03	14	92	2	PF08393
Domain	MT	DNAH2 DNAH1	2.10e-03	14	92	2	PF12777
Domain	AAA_8	DNAH2 DNAH1	2.10e-03	14	92	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH2 DNAH1	2.10e-03	14	92	2	IPR011704
Domain	AAA_5	DNAH2 DNAH1	2.10e-03	14	92	2	PF07728
Domain	G_PROTEIN_RECEP_F1_2	VN1R4 NPBWR1 HTR1A P2RY8 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1 OR7A17	2.11e-03	691	92	10	PS50262
Domain	GPCR_Rhodpsn	VN1R4 NPBWR1 HTR1A P2RY8 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1 OR7A17	2.14e-03	692	92	10	IPR000276
Domain	DHC_fam	DNAH2 DNAH1	2.42e-03	15	92	2	IPR026983
Domain	Dynein_heavy_dom	DNAH2 DNAH1	2.42e-03	15	92	2	IPR004273
Domain	Dynein_heavy	DNAH2 DNAH1	2.42e-03	15	92	2	PF03028
Domain	LRR_6	NLRP11 FBXL14 NLRP4	2.52e-03	55	92	3	PF13516
Domain	-	RTTN IPO13 CTNND2 GCN1 TNPO3	4.83e-03	222	92	5	1.25.10.10
Domain	DAPIN	NLRP11 NLRP4	5.20e-03	22	92	2	PS50824
Domain	PYRIN	NLRP11 NLRP4	5.20e-03	22	92	2	PF02758
Domain	DAPIN	NLRP11 NLRP4	5.20e-03	22	92	2	IPR004020
Domain	PYRIN	NLRP11 NLRP4	5.20e-03	22	92	2	SM01289
Domain	NACHT	NLRP11 NLRP4	5.68e-03	23	92	2	PS50837
Domain	NACHT_NTPase	NLRP11 NLRP4	5.68e-03	23	92	2	IPR007111
Domain	7tm_1	NPBWR1 HTR1A P2RY8 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1 OR7A17	6.12e-03	677	92	9	PF00001
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	HTR1A TMIGD3 BDKRB2 OPRD1 OPRM1 HRH1 OR7A17	2.77e-05	186	67	7	MM15994
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPBWR1 HTR1A BDKRB2 OPRD1 OPRM1 LPAR6 HRH1 OR7A17	3.06e-05	260	67	8	M39397
Pathway	WP_GPCRS_NONODORANT	NPBWR1 HTR1A TMIGD3 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1	3.60e-05	266	67	8	MM15843
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	NPBWR1 HTR1A P2RY8 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1	4.22e-05	272	67	8	M13380
Pathway	WP_GPCRS_OTHER	HTR1A TMIGD3 OPRM1 OR1E3 OR7A17	9.12e-05	96	67	5	MM15939
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPBWR1 HTR1A TMIGD3 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1	1.73e-04	333	67	8	MM14963
Pathway	REACTOME_ACYL_CHAIN_REMODELLING_OF_PC	PLA2G3 LPCAT3 PLA2G5	2.77e-04	27	67	3	M643
Pathway	REACTOME_ACYL_CHAIN_REMODELLING_OF_PE	PLA2G3 LPCAT3 PLA2G5	3.09e-04	28	67	3	MM14578
Pathway	REACTOME_ACYL_CHAIN_REMODELLING_OF_PC	PLA2G3 LPCAT3 PLA2G5	3.09e-04	28	67	3	MM14575
Pathway	REACTOME_ACYL_CHAIN_REMODELLING_OF_PE	PLA2G3 LPCAT3 PLA2G5	3.43e-04	29	67	3	M702
Pathway	KEGG_GLYCEROPHOSPHOLIPID_METABOLISM	PLA2G3 PTDSS2 LPCAT3 PLA2G5	4.86e-04	77	67	4	M9131
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPBWR1 HTR1A BDKRB2 OPRD1 OPRM1 LPAR6 HRH1	9.43e-04	330	67	7	M18334
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPBWR1 HTR1A TMIGD3 BDKRB2 OPRD1 OPRM1 LPAR6 HRH1	9.47e-04	430	67	8	MM15160
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	NPBWR1 HTR1A BDKRB2 OPRD1 OPRM1 LPAR6 HRH1	1.55e-06	200	97	7	18240029
Pubmed	Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.	OPRD1 OPRM1	7.70e-06	2	97	2	19524516
Pubmed	Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.	OPRD1 OPRM1	7.70e-06	2	97	2	35674691
Pubmed	Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents.	OPRD1 OPRM1	7.70e-06	2	97	2	31815916
Pubmed	Involvement of delta and mu opioid receptors in the acute and sensitized locomotor action of cocaine in mice.	OPRD1 OPRM1	7.70e-06	2	97	2	23965295
Pubmed	Acute in utero morphine exposure slows G2/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse.	OPRD1 OPRM1	7.70e-06	2	97	2	18783375
Pubmed	Differential effect of membrane cholesterol removal on mu- and delta-opioid receptors: a parallel comparison of acute and chronic signaling to adenylyl cyclase.	OPRD1 OPRM1	7.70e-06	2	97	2	19520863
Pubmed	Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis.	OPRD1 OPRM1	7.70e-06	2	97	2	29055075
Pubmed	A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.	OPRD1 OPRM1	7.70e-06	2	97	2	24623156
Pubmed	The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors.	OPRD1 OPRM1	7.70e-06	2	97	2	11076532
Pubmed	The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells.	OPRD1 OPRM1	7.70e-06	2	97	2	12851402
Pubmed	Delta opioid receptor expression correlates to skin ageing and melanin expression in Asian women.	OPRD1 OPRM1	7.70e-06	2	97	2	38922774
Pubmed	Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.	OPRD1 OPRM1	7.70e-06	2	97	2	23836900
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	7.70e-06	2	97	2	11687802
Pubmed	Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption.	OPRD1 OPRM1	7.70e-06	2	97	2	9194936
Pubmed	Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.	OPRD1 OPRM1	7.70e-06	2	97	2	22106286
Pubmed	Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism.	OPRD1 OPRM1	7.70e-06	2	97	2	23554887
Pubmed	In vitro and in vivo characterization of the bifunctional μ- and δ- opioid receptors ligand MCRT on mouse gastrointestinal motility.	OPRD1 OPRM1	7.70e-06	2	97	2	30738575
Pubmed	Contrasting effects of mu opioid receptor and delta opioid receptor deletion upon the behavioral and neurochemical effects of cocaine.	OPRD1 OPRM1	7.70e-06	2	97	2	15262338
Pubmed	Increased abundance of opioid receptor heteromers after chronic morphine administration.	OPRD1 OPRM1	7.70e-06	2	97	2	20647592
Pubmed	Activation of mu-opioid receptors are required for the conditioned enhancement of NK cell activity.	OPRD1 OPRM1	7.70e-06	2	97	2	8930374
Pubmed	Antisense oligodeoxynucleotides to mu- and delta-opioid receptor mRNA block the enhanced effects of opioids during intestinal inflammation.	OPRD1 OPRM1	7.70e-06	2	97	2	11779029
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	7.70e-06	2	97	2	34910522
Pubmed	Potentiation of dopamine D1-like receptor signaling by concomitant activation of δ- and μ-opioid receptors in mouse medial prefrontal cortex.	OPRD1 OPRM1	7.70e-06	2	97	2	23073238
Pubmed	Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.	OPRD1 OPRM1	7.70e-06	2	97	2	10835636
Pubmed	Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors.	OPRD1 OPRM1	7.70e-06	2	97	2	26671460
Pubmed	Mu and delta opioid receptors oppositely regulate motor impulsivity in the signaled nose poke task.	OPRD1 OPRM1	7.70e-06	2	97	2	19198656
Pubmed	Differential response to morphine of the oligomeric state of μ-opioid in the presence of δ-opioid receptors.	OPRD1 OPRM1	7.70e-06	2	97	2	21361347
Pubmed	Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward.	OPRD1 OPRM1	7.70e-06	2	97	2	17895918
Pubmed	μ- and δ-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice.	OPRD1 OPRM1	7.70e-06	2	97	2	22302826
Pubmed	delta-, but not mu-, opioid receptor stabilizes K(+) homeostasis by reducing Ca(2+) influx in the cortex during acute hypoxia.	OPRD1 OPRM1	7.70e-06	2	97	2	17373650
Pubmed	Differential effects of impaired mitochondrial energy production on the function of mu and delta opioid receptors in neuronal SK-N-SH cells.	OPRD1 OPRM1	7.70e-06	2	97	2	16808998
Pubmed	Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice.	OPRD1 OPRM1	7.70e-06	2	97	2	9733948
Pubmed	Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice.	OPRD1 OPRM1	7.70e-06	2	97	2	14622224
Pubmed	Opioid receptors control viral replication in the airways.	OPRD1 OPRM1	7.70e-06	2	97	2	23222260
Pubmed	Mu and delta opioid receptor knockout mice show increased colonic sensitivity.	OPRD1 OPRM1	7.70e-06	2	97	2	27748566
Pubmed	Co-expression of mu and delta opioid receptors as receptor-G protein fusions enhances both mu and delta signalling via distinct mechanisms.	OPRD1 OPRM1	7.70e-06	2	97	2	18182056
Pubmed	Expression of delta- and mu-opioid receptors in the ventricular and subventricular zones of the developing human neocortex.	OPRD1 OPRM1	7.70e-06	2	97	2	18455254
Pubmed	Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons.	OPRD1 OPRM1	7.70e-06	2	97	2	19357247
Pubmed	Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation.	OPRD1 OPRM1	7.70e-06	2	97	2	21220103
Pubmed	Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways.	OPRD1 OPRM1	7.70e-06	2	97	2	34638633
Pubmed	Heterodimerization of mu- and delta-opioid receptors occurs at the cell surface only and requires receptor-G protein interactions.	OPRD1 OPRM1	7.70e-06	2	97	2	15657030
Pubmed	Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.	OPRD1 OPRM1	7.70e-06	2	97	2	20615975
Pubmed	Dissociation of heterotrimeric g proteins in cells.	NPBWR1 HTR1A OPRD1 OPRM1 LPAR6 HRH1	1.15e-05	179	97	6	18577758
Pubmed	Association between human opioid receptor genes polymorphisms and pressure pain sensitivity in females*.	OPRD1 OPRM1	2.31e-05	3	97	2	19032295
Pubmed	The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice.	OPRD1 OPRM1	2.31e-05	3	97	2	15090050
Pubmed	Cortical opioid markers in schizophrenia and across postnatal development.	OPRD1 OPRM1	2.31e-05	3	97	2	21810780
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.31e-05	3	97	2	30801007
Pubmed	A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.	OPRD1 OPRM1	2.31e-05	3	97	2	34821218
Pubmed	STAT6 transcription factor binding sites with mismatches within the canonical 5'-TTC...GAA-3' motif involved in regulation of delta- and mu-opioid receptors.	OPRD1 OPRM1	2.31e-05	3	97	2	15584925
Pubmed	Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.	OPRD1 OPRM1	2.31e-05	3	97	2	10082819
Pubmed	Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice.	OPRD1 OPRM1	2.31e-05	3	97	2	24943644
Pubmed	Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.	OPRD1 OPRM1	2.31e-05	3	97	2	21917790
Pubmed	Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia.	OPRD1 OPRM1	2.31e-05	3	97	2	18338799
Pubmed	Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers.	OPRD1 OPRM1	2.31e-05	3	97	2	18537939
Pubmed	Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.	OPRD1 OPRM1	2.31e-05	3	97	2	12603260
Pubmed	Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice.	OPRD1 OPRM1	2.31e-05	3	97	2	17676326
Pubmed	Searching for evidence of genetic mediation of opioid withdrawal by opioid receptor gene polymorphisms.	OPRD1 OPRM1	2.31e-05	3	97	2	26692286
Pubmed	Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study.	OPRD1 OPRM1	2.31e-05	3	97	2	17374034
Pubmed	Direct measurements of in situ interactions of rat brain opioid receptors with the guanine nucleotide-binding protein Go.	OPRD1 OPRM1	2.31e-05	3	97	2	8393523
Pubmed	NADPH oxidase pathway is involved in aortic contraction induced by A3 adenosine receptor in mice.	CYBB TMIGD3	2.31e-05	3	97	2	21606175
Pubmed	Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages.	CYBB PLA2G5	2.31e-05	3	97	2	21262967
Pubmed	Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.	OPRD1 OPRM1	2.31e-05	3	97	2	19416973
Pubmed	Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.	OPRD1 OPRM1	2.31e-05	3	97	2	11504820
Pubmed	No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.	OPRD1 OPRM1	2.31e-05	3	97	2	15178356
Pubmed	Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.	OPRD1 OPRM1	2.31e-05	3	97	2	12431223
Pubmed	The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.	OPRD1 OPRM1	2.31e-05	3	97	2	28049031
Pubmed	Modelling the PKPD of oxycodone in experimental pain - Impact of opioid receptor polymorphisms.	OPRD1 OPRM1	2.31e-05	3	97	2	26946441
Pubmed	Nociception increases during opioid infusion in opioid receptor triple knock-out mice.	OPRD1 OPRM1	2.31e-05	3	97	2	17544222
Pubmed	Endogenous opioid receptor genes and alcohol dependence among Taiwanese Han.	OPRD1 OPRM1	2.31e-05	3	97	2	14745298
Pubmed	Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.	OPRD1 OPRM1	2.31e-05	3	97	2	32941853
Pubmed	Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.	OPRD1 OPRM1	2.31e-05	3	97	2	8114680
Pubmed	Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.	OPRD1 OPRM1	2.31e-05	3	97	2	22752269
Pubmed	Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.	OPRD1 OPRM1	2.31e-05	3	97	2	11032994
Pubmed	Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice.	OPRD1 OPRM1	2.31e-05	3	97	2	25855262
Pubmed	Opioid receptors: from binding sites to visible molecules in vivo.	OPRD1 OPRM1	2.31e-05	3	97	2	18718480
Pubmed	Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.	OPRD1 OPRM1	2.31e-05	3	97	2	24874714
Pubmed	Delta opioid receptors on nociceptive sensory neurons mediate peripheral endogenous analgesia in colitis.	OPRD1 OPRM1	2.31e-05	3	97	2	34991641
Pubmed	Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes.	HTR1A OPRM1	2.31e-05	3	97	2	28282362
Pubmed	Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.	OPRD1 OPRM1	2.31e-05	3	97	2	11826143
Pubmed	Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.	OPRD1 OPRM1	2.31e-05	3	97	2	18213616
Pubmed	Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site.	OPRD1 OPRM1	2.31e-05	3	97	2	33555255
Pubmed	Enhanced humoral response in kappa-opioid receptor knockout mice.	OPRD1 OPRM1	2.31e-05	3	97	2	12507774
Pubmed	Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock-out mice: effects of chronic morphine administration.	OPRD1 OPRM1	2.31e-05	3	97	2	14975676
Pubmed	Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.	OPRD1 OPRM1	2.31e-05	3	97	2	11069979
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	4.60e-05	4	97	2	18849963
Pubmed	Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.	OPRD1 OPRM1	4.60e-05	4	97	2	8941707
Pubmed	Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells.	OPRD1 OPRM1	4.60e-05	4	97	2	12413885
Pubmed	Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse.	OPRD1 OPRM1	4.60e-05	4	97	2	9502813
Pubmed	Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.	OPRD1 OPRM1	4.60e-05	4	97	2	28855588
Pubmed	Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment.	OPRD1 OPRM1	4.60e-05	4	97	2	18687376
Pubmed	Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons.	OPRD1 OPRM1	4.60e-05	4	97	2	34787079
Pubmed	μ-Opioid and 5-HT1A receptors heterodimerize and show signalling crosstalk via G protein and MAP-kinase pathways.	HTR1A OPRM1	4.60e-05	4	97	2	22560877
Pubmed	Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.	OPRD1 OPRM1	4.60e-05	4	97	2	16053916
Pubmed	Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.	OPRD1 OPRM1	4.60e-05	4	97	2	11430857
Pubmed	Group V secreted phospholipase A2 plays a protective role against aortic dissection.	PLA2G3 PLA2G5	4.60e-05	4	97	2	32482892
Pubmed	Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors.	OPRD1 OPRM1	4.60e-05	4	97	2	8738226
Pubmed	The opioid system in alcohol and drug dependence: family-based association study.	OPRD1 OPRM1	4.60e-05	4	97	2	17503481
Pubmed	A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.	OPRD1 OPRM1	4.60e-05	4	97	2	30249798
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	NLRP11 RBM15 DHX30 HERC1 SLC4A5 TNPO3	5.16e-05	234	97	6	36243803
Cytoband	19q13.43	NLRP11 NLRP4 ZNF548	8.52e-04	87	97	3	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ANKFY1 CTC1 DNAH2 PFAS OR1E3	8.64e-04	346	97	5	chr17p13
Cytoband	15q15.3	STRC STRCP1	1.28e-03	25	97	2	15q15.3
Cytoband	17p13.1	CTC1 DNAH2 PFAS	2.05e-03	118	97	3	17p13.1
GeneFamily	Opioid receptors	OPRD1 OPRM1	9.08e-05	4	71	2	245
GeneFamily	Dyneins, axonemal	DNAH2 DNAH1	1.99e-03	17	71	2	536
GeneFamily	Armadillo repeat containing\|Importins	IPO13 TNPO3	2.23e-03	18	71	2	596
GeneFamily	NLR family	NLRP11 NLRP4	4.30e-03	25	71	2	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP11 NLRP4	4.30e-03	25	71	2	994
GeneFamily	Solute carriers	SLC24A5 SLC17A2 SLC35B2 SLC13A2 SLC18A1 SLC4A5	4.54e-03	395	71	6	752
Coexpression	YOSHIMURA_MAPK8_TARGETS_UP	CYBB HTR1A DNAH2 SLC13A2 BDKRB2 OPRD1 OPRM1 DNAH1 ADH7 HOOK1 KCNC3 SCN7A OR1E3 PLA2G5 HSD11B2 CTNND2 CABIN1	4.32e-06	1281	97	17	M1884
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MAP3K12 BDKRB2 EXD3 CLIC5 SCN7A ANGPTL7	4.76e-06	200	96	6	24e13b6d9d2d8b29df1f02544ea9c50084d9e75c
ToppCell	Hippocampus-Macroglia-CSF_related-CHOROID_PLEXUS\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CLDN6 SLC18A1 PLA2G5 SLC4A5 WDR72	8.24e-06	127	96	5	25d0b28c9df2d10fbcdb0aca47b75bf5c7c9c430
ToppCell	Hippocampus-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CLDN6 SLC18A1 PLA2G5 SLC4A5 WDR72	8.24e-06	127	96	5	352d44233a93c926aeb7c5fad49965fd82b873ca
ToppCell	Hippocampus-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CLDN6 SLC18A1 PLA2G5 SLC4A5 WDR72	8.24e-06	127	96	5	ca77f85502dd66f3cb4b15cf80f755104ca1e6ff
ToppCell	Hippocampus-Macroglia-CSF_related-CHOROID_PLEXUS-Choroid_Plexus.Ttr_(Ttr)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CLDN6 SLC18A1 PLA2G5 SLC4A5 WDR72	8.24e-06	127	96	5	b27d5141e661a4c6924aa6d7c5b046f9ae49955d
ToppCell	facs-Lung-EPCAM-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBM15 PFAS ST7L BDKRB2 SLC18A1	2.67e-05	162	96	5	1f1b93394b1f27cbb76b369c19b9313609edd577
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SLC17A2 CLDN6 CLIC5 HOOK1 SLC4A5	2.91e-05	165	96	5	b9b6b7b8cd65ba6948a5dd8b715cc7092e0be637
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CLDN6 OPRD1 HOOK1 HSD11B2 CTNND2	4.90e-05	184	96	5	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	wk_08-11-Epithelial-Distal_epithelial-epi-tip_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PLA2G3 CLDN6 HOOK1 HSD11B2 CTNND2	5.29e-05	187	96	5	5f9696097741b6e2b7b410c15c6b5ed883ed5eb2
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CLDN6 HOOK1 HSD11B2 CTNND2 WDR72	5.29e-05	187	96	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	wk_08-11-Epithelial-Distal_epithelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PLA2G3 CLDN6 HOOK1 HSD11B2 CTNND2	5.29e-05	187	96	5	eefffc2c6f7fa708a96e6bf07c6ce4e6c2e90847
ToppCell	wk_15-18-Epithelial-Distal_epithelial-epi-tip_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PLA2G3 CLDN6 OPRD1 HSD11B2 CTNND2	5.43e-05	188	96	5	eefd2930833d216efbd72f67541bb2d9e7d47f3b
ToppCell	wk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PLA2G3 CLDN6 HOOK1 HSD11B2 CTNND2	5.56e-05	189	96	5	a6c62b456982067ad4d224a2efa3919969000693
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CLDN6 HOOK1 HSD11B2 CTNND2 ESPL1	5.56e-05	189	96	5	c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CLDN6 HOOK1 CTNND2 ESPL1 WDR72	5.85e-05	191	96	5	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	Basal_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	GPC1 NLGN4Y ADH7 SPOCK3 LPAR6	5.85e-05	191	96	5	a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CLDN6 HOOK1 CTNND2 ESPL1 WDR72	5.99e-05	192	96	5	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PLA2G3 CLDN6 HOOK1 HSD11B2 CTNND2	6.30e-05	194	96	5	413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CLDN6 HOOK1 HSD11B2 CTNND2 WDR72	6.45e-05	195	96	5	98dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CLDN6 HOOK1 HSD11B2 CTNND2 WDR72	6.45e-05	195	96	5	ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPC1 GLB1L3 ADH7 HOOK1 SPOCK3	6.77e-05	197	96	5	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPC1 GLB1L3 ADH7 HOOK1 SPOCK3	7.27e-05	200	96	5	0594ca7bc313b73e1dc800cf058f8f798b0284cb
Drug	niaprazine	HTR1A SLC18A1 HRH1	1.35e-06	6	94	3	CID000071919
Drug	N-cyclopropylmethylnorazidomorphine	OPRD1 OPRM1 HRH1	2.36e-06	7	94	3	CID005489191
Drug	AC1LBBLW	OPRD1 OPRM1 HRH1	3.76e-06	8	94	3	CID000579851
Drug	CYM51010	OPRD1 OPRM1	1.69e-05	2	94	2	ctd:C583602
Drug	5-methylmethadone	OPRD1 OPRM1	1.69e-05	2	94	2	CID006452481
Drug	Dimethylthiambutene	OPRD1 OPRM1	1.69e-05	2	94	2	DB01444
Drug	3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone	OPRD1 OPRM1	1.69e-05	2	94	2	ctd:C507635
Drug	1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane	OPRD1 OPRM1	1.69e-05	2	94	2	ctd:C507634
Drug	Oxymorphone	OPRD1 OPRM1	1.69e-05	2	94	2	DB01192
Drug	Hydrocodone	OPRD1 OPRM1	1.69e-05	2	94	2	DB00956
Drug	endomorphin 1	OPRD1 OPRM1	1.69e-05	2	94	2	ctd:C105293
Drug	P 7556	OPRD1 OPRM1	1.69e-05	2	94	2	CID000131855
Drug	P 7618	OPRD1 OPRM1	1.69e-05	2	94	2	CID000126194
Drug	methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate	OPRD1 OPRM1	1.69e-05	2	94	2	ctd:C587452
Drug	P 7548	OPRD1 OPRM1	1.69e-05	2	94	2	CID000127329
Drug	Diphenoxylate	OPRD1 OPRM1	1.69e-05	2	94	2	DB01081
Drug	N-cyclopropylmethyl-4-hydroxy-14-methoxymorphinan	OPRD1 OPRM1	1.69e-05	2	94	2	CID005486977
Drug	N-Cyclopropylmethyl-4,14-dimethoxymorphinan	OPRD1 OPRM1	1.69e-05	2	94	2	CID005486976
Drug	Liden	OPRD1 OPRM1	1.69e-05	2	94	2	CID000010072
Drug	TRK-820	OPRD1 OPRM1 HRH1	2.40e-05	14	94	3	CID006445230
Drug	spiradoline	HTR1A OPRD1 OPRM1 SCN7A	3.89e-05	46	94	4	CID000005620
Drug	5-methyltryptamine	HTR1A OPRD1 HRH1	4.44e-05	17	94	3	CID000015760
Drug	TRK 820	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:C111212
Drug	Oxycodone	OPRD1 OPRM1	5.05e-05	3	94	2	DB00497
Drug	Hydromorphone	OPRD1 OPRM1	5.05e-05	3	94	2	DB00327
Drug	Codeine	OPRD1 OPRM1	5.05e-05	3	94	2	DB00318
Drug	Carfentanil	OPRD1 OPRM1	5.05e-05	3	94	2	DB01535
Drug	Morphine	OPRD1 OPRM1	5.05e-05	3	94	2	DB00295
Drug	Hydrocodone	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:D006853
Drug	3-Methylfentanyl	OPRD1 OPRM1	5.05e-05	3	94	2	DB01571
Drug	Heroin	OPRD1 OPRM1	5.05e-05	3	94	2	DB01452
Drug	3-Methylthiofentanyl	OPRD1 OPRM1	5.05e-05	3	94	2	DB01439
Drug	morphine-7,8-oxide	OPRD1 OPRM1	5.05e-05	3	94	2	CID005491901
Drug	Levorphanol	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:D007981
Drug	Levallorphan	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:D007977
Drug	mitragynine pseudoindoxyl	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:C121049
Drug	Buprenorphine	OPRD1 OPRM1	5.05e-05	3	94	2	DB00921
Drug	Levorphanol	OPRD1 OPRM1	5.05e-05	3	94	2	DB00854
Drug	Remifentanil	OPRD1 OPRM1	5.05e-05	3	94	2	DB00899
Drug	Nalbuphine	OPRD1 OPRM1	5.05e-05	3	94	2	DB00844
Drug	Fentanyl	OPRD1 OPRM1	5.05e-05	3	94	2	DB00813
Drug	Cytochrophin-4	OPRD1 OPRM1	5.05e-05	3	94	2	CID000126809
Drug	Sufentanil	OPRD1 OPRM1	5.05e-05	3	94	2	DB00708
Drug	Enkephalin, Leucine	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:D004743
Drug	Propoxyphene	OPRD1 OPRM1	5.05e-05	3	94	2	DB00647
Drug	Butorphanol	OPRD1 OPRM1	5.05e-05	3	94	2	DB00611
Drug	Butorphanol	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:D002077
Drug	cyclorphan	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:C084603
Drug	Alvimopan	OPRD1 OPRM1	5.05e-05	3	94	2	DB06274
Drug	dextrallorphan	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:C044130
Drug	14-phenylpropoxymetopon	OPRD1 OPRM1	5.05e-05	3	94	2	ctd:C478565
Drug	CID5362039	OPRD1 OPRM1	5.05e-05	3	94	2	CID005362039
Drug	Amitriptyline	HTR1A OPRD1 HRH1	5.32e-05	18	94	3	DB00321
Drug	CFC-11	HTR1A BDKRB2 SMPD2 DMP1	6.34e-05	52	94	4	CID000006389
Drug	NSC76436	FBXL14 OPRD1 OPRM1	7.38e-05	20	94	3	CID000002828
Drug	AC1LDA7H	OPRD1 OPRM1 HRH1	9.91e-05	22	94	3	CID000614838
Drug	Dynorphins	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:D004399
Drug	Methadone	OPRD1 OPRM1	1.01e-04	4	94	2	DB00333
Drug	AC1L5BQM	OPRD1 OPRM1	1.01e-04	4	94	2	CID000174892
Drug	Diprenorphine	OPRD1 OPRM1	1.01e-04	4	94	2	DB01548
Drug	Dmt-NMe-Ala-Aba-Gly-NH2	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:C569763
Drug	3B-b	OPRD1 OPRM1	1.01e-04	4	94	2	CID000533975
Drug	phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:C049352
Drug	tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:C092721
Drug	Naltrexone	OPRD1 OPRM1	1.01e-04	4	94	2	DB00704
Drug	AC1OCQTX	OPRD1 OPRM1	1.01e-04	4	94	2	CID000824375
Drug	endomorphin 2	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:C105294
Drug	Methadyl Acetate	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:D008692
Drug	deltorphin II, Ala(2)-	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:C060209
Drug	YM114	HTR1A HRH1	1.01e-04	4	94	2	CID000132963
Drug	7-hydroxymitragynine	OPRD1 OPRM1	1.01e-04	4	94	2	ctd:C482678
Drug	SCH 23390	HTR1A FBXL14 OPRD1 OPRM1 HRH1	1.20e-04	116	94	5	CID000005018
Drug	desipramine	HTR1A OPRD1 OPRM1 SLC18A1 HRH1 SMPD2	1.30e-04	188	94	6	CID000002995
Drug	NSC186061	HTR1A BDKRB2 OPRD1 OPRM1 HRH1	1.30e-04	118	94	5	CID000004163
Drug	Gi-2	HTR1A COP1 OPRD1 OPRM1 HRH1 TBL1X	1.59e-04	195	94	6	CID011957432
Drug	estradiol, USP; Up 200; 0.1uM; HL60; HT_HG-U133A	ST7L HIPK3 SPOCK3 HRH1 CTNND2 DMP1	1.59e-04	195	94	6	2668_UP
Drug	Dihydromorphine	OPRD1 OPRM1	1.67e-04	5	94	2	DB01565
Drug	Naloxone	OPRD1 OPRM1	1.67e-04	5	94	2	DB01183
Drug	Ondansetron	HTR1A OPRM1	1.67e-04	5	94	2	DB00904
Drug	oxymorphamine	OPRD1 OPRM1	1.67e-04	5	94	2	CID000134844
Drug	Sc 39566	OPRD1 OPRM1	1.67e-04	5	94	2	CID000130018
Drug	Buspirone hydrochloride [33386-08-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	PTDSS2 MAP3K12 LPCAT3 ERI3 TMEM184C CABIN1	1.68e-04	197	94	6	5343_DN
Drug	Milrinone [78415-72-2]; Down 200; 19uM; MCF7; HT_HG-U133A	ANKFY1 PLA2G3 PTDSS2 LINS1 LPCAT3 CTNND2	1.83e-04	200	94	6	3552_DN
Drug	GBR 12909	HTR1A SLC18A1 SCN7A HRH1	1.92e-04	69	94	4	CID000003455
Drug	Magnesium	HTR1A OPRD1 OPRM1 HRH1	2.14e-04	71	94	4	ctd:D008274
Drug	5(G)-TASP	BDKRB2 OPRD1 OPRM1	2.30e-04	29	94	3	CID000488931
Drug	piperazine	HTR1A OPRD1 KCNC3 HRH1	2.38e-04	73	94	4	CID000004837
Drug	Etorphine	OPRD1 OPRM1	2.50e-04	6	94	2	DB01497
Drug	Npys-cysteine	OPRD1 OPRM1	2.50e-04	6	94	2	CID000133220
Drug	AC1L2OET	OPRD1 OPRM1	2.50e-04	6	94	2	CID000125331
Drug	NSC612111	OPRD1 OPRM1	2.50e-04	6	94	2	CID000163346
Drug	Loperamide	OPRD1 OPRM1	2.50e-04	6	94	2	DB00836
Drug	RX8008M	OPRD1 OPRM1	2.50e-04	6	94	2	CID000162443
Drug	8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine	HTR1A HRH1	2.50e-04	6	94	2	ctd:C434584
Drug	dl-Bremazocine	NPBWR1 OPRD1 OPRM1	2.82e-04	31	94	3	CID000001223
Drug	paliperidone	HTR1A HRH1 HSD11B2	2.82e-04	31	94	3	CID000115237
Drug	AC1N8H7N	FBXL14 OPRD1 OPRM1 TNPO3	3.08e-04	78	94	4	CID004318740
Drug	Guanosine Triphosphate	HTR1A OPRM1 HRH1	3.40e-04	33	94	3	ctd:D006160
Drug	Chlorpromazine	HTR1A HRH1	3.49e-04	7	94	2	DB00477
Drug	Tyr-ala-phe-gly	OPRD1 OPRM1	3.49e-04	7	94	2	CID005487532
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	9.62e-06	2	92	2	DOID:0110471 (implicated_via_orthology)
Disease	Parkinson's disease (implicated_via_orthology)	NPBWR1 HTR1A OPRD1 OPRM1 HIPK3 ADH7	1.01e-05	157	92	6	DOID:14330 (implicated_via_orthology)
Disease	Hypotension, Orthostatic	OPRD1 OPRM1	2.88e-05	3	92	2	C0020651
Disease	anxiety disorder (is_implicated_in)	HTR1A CTNND2	1.43e-04	6	92	2	DOID:2030 (is_implicated_in)
Disease	Depression, Postpartum	HTR1A OPRM1	2.00e-04	7	92	2	C0221074
Disease	Pruritus	OPRM1 HRH1	2.66e-04	8	92	2	C0033774
Disease	Pain, Migratory	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0751407
Disease	Suffering, Physical	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0751408
Disease	Pain, Crushing	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0458259
Disease	Pain, Splitting	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0458257
Disease	Pain	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0030193
Disease	Radiating pain	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0234254
Disease	Pain, Burning	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0234230
Disease	Ache	HTR1A BDKRB2 HRH1	4.87e-04	49	92	3	C0234238
Disease	Psychoses, Substance-Induced	HTR1A OPRM1	1.27e-03	17	92	2	C0033941
Disease	Psychoses, Drug	HTR1A OPRM1	1.94e-03	21	92	2	C0033937
Disease	eye color	SLC24A5 TTC3 HOOK1	2.83e-03	90	92	3	EFO_0003949

Protein segments in the cluster

Peptide	Gene	Start	Entry
PWAMGEVLLFRCKLG	TMEM184C	161	Q9NVA4
DPMLLFTGRTWKGCV	ADH7	316	P40394
CWSVDFNLMDPKLLA	COP1	516	Q8NHY2
IFVTCGDWDLKVMLP	ERI3	241	O43414
TAKCMLGLLLGKIWP	DCUN1D4	216	Q92564
IWGCTLLLSSPMLVF	BDKRB2	181	P30411
TAWMLCKLLDKAGVP	ALDH8A1	186	Q9H2A2
TVMKLPWDSLLTRCL	EIF2D	451	P41214
PKWASLNLGVLMCIE	AGAP11	351	Q8TF27
TLCEPLVASLWMKLG	CTC1	906	Q2NKJ3
LKFCLVGWGIPAIMV	ADGRG4	2851	Q8IZF6
PLMGVCFVLEKWDLS	EFL1	886	Q7Z2Z2
SLAMCIVGRLPWVKL	AQP10	86	Q96PS8
LLMDTFSCELLPWGV	HSD11B2	241	P80365
KLSTLTLLWPCPMTF	DHX30	276	Q7L2E3
TLLWPCPMTFVAKGR	DHX30	281	Q7L2E3
SDCMPRWKVAILIPF	B4GALT5	156	O43286
CPFSQRLFMILWLKG	CLIC5	191	Q9NZA1
LWNLSSCDALKMPII	CTNND2	661	Q9UQB3
GTPGTVLDWCFKLKL	DDX25	221	Q9UHL0
SPKLCLAWQGMLLLK	RBM15	781	Q96T37
FCLSRGLALKMSPWA	RFNG	206	Q9Y644
GIITCFDVLKWTMLP	P2RY8	171	Q86VZ1
MLKKPLSAVTWLCIF	ANGPTL7	1	O43827
LFRLLDMLSKEPPWC	ANKFY1	1091	Q9P2R3
LMGTWPFGTILCKIV	OPRM1	131	P35372
MLGSPCLLWLLAVTF	LRRN4CL	1	Q8ND94
LFLKPSCMLEVITWP	LINS1	276	Q8NG48
ALWMLPSLCKFSLAA	IL31RA	6	Q8NI17
SLLKRKMAPGCWFLI	NLRP11	261	P59045
DFWISLPGTLCSEKM	GPC1	391	P35052
LLSPCLSWKRMAGIF	GLB1L3	6	Q8NCI6
LGCSKEPARSLWISM	HERC1	1226	Q15751
SMQGSPPLFLCLLWK	MED23	781	Q9ULK4
WTMPHCVLTLKLIGL	LPCAT3	141	Q6P1A2
KGMGESCFEDLLPWL	GCN1	1686	Q92616
NWPFGDLLCKISVML	LPAR6	81	P43657
PLLCWILCTSLKQEM	NLRP4	341	Q96MN2
LLMFLWGLSCALPVT	DMP1	6	Q13316
PCLKVLNLGLWQMTD	FBXL14	381	Q8N1E6
ILGLPFCEAIDMWSL	HIPK3	371	Q9H422
METWPFGELLCKAVL	OPRD1	111	P41143
MKGLLPLAWFLACSV	PLA2G5	1	P39877
PLMCVLKEAWTELGL	SMPD2	301	O60906
GLLWLPLLFTSVCVM	NLGN4Y	6	Q8NFZ3
SILGLMPFIECWLRK	DNAH1	2011	Q9P2D7
KSVLGCWKGLLLPSS	ESPL1	1796	Q14674
MCTKTIPVLWGCFLL	BPIFC	1	Q8NFQ6
GPVWAALLLFLLMCE	C1QTNF6	26	Q9BXI9
PFFTWKCLGESLLAM	CABIN1	266	Q9Y6J0
KFLWCLCLLSVMSLP	GUCY2F	31	P51841
IKLCTGWMVTSLPLY	DPY19L4	591	Q7Z388
TLGIIMGTFILCWLP	HTR1A	346	P08908
LFGCLRPVWTMIGKA	MAP3K12	91	Q12852
KWIVGPMFLYLCERL	CYBB	271	P04839
LYLLMSKWSLGRPLC	HRH1	86	P35367
KLPLCDSLMIWLQTF	HOOK1	11	Q9UJC3
CHLSLSWMPNLDKLV	DNAH2	3896	Q9P225
AIILMALFWCTEALP	SLC13A2	41	Q13183
LMWTCSFLLPGLQTE	DSCR10	16	P59022
CFSLLSMWIKEALQP	IPO13	896	O94829
DFLLRQWPFGELMCK	NPBWR1	96	P48145
MSPKCCLGLLTLSWL	OR1E3	136	Q8WZA6
MAWTPLLLLFLSHCT	IGLV5-48	1	A0A075B6I7
AMGIWKELFCELSPL	PLEKHM1	546	Q9Y4G2
CLALKPVSDMLRIAW	RTTN	1011	Q86VV8
MLEESPFLKCTLPWG	RSBN1L	486	Q6PCB5
ALPSVSWMLLSCLML	REG3A	6	Q06141
MAWTPLLLLFLSHCT	IGLV5-45	1	A0A087WSX0
LGIYCGMKTLEWLSL	PTDSS2	256	Q9BVG9
LMVLWLSFCTDLEIP	OR7A17	161	O14581
MLWELLGTTCFKLAP	PLA2G3	416	Q9NZ20
ISKMELLACFSPVLW	STRC	701	Q7RTU9
GLVSCALPMWKVTAF	CLDN6	21	P56747
TEGVLMRDPKFLWCA	RNF31	786	Q96EP0
NAIKWDPSGMLLASC	TBL1X	416	O60907
CTMGLVLPLWSDTLI	SSH2	136	Q76I76
AETTPMWQALKLLFC	SLC35B2	101	Q8TB61
ETKKLMWLFGCPLLL	PFAS	56	O15067
IKAMVTCLPLWAIFL	SLC17A2	266	O00624
KLFLSCLLPWGVDKD	WDR72	796	Q3MJ13
LTKLGSIDNCWPMLS	TTC3	181	P53804
MLCLGIPWFIKTAFI	SLC24A5	411	Q71RS6
LTPFWERCKLFLMPA	SLC4A5	986	Q9BY07
IMGIFAKAVLGLWCP	ST7L	536	Q8TDW4
FPDVLCLGLMLWVSS	VN1R4	186	Q7Z5H5
LPICKDSLGWMFNRL	SPOCK3	246	Q9BQ16
AIADLALQMPSWKGC	TNPO3	111	Q9Y5L0
MEGWKDLPATSCLLQ	ZNF548	156	Q8NEK5
PLMAAKVCIGSLRWL	TTC7A	451	Q9ULT0
DCVFMSLTNLPKWRP	SCN7A	131	Q01118
ISKMELLACFSPVLW	STRCP1	701	A6NGW2
ILSFQLKVCFLPVMW	TMIGD3	46	P0DMS9
FTIWNKSLMILSGLP	MID2	691	Q9UJV3
TMHLFKLKDSWCFLP	TMEM267	131	Q0VDI3
MCSPKWQLGLAFLPA	SLC18A1	331	P54219
PKTWSGMLVGALCAL	KCNC3	511	Q14003
LVLMDSWCQPGFDIK	EXD3	201	Q8N9H8