Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404	3.31e-06	1412	30	11	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404	3.26e-05	1459	30	10	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714	5.95e-05	1244	30	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714	7.03e-05	1271	30	9	GO:0000987
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	ZNF729 AKAP6 SMARCC1 ZNF208 SCRIB ZNF107 MPP7	1.37e-03	1160	30	7	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	ZNF729 AKAP6 SMARCC1 ZNF208 SCRIB ZNF107 MPP7	3.34e-03	1356	30	7	GO:0060090
GeneOntologyMolecularFunction	protein kinase A binding	AKAP6 NBEA	3.42e-03	58	30	2	GO:0051018
GeneOntologyBiologicalProcess	protein localization to adherens junction	SCRIB MPP7	3.06e-05	6	30	2	GO:0071896
GeneOntologyBiologicalProcess	transposable element silencing	ZNF729 ZNF208 ZNF107	4.04e-05	46	30	3	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF729 ZNF208 ZNF107	4.59e-05	48	30	3	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF729 ZNF208 ZNF107	5.20e-05	50	30	3	GO:0032196
Domain	-	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	3.62e-10	679	31	12	3.30.160.60
Domain	zf-C2H2	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	4.57e-10	693	31	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	4.65e-10	694	31	12	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	1.63e-09	775	31	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	1.68e-09	777	31	12	PS00028
Domain	Znf_C2H2-like	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	2.21e-09	796	31	12	IPR015880
Domain	Znf_C2H2	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	2.51e-09	805	31	12	IPR007087
Domain	ZnF_C2H2	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	2.62e-09	808	31	12	SM00355
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2	1.65e-08	4	31	3	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	1.65e-08	4	31	3	PF14914
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	1.65e-08	4	31	3	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2	1.65e-08	4	31	3	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2	1.65e-08	4	31	3	IPR015753
Domain	zf-C2H2_6	ZNF729 ZNF208 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404	3.29e-08	314	31	8	PF13912
Domain	KRAB	ZNF729 ZNF708 ZNF208 ZNF789 ZNF732 ZNF273 ZNF714 ZNF404	9.05e-08	358	31	8	PS50805
Domain	KRAB	ZNF729 ZNF708 ZNF208 ZNF789 ZNF732 ZNF273 ZNF714 ZNF404	1.14e-07	369	31	8	SM00349
Domain	KRAB	ZNF729 ZNF708 ZNF208 ZNF789 ZNF732 ZNF273 ZNF714 ZNF404	1.17e-07	370	31	8	IPR001909
Domain	KRAB	ZNF729 ZNF708 ZNF208 ZNF789 ZNF732 ZNF273 ZNF404	1.59e-06	358	31	7	PF01352
Domain	LRR_8	SCRIB LRRC37A LRRC37A3 LRRC37A2	1.76e-04	171	31	4	PF13855
Domain	Leu-rich_rpt_typical-subtyp	SCRIB LRRC37A LRRC37A3 LRRC37A2	2.01e-04	177	31	4	IPR003591
Domain	LRR_TYP	SCRIB LRRC37A LRRC37A3 LRRC37A2	2.01e-04	177	31	4	SM00369
Domain	LRR	SCRIB LRRC37A LRRC37A3 LRRC37A2	3.26e-04	201	31	4	PS51450
Domain	LRR_1	SCRIB LRRC37A LRRC37A3 LRRC37A2	4.51e-04	219	31	4	PF00560
Domain	Leu-rich_rpt	SCRIB LRRC37A LRRC37A3 LRRC37A2	1.00e-03	271	31	4	IPR001611
Domain	-	SCRIB LRRC37A LRRC37A3 LRRC37A2	1.87e-03	321	31	4	3.80.10.10
Domain	L_dom-like	SCRIB LRRC37A LRRC37A3 LRRC37A2	2.02e-03	328	31	4	IPR032675
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	3.11e-09	4	33	3	22419166
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF208 ZNF107	9.30e-08	10	33	3	18588511
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2	9.30e-08	10	33	3	23064749
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF208 ZNF107	1.28e-07	11	33	3	15469996
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF208 ZNF107	2.21e-07	13	33	3	19850934
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF208 ZNF107	3.51e-07	15	33	3	15885501
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	RLF SMARCC1 DNMT1	6.29e-07	18	33	3	24025402
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF708 ZNF208 ZNF789 ZNF107 ZNF273	7.62e-07	181	33	5	37372979
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF208 ZNF107	2.80e-06	29	33	3	14563677
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF208 ZNF107	1.39e-05	49	33	3	9630514
Pubmed	BRIT1/MCPH1 links chromatin remodelling to DNA damage response.	SMARCC1 MCM2	1.83e-05	7	33	2	19525936
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF729 SMARCC1 MCM2 ZNF107 ZNF714	6.31e-05	451	33	5	36168627
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF208 ZNF107	1.04e-04	16	33	2	8467795
Pubmed	E2F6 associates with BRG1 in transcriptional regulation.	SMARCC1 DNMT1	1.18e-04	17	33	2	23082233
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	SMARCC1 DNMT1	1.32e-04	18	33	2	28068325
Pubmed	Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.	SMARCC1 MCM2	1.48e-04	19	33	2	35173232
Pubmed	DNA Methylation-Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-Cell Heterogeneity.	MCM2 DNMT1	2.58e-04	25	33	2	36607262
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	SMARCC1 MCM2	3.99e-04	31	33	2	23602572
Pubmed	Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation.	SMARCC1 DNMT1	5.69e-04	37	33	2	24335282
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	SMARCC1 MCM2 DNMT1	6.85e-04	182	33	3	26527279
Pubmed	Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.	NBEA SCRIB	7.00e-04	41	33	2	34638806
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	SMARCC1 MCM2	7.34e-04	42	33	2	16387653
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCC1 MCM2 SCRIB DNMT1 ZFP91	7.63e-04	774	33	5	15302935
Interaction	LTBP2 interactions	ZNF708 ZNF664 ZNF107 ZNF273 ZNF714	1.85e-07	85	31	5	int:LTBP2
Interaction	TRIM28 interactions	SMARCC1 ZNF708 MCM2 ZNF208 SCRIB ZNF789 ZNF107 ZNF732 ZNF273 DNMT1	4.53e-05	1474	31	10	int:TRIM28
Interaction	ANOS1 interactions	ZNF708 ZNF107 ZNF273 ZFP91	6.59e-05	143	31	4	int:ANOS1
Cytoband	19p12	ZNF729 ZNF708 ZNF208 ZNF714	5.41e-07	90	33	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF708 ZNF208 ZNF714	1.83e-06	122	33	4	chr19p12
Cytoband	17q21.31	LRRC37A LRRC37A2	1.61e-03	82	33	2	17q21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q33	FAXDC2 C5orf52	3.28e-03	118	33	2	chr5q33
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	CFAP95 GNAQ	9.04e-03	199	33	2	chr9q21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 RLF ZNF708 ZNF208 ZNF664 ZNF789 ZNF107 ZNF732 ZNF273 ZNF714 ZNF404 ZFP91	1.27e-11	718	23	12	28
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP6 NBEA	6.15e-04	29	23	2	396
GeneFamily	PDZ domain containing	SCRIB MPP7	1.58e-02	152	23	2	1220
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-LMPP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZNF208 ZNF789 LRRC37A3 TMPRSS3	9.67e-06	182	33	4	69b5cae6fe3bbb0fc60bd2f71b6cfa6cbb0b00ee
ToppCell	B_cell_maturation-CD34+_pro-B\|B_cell_maturation / Lineage and Cell class	CYGB MCM2 GNAQ DNMT1	1.35e-05	198	33	4	5737606e5e3dc56f11fdf70166caf4ba4a81bc9d
Disease	mammographic density percentage	NBEA GVINP1	4.83e-04	29	33	2	EFO_0006502
Disease	liver cirrhosis (biomarker_via_orthology)	CYGB DNMT1	6.65e-04	34	33	2	DOID:5082 (biomarker_via_orthology)
Disease	mammographic density measurement	NBEA GVINP1	1.44e-03	50	33	2	EFO_0005941
Disease	creatine kinase measurement	AKAP6 NEB	1.99e-03	59	33	2	EFO_0004534
Disease	pancreatic ductal carcinoma (is_marker_for)	DNMT1 TMPRSS3	2.13e-03	61	33	2	DOID:3587 (is_marker_for)
Disease	Mammary Neoplasms, Human	LRRC37A ZNF404 DNMT1 LRRC37A2	2.69e-03	525	33	4	C1257931
Disease	Mammary Carcinoma, Human	LRRC37A ZNF404 DNMT1 LRRC37A2	2.69e-03	525	33	4	C4704874
Disease	Mammary Neoplasms	LRRC37A ZNF404 DNMT1 LRRC37A2	2.73e-03	527	33	4	C1458155
Disease	Breast Carcinoma	LRRC37A ZNF404 DNMT1 LRRC37A2	2.94e-03	538	33	4	C0678222
Disease	post-traumatic stress disorder symptom measurement	NBEA LRRC37A2	3.81e-03	82	33	2	EFO_0008535
Disease	cleft lip	AKAP6 GVINP1 ZNF404	3.89e-03	284	33	3	EFO_0003959
Disease	hearing impairment	DNMT1 TMPRSS3	5.39e-03	98	33	2	C1384666
Disease	sleep duration, triglyceride measurement	ZNF664 ZNF273	6.05e-03	104	33	2	EFO_0004530, EFO_0005271
Disease	Malignant neoplasm of breast	AKAP6 LRRC37A ZNF404 DNMT1 LRRC37A2	6.44e-03	1074	33	5	C0006142
Disease	Abnormality of refraction	AKAP6 NBEA GNAQ ZNF664	6.49e-03	673	33	4	HP_0000539
Disease	Adenocarcinoma	SMARCC1 DNMT1	7.47e-03	116	33	2	C0001418
Disease	Carcinoma, Granular Cell	SMARCC1 DNMT1	7.47e-03	116	33	2	C0205644
Disease	Adenocarcinoma, Tubular	SMARCC1 DNMT1	7.47e-03	116	33	2	C0205645
Disease	Adenocarcinoma, Oxyphilic	SMARCC1 DNMT1	7.47e-03	116	33	2	C0205642
Disease	Carcinoma, Cribriform	SMARCC1 DNMT1	7.47e-03	116	33	2	C0205643
Disease	Adenocarcinoma, Basal Cell	SMARCC1 DNMT1	7.47e-03	116	33	2	C0205641

Protein segments in the cluster

Peptide	Gene	Start	Entry
SYIHSKVKVIYKAPS	DNMT1	826	P26358
YDKHIKVNKKYNHIP	GVINP1	1946	Q7Z2Y8
LEKTKKKISHYYEHL	C5orf52	111	A6NGY3
TLKIPYKYEHNKAHA	GNAQ	96	P50148
KKYIIYAKERVHPKL	MCM2	721	P49736
RSHHKKYSKPVLVYS	CFAP95	36	Q5VTT2
KPIVHSRKKYRFHKT	LRRC37A3	1296	O60309
KPIVHARKKYRFHKT	LRRC37A2	1296	A6NM11
KPIVHARKKYRFHKT	LRRC37A	1296	A6NMS7
PNSKKKEHRKFYTIH	ARNTL2	301	Q8WYA1
VKIHEKLHYYEKQSP	MPP7	51	Q5T2T1
QYTHKIYHLKSKVPA	PITPNB	56	P48739
RLLHHPTFYKKIHKK	FAXDC2	191	Q96IV6
KAHALKHKVEPVYFK	CYGB	111	Q8WWM9
FQKTPHYSKLHLKTK	SLC15A2	446	Q16348
VTEKIYYLKLHEKHP	GARIN1A	146	Q6NXP2
HSKVTYEAHKEYLAK	NBEA	946	Q8NFP9
DTPHYKKHFKISKLP	SCRIB	606	Q14160
KHYKKYVHADAPTNK	SMARCC1	61	Q92922
SDSEIYPTYHVKKKH	AKAP6	676	Q13023
LVEKIVYHSKYKPKR	TMPRSS3	286	P57727
HKKIHTGEKPYKCEY	ZNF107	766	Q9UII5
TLTKHKRIYTKEKPY	ZNF273	416	Q14593
LTTHKFIHVKEKPYK	ZNF714	271	Q96N38
RKVHPYHFKPKKIKT	RLF	976	Q13129
LYQHKKIHSGEKPYK	ZNF404	286	Q494X3
TLTYHKVIHTGKKPY	ZNF708	406	P17019
YHKKIHTGEKPYKCE	ZNF208	386	O43345
YHKKIHTVEKPYKCE	ZNF208	766	O43345
LSYHKKIHTGEKPYK	ZNF208	876	O43345
SYHKKIHTEEKPYKY	ZNF208	961	O43345
LSYHKKIHTVEKPYK	ZNF208	1156	O43345
TLRYHKKIHTGEKPY	ZNF208	1211	O43345
RHKKIHTVEKPYKCY	ZNF664	76	Q8N3J9
HIKYQHLLKKKYVCP	ZFP91	331	Q96JP5
YLSKHKKIHTGEKPY	ZNF732	516	B4DXR9
YLVEHKRIHTKEKPY	ZNF789	271	Q5FWF6
HKIIHTEDKPYKYKK	ZNF729	226	A6NN14
KDHTYKVHPDKTKFT	NEB	736	P20929
YRELYHKLKDKIHTT	NEB	5021	P20929