Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein de-2-hydroxyisobutyrylase activity	HDAC3 HDAC2	2.81e-06	2	34	2	GO:0160010
GeneOntologyMolecularFunction	protein decrotonylase activity	HDAC3 HDAC2	2.81e-05	5	34	2	GO:0160008
GeneOntologyMolecularFunction	histone decrotonylase activity	HDAC3 HDAC2	2.81e-05	5	34	2	GO:0160009
GeneOntologyMolecularFunction	transition metal ion binding	TRHDE KDM4A LHX5 UPB1 MMP2 TRIM6 P2RX4 MUC2 FA2H	1.23e-04	1189	34	9	GO:0046914
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	1.26e-04	10	34	2	GO:0001849
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	HDAC3 UPB1 HDAC2	3.51e-04	81	34	3	GO:0016811
GeneOntologyMolecularFunction	zinc ion binding	TRHDE KDM4A LHX5 UPB1 MMP2 TRIM6 P2RX4	6.43e-04	891	34	7	GO:0008270
GeneOntologyMolecularFunction	histone deacetylase activity	HDAC3 HDAC2	7.59e-04	24	34	2	GO:0004407
GeneOntologyMolecularFunction	opsonin binding	C4A C4B	8.24e-04	25	34	2	GO:0001846
GeneOntologyMolecularFunction	protein lysine deacetylase activity	HDAC3 HDAC2	8.24e-04	25	34	2	GO:0033558
GeneOntologyMolecularFunction	complement binding	C4A C4B	1.35e-03	32	34	2	GO:0001848
GeneOntologyMolecularFunction	NF-kappaB binding	HDAC3 HDAC2	1.71e-03	36	34	2	GO:0051059
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	HDAC3 UPB1 HDAC2	1.94e-03	146	34	3	GO:0016810
GeneOntologyMolecularFunction	deacetylase activity	HDAC3 HDAC2	2.11e-03	40	34	2	GO:0019213
GeneOntologyMolecularFunction	cysteine-type peptidase activity	TRHDE MALT1 DESI2	4.21e-03	192	34	3	GO:0008234
GeneOntologyMolecularFunction	transcription corepressor binding	HDAC3 HDAC2	4.53e-03	59	34	2	GO:0001222
GeneOntologyMolecularFunction	histone modifying activity	HDAC3 KDM4A HDAC2	6.85e-03	229	34	3	GO:0140993
GeneOntologyBiologicalProcess	response to fluid shear stress	HDAC3 MMP2 P2RX4	2.36e-05	35	33	3	GO:0034405
GeneOntologyBiologicalProcess	cornified envelope assembly	HDAC3 DMKN	5.19e-05	7	33	2	GO:1903575
GeneOntologyBiologicalProcess	gliogenesis	ANO1 KDM4A P2RX4 FA2H ARSG HDAC2	5.81e-05	435	33	6	GO:0042063
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	6.91e-05	8	33	2	GO:2000427
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	1.11e-04	10	33	2	GO:2000425
GeneOntologyBiologicalProcess	macromolecule deacylation	HDAC3 DESI2 HDAC2	1.39e-04	63	33	3	GO:0098732
GeneOntologyBiologicalProcess	glial cell differentiation	ANO1 KDM4A FA2H ARSG HDAC2	1.47e-04	321	33	5	GO:0010001
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	6.73e-05	8	33	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	8.64e-05	9	33	2	GO:0044217
GeneOntologyCellularComponent	transcription repressor complex	HDAC3 CDX2 HDAC2	3.47e-04	87	33	3	GO:0017053
Domain	His_deacetylse_1	HDAC3 HDAC2	1.93e-05	4	34	2	IPR003084
Domain	Anaphylatoxin_comp_syst	C4A C4B	3.21e-05	5	34	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	3.21e-05	5	34	2	IPR001840
Domain	ANATO	C4A C4B	6.72e-05	7	34	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	6.72e-05	7	34	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	6.72e-05	7	34	2	PS01177
Domain	ANATO	C4A C4B	6.72e-05	7	34	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	6.72e-05	7	34	2	IPR000020
Domain	MacrogloblnA2_CS	C4A C4B	8.95e-05	8	34	2	IPR019742
Domain	Thiol-ester_cl	C4A C4B	8.95e-05	8	34	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	8.95e-05	8	34	2	IPR019565
Domain	A2M_N	C4A C4B	1.43e-04	10	34	2	PF01835
Domain	A2M_N_2	C4A C4B	1.43e-04	10	34	2	PF07703
Domain	A2M_N	C4A C4B	1.43e-04	10	34	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.43e-04	10	34	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.43e-04	10	34	2	PS00477
Domain	A2M_recep	C4A C4B	1.43e-04	10	34	2	PF07677
Domain	A2M_comp	C4A C4B	1.43e-04	10	34	2	PF07678
Domain	A2M	C4A C4B	1.43e-04	10	34	2	PF00207
Domain	A2M_N_2	C4A C4B	1.43e-04	10	34	2	IPR011625
Domain	A2M_comp	C4A C4B	1.43e-04	10	34	2	IPR011626
Domain	Macroglobln_a2	C4A C4B	1.43e-04	10	34	2	IPR001599
Domain	His_deacetylse_dom	HDAC3 HDAC2	1.75e-04	11	34	2	IPR023801
Domain	Hist_deacetyl	HDAC3 HDAC2	1.75e-04	11	34	2	PF00850
Domain	-	HDAC3 HDAC2	1.75e-04	11	34	2	3.40.800.20
Domain	His_deacetylse	HDAC3 HDAC2	1.75e-04	11	34	2	IPR000286
Domain	Homeobox_CS	HOXA13 LHX5 CDX2 IRX5	3.50e-04	186	34	4	IPR017970
Domain	C345C	C4A C4B	4.30e-04	17	34	2	SM00643
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	4.83e-04	18	34	2	IPR008930
Domain	NTR	C4A C4B	5.39e-04	19	34	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	5.39e-04	19	34	2	IPR018933
Domain	Netrin_domain	C4A C4B	7.95e-04	23	34	2	IPR001134
Domain	NTR	C4A C4B	7.95e-04	23	34	2	PS50189
Domain	Homeobox	HOXA13 LHX5 CDX2 IRX5	8.29e-04	234	34	4	PF00046
Domain	HOMEOBOX_1	HOXA13 LHX5 CDX2 IRX5	8.56e-04	236	34	4	PS00027
Domain	HOX	HOXA13 LHX5 CDX2 IRX5	8.69e-04	237	34	4	SM00389
Domain	Homeobox_dom	HOXA13 LHX5 CDX2 IRX5	8.97e-04	239	34	4	IPR001356
Domain	HOMEOBOX_2	HOXA13 LHX5 CDX2 IRX5	8.97e-04	239	34	4	PS50071
Domain	TIMP-like_OB-fold	C4A C4B	1.02e-03	26	34	2	IPR008993
Domain	-	HOXA13 LHX5 CDX2 IRX5	1.67e-03	283	34	4	1.10.10.60
Domain	Homeodomain-like	HOXA13 LHX5 CDX2 IRX5	2.99e-03	332	34	4	IPR009057
Domain	HTH_motif	LHX5 CDX2	6.99e-03	69	34	2	IPR000047
Domain	Ig_2	MALT1 CNTN5	7.80e-03	73	34	2	PF13895
Pathway	KEGG_MEDICUS_VARIANT_CDX2_OVEREXPRESSION_TO_TRANSCRIPTIONAL_ACTIVATION	CDX2 MUC2	3.52e-05	5	27	2	M48976
Pathway	REACTOME_P75NTR_NEGATIVELY_REGULATES_CELL_CYCLE_VIA_SC1	HDAC3 HDAC2	5.27e-05	6	27	2	M27072
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	7.38e-05	7	27	2	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	9.82e-05	8	27	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	9.82e-05	8	27	2	M47872
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	1.92e-04	11	27	2	MM1430
Pathway	REACTOME_STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING	HDAC3 HDAC2	1.92e-04	11	27	2	M42523
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	1.92e-04	11	27	2	M47874
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	2.30e-04	12	27	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	2.72e-04	13	27	2	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	3.65e-04	15	27	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	4.72e-04	17	27	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	4.72e-04	17	27	2	MM1369
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	6.57e-04	20	27	2	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	7.97e-04	22	27	2	M39502
Pathway	WP_NEURAL_CREST_DIFFERENTIATION	HDAC3 LHX5 HDAC2	8.19e-04	97	27	3	MM15926
Pathway	WP_NEURAL_CREST_DIFFERENTIATION	HDAC3 LHX5 HDAC2	9.21e-04	101	27	3	M39448
Pathway	BIOCARTA_CARM_ER_PATHWAY	HDAC3 HDAC2	1.12e-03	26	27	2	M2499
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	HDAC3 HDAC2	1.29e-03	28	27	2	M6177
Pathway	REACTOME_SIGNALING_BY_ALK	HDAC3 HDAC2	1.49e-03	30	27	2	M42517
Pathway	WP_ETHANOL_EFFECTS_ON_HISTONE_MODIFICATIONS	HDAC3 HDAC2	1.59e-03	31	27	2	M39714
Pathway	WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR	HDAC3 HDAC2	1.69e-03	32	27	2	M39521
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	HDAC3 HDAC2	1.69e-03	32	27	2	M27900
Pathway	REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX	HDAC3 KDM4A	2.26e-03	37	27	2	M29790
Pathway	WP_OXIDATIVE_DAMAGE_RESPONSE	C4A C4B	2.90e-03	42	27	2	MM15945
Pubmed	Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.	HDAC3 KDM4A HDAC2	1.70e-08	6	34	3	15927959
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	9.28e-07	2	34	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	9.28e-07	2	34	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	9.28e-07	2	34	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	9.28e-07	2	34	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	9.28e-07	2	34	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	9.28e-07	2	34	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	9.28e-07	2	34	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	9.28e-07	2	34	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	9.28e-07	2	34	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	9.28e-07	2	34	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	9.28e-07	2	34	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	9.28e-07	2	34	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	9.28e-07	2	34	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	9.28e-07	2	34	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	9.28e-07	2	34	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	9.28e-07	2	34	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	9.28e-07	2	34	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	9.28e-07	2	34	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	9.28e-07	2	34	2	20506482
Pubmed	CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia?	CDX2 MUC2	9.28e-07	2	34	2	23011828
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	9.28e-07	2	34	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	9.28e-07	2	34	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	9.28e-07	2	34	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	9.28e-07	2	34	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	9.28e-07	2	34	2	15390104
Pubmed	TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes.	ANO1 TRPV3	9.28e-07	2	34	2	36690845
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	9.28e-07	2	34	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	9.28e-07	2	34	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	9.28e-07	2	34	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	9.28e-07	2	34	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	9.28e-07	2	34	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	9.28e-07	2	34	2	2997024
Pubmed	Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.	CDX2 MUC2	9.28e-07	2	34	2	14525978
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	9.28e-07	2	34	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	9.28e-07	2	34	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	9.28e-07	2	34	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	9.28e-07	2	34	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	9.28e-07	2	34	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	9.28e-07	2	34	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	9.28e-07	2	34	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	9.28e-07	2	34	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	9.28e-07	2	34	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	9.28e-07	2	34	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	9.28e-07	2	34	2	7545960
Pubmed	Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.	HDAC3 HDAC2	9.28e-07	2	34	2	26359372
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	9.28e-07	2	34	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	9.28e-07	2	34	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	9.28e-07	2	34	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	9.28e-07	2	34	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	9.28e-07	2	34	2	34358307
Pubmed	Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus.	HDAC3 HDAC2	9.28e-07	2	34	2	21453528
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	9.28e-07	2	34	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	9.28e-07	2	34	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	9.28e-07	2	34	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	9.28e-07	2	34	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	9.28e-07	2	34	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	9.28e-07	2	34	2	6589636
Pubmed	Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression.	CDX2 MUC2	9.28e-07	2	34	2	12559945
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	9.28e-07	2	34	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	9.28e-07	2	34	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	9.28e-07	2	34	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	9.28e-07	2	34	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	9.28e-07	2	34	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	9.28e-07	2	34	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	9.28e-07	2	34	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	9.28e-07	2	34	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	9.28e-07	2	34	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	9.28e-07	2	34	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	9.28e-07	2	34	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	9.28e-07	2	34	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	9.28e-07	2	34	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	9.28e-07	2	34	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	9.28e-07	2	34	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	9.28e-07	2	34	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	9.28e-07	2	34	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	9.28e-07	2	34	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	9.28e-07	2	34	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	9.28e-07	2	34	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	9.28e-07	2	34	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	9.28e-07	2	34	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	9.28e-07	2	34	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	9.28e-07	2	34	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	9.28e-07	2	34	2	6881182
Pubmed	Selective HDAC inhibition for the disruption of latent HIV-1 infection.	HDAC3 HDAC2	9.28e-07	2	34	2	25136952
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	9.28e-07	2	34	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	9.28e-07	2	34	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	9.28e-07	2	34	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	9.28e-07	2	34	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	9.28e-07	2	34	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	9.28e-07	2	34	2	33353966
Pubmed	Does HepPar-1 immunoexpression have a role in differential diagnosis of periampullary cancer?	CDX2 MUC2	9.28e-07	2	34	2	18038313
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	9.28e-07	2	34	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	9.28e-07	2	34	2	28873507
Pubmed	Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis.	CDX2 MUC2	9.28e-07	2	34	2	15048136
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	9.28e-07	2	34	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	9.28e-07	2	34	2	2900855
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	9.28e-07	2	34	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	9.28e-07	2	34	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	9.28e-07	2	34	2	3794341
Cytoband	Ensembl 112 genes in cytogenetic band chr16q12	MMP2 IRX5	2.67e-03	103	34	2	chr16q12
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	ANO1 SIPA1 UVRAG	4.58e-03	454	34	3	chr11q13
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	HDAC3 HDAC2	1.19e-05	4	26	2	989
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	7.11e-05	9	26	2	1234
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	1.22e-03	36	26	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	1.28e-03	37	26	2	454
GeneFamily	HOXL subclass homeoboxes	HOXA13 CDX2	2.52e-03	52	26	2	518
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	DOCK2 PDIA5 KDM4A GSAP UVRAG	5.31e-06	197	34	5	M7403
Coexpression	GSE7764_IL15_TREATED_VS_CTRL_NK_CELL_24H_DN	UPB1 GSAP P2RX4 ARSG ACSS1	5.72e-06	200	34	5	M5724
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALT1 C4A C4B ACSS1	2.31e-06	123	34	4	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 KDM4A UPB1 UVRAG	8.95e-06	173	34	4	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 KDM4A UPB1 UVRAG	8.95e-06	173	34	4	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 UPB1 P2RX4	1.00e-05	178	34	4	07d6d5275a4d17f8024fde74e92ab2505b4adfbf
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 TRPV3 P2RX4	1.05e-05	180	34	4	a0faed4cf23f6d5e6e8f6b0284cea8a5bd0680a0
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 UPB1 P2RX4	1.17e-05	185	34	4	e29079ef09aee62c3e9756341db4e59ca9dbf7ac
ToppCell	facs-Large_Intestine-Distal-24m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 UPB1 P2RX4	1.17e-05	185	34	4	2ecc4b76b3645b65c226c2298bff307cc6479172
ToppCell	facs-Large_Intestine-Distal-18m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 UPB1 P2RX4	1.22e-05	187	34	4	a4c408fc941d2e8a811a26aa916c0b3e3341163a
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 UPB1 P2RX4	1.22e-05	187	34	4	ab109aa51beae3df474c15002e70361f328cadad
ToppCell	Mesenchymal_cells-Osteoblasts\|World / Lineage and Cell class	ANO1 PDIA5 MMP2 IRX5	1.24e-05	188	34	4	89f7f5a51be7e046a63e2413f86c521ae4b6718f
ToppCell	facs-Large_Intestine-Distal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 UPB1 P2RX4	1.29e-05	190	34	4	3964a8390522b61b73235151bb0a2ff36b856867
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GSAP IRX5 DMKN FA2H	1.43e-05	195	34	4	98dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LHX5 MMP2 IRX5	4.28e-05	89	34	3	9e7041ab9409028007fefe53db6d1048eafae93b
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LHX5 MMP2 IRX5	4.28e-05	89	34	3	e7abf4af18d63c9384d25365a827e85a9adee964
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LHX5 MMP2 IRX5	4.28e-05	89	34	3	436e1229ee28517c11dfe0a5d1cdad3477419e00
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LHX5 MMP2 IRX5	4.28e-05	89	34	3	4e5f4c0404968422703c248488e6b2ee8737dc00
ToppCell	primary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Rassf10\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MMP2 IRX5 FA2H	5.20e-05	95	34	3	0ac6cba7e0ed6083f777287f39a871461fa1bca4
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	GATB C4A MMP2	1.54e-04	137	34	3	25b5370b63644351efddb8749ef174beca0581cd
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	1.90e-04	147	34	3	aba44c7057096483c4293a7ebcf8ccc8baed0231
ToppCell	facs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MALT1 GSAP CNTN5	2.09e-04	152	34	3	931c10245cde9b3290224cc1da46b2bf300b9ac2
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TRHDE ANO1 DMKN	2.26e-04	156	34	3	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ANKRD36B FA2H CNTN5	2.26e-04	156	34	3	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TRHDE ANO1 DMKN	2.26e-04	156	34	3	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANO1 HOXA13 CNTN5	2.48e-04	161	34	3	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 TRPV3 FA2H	2.53e-04	162	34	3	bc63a96ad3ba0b3433e3679d7a005f47709ff384
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDIA5 TENM3 DMKN	2.53e-04	162	34	3	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	P07-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	2.71e-04	166	34	3	021b9344de7957762f81b09a647504b8c8289cf1
ToppCell	facs-Brain_Myeloid-Cerebellum_-18m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B P2RX4 ARSG	2.71e-04	166	34	3	4ab1959c526c2fd83077fc03e4de207f34841a19
ToppCell	Club-club-2\|World / Class top	ANO1 UPB1 P2RX4	2.71e-04	166	34	3	56f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 TRPV3 TRIM6	2.81e-04	168	34	3	03896466698a79f7f1ad862cb7e05585260e2a5a
ToppCell	367C-Epithelial_cells-Epithelial-B_(AT2)\|367C / Donor, Lineage, Cell class and subclass (all cells)	IRX5 DMKN FA2H	2.81e-04	168	34	3	e20e1936573fdde78426d7a4eb45c458d5c4dbb4
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C4A C4B MMP2	2.81e-04	168	34	3	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	367C-Epithelial_cells-Epithelial-B_(AT2)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	IRX5 DMKN FA2H	2.81e-04	168	34	3	16b517e3159ad6e6d25fd48f7d5f46e77b2b318d
ToppCell	P07-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	2.86e-04	169	34	3	53e863de064d44e1d36e21fb3dbba37ae020f6e9
ToppCell	P07-Epithelial-epithelial_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	2.86e-04	169	34	3	ec23caecbb0d969307e33e9df8499ddcd1420305
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 MMP2 CNTN5	2.86e-04	169	34	3	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	P15-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	2.91e-04	170	34	3	6c0619cbe2f01a6de18da0a137f92bda0cbdf075
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANO1 HOXA13 CNTN5	3.01e-04	172	34	3	553701349444eb366df3c11f54bb093434f153c6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANO1 HOXA13 CNTN5	3.01e-04	172	34	3	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C4B TENM3 DMKN	3.06e-04	173	34	3	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	P07-Epithelial\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	3.06e-04	173	34	3	8b10087a917b825809d35a2b2b349c73a2782472
ToppCell	P03-Epithelial-epithelial_progenitor_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	3.11e-04	174	34	3	23c7fdfc73170cfc5cdee5bb7fbee0c8bbbbca07
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DESI2 MMP2 ETNK2	3.11e-04	174	34	3	e5f12831187140e84b9a49e93b2376b9fefb1aec
ToppCell	P07-Epithelial-alveolar_epithelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	3.11e-04	174	34	3	2739de68e0266054694f99807cfb1f07b6bbb371
ToppCell	P28-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 ACSS1	3.17e-04	175	34	3	8a4ed775ff973123dbcfe9c809959d11a62450c9
ToppCell	P03-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	3.17e-04	175	34	3	a6d9ca35d3c4b4e3889d0a69b514f63ae630da6b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDIA5 TENM3 DMKN	3.17e-04	175	34	3	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	(03)_Secretory\|World / shred by cell type and Timepoint	ANO1 P2RX4 ACSS1	3.22e-04	176	34	3	cb7b1945788196ca79007f0768b6576ec885a0e5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO1 LHX5 CNTN5	3.33e-04	178	34	3	c982a73955c9c193bcab21d60d453afcc09cd586
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE IRX5 DMKN	3.33e-04	178	34	3	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	ASK440-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	TRHDE MALT1 MMP2	3.33e-04	178	34	3	86f1741636ed3e85bb4a65f84949b718fc38c290
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE DMKN CNTN5	3.33e-04	178	34	3	5522b179c2e7dd707de01e2df10556349d0382a6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE DMKN CNTN5	3.33e-04	178	34	3	f7f88879a05b2b5fa92cf5317b76f7a3064d1358
ToppCell	P15-Epithelial\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	3.38e-04	179	34	3	869d3d203e2cb88636e2f0c4476c72571ae3b5ca
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE DMKN CNTN5	3.44e-04	180	34	3	2ae39e26a8e7d5d4d3e1e71609a8ec36fd9855aa
ToppCell	facs-SCAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B MMP2 IRX5	3.44e-04	180	34	3	6c70b6b7480507fa94625013222ad338ee7dd1d9
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANO1 LHX5 CNTN5	3.50e-04	181	34	3	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE IRX5 CNTN5	3.50e-04	181	34	3	071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPV3 C4B MMP2	3.50e-04	181	34	3	6730e249cac55ae892cc567d9211615882f3dab4
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	ANO1 PDIA5 UPB1	3.50e-04	181	34	3	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPV3 C4B MMP2	3.50e-04	181	34	3	3462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 UPB1 P2RX4	3.50e-04	181	34	3	dae0d106f0eee5dba538617f8ed724925ea35f17
ToppCell	P15-Epithelial-alveolar_epithelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GSAP IRX5 DMKN	3.50e-04	181	34	3	7033be0ba90556f7e5f7c0d4a9f7644afcb22c9b
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANO1 MMP2 ARSG	3.50e-04	181	34	3	d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 UPB1 P2RX4	3.50e-04	181	34	3	75340f0c06977c88f9d2e56265f4aa84d706d2c6
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-migDC\|lymph-node_spleen / Manually curated celltypes from each tissue	CDX2 UPB1 TENM3	3.50e-04	181	34	3	94680f8dbdf22d83801abc0819417751d363fb12
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	ANO1 PDIA5 UPB1	3.55e-04	182	34	3	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	Control-Epithelial_alveolar-AT_2-AT2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDIA5 GSAP IRX5	3.55e-04	182	34	3	e97681a4102f3095d5d9e90ad70f1dc46e90983a
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK2 GSAP ARSG	3.55e-04	182	34	3	243c783675df495ea4112dbf710712c44ea6b4f1
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK2 GSAP ARSG	3.55e-04	182	34	3	18790a394dc32b3cef99cdbf826392c520e38b4a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE IRX5 CNTN5	3.61e-04	183	34	3	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE DMKN CNTN5	3.61e-04	183	34	3	b5d041d0a3506c33de72bf14fa0443f4410fddf1
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 P2RX4 DMKN	3.61e-04	183	34	3	e32847cfebba7c8bb2026e33c3c85f64819460a9
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 P2RX4 ARSG	3.61e-04	183	34	3	07c18ccc45ddc9c22e482bd9ffb87f46ebcfe473
ToppCell	facs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANO1 IRX5 DMKN	3.61e-04	183	34	3	6e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE DMKN CNTN5	3.61e-04	183	34	3	274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 P2RX4 ARSG	3.61e-04	183	34	3	5a936fb07074cec753bf19e3e3e52499605ea22c
ToppCell	droplet-Marrow-nan-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDIA5 P2RX4 DMKN	3.61e-04	183	34	3	b5782b18decfe85026acf42daac0670d92385861
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 P2RX4	3.61e-04	183	34	3	ee9c88be88221b7ad4ea9f890b17d6156fb3432e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE IRX5 CNTN5	3.61e-04	183	34	3	92fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C4B FA2H ARSG	3.61e-04	183	34	3	eb1f1dd12d1e4f1a7029b5396baada23f7c971ff
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 MMP2 CNTN5	3.61e-04	183	34	3	f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO1 MMP2 TRIM6	3.61e-04	183	34	3	269afec240a756eec3bbae5f30ec784281af3433
ToppCell	droplet-Large_Intestine-COLON:P+D-30m-Epithelial-Goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 P2RX4	3.61e-04	183	34	3	c52b84034503d931f7b87312d2ff86daff14152d
ToppCell	Mesenchymal_cells-Smooth_muscle\|Mesenchymal_cells / Lineage and Cell class	ANO1 ACSS1 ETNK2	3.67e-04	184	34	3	83987abaedc26e6da477bc70d65e10b1ab1aea60
ToppCell	Control-Epithelial_alveolar-AT_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDIA5 GSAP IRX5	3.67e-04	184	34	3	51e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 P2RX4	3.73e-04	185	34	3	fd1911b57927c03470f9387962ca9581e5643fb3
ToppCell	Control-Epithelial_alveolar-AT_2-AT2_Progenitor\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDIA5 GSAP IRX5	3.73e-04	185	34	3	8ca1374501eca01d8468130b74d50abfd4329fbe
ToppCell	facs-Large_Intestine-Distal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 P2RX4	3.73e-04	185	34	3	7a18d525de6f874924bfc61b9666b307da86421a
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 IRX5 FA2H	3.79e-04	186	34	3	3c4994a1a7db06a61da8170e45e06aaef7896592
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 PDIA5 P2RX4	3.79e-04	186	34	3	32d30f08b20a0a28e38b37bd52ab26d1d43736ce
ToppCell	facs-Lung-EPCAM-24m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO1 IRX5 FA2H	3.79e-04	186	34	3	a583d6fc0f1e729f6e9fd18d7b49d6eab9ca32b9
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C4A MMP2 DMKN	3.79e-04	186	34	3	d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDIA5 GSAP IRX5	3.79e-04	186	34	3	e83718fabb057100835d3357df407f283d23fe16
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK2 TENM3 UVRAG	3.85e-04	187	34	3	d69f4eee0304a7db226275ab77fc9d5d2b6f3a07
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MMP2 SIPA1 ACSS1	3.85e-04	187	34	3	b51af2824e65734f333b1325117f4a2e88b17c23
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-B_lymphocytic-plasma_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PDIA5 C4A C4B	3.85e-04	187	34	3	c80e03d5aa498b4eecbc46565fabf9b5be10c71c
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GSAP IRX5 FA2H	3.85e-04	187	34	3	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	Control-Myeloid-DC_Mature\|World / Disease state, Lineage and Cell class	MALT1 UPB1 UVRAG	3.85e-04	187	34	3	51bfc450e78284796b02317e91830357850b5437
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	TRHDE ANO1 TENM3	3.85e-04	187	34	3	92d468dde81125d51daf7abd4703741abe1ab91c
Drug	2-aminothiophenol	C4A C4B	6.49e-06	3	34	2	ctd:C005464
Disease	pulmonary emphysema (biomarker_via_orthology)	MMP2 HDAC2	1.93e-05	6	34	2	DOID:9675 (biomarker_via_orthology)
Disease	alopecia areata (is_marker_for)	KDM4A HDAC2	5.77e-05	10	34	2	DOID:986 (is_marker_for)
Disease	Barrett's esophagus (is_marker_for)	CDX2 MUC2	7.04e-05	11	34	2	DOID:9206 (is_marker_for)
Disease	sensory perception of sweet taste	KDM4A DMKN CNTN5	1.16e-04	82	34	3	GO_0050916
Disease	endometriosis (biomarker_via_orthology)	MMP2 HDAC2	1.53e-04	16	34	2	DOID:289 (biomarker_via_orthology)
Disease	prostate carcinoma (is_marker_for)	HDAC3 HDAC2	3.21e-04	23	34	2	DOID:10286 (is_marker_for)
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	GATB CNTN5	3.50e-04	24	34	2	EFO_0006821, EFO_0006826
Disease	Complement deficiency disease	C4A C4B	6.65e-04	33	34	2	C0272242
Disease	liver cirrhosis (biomarker_via_orthology)	MMP2 MUC2	7.06e-04	34	34	2	DOID:5082 (biomarker_via_orthology)
Disease	Graves' disease (is_implicated_in)	C4A C4B	9.30e-04	39	34	2	DOID:12361 (is_implicated_in)
Disease	dilated cardiomyopathy (is_marker_for)	MMP2 IRX5	9.30e-04	39	34	2	DOID:12930 (is_marker_for)
Disease	cervix uteri carcinoma in situ (is_marker_for)	MMP2 HDAC2	1.08e-03	42	34	2	DOID:8991 (is_marker_for)
Disease	systemic lupus erythematosus (implicated_via_orthology)	C4A C4B	1.13e-03	43	34	2	DOID:9074 (implicated_via_orthology)
Disease	adipose tissue measurement	TRHDE CNTN5	1.24e-03	45	34	2	EFO_0004764

Protein segments in the cluster

Peptide	Gene	Start	Entry
AHYFEFVGTDYLYPG	TRHDE	466	Q9UKU6
YFKAYPGYYFTGDGA	ACSS1	521	Q9NUB1
QYPDYGGYHVAAAAA	CDX2	36	Q99626
FYFVAFYYHGDHPVA	C4B	541	P0C0L5
YHPNFRGFDYYFGIP	ARSG	146	Q96EG1
FDRKHYFYADLPAGY	GATB	136	O75879
SDGFAFPHYYIKPYH	ANKRD36B	6	Q8N2N9
YGREFAYGGHPYPFS	DESI2	36	Q9BSY9
YHFTVRAYNGAGYGP	CNTN5	946	O94779
GGHSYFFKGAYYLKL	MMP2	626	P08253
HNVSPGYNFRFAKYY	P2RX4	286	Q99571
APFYPGYTNYGSFGH	IRX5	406	P78411
VYGLLYYAGHGYENF	MALT1	406	Q9UDY8
YYAGHGYENFGNSFM	MALT1	411	Q9UDY8
YAGYNYQAFDIGNHF	ETNK2	271	Q9NVF9
GHYITFDGKYYDFDG	MUC2	866	Q02817
FPYGYHAGFNHGFNC	KDM4A	271	O75164
YYAPGSNYDFFAHGP	LHX5	286	Q9H2C1
VYAAAYPLHDGDYNG	ANO1	276	Q5XXA6
AYFYDPDVGNFHYGA	HDAC3	6	O15379
SFHKYGNYFFPGTGD	HDAC3	191	O15379
YYLHFGSPHKGSYLY	FA2H	316	Q7L5A8
NLDYYVAVYLPGHFF	GSAP	341	A4D1B5
DYFAVGYYGQGFPSF	DOCK2	1341	Q92608
YNYNQHAYPTAYGGK	DMKN	431	Q6E0U4
GDGKKAHQDFGYFYG	UPB1	301	Q9UBR1
YNDYFEYFGPDFKLH	HDAC2	331	Q92769
FYFVAFYYHGDHPVA	C4A	541	P0C0L4
KGYPTFHYYHYGKFA	PDIA5	471	Q14554
YYGAPFEHKGYSNAQ	UVRAG	161	Q9P2Y5
FEGNHYFYSPYPTKT	RPN1	156	P04843
HADLGAGYYRKYFYG	SIPA1	211	Q96FS4
KEFAFYHQGYAAGPY	HOXA13	226	P31271
GVNVSFFHYPEYGYT	TENM3	881	Q9P273
KGAFFNPKYQHEGFY	TRPV3	246	Q8NET8
NHGFPIYTFSKYYFP	TRIM6	451	Q9C030