Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium channel activity

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

7.50e-07129275GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.63e-06151275GO:0015085
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.37e-06343276GO:0005261
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPM4 TRPM8 TRPM2

9.66e-0631273GO:0099604
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

2.80e-05459276GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

3.02e-05465276GO:0046873
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

KCNN3 TRPM4 TRPM8 TRPM2

3.58e-05140274GO:0099094
GeneOntologyMolecularFunctionchannel activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.94e-05525276GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

6.00e-05526276GO:0022803
GeneOntologyMolecularFunctionstore-operated calcium channel activity

TRPC7 TRPC6

1.15e-0412272GO:0015279
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

KCNN3 TRPM4 TRPM8 TRPM2

1.25e-04193274GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

KCNN3 TRPM4 TRPM8 TRPM2

1.35e-04197274GO:0022834
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.58e-04627276GO:0022890
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC7 TRPC6

1.59e-0414272GO:0070679
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

2.15e-04664276GO:0008324
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

4.38e-04758276GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.57e-04793276GO:0015075
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

KCNN3 TRPM4

6.05e-0427272GO:0005227
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

KCNN3 TRPM4

7.99e-0431272GO:0022839
GeneOntologyMolecularFunctiongated channel activity

KCNN3 TRPM4 TRPM8 TRPM2

9.95e-04334274GO:0022836
GeneOntologyMolecularFunctionsodium channel activity

TRPM4 TRPM2

2.24e-0352272GO:0005272
GeneOntologyMolecularFunctiontransmembrane transporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

4.26e-031180276GO:0022857
GeneOntologyMolecularFunctiontransporter activity

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

6.55e-031289276GO:0005215
GeneOntologyMolecularFunctionalcohol binding

TRPC7 TRPC6

8.35e-03102272GO:0043178
GeneOntologyBiologicalProcesspositive regulation of DNA endoreduplication

E2F7 E2F8

1.78e-062282GO:0032877
GeneOntologyBiologicalProcessregulation of cardiac conduction

ACE2 TRPM4 CORIN

7.99e-0629283GO:1903779
GeneOntologyBiologicalProcessregulation of DNA endoreduplication

E2F7 E2F8

1.06e-054282GO:0032875
GeneOntologyBiologicalProcessDNA endoreduplication

E2F7 E2F8

1.77e-055282GO:0042023
GeneOntologyBiologicalProcessnegative regulation of cytokinesis

E2F7 E2F8

3.72e-057282GO:0032466
GeneOntologyBiologicalProcesschorionic trophoblast cell differentiation

E2F7 E2F8

3.72e-057282GO:0060718
GeneOntologyBiologicalProcesschorion development

E2F7 E2F8

9.70e-0511282GO:0060717
GeneOntologyBiologicalProcessextraembryonic membrane development

E2F7 E2F8

1.60e-0414282GO:1903867
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.66e-04392285GO:0070588
GeneOntologyBiologicalProcesspositive regulation of DNA-templated DNA replication

E2F7 E2F8

1.85e-0415282GO:2000105
GeneOntologyBiologicalProcesshepatocyte differentiation

E2F7 E2F8

2.11e-0416282GO:0070365
GeneOntologyBiologicalProcessnegative regulation of cell division

E2F7 E2F8

2.39e-0417282GO:0051782
GeneOntologyBiologicalProcesstrophoblast giant cell differentiation

E2F7 E2F8

3.00e-0419282GO:0060707
GeneOntologyBiologicalProcesscardiac conduction

ACE2 TRPM4 CORIN

3.32e-04100283GO:0061337
GeneOntologyBiologicalProcesscellular response to nitrogen compound

GHR IFIH1 TRPM4 TAAR1 HMGCS2 TRPM2

4.36e-04752286GO:1901699
GeneOntologyBiologicalProcesscalcium ion transport

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.51e-04509285GO:0006816
GeneOntologyBiologicalProcessprotein complex oligomerization

IFIH1 TRPM4 NLRC4 TRPM2

6.48e-04296284GO:0051259
GeneOntologyBiologicalProcessdendritic cell chemotaxis

TRPM4 TRPM2

7.05e-0429282GO:0002407
GeneOntologyBiologicalProcesscell differentiation involved in embryonic placenta development

E2F7 E2F8

9.71e-0434282GO:0060706
GeneOntologyBiologicalProcessdendritic cell migration

TRPM4 TRPM2

1.09e-0336282GO:0036336
GeneOntologyBiologicalProcesscellular response to organic cyclic compound

IFIH1 TRPM4 TAAR1 HMGCS2 TRPM2

1.20e-03605285GO:0071407
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.27e-03922286GO:0098662
GeneOntologyBiologicalProcessintracellular calcium ion homeostasis

TRPM8 TRPC7 TRPC6 TRPM2

1.33e-03359284GO:0006874
GeneOntologyBiologicalProcessinorganic ion homeostasis

CORIN TRPM8 TRPC7 TRPC6 TRPM2

1.36e-03622285GO:0098771
GeneOntologyBiologicalProcesspeptide hormone processing

ACE2 CORIN

1.41e-0341282GO:0016486
GeneOntologyBiologicalProcessresponse to growth hormone

GHR HMGCS2

1.41e-0341282GO:0060416
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.42e-03942286GO:0098655
GeneOntologyBiologicalProcessresponse to purine-containing compound

TRPM4 HMGCS2 TRPM2

1.45e-03166283GO:0014074
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

GHR GALNTL6 IFIH1 TRPM4 ZDHHC6 TRPC6

1.70e-03976286GO:0018193
GeneOntologyBiologicalProcesssignaling receptor ligand precursor processing

ACE2 CORIN

1.77e-0346282GO:0140448
GeneOntologyBiologicalProcesscalcium ion homeostasis

TRPM8 TRPC7 TRPC6 TRPM2

1.78e-03389284GO:0055074
GeneOntologyBiologicalProcessmetal ion transport

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.92e-031000286GO:0030001
GeneOntologyBiologicalProcesspositive regulation of heart contraction

ACE2 TRPM4

2.01e-0349282GO:0045823
GeneOntologyBiologicalProcessregulation of hormone levels

GHR ACE2 TRPM4 CORIN TRPM2

2.06e-03684285GO:0010817
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

KCNN3 TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

2.10e-031017286GO:0098660
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by hormone

ACE2 CORIN

2.17e-0351282GO:0001990
GeneOntologyBiologicalProcesscell cycle DNA replication

E2F7 E2F8

2.17e-0351282GO:0044786
GeneOntologyBiologicalProcessregulation of DNA-templated DNA replication

E2F7 E2F8

2.35e-0353282GO:0090329
GeneOntologyBiologicalProcesspositive regulation of blood circulation

ACE2 TRPM4

2.35e-0353282GO:1903524
GeneOntologyBiologicalProcessmonoatomic cation homeostasis

CORIN TRPM8 TRPC7 TRPC6 TRPM2

2.35e-03705285GO:0055080
GeneOntologyBiologicalProcessdendritic cell differentiation

TMEM176B TRPM2

2.43e-0354282GO:0097028
GeneOntologyBiologicalProcessresponse to organic cyclic compound

GHR IFIH1 TRPM4 TAAR1 HMGCS2 TRPM2

2.44e-031048286GO:0014070
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CORIN TRPM8 TRPC7 TRPC6 TRPM2

2.53e-03717285GO:0050801
GeneOntologyBiologicalProcessliver development

E2F7 HMGCS2 E2F8

2.53e-03202283GO:0001889
GeneOntologyBiologicalProcesshepaticobiliary system development

E2F7 HMGCS2 E2F8

2.64e-03205283GO:0061008
GeneOntologyBiologicalProcessresponse to temperature stimulus

TRPM8 HMGCS2 TRPM2

2.75e-03208283GO:0009266
GeneOntologyBiologicalProcesspositive regulation of DNA replication

E2F7 E2F8

2.80e-0358282GO:0045740
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure mediated by a chemical signal

ACE2 CORIN

3.10e-0361282GO:0003044
DomainTRPC_channel

TRPC7 TRPC6 TRPM2

1.05e-077283IPR002153
DomainIon_trans_dom

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

6.81e-07114285IPR005821
DomainIon_trans

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

6.81e-07114285PF00520
DomainTRP_dom

TRPC7 TRPC6

3.24e-056282IPR013555
DomainTRP_2

TRPC7 TRPC6

3.24e-056282PF08344
DomainE2F

E2F7 E2F8

6.03e-058282IPR015633
DomainTRP_channel

TRPC7 TRPC6

1.18e-0411282IPR004729
DomainE2F_TDP

E2F7 E2F8

1.18e-0411282PF02319
DomainE2F_TDP

E2F7 E2F8

1.18e-0411282SM01372
DomainE2F_WHTH_DNA-bd_dom

E2F7 E2F8

1.18e-0411282IPR003316
DomainCARD

IFIH1 NLRC4

8.00e-0428282PF00619
DomainCARD

IFIH1 NLRC4

9.81e-0431282IPR001315
DomainCARD

IFIH1 NLRC4

1.11e-0333282PS50209
DomainAnkyrin_rpt

TRPM4 TRPC7 TRPC6

6.90e-03262283IPR002110
DomainSH3_2

DOCK3 ZDHHC6

7.33e-0386282IPR011511
DomainSH3_2

DOCK3 ZDHHC6

7.33e-0386282PF07653
Domain-

IFIH1 NLRC4

8.52e-03932821.10.533.10
DomainDEATH-like_dom

IFIH1 NLRC4

9.61e-0399282IPR011029
PathwayREACTOME_TRP_CHANNELS

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.45e-1028225MM14943
PathwayREACTOME_TRP_CHANNELS

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.45e-1028225M27241
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

3.70e-0799225MM14910
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.20e-07106225M27200
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

6.35e-06176225MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

7.68e-06183225M997
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST

E2F7 E2F8

8.31e-059222MM15337
PathwayREACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING

TRPC7 TRPC6

1.04e-0410222M27330
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

TRPC7 TRPC6

1.79e-0413222MM14553
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST

E2F7 E2F8

2.09e-0414222M27635
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

TRPC7 TRPC6

2.75e-0416222M26945
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

TRPC7 TRPC6

6.82e-0425222MM14511
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

TRPC7 TRPC6

7.97e-0427222M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

TRPC7 TRPC6

7.97e-0427222MM15053
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

TRPC7 TRPC6

8.57e-0428222M924
PathwayWP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY

IFIH1 ACE2

1.05e-0331222M39897
PathwayWP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION

IFIH1 ACE2

1.05e-0331222M39859
PathwayWP_MITOCHONDRIAL_IMMUNE_RESPONSE_TO_SARSCOV2

IFIH1 ACE2

1.19e-0333222M40066
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

E2F7 E2F8

1.27e-0334222MM15325
PathwayREACTOME_NETRIN_1_SIGNALING

TRPC7 TRPC6

2.11e-0344222M875
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

E2F7 E2F8

2.62e-0349222M27614
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

3.44e-03681225MM14985
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

9.75e-122428533884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.22e-112528516382100
Pubmed

An introduction to TRP channels.

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.85e-112728516460286
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

5.42e-113328519834762
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

2.46e-104428519322198
Pubmed

Subunit composition of mammalian transient receptor potential channels in living cells.

TRPC7 TRPC6 TRPM2

2.61e-08828312032305
Pubmed

Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.

TRPC7 TRPC6 TRPM2

3.91e-08928311290752
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM4 TRPM8 TRPM2

1.02e-071228319850157
Pubmed

The transmembrane segment S6 determines cation versus anion selectivity of TRPM2 and TRPM8.

TRPM8 TRPM2

6.25e-07228217604279
Pubmed

Atypical E2Fs inhibit tumor angiogenesis.

E2F7 E2F8

6.25e-07228228925392
Pubmed

E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7.

E2F7 E2F8

6.25e-07228215897886
Pubmed

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer.

E2F7 E2F8

6.25e-07228227452520
Pubmed

Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2.

TRPM8 TRPM2

6.25e-07228223185472
Pubmed

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.

E2F7 E2F8

6.25e-07228222180533
Pubmed

Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.

TRPC6 TRPM2

6.25e-07228212564954
Pubmed

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice.

E2F7 E2F8

6.25e-07228232259305
Pubmed

DNA-damage response control of E2F7 and E2F8.

E2F7 E2F8

6.25e-07228218202719
Pubmed

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.

TRPC7 TRPC6

6.25e-07228223529130
Pubmed

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B.

TRPC7 TRPM2

6.25e-07228231755176
Pubmed

Contribution of the S5-pore-S6 domain to the gating characteristics of the cation channels TRPM2 and TRPM8.

TRPM8 TRPM2

6.25e-07228220587417
Pubmed

PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.

TRPC7 TRPC6

6.25e-07228224470487
Pubmed

Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression.

E2F7 E2F8

1.87e-06328231475738
Pubmed

Atypical E2f functions are critical for pancreas polyploidization.

E2F7 E2F8

1.87e-06328229329320
Pubmed

Selective association of TRPC channel subunits in rat brain synaptosomes.

TRPC6 TRPM2

1.87e-06328212377790
Pubmed

Inhibition of polyploidization in Pten-deficient livers reduces steatosis.

E2F7 E2F8

1.87e-06328235924448
Pubmed

Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice.

GHR ACE2

1.87e-06328222947377
Pubmed

The Retinal Basis of Light Aversion in Neonatal Mice.

TRPC7 TRPC6

1.87e-06328235396331
Pubmed

Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.

TRPC7 TRPC6

1.87e-06328228526717
Pubmed

Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse.

TRPM4 TRPM8

3.75e-06428223410158
Pubmed

E2F8 is essential for polyploidization in mammalian cells.

E2F7 E2F8

3.75e-06428223064264
Pubmed

Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.

TRPC7 TRPC6

3.75e-06428230017393
Pubmed

E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.

E2F7 E2F8

3.75e-06428222903062
Pubmed

Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.

E2F7 E2F8

3.75e-06428222422820
Pubmed

2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.

TRPM8 TRPC6

6.24e-06528215194687
Pubmed

Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.

TRPC6 TRPM2

6.24e-06528216857711
Pubmed

Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients.

E2F7 E2F8

6.24e-06528223744542
Pubmed

Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior.

TRPM8 TRPM2

6.24e-06528230842533
Pubmed

TRPC channels are necessary mediators of pathologic cardiac hypertrophy.

TRPC7 TRPC6

6.24e-06528220351294
Pubmed

Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.

TRPC7 TRPC6

6.24e-06528221261756
Pubmed

Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury.

E2F7 E2F8

6.24e-06528230928253
Pubmed

The Sensory Coding of Warm Perception.

TRPM8 TRPM2

6.24e-06528232208171
Pubmed

TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.

TRPM4 TRPC6

9.36e-06628232414784
Pubmed

MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.

TRPC7 TRPC6

1.31e-05728215757897
Pubmed

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.

TRPC7 TRPC6

1.31e-05728238835669
Pubmed

Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.

TRPC7 TRPC6

1.31e-05728238109525
Pubmed

RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.

TRPC7 TRPC6

1.31e-05728232350291
Pubmed

TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.

TRPC7 TRPC6

1.31e-05728236592529
Pubmed

Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.

TRPC7 TRPC6

1.31e-05728215336983
Pubmed

Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.

TRPC7 TRPC6

1.31e-05728236257322
Pubmed

Canonical and atypical E2Fs regulate the mammalian endocycle.

E2F7 E2F8

1.74e-05828223064266
Pubmed

Association of immunophilins with mammalian TRPC channels.

TRPC7 TRPC6

1.74e-05828215199065
Pubmed

Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.

TRPC7 TRPC6

1.74e-05828225471572
Pubmed

Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.

TRPC7 TRPC6

2.24e-05928217480026
Pubmed

Heterogeneous distribution of TRPC proteins in the embryonic cortex.

TRPC7 TRPC6

2.80e-051028218989690
Pubmed

Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.

E2F7 E2F8

2.80e-051028218194653
Pubmed

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.

TRPC7 TRPC6

2.80e-051028227177420
Pubmed

Rb is critical in a mammalian tissue stem cell population.

E2F7 E2F8

2.80e-051028217210791
Pubmed

Melanopsin signalling in mammalian iris and retina.

TRPC7 TRPC6

4.85e-051328222051675
Pubmed

Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.

TRPC7 TRPC6

8.44e-051728222411552
Pubmed

Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.

TRPM8 TRPM2

9.49e-051828231911949
Pubmed

Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

WDR64 OPN3

1.18e-042028219626040
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

TRPC7 TRPC6

1.30e-042128230270038
Pubmed

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

IFIH1 NLRC4

1.56e-042328229576451
Pubmed

Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle.

E2F7 E2F8

2.50e-042928234246625
Pubmed

A genome-wide association study of behavioral disinhibition.

TRPM8 WDR64

2.68e-043028223942779
Pubmed

Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress.

TRPM8 TRPM2

3.25e-043328230037926
Pubmed

Atypical E2F repressors and activators coordinate placental development.

E2F7 E2F8

3.25e-043328222516201
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

TRPC7 TRPC6

4.32e-043828230786075
InteractionTRPM4 interactions

ACE2 TRPM4 TRPM8

2.29e-0540283int:TRPM4
InteractionTRPC7 interactions

TRPC7 TRPC6

2.78e-056282int:TRPC7
Cytoband1q43

WDR64 OPN3

4.49e-04512821q43
CytobandEnsembl 112 genes in cytogenetic band chr1q43

WDR64 OPN3

6.63e-0462282chr1q43
GeneFamilyTransient receptor potential cation channels

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.22e-1028215249
GeneFamilyE2F transcription factors

E2F7 E2F8

3.58e-058212982
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

IFIH1 NLRC4

5.48e-0430212959
CoexpressionSMID_BREAST_CANCER_ERBB2_UP

ACE2 TRPM4 HMGCS2 TSPAN1

2.00e-05152284M3102
ToppCellLPS_only-Unknown|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

E2F7 ACE2 HMGCS2 TRPC6

7.91e-071152847a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCellLPS_only-Unknown-Endothelial-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

E2F7 ACE2 HMGCS2 TRPC6

7.91e-07115284c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCellLPS_only-Unknown-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

E2F7 ACE2 HMGCS2 TRPC6

7.91e-07115284ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IFIH1 TRPM4 TRPC7 TSPAN1

4.50e-06178284e4e11e4940c911c17806200c25096928153c684d
ToppCell3'-GW_trimst-2-SmallIntestine|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNN3 LPGAT1 ACE2 TMEM176B

6.86e-06198284cc162ba4b3b8dec667a8cffd3411965f3f856f8c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCNN3 CORIN COL6A5 TRPC6

7.14e-0620028458b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-Unfolded_protein_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

LPGAT1 WDR64 TSPAN1

4.10e-051072837fee0193ee02e9cc62f506660ea7ec23fb4d0c84
ToppCell368C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

E2F7 IFIH1 E2F8

1.12e-04150283c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell368C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

E2F7 IFIH1 E2F8

1.12e-0415028378b8029e71d26f336a46274c8afef3435bf536b9
ToppCellfacs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM4 NLRC4 TRPM2

1.16e-04152283b61d2f6ee819c8dd4b4b601a8bc8388b1983de58
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

GHR COL6A5 TRPC6

1.28e-04157283f147e24f2ece82e1c54750868954d09b3c461804
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

E2F7 WDR64 E2F8

1.28e-041572831ccb07a38d3fb606ee5fbc0437655f49baaaa62c
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GHR COL6A5 TRPC6

1.31e-04158283e5636c0b608d68bd426a2b446ac508e4512e86a4
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR HMGCS2 TMEM176B

1.33e-04159283c34a7d227dbda2d7c76f937e1a58552b14bd40b5
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 TRPM8 WDR64

1.35e-04160283c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LPGAT1 OPN3 TRPM2

1.35e-041602835d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 TRPM8 WDR64

1.35e-0416028325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

GALNTL6 KCNN3 TRPC6

1.51e-041662836a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|343B / Donor, Lineage, Cell class and subclass (all cells)

E2F7 HMGCS2 OPN3

1.54e-041672837efa0081e79f22b219eac64ffcaedb2179cde299
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

E2F7 WDR64 E2F8

1.54e-04167283bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

E2F7 TRPM8 E2F8

1.59e-04169283a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPM4 TRPC7 TSPAN1

1.59e-041692838b3cc89e42957f18bfb30b8bba8df9ad997bf547
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 E2F7 E2F8

1.59e-04169283e7514956b2e4298222ec443f98b2f5289451786e
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

E2F7 TRPM8 E2F8

1.59e-04169283195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRPM8 WDR64 OPN3

1.62e-04170283db0ec8b7ecbb4db108fc35c564df4b740f65cc8f
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRPM8 WDR64 OPN3

1.62e-0417028388f6804e973863245ca1c7e5e6656d4a8b824da9
ToppCell3'-Airway_Nasal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TRPM8 WDR64 OPN3

1.62e-04170283dad3aaf7d9f7bafdbddee51610f03f2359e587ae
ToppCelldroplet-Kidney-KIDNEY-30m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR HMGCS2 TMEM176B

1.62e-04170283fb2771d37699c731fb569775e14a24b06ee60726
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 HMGCS2 TSPAN1

1.65e-04171283a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR HMGCS2 TMEM176B

1.76e-0417528313843bfc8efe7c01f19ebb6735609c1eec09c698
ToppCell10x3'2.3-week_17-19-Myeloid_macrophage-stroma-monocytoid_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DOCK3 CORIN C1orf43

1.76e-0417528379fd3e42c91846bda819e878a8eca8415d15ec55
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACE2 TRPM4 TSPAN1

1.76e-041752831d1984a03d0f04cd06048ed62d123033af364e82
ToppCellMid-temporal_gyrus_(MTG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GHR GALNTL6 KCNN3

1.85e-04178283ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell15-Trachea-Epithelial-Goblet-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

TMEM176B TSPAN1 TRPC6

1.85e-04178283f0557920b9b3e7c4f39938d1b524aa58711af4d2
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GHR COL6A5 TRPC6

1.95e-041812839ede19228ba5c0668a9c06c915510b95585216ef
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-club_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK3 ACE2 TSPAN1

1.95e-041812834a0f1b121570430afb100c589657d931184e124f
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-club_cell-club_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK3 ACE2 TSPAN1

1.95e-0418128334b49092f71128898af3b311170c4ed8adfefcff
ToppCellHealthy/Control-pDC|World / Disease group and Cell class

WDR64 OPN3 TSPAN1

1.98e-0418228397e0eee10905f2cf2bebb09e474629fc224f4397
ToppCelltumor_Lung-Myeloid_cells-CD207+CD1a+_LCs|tumor_Lung / Location, Cell class and cell subclass

TRPM4 OPN3 TRPC6

1.98e-04182283243779ba1009097f8fafa1a691e296ec3aeefc04
ToppCellfacs-Lung-EPCAM-18m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 ACE2 TSPAN1

1.98e-04182283f8eb35eb7f2b8ad47d527ae9ff8a9ddbcd2eedce
ToppCellfacs-Lung-EPCAM-18m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 ACE2 TSPAN1

1.98e-041822836685a0abd9c3a79d03b6a578e5d7fa86a9d74117
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GALNTL6 ACE2 TSPAN1

2.01e-04183283514b72a1ae55656934839800513385e19bc240e2
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGCS2 TSPAN1 TRPC6

2.01e-041832837eaa6ef7c6cf848fd6489f97677f4406318da22f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GHR ZDHHC6 TRPC6

2.01e-041832833c516fe5083f02bad1f464ed284010b4131a833c
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 TSPAN1 TRPC6

2.01e-0418328399ab7a43527eb226027efbcd8c0b6a8e46fc3c93
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GHR ZDHHC6 TRPC6

2.01e-041832839c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 TSPAN1 TRPC6

2.01e-0418328328916f0597690ff534578be2cb715b485cb1de1a
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

E2F7 TRPM8 E2F8

2.04e-041842836b2449ac65a2322aa0479fba0d89828f243aabbe
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GALNTL6 ACE2 TSPAN1

2.04e-0418428349eccf72725593a8fb4a529e7985a5c413b3ca6a
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GALNTL6 ACE2 TSPAN1

2.04e-0418428341164109d9d7bb1c431220e2e85e08dc5f56856d
ToppCell343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

E2F7 TRPM8 E2F8

2.04e-04184283e90622b82fa7f16a1faaf7a4724c958f2d83341d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GHR ZDHHC6 TRPC6

2.04e-041842837294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GHR DOCK3 TRPC6

2.08e-041852836712512100ccef456d2e2bd201d0987986c92ac9
ToppCell21-Trachea-Epithelial-Goblet-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

TRPM4 TMEM176B TSPAN1

2.11e-04186283f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACE2 TRPM4 TSPAN1

2.14e-0418728371d99a1a95d3692a2891da49d4a243bae6e07fd0
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GHR DOCK3 TRPC6

2.18e-04188283293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GHR DOCK3 TRPC6

2.21e-041892837ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell10x5'-GI_small-bowel-Myeloid_Dendritic-migDC|GI_small-bowel / Manually curated celltypes from each tissue

TMEM176B TSPAN1 TRPC6

2.25e-04190283e9b2c201d07f0cb87fa60005251c9e1663e246ed
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

E2F7 E2F8 TSPAN1

2.25e-041902830adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

E2F7 E2F8 TSPAN1

2.25e-0419028305455775845f4ded5c27e7b83242078d23162aaf
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR CORIN HMGCS2

2.25e-0419028396a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GHR HMGCS2 TSPAN1

2.28e-04191283b94e66ac71e73f46b0323d424e7b8b906751d584
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GHR DOCK3 TRPC6

2.28e-0419128308042952431ca1a6fd7dfc13f36eb28643979598
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

E2F7 KCNN3 E2F8

2.28e-04191283b23fdcd3090df9f58310b4dc8f7dc0c6d6b33226
ToppCellproximal-Hematologic-Plasmacytoid_Dendritic|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

WDR64 OPN3 TRPM2

2.32e-04192283faead5875a54fe8f1848ae36008aae4c0f7cb1c7
ToppCellproximal-3-Hematologic-Plasmacytoid_Dendritic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

WDR64 OPN3 TRPM2

2.32e-0419228386938c7d2bb1a7afb2b83828ca33dd137d366ec6
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGCS2 TMEM176B TSPAN1

2.32e-041922839f7e0d610741288d0779bd7c02852c791431e4ea
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GHR DOCK3 TRPC6

2.32e-04192283992d08092edbc68c47b945deb8708379738c239a
ToppCellproximal-Hematologic-Plasmacytoid_Dendritic-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

WDR64 OPN3 TRPM2

2.32e-04192283e3be395a995dc8c0ebdae754057cfa59a270cae0
ToppCelldistal-Hematologic-IGSF21+_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

E2F7 TMEM176B TRPM2

2.35e-0419328348ce11778252ae2ef902b30816061b59a3c81695
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

GHR COL6A5 TRPC6

2.35e-04193283ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCelldroplet-Lung-3m-Mesenchymal-myofibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CORIN TMEM176B TRPC6

2.39e-04194283c992e3357f4bf3069f8d697803e5785e49a2ef0a
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell|Adult / Lineage, Cell type, age group and donor

GHR COL6A5 TRPC6

2.42e-0419528361c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCelldroplet-Mammary_Gland-nan-18m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM176B TSPAN1 TRPC6

2.42e-04195283c771ac1db8bd5f3a80bd3484094a58c28983f97b
ToppCellproximal-3-Hematologic-IGSF21+_Dendritic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TMEM176B NLRC4 TRPM2

2.42e-041952838592d0332bc82a91e173680cfd1afc5ee189b289
ToppCellproximal-Hematologic-IGSF21+_Dendritic|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TMEM176B NLRC4 TRPM2

2.42e-04195283c48ff83c48342875f06c6c9e7d5bc6084a992848
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN COL6A5 TMEM176B

2.42e-0419528351db90e7611f7d69980878c046505ff34212079b
ToppCellproximal-Hematologic-IGSF21+_Dendritic-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TMEM176B NLRC4 TRPM2

2.42e-04195283ae9d61011e95f7840cbb154738c79745fd29943e
ToppCelldroplet-Mammary_Gland-nan-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM176B TSPAN1 TRPC6

2.42e-0419528318220efbd2d6ce6aa7501744fe430b6b46f2fc30
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN COL6A5 TMEM176B

2.46e-04196283e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN COL6A5 TMEM176B

2.46e-0419628382fad623212d986a7fca3496faf3f8c8f5b83a11
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Mucous|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRPM4 HMGCS2 TSPAN1

2.46e-0419628398e3f9c886063def16c74ab75fc81511a7872f1c
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CORIN COL6A5 TMEM176B

2.46e-0419628385e5046f774537684e1443c0fc147d562b7068d0
ToppCellEnterocyte-C_05|Enterocyte / shred on cell type and cluster

IFIH1 HMGCS2 TSPAN1

2.46e-04196283c307e5a70186567c62da938caa21749dc0e929d0
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Mucous-Mucous|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRPM4 HMGCS2 TSPAN1

2.46e-04196283357a5440aeebf69688bfe9fbc8585950ad00906b
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

E2F7 TMEM176B TRPM2

2.50e-041972830a404b4494a2246d5a92299235056f0fda4d2b48
ToppCellBronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

E2F7 TMEM176B OPN3

2.50e-0419728368d8546dfe7dffd017756a11d3333061f576d0ef
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACE2 TMEM176B TSPAN1

2.54e-04198283be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK3 TMEM176B NLRC4

2.54e-041982839430ce7016b1a4724de036aab3e3e4082d24e436
ToppCell5'-Adult-LargeIntestine-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRPM4 HMGCS2 TSPAN1

2.57e-04199283156354b799346d441dde42dbba09d7bde89ad460
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM176B NLRC4 TRPM2

2.57e-04199283368e2bafae00ce8e9c6ea480f81b78f96b680acd
ToppCellbackground-Hepatocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

GHR HMGCS2 TMEM176B

2.61e-04200283423cca10df6ae0489a8fe7e7df87e70364dac022
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM176B NLRC4 TRPM2

2.61e-04200283c210b98a75ab5d899d7278bc9b577f76a0b3970c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ACE2 TMEM176B TSPAN1

2.61e-04200283105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GALNTL6 TRPM4 HMGCS2

2.61e-04200283c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM176B NLRC4 TRPM2

2.61e-042002833cfb28299a55fc1c150262a7333c59a48ae65ad1
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

CORIN COL6A5 TMEM176B

2.61e-0420028316a3685c41194a0a4a772e4eee372160263480e0
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CORIN COL6A5 TMEM176B

2.61e-042002838ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LPGAT1 ACE2 HMGCS2

2.61e-042002830ca955b71b97571b45e9e89004f1d0bb9fc9e67b
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

GHR DOCK3 TRPC6

2.61e-042002835ed4261157cd51109b314818133ac3a0d34ee5fa
DrugCalcium

GHR KCNN3 TRPM4 TRPM8 HMGCS2 TRPC7 TRPC6 TRPM2

9.70e-08493288ctd:D002118
Drugbosentan

TRPM4 TRPM8 TRPC7 TRPC6 TRPM2

1.79e-07106285CID000104865
DrugN-(p-amylcinnamoyl)anthranilic acid

TRPM8 TRPC6 TRPM2

6.01e-0714283CID000001974
DrugSurfagon

GHR TRPC7 TRPC6

8.87e-0633283CID005484741
Drugflufenamic acid

TRPM4 TRPC7 TRPC6 TRPM2

8.98e-06108284CID000003371
Drug2-aminoethyl diphenylborinate

TRPM4 TRPM8 TRPC7 TRPC6

1.70e-05127284CID000001598
DrugAla-Trp

GHR ACE2

2.18e-056282CID000085362
DrugFlufenamic Acid

TRPM4 TRPC6 TRPM2

2.28e-0545283ctd:D005439
DrugAC1L96VB

TRPM4 TRPM8 TRPC6 TRPM2

8.39e-05191284CID000439200
DrugIron

HMGCS2 OPN3 E2F8 NLRC4 TRPC6

9.26e-05382285ctd:D007501
Diseasemastiha supplement exposure measurement, interleukin-6 measurement

TRPC7 TRPM2

5.20e-064282EFO_0004810, EFO_0600067
Diseasenicotine dependence (implicated_via_orthology)

TRPC7 TRPC6

5.70e-0512282DOID:0050742 (implicated_via_orthology)
Diseaseperipheral neuropathy, response to docetaxel trihydrate

TRPC7 TRPM2

1.47e-0419282EFO_0003100, GO_1902519
Diseasetreatment resistant depression, response to antidepressant

WDR64 OPN3

1.80e-0421282EFO_0009854, GO_0036276
Diseasepuberty onset measurement

DOCK3 TRPC7 TRPM2

2.25e-04125283EFO_0005677
DiseaseAutoinflammatory disorder

IFIH1 NLRC4

5.07e-0435282C3860213
Diseasetestosterone measurement

DOCK3 TRPC7 TMEM176B ZDHHC6 NLRC4 TRPM2

1.07e-031275286EFO_0004908
Diseasesquamous cell lung carcinoma, family history of lung cancer

GHR GALNTL6

2.95e-0385282EFO_0000708, EFO_0006953
Diseasedepressive symptom measurement, response to antidepressant

WDR64 OPN3

3.16e-0388282EFO_0007006, GO_0036276

Protein segments in the cluster

PeptideGeneStartEntry
MIKFFLMVNKQGQTR

AP4S1

1

Q9Y587
VKALMRFAFMVVNNL

LPGAT1

16

Q92604
TFMAMLLKLRQRVLF

NLRC4

231

Q9NPP4
KMVQKSLARLMFNDF

HMGCS2

306

P54868
NKINFNTRFVMKTLM

KCNN3

441

Q9UGI6
KKLAKMCFLMIFTFL

OPN3

251

Q9H1Y3
LLFIFVKRQIMRFAM

C1orf43

26

Q9BWL3
SLRIMSQKFVMLFLV

E2F7

286

Q96AV8
LRVMSQKFVMLFLVS

E2F8

266

A0AVK6
FLLKIFCVFRNLMKM

DOCK3

976

Q8IZD9
MLFVFLFSKQQRIKM

GHR

281

P10912
NENFRKMKIFMKNLL

COL6A5

641

A8TX70
LMTLFFENNKMLKRL

IFIH1

676

Q9BYX4
MRQYFLKVKNQMILF

ACE2

651

Q9BYF1
SVVRNMEMEKFLKFF

CORIN

161

Q9Y5Q5
MVQIPFSMKNLKINF

PMS1

696

P54277
MKRKQKRFLQMTLLF

GALNTL6

1

Q49A17
MQMLRKLFTAIRALF

TMEM176B

196

Q3YBM2
GMLFFIQMKIILRNK

ZDHHC6

221

Q9H6R6
LMQLDFQQFLMKLEK

VPS50

876

Q96JG6
IVKRMMKDVFFFLFL

TRPM2

926

O94759
FRKALKMMLFGKIFQ

TAAR1

311

Q96RJ0
VKDIFKFMVIFIMVF

TRPC6

631

Q9Y210
KIIMLQRMLIDVFFF

TRPM8

856

Q7Z2W7
VIVSKMMKDVFFFLF

TRPM4

921

Q8TD43
VKDIFKFMVIFIMVF

TRPC7

576

Q9HCX4
MALQMSNFKKALNRF

WDR64

11

B1ANS9
FIKTMMILFNLLIFL

TSPAN1

6

O60635