Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	betaine-homocysteine S-methyltransferase activity	BHMT BHMT2	8.26e-05	2	182	2	GO:0047150
GeneOntologyMolecularFunction	structural constituent of postsynaptic actin cytoskeleton	POTEF POTEE POTEI	1.16e-04	11	182	3	GO:0098973
GeneOntologyMolecularFunction	fructose-bisphosphate aldolase activity	ALDOA ALDOC	2.46e-04	3	182	2	GO:0004332
GeneOntologyMolecularFunction	neuregulin receptor activity	ERBB3 ERBB4	2.46e-04	3	182	2	GO:0038131
GeneOntologyMolecularFunction	microtubule motor activity	KIF1A KIF26B DNAH14 STARD9 DYNC1I1	4.46e-04	70	182	5	GO:0003777
GeneOntologyMolecularFunction	histone H2B deubiquitinase activity	USP36 USP22	4.90e-04	4	182	2	GO:0140936
GeneOntologyMolecularFunction	zinc ion binding	TRIM72 DUSP12 ZCCHC9 MYBBP1A USP22 DBF4B RNF144A PPARD HNF4A PLA2G15 BHMT OTUD7B ACE2 AARS2 APEX2 BHMT2 HERC2 L3MBTL3 KPNB1	5.18e-04	891	182	19	GO:0008270
GeneOntologyBiologicalProcess	neuron projection morphogenesis	RELN KIF1A LYPLA2 POTEF SARM1 PCDHAC2 SRGAP2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN LGR6 POTEI PHACTR1	1.74e-07	802	182	24	GO:0048812
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	RELN KIF1A LYPLA2 POTEF SARM1 PCDHAC2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN LGR6 POTEI PHACTR1	1.99e-07	748	182	23	GO:0048667
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	RELN KIF1A LYPLA2 POTEF SARM1 PCDHAC2 SRGAP2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN LGR6 POTEI PHACTR1	2.55e-07	819	182	24	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	RELN KIF1A LYPLA2 POTEF SARM1 PCDHAC2 SRGAP2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN LGR6 POTEI PHACTR1	2.97e-07	826	182	24	GO:0048858
GeneOntologyBiologicalProcess	axonogenesis	RELN LYPLA2 POTEF PCDHAC2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 GLI3 LRP1 LRP4 MACF1 LGR6 POTEI	2.90e-06	566	182	18	GO:0007409
GeneOntologyBiologicalProcess	axon development	RELN LYPLA2 POTEF PCDHAC2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 LGR6 POTEI	4.30e-06	642	182	19	GO:0061564
GeneOntologyBiologicalProcess	cell morphogenesis	RELN KIF1A LYPLA2 POTEF ADAM7 SARM1 PCDHAC2 SRGAP2 ARTN POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN LGR6 POTEI ALDOA NOTCH4 PHACTR1	6.37e-06	1194	182	27	GO:0000902
GeneOntologyBiologicalProcess	neuron development	ONECUT2 RELN KIF1A LYPLA2 POTEF SARM1 PCDHAC2 SRGAP2 ARTN GPRIN1 NPHP4 POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 NF1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN DCLK2 LGR6 DENND5A POTEI PHACTR1	1.26e-05	1463	182	30	GO:0048666
GeneOntologyBiologicalProcess	neuron projection development	RELN KIF1A LYPLA2 POTEF SARM1 PCDHAC2 SRGAP2 ARTN GPRIN1 POTEE UNC5A LIMK1 ARHGEF40 CYFIP1 NF1 LLGL1 HMCN2 PTPRF GLI3 LRP1 LRP4 MACF1 AFDN LGR6 DENND5A POTEI PHACTR1	2.37e-05	1285	182	27	GO:0031175
GeneOntologyBiologicalProcess	axon guidance	RELN LYPLA2 PCDHAC2 ARTN UNC5A ARHGEF40 CYFIP1 HMCN2 GLI3 LRP1 LGR6	4.79e-05	285	182	11	GO:0007411
GeneOntologyBiologicalProcess	neuron projection guidance	RELN LYPLA2 PCDHAC2 ARTN UNC5A ARHGEF40 CYFIP1 HMCN2 GLI3 LRP1 LGR6	4.94e-05	286	182	11	GO:0097485
GeneOntologyBiologicalProcess	cell junction organization	RELN ERBB4 KIF1A POTEF SARM1 SRGAP2 HNF4A GRM6 NPHP4 ACE2 POTEE CYFIP1 NF1 HMCN2 PTPRF SRGAP3 CD47 LRP1 LRP4 MACF1 AFDN POTEI	5.06e-05	974	182	22	GO:0034330
GeneOntologyBiologicalProcess	synapse organization	RELN ERBB4 KIF1A POTEF SARM1 SRGAP2 GRM6 POTEE CYFIP1 NF1 HMCN2 PTPRF SRGAP3 CD47 LRP4 AFDN POTEI	1.25e-04	685	182	17	GO:0050808
GeneOntologyBiologicalProcess	actin filament-based process	ESPN ARHGEF19 NEURL2 POTEF SRGAP2 NPHP4 POTEE LIMK1 CYFIP1 NF1 LLGL1 RNH1 SCN3A SCN8A CD47 LRP1 POTEI ALDOA CNN1 PHACTR1	1.68e-04	912	182	20	GO:0030029
GeneOntologyCellularComponent	axon	RELN ACADM KIF1A ADAM21 POTEF SARM1 GPRIN1 POTEE LIMK1 CYFIP1 NF1 LLGL1 HMCN2 PTPRF SACS SCN3A SCN8A LRP1 DGKI AFDN POTEI ALDOC USH2A DYNC1I1	1.00e-06	891	183	24	GO:0030424
Domain	Ank_2	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	6.69e-06	215	177	11	PF12796
Domain	Ank	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	1.17e-05	228	177	11	PF00023
Domain	-	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	2.55e-05	248	177	11	1.25.40.20
Domain	ANK	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	2.84e-05	251	177	11	SM00248
Domain	ANK_REPEAT	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	3.06e-05	253	177	11	PS50088
Domain	Ankyrin_rpt-contain_dom	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	3.17e-05	254	177	11	IPR020683
Domain	ANK_REP_REGION	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	3.17e-05	254	177	11	PS50297
Domain	EGF_1	SELL RELN ADAM21 F12 EYS HMCN2 LRP1 LRP4 HABP2 USH2A NOTCH4	3.29e-05	255	177	11	PS00022
Domain	Ankyrin_rpt	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4	4.21e-05	262	177	11	IPR002110
Domain	EGF_3	SELL RELN ADAM21 F12 EYS HMCN2 LRP1 LRP4 HABP2 NOTCH4	8.44e-05	235	177	10	PS50026
Domain	Betaine-hCys_S-MeTrfase_BHMT	BHMT BHMT2	8.93e-05	2	177	2	IPR017226
Domain	EGF-like_dom	SELL RELN ADAM21 F12 EYS HMCN2 LRP1 LRP4 HABP2 NOTCH4	1.36e-04	249	177	10	IPR000742
Domain	EGF_CA	F12 EYS HMCN2 LRP1 LRP4 HABP2 NOTCH4	1.63e-04	122	177	7	SM00179
Domain	EGF-like_Ca-bd_dom	F12 EYS HMCN2 LRP1 LRP4 HABP2 NOTCH4	1.81e-04	124	177	7	IPR001881
Domain	EGF-like_CS	SELL RELN ADAM21 F12 EYS HMCN2 LRP1 LRP4 HABP2 NOTCH4	1.99e-04	261	177	10	IPR013032
Domain	EGF	SELL F12 EYS LRP1 LRP4 HABP2 NOTCH4	2.00e-04	126	177	7	PF00008
Domain	EGF_2	SELL RELN ADAM21 F12 EYS HMCN2 LRP1 LRP4 HABP2 NOTCH4	2.25e-04	265	177	10	PS01186
Domain	FBA_I	ALDOA ALDOC	2.66e-04	3	177	2	IPR000741
Domain	S-methyl_trans	BHMT BHMT2	2.66e-04	3	177	2	PF02574
Domain	HCY	BHMT BHMT2	2.66e-04	3	177	2	PS50970
Domain	HCY_dom	BHMT BHMT2	2.66e-04	3	177	2	IPR003726
Domain	Abhydrolase_2	LYPLA2 LYPLA1	2.66e-04	3	177	2	PF02230
Domain	-	BHMT BHMT2	2.66e-04	3	177	2	3.20.20.330
Domain	Glycolytic	ALDOA ALDOC	2.66e-04	3	177	2	PF00274
Domain	Aldolase_I_AS	ALDOA ALDOC	2.66e-04	3	177	2	IPR029768
Domain	PLipase/COase/thioEstase	LYPLA2 LYPLA1	2.66e-04	3	177	2	IPR003140
Domain	ALDOLASE_CLASS_I	ALDOA ALDOC	2.66e-04	3	177	2	PS00158
Domain	Stereocilin-rel	OTOA MSLN	2.66e-04	3	177	2	IPR026664
Domain	Actin_CS	POTEF POTEE POTEI	4.28e-04	16	177	3	IPR004001
Domain	ACTINS_2	POTEF POTEE POTEI	5.16e-04	17	177	3	PS00432
Domain	-	GTF2IRD2B GTF2IRD2	5.29e-04	4	177	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	5.29e-04	4	177	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	5.29e-04	4	177	2	PF02946
Domain	Tyr_kinase_EGF/ERB/XmrK_rcpt	ERBB3 ERBB4	5.29e-04	4	177	2	IPR016245
Domain	GTF2I	GTF2IRD2B GTF2IRD2	5.29e-04	4	177	2	IPR004212
Domain	Actin/actin-like_CS	POTEF POTEE POTEI	6.15e-04	18	177	3	IPR020902
Domain	ACTINS_ACT_LIKE	POTEF POTEE POTEI	7.25e-04	19	177	3	PS01132
Domain	Growth_fac_rcpt_	ERBB3 ERBB4 EYS HMCN2 LRP1 LRP4 NOTCH4	7.26e-04	156	177	7	IPR009030
Domain	Na_trans_cytopl	SCN3A SCN8A	1.31e-03	6	177	2	PF11933
Domain	GF_recep_IV	ERBB3 ERBB4	1.31e-03	6	177	2	PF14843
Domain	GF_recep_IV	ERBB3 ERBB4	1.31e-03	6	177	2	IPR032778
Domain	Na_trans_cytopl	SCN3A SCN8A	1.31e-03	6	177	2	IPR024583
Domain	Recep_L_domain	ERBB3 ERBB4	1.82e-03	7	177	2	PF01030
Domain	Furin-like	ERBB3 ERBB4	1.82e-03	7	177	2	PF00757
Domain	Rcpt_L-dom	ERBB3 ERBB4	1.82e-03	7	177	2	IPR000494
Domain	Furin-like_Cys-rich_dom	ERBB3 ERBB4	1.82e-03	7	177	2	IPR006211
Domain	-	ERBB3 ERBB4	1.82e-03	7	177	2	3.80.20.20
Domain	EGF	SELL RELN F12 EYS LRP1 LRP4 HABP2 NOTCH4	1.84e-03	235	177	8	SM00181
Pubmed	Identification of a novel actin isoform in hepatocellular carcinoma.	POTEF POTEG POTEE POTEM POTEI	1.19e-08	15	186	5	16824795
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ARHGEF19 TMEM94 SLCO4A1 SRGAP2 MLXIP NPHP4 ITPR3 PRR12 ARHGEF40 PTPRF PER2 GLI1 SCN8A LRP4 TP53I13 OGDHL SENP2 DENND5A HERC2 BRAT1 TOP3B CBX2 BAHCC1	3.03e-08	1105	186	23	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ERBB4 USP22 KIF26B POTEF SRGAP2 STIL MLXIP NCKAP5L RUSC2 ARFGEF3 LIMK1 NF1 FAM171A2 STARD9 DYRK1B MACF1 AFDN DCLK2 ARAP2	2.16e-07	861	186	19	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TMEM94 MLXIP SMC5 RUSC2 ARFGEF3 UNC5A PER2 SRGAP3 STARD9 MACF1 SENP2 SLC39A14 ARAP2	3.43e-07	407	186	13	12693553
Pubmed	Mammalian lysophospholipases.	LYPLA2 PLA2G15 LYPLA1	6.00e-07	4	186	3	10395961
Pubmed	Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations.	SCN8A ALDOA ALDOC	1.49e-06	5	186	3	3674018
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SRGAP2 GPRIN1 PPP1CB CYFIP1 NF1 SACS SRGAP3 MACF1 DYNC1I1 PHACTR1	3.10e-06	281	186	10	28706196
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	ERBB3 ERBB4 KIF1A INCENP STIL NPHP4 PPP1CB EYS NF1 LRP1 HERC2 CBX2	3.10e-06	420	186	12	28065597
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	ERBB3 DNAH14 NF1 GLI1 DYNC1I1	5.30e-06	47	186	5	8812413
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	MYBBP1A KIF1A TMEM94 SMC5 BHMT PRR12 PHKA1 NF1 SCN8A NFRKB HERC2 TOP3B	1.07e-05	475	186	12	31040226
Pubmed	Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.	POTEE POTEM POTEI	1.23e-05	9	186	3	16364570
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TRERF1 MYBBP1A SRGAP2 PLA2G15 PPP1CB CYFIP1 NF1 FAM171A2 SRGAP3 LRP1 DGKI MACF1 AFDN HERC2 TOP3B KPNB1 PHACTR1	1.83e-05	963	186	17	28671696
Pubmed	The SIL gene is required for mouse embryonic axial development and left-right specification.	STIL GLI1 GLI3	2.41e-05	11	186	3	10385121
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	USP36 DPYD ERBB3 GRM6 PPP1CB ARFGEF3 NF1 HMCN2 MACF1 ALDOA	2.72e-05	361	186	10	26167880
Pubmed	Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.	GLI1 GLI3	2.84e-05	2	186	2	18559511
Pubmed	Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A.	ALDOA ALDOC	2.84e-05	2	186	2	3009179
Pubmed	Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori.	GLI1 GLI3	2.84e-05	2	186	2	12351188
Pubmed	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.	GLI1 GLI3	2.84e-05	2	186	2	21921029
Pubmed	Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.	ERBB3 ERBB4	2.84e-05	2	186	2	26745281
Pubmed	Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.	LYPLA2 LYPLA1	2.84e-05	2	186	2	30482805
Pubmed	A primate-specific POTE-actin fusion protein plays a role in apoptosis.	POTEF POTEE	2.84e-05	2	186	2	19669888
Pubmed	Palmar and plantar pads and flexion creases of genetic polydactyly mice (Pdn).	GLI1 GLI3	2.84e-05	2	186	2	9918099
Pubmed	Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.	GLI1 GLI3	2.84e-05	2	186	2	32114096
Pubmed	The upgraded role of HER3 and HER4 receptors in breast cancer.	ERBB3 ERBB4	2.84e-05	2	186	2	19481955
Pubmed	Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.	GLI1 GLI3	2.84e-05	2	186	2	10693759
Pubmed	AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway.	RBBP8 AUNIP	2.84e-05	2	186	2	29042561
Pubmed	Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients.	ERBB3 ERBB4	2.84e-05	2	186	2	26254096
Pubmed	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.	SRGAP2 SRGAP3	2.84e-05	2	186	2	23505444
Pubmed	[Expression and significance of ErbB3 and ErbB4 in patients with laryngeal squamous cell carcinomas].	ERBB3 ERBB4	2.84e-05	2	186	2	17969526
Pubmed	Mouse chromosomes 4 and 13 are involved in beta-carboline-induced seizures.	ESPN GLI3	2.84e-05	2	186	2	7657995
Pubmed	Characterization of the human glycerol kinase promoter: identification of a functional HNF-4alpha binding site and evidence for transcriptional activation.	HNF4A GK	2.84e-05	2	186	2	14654354
Pubmed	Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization.	BHMT BHMT2	2.84e-05	2	186	2	18457970
Pubmed	Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.	RELN ALDOA	2.84e-05	2	186	2	39227156
Pubmed	gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.	GLI1 GLI3	2.84e-05	2	186	2	8364225
Pubmed	Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria.	LYPLA2 LYPLA1	2.84e-05	2	186	2	37925639
Pubmed	Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.	ERBB3 ERBB4	2.84e-05	2	186	2	18182100
Pubmed	Sequence, expression in Escherichia coli, and characterization of lysophospholipase II.	LYPLA2 LYPLA1	2.84e-05	2	186	2	10064901
Pubmed	HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis.	ERBB3 ERBB4	2.84e-05	2	186	2	27536774
Pubmed	Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.	BHMT BHMT2	2.84e-05	2	186	2	18230605
Pubmed	Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma.	GLI1 GLI3	2.84e-05	2	186	2	25103784
Pubmed	Combination of a Sindbis-SARS-CoV-2 Spike Vaccine and αOX40 Antibody Elicits Protective Immunity Against SARS-CoV-2 Induced Disease and Potentiates Long-Term SARS-CoV-2-Specific Humoral and T-Cell Immunity.	TYR ACE2	2.84e-05	2	186	2	34394127
Pubmed	HER3 and HER4 are highly expressed in human meningiomas.	ERBB3 ERBB4	2.84e-05	2	186	2	31400925
Pubmed	The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.	BHMT NF1	2.84e-05	2	186	2	25381154
Pubmed	Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor.	IL2RA PRLR	2.84e-05	2	186	2	7588326
Pubmed	4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.	ERBB3 ERBB4	2.84e-05	2	186	2	28851073
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	2.84e-05	2	186	2	15388857
Pubmed	Enzymatic protein depalmitoylation by acyl protein thioesterases.	LYPLA2 LYPLA1	2.84e-05	2	186	2	25849916
Pubmed	Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes.	BHMT BHMT2	2.84e-05	2	186	2	26213999
Pubmed	ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery.	ERBB3 ERBB4	2.84e-05	2	186	2	19390858
Pubmed	Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes.	BHMT BHMT2	2.84e-05	2	186	2	11087663
Pubmed	Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.	BHMT BHMT2	2.84e-05	2	186	2	12818402
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	MYBBP1A ZNF484 AARS2 STARD9 GLI3 DYRK1B CCDC17 NOTCH4	3.95e-05	233	186	8	37704626
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	DPYD PLA2G15 OTUD7B PRR12 MED19 PTPRF LRP1 DGKI ALDOA	4.03e-05	303	186	9	25056061
Pubmed	Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.	GLI1 LRP1 LRP4	4.14e-05	13	186	3	16207730
Pubmed	KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice.	KIAA0586 GLI1 GLI3	4.14e-05	13	186	3	36220081
Pubmed	Lrp4 modulates extracellular integration of cell signaling pathways in development.	GLI1 GLI3 LRP4	5.25e-05	14	186	3	19116665
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	ZCCHC9 RBM26 ITPR3 ARFGEF3 SACS	7.20e-05	80	186	5	19389623
Pubmed	Mode of interactions of human aldolase isozymes with cytoskeletons.	ALDOA ALDOC	8.50e-05	3	186	2	9244396
Pubmed	Aldolase positively regulates of the canonical Wnt signaling pathway.	ALDOA ALDOC	8.50e-05	3	186	2	24993527
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI3	8.50e-05	3	186	2	26010061
Pubmed	Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development.	ERBB3 ERBB4	8.50e-05	3	186	2	12112465
Pubmed	Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.	BHMT BHMT2	8.50e-05	3	186	2	25846410
Pubmed	Hypoxia-Associated Factor (HAF) Mediates Neurofibromin Ubiquitination and Degradation Leading to Ras-ERK Pathway Activation in Hypoxia.	F12 NF1	8.50e-05	3	186	2	30705246
Pubmed	Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.	BHMT BHMT2	8.50e-05	3	186	2	29356306
Pubmed	Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.	ERBB4 PRLR	8.50e-05	3	186	2	12954715
Pubmed	ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.	ERBB3 ERBB4	8.50e-05	3	186	2	30637799
Pubmed	erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.	ERBB3 ERBB4	8.50e-05	3	186	2	9851845
Pubmed	Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse.	TYR HERC2	8.50e-05	3	186	2	5565073
Pubmed	Brachyphalangy, an allele of extra-toes in the mouse.	GLI1 GLI3	8.50e-05	3	186	2	5806166
Pubmed	A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.	TYR NF1	8.50e-05	3	186	2	12427839
Pubmed	DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.	GLI1 DYRK1B	8.50e-05	3	186	2	26784250
Pubmed	Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.	GLI1 KPNB1	8.50e-05	3	186	2	24854174
Pubmed	The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.	ERBB3 ERBB4	8.50e-05	3	186	2	28304405
Pubmed	Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p.	SENP2 KPNB1	8.50e-05	3	186	2	27939291
Pubmed	Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.	GLI1 GLI3	8.50e-05	3	186	2	28965847
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI3	8.50e-05	3	186	2	9178901
Pubmed	Expression and significance of HER family receptors in neuroblastic tumors.	ERBB3 ERBB4	8.50e-05	3	186	2	21203803
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI3	8.50e-05	3	186	2	8378770
Pubmed	Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1.	HNF4A ACE2	8.50e-05	3	186	2	38375778
Pubmed	New evidence for the role of cystathionine beta-synthase in non-syndromic cleft lip with or without cleft palate.	BHMT BHMT2	8.50e-05	3	186	2	21564312
Pubmed	High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.	ERBB3 ERBB4	8.50e-05	3	186	2	24901400
Pubmed	HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.	HNF4A PER2	8.50e-05	3	186	2	34732735
Pubmed	Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle.	LYPLA2 LYPLA1	8.50e-05	3	186	2	29733200
Pubmed	Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.	GLI1 GLI3	8.50e-05	3	186	2	24311597
Pubmed	Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4).	ERBB3 ERBB4	8.50e-05	3	186	2	28653892
Pubmed	Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.	GLI1 GLI3	8.50e-05	3	186	2	10075717
Pubmed	SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.	STIL GLI1	8.50e-05	3	186	2	18829525
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI3	8.50e-05	3	186	2	8387379
Pubmed	NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis.	SELL TYR	8.50e-05	3	186	2	18385071
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI3	8.50e-05	3	186	2	16571352
Pubmed	The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.	GLI1 GLI3	8.50e-05	3	186	2	29722127
Pubmed	An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels.	ERBB3 ERBB4	8.50e-05	3	186	2	11867753
Pubmed	Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells.	ERBB3 ERBB4	8.50e-05	3	186	2	22891299
Pubmed	Palmitoylation couples insulin hypersecretion with β cell failure in diabetes.	LYPLA2 LYPLA1	8.50e-05	3	186	2	36634673
Pubmed	Influence of thyroxine and thyroxine with growth hormone and prolactin on splenocyte subsets and on the expression of interleukin-2 and prolactin receptors on splenocyte subsets of Snell dwarf mice.	IL2RA PRLR	8.50e-05	3	186	2	7568281
Pubmed	Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.	ERBB3 ERBB4	8.50e-05	3	186	2	7689552
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI3	8.50e-05	3	186	2	22178118
Pubmed	ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma.	ERBB3 ERBB4	8.50e-05	3	186	2	23333248
Pubmed	Expression and potential role of ErbB receptors in type II endometrial cancer.	ERBB3 ERBB4	8.50e-05	3	186	2	23395558
Pubmed	Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.	NECTIN4 AFDN	8.50e-05	3	186	2	32554531
Cytoband	7q11.23	LIMK1 GTF2IRD2B RCC1L STAG3L1 GTF2IRD2	4.93e-05	97	186	5	7q11.23
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEF POTEG POTEE POTEM POTEI	1.18e-08	13	115	5	685
GeneFamily	Ankyrin repeat domain containing	ESPN POTEF POTEG BCORL1 POTEE POTEM ASB16 ANKEF1 DGKI POTEI NOTCH4 ARAP2	4.60e-08	242	115	12	403
GeneFamily	Erb-b2 receptor tyrosine kinases	ERBB3 ERBB4	2.39e-04	4	115	2	1096
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN3A SCN8A	1.40e-03	9	115	2	1203
ToppCell	droplet-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM HNF4A ACSL1 GK PTPRF GALNT11 HABP2 SARDH PRLR	9.78e-08	187	186	9	236e9857729670e87eed30fad58f49e1f56e4a85
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DPYD SRGAP2 ACSL1 UNC5A ARHGEF40 GK LRP1 IL17RA PHACTR1	1.59e-07	198	186	9	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DPYD SRGAP2 ACSL1 UNC5A ARHGEF40 GK LRP1 IL17RA PHACTR1	1.59e-07	198	186	9	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	droplet-Liver-Hepatocytes-21m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD ARHGEF19 F12 BHMT PTPRF BHMT2 SARDH PRLR	4.62e-07	164	186	8	90afae3cca108ebfb44ff2ec4adcbb8c68a0bdf2
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLCO4A1 HNF4A BHMT ACE2 GREB1 USH2A PRLR SLC23A3	1.06e-06	183	186	8	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD ERBB3 ARHGEF19 F12 ACSL1 PTPRF HABP2 SARDH	1.06e-06	183	186	8	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF4A BHMT ACSL1 GK GALNT11 HABP2 SARDH PRLR	1.10e-06	184	186	8	c86ed59fed687cdaaf7e9c4418d2e3e2c4111cca
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF4A BHMT ACSL1 GK GALNT11 HABP2 SARDH PRLR	1.10e-06	184	186	8	7c256bcfa07c5ff55aad0833e8712b0456b5832b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ESPN HNF4A BHMT ACE2 GALNT11 GREB1 PRLR SLC23A3	1.52e-06	192	186	8	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ERBB3 SOBP POTEF HNF4A DNAH14 SCN8A AFDN GREB1	1.58e-06	193	186	8	503a979328c68b096680b71359a26f02fafdff35
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ESPN ONECUT2 KIF1A PON3 RTBDN SCN3A DGKI GREB1	1.58e-06	193	186	8	25b1e5a04724023918c8939109a92b35582d5e5c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPYD NEURL2 SRGAP2 PRSS36 ACSL1 LRP1 IL2RA PHACTR1	1.64e-06	194	186	8	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ERBB3 KIF1A KIF26B HNF4A ITPR3 PTPRF HABP2 MSLN	2.06e-06	200	186	8	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD HNF4A F12 BHMT ACSL1 PTPRF SARDH	2.88e-06	147	186	7	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 DPYD F12 BHMT ACSL1 SARDH PRLR	3.44e-06	151	186	7	cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD HNF4A F12 ACSL1 PTPRF HABP2 SARDH	4.27e-06	156	186	7	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	TCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11\|TCGA-Brain / Sample_Type by Project: Shred V9	DPYD POTEF POTEG POTEE POTEI	6.62e-06	63	186	5	d7dc1356a60cb527fe668328d5375f352239d911
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM GK SLC22A13 BHMT2 USH2A PRLR SLC23A3	6.68e-06	167	186	7	ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCell	droplet-Kidney-nan-18m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM GK SLC22A13 BHMT2 USH2A PRLR SLC23A3	7.22e-06	169	186	7	f00741203efa0b948db7223ee8c19bdd0918258a
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM GK GALNT11 SLC22A13 BHMT2 PRLR SLC23A3	9.07e-06	175	186	7	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM GK GALNT11 SLC22A13 BHMT2 PRLR SLC23A3	9.07e-06	175	186	7	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	facs-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM ACSL1 GK GALNT11 SLC22A13 SARDH PRLR	9.77e-06	177	186	7	7f58286fc8797e9bdcf8ece0849f55680905955d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESPN GPR155 HNF4A BHMT ACSL1 BHMT2 PRLR	1.05e-05	179	186	7	78fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD ERBB3 ARHGEF19 F12 PTPRF HABP2 SARDH	1.17e-05	182	186	7	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	droplet-Kidney-nan-21m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM ACSL1 PTPRF GCAT SLC22A13 SARDH PRLR	1.17e-05	182	186	7	942c18a27b22fb33a5200d5717cad972f3ef0576
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD ERBB3 ARHGEF19 F12 PTPRF HABP2 SARDH	1.17e-05	182	186	7	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD ERBB3 ARHGEF19 F12 PTPRF HABP2 SARDH	1.17e-05	182	186	7	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	BCORL1 DGKI DCLK2 LGR6 CNN1 DYNC1I1 MSLN	1.17e-05	182	186	7	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF4A ACSL1 GK GALNT11 HABP2 SARDH PRLR	1.26e-05	184	186	7	3d7dd193a0826cc7a4e454a29236a16c315e5965
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF4A ACSL1 GK GALNT11 HABP2 SARDH PRLR	1.26e-05	184	186	7	45577ff91c3b2b303acd97239dde2463ea7a429c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESPN GPR155 HNF4A BHMT ACE2 BHMT2 PRLR	1.26e-05	184	186	7	9434731f651820b05335085582960f08fbf895de
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ERBB3 RELN HNF4A ANKEF1 LRP1 GREB1 SLC39A14	1.30e-05	185	186	7	1d874608aa2062024323512f68889219471b2f00
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF1A GPRIN1 F12 ARFGEF3 SCN3A BHMT2 DYNC1I1	1.35e-05	186	186	7	24b23880d4ff8fb4a23e2012d5890b9e2fcf7283
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KIF1A RBM26 ARFGEF3 PTPRF PRLR PHACTR1	1.44e-05	188	186	7	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	Control\|World / Disease state, Lineage and Cell class	MAMLD1 PPARD ACSL1 GK DGKI DENND5A PHACTR1	1.49e-05	189	186	7	fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC-PNEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ESPN ONECUT2 KIF1A PON3 RTBDN SCN3A GREB1	1.60e-05	191	186	7	146cfd4daa2878536b4f381564c787919ad855a8
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KIF1A RBM26 ARFGEF3 PTPRF PRLR PHACTR1	1.60e-05	191	186	7	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-PNEC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ESPN ONECUT2 KIF1A PON3 RTBDN SCN3A GREB1	1.60e-05	191	186	7	12ea07565dc0e62cade9fbab4a2d763e47a341e3
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN KIF1A RBM26 ARFGEF3 PTPRF PRLR PHACTR1	1.60e-05	191	186	7	a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCell	Fetal_29-31_weeks-Epithelial\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ERBB3 ERBB4 DNAH14 ITPR3 ARFGEF3 PTPRF PHACTR1	1.71e-05	193	186	7	a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HNF4A BHMT ACE2 GCAT GALNT11 BHMT2 SLC23A3	1.89e-05	196	186	7	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ESPN ONECUT2 ERBB3 HNF4A ACE2 GK SLC39A14	2.02e-05	198	186	7	ecdef1a0a0b8399e193b922c8ca8c25e63de4a4f
ToppCell	droplet-Liver-nan-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD F12 BHMT ACSL1 SARDH PRLR	4.17e-05	151	186	6	7758cfbe8dca849c90bd6e8bc63310e53beeb8fd
ToppCell	droplet-Liver-nan-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD F12 BHMT ACSL1 SARDH PRLR	4.17e-05	151	186	6	b4a0546c1573b4b2290890307f2a5daf3a7cbb37
ToppCell	facs-Aorta-Heart-24m-Myeloid\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 SELL NEURL2 NUBP1 RCC1L GCAT	5.56e-05	159	186	6	443f6df4a88fa8755adcde4cc12575dff614ecb4
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD F12 BHMT BHMT2 SARDH PRLR	5.76e-05	160	186	6	8de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DBF4B PON3 GK SARDH INCA1 IL2RA	5.76e-05	160	186	6	c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 PHKA1 LIMK1 DYRK1B SARDH ALDOC	5.96e-05	161	186	6	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	Club-club-13\|World / Class top	MBD3L1 ONECUT2 ACSL1 ACE2 MSLN SLC23A3	6.17e-05	162	186	6	7d18f05a65ac715e62d610df9cc4a26539340dee
ToppCell	droplet-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPYD F12 BHMT BHMT2 SARDH PRLR	6.39e-05	163	186	6	a794540f2d8984f963c08f05175e4bc916fcc224
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 F12 BHMT BHMT2 SARDH PRLR	6.39e-05	163	186	6	03d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCell	droplet-Liver-Hepatocytes-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 F12 BHMT BHMT2 SARDH PRLR	6.39e-05	163	186	6	1c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GLI3 SCN3A BHMT2 CACNA1I CNN1 DYNC1I1	7.06e-05	166	186	6	26f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM HNF4A GK BHMT2 LYPLA1 NIT1	7.55e-05	168	186	6	624cf8f439c0a3c877927e085ec260ca79896b5a
ToppCell	Pericytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	BHMT GLI1 DGKI LGR6 CNN1 DYNC1I1	8.32e-05	171	186	6	bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell	10x5'-Liver-Myeloid_Mac-Intermediate_macrophages\|Liver / Manually curated celltypes from each tissue	TRIM72 ACSL1 GK DENND5A PRLR PHACTR1	8.32e-05	171	186	6	25e0333743affdb662223fb5220b8a61fa02ad9f
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 PIR ARFGEF3 PTPRF SRGAP3 SCN3A	8.59e-05	172	186	6	30916a902c151907745756d14327e24adc34afef
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	KIF1A SLCO4A1 SCN3A DGKI DCLK2 PRLR	8.87e-05	173	186	6	e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	GPR155 ONECUT2 DBF4B SLCO4A1 PRSS36	9.04e-05	108	186	5	ee924deacd14ea404fda80ed633960143fd474c0
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR155 ONECUT2 RELN PON3 INCA1 PRLR	9.45e-05	175	186	6	28b29f844fa46fe579ddc19039fb2d9dc5f48f3b
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RTBDN POTEE UNC5A EYS SCN3A POTEI	9.45e-05	175	186	6	182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-plasma_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR155 ONECUT2 RELN PON3 INCA1 PRLR	9.45e-05	175	186	6	ac96ca9ca309b0d72a2f5af6a3b02c7f80755750
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ERBB3 RELN POTEF HNF4A ANKEF1 PRLR	9.75e-05	176	186	6	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	droplet-Kidney-nan-21m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACADM ACSL1 PTPRF SLC22A13 SARDH PRLR	9.75e-05	176	186	6	0475db3f860de1e216cbdeb886f7a75b9f4fc801
ToppCell	390C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	SARM1 PON3 STIL TCL1A DYRK1B NOTCH4	9.75e-05	176	186	6	aab9603b7943b7f7243eb6190ebba998566196f3
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GPR155 HNF4A BHMT BHMT2 GREB1 PRLR	1.01e-04	177	186	6	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	facs-Brain_Myeloid-Striatum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR155 CYFIP1 FER1L4 MACF1 ALDOA PRLR	1.01e-04	177	186	6	efb1990fd1d216f64261e81017299783afb24a1e
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 SELL KIAA0586 GTF2IRD2 BRAT1 BAHCC1	1.04e-04	178	186	6	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RELN UNC5A SCN3A BHMT2 MACF1 AFDN	1.04e-04	178	186	6	ad3de3e03a401dac64431a541899445262246347
ToppCell	15-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	ESPN KIF1A HNF4A ACSL1 ARFGEF3 SCN3A	1.07e-04	179	186	6	bc04789f0fbd293fdcea66acba8cf227af251b7a
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	USP36 OTOA PPARD PRSS36 ARFGEF3 SRGAP3	1.10e-04	180	186	6	ba4c1fb55e8f1095bea6968417fefcf5f700926b
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BHMT ACSL1 GALNT11 HABP2 SARDH PRLR	1.14e-04	181	186	6	bec7076efe94898213a62db72d171d737949977e
ToppCell	facs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BHMT ACSL1 GALNT11 HABP2 SARDH PRLR	1.14e-04	181	186	6	cf149b30b814cf87c9e923ef502cadf7fe4a3597
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ONECUT2 KIF1A BHMT ACSL1 ARFGEF3 USH2A	1.14e-04	181	186	6	cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ONECUT2 ERBB3 HNF4A HABP2 SLC23A3	1.17e-04	114	186	5	b350140b389f8762c77a37df473081e1127a8972
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	ONECUT2 KIF1A SCN3A SCN8A POTEI DYNC1I1	1.17e-04	182	186	6	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESPN HNF4A BHMT ACE2 GREB1 PRLR	1.17e-04	182	186	6	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAM21 SMC5 GPRIN1 ACE2 GK SCN3A	1.17e-04	182	186	6	eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ONECUT2 KIF1A HNF4A ACSL1 ARFGEF3 POTEI	1.21e-04	183	186	6	8820cfed27b292bc0bc9cde4005219ed41900552
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLCO4A1 GLI1 GLI3 GREB1 LGR6 ALDOC	1.21e-04	183	186	6	99bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ONECUT2 RELN KIF26B ARFGEF3 USH2A	1.24e-04	184	186	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT18 OTUD7B PTPRF AFDN ARAP2 PHACTR1	1.24e-04	184	186	6	57c792e6e2fedba25d3350ffe649fd74750b579d
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	SELL DPYD PPARD PPP1CB ACSL1 GK	1.24e-04	184	186	6	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ONECUT2 RELN KIF26B ARFGEF3 USH2A	1.24e-04	184	186	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA ONECUT2 RELN KIF26B ARFGEF3 USH2A	1.24e-04	184	186	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	GPR155 HNF4A BHMT ACE2 BHMT2 PRLR	1.24e-04	184	186	6	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GALNT18 OTUD7B PTPRF AFDN ARAP2 PHACTR1	1.24e-04	184	186	6	d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TRIM72 ESPN OTOA C4orf54 SLC23A3	1.27e-04	116	186	5	9c92e714e210a2f29a9e228653d4c990ec643c72
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF4A GK GALNT11 HABP2 SARDH PRLR	1.28e-04	185	186	6	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HNF4A GK GALNT11 HABP2 SARDH PRLR	1.28e-04	185	186	6	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RNF144A SRGAP2 ITPR3 PRR12 GLI1 GREB1	1.28e-04	185	186	6	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RNF144A SRGAP2 ITPR3 PRR12 GLI1 GREB1	1.28e-04	185	186	6	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 KIF1A RTBDN ACE2 SCN3A SCN8A	1.28e-04	185	186	6	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KIF26B MAMLD1 PPARD GALNT18 DCLK2 CNN1	1.28e-04	185	186	6	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ERBB3 ERBB4 DNAH14 ARFGEF3 CD47 PHACTR1	1.32e-04	186	186	6	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ESPN ONECUT2 KIF1A ARFGEF3 SCN3A HABP2	1.32e-04	186	186	6	c7983281a290201567b398e9ea6baddb96c692bb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESPN HNF4A BHMT ACE2 GREB1 PRLR	1.32e-04	186	186	6	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	mild-unassigned\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ARHGEF19 ARHGEF40 GK SRGAP3 LGR6 PHACTR1	1.32e-04	186	186	6	5b2e1a58916f392fa1156bf9210df528775248ff
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SOBP HNF4A BHMT BHMT2 SLC39A14 PRLR	1.32e-04	186	186	6	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	droplet-Tongue-nan-24m-Epithelial-parabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSL1 ACE2 GCAT NECTIN4 AFDN ALDOC	1.32e-04	186	186	6	18c06041c6c8a0ebac17b3c8aaebd67e652d315a
Disease	Malignant neoplasm of breast	TRERF1 DPYD ERBB3 ERBB4 ACADM BCORL1 ARTN GRM6 NF1 LLGL1 PER2 SRGAP3 GLI1 ANKEF1 ACCS MACF1 LGR6 HERC2 KAT6B ALDOA L3MBTL3 CPSF3 NOTCH4	9.83e-08	1074	174	23	C0006142
Disease	Malignant neoplasm of skin	ERBB3 ERBB4 PPARD TYR NOTCH4	2.60e-05	59	174	5	C0007114
Disease	Skin Neoplasms	ERBB3 ERBB4 PPARD TYR NOTCH4	2.60e-05	59	174	5	C0037286
Disease	mesothelin measurement	SARM1 MSLN	2.06e-04	4	174	2	EFO_0020565
Disease	Peripheral Nervous System Diseases	DPYD PPARD GLI1 DYNC1I1	2.94e-04	54	174	4	C4721453
Disease	Intellectual Disability	TMEM94 PRR12 ACE2 NF1 SACS SRGAP3 SCN3A SCN8A MACF1 PHACTR1	3.42e-04	447	174	10	C3714756
Disease	migraine without aura	LRP1 PHACTR1	3.42e-04	5	174	2	MONDO_0100431
Disease	Noonan Syndrome	PPP1CB NF1 KAT6B	3.72e-04	24	174	3	C0028326
Disease	Breast Carcinoma	TRERF1 DPYD ERBB3 ERBB4 ARTN LLGL1 LGR6 HERC2 ALDOA L3MBTL3 NOTCH4	3.72e-04	538	174	11	C0678222
Disease	CD63 antigen measurement	SARM1 F12	5.11e-04	6	174	2	EFO_0022033
Disease	Common Migraine	LRP1 PHACTR1	7.12e-04	7	174	2	C0338480
Disease	Polysyndactyly	GLI3 LRP4	7.12e-04	7	174	2	C0265553
Disease	cysteine-rich with EGF-like domain protein 1 measurement	TATDN2 SRGAP2 SRGAP3	8.81e-04	32	174	3	EFO_0021870
Disease	bone morphogenetic protein 6 measurement	SARM1 F12	9.46e-04	8	174	2	EFO_0020186
Disease	pain	NUDT18 ONECUT2 RBBP8 LRP1 MACF1 PHACTR1	1.12e-03	196	174	6	EFO_0003843
Disease	pulse pressure measurement, migraine without aura, susceptibility to, 4	LRP1 PHACTR1	1.21e-03	9	174	2	EFO_0005763, MONDO_0011847
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI3	1.21e-03	9	174	2	DOID:0050338 (implicated_via_orthology)
Disease	tumor necrosis factor receptor superfamily member 16 measurement	SARM1 F12	1.21e-03	9	174	2	EFO_0802168
Disease	alcohol use disorder measurement, longitudinal alcohol consumption measurement	SCN8A DCLK2 BAHCC1	1.35e-03	37	174	3	EFO_0007645, EFO_0009458
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN3A SCN8A	1.51e-03	10	174	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN3A SCN8A	1.51e-03	10	174	2	DOID:0080422 (implicated_via_orthology)
Disease	hair colour measurement, eye colour measurement, skin pigmentation measurement	TYR HERC2	1.51e-03	10	174	2	EFO_0007009, EFO_0007822, EFO_0009764
Disease	feeling nervous measurement	DPYD DNAH14 NF1 NOTCH4	1.78e-03	87	174	4	EFO_0009597
Disease	vascular endothelial growth factor D measurement	PIR F12	1.84e-03	11	174	2	EFO_0010575
Disease	pigmentation disease (is_implicated_in)	TYR HERC2	1.84e-03	11	174	2	DOID:10123 (is_implicated_in)
Disease	gallbladder neoplasm	ERBB3 ERBB4	1.84e-03	11	174	2	C0016978
Disease	gastrin-releasing peptide measurement	SARM1 HABP2	1.84e-03	11	174	2	EFO_0022000
Disease	Malignant neoplasm of gallbladder	ERBB3 ERBB4	1.84e-03	11	174	2	C0153452
Disease	diffuse plaque measurement	ONECUT2 RELN ERBB4 KIF26B GALNT18 DNAH14 ARFGEF3 EYS ACCS MACF1 KAT6B NOTCH4	1.88e-03	758	174	12	EFO_0010699
Disease	age-related macular degeneration	TYR GLI3 HERC2 NOTCH4	1.93e-03	89	174	4	EFO_0001365
Disease	occupational attainment	ERBB4 PTPRF CD47	1.95e-03	42	174	3	EFO_0020977
Disease	lipid measurement, lipoprotein measurement	PPARD HNF4A LLGL1 KPNB1	2.01e-03	90	174	4	EFO_0004529, EFO_0004732
Disease	hepatocellular carcinoma (is_marker_for)	ERBB3 BCORL1 HNF4A BHMT BHMT2 SARDH CBX2	2.14e-03	301	174	7	DOID:684 (is_marker_for)
Disease	Bipolar Disorder	ERBB3 RELN ERBB4 PPARD PER2 STARD9 SCN8A CD47 NOTCH4	2.19e-03	477	174	9	C0005586
Disease	persulfide dioxygenase ETHE1, mitochondrial measurement	SARM1 F12	2.19e-03	12	174	2	EFO_0008258
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN3A SCN8A	2.19e-03	12	174	2	DOID:0060170 (implicated_via_orthology)
Disease	homostachydrine measurement	ERBB4 EYS	2.58e-03	13	174	2	EFO_0021164
Disease	FVC change measurement, response to placebo	RELN KIF1A	2.58e-03	13	174	2	EFO_0008344, EFO_0010339
Disease	transmembrane protein 87B measurement	SARM1 F12	2.58e-03	13	174	2	EFO_0802158
Disease	tRNA (guanine-N(7)-)-methyltransferase measurement	SARM1 F12	2.58e-03	13	174	2	EFO_0802162
Disease	hematocrit	RNF144A BCORL1 MAMLD1 HNF4A ITPR3 PRR12 ARHGEF40 AUNIP LLGL1 ASB16 TRMT61B L3MBTL3 NOTCH4 BAHCC1	2.77e-03	1011	174	14	EFO_0004348
Disease	actinic keratosis	TYR HERC2	3.00e-03	14	174	2	EFO_0002496
Disease	median neuropathy (biomarker_via_orthology)	ERBB3 ERBB4	3.00e-03	14	174	2	DOID:571 (biomarker_via_orthology)
Disease	asthma, body mass index	USP36 ERBB3	3.00e-03	14	174	2	EFO_0004340, MONDO_0004979
Disease	pancreatic cancer (is_marker_for)	DPYD ARTN PPARD MSLN	3.06e-03	101	174	4	DOID:1793 (is_marker_for)
Disease	asthma, chronic obstructive pulmonary disease	ERBB3 KCNJ18 IL2RA	3.22e-03	50	174	3	EFO_0000341, MONDO_0004979
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	HNF4A LLGL1 LRP4 MACF1	3.28e-03	103	174	4	EFO_0008595, EFO_0020944
Disease	amyotrophic lateral sclerosis, age at onset	PTPRF ARAP2	3.45e-03	15	174	2	EFO_0004847, MONDO_0004976
Disease	melanoma	ERBB4 INCENP PPARD BATF2 TYR NF1	3.63e-03	248	174	6	C0025202
Disease	Abnormal behavior	BCORL1 PRR12	3.93e-03	16	174	2	C0233514
Disease	migraine without aura, susceptibility to, 4	LRP1 PHACTR1	3.93e-03	16	174	2	MONDO_0011847
Disease	IGFBP-3 measurement	ERBB3 GREB1 NOTCH4	4.01e-03	54	174	3	EFO_0004626
Disease	Mammary Carcinoma, Human	TRERF1 DPYD ERBB3 ARTN LLGL1 LGR6 ALDOA L3MBTL3 NOTCH4	4.11e-03	525	174	9	C4704874
Disease	Mammary Neoplasms, Human	TRERF1 DPYD ERBB3 ARTN LLGL1 LGR6 ALDOA L3MBTL3 NOTCH4	4.11e-03	525	174	9	C1257931
Disease	Mammary Neoplasms	TRERF1 DPYD ERBB3 ARTN LLGL1 LGR6 ALDOA L3MBTL3 NOTCH4	4.21e-03	527	174	9	C1458155
Disease	factor VII activating protease measurement	ONECUT2 HABP2 METTL25	4.22e-03	55	174	3	EFO_0009368
Disease	Glycogen storage disease	PHKA1 ALDOA	4.44e-03	17	174	2	cv:C0017919
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 GLI3	4.44e-03	17	174	2	DOID:0060071 (biomarker_via_orthology)
Disease	cervical artery dissection	LRP1 PHACTR1	4.44e-03	17	174	2	EFO_1000059
Disease	Autistic Disorder	GPR155 DPYD RELN KIF1A NF1 PRLR	4.65e-03	261	174	6	C0004352
Disease	autoimmune thyroid disease, Hashimoto's thyroiditis, Graves disease	PRSS36 IL2RA	4.97e-03	18	174	2	EFO_0003779, EFO_0004237, EFO_0006812
Disease	asthma	USP36 ERBB3 RBBP8 SRGAP2 SRGAP3 GLI3 LRP1 SARDH METTL25 IL2RA NOTCH4	5.15e-03	751	174	11	MONDO_0004979
Disease	skin sensitivity to sun	TYR HERC2	5.53e-03	19	174	2	EFO_0004795
Disease	laryngeal squamous cell carcinoma (is_marker_for)	ERBB3 ERBB4	5.53e-03	19	174	2	DOID:2876 (is_marker_for)
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	HNF4A LLGL1 LRP4 MACF1	5.81e-03	121	174	4	EFO_0008595, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
VAATMCIGPEGDLHG	BHMT	181	Q93088
FGPGIQPHHCDLTNM	AFDN	441	P55196
PMPRGCLASESSEGH	ERBB3	1086	P21860
KMEDGLLTCHGPGPD	ERBB4	561	Q15303
NSHPGIDRPGMLCSF	DCAF4	266	Q8WV16
ALSCLGPTHMGPLAL	BRAT1	286	Q6PJG6
SCPGDLAPHLMMQSG	BAHCC1	791	Q9P281
MDSHSGEPALLPCGT	CCDC17	1	Q96LX7
CMAGHTGPEGPLSDT	ARHGEF40	481	Q8TER5
TQGPMSPLGDELYHC	RBBP8	271	Q99708
CGIHPGLEGMDALPY	CPSF3	41	Q9UKF6
LGPTCMQDLGSSHGE	ACCS	16	Q96QU6
GSCLHNPPRLGEIFM	ADAM21	391	Q9UKJ8
GTLLKPNMVTPGHAC	ALDOC	226	P09972
LGMQHDEFPCTCPSG	ADAM7	341	Q9H2U9
TAGHVGAPMPCNLIK	ACSL1	476	P33121
GTLLKPNMVTPGHAC	ALDOA	226	P04075
HLCSDSTPKMEGPQG	BCORL1	956	Q5H9F3
EVPNGAGHTPMDCAL	ASB16	311	Q96NS5
GAHPDVQDRMGCTPT	ANKEF1	71	Q9NU02
GADALELNLSCPHGM	DPYD	661	Q12882
ADVMCATGDPVHSTP	ARAP2	836	Q8WZ64
LMNTHIPENCGGLGL	ACADM	86	P11310
LPEVMGSDHCPVGAV	APEX2	296	Q9UBZ4
PELMDVSLVGGPADC	DYRK1B	561	Q9Y463
TMPGEPVDVACGVDH	RCC1L	441	Q96I51
GDMCPFDHGSDPVVV	RBM26	306	Q5T8P6
MAGPAEEAGAHCPES	TP53I13	26	Q8NBR0
GLVEATMPPGVQLHC	PLA2G15	316	Q8NCC3
PLGMPHGAAAFVDTC	ITPR3	2411	Q14573
PGHSNPEVLMDCGVD	KAT6B	1466	Q8WYB5
CTLHPNDSLAMEGPL	LLGL1	636	Q15334
PLELMEASEHGGCST	L3MBTL3	546	Q96JM7
PPTTGGAELMCQDLE	NUBP1	246	P53384
MDCGPPATLQPHLTG	ARHGEF19	1	Q8IW93
LEDLASGLEHSCPMP	MBD3L1	106	Q8WWY6
DPMPGCHGVVAPSSD	OTOA	821	Q7RTW8
GGSNEHPLEMPICAF	OTUD7B	121	Q6GQQ9
GPLPSNGVMHVDECV	CYFIP1	1111	Q7L576
CALMLLEHGTDPNIP	POTEF	221	A5A3E0
GGCSRPAMVLTDPHT	IL17RA	766	Q96F46
ESCLPGAHGMGSQPS	GLI3	1361	P10071
DPCMNGGLCHESTIP	EYS	816	Q5T1H1
HMLTDPLELGPCGDG	NFRKB	6	Q6P4R8
DDGSMEPGTCQELLH	NCKAP5L	21	Q9HCH0
EGLPCILIFSGMDPH	GREB1	1021	Q4ZG55
MGTTAPGPIHLLELC	INCENP	1	Q9NQS7
VGTVGMPHLPVTACG	NUDT18	206	Q6ZVK8
PAPCHCQEDGIMLSA	LGR6	36	Q9HBX8
SMGNGELHCPSIEPI	GPR155	596	Q7Z3F1
MELVPSIHPGVTCDG	HERC2	2696	O95714
SIHPGVTCDGCQMFP	HERC2	2701	O95714
TPGAPMELLCDAQGT	HMCN2	3516	Q8NDA2
SCCTHLSFMDPGPEG	PHKA1	611	P46020
CSCPLGMELGPDNHT	LRP1	1206	Q07954
MELGLGGLSTLSHCP	ARTN	1	Q5T4W7
MVGLHTCGDLAPNTL	METTL25	381	Q8N6Q8
DGCEMALPGLATQSP	KIF26B	1511	Q2KJY2
CPGETLAARPGMAHS	ESPN	526	B1AK53
GVHCVMSLGVPGPAT	FLYWCH2	61	Q96CP2
SLMLTAPGAAPGEVC	FER1L4	701	A9Z1Z3
PVTGINCHMAVGPID	DYNC1I1	486	O14576
SPVHPALFACVDGMG	DYNC1I1	541	O14576
HCQDSGRPGMEPISP	DCLK2	706	Q8N568
SQVPSQGPCVHMEAG	C9orf131	896	Q5VYM1
QEMLLGGSPSDAPHA	HNF4A	371	P41235
QLLMSSEGHPCGADV	PER2	156	O15055
CPATGIPEDMLTHIG	OGDHL	591	Q9ULD0
MNSLLEGGPGQTPLC	CSKMT	116	A8MUP2
DPPRLMKCHGSGGSQ	GALNT11	546	Q8NCW6
GRGILHAEMPCSEEP	PIR	96	O00625
NPELTMESLGTLHGP	ONECUT2	21	O95948
HPLGDTACTVEMPPL	MACF1	276	O94854
EAPELGTMDCTHPLG	SELL	201	P14151
PLSAPDLGIMNCSHP	SELL	261	P14151
VQPCGPHDSARGGMI	GLI1	151	P08151
MQEALSGTPCLLGPG	MSLN	601	Q13421
ISGASHPICPVMLGD	GCAT	341	O75600
GVLFCPRPDGTADMH	NEURL2	191	Q9BR09
PSHMPTGPQAASCLD	MYBBP1A	956	Q9BQG0
VGMLGEDPPVHVRCS	NPHP4	1161	O75161
HPGQGCPETMPITFL	RNF144A	151	P50876
GTECHPEAALPSTIM	RELN	1056	P78509
HTTPSMCLNPDLEGP	PCBP2	211	Q15366
PRVCSGEGPHKTDLM	PCDHA13	756	Q9Y5I0
GSLPMHPSGCRMIDE	PHACTR1	301	Q9C0D0
APHAMISSCGTIPGN	PROSER1	131	Q86XN7
MSQLHLICGGPLEPA	FAM171A2	371	A8MVW0
QATDRGPVPMAGHCK	PCDHAC2	336	Q9Y5I4
CALMLLEHGTDPNIP	POTEE	221	Q6S8J3
CHGGLSPDLQSMEQI	PPP1CB	171	P62140
MVPGSRPCHGALVSE	PRSS36	341	Q5K4E3
PTAPSLAHMDEQGCE	MLXIP	386	Q9HAP2
PLTISMPQGHFCGGA	HABP2	336	Q14520
EACPGDMRPTPNHTG	GRM6	556	O15303
MVQPLGFHAPDCGKE	BHMT2	236	Q9H2M3
ACGGPSAMATPENLA	CBX2	221	Q14781
MDSSGLGPCSEAPLH	DOCK8-AS1	91	Q5T8R8
SLDGVMGPPASHTCV	DBF4B	411	Q8NFT6
MDAAGRGCHLLPLPA	DGKI	1	O75912
MHLCGGNGLLTQTDP	BATF2	1	Q8N1L9
ILSVGLEMGSHNPDC	ARFGEF3	996	Q5TH69
LSGDNGIMGCHEIPP	CACNA1I	271	Q9P0X4
MGPASCGGRSLHLPQ	TMEM132E-DT	16	A2RUQ5
GPDTENVPIMYICHG	GALNT18	486	Q6P9A2
SVPTLLCMGDDLQGH	CALHM4	276	Q5JW98
CGIPLSHLQVDGGMT	GK	421	P32189
ISPIGCLPAHLLGDM	ACE2	256	Q9BYF1
MAFGIPPEGNLHCSE	DENND5A	416	Q6IQ26
MEALHLNLGGCPAGP	DNAH14	1151	Q0VDD8
SPMQPVDQASLPGHC	IL2RA	111	P01589
PCLEDVTLAMGPGAH	MAMLD1	86	Q13495
VTLAMGPGAHPSTAC	MAMLD1	91	Q13495
AVMAFGCILEGPEPS	KPNB1	386	Q14974
LEVATLGQGPDCPSM	GLMP	236	Q8WWB7
GDCDPLVPLMFGSLT	LYPLA1	171	O75608
CHGELDPMVPVRFGA	LYPLA2	171	O95372
AACIPMHGPLLISGL	CD47	261	Q08722
MHCSCLAEGIPANPG	ETV3L	1	Q6ZN32
DPTCLGMADPASVGN	GPRIN1	346	Q7Z2K8
PCPVNGMQVHSGETE	GTF2IRD2	91	Q86UP8
PCPVNGMQVHSGETE	GTF2IRD2B	91	Q6EKJ0
ESPQTMKLTLGHCPG	C4orf54	206	D6RIA3
MLEAPGPSDGCELSN	DUSP12	1	Q9UNI6
SVPLDTAGHPEPCLM	SLC22A13	71	Q9Y226
RENLLDPGMAACHGP	SACS	1506	Q9NZJ4
IPQHCSSELDGKAPM	SLC39A14	286	Q15043
KTHLCDVEIPGQGPM	NIT1	161	Q86X76
LIPGLAHDCMASPLA	AUNIP	106	Q9H7T9
ELSLCHVADAGSPGM	KIF1A	1326	Q12756
TATMLCAAGGNPDPE	PTPRF	151	P10586
PVTGPHLVGCGDVME	PAFAH2	11	Q99487
HIPPMLRATGCSQLG	INCA1	61	Q0VD86
DLPGMIDLPGSHDNS	MED19	111	A0JLT2
DVHGSSILPGMLCAG	F12	536	P00748
VCQGPHSSEMPPAGL	RUSC2	621	Q8N2Y8
GKLHLAGPCCPSEMD	RTBDN	51	Q9BSG5
DLEPAEGHGRTPCVM	KCNJ18	111	B7U540
PHEIPQQLNGSDCGM	SENP2	536	Q9HC62
LHATTCDGEPQGMLP	USH2A	3011	O75445
QEEMPPRPCGGHASS	TATDN2	466	Q93075
PPSLLDQLQMGCDGA	PPARD	51	Q03181
MACIENVLGGHAPSP	PRR32	1	B1ATL7
CALMLLEHGTDPNIP	POTEI	221	P0CG38
PGLPANGKMHSTVDC	SCN3A	636	Q9NY46
GPCDHTVVKLQPGDM	SKIV2L	911	Q15477
EKDQSTCHMEPGPGT	STAG3L1	186	P0CL83
PDMQEFHSCKGERPG	STARD9	1361	Q9P2P6
PSMGHRANLACSPLG	PRR12	321	Q9ULL5
CPPGRTGLLCHLEDM	NOTCH4	381	Q99466
EMGDTGPCGPCTEIH	AARS2	211	Q5JTZ9
TPGNSSLMLHLCRGP	SLC23A3	136	Q6PIS1
PHDGTMDPAGTCTTL	SARDH	206	Q9UL12
QPEHYSPVCGSDGLM	SLCO4A1	511	Q96BD0
MGTPPGLQTDCEALL	SNAPC1	1	Q16533
MAECPTLGEAVTDHP	TCL1A	1	P56279
PGLGMEHCDTLNVSL	CNN1	231	P51911
PQDGRMGPHLTASFC	RNF212	186	Q495C1
AKSPLPGDETQHMGC	TOP3B	786	O95985
MGSCSPHSNIEPSPV	STIL	671	Q15468
AMDAELAVAPPGCSH	USP22	11	Q9UPT9
RMPLPGDSGCHNPLS	TEX13D	321	A0A0J9YY54
RCGPTHQGSEDPSML	TRMT61B	111	Q9BVS5
PTLMHIPDGQDPVSC	SRGAP3	661	O43295
AAREMLHSPLPCTGG	SARM1	541	Q6SZW1
TGEPIRDPQGHCMAT	SLC27A3	466	Q5K4L6
RDPQGHCMATSPGEP	SLC27A3	471	Q5K4L6
HCMATSPGEPGLLVA	SLC27A3	476	Q5K4L6
NCHISLTPNGDMPGS	TMEM94	876	Q12767
LPAGLCSTLHPPMEN	SOBP	271	A7XYQ1
AICFGPSLMSVPEGH	SRGAP2	641	O75044
PSLMSVPEGHDQVSC	SRGAP2	646	O75044
LMHECPDYITGGPNS	PRLR	71	P16471
ICTDEYMGGQHPTNP	TYR	246	P14679
VQGCGAHPAIRMAPS	NF1	451	P21359
DVGMAELCPGLLHPS	RNH1	241	P13489
PGMLEPLLCGNSSDA	SCN8A	316	Q9UQD0
TGDILAGCHPNPMKL	PON3	276	Q15166
MSAAPGLLHQELSCP	TRIM72	1	Q6ZMU5
HPTEPCLLTAMGGSV	WDR83	286	Q9BRX9
VILAMDHCGEPSPDS	UNC5A	516	Q6ZN44
LNSDCHMATALPLGP	TMEM253	56	P0C7T8
CMLDGEIPSQSRPDG	ZNF484	66	Q5JVG2
EMGHLSRSCPDNPKG	ZCCHC9	191	Q8N567
ICEVSPGPHLNMIVG	SMC5	66	Q8IY18
CALMLLEHGTDPNIP	POTEG	221	Q6S5H5
CALMLLEHGTDPNIP	POTEM	221	A6NI47
EDPGRHPSCGKNLGM	ZNF285	201	Q96NJ3
GCNNLGIIMDHSPEP	TSHZ1	726	Q6ZSZ6
QDPLRHSCSPMGDGD	USP36	931	Q9P275
SCASHGPMSLGELEL	KIAA0586	1381	Q9BVV6
AQAMLSSHGDLGPPD	TRERF1	416	Q96PN7
PVSTPCAMENGGCSH	LRP4	1001	O75096
PGCMSPDVKNSIHVG	LIMK1	206	P53667
MNGQPLTCVVSHPGL	NECTIN4	216	Q96NY8