Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	LIMD1 PABPC1 DAZAP2 CNOT3 EIF4G1	9.46e-06	269	23	5	GO:0036464
GeneOntologyCellularComponent	ribonucleoprotein granule	LIMD1 PABPC1 DAZAP2 CNOT3 EIF4G1	1.29e-05	287	23	5	GO:0035770
GeneOntologyCellularComponent	cytoplasmic stress granule	PABPC1 DAZAP2 EIF4G1	1.56e-04	96	23	3	GO:0010494
GeneOntologyCellularComponent	adherens junction	LIMD1 PLEKHA7 PARD3B	1.57e-03	212	23	3	GO:0005912
GeneOntologyCellularComponent	somatodendritic compartment	VGF SHISA9 PABPC1 PRSS12 IGSF9B MAPK8IP3	1.72e-03	1228	23	6	GO:0036477
GeneOntologyCellularComponent	dendrite	SHISA9 PABPC1 PRSS12 IGSF9B MAPK8IP3	2.09e-03	858	23	5	GO:0030425
GeneOntologyCellularComponent	dendritic tree	SHISA9 PABPC1 PRSS12 IGSF9B MAPK8IP3	2.11e-03	860	23	5	GO:0097447
Domain	IGv	CD28 IGSF9B	3.81e-03	75	23	2	SM00406
Domain	PDZ	PARD3B SYNPO2L	1.29e-02	141	23	2	PF00595
Domain	PDZ	PARD3B SYNPO2L	1.41e-02	148	23	2	SM00228
Domain	-	PARD3B SYNPO2L	1.45e-02	150	23	2	2.30.42.10
Domain	PDZ	PARD3B SYNPO2L	1.47e-02	151	23	2	PS50106
Domain	PDZ	PARD3B SYNPO2L	1.49e-02	152	23	2	IPR001478
Pathway	REACTOME_DEADENYLATION_OF_MRNA	PABPC1 CNOT3 EIF4G1	4.13e-06	24	19	3	MM15090
Pathway	REACTOME_DEADENYLATION_OF_MRNA	PABPC1 CNOT3 EIF4G1	4.69e-06	25	19	3	M13492
Pathway	REACTOME_M_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_MATERNALLY_STORED_FACTORS	PABPC1 CNOT3 EIF4G1	1.10e-05	33	19	3	M48026
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	PABPC1 CNOT3 EIF4G1	4.93e-05	54	19	3	MM15089
Pathway	REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY	PABPC1 CNOT3 EIF4G1	5.50e-05	56	19	3	M839
Pathway	REACTOME_Z_DECAY_DEGRADATION_OF_MATERNAL_MRNAS_BY_ZYGOTICALLY_EXPRESSED_FACTORS	PABPC1 EIF4G1	1.13e-04	12	19	2	M48027
Pathway	BIOCARTA_EIF4_PATHWAY	PABPC1 EIF4G1	4.67e-04	24	19	2	M4791
Pathway	REACTOME_MATERNAL_TO_ZYGOTIC_TRANSITION_MZT	PABPC1 CNOT3 EIF4G1	6.37e-04	128	19	3	M48019
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	LIMD1 WNK1 TET2 PLEKHA7 PABPC1 PARD3B NCOA6 AQR TAB3 EIF4G1	7.02e-11	861	23	10	36931259
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	RNF38 WNK1 PLEKHA7 PABPC1 NCOA6 IGSF9B	2.91e-07	430	23	6	35044719
Pubmed	Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G.	PABPC1 EIF4G1	4.18e-07	2	23	2	29142127
Pubmed	Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells.	PABPC1 EIF4G1	4.18e-07	2	23	2	22431630
Pubmed	Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.	PABPC1 EIF4G1	4.18e-07	2	23	2	12086624
Pubmed	A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding.	PABPC1 EIF4G1	4.18e-07	2	23	2	16772376
Pubmed	Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G.	PABPC1 EIF4G1	4.18e-07	2	23	2	23041282
Pubmed	BRCA1-Dependent Translational Regulation in Breast Cancer Cells.	PABPC1 EIF4G1	1.25e-06	3	23	2	23805307
Pubmed	Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors.	PABPC1 EIF4G1	1.25e-06	3	23	2	15567442
Pubmed	Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.	PABPC1 EIF4G1	1.25e-06	3	23	2	18799579
Pubmed	A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.	PABPC1 EIF4G1	1.25e-06	3	23	2	9857202
Pubmed	DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs.	PABPC1 EIF4G1	2.51e-06	4	23	2	22872150
Pubmed	Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay.	PABPC1 EIF4G1	2.51e-06	4	23	2	16556936
Pubmed	Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.	PABPC1 EIF4G1	2.51e-06	4	23	2	18490513
Pubmed	Proline-rich transcript in brain protein induces stress granule formation.	DAZAP2 EIF4G1	2.51e-06	4	23	2	17984221
Pubmed	Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.	CD28 PARD3B	4.18e-06	5	23	2	15210771
Pubmed	HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.	PABPC1 EIF4G1	4.18e-06	5	23	2	19956697
Pubmed	eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells.	PABPC1 EIF4G1	8.77e-06	7	23	2	23665581
Pubmed	Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.	PABPC1 EIF4G1	8.77e-06	7	23	2	10205060
Pubmed	Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.	PLEKHA7 PABPC1	8.77e-06	7	23	2	28877994
Pubmed	NEDDylation promotes stress granule assembly.	PABPC1 EIF4G1	1.88e-05	10	23	2	27381497
Pubmed	The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.	PABPC1 EIF4G1	1.88e-05	10	23	2	23788676
Pubmed	miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.	PABPC1 CNOT3	1.88e-05	10	23	2	21984185
Pubmed	UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.	PABPC1 EIF4G1	1.88e-05	10	23	2	31114027
Pubmed	miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.	PABPC1 CNOT3	2.29e-05	11	23	2	21984184
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	TET2 PABPC1 AQR TAB3 EIF4G1	2.60e-05	551	23	5	34728620
Pubmed	Human transcription factor protein interaction networks.	LIMD1 TET2 PABPC1 NCOA6 CNOT3 TAB3 EIF4G1	2.67e-05	1429	23	7	35140242
Pubmed	G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.	PABPC1 EIF4G1	2.75e-05	12	23	2	27022092
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	PABPC1 EIF4G1	3.79e-05	14	23	2	19716330
Pubmed	Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.	RNF38 AQR SYNPO2L EIF4G1	3.80e-05	292	23	4	12819125
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	PABPC1 CNOT3	4.37e-05	15	23	2	21981923
Pubmed	Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.	PABPC1 EIF4G1	1.14e-04	24	23	2	25157170
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	LIMD1 WNK1 PABPC1 CAPNS1	1.27e-04	399	23	4	35987950
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TET2 TAB3 EYA1	1.36e-04	152	23	3	38360978
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RNF38 TET2 DAZAP2 CNOT3 MAPK8IP3 EIF4G1	1.48e-04	1285	23	6	35914814
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	PARD3B SYNPO2L	2.46e-04	35	23	2	33864728
Pubmed	14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.	WNK1 PLEKHA7	3.54e-04	42	23	2	23444366
Pubmed	Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.	PABPC1 CNOT3	4.07e-04	45	23	2	23663784
Pubmed	Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.	PABPC1 EIF4G1	4.83e-04	49	23	2	24248602
Pubmed	Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.	PABPC1 EIF4G1	5.44e-04	52	23	2	26265008
Pubmed	Functional proteomics mapping of a human signaling pathway.	LIMD1 DAZAP2 NCOA6 EIF4G1	5.65e-04	591	23	4	15231748
Pubmed	The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation.	PABPC1 IGSF9B	6.08e-04	55	23	2	31640799
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	WNK1 PABPC1 PARD3B	6.19e-04	255	23	3	15324660
Interaction	YWHAG interactions	LIMD1 WNK1 TET2 PLEKHA7 PABPC1 PARD3B NCOA6 AQR TAB3 CAPNS1 EIF4G1	3.33e-08	1248	23	11	int:YWHAG
Interaction	YWHAH interactions	LIMD1 WNK1 TET2 PLEKHA7 PARD3B NCOA6 AQR TAB3 CAPNS1 EIF4G1	1.37e-07	1102	23	10	int:YWHAH
Interaction	SFN interactions	WNK1 TET2 PLEKHA7 PABPC1 PARD3B NCOA6 TAB3 EIF4G1	5.76e-07	692	23	8	int:SFN
Interaction	YWHAQ interactions	WNK1 TET2 PLEKHA7 PARD3B NCOA6 TAB3 CAPNS1 EIF4G1	2.03e-05	1118	23	8	int:YWHAQ
Cytoband	Ensembl 112 genes in cytogenetic band chr2q33	CD28 PARD3B	4.72e-03	205	23	2	chr2q33
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	SHISA9 MAPK8IP3	1.91e-02	426	23	2	chr16p13
GeneFamily	PDZ domain containing	PARD3B SYNPO2L	1.09e-02	152	19	2	1220
GeneFamily	Adenosine receptors\|V-set domain containing	CD28 IGSF9B	1.25e-02	163	19	2	590
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	LIMD1 WNK1 PABPC1 CAPNS1	2.90e-06	196	23	4	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	WNK1 PLEKHA7 CD28 PARD3B	3.02e-06	198	23	4	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SHISA9 PLEKHA7 ADAMTSL2	5.54e-05	145	23	3	b17699f7f98d2361a4d26c26f52db05e7ff69dff
ToppCell	COVID-19_Moderate-MAIT\|World / disease group, cell group and cell class	PLEKHA7 CD28 IGSF9B	7.42e-05	160	23	3	bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SHISA9 IGSF9B EYA1	8.42e-05	167	23	3	49b19159c62d33d65ed1e59a148c11ae902fd41c
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SHISA9 IGSF9B EYA1	1.00e-04	177	23	3	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	normal-na-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PABPC1 PRSS12 CD28	1.02e-04	178	23	3	fa3585383a1e7da460c88a802aaa81246d681b6b
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SHISA9 IGSF9B EYA1	1.10e-04	183	23	3	e0854864d377e158a4793088d1cb6b3dbf2c805d
ToppCell	10x5'v1-week_17-19-Lymphocytic_T-T_NK-Treg\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CD28 NCOA6 IGSF9B	1.10e-04	183	23	3	5fb933acfe6bc555c90dba71e75d4be658763945
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SHISA9 IGSF9B EYA1	1.14e-04	185	23	3	56c7a0dbf141728ac76b8c90af197719942ca67c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHISA9 PARD3B EYA1	1.20e-04	188	23	3	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	LIMD1 PRSS12 PARD3B	1.23e-04	190	23	3	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PABPC1 CAPNS1 EIF4G1	1.35e-04	196	23	3	28e9e191361966df3a9bd48450090577aa72a999
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_2\|COVID-19_Convalescent / Disease condition and Cell class	PABPC1 DAZAP2 CAPNS1	1.39e-04	198	23	3	f65fd9b773aeafa55e38309479954a8e41371f52
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PLEKHA7 PRSS12 EYA1	1.39e-04	198	23	3	1408e02e053ad3406229bfe8189da03be6366e81
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PLEKHA7 PRSS12 EYA1	1.39e-04	198	23	3	af399569c718f5fd971d73a7926768c9311002a3
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	PABPC1 DAZAP2 CAPNS1	1.41e-04	199	23	3	3feee9f53860b4b2e93ff2360beb2b2b74f51d24
ToppCell	Neuronal-Inhibitory-iB-iB_1(GAD1)-GLP1R--L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	VGF PLEKHA7 PARD3B	1.44e-04	200	23	3	cdc43730334f8f623d936469acbae00a67c13a7b
ToppCell	Neuronal-Inhibitory-iB-iB_1(GAD1)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	VGF PLEKHA7 PARD3B	1.44e-04	200	23	3	6c16151567ef100296f7c12cde350fc6ce146745
ToppCell	Neuronal-Inhibitory-iB-iB_1(GAD1)-GLP1R-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	VGF PLEKHA7 PARD3B	1.44e-04	200	23	3	6b1c0176fe2ec6baedae44a7b330c2b32eea25cb
ToppCell	H1299\|World / Cell line, Condition and Strain	VGF WNK1 PABPC1	1.44e-04	200	23	3	23f08d7cffacfced48785cd3ad230ecadb95713f
ToppCell	Neuronal-Inhibitory-iB-iB_1(GAD1)-GLP1R\|Neuronal / cells hierarchy compared to all cells using T-Statistic	VGF PLEKHA7 PARD3B	1.44e-04	200	23	3	7da0ccfcd024842ad85f34b523ead6ec61f7e864
Disease	Peripheral T-Cell Lymphoma	TET2 CD28	2.61e-05	10	23	2	C0079774
Disease	Sezary Syndrome	TET2 CD28	2.02e-04	27	23	2	C0036920
Disease	cortical surface area measurement	TET2 PLEKHA7 PRSS12 CD28 PARD3B EYA1	4.58e-04	1345	23	6	EFO_0010736
Disease	autism	PARD3B EYA1	6.41e-04	48	23	2	EFO_0003758
Disease	calcium measurement	TET2 PABPC1 NCOA6 EYA1	1.30e-03	628	23	4	EFO_0004838
Disease	rheumatoid arthritis (is_marker_for)	CD28 TAB3	1.32e-03	69	23	2	DOID:7148 (is_marker_for)
Disease	vitamin D measurement	VGF PLEKHA7 CNOT3	2.19e-03	336	23	3	EFO_0004631
Disease	hypertrophic cardiomyopathy	PARD3B SYNPO2L	2.33e-03	92	23	2	EFO_0000538
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	SHISA9 TET2 IGSF9B	3.53e-03	398	23	3	EFO_0003756, EFO_0003888, EFO_0004337
Disease	melanoma	TET2 NCOA6	4.32e-03	126	23	2	EFO_0000756
Disease	sleep measurement	TET2 EYA1	4.94e-03	135	23	2	EFO_0004870

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRRPGPTRKHYQPYA	CD28	196	P10747
PHVIPNRGPYPYNQP	AQR	781	O60306
QYLPRNPCPTPPYHH	CNOT3	636	O75175
AYYPPSQIAQLRPSP	PABPC1	421	P11940
DLRYPQHYPPPPAPQ	PARD3B	1136	Q8TEW8
PVYPQTLHLPQAPPY	DAZAP2	21	Q15038
PHYPYYLPTQQRPPR	PRSS12	41	P56730
PPPAKRPYPSVNIHY	MAPK8IP3	586	Q9UPT6
PYPPQEQRSRPYLHG	LIMD1	126	Q9UGP4
PRPTHQFSPPQIYPS	EYA1	76	Q99502
QFSPPQIYPSNRPYP	EYA1	81	Q99502
QIYPSNRPYPHILPT	EYA1	86	Q99502
LQPPHESRPQPIYYG	ADAMTSL2	331	Q86TH1
TPNRASPRPYYPQTP	NCOA6	1211	Q14686
YNPEPPPPRTHYSNI	CAPNS1	76	P04632
QPRQHFYPSRAQPPS	EIF4G1	46	Q04637
YSPNIRAPPPIAYNP	SYNPO2L	801	Q9H987
SRYRSQQPIPPPPYH	RNF38	371	Q9H0F5
GPYHPFPNYIRPRTL	VGF	541	O15240
GPVPHYSQRPLPVYP	TAB3	256	Q8N5C8
LFPQLQTYVPYRPHP	PLEKHA7	881	Q6IQ23
QTYVPYRPHPPQLRK	PLEKHA7	886	Q6IQ23
GTRPQHYPPPQPYFI	SHISA9	401	B4DS77
SYLPPPAYSPRFQPR	IGSF9B	921	Q9UPX0
VLYQGFPPRLPPQYP	WNK1	941	Q9H4A3
TNPYMRRPNPVSPYP	TET2	1566	Q6N021