Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	FMO4 CYP26B1 KDM4E TET1 KDM1B FTO CMAHP CYP4F11	4.06e-05	194	130	8	GO:0016705
GeneOntologyMolecularFunction	2,4-dienoyl-CoA reductase (NADPH) activity	PECR DECR1	1.26e-04	3	130	2	GO:0008670
GeneOntologyMolecularFunction	epidermal growth factor receptor activity	ERBB4 EGFR	2.50e-04	4	130	2	GO:0005006
GeneOntologyMolecularFunction	translation elongation factor activity	EEF1A1 EEF1A1P5 EEF1A2	2.83e-04	20	130	3	GO:0003746
GeneOntologyMolecularFunction	amino acid:monoatomic cation antiporter activity	SLC38A5 SLC25A13	4.15e-04	5	130	2	GO:0140848
GeneOntologyMolecularFunction	oxidoreductase activity	PECR FMO4 CYP26B1 COX15 RRM1 KDM4E NDUFB3 PGK1 DECR1 TET1 KDM1B FTO CMAHP CYP4F11	4.74e-04	766	130	14	GO:0016491
GeneOntologyBiologicalProcess	cellular response to epidermal growth factor stimulus	ERBB2 ERBB4 EEF1A1 EGFR BAIAP2	1.35e-05	49	129	5	GO:0071364
GeneOntologyBiologicalProcess	response to epidermal growth factor	ERBB2 ERBB4 EEF1A1 EGFR BAIAP2	2.19e-05	54	129	5	GO:0070849
GeneOntologyBiologicalProcess	positive regulation of kinase activity	ERBB2 RELN ERBB4 ANGPT1 ERN1 ALS2 TNFRSF10A CHRNA3 EEF1A2 TNFSF11 EGFR	4.89e-05	405	129	11	GO:0033674
GeneOntologyCellularComponent	RAVE complex	DMXL2 DMXL1	1.16e-04	3	131	2	GO:0043291
GeneOntologyCellularComponent	eukaryotic translation elongation factor 1 complex	EEF1A1 EEF1A2	2.32e-04	4	131	2	GO:0005853
Domain	Tyr_kinase_EGF/ERB/XmrK_rcpt	ERBB2 ERBB4 EGFR	1.19e-06	4	126	3	IPR016245
Domain	GF_recep_IV	ERBB2 ERBB4 EGFR	5.91e-06	6	126	3	PF14843
Domain	GF_recep_IV	ERBB2 ERBB4 EGFR	5.91e-06	6	126	3	IPR032778
Domain	Recep_L_domain	ERBB2 ERBB4 EGFR	1.03e-05	7	126	3	PF01030
Domain	Furin-like	ERBB2 ERBB4 EGFR	1.03e-05	7	126	3	PF00757
Domain	Rcpt_L-dom	ERBB2 ERBB4 EGFR	1.03e-05	7	126	3	IPR000494
Domain	Furin-like_Cys-rich_dom	ERBB2 ERBB4 EGFR	1.03e-05	7	126	3	IPR006211
Domain	-	ERBB2 ERBB4 EGFR	1.03e-05	7	126	3	3.80.20.20
Domain	Transl_elong_EF1A_euk/arc	EEF1A1 EEF1A2	4.52e-05	2	126	2	IPR004539
Domain	Rav1p_C	DMXL2 DMXL1	4.52e-05	2	126	2	IPR022033
Domain	Rav1p_C	DMXL2 DMXL1	4.52e-05	2	126	2	PF12234
Domain	Noelin-1	OLFM3 OLFM2	1.35e-04	3	126	2	PF12308
Domain	Noelin_dom	OLFM3 OLFM2	1.35e-04	3	126	2	IPR022082
Domain	Furin_repeat	ERBB2 ERBB4 EGFR	2.27e-04	18	126	3	IPR006212
Domain	FU	ERBB2 ERBB4 EGFR	2.27e-04	18	126	3	SM00261
Domain	RCC1	ALS2 RCC1 SERGEF	3.14e-04	20	126	3	PF00415
Domain	RCC1_1	ALS2 RCC1 SERGEF	3.65e-04	21	126	3	PS00625
Domain	RCC1_2	ALS2 RCC1 SERGEF	3.65e-04	21	126	3	PS00626
Domain	RCC1_3	ALS2 RCC1 SERGEF	3.65e-04	21	126	3	PS50012
Domain	-	ALS2 RCC1 SERGEF	4.20e-04	22	126	3	2.130.10.30
Domain	Reg_chr_condens	ALS2 RCC1 SERGEF	4.20e-04	22	126	3	IPR000408
Domain	-	SLC25A14 SLC25A30 SLC25A3 SLC25A13	4.48e-04	53	126	4	1.50.40.10
Domain	Mito_carr	SLC25A14 SLC25A30 SLC25A3 SLC25A13	4.48e-04	53	126	4	PF00153
Domain	SOLCAR	SLC25A14 SLC25A30 SLC25A3 SLC25A13	4.48e-04	53	126	4	PS50920
Domain	Mitochondrial_sb/sol_carrier	SLC25A14 SLC25A30 SLC25A3 SLC25A13	4.48e-04	53	126	4	IPR018108
Domain	Mt_carrier_dom	SLC25A14 SLC25A30 SLC25A3 SLC25A13	4.48e-04	53	126	4	IPR023395
Domain	RCC1/BLIP-II	ALS2 RCC1 SERGEF	4.81e-04	23	126	3	IPR009091
Domain	Gphrmn_rcpt_fam	LGR4 LGR6	6.65e-04	6	126	2	IPR002131
Domain	Transl_B-barrel	RPL35A EEF1A1 EEF1A2	7.79e-04	27	126	3	IPR009000
Domain	Transl_elong_EFTu/EF1A_C	EEF1A1 EEF1A2	1.23e-03	8	126	2	IPR004160
Domain	GTP_EFTU_D3	EEF1A1 EEF1A2	1.23e-03	8	126	2	PF03143
Domain	G_TR_CS	EEF1A1 EEF1A2	1.58e-03	9	126	2	IPR031157
Domain	Pkinase_Tyr	ERBB2 ERBB4 TEX14 ZAP70 EGFR	1.82e-03	129	126	5	PF07714
Domain	Transl_elong_EF1A/Init_IF2_C	EEF1A1 EEF1A2	1.96e-03	10	126	2	IPR009001
Domain	IL-1_rcpt_fam	IL1RAPL1 IL1RAPL2	2.39e-03	11	126	2	IPR015621
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB2 ERBB4 TEX14 ZAP70 EGFR	2.45e-03	138	126	5	IPR001245
Domain	Mit_uncoupling	SLC25A14 SLC25A30	2.85e-03	12	126	2	IPR002030
Domain	Tyr_kinase_cat_dom	ERBB2 ERBB4 ZAP70 EGFR	2.98e-03	88	126	4	IPR020635
Domain	TyrKc	ERBB2 ERBB4 ZAP70 EGFR	2.98e-03	88	126	4	SM00219
Domain	G_TR_1	EEF1A1 EEF1A2	3.35e-03	13	126	2	PS00301
Domain	OLF	OLFM3 OLFM2	3.35e-03	13	126	2	PF02191
Domain	OLF	OLFM3 OLFM2	3.35e-03	13	126	2	PS51132
Domain	Olfac-like_dom	OLFM3 OLFM2	3.35e-03	13	126	2	IPR003112
Domain	OLF	OLFM3 OLFM2	3.35e-03	13	126	2	SM00284
Domain	TF_fork_head_CS_2	FOXD4L1 FOXG1 FOXC2	3.68e-03	46	126	3	IPR030456
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH7	3.90e-03	14	126	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH7	3.90e-03	14	126	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH7	3.90e-03	14	126	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH7	3.90e-03	14	126	2	PF08393
Domain	MORN	ALS2 ANKMY1	3.90e-03	14	126	2	SM00698
Domain	MT	DNAH3 DNAH7	3.90e-03	14	126	2	PF12777
Domain	AAA_8	DNAH3 DNAH7	3.90e-03	14	126	2	PF12780
Domain	TF_fork_head_CS_1	FOXD4L1 FOXG1 FOXC2	3.92e-03	47	126	3	IPR018122
Domain	PROTEIN_KINASE_TYR	ERBB2 ERBB4 ZAP70 EGFR	4.22e-03	97	126	4	PS00109
Domain	Tyr_kinase_AS	ERBB2 ERBB4 ZAP70 EGFR	4.22e-03	97	126	4	IPR008266
Domain	FH	FOXD4L1 FOXG1 FOXC2	4.41e-03	49	126	3	SM00339
Domain	FORK_HEAD_1	FOXD4L1 FOXG1 FOXC2	4.41e-03	49	126	3	PS00657
Domain	FORK_HEAD_2	FOXD4L1 FOXG1 FOXC2	4.41e-03	49	126	3	PS00658
Domain	Fork_head_dom	FOXD4L1 FOXG1 FOXC2	4.41e-03	49	126	3	IPR001766
Domain	FORK_HEAD_3	FOXD4L1 FOXG1 FOXC2	4.41e-03	49	126	3	PS50039
Domain	Forkhead	FOXD4L1 FOXG1 FOXC2	4.41e-03	49	126	3	PF00250
Domain	DHC_fam	DNAH3 DNAH7	4.48e-03	15	126	2	IPR026983
Domain	MORN	ALS2 ANKMY1	4.48e-03	15	126	2	IPR003409
Domain	Dynein_heavy	DNAH3 DNAH7	4.48e-03	15	126	2	PF03028
Domain	MORN	ALS2 ANKMY1	4.48e-03	15	126	2	PF02493
Domain	Dynein_heavy_dom	DNAH3 DNAH7	4.48e-03	15	126	2	IPR004273
Domain	EFTu-like_2	EEF1A1 EEF1A2	6.44e-03	18	126	2	IPR004161
Domain	GTP_EFTU_D2	EEF1A1 EEF1A2	6.44e-03	18	126	2	PF03144
Domain	G_TR_2	EEF1A1 EEF1A2	6.44e-03	18	126	2	PS51722
Pathway	REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB4 EGFR PRKCA	1.19e-05	22	93	4	M26929
Pathway	REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING	ERBB2 ERBB4 EGFR	4.41e-05	11	93	3	MM15478
Pathway	WP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4	ERBB2 ERBB4 TNFSF11 EGFR	6.27e-05	33	93	4	M39455
Pathway	REACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING	ERBB2 ERBB4 EGFR	7.58e-05	13	93	3	M27729
Pathway	REACTOME_ERBB2_REGULATES_CELL_MOTILITY	ERBB2 ERBB4 EGFR	7.58e-05	13	93	3	MM15320
Pathway	REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB4 EGFR	9.60e-05	14	93	3	MM14761
Pathway	REACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB4 EGFR	9.60e-05	14	93	3	MM14531
Pathway	PID_ERBB_NETWORK_PATHWAY	ERBB2 ERBB4 EGFR	1.19e-04	15	93	3	M201
Pathway	REACTOME_ERBB2_REGULATES_CELL_MOTILITY	ERBB2 ERBB4 EGFR	1.19e-04	15	93	3	M27608
Pathway	REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB4 EGFR	1.46e-04	16	93	3	M562
Pathway	REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING	ERBB2 ERBB4 EGFR	1.46e-04	16	93	3	M570
Pathway	WP_ERBB_SIGNALING_PATHWAY	ERBB2 ERBB4 EGFR PRKCA	2.34e-04	46	93	4	MM15950
Pathway	REACTOME_SIGNALING_BY_ERBB2	ERBB2 ERBB4 EGFR PRKCA	3.24e-04	50	93	4	M553
Pathway	BIOCARTA_HER2_PATHWAY	ERBB2 ERBB4 EGFR	4.47e-04	23	93	3	MM1480
Pathway	BIOCARTA_HER2_PATHWAY	ERBB2 ERBB4 EGFR	4.47e-04	23	93	3	M18719
Pubmed	Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.	ERBB2 ERBB4 EGFR	5.34e-08	3	132	3	15026342
Pubmed	Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells.	ERBB2 ERBB4 EGFR	5.34e-08	3	132	3	12532415
Pubmed	ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.	ERBB2 ERBB4 EGFR	5.34e-08	3	132	3	19370475
Pubmed	Absence of EGFR, ERBB2 and ERBB4 mutation homologous to the oncogenic ERBB3 Val-104 mutation in colorectal cancers.	ERBB2 ERBB4 EGFR	5.34e-08	3	132	3	24862237
Pubmed	Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis.	ERBB2 ERBB4 EGFR	5.34e-08	3	132	3	23100016
Pubmed	Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.	ERBB2 ERBB4 EGFR	5.34e-08	3	132	3	25468910
Pubmed	Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	24557338
Pubmed	Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	23991224
Pubmed	Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	22327010
Pubmed	Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	17177598
Pubmed	The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	36411648
Pubmed	HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	21203579
Pubmed	ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	19263517
Pubmed	Analysis of ErbB receptors in pulmonary carcinoid tumors.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	19447869
Pubmed	Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	18985033
Pubmed	Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	9556621
Pubmed	Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	20204273
Pubmed	WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	12807903
Pubmed	HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	27069134
Pubmed	Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	26021752
Pubmed	The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	16685269
Pubmed	The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	15345710
Pubmed	Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	12621152
Pubmed	Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	22854050
Pubmed	The erbB/HER type 1 tyrosine kinase receptor family.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	9771475
Pubmed	Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	15733067
Pubmed	A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.	ERBB2 ERBB4 EGFR	2.13e-07	4	132	3	8816440
Pubmed	Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	10572067
Pubmed	Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	15682390
Pubmed	Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	25416285
Pubmed	Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	15254894
Pubmed	Expression of epidermal growth factors and a tight junction protein in the nasal mucosa of patients with chronic hypertrophic rhinitis.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	23137868
Pubmed	Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	22554477
Pubmed	Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	15524405
Pubmed	Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	12646923
Pubmed	Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	26886748
Pubmed	Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.	ERBB2 ERBB4 EGFR	5.31e-07	5	132	3	7589796
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	ERBB2 EEF1A1 EEF1A1P5 EEF1A2 SLC25A3 YTHDF1 EGFR PRKCSH BAIAP2	6.36e-07	256	132	9	24189400
Pubmed	Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice.	ERBB2 ERBB4 EGFR	1.06e-06	6	132	3	32335999
Pubmed	The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.	ERBB2 ERBB4 EGFR	1.06e-06	6	132	3	29190819
Pubmed	Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.	ERBB2 ERBB4 EGFR	1.06e-06	6	132	3	15496447
Pubmed	LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.	ERBB2 ERBB4 EGFR	1.06e-06	6	132	3	15282549
Pubmed	Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland.	ERBB2 ERBB4 EGFR	1.06e-06	6	132	3	11278868
Pubmed	Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.	ERBB2 ERBB4 EGFR	1.85e-06	7	132	3	22504067
Pubmed	Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.	ERBB2 ERBB4 EGFR	1.85e-06	7	132	3	22493501
Pubmed	Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.	ERBB2 ERBB4 EGFR	1.85e-06	7	132	3	17487277
Pubmed	A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk.	ERBB2 ERBB4 EGFR	1.85e-06	7	132	3	20446891
Pubmed	Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.	ERBB2 ERBB4 EGFR	1.85e-06	7	132	3	20126551
Pubmed	Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations.	RELN ERBB4 EGFR	2.95e-06	8	132	3	22376909
Pubmed	Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse.	ERBB2 ERBB4 EGFR	2.95e-06	8	132	3	16488402
Pubmed	Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.	ERBB2 ERBB4 EGFR	2.95e-06	8	132	3	17960183
Pubmed	Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse.	ERBB2 ERBB4 EGFR	2.95e-06	8	132	3	15306553
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 NHSL2 TRPC4 GRIA4 PPIB PGK1 EEF1A1 EEF1A2 NAV1 PRKCA MTCL1 BAIAP2 CAMSAP2 GOLGA1 FOXG1	4.10e-06	963	132	15	28671696
Pubmed	ERBB3-dependent AKT and ERK pathways are essential for atrioventricular cushion development in mouse embryos.	ERBB2 ERBB4 EGFR	4.41e-06	9	132	3	34714866
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	PPIB EEF1A1 EEF1A2 SLC25A3	5.76e-06	31	132	4	19136429
Pubmed	In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons.	ERBB2 ERBB4 EGFR	6.29e-06	10	132	3	19298847
Pubmed	The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.	ERBB2 ERBB4 EGFR	6.29e-06	10	132	3	8702723
Pubmed	Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.	ERBB2 ERBB4 EGFR	6.29e-06	10	132	3	20881644
Pubmed	Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.	ERBB2 ERBB4 EGFR	8.62e-06	11	132	3	25315821
Pubmed	Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.	ERBB2 ERBB4 EGFR	8.62e-06	11	132	3	17822758
Pubmed	Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.	ERBB2 ERBB4 EGFR	8.62e-06	11	132	3	10821760
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	ERBB2 ERBB4 ZAP70 EGFR PRKCA BAIAP2	1.29e-05	134	132	6	24658140
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SART3 DMXL2 RPL35A POLE COX15 RCC1 RRM1 PPIB DMXL1 AAR2 EEF1A2 CLCN7 EGFR NECTIN2 CNDP2 PRKCSH SCFD1 BAIAP2	1.38e-05	1487	132	18	33957083
Pubmed	Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer.	ERBB2 EGFR	1.43e-05	2	132	2	25349977
Pubmed	Prognostic role of human epidermal growth factor receptor in gastric cancer: a systematic review and meta-analysis.	ERBB2 EGFR	1.43e-05	2	132	2	23871709
Pubmed	Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report.	CHRNA3 EGFR	1.43e-05	2	132	2	20068085
Pubmed	HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer.	ERBB2 EGFR	1.43e-05	2	132	2	23594562
Pubmed	Circulating Bone-related Markers and YKL-40 Versus HER2 and TOPO2a in Bone Metastatic and Nonmetastatic Breast Cancer: Diagnostic Implications.	ERBB2 TNFSF11	1.43e-05	2	132	2	28645722
Pubmed	FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.	ERBB2 FTO	1.43e-05	2	132	2	35524932
Pubmed	Identification of autophosphorylation sites of HER2/neu.	ERBB2 EGFR	1.43e-05	2	132	2	1706616
Pubmed	Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells.	ERBB2 EGFR	1.43e-05	2	132	2	19946741
Pubmed	EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.	ERBB2 EGFR	1.43e-05	2	132	2	38416376
Pubmed	Evolutionary analysis of the ErbB receptor and ligand families.	ERBB2 EGFR	1.43e-05	2	132	2	10824084
Pubmed	Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system.	ERBB2 ERBB4	1.43e-05	2	132	2	20022944
Pubmed	Synergistic Blockade of EGFR and HER2 by New-Generation EGFR Tyrosine Kinase Inhibitor Enhances Radiation Effect in Bladder Cancer Cells.	ERBB2 EGFR	1.43e-05	2	132	2	25589492
Pubmed	Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization study.	ERBB2 EGFR	1.43e-05	2	132	2	15143334
Pubmed	Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists.	EGFR PRKCA	1.43e-05	2	132	2	17307332
Pubmed	Impact of common epidermal growth factor receptor and HER2 variants on receptor activity and inhibition by lapatinib.	ERBB2 EGFR	1.43e-05	2	132	2	18199554
Pubmed	Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium.	ERBB2 EGFR	1.43e-05	2	132	2	17549377
Pubmed	The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F.	ERBB2 EGFR	1.43e-05	2	132	2	27502168
Pubmed	Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.	ERBB2 EGFR	1.43e-05	2	132	2	23665199
Pubmed	Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation.	ERBB2 EGFR	1.43e-05	2	132	2	25217659
Pubmed	Continuous application of compressive force induces fusion of osteoclast-like RAW264.7 cells via upregulation of RANK and downregulation of LGR4.	LGR4 TNFSF11	1.43e-05	2	132	2	29572179
Pubmed	EGFR and HER2 expression in advanced biliary tract cancer.	ERBB2 EGFR	1.43e-05	2	132	2	19777609
Pubmed	Increased concentrations of growth factors and activation of the EGFR system in breast cancer.	ERBB2 EGFR	1.43e-05	2	132	2	23089711
Pubmed	EGFR Expression in HER2-Driven Breast Cancer Cells.	ERBB2 EGFR	1.43e-05	2	132	2	33260837
Pubmed	The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma.	ERBB2 EGFR	1.43e-05	2	132	2	34487971
Pubmed	Screening and validation of dinucleotide repeats in intron 1 of the human EGFR gene and its paralog in the HER2 gene.	ERBB2 EGFR	1.43e-05	2	132	2	18946768
Pubmed	Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.	CD163 CD163L1	1.43e-05	2	132	2	11124526
Pubmed	Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors.	ERBB2 EGFR	1.43e-05	2	132	2	27273260
Pubmed	Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR.	ERBB2 EGFR	1.43e-05	2	132	2	12354693
Pubmed	Characterization of EGFR family gene aberrations in cholangiocarcinoma.	ERBB2 ERBB4	1.43e-05	2	132	2	24927194
Pubmed	Fluorescence-Raman dual modal endoscopic system for multiplexed molecular diagnostics.	ERBB2 EGFR	1.43e-05	2	132	2	25820115
Pubmed	Expression of EGFR, Her2 predict lymph node metastasis (LNM)-associated metastasis in colorectal cancer.	ERBB2 EGFR	1.43e-05	2	132	2	23220854
Pubmed	A single ligand is sufficient to activate EGFR dimers.	ERBB2 ERBB4	1.43e-05	2	132	2	22699492
Pubmed	Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation.	ERBB2 EGFR	1.43e-05	2	132	2	20156584
Pubmed	EGFR and HER-2 oncogenes expression in an experimental model of two-stage chemically induced carcinogenesis in mouse skin.	ERBB2 EGFR	1.43e-05	2	132	2	38443188
Pubmed	Differential spatial expression and activation pattern of EGFR and HER2 in human breast cancer.	ERBB2 EGFR	1.43e-05	2	132	2	17611648
Pubmed	A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells.	ERBB2 EGFR	1.43e-05	2	132	2	26437915
Pubmed	EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection.	ERBB2 EGFR	1.43e-05	2	132	2	22891338
Interaction	NHERF1 interactions	ERBB2 TRPC4 RIPOR3 YTHDF1 EGFR CNDP2 PRKCA BAIAP2 FTO	2.60e-06	183	128	9	int:NHERF1
Interaction	NRG1 interactions	ERBB2 ERBB4 LGR4 TM2D3 GLOD4 EGFR TMEM181	5.11e-06	106	128	7	int:NRG1
Interaction	FER1L6 interactions	EEF1A1 EEF1A1P5 EEF1A2	8.60e-06	7	128	3	int:FER1L6
Interaction	TPT1 interactions	SART3 RPL35A ERN1 NHSL2 RFC1 PGK1 HDGFL3 EEF1A1 EEF1A2 PER2 EGFR	1.29e-05	345	128	11	int:TPT1
Interaction	SLA2 interactions	ERBB2 ERBB4 ZAP70 EGFR	1.49e-05	24	128	4	int:SLA2
Interaction	SH2B3 interactions	ERBB2 ERBB4 ZAP70 EGFR	1.77e-05	25	128	4	int:SH2B3
Interaction	MUC4 interactions	ERBB2 ERBB4 EGFR	2.04e-05	9	128	3	int:MUC4
Interaction	MAGEA1 interactions	SPAG1 RNF166 MYO10 EEF1A1 EEF1A2 RCOR3	3.19e-05	95	128	6	int:MAGEA1
Interaction	SLA interactions	ERBB2 ERBB4 ZAP70 EGFR	3.26e-05	29	128	4	int:SLA
Interaction	PTPRT interactions	ERBB2 ERBB4 EGFR	3.98e-05	11	128	3	int:PTPRT
Interaction	LIPC interactions	PPIB EEF1A1 EEF1A2 SLC25A3	6.21e-05	34	128	4	int:LIPC
GeneFamily	Erb-b2 receptor tyrosine kinases	ERBB2 ERBB4 EGFR	4.00e-07	4	85	3	1096
GeneFamily	Sulfotransferases, cytosolic	SULT1B1 SULT1C3	1.92e-03	14	85	2	762
GeneFamily	Immunoglobulin like domain containing	IL1RAPL1 IL1RAPL2 NECTIN2 CNTN3 IGSF3	2.16e-03	193	85	5	594
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL1RAPL1 IL1RAPL2	2.20e-03	15	85	2	1296
GeneFamily	Dyneins, axonemal	DNAH3 DNAH7	2.84e-03	17	85	2	536
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ERBB4 ANGPT1 EGFR IL1RAPL2 NECTIN2 TMEM200C	1.17e-06	181	132	7	03a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPAG1 ERN1 ZAP70 TNFSF11 CD163L1 TMEM200C	1.34e-05	174	132	6	6987fe7959afce347282f632abc16d800ccab7c4
ToppCell	droplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SLC25A30 PKHD1L1 OVGP1 NECTIN2 FOXC2	2.02e-05	187	132	6	9c9ae8725905ba0cfe407878006ed06c2480fb72
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ERBB4 ANGPT1 EGFR IL1RAPL2 TMEM200C	2.02e-05	187	132	6	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SLC25A30 PKHD1L1 OVGP1 NECTIN2 FOXC2	2.02e-05	187	132	6	9e9460e57cdc9cd0a0de2866b140e06d0bc19a8f
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN SLC25A30 PKHD1L1 OVGP1 NECTIN2 FOXC2	2.08e-05	188	132	6	dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RPL35A ZAP70 HDGFL3 EEF1A1 PRKCA CMAHP	2.08e-05	188	132	6	467773d1e6b4828495a62f3b92996964d1c94b97
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN SLC25A30 PKHD1L1 OVGP1 NECTIN2 FOXC2	2.08e-05	188	132	6	2ef08313087e91985bcffc46c3798470cdeec49c
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN SLC25A30 PKHD1L1 OVGP1 NECTIN2 FOXC2	2.08e-05	188	132	6	1f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCell	control-Myeloid-CD14_Monocytes_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	DMXL2 TEX14 CD163 SLC25A3 CNDP2 NAV1	2.14e-05	189	132	6	7f78b5bb8195f99b18082cbb612e9199b7a1538c
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN ANKRD2 NECTIN2 TMEM200C IGSF3 FOXC2	2.27e-05	191	132	6	51cff0594ac7ad8c065c8ea2301f8c149bd062b4
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN ANKRD2 NECTIN2 TMEM200C IGSF3 FOXC2	2.27e-05	191	132	6	a55b6f0a7ec1a8852ffca593cfdccd7edea09b7b
ToppCell	droplet-Lung-30m-Endothelial-lymphatic_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN ANKRD2 NECTIN2 TMEM200C IGSF3 FOXC2	2.27e-05	191	132	6	38681a1b182d6af5cce85db5431b6eba4b20ad96
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ERBB4 ANGPT1 EGFR CD163L1 IGSF3	2.34e-05	192	132	6	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	CV-Severe-5\|CV / Virus stimulation, Condition and Cluster	RPL35A RCC1 PGK1 EEF1A1 TNFSF11 PRKCA	2.41e-05	193	132	6	d87fcd4553b6198c3128685b73ffd1b1ae88fbb5
ToppCell	CV-Moderate-5\|Moderate / Virus stimulation, Condition and Cluster	PSMA2 RCC1 PGK1 EEF1A1 TNFSF11 PRKCA	2.55e-05	195	132	6	646d06ac3fa20acb172735c88cf45e01d212cebf
ToppCell	control-unassigned\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PECR POLE ZAP70 RCOR3 OLFM2 LGR6	2.86e-05	199	132	6	5db7c8089172ac8e796613b3cef618d87007a0ab
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Interneuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	ERBB4 RPL35A EEF1A1 IL1RAPL1 IL1RAPL2 CBLN2	2.94e-05	200	132	6	a313b9a8bde1ea80a6eae183b76fba46b86558b4
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Macroglial-Astrocyte\|1m / Sample Type, Dataset, Time_group, and Cell type.	RPL35A MYO10 RBP4 EEF1A1 DECR1 OLFM3	2.94e-05	200	132	6	4a6efb1b756995d217aacc38639c1bd40f1fd725
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	RELN ERBB4 ANGPT1 EGFR IL1RAPL2 TMEM200C	2.94e-05	200	132	6	8a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 RIPOR3 EEF1A1 TNFSF11 CD163L1	6.12e-05	140	132	5	11e441c3435ad8911ab401ca7d4ae1d3e5fa6eac
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DMXL2 RIPOR3 EEF1A1 TNFSF11 CD163L1	6.12e-05	140	132	5	94444b92acfad64d811ebb1545dc1dab64473795
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CNBD1 RELN KDM4E IL1RAPL1 TEX46	7.46e-05	146	132	5	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARL9 PPIB ALG1L2 EEF1A1 FOXC2	7.71e-05	147	132	5	f703cb0330304799d16e457215269c7732c9d5d5
ToppCell	severe_COVID-19-MAIT\|World / disease group, cell group and cell class (v2)	ERN1 MAFA ANKMY1 SCMH1 KCNQ3	9.60e-05	154	132	5	65ec7f7ef05c589903c4c9fe3849478c325fdc61
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 CHRNA3 EGFR CBLN2 IGSF3	9.89e-05	155	132	5	3b8def9e8f66511736ea37f259511f7c8b7743af
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CHRNA3 GLCE KCNQ3 MTCL1 FOXG1	1.02e-04	156	132	5	7e6805ebc7bc2f9c5965321d16922c155719970f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CHRNA3 GLCE KCNQ3 MTCL1 FOXG1	1.02e-04	156	132	5	741de05295b2d012ac8576378f37709a97c8fb50
ToppCell	severe_COVID-19-MAIT\|severe_COVID-19 / disease group, cell group and cell class (v2)	ERN1 MAFA ANKMY1 SCMH1 KCNQ3	1.05e-04	157	132	5	175f637e9707836bd63b5c2ccc9d4eb601c05b9e
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CNBD1 DNAH3 RELN IL1RAPL1 XIRP2	1.12e-04	159	132	5	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAD1 ZAP70 TNFSF11 CD163L1 CMAHP	1.12e-04	159	132	5	8d958d79f5eb3ab683d1245ae7f4f22a2cefbc55
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LHFPL1 KCNC4 CNTN3 PAX1 ZNF44	1.12e-04	159	132	5	1baf0eaf9684668146a63192e77eec6c3c7a37f8
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 CHRNA3 EGFR IGSF3	1.18e-04	161	132	5	3b5d7a3dab479c6959a428f3954dedd989900276
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERBB4 POLE PKHD1L1 CNTN3 LGR6	1.22e-04	162	132	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	facs-Marrow-B-cells-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SLC38A5 NXPE2 TEX14 CD163L1	1.33e-04	165	132	5	361a605d8f833d9ec54b120480dce397da35f9c3
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cfh_(Cfh)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DNAH3 FMO4 SLC38A5 ANKMY1	1.36e-04	88	132	4	5582666aed9c1f465264f18898783872b662400d
ToppCell	(05)_Ciliated-(1)_24hpi\|(05)_Ciliated / shred by cell type and Timepoint	CWH43 ALS2 OVGP1 CD163L1	1.36e-04	88	132	4	76959e7e3f6fae07c9881a29c28ba847be406694
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cfh_(Cfh)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DNAH3 FMO4 SLC38A5 ANKMY1	1.36e-04	88	132	4	5f774a85415d3cf163046f1154a82f749bf628fe
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Cfh_(Cfh)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DNAH3 FMO4 SLC38A5 ANKMY1	1.36e-04	88	132	4	f59eeaba4a3c5ef03f741ed6a31fe88f57651374
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CYP26B1 CHRNA3 XIRP2 GLCE PRKCA	1.36e-04	166	132	5	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CERK ERN1 ZAP70 EEF1A1 KCNQ3	1.36e-04	166	132	5	bb93db4613c067c56614ab1ca39e73ee46484387
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CERK ERN1 ZAP70 EEF1A1 KCNQ3	1.36e-04	166	132	5	c1f17a028bb27b8f202bcfffa7de7373b1cdd990
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ERN1 TSEN54 RRM1 CSGALNACT2 SMG7	1.44e-04	168	132	5	27cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 CHRNA3 EGFR IGSF3	1.44e-04	168	132	5	f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ERBB2 NXPE2 B3GNT6 EGFR FOXC2	1.48e-04	169	132	5	aec97583b23112060437b619cb429dc32f29285f
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LGR4 SLC38A5 CLCN7 SERGEF LGR6	1.52e-04	170	132	5	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	DMXL2 CD163 FOXD4L1 XIRP2 CD163L1	1.52e-04	170	132	5	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 EGFR CBLN2 IGSF3	1.52e-04	170	132	5	14aa86a4f526ed6986afcb28c49225522055550c
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZAP70 HDGFL3 EEF1A1 PRKCA CMAHP	1.52e-04	170	132	5	8e9b5f7bfb61f8d84d0b17fb0c191da4dabad63d
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLE RCC1 PER2 PRDM6 WIPI2	1.52e-04	170	132	5	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 EGFR CBLN2 IGSF3	1.57e-04	171	132	5	5efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 CHRNA3 EGFR CBLN2 IGSF3	1.57e-04	171	132	5	f9ae7964a3740f559431125c17c660549798cccc
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANGPT1 IL1RAPL1 LGR6 PRDM6 FOXC2	1.57e-04	171	132	5	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 EGFR CBLN2 IGSF3	1.61e-04	172	132	5	7e1a7700a4c2b1d100da1d6e475e73498ebb605a
ToppCell	droplet-Heart-HEART-1m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SLC25A30 PKHD1L1 NECTIN2 FOXC2	1.65e-04	173	132	5	9dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCell	IIH-CD8-naive_CD4\|IIH / Condition, Cell_class and T cell subcluster	POLE SLC38A5 COX15 ANKMY1 CLCN7	1.65e-04	173	132	5	4f2843371d18af766c1892529ce286f56c956fde
ToppCell	droplet-Marrow-nan-24m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT1 ZAP70 HDGFL3 EEF1A1 PRKCA	1.70e-04	174	132	5	955a3de6b7efc117f34c14faf8051f41454275dd
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 CHRNA3 EGFR CBLN2 IGSF3	1.70e-04	174	132	5	a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 MYO10 EGFR MTCL1 IGSF3	1.70e-04	174	132	5	110369f6b78de34a6d934b5b47cecd023347bc80
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF1A2 XIRP2 ANKRD2 PXMP2 KCNQ3	1.70e-04	174	132	5	4a6e04b4f12b87c15fa1409989cbe32c43736369
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG1 SLFN5 ZAP70 HDGFL3 TNFSF11	1.75e-04	175	132	5	e219b61d6bc078d44ea7d06191d3462654d857a1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPAG1 SLFN5 ZAP70 HDGFL3 TNFSF11	1.75e-04	175	132	5	bd16c80418bf71127e6f1e50edf83967c9218b42
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN RIPOR3 PKHD1L1 NECTIN2 TMEM200C	1.75e-04	175	132	5	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZAP70 HDGFL3 EEF1A1 PRKCA CMAHP	1.75e-04	175	132	5	f949613ee45f5d950578c512d197716855118d18
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN RIPOR3 PKHD1L1 NECTIN2 TMEM200C	1.75e-04	175	132	5	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RBP4 RIPOR3 EGFR OLFM2 KDM1B	1.79e-04	176	132	5	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	Control-Lymphocyte-T_NK-CD8_TCM\|Control / Disease, Lineage and Cell Type	RPL35A SLFN5 ZAP70 EEF1A1 PRKCA	1.79e-04	176	132	5	1a7948eb86ee1da607db4d0576312b2859d94523
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 EGFR CBLN2 IGSF3	1.79e-04	176	132	5	05ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RPL35A ANGPT1 CWH43 EEF1A1 SULT1C3	1.79e-04	176	132	5	b942227abf9902ba13fac6c3e9efb0cacc82af94
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN NXPE2 PKHD1L1 ANKRD2 NECTIN2	1.79e-04	176	132	5	460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ANGPT1 EGFR NECTIN2 IGSF3	1.84e-04	177	132	5	85e270b4a0b0da77ffe5987a099e827c02a4adf3
ToppCell	P28-Endothelial-lymphatic_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN RIPOR3 PKHD1L1 NECTIN2 TMEM200C	1.84e-04	177	132	5	6e330aa3c87fd640526b746a9deb3b2250d2518c
ToppCell	E12.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN NHSL2 SLC25A30 PRDM6 FOXC2	1.84e-04	177	132	5	5cdf413f82376a95467322b16d10b0d1e7557e2d
ToppCell	droplet-Marrow-BM-30m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A5 NXPE2 ZAP70 HDGFL3 CAMSAP2	1.84e-04	177	132	5	650095a17e1a39caea74a6e89646565b9332af5d
ToppCell	P28-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RELN RIPOR3 PKHD1L1 NECTIN2 TMEM200C	1.84e-04	177	132	5	e96a7e4544710aaab8bd2800ecff9667880a8bf4
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPL35A ZAP70 EEF1A1 CD163L1 CMAHP	1.84e-04	177	132	5	81511383b010ab744ebc622c180f926d469194c1
ToppCell	droplet-Marrow-BM-30m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC38A5 NXPE2 ZAP70 HDGFL3 CAMSAP2	1.84e-04	177	132	5	d1af0cb4b1fb03f04cff5add85e29be8fb8f4dcb
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPL35A ZAP70 EEF1A1 CD163L1 CMAHP	1.89e-04	178	132	5	934a2a7b35a23b56e34d4d0ef68c271513ef1fe9
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPL35A ZAP70 EEF1A1 PRKCA CMAHP	1.89e-04	178	132	5	cd0c5f15e6b28ce2208346279ee9503d18d9b27d
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPL35A ZAP70 EEF1A1 PRKCA CMAHP	1.89e-04	178	132	5	813d121a45e0416de1f26862851f6f0bda7ba43c
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp4_Mab21l1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERBB4 ANGPT1 CBLN2 IGSF3	1.91e-04	96	132	4	78f19fee755061b4144b1beebb60f4e8bc4dbf0d
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	RBP4 TNFSF11 EGFR CAMSAP2 FOXC2	1.94e-04	179	132	5	98c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ERBB4 ARL9 EGFR IL1RAPL2	1.94e-04	179	132	5	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPL35A ZAP70 EEF1A1 CD163L1 CMAHP	1.94e-04	179	132	5	20cac7b3035a2bb0b09f58741617550f1f623fc9
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RIPOR3 IL1RAPL1 EGFR CBLN2 PRDM6	1.94e-04	179	132	5	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	metastatic_Lymph_Node-T/NK_cells-Naive_CD8+_T\|metastatic_Lymph_Node / Location, Cell class and cell subclass	RPL35A TSEN54 SLFN5 ZAP70 EEF1A1	1.99e-04	180	132	5	16516dd9c78c27fc76f58d650de9851ffa0763e7
ToppCell	IIH-CD8-CD4_Treg\|IIH / Condition, Cell_class and T cell subcluster	PECR ANKMY1 AAR2 XRN1 ZNF44	1.99e-04	180	132	5	d1a8b25115c80e5a5bd0b8244167a98250ab9778
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DNAH3 RELN ERBB4 EGFR IL1RAPL2	1.99e-04	180	132	5	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ERBB4 EGFR CD163L1 LGR6	2.04e-04	181	132	5	062f00736eed96e4f4327615d093558dd7d82b20
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN PKHD1L1 NECTIN2 TMEM200C IGSF3	2.04e-04	181	132	5	b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCell	RV\|World / Chamber and Cluster_Paper	DECR1 IL1RAPL1 PPP2R3A XIRP2 NAV1	2.04e-04	181	132	5	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN PKHD1L1 NECTIN2 TMEM200C IGSF3	2.04e-04	181	132	5	cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RELN PKHD1L1 NECTIN2 TMEM200C IGSF3	2.04e-04	181	132	5	ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPL35A ZAP70 EEF1A1 CD163L1 CMAHP	2.09e-04	182	132	5	c7e07570480295e1ad3c5fbbb16b8e4df90c690d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 ANGPT1 EGFR NECTIN2 IGSF3	2.09e-04	182	132	5	3d7a8d2ee2137b098248597058974ef5ae09c19e
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT1 ZAP70 HDGFL3 TET1 XRN1	2.09e-04	182	132	5	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT1 ZAP70 HDGFL3 TET1 XRN1	2.09e-04	182	132	5	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RELN ERBB4 EGFR CD163L1 LGR6	2.09e-04	182	132	5	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZAP70 HDGFL3 EEF1A1 PRKCA CMAHP	2.09e-04	182	132	5	6339fc979aa097627924849f436bb9e9c14f4ce3
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-skeletal_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EEF1A2 KCNC4 XIRP2 ANKRD2 PXMP2	2.09e-04	182	132	5	edfc598b7199ca1d8a399b264ab863c299b1eede
Drug	pyrido[3,4-d]pyrimidine	ERBB2 ERBB4 EGFR	1.78e-07	3	129	3	CID014758064
Drug	Androgen Antagonists	ERBB2 RELN ERBB4 GRIA4 IL1RAPL1 CNTN3	4.30e-06	75	129	6	ctd:D000726
Drug	but-2-enamide	ERBB2 DECR1 EGFR	1.46e-05	9	129	3	CID000031877
Drug	benzylidenemalononitrile	ERBB2 ERBB4 DECR1 EGFR	1.56e-05	27	129	4	CID000017608
Drug	Iopromide [73334-07-3]; Up 200; 5uM; MCF7; HT_HG-U133A	CEL RBP4 PPP2R3A SULT1B1 EGFR SERGEF FOXG1 ZNF44	1.70e-05	197	129	8	6842_UP
Drug	raloxifene hydrochloride; Up 200; 0.1uM; HL60; HG-U133A	DNAH3 CHRNA3 CD163 HDGFL3 PPP2R3A PRKCA PAX1 BAIAP2	1.70e-05	197	129	8	388_UP
Drug	GBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; PC3; HT_HG-U133A	DNAH3 CWH43 SULT1B1 SMG7 IL1RAPL2 FOXG1 WIPI2 ZNF44	1.83e-05	199	129	8	4641_DN
Drug	6-(methylamino)pyrido(3,4-d)pyrimidine	ERBB2 ERBB4 EGFR	2.07e-05	10	129	3	ctd:C107875
Drug	celecoxib	ERBB2 ANGPT1 CEL ALS2 TNFRSF10A SULT1B1 TNFSF11 EGFR FOXG1	2.63e-05	273	129	9	CID000002662
Drug	BE-23372M	ERBB2 ERBB4 EGFR	2.84e-05	11	129	3	CID005311105
Drug	procymidone	ERBB2 RELN ERBB4 GRIA4 IL1RAPL1 SULT1B1 EGFR	2.95e-05	155	129	7	ctd:C035988
Drug	Prestwick_517	ERBB2 ERBB4 SLC38A5 EGFR GLCE PAX1	3.16e-05	106	129	6	CID000003804
Drug	N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide	ERBB2 EGFR	3.19e-05	2	129	2	ctd:C570404
Drug	carcinolipin	CEL EEF1A2	3.19e-05	2	129	2	CID000159870
Drug	Lapatinib	ERBB2 EGFR	3.19e-05	2	129	2	DB01259
Disease	developmental and epileptic encephalopathy 33 (implicated_via_orthology)	EEF1A1 EEF1A1P5 EEF1A2	7.97e-08	3	128	3	DOID:0080463 (implicated_via_orthology)
Disease	gallbladder neoplasm	ERBB2 ERBB4 EGFR	1.28e-05	11	128	3	C0016978
Disease	Malignant neoplasm of gallbladder	ERBB2 ERBB4 EGFR	1.28e-05	11	128	3	C0153452
Disease	dilated cardiomyopathy (implicated_via_orthology)	ERBB2 EEF1A1 EEF1A1P5 EEF1A2 EGFR	2.63e-05	80	128	5	DOID:12930 (implicated_via_orthology)
Disease	median neuropathy (biomarker_via_orthology)	ERBB2 ERBB4 EGFR	2.80e-05	14	128	3	DOID:571 (biomarker_via_orthology)
Disease	diastolic blood pressure, systolic blood pressure	ANGPT1 TRPC4 KMT2E DNAH7 PXMP2 NAV1 PRKCA PRKCSH OLFM2 FTO CMAHP PRDM6	3.68e-05	670	128	12	EFO_0006335, EFO_0006336
Disease	Osteopetrosis Autosomal Dominant Type 2	TNFSF11 CLCN7	5.59e-05	3	128	2	C3179239
Disease	Congenital Osteopetrosis	TNFSF11 CLCN7	5.59e-05	3	128	2	C3645711
Disease	lung adenocarcinoma (is_implicated_in)	ERBB2 ERBB4 CHRNA3 EGFR	6.15e-05	49	128	4	DOID:3910 (is_implicated_in)
Disease	Adenocarcinoma of large intestine	ERBB2 ERBB4 POLE EGFR PRKCA	6.33e-05	96	128	5	C1319315
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB2 ERBB4 EGFR	7.34e-05	19	128	3	DOID:2876 (is_marker_for)
Disease	Infantile malignant osteopetrosis	TNFSF11 CLCN7	1.11e-04	4	128	2	C1318518
Disease	transitional cell carcinoma (is_marker_for)	ERBB2 ERBB4 ANGPT1 EGFR	1.65e-04	63	128	4	DOID:2671 (is_marker_for)
Disease	kallikrein-7 measurement	CD163 CD163L1	1.85e-04	5	128	2	EFO_0008195
Disease	Osteopetrosis	TNFSF11 CLCN7	1.85e-04	5	128	2	C0029454
Disease	Cetuximab response	ERBB2 EGFR	1.85e-04	5	128	2	cv:CN077967
Disease	Panitumumab response	ERBB2 EGFR	1.85e-04	5	128	2	cv:CN077999
Disease	smoking behavior, body mass index	DMXL2 ERBB4 NXPE2 NAV1 FTO	2.04e-04	123	128	5	EFO_0004318, EFO_0004340
Disease	alcohol use disorder (implicated_via_orthology)	ERBB2 ERBB4 ANGPT1 CHRNA3 EGFR PRKCA	2.14e-04	195	128	6	DOID:1574 (implicated_via_orthology)
Disease	renal cell carcinoma (is_marker_for)	ERBB2 ERBB4 ANGPT1 TNFRSF10A EGFR	2.45e-04	128	128	5	DOID:4450 (is_marker_for)
Disease	intestinal cancer (implicated_via_orthology)	ERBB2 ERBB4 EGFR	3.61e-04	32	128	3	DOID:10155 (implicated_via_orthology)
Disease	response to paliperidone, schizophrenia symptom severity measurement	PECR CWH43 CEL EPG5 CBLN2 PRKCSH	3.71e-04	216	128	6	EFO_0007925, EFO_0007927
Disease	abdominal aortic artery calcification	NECTIN2 NAV1	3.87e-04	7	128	2	EFO_0004859
Disease	liver cirrhosis (is_marker_for)	RELN RBP4 CD163 EGFR	4.55e-04	82	128	4	DOID:5082 (is_marker_for)
Disease	head and neck squamous cell carcinoma (is_marker_for)	ERBB2 ERBB4	5.14e-04	8	128	2	DOID:5520 (is_marker_for)
Disease	ductal carcinoma in situ (is_marker_for)	ERBB2 ERBB4 PRKCA	6.50e-04	39	128	3	DOID:0060074 (is_marker_for)
Disease	autistic disorder (is_implicated_in)	RELN KMT2E KCNQ3	8.09e-04	42	128	3	DOID:12849 (is_implicated_in)
Disease	Head and Neck Carcinoma	ERBB2 EGFR	8.21e-04	10	128	2	C3887461
Disease	Cognitive impairment	DMXL1 NECTIN2	1.00e-03	11	128	2	HP_0100543
Disease	Papilloma	ERBB2 EGFR	1.20e-03	12	128	2	C0030354
Disease	Papillomatosis	ERBB2 EGFR	1.20e-03	12	128	2	C0205875
Disease	Papilloma, Squamous Cell	ERBB2 EGFR	1.20e-03	12	128	2	C0205874
Disease	urinary bladder cancer (is_marker_for)	ERBB2 ERBB4 EGFR PRKCA	1.23e-03	107	128	4	DOID:11054 (is_marker_for)
Disease	Neoplasm of lung	ERBB2 EGFR	1.64e-03	14	128	2	cv:C0024121
Disease	Lung cancer	ERBB2 EGFR	1.64e-03	14	128	2	cv:C0242379
Disease	LUNG CANCER	ERBB2 EGFR	1.64e-03	14	128	2	211980
Disease	ovarian cancer (is_implicated_in)	ERBB2 EEF1A2 PRKCA	1.87e-03	56	128	3	DOID:2394 (is_implicated_in)
Disease	Stomach Neoplasms	ERBB2 POLE RBP4 EEF1A1 EEF1A2 EGFR	1.92e-03	297	128	6	C0038356
Disease	colorectal cancer (is_implicated_in)	ERBB4 POLE YTHDF1 EGFR	1.94e-03	121	128	4	DOID:9256 (is_implicated_in)
Disease	Malignant neoplasm of stomach	ERBB2 POLE RBP4 EEF1A1 EEF1A2 EGFR	2.02e-03	300	128	6	C0024623
Disease	urate measurement, spine bone mineral density	EGFR PRDM6 RIC1	2.07e-03	58	128	3	EFO_0004531, EFO_0007701
Disease	Benign neoplasm of stomach	ERBB2 POLE	2.43e-03	17	128	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB2 POLE	2.43e-03	17	128	2	C0496905
Disease	Antibody Deficiency Syndrome	ZAP70 EPG5	2.43e-03	17	128	2	C0003257
Disease	Carcinoma in situ of stomach	ERBB2 POLE	2.43e-03	17	128	2	C0154060
Disease	oral squamous cell carcinoma (is_marker_for)	ERBB2 ERBB4 EGFR	2.62e-03	63	128	3	DOID:0050866 (is_marker_for)
Disease	Adrenocortical carcinoma	RRM1 EGFR	2.73e-03	18	128	2	C0206686
Disease	Malignant neoplasm of endometrium	POLE EGFR	2.73e-03	18	128	2	C0007103
Disease	Carcinoma in situ of endometrium	POLE EGFR	2.73e-03	18	128	2	C0346191
Disease	carcinoma (implicated_via_orthology)	ERBB2 ERBB4 EGFR	2.74e-03	64	128	3	DOID:305 (implicated_via_orthology)
Disease	facial asymmetry measurement	CNBD1 MYO10	3.04e-03	19	128	2	EFO_0009751
Disease	interstitial lung disease	SPAG1 CWH43 NAV1	3.12e-03	67	128	3	EFO_0004244
Disease	cortical thickness	CNBD1 RELN ANGPT1 LGR4 GLOD4 HDGFL3 TNFSF11 SMG7 EGFR NAV1 MTCL1 FOXC2	3.36e-03	1113	128	12	EFO_0004840
Disease	renal cell carcinoma (is_implicated_in)	ERBB2 TNFRSF10A FTO	3.39e-03	69	128	3	DOID:4450 (is_implicated_in)
Disease	Animal Mammary Neoplasms	ERBB2 RBP4 EEF1A1 EGFR	3.46e-03	142	128	4	C0024667
Disease	Mammary Carcinoma, Animal	ERBB2 RBP4 EEF1A1 EGFR	3.46e-03	142	128	4	C1257925
Disease	cardiomyopathy (implicated_via_orthology)	ERBB2 ERBB4 EGFR	3.68e-03	71	128	3	DOID:0050700 (implicated_via_orthology)
Disease	bone density, lean body mass	TNFSF11 FTO	3.71e-03	21	128	2	EFO_0003923, EFO_0004995
Disease	Stomach Carcinoma	ERBB2 POLE	3.71e-03	21	128	2	C0699791
Disease	glioma	GRIA4 EGFR	4.07e-03	22	128	2	EFO_0005543
Disease	lung cancer (is_implicated_in)	POLE TRPC4 CHRNA3	4.13e-03	74	128	3	DOID:1324 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TVWELMTFGAKPYDG	ERBB2	911	P04626
YGVTIWELMTFGGKP	ERBB4	906	Q15303
FKSFGLFSKWSPYMA	EPG5	1911	Q9HCE0
LKWNPSDYGGAEFMR	CHRNA3	96	P32297
YTLGFWKTFPGKMTD	ALS2	891	Q96Q42
MGATAGWAVTVYDKP	ALG1L2	1	C9J202
YNSWEVGPKFRGVKM	AAR2	36	Q9Y312
GGSKPFRSYWEMYLS	ARL9	71	Q6T311
PTGWSSESYGLSKMA	ADAD1	36	Q96M93
GEGFKSLEPGWYSAM	GLCE	431	O94923
WKEYKMGFGNPSGEY	ANGPT1	341	Q15389
TGFSWRKTSKYMPRG	DMXL2	236	Q8TDJ6
FGMTYFKEASGPIWL	CD163L1	526	Q9NR16
AYWTNFAKTGDPNMG	CEL	486	P19835
GFSWRKTSKYMPRAS	DMXL1	236	Q9Y485
WRYMGGFAKSVSFSD	NDUFB3	51	O43676
YTDKDNGGMLVWSPY	RCOR3	21	Q9P2K3
TKDGRVFAWGMGTNY	RCC1	361	P18754
WDTGYPKRSAGEAFM	OLFM2	361	O95897
FGSYKQAEWRPDSTM	RIC1	66	Q4ADV7
PGMAQKGYSESAWAR	MTCL1	1731	Q9Y4B5
KARFSMPGDNEGLWY	ACP7	216	Q6ZNF0
AYMPKAAGSWVAGST	OR13C7	141	P0DN81
KGWAPTFLGYSMQGL	SLC25A3	121	Q00325
EGLKAFYKGVAPLWM	SLC25A3	211	Q00325
GTSGKPALEDLYWMS	MAFA	106	Q8NHW3
ETLEYKMSWFGSKPA	GOLGA1	736	Q92805
PYGMCASFFKASGQW	LGR6	481	Q9HBX8
SKPYDGKWSKTMVGF	GLOD4	61	Q9HC38
KEEPYFGMGKMAVSW	FTO	216	Q9C0B1
SWIGPDHDKFSAMKY	PRKCSH	451	P14314
LDGFQIPKGWSVMYS	CYP26B1	381	Q9NR63
YVFGPNGGSSWMREK	KCNQ3	816	O43525
TGAAIWADPGKYALM	CLCN7	536	P51798
STGPRKVGYWNDMDK	GRIA4	381	P48058
GLTFMDRAGSLYWPM	FOXG1	296	P55316
YKLPLWSMCSGADSF	PER2	246	O15055
GLSLMWYKSSGPGDF	IL1RAPL1	71	Q9NZN1
FGYSGDVSPLIYWMK	IL1RAPL1	271	Q9NZN1
MASWAKGRSYLAPGL	PECR	1	Q9BY49
SKPASMSHYLKAWGA	FMO4	506	P31512
AKYMALIKEWPGYGS	MYO10	1941	Q9HD67
NFATPRWIDYGKMAS	KDM4E	291	B2RXH2
GTMYSSWVKSPDRTG	KMT2E	1061	Q8IZD2
TGAFKPCEYLLGSWM	LGR4	526	Q9BXB1
GKGSYWTLDPDSYNM	FOXC2	141	Q99958
PVSYFSQKGAWMDLS	JRKL	246	Q9Y4A0
YWLFGSQMGKPVSFS	LHFPL1	31	Q86WI0
WMDPSNYGGIKGKVS	POLE	1916	Q07864
WMGLDCGPESSKKYA	PGK1	311	P00558
AGDLVFAKMKGYPHW	HDGFL3	11	Q9Y3E1
YWKAPMFRAAGGEKT	PPP2R3A	761	Q06190
DAGMSWFLVKEGCYP	RELN	1326	P78509
FIDGGEPSKSSWMRY	PRDM6	311	Q9NQX0
SEGTAYSPKMEDWAG	PAX1	311	P15863
SKSLAAEWGKYGMRF	DECR1	221	Q16698
GVTVWELMTFGSKPY	EGFR	901	P00533
MAKAPSWAGVGALAY	ANKRD2	1	Q9GZV1
KKDSGFWRDFGFGMT	CSGALNACT2	421	Q8N6G5
SPSGMWYKRAEDTAG	IGSF3	926	O75054
PWIQMAYSFVKTGGS	KDM1B	761	Q8NB78
MSALNWKPFVYGGLA	SLC25A30	1	Q5SVS4
PSGSGKMIEDYWGVS	DNAH3	2816	Q8TD57
MSGEVGRITKWKYPF	ERN1	256	O75460
GSGKWQKMEKPYAFT	CERK	71	Q8TCT0
AAEMGKGSFKYAWVL	EEF1A2	46	Q05639
AAEMGKGSFKYAWVL	EEF1A1	46	P68104
DMIFYGFLKPWLGDG	CYP4F11	121	Q9HBI6
WMGKSYPSLKPLGSY	DNAH7	3836	Q8WXX0
NLMGGWKYSTFSGFL	CBLN2	206	Q8IUK8
FGLNMKLGYGKFSWP	ANKMY1	6	Q9P2S6
YTPMKGGISNVWFDR	LYPLAL1	66	Q5VWZ2
AAEMGKGSFKYAWVL	EEF1A1P5	46	Q5VTE0
GKGTYWSLDPASQDM	FOXD4L1	176	Q9NU39
AGLVYNSFPKMGESW	COX15	286	Q7KZN9
MEGSVPIRDSWSKYF	B3GNT6	251	Q6ZMB0
VFYNGAWGTVGKSSM	CD163	841	Q86VB7
RAVAAATYKTMGPAW	SART3	41	Q15020
SMSYVDGFIGTWPKE	CAMSAP2	416	Q08AD1
RYWNGGGKEESSSKM	CNTN3	841	Q9P232
VMKSWSTGYPKRSAG	OLFM3	381	Q96PB7
PKSSAYAMNYWRKLG	OVGP1	236	Q12889
YDSGSLKMEPGTSKW	NAV1	486	Q8NEY1
MWLGEKLGFYTDFGP	CWH43	481	Q9H720
MSGRLWSKAIFAGYK	RPL35A	1	P18077
TETGKMFTWGRADYG	SERGEF	281	Q9UGK8
RKGMPGDWKNYFTVA	SULT1C3	266	Q6IMI6
GKAMPWFQFYLTGAT	TEX14	211	Q8IWB6
LKSPAGKFWQTMGFS	TSEN54	91	Q7Z6J9
DAFGAAAMLAKGSWP	TMEM200C	271	A6NKL6
FGVSELMKMPASGWY	PRKCA	261	P17252
SWKGDAFTYMTPSAT	NHSL2	391	Q5HYW2
FPSGYTLKKMWITAF	NXPE2	326	Q96DL1
GYMTQFPTFPSWLGK	RFC1	951	P35251
SAMPWGDPSYKSANF	RNF166	186	Q96A37
TFLYMDPEGDWFLKG	SLC38A5	156	Q8WUX1
FSGESGPMIYWMKGE	IL1RAPL2	271	Q9NP60
WKTDKPAMGGFGIDY	SMG7	1046	Q92540
ENFKLKHYGPGWVSM	PPIB	126	P23284
EEPTTWTGYFGKVLM	WIPI2	286	Q9Y4P8
FMRKGTAGDWKNYFT	SULT1B1	256	O43704
MGSPLGHFTWDKYLK	SCMH1	21	Q96GD3
WSMYFNGCKFGRSPS	TET1	1581	Q8NFU7
GVWSMPSKYSEEGVY	ABHD10	201	Q9NUJ1
GESEKTKMRGWFPFS	BAIAP2	416	Q9UQB8
PMTFSGGKFTEEWKA	CMAHP	211	Q9Y471
WFYIDFGGVKPMGSE	SLC25A13	606	Q9UJS0
LPSYDSMLSKWSTFG	CNBD1	251	Q8NA66
VYMGHGGKPWVSDFS	CNDP2	376	Q96KP4
GGDVKYTTWMFETQP	XIRP2	436	A4UGR9
MSGLNWKPFVYGGLA	SLC25A14	36	O95258
GVTMWEALSYGQKPY	ZAP70	526	P43403
DASAFAAKMRGGFWP	PXMP2	136	Q9NR77
KFSMGSRKGSLYNWT	RIPOR3	331	Q96MK2
TSMHFYGWKQGLKTG	RRM1	721	P23921
KGMNFTWKTYNPAFS	TMEM181	296	Q9P2C4
ARFSGTWYAMAKKDP	RBP4	36	P02753
MTTKDYPSLWGFGTT	SPAG1	1	Q07617
VPGYTKKVGSEWMYS	XRN1	966	Q8IZH2
PSGAYFAWKATAMGK	PSMA2	151	P25787
WKAFTKMASAPASYG	SCFD1	496	Q8WVM8
YNEKTPGYMGASWVD	PKHD1L1	361	Q86WI1
TAGPGDALYAMLMKW	TNFRSF10A	401	O00220
MKGGSTKYWSGNSEF	TNFSF11	256	O14788
FTAWYSDMETPLKAG	TRIM16	476	O95361
GTFWGYPKMLEAANL	ZNF44	6	P15621
FSKWDAGCKGYSMIV	SLFN5	456	Q08AF3
GTIGAVAAWLMSYKP	TEX46	11	H3BTG2
TFPKMLYCNWTGGYK	TM2D3	171	Q9BRN9
KLWMSYFEEGGTLPT	TRPC4	641	Q9UBN4
EMKSPVDYGTSAGVW	YTHDF1	451	Q9BYJ9
TLGYGDMYPKTWSGM	KCNC4	436	Q03721
FYMLKGSWEAGNPSC	NLRP14	491	Q86W24
EFATFPKGSVRGMTW	NECTIN2	141	Q92692