Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 ATM CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

8.33e-083639012GO:0106310
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CCND3 MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 ATM CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

9.97e-084469013GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

CCND3 MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 ATM CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

2.82e-066009013GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

CCND3 MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 ATM CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.69e-057099013GO:0016773
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

CCND3 MOK CSNK1D CSNK1E OASL CHEK2 PRKCD ROCK1 ATM GMPPB CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.81e-059389015GO:0016772
GeneOntologyMolecularFunctionsingle-stranded DNA endodeoxyribonuclease activity

MRE11 RBBP8 RAD50

2.45e-0513903GO:0000014
GeneOntologyMolecularFunctionkinase activity

CCND3 MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 ATM CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

3.69e-057649013GO:0016301
GeneOntologyMolecularFunctiongroup III metabotropic glutamate receptor activity

GRM7 GRM8

1.20e-044902GO:0001642
GeneOntologyMolecularFunctionATP-dependent activity

DHX36 MRE11 MDN1 MYO1H ATAD2B RAD54L2 ABCC2 DHX29 KIF24 RAD50

4.41e-046149010GO:0140657
GeneOntologyMolecularFunctionprotein kinase binding

CCND3 PTPN11 KCNH1 CHEK2 DNM3 TNS2 PRKCD RAD54L2 GOLGA8O MAP4K2 GOLGA8N MAP3K2

5.37e-048739012GO:0019901
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

DHX36 MRE11 RBBP8 PCIF1 MARF1 RAD54L2 DHX29 CDKAL1 DNMT1 RAD50

6.46e-046459010GO:0140640
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM7 GRM8

7.09e-049902GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM7 GRM8

7.09e-049902GO:0001640
GeneOntologyMolecularFunctionhelicase activity

DHX36 MRE11 RAD54L2 DHX29 RAD50

7.45e-04158905GO:0004386
GeneOntologyMolecularFunctionDNA endonuclease activity

MRE11 RBBP8 RAD50

1.03e-0344903GO:0004520
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

DHX36 MRE11 RBBP8 RAD54L2 DNMT1 RAD50

1.20e-03262906GO:0140097
GeneOntologyMolecularFunctionkinase binding

CCND3 PTPN11 KCNH1 CHEK2 DNM3 TNS2 PRKCD RAD54L2 GOLGA8O MAP4K2 GOLGA8N MAP3K2

1.33e-039699012GO:0019900
GeneOntologyMolecularFunctionG-quadruplex DNA binding

DHX36 RAD50

1.76e-0314902GO:0051880
GeneOntologyMolecularFunctioninsulin receptor substrate binding

PTPN11 PRKCD

2.03e-0315902GO:0043560
GeneOntologyMolecularFunctiontranslation activator activity

CTIF DHX29

2.03e-0315902GO:0008494
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNQ5 KCNH1

2.61e-0317902GO:0099508
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

DHX36 MRE11 RAD54L2 RAD50

2.62e-03127904GO:0008094
GeneOntologyMolecularFunctionDNA helicase activity

DHX36 MRE11 RAD50

2.76e-0362903GO:0003678
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

RIOX2 HSPBAP1 OGFOD1

3.16e-0365903GO:0016706
GeneOntologyMolecularFunctionDNA nuclease activity

MRE11 RBBP8 RAD50

3.44e-0367903GO:0004536
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX36 MDN1 ATAD2B RAD54L2 ABCC2 DHX29 RAD50

3.78e-03441907GO:0016887
GeneOntologyMolecularFunctiontranscription corepressor activity

RIOX2 YEATS2 ZNF366 RBBP8 ZNF451

3.79e-03229905GO:0003714
GeneOntologyMolecularFunctiontranscription coregulator activity

RIOX2 YEATS2 TADA1 ZNF366 RBBP8 ZNF451 RAD54L2 JMY

3.85e-03562908GO:0003712
GeneOntologyMolecularFunctionimportin-alpha family protein binding

GOLGA8O GOLGA8N

3.99e-0321902GO:0061676
GeneOntologyMolecularFunctiontau-protein kinase activity

CSNK1D ROCK1

4.38e-0322902GO:0050321
GeneOntologyBiologicalProcessDNA double-strand break processing

MRE11 RBBP8 ATM RAD50

2.23e-0622894GO:0000729
GeneOntologyBiologicalProcessmitotic G2/M transition checkpoint

MRE11 TICRR RBBP8 ATM RAD50

5.56e-0659895GO:0044818
GeneOntologyBiologicalProcessDNA strand resection involved in replication fork processing

MRE11 RBBP8 RAD50

9.12e-0610893GO:0110025
GeneOntologyBiologicalProcessnegative regulation of G2/M transition of mitotic cell cycle

MRE11 TICRR RBBP8 ATM RAD50

1.82e-0575895GO:0010972
GeneOntologyBiologicalProcessnegative regulation of cell cycle G2/M phase transition

MRE11 TICRR RBBP8 ATM RAD50

2.07e-0577895GO:1902750
GeneOntologyBiologicalProcessorganelle assembly

SNF8 RPL10L SNX4 MDN1 CSNK1D KIAA0586 CHEK2 OGFOD1 CFAP74 ATM GOLGA8O DHX29 KIF24 PLK4 RPL10 GOLGA8N

2.59e-0511388916GO:0070925
GeneOntologyBiologicalProcessmembraneless organelle assembly

RPL10L MDN1 CSNK1D CHEK2 OGFOD1 GOLGA8O DHX29 PLK4 RPL10 GOLGA8N

3.82e-054758910GO:0140694
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

CCND3 SNF8 RASSF5 DHX36 MRE11 PTPN11 CSNK1D CSNK1E PCIF1 CHEK2 PRKCD CTIF GOLGA8O DHX29 MAP4K2 GOLGA8N WDR24 RAD50

4.26e-0514588918GO:0051247
GeneOntologyBiologicalProcesscell cycle checkpoint signaling

MRE11 TICRR PTPN11 RBBP8 CHEK2 ATM RAD50

4.30e-05217897GO:0000075
GeneOntologyBiologicalProcessG2/M transition of mitotic cell cycle

MRE11 TICRR RBBP8 CHEK2 ATM RAD50

5.09e-05152896GO:0000086
GeneOntologyBiologicalProcessregulation of protein modification process

CCND3 SNF8 RASSF5 YEATS2 MRE11 PTPN11 CSNK1D UCHL1 CHEK2 PRKCD ROCK1 ZZEF1 GOLGA8O ADAR MAP4K2 GOLGA8N WDR24 RAD50

5.56e-0514888918GO:0031399
GeneOntologyBiologicalProcessmitotic cell cycle checkpoint signaling

MRE11 TICRR RBBP8 CHEK2 ATM RAD50

7.51e-05163896GO:0007093
GeneOntologyBiologicalProcessmeiotic nuclear division

RPL10L MRE11 MARF1 ATM GOLGA8O GOLGA8N RAD50

8.11e-05240897GO:0140013
GeneOntologyBiologicalProcessnegative regulation of protein binding

CSNK1E PRKCD ROCK1 GOLGA8O GOLGA8N

9.61e-05106895GO:0032091
GeneOntologyBiologicalProcesscell cycle G2/M phase transition

MRE11 TICRR RBBP8 CHEK2 ATM RAD50

9.78e-05171896GO:0044839
GeneOntologyBiologicalProcessDNA repair

MRE11 TICRR TADA1 SLF2 RBBP8 CSNK1E CHEK2 MARF1 ATM JMY RAD50

1.07e-046488911GO:0006281
GeneOntologyBiologicalProcesstelomeric 3' overhang formation

MRE11 RAD50

1.10e-044892GO:0031860
GeneOntologyBiologicalProcessregulation of telomere maintenance

DHX36 MRE11 SLF2 ATM RAD50

1.25e-04112895GO:0032204
GeneOntologyBiologicalProcesscell cycle process

CCND3 RPL10L MRE11 TICRR PTPN11 SLC16A1 SLF2 RBBP8 CSNK1D CHEK2 MARF1 ROCK1 ATM GOLGA8O PLK4 GOLGA8N RAD50

1.26e-0414418917GO:0022402
GeneOntologyBiologicalProcesspositive regulation of chromosome organization

DHX36 MRE11 SLF2 ATM RAD50

1.30e-04113895GO:2001252
GeneOntologyBiologicalProcessmeiotic cell cycle

RPL10L MRE11 RBBP8 MARF1 ATM GOLGA8O GOLGA8N RAD50

1.36e-04350898GO:0051321
GeneOntologyBiologicalProcessregulation of G2/M transition of mitotic cell cycle

MRE11 TICRR RBBP8 ATM RAD50

1.47e-04116895GO:0010389
GeneOntologyBiologicalProcessmeiotic cell cycle process

RPL10L MRE11 MARF1 ATM GOLGA8O GOLGA8N RAD50

1.61e-04268897GO:1903046
GeneOntologyBiologicalProcessorganelle localization

SNF8 SNX4 MDN1 CSNK1D UCHL1 DNM3 ATM GOLGA8O CLUH MAP4K2 GOLGA8N

2.17e-047038911GO:0051640
GeneOntologyBiologicalProcessDNA damage response

MRE11 TICRR PTPN11 TADA1 SLF2 RBBP8 CSNK1E CHEK2 MARF1 PRKCD ATM JMY RAD50

2.32e-049598913GO:0006974
GeneOntologyBiologicalProcessribosomal large subunit assembly

RPL10L MDN1 RPL10

2.35e-0428893GO:0000027
GeneOntologyBiologicalProcessregulation of cell cycle G2/M phase transition

MRE11 TICRR RBBP8 ATM RAD50

2.59e-04131895GO:1902749
GeneOntologyBiologicalProcesspositive regulation of telomere maintenance

DHX36 MRE11 ATM RAD50

2.66e-0472894GO:0032206
GeneOntologyBiologicalProcessribosome assembly

RPL10L MDN1 DHX29 RPL10

2.96e-0474894GO:0042255
GeneOntologyBiologicalProcesshomologous recombination

MRE11 RBBP8 ATM RAD50

2.96e-0474894GO:0035825
GeneOntologyBiologicalProcessDNA damage checkpoint signaling

MRE11 TICRR PTPN11 CHEK2 ATM

3.08e-04136895GO:0000077
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle phase transition

MRE11 TICRR RBBP8 CHEK2 ATM RAD50

3.73e-04219896GO:1901991
GeneOntologyBiologicalProcessnegative regulation of cell cycle phase transition

MRE11 TICRR PTPN11 RBBP8 CHEK2 ATM RAD50

3.97e-04311897GO:1901988
GeneOntologyBiologicalProcessDNA integrity checkpoint signaling

MRE11 TICRR PTPN11 CHEK2 ATM

4.14e-04145895GO:0031570
GeneOntologyBiologicalProcessdouble-strand break repair

MRE11 SLF2 RBBP8 CHEK2 MARF1 ATM RAD50

5.07e-04324897GO:0006302
GeneOntologyBiologicalProcessregulation of mitotic recombination

MRE11 RAD50

5.07e-048892GO:0000019
GeneOntologyBiologicalProcesstelomere maintenance via telomere lengthening

DHX36 MRE11 ATM RAD50

6.24e-0490894GO:0010833
GeneOntologyBiologicalProcessnegative regulation of telomere capping

ATM RAD50

6.50e-049892GO:1904354
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

GRM7 GRM8

6.50e-049892GO:0007196
GeneOntologyBiologicalProcessR-loop processing

MRE11 RAD50

6.50e-049892GO:0062176
GeneOntologyBiologicalProcessmitotic DNA damage checkpoint signaling

MRE11 TICRR CHEK2 ATM

6.50e-0491894GO:0044773
GeneOntologyBiologicalProcessprotein-RNA complex assembly

RPL10L MDN1 ATM ADAR DHX29 RPL10

6.60e-04244896GO:0022618
GeneOntologyBiologicalProcesspositive regulation of protein modification process

CCND3 RASSF5 MRE11 PTPN11 CSNK1D CHEK2 PRKCD GOLGA8O MAP4K2 GOLGA8N WDR24 RAD50

6.81e-049378912GO:0031401
GeneOntologyBiologicalProcessmitotic G2 DNA damage checkpoint signaling

MRE11 TICRR ATM

6.84e-0440893GO:0007095
GeneOntologyBiologicalProcessDNA metabolic process

DHX36 MRE11 TICRR TADA1 SLF2 RBBP8 CSNK1E CHEK2 MARF1 PRKCD ATM JMY RAD50

7.23e-0410818913GO:0006259
GeneOntologyBiologicalProcesstelomere capping

MRE11 ATM RAD50

7.35e-0441893GO:0016233
GeneOntologyBiologicalProcessregulation of phosphorylation

CCND3 SNF8 MRE11 PTPN11 CSNK1D UCHL1 CHEK2 PRKCD ROCK1 ZZEF1 ADAR MAP4K2 WDR24 RAD50

7.40e-0412268914GO:0042325
GeneOntologyBiologicalProcessmitotic DNA integrity checkpoint signaling

MRE11 TICRR CHEK2 ATM

7.64e-0495894GO:0044774
GeneOntologyBiologicalProcesstelomere maintenance

DHX36 MRE11 SLF2 ATM RAD50

8.08e-04168895GO:0000723
GeneOntologyBiologicalProcessprotein-RNA complex organization

RPL10L MDN1 ATM ADAR DHX29 RPL10

8.14e-04254896GO:0071826
GeneOntologyBiologicalProcessnegative regulation of binding

CSNK1E PRKCD ROCK1 GOLGA8O GOLGA8N

8.52e-04170895GO:0051100
GeneOntologyBiologicalProcesspositive regulation of catabolic process

SNF8 DHX36 SNX4 CSNK1D CSNK1E UCHL1 PRKCD ROCK1 ATM WDR24

8.73e-047018910GO:0009896
GeneOntologyBiologicalProcessregulation of catabolic process

SNF8 DHX36 CRTC3 SNX4 CSNK1D CSNK1E UCHL1 CHEK2 PRKCD ROCK1 ATM GOLGA8O GOLGA8N WDR24

9.07e-0412528914GO:0009894
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

PTPN11 SLF2 CSNK1D CSNK1E ZNF451 CHEK2 OGFOD1 PRKCD ROCK1 ATM ZZEF1 CDC42BPB

9.72e-049768912GO:0018193
GeneOntologyBiologicalProcessnegative regulation of cell cycle process

MRE11 TICRR PTPN11 RBBP8 CHEK2 ATM RAD50

9.72e-04362897GO:0010948
GeneOntologyBiologicalProcessoxaloacetate metabolic process

CS MDH1B

9.87e-0411892GO:0006107
GeneOntologyBiologicalProcessregulation of protein phosphorylation

CCND3 SNF8 MRE11 PTPN11 CSNK1D UCHL1 CHEK2 PRKCD ZZEF1 ADAR MAP4K2 WDR24 RAD50

1.11e-0311338913GO:0001932
GeneOntologyBiologicalProcessmannose metabolic process

MAN2C1 GMPPB

1.18e-0312892GO:0006013
GeneOntologyBiologicalProcessregulation of autophagosome assembly

SNX4 CHEK2 ATM

1.31e-0350893GO:2000785
GeneOntologyBiologicalProcessdouble-strand break repair via homologous recombination

MRE11 SLF2 RBBP8 ATM RAD50

1.33e-03188895GO:0000724
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

CCND3 MRE11 PTPN11 CSNK1D UCHL1 CHEK2 PRKCD ROCK1 MAP4K2 WDR24 RAD50

1.39e-038798911GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

CCND3 MRE11 PTPN11 CSNK1D UCHL1 CHEK2 PRKCD ROCK1 MAP4K2 WDR24 RAD50

1.39e-038798911GO:0010562
GeneOntologyBiologicalProcessnegative regulation of mitotic cell cycle

MRE11 TICRR RBBP8 CHEK2 ATM RAD50

1.39e-03282896GO:0045930
GeneOntologyCellularComponentBRCA1-C complex

MRE11 RBBP8 RAD50

1.48e-066893GO:0070533
GeneOntologyCellularComponentsite of double-strand break

MRE11 SLF2 RBBP8 ATM RAD50

7.17e-05101895GO:0035861
GeneOntologyCellularComponentchromosome, telomeric region

DHX36 MRE11 SLF2 CHEK2 ATM RAD50

1.07e-04176896GO:0000781
GeneOntologyCellularComponentMre11 complex

MRE11 RAD50

1.78e-045892GO:0030870
GeneOntologyCellularComponentsite of DNA damage

MRE11 SLF2 RBBP8 ATM RAD50

3.00e-04137895GO:0090734
GeneOntologyCellularComponentGolgi cis cisterna

GOLGA8O GOLGA8Q GOLGA8N

3.71e-0433893GO:0000137
DomainZF_DAG_PE_1

RASSF5 STAC2 TNS2 PRKCD ROCK1 CDC42BPB

5.18e-0764876PS00479
DomainZF_DAG_PE_2

RASSF5 STAC2 TNS2 PRKCD ROCK1 CDC42BPB

5.18e-0764876PS50081
DomainC1

RASSF5 STAC2 TNS2 PRKCD ROCK1 CDC42BPB

5.68e-0765876SM00109
DomainPE/DAG-bd

RASSF5 STAC2 TNS2 PRKCD ROCK1 CDC42BPB

6.23e-0766876IPR002219
DomainPROTEIN_KINASE_ST

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

9.36e-073628711PS00108
DomainKinase-like_dom

MOK CSNK1D CSNK1E CHEK2 DNM3 PRKCD ROCK1 ATM CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.29e-065428713IPR011009
DomainPkinase

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.54e-063818711PF00069
DomainSer/Thr_kinase_AS

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 CDC42BPB MAP4K2 MAP3K2 MAP3K19

6.22e-063578710IPR008271
DomainS_TKc

MOK CSNK1D CHEK2 PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

6.53e-063598710SM00220
DomainPROTEIN_KINASE_ATP

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

9.14e-064598711PS00107
DomainProtein_kinase_ATP_BS

MOK CSNK1D CSNK1E PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.05e-053798710IPR017441
DomainProt_kinase_dom

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.65e-054898711IPR000719
DomainPROTEIN_KINASE_DOM

MOK CSNK1D CSNK1E CHEK2 PRKCD ROCK1 CDC42BPB PLK4 MAP4K2 MAP3K2 MAP3K19

1.78e-054938711PS50011
DomainRibosomal_L10e_CS

RPL10L RPL10

2.14e-052872IPR018255
DomainRibosomal_L10e

RPL10L RPL10

2.14e-052872IPR001197
DomainRIBOSOMAL_L10E

RPL10L RPL10

2.14e-052872PS01257
DomainRibosomal_L10e/L16

RPL10L RPL10

6.42e-053872IPR016180
Domain-

RPL10L RPL10

6.42e-0538723.90.1170.10
DomainRibosomal_L16

RPL10L RPL10

6.42e-053872PF00252
DomainC1_1

RASSF5 STAC2 PRKCD CDC42BPB

1.44e-0457874PF00130
DomainCupin_4

RIOX2 HSPBAP1

4.44e-047872PF08007
Domain-

PLEKHG1 DNM3 SNTG1 MCF2 TNS2 ROCK1 EPB41L4A CDC42BPB

4.75e-043918782.30.29.30
DomainGPCR_3_mtglu_rcpt

GRM7 GRM8

5.90e-048872IPR000162
DomainPkinase_C

PRKCD ROCK1 CDC42BPB

6.76e-0437873IPR017892
DomainPH_dom-like

PLEKHG1 DNM3 SNTG1 MCF2 TNS2 ROCK1 EPB41L4A CDC42BPB

8.32e-04426878IPR011993
DomainMIF4G

UPF2 CTIF

9.42e-0410872SM00543
DomainMIF4G

UPF2 CTIF

9.42e-0410872PF02854
DomainMIF4G-like_typ-3

UPF2 CTIF

9.42e-0410872IPR003890
DomainPkinase_C

PRKCD ROCK1 CDC42BPB

9.83e-0442873PF00433
DomainNCD3G

GRM7 GRM8

1.62e-0313872PF07562
DomainGPCR_3_9-Cys_dom

GRM7 GRM8

1.62e-0313872IPR011500
DomainGPCR_3_CS

GRM7 GRM8

1.88e-0314872IPR017979
DomainCNH

CDC42BPB MAP4K2

1.88e-0314872SM00036
DomainPH

PLEKHG1 DNM3 SNTG1 MCF2 ROCK1 CDC42BPB

1.90e-03278876SM00233
DomainPH_DOMAIN

PLEKHG1 DNM3 SNTG1 MCF2 ROCK1 CDC42BPB

1.93e-03279876PS50003
DomainPH_domain

PLEKHG1 DNM3 SNTG1 MCF2 ROCK1 CDC42BPB

1.97e-03280876IPR001849
DomainCNH

CDC42BPB MAP4K2

2.17e-0315872PF00780
DomainMIF4-like

UPF2 CTIF

2.17e-0315872IPR016021
DomainCNH

CDC42BPB MAP4K2

2.17e-0315872PS50219
DomainCNH_dom

CDC42BPB MAP4K2

2.17e-0315872IPR001180
Domain-

UPF2 CTIF

2.17e-03158721.25.40.180
DomainAGC-kinase_C

PRKCD ROCK1 CDC42BPB

2.26e-0356873IPR000961
DomainAGC_KINASE_CTER

PRKCD ROCK1 CDC42BPB

2.26e-0356873PS51285
DomainS_TK_X

PRKCD ROCK1 CDC42BPB

2.26e-0356873SM00133
DomainDUF1605

DHX36 DHX29

2.79e-0317872IPR011709
DomainOB_NTP_bind

DHX36 DHX29

2.79e-0317872PF07717
DomainGOLGA2L5

GOLGA8O GOLGA8N

3.13e-0318872PF15070
DomainGolgin_A

GOLGA8O GOLGA8N

3.13e-0318872IPR024858
DomainHA2

DHX36 DHX29

3.13e-0318872SM00847
DomainHA2

DHX36 DHX29

3.13e-0318872PF04408
DomainHelicase-assoc_dom

DHX36 DHX29

3.13e-0318872IPR007502
DomainGPCR_3

GRM7 GRM8

4.25e-0321872IPR000337
DomainDAG/PE-bd

PRKCD CDC42BPB

4.25e-0321872IPR020454
DomainPH

PLEKHG1 DNM3 MCF2 ROCK1 CDC42BPB

4.34e-03229875PF00169
PathwayBIOCARTA_ATM_PATHWAY

MRE11 RBBP8 CHEK2 ATM RAD50

3.30e-0820685M10628
PathwayPID_ATM_PATHWAY

MRE11 RBBP8 CHEK2 ATM RAD50

5.62e-0734685M84
PathwayREACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS

MRE11 ATM RAD50

2.12e-066683M27585
PathwayREACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS

MRE11 ATM RAD50

2.12e-066683MM15295
PathwayWP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE

MRE11 RBBP8 CHEK2 ATM RAD50

2.95e-0647685M39518
PathwayBIOCARTA_ATRBRCA_PATHWAY

MRE11 CHEK2 ATM RAD50

3.39e-0622684M9703
PathwayWP_DDX1_AS_A_REGULATORY_COMPONENT_OF_THE_DROSHA_MICROPROCESSOR

MRE11 ATM RAD50

3.71e-067683M39689
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

MRE11 RBBP8 ATM RAD50

6.83e-0626684MM15297
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA

MRE11 RBBP8 ATM RAD50

7.99e-0627684M27586
PathwayPID_P53_REGULATION_PATHWAY

CSNK1D CSNK1E CHEK2 PRKCD ATM

9.20e-0659685M261
PathwayPID_BARD1_PATHWAY

MRE11 RBBP8 ATM RAD50

1.07e-0529684M258
PathwayWP_SMC1SMC3_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME

MRE11 ATM RAD50

1.72e-0511683M42562
PathwayWP_DNA_DAMAGE_RESPONSE

CCND3 MRE11 CHEK2 ATM RAD50

1.99e-0569685M39339
PathwayREACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ

MRE11 RBBP8 RAD50

2.29e-0512683M27569
PathwayREACTOME_HDR_THROUGH_MMEJ_ALT_NHEJ

MRE11 RBBP8 RAD50

2.29e-0512683MM15282
PathwayWP_HOMOLOGOUS_RECOMBINATION

MRE11 ATM RAD50

2.29e-0512683MM15951
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES

MRE11 RBBP8 ATM RAD50

2.32e-0535684MM15293
PathwayREACTOME_G2_M_DNA_DAMAGE_CHECKPOINT

MRE11 RBBP8 CHEK2 ATM RAD50

2.45e-0572685MM15381
PathwayREACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA

MRE11 RBBP8 ATM RAD50

2.60e-0536684MM15281
PathwayREACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES

MRE11 RBBP8 ATM RAD50

2.90e-0537684M27583
PathwayREACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA

MRE11 RBBP8 ATM RAD50

2.90e-0537684M27568
PathwayWP_HOMOLOGOUS_RECOMBINATION

MRE11 ATM RAD50

2.97e-0513683M39712
PathwayKEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING

MRE11 ATM RAD50

2.97e-0513683M47832
PathwayWP_ATM_SIGNALING

MRE11 CHEK2 ATM RAD50

3.97e-0540684M39433
PathwayWP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR

MRE11 RBBP8 CHEK2 ATM RAD50

4.34e-0581685M39490
PathwayREACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE

MRE11 RBBP8 ATM RAD50

5.30e-0543684M27588
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION

MRE11 RBBP8 CHEK2 ATM RAD50

8.00e-0592685MM15338
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION

MRE11 RBBP8 CHEK2 ATM RAD50

8.00e-0592685M27636
PathwayWP_INTEGRATED_CANCER_PATHWAY

MRE11 CHEK2 ATM RAD50

8.21e-0548684M39628
PathwayKEGG_MEDICUS_REFERENCE_DNA_END_RESECTION_AND_RPA_LOADING

MRE11 RBBP8 RAD50

8.32e-0518683M47838
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION

CHEK2 ATM JMY

8.32e-0518683MM15342
PathwayREACTOME_G2_M_DNA_DAMAGE_CHECKPOINT

MRE11 RBBP8 CHEK2 ATM RAD50

8.86e-0594685M1080
PathwayBIOCARTA_ATM_PATHWAY

MRE11 CHEK2 RAD50

9.84e-0519683MM1351
PathwayBIOCARTA_ATRBRCA_PATHWAY

MRE11 CHEK2 RAD50

9.84e-0519683MM1478
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_METHYLATION

CHEK2 ATM JMY

9.84e-0519683M27639
PathwayREACTOME_DISEASES_OF_DNA_REPAIR

MRE11 RBBP8 ATM RAD50

1.04e-0451684M29854
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY

MRE11 RBBP8 CHEK2 ATM JMY RAD50

1.07e-04157686MM15226
PathwayWP_MIRNA_REGULATION_OF_DNA_DAMAGE_RESPONSE

CCND3 MRE11 CHEK2 ATM RAD50

1.08e-0498685M39524
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY

MRE11 RBBP8 CHEK2 ATM JMY RAD50

1.19e-04160686M27498
PathwayREACTOME_CELL_CYCLE

CCND3 MRE11 RBBP8 CSNK1D CSNK1E CHEK2 ATM GOLGA8O PLK4 GOLGA8N RAD50

1.33e-046036811MM14635
PathwayWP_DNA_IRDOUBLE_STRAND_BREAKS_AND_CELLULAR_RESPONSE_VIA_ATM

MRE11 CHEK2 ATM RAD50

1.40e-0455684M39598
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE

MRE11 CHEK2 ATM RAD50

1.61e-0457684MM15298
PathwayREACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR

MRE11 RBBP8 ATM RAD50

1.85e-0459684MM15283
PathwayWP_15Q11Q13_COPY_NUMBER_VARIATION

SLF2 GOLGA8O CDC42BPB GOLGA8Q

1.85e-0459684M48104
PathwayWP_ANDROGEN_RECEPTOR_NETWORK_IN_PROSTATE_CANCER

MRE11 PTPN11 CHEK2 ATM RAD50

1.86e-04110685M48043
PathwayREACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR

MRE11 RBBP8 ATM RAD50

3.57e-0470684M27570
PathwayREACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS

MRE11 RBBP8 ATM RAD50

4.65e-0475684MM15299
PathwayWP_NONHOMOLOGOUS_END_JOINING

MRE11 RAD50

4.74e-047682MM15989
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

CCND3 PTPN11

4.74e-047682MM15524
PathwayWP_JOUBERT_SYNDROME

MRE11 KIAA0586 ATM RAD50

4.89e-0476684M39835
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE

MRE11 CHEK2 ATM RAD50

5.40e-0478684M27589
PathwayREACTOME_G2_M_CHECKPOINTS

MRE11 RBBP8 CHEK2 ATM RAD50

6.25e-04143685MM15383
PathwayBIOCARTA_PLK3_PATHWAY

CHEK2 ATM

6.30e-048682M22021
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

MRE11 RBBP8 CHEK2 ATM RAD50

6.87e-04146685MM15292
PathwayREACTOME_MEIOTIC_RECOMBINATION

MRE11 RBBP8 ATM RAD50

8.52e-0488684M1011
PathwayKEGG_MEDICUS_REFERENCE_CDC25_CELL_CYCLE_G2_M

CHEK2 ATM

1.01e-0310682M47572
PathwayREACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE

CSNK1D CSNK1E KIF24 PLK4

1.18e-0396684MM15207
PathwayREACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS

MRE11 RBBP8 ATM RAD50

1.22e-0397684M27590
PathwayREACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE

CSNK1D CSNK1E KIF24 PLK4

1.22e-0397684M27478
PathwayREACTOME_G2_M_CHECKPOINTS

MRE11 RBBP8 CHEK2 ATM RAD50

1.25e-03167685M19381
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

MRE11 RBBP8 CHEK2 ATM RAD50

1.36e-03170685M27582
PathwayREACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ

MRE11 ATM RAD50

1.50e-0347683MM15296
PathwayPID_FANCONI_PATHWAY

MRE11 ATM RAD50

1.50e-0347683M1
PathwayPID_HEDGEHOG_GLI_PATHWAY

CSNK1D CSNK1E PRKCD

1.59e-0348683M219
PathwayKEGG_NON_HOMOLOGOUS_END_JOINING

MRE11 RAD50

1.73e-0313682M7857
PathwayKEGG_CIRCADIAN_RHYTHM_MAMMAL

CSNK1D CSNK1E

1.73e-0313682M18009
PathwayREACTOME_DNA_DAMAGE_TELOMERE_STRESS_INDUCED_SENESCENCE

MRE11 ATM RAD50

2.23e-0354683MM14904
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM7 GRM8

2.31e-0315682M39442
PathwayKEGG_MEDICUS_REFERENCE_P300_P21_CELL_CYCLE_G1_S

CCND3 ATM

2.31e-0315682M47524
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM7 GRM8

2.31e-0315682MM15845
PathwayREACTOME_HOMOLOGY_DIRECTED_REPAIR

MRE11 RBBP8 ATM RAD50

2.36e-03116684MM15294
PathwayKEGG_OTHER_GLYCAN_DEGRADATION

MAN2C1 AGA

2.63e-0316682M17844
PathwayREACTOME_MEIOSIS

MRE11 RBBP8 ATM RAD50

2.67e-03120684M529
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

CCND3 PTPN11

2.98e-0317682M27788
PathwayWP_WNT_SIGNALING

CCND3 CSNK1E PRKCD

3.16e-0361683MM15893
PathwayBIOCARTA_MAL_PATHWAY

ROCK1 MAP4K2

3.34e-0318682MM1482
PathwayPID_BETA_CATENIN_DEG_PATHWAY

CSNK1D CSNK1E

3.34e-0318682M31
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53

MRE11 RBBP8 CHEK2 ATM JMY RAD50

3.41e-03304686MM14960
PathwayREACTOME_PROTEIN_HYDROXYLATION

RIOX2 OGFOD1

3.72e-0319682MM17069
PathwayBIOCARTA_MAL_PATHWAY

ROCK1 MAP4K2

3.72e-0319682M10547
PathwayWP_P53_SIGNALING

CCND3 CHEK2 ATM

3.79e-0365683MM15852
Pubmed

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

MRE11 CHEK2 ATM RAD50

2.29e-10592416905549
Pubmed

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

MRE11 CHEK2 ATM RAD50

6.85e-10692416357220
Pubmed

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

MRE11 CHEK2 ATM RAD50

6.85e-10692420086180
Pubmed

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

MRE11 CHEK2 ATM RAD50

6.85e-10692415790808
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RIOX2 DHX36 MRE11 PTPN11 CS MDN1 SLC16A1 CSNK1E UCHL1 KIAA0586 SRP68 PRKCD ATM TTC3 ADAR DHX29 CLUH RPL10 DNMT1 RAD50

7.79e-101425922030948266
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

RIOX2 DHX36 TICRR MDN1 AKAP17A UPF2 RBM27 PHF3 CSNK1E SRP68 ADAR DHX29 RPL10 DNMT1 WDR24

1.46e-09759921535915203
Pubmed

Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks.

MRE11 RBBP8 ATM RAD50

1.59e-09792430952868
Pubmed

53BP1 promotes ATM activity through direct interactions with the MRN complex.

MRE11 CHEK2 ATM RAD50

3.18e-09892420010693
Pubmed

Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.

MRE11 CHEK2 ATM RAD50

3.18e-09892416540636
Pubmed

Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.

MRE11 RBBP8 ATM RAD50

1.49e-081192419584272
Pubmed

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.

MRE11 RBBP8 RAD50

1.79e-08392319633668
Pubmed

Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.

MRE11 ATM RAD50

1.79e-08392326280532
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RPL10L YEATS2 SLF2 RBBP8 UCHL1 KIAA1217 ZNF451 ROCK1 ZDBF2 GIT2 RAD54L2 RAD50

5.18e-08588921238580884
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

RIOX2 MRE11 UPF2 RBM27 PHF3 MARF1 SRP68 GIT2 TTC3 ADAR DHX29 CDC42BPB CLUH

6.12e-08724921336232890
Pubmed

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.

MRE11 ATM RAD50

7.15e-08492318596698
Pubmed

CDK targets Sae2 to control DNA-end resection and homologous recombination.

MRE11 RBBP8 RAD50

7.15e-08492318716619
Pubmed

The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.

CSNK1D CSNK1E DNMT1

7.15e-08492320192920
Pubmed

NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.

MRE11 ATM RAD50

7.15e-08492328369484
Pubmed

Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection.

MRE11 RBBP8 RAD50

7.15e-08492327889449
Pubmed

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.

MRE11 ATM RAD50

7.15e-08492317429352
Pubmed

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.

MRE11 ATM RAD50

7.15e-08492328855246
Pubmed

Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.

MRE11 ATM RAD50

7.15e-08492323912341
Pubmed

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

MRE11 ATM RAD50

7.15e-08492315234984
Pubmed

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.

MRE11 RBBP8 RAD50

7.15e-08492327814491
Pubmed

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner.

MRE11 ATM RAD50

7.15e-08492318256278
Pubmed

ATM activation in the presence of oxidative stress.

MRE11 ATM RAD50

7.15e-08492321150274
Pubmed

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

MRE11 ATM RAD50

7.15e-08492315965469
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

YEATS2 MRE11 MDN1 SLF2 CSNK1E ZNF451 RAD54L2 RAD50

1.43e-0722292837071664
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

MRE11 STAC2 RBBP8 CSNK1D TNS2 DNMT1 RAD50

1.49e-0714992725184681
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX36 MRE11 MDN1 PHF3 ATAD2B OASL SRP68 ATM CLUH RPL10 DNMT1 RAD50

1.60e-07653921222586326
Pubmed

DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

MRE11 ATM RAD50

1.78e-07592324220101
Pubmed

A role for DEAD box 1 at DNA double-strand breaks.

MRE11 ATM RAD50

1.78e-07592318710941
Pubmed

ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.

MRE11 ATM RAD50

1.78e-07592318829552
Pubmed

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

MRE11 ATM RAD50

1.78e-07592323525106
Pubmed

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.

MRE11 ATM RAD50

1.78e-07592329844578
Pubmed

Analysis of variants in DNA damage signalling genes in bladder cancer.

MRE11 ATM RAD50

1.78e-07592318638378
Pubmed

ATM activation is impaired in human cells defective in RecQL4 helicase activity.

MRE11 ATM RAD50

1.78e-07592330594395
Pubmed

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.

MRE11 ATM RAD50

1.78e-07592324534091
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

RIOX2 MRPS30 MRE11 C3P1 SNX4 PTPN11 MDN1 PHF3 ZNF451 ROCK1 CLUH RPL10

2.84e-07689921236543142
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

MRE11 TADA1 MDN1 SLF2 RBBP8 PHF3 ZNF451 ATM RAD54L2 RAD50

3.54e-07453921029656893
Pubmed

DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.

MRE11 ATM RAD50

3.56e-07692318381424
Pubmed

CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.

MRE11 RBBP8 RAD50

3.56e-07692330657944
Pubmed

Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

MRE11 RBBP8 RAD50

3.56e-07692318171670
Pubmed

MDC1 is required for the intra-S-phase DNA damage checkpoint.

MRE11 ATM RAD50

3.56e-07692312607003
Pubmed

The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.

MRE11 RBBP8 RAD50

3.56e-07692329709199
Pubmed

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

CHEK2 ATM RAD50

3.56e-07692315064416
Pubmed

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair.

MRE11 ATM RAD50

3.56e-07692325823024
Pubmed

Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.

MRE11 ATM RAD50

3.56e-07692330733337
Pubmed

NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1.

MRE11 ATM RAD50

3.56e-07692318763866
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PLEKHG1 CRTC3 MDN1 KCNQ5 SLC16A1 SLF2 CSNK1D PHF3 CSNK1E KIAA1217 PLK4 DNMT1 MAP3K2

4.42e-07861921336931259
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RIOX2 MRE11 TICRR MDN1 ANK1 HSPBAP1 ATAD2B PCIF1 SRP68 ATM ZZEF1 RPL10

5.71e-07736921229676528
Pubmed

The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.

MRE11 CHEK2 ATM

6.22e-07792325768017
Pubmed

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

MRE11 ATM RAD50

6.22e-07792319221393
Pubmed

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

MRE11 ATM RAD50

6.22e-07792322464731
Pubmed

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control.

MRE11 ATM RAD50

6.22e-07792317694070
Pubmed

RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.

MRE11 ATM RAD50

6.22e-07792336563124
Pubmed

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2.

MRE11 RBBP8 RAD50

6.22e-07792322231403
Pubmed

Inhibition of hsp90 compromises the DNA damage response to radiation.

MRE11 ATM RAD50

6.22e-07792316982765
Pubmed

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

MRE11 CHEK2 ATM

6.22e-07792318614044
Pubmed

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.

MRE11 ATM RAD50

6.22e-07792314519663
Pubmed

Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.

CCND3 MRE11 CHEK2 ATM DNMT1 RAD50

7.17e-0711792619124506
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

YEATS2 MRE11 MDN1 RBBP8 PHF3 CSNK1E PRKCD ATM DHX29 CLUH DNMT1 RAD50

9.67e-07774921215302935
Pubmed

Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

MRE11 ATM RAD50

9.94e-07892315456891
Pubmed

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

MRE11 RBBP8 RAD50

9.94e-07892326455393
Pubmed

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection.

MRE11 RBBP8 RAD50

9.94e-07892331501894
Pubmed

Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.

MRE11 ATM RAD50

9.94e-07892319638463
Pubmed

Role of the translocation partner in protection against AID-dependent chromosomal translocations.

CHEK2 PRKCD ATM

9.94e-07892319966290
Pubmed

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.

MRE11 ATM RAD50

9.94e-07892315916964
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DHX36 MRE11 UPF2 SLC16A1 RBM27 CSNK1D PHF3 CSNK1E KIAA1217 OASL SRP68 ADAR RPL10 DNMT1 RAD50

1.04e-061257921536526897
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RASSF5 YEATS2 MRE11 PTPN11 RBM27 UCHL1 KIAA1217 SRP68 ADAR DHX29 RPL10 DNMT1 RAD50

1.10e-06934921333916271
Pubmed

Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.

MRE11 RBBP8 ATM RAD50

1.37e-063192419690177
Pubmed

Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.

MRE11 CHEK2 ATM RAD50

1.77e-063392419714462
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

DHX36 YEATS2 MRE11 CS MDN1 ANK1 AKAP17A UPF2 SLC16A1 RBM27 SRP68 ADAR CDKAL1 RPL10 DNMT1

1.87e-061318921530463901
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

YEATS2 MRE11 PTPN11 SLC16A1 RBM27 PHF3 SRP68 ADAR DNMT1 RAD50

2.00e-06549921038280479
Pubmed

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways.

MRE11 ATM RAD50

2.12e-061092329523790
Pubmed

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

MRE11 ATM RAD50

2.91e-061192315758953
Pubmed

MDC1 is a mediator of the mammalian DNA damage checkpoint.

MRE11 ATM RAD50

2.91e-061192312607005
Pubmed

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

MRE11 ATM RAD50

2.91e-061192311877377
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

MRE11 MDN1 PHF3 SRP68 RAD54L2 RPL10 DNMT1 RAD50

2.94e-0633292832786267
Pubmed

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

MRE11 ATM RAD50

3.87e-061292330017584
Pubmed

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

MRE11 RBBP8 RAD50

3.87e-061292316391231
Pubmed

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).

MRE11 CHEK2 ATM

3.87e-061292315149599
Pubmed

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

MRE11 ATM RAD50

3.87e-061292310783165
Pubmed

Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.

MRE11 RBBP8 CHEK2 ATM RAD50

4.04e-068992518950845
Pubmed

BRCA1 tumor suppressor network: focusing on its tail.

MRE11 RBBP8 RAD50

5.03e-061392322369660
Pubmed

The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.

CCND3 RBBP8 RAD50

6.38e-061492316600870
Pubmed

RAD50 regulates mitotic progression independent of DNA repair functions.

MRE11 RAD50

6.92e-06292231908056
Pubmed

Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells.

CHEK2 ATM

6.92e-06292233607997
Pubmed

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.

MRE11 ATM

6.92e-06292233571423
Pubmed

Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.

CHEK2 ATM

6.92e-06292212857758
Pubmed

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

CHEK2 ATM

6.92e-06292216794575
Pubmed

Somatic inactivation of ATM in hematopoietic cells predisposes mice to cyclin D3 dependent T cell acute lymphoblastic leukemia.

CCND3 ATM

6.92e-06292225659036
Pubmed

Decreased expression of MRE11 and RAD50 in testes from humans with spermatogenic failure.

MRE11 RAD50

6.92e-06292231983050
Pubmed

Hepatitis B virus X protein activates the ATM-Chk2 pathway and delays cell cycle progression.

CHEK2 ATM

6.92e-06292225872745
Pubmed

CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.

CSNK1D CSNK1E

6.92e-06292224424021
Pubmed

Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

GRM7 GRM8

6.92e-06292223220400
Pubmed

Clinicopathologic Profile of Breast Cancer in Germline ATM and CHEK2 Mutation Carriers.

CHEK2 ATM

6.92e-06292233919281
Pubmed

Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.

CSNK1D CSNK1E

6.92e-0629229632646
Pubmed

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.

CHEK2 ATM

6.92e-06292220599567
Pubmed

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.

MRE11 ATM

6.92e-06292220647759
InteractionPER3 interactions

CSNK1D CSNK1E CHEK2 ATM CLUH

7.05e-0824925int:PER3
InteractionWWTR1 interactions

YEATS2 MRE11 PTPN11 RBM27 PHF3 UCHL1 SRP68 ADAR DNMT1 MAP3K2 RAD50

3.50e-064229211int:WWTR1
InteractionHECTD1 interactions

RIOX2 DHX36 TICRR MDN1 AKAP17A UPF2 RBM27 PHF3 CSNK1E DNM3 SRP68 ADAR DHX29 RPL10 DNMT1 WDR24

8.84e-069849216int:HECTD1
InteractionCACNG2 interactions

CSNK1D CSNK1E CHEK2 ABCC2

1.50e-0533924int:CACNG2
InteractionBIRC3 interactions

RIOX2 DHX36 MRE11 CS MDN1 SLC16A1 CSNK1E UCHL1 KIAA0586 SRP68 PRKCD TTC3 ADAR DHX29 CLUH RPL10 DNMT1 RAD50

2.86e-0513349218int:BIRC3
InteractionPYHIN1 interactions

DHX36 MRE11 MDN1 SLC16A1 PHF3 UCHL1 RPL10 DNMT1 RAD50

3.78e-05358929int:PYHIN1
InteractionDCLRE1C interactions

MRE11 CHEK2 ATM RAD50

4.38e-0543924int:DCLRE1C
InteractionSLX4 interactions

YEATS2 MRE11 PTPN11 MDN1 SLF2 CSNK1E ZNF451 RAD54L2 ADAR RPL10 RAD50

5.88e-055729211int:SLX4
InteractionCCT8L2 interactions

YEATS2 MRE11 SNX4 MDN1 ZFHX4 RAD50

8.34e-05157926int:CCT8L2
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

MRE11 RBBP8 RAD50

3.29e-0755931336
GeneFamilyBRCA1 C complex|MRN complex

MRE11 RAD50

3.13e-0535921344
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM7 GRM8

2.89e-048592281
GeneFamilyDEAH-box helicases

DHX36 DHX29

1.22e-0316592500
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K2 MAP3K19

2.76e-0324592654
CoexpressionKAUFFMANN_DNA_REPAIR_GENES

PMS2P2 MRE11 RBBP8 CSNK1D CSNK1E CHEK2 ATM RAD50

1.54e-06230928M11563
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

MRPS30 DHX36 MRE11 PTPN11 SLC16A1 RBBP8 CSNK1D OGFOD1 TTC3 PLK4 DNMT1 RAD50

8.32e-067219212M10237
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

CCND3 RIOX2 PTPN11 MDN1 AKAP17A UPF2 SLF2 CSNK1D AGA ATAD2B PRKCD ROCK1 ATM TTC3 PLK4

2.06e-0512159215M41122
CoexpressionPUJANA_ATM_PCC_NETWORK

PMS2P2 MRE11 SNX4 AKAP17A UPF2 RBBP8 KCNH1 PHF3 CHEK2 PRKCD ROCK1 GIT2 ATM ADAR PLK4 DNMT1

2.57e-0513949216M9585
CoexpressionPUJANA_XPRSS_INT_NETWORK

MRE11 RBBP8 CHEK2 ATM PLK4 DNMT1

2.87e-05168926M18811
CoexpressionPUJANA_BREAST_CANCER_LIT_INT_NETWORK

MRE11 RBBP8 CHEK2 ATM RAD50

2.90e-05101925M15356
CoexpressionPUJANA_BRCA_CENTERED_NETWORK

MRE11 RBBP8 CHEK2 ATM DNMT1

6.11e-05118925M15305
CoexpressionGSE13411_PLASMA_CELL_VS_MEMORY_BCELL_DN

CCND3 PMS2P2 MDN1 MARF1 GIT2 RPL10

6.96e-05197926M3255
CoexpressionGSE17974_1.5H_VS_72H_IL4_AND_ANTI_IL12_ACT_CD4_TCELL_UP

CRTC3 CSNK1D HSPBAP1 EPB41L4A JMY MAP3K2

7.16e-05198926M4247
CoexpressionGSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_DN

CCND3 AKAP17A PHF3 HSPBAP1 MARF1 DHX29

7.36e-05199926M4310
CoexpressionGSE22589_HIV_VS_HIV_AND_SIV_INFECTED_DC_DN

RIOX2 STAC2 CRTC3 SLF2 DNMT1 WDR24

7.57e-05200926M7801
CoexpressionGSE17721_CTRL_VS_CPG_2H_BMDC_UP

DHX36 TADA1 SLF2 CSNK1D PRKCD ATM

7.57e-05200926M3759
CoexpressionEPPERT_PROGENITOR

MRE11 ANK1 KCNQ5 CHEK2 PLK4

1.28e-04138925M19232
CoexpressionPUJANA_BRCA2_PCC_NETWORK

CCND3 PMS2P2 MRE11 RBBP8 ATAD2B CHEK2 PLK4 DNMT1

1.29e-04426928M9516
CoexpressionNAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN

RBM27 CSNK1D PHF3 CSNK1E ZNF451 PCIF1 MARF1 ZDBF2 JMY MAP3K2

1.38e-046809210M41089
CoexpressionJAIN_NFKB_SIGNALING

MRE11 SNX4 CLUH RAD50

1.43e-0475924M17646
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

MOK DHX36 TICRR MDN1 UPF2 SLC16A1 RBM27 RBBP8 PHF3 ATAD2B KIAA0586 CFAP74 ROCK1 ZDBF2 ATM KIF24 PLK4 CDKAL1 DNMT1 RAD50

1.27e-0712578720facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

MOK DHX36 TICRR MDN1 KCNQ5 UPF2 SLC16A1 RBM27 RBBP8 PHF3 ATAD2B KIAA0586 CFAP74 ROCK1 ZDBF2 ATM KIF24 PLK4 CDKAL1 DNMT1 RAD50

3.08e-0714598721facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlasdev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

RIOX2 MRE11 TICRR SLC16A1 RBM27 ZNF451 CHEK2 EPB41L4A RAD50

1.13e-06258879gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k2_1000
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

RIOX2 MRE11 MDN1 RBM27 ZNF451 ATM EPB41L4A PLK4 RAD50

1.45e-06266879gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000

RIOX2 RPL10L MRE11 TICRR MDN1 SLC16A1 RBM27 UCHL1 ZNF451 KIAA0586 CHEK2 ATM EPB41L4A RAD50

4.30e-067998714gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

RBM27 RBBP8 PHF3 ROCK1 ZDBF2 ATM EPB41L4A TTC3 KIF24 PLK4 DNMT1

1.10e-055328711Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

SNX4 PTPN11 UPF2 SLF2 CSNK1D ATAD2B KIAA0586 CHEK2 CFAP74 DHX29 RAD50

1.90e-055648711Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

RIOX2 MDN1 RBM27 UCHL1 ZNF451 KIAA0586 RAD50

6.33e-05243877gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k4_1000
CoexpressionAtlasdev gonad_e11.5_M_PrimGermCell_Oct_top-relative-expression-ranked_1000

RIOX2 RPL10L MRE11 TICRR MDN1 SLC16A1 RBM27 ZNF451 CHEK2 ATM EPB41L4A RAD50

7.95e-057818712gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_1000
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000

RIOX2 MRE11 TICRR MDN1 RBM27 UCHL1 ZNF451 CHEK2 ATM EPB41L4A PLK4 RAD50

9.41e-057958712gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000

RIOX2 MDN1 RBM27 HSPBAP1 UCHL1 ZNF451 KIAA0586 CHEK2 ATM EPB41L4A KIF24 RAD50

1.12e-048108712gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

RIOX2 MRE11 TICRR MDN1 RBM27 RBBP8 ZNF451 CHEK2 ATM EPB41L4A KIF24 RAD50

1.26e-048208712gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

RIOX2 MRE11 TICRR MDN1 RBM27 UCHL1 ZNF451 KIAA0586 CHEK2 ATM EPB41L4A RAD50

1.29e-048228712gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

MDN1 UPF2 MARF1 DNM3 CTIF JMY

1.72e-06177916e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RASSF5 KCNH1 SNTG1 ZDBF2 TTC3 GRM8

2.67e-061919165d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RASSF5 KCNH1 SNTG1 ZDBF2 TTC3 GRM8

2.67e-0619191673dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK1 SLF2 CSNK1D ZDBF2 TTC3 RPL10

2.84e-061939161aa3ab528605dc7b2fec46e759c9d1ee93d59b11
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

RBM27 PHF3 ROCK1 TTC3 JMY RAD50

3.39e-0619991618a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF3 ATAD2B OASL ROCK1 ATM ADAR

3.48e-0620091612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellControl-B_intermediate-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MRE11 MDN1 SLF2 MARF1 RAD50

2.38e-05167915948504367ecf58144d9dd74d2ec531358fc4b309
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Deuterosomal|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MOK MDH1B CFAP74 KIF24 PLK4

2.67e-0517191552aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOK MDH1B CFAP74 KIF24 MAP3K19

3.24e-051789156178706db4a855d72abc156537604d575624df56
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOK MDH1B CFAP74 KIF24 MAP3K19

3.24e-05178915f02076ece0fa899e620971c887ad4da7f48684ed
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR CHEK2 GRM8 KIF24 PLK4

3.32e-0517991588d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

PLEKHG1 ZNF366 KIAA1217 EPB41L4A GRM8

3.50e-05181915c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Deuterosomal|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MYO1H CFAP74 KIF24 PLK4 MAP3K19

3.60e-05182915000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRPS30 CSNK1E KIAA0586 TTC3 CDC42BPB

3.99e-0518691537860daeecd6d412bd3797f30496a56da667fbd1
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRPS30 CSNK1E KIAA0586 TTC3 CDC42BPB

3.99e-0518691560830822d3de3147816693404fd03392e04c2b8e
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRPS30 CSNK1E KIAA0586 TTC3 CDC42BPB

3.99e-05186915baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

TICRR KIAA0586 CHEK2 KIF24 PLK4

4.64e-05192915026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCellsevere-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PLEKHG1 SLC16A1 DNM3 ZDBF2 GRM8

4.87e-051949152fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MOK MDH1B CFAP74 GRM7 MAP3K19

4.87e-051949154a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MRE11 TICRR KIF24 PLK4 DNMT1

5.12e-05196915df366d76ea55f49e349d622effa57c1535df8400
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

SNF8 DHX36 ROCK1 TTC3 RAD50

5.12e-051969157bced0cc2112697593c478fa291b8ed3941fb811
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

PLEKHG1 ZNF366 KIAA1217 EPB41L4A GRM8

5.12e-051969154ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

DHX36 CSNK1D PHF3 OASL ADAR

5.24e-051979155c33454b10023decd2f5ccda9229b6512659711e
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MYO1H CFAP74 KIF24 PLK4 MAP3K19

5.24e-051979156e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

PLEKHG1 ZNF366 KIAA1217 DNM3 EPB41L4A

5.24e-05197915f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

PTPN11 RBM27 ROCK1 TTC3 RAD50

5.50e-0519991519674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

PTPN11 PHF3 ROCK1 TTC3 RAD50

5.50e-05199915fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

PTPN11 RBM27 ROCK1 TTC3 RAD50

5.50e-05199915d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 ZNF366 KIAA1217 EPB41L4A GRM8

5.63e-05200915105c67e4f5eff036013d655c8e8ac577d32dae2e
DrugDiloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A

RPL10L ZFHX4 CSNK1E KIAA0586 DNM3 CTIF GRM7 MAP4K2

1.25e-061979183399_DN
DrugVerdict

PTPN11 ZNF451 ADAR DNMT1

5.25e-0629914CID000050896
Drugwortmannin

CCND3 RIOX2 KCNH1 CHEK2 PRKCD ATM ABCC2 RAD50

1.18e-05267918ctd:C009687
DrugMelatonin [73-31-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A

RPL10L ZFHX4 PHF3 UCHL1 CTIF GRM7 PLK4

1.48e-051989175393_UP
Drugmethyl methanesulfonate

MRE11 RBBP8 CSNK1D CSNK1E CHEK2 PRKCD ATM DNMT1 RAD50

1.53e-05364919CID000004156
Drugethyl acetate

MOK PRSS3 KCNH1 ATM GRM7 GRM8

1.86e-05137916CID000008857
Diseasesyndromic X-linked intellectual disability Najm type (implicated_via_orthology)

RPL10L CSNK1D CSNK1E RPL10

2.45e-097874DOID:0060807 (implicated_via_orthology)
DiseaseBreast Cancer, Familial

MRE11 CHEK2 ATM RAD50

1.82e-0630874C0346153
DiseaseNijmegen Breakage Syndrome-Like Disorder

MRE11 RAD50

8.59e-062872C2751318
DiseaseHereditary Breast and Ovarian Cancer Syndrome

MRE11 CHEK2 RAD50

8.80e-0614873C0677776
DiseaseT-cell acute lymphoblastic leukemia (implicated_via_orthology)

RPL10L RPL10

2.57e-053872DOID:5603 (implicated_via_orthology)
Diseaseunipolar depression, neuroticism measurement

ZNF366 PHF3 KIAA1217

4.79e-0524873EFO_0003761, EFO_0007660
Diseaseautistic disorder (implicated_via_orthology)

RPL10L RPL10

5.14e-054872DOID:12849 (implicated_via_orthology)
DiseaseMalignant neoplasm of breast

MRE11 MAN2C1 ANK1 ZNF366 KCNH1 CSNK1D CHEK2 CTIF ATM TTC3 ADAR DNMT1

7.30e-0510748712C0006142
Diseasesporadic Creutzfeld Jacob disease

GAL3ST1 GRM8

8.54e-055872EFO_1000656
Diseaseserum metabolite measurement

CCND3 ACADL AGA OASL PCIF1 PRKCD ABCC2 GRM7 MAP4K2 CDKAL1 DNMT1

1.04e-049458711EFO_0005653
Diseasemean arterial pressure

PLEKHG1 YEATS2 PTPN11 KIAA1217 SNTG1 TNS2 GRM7 DNMT1

1.15e-04499878EFO_0006340
Diseasespondyloepiphyseal dysplasia congenita (implicated_via_orthology)

RPL10L RPL10

1.28e-046872DOID:14789 (implicated_via_orthology)
Diseaseinsulin sensitivity measurement, insulin response measurement

ANK1 CDKAL1

2.38e-048872EFO_0004471, EFO_0008473
Diseasefemale breast cancer (is_implicated_in)

CHEK2 ATM

2.38e-048872DOID:0050671 (is_implicated_in)
Diseaseinsulin response measurement

ANK1 CDKAL1

3.05e-049872EFO_0008473
DiseaseNeuroblastoma

RASSF5 PTPN11 CHEK2

3.65e-0447873C0027819
Diseaseobsolete_red blood cell distribution width

CCND3 MOK PLEKHG1 STAC2 ANK1 RBM27 ZNF366 KIAA1217 ATAD2B PCIF1 CHEK2 CLUH

5.83e-0413478712EFO_0005192
Diseasemean reticulocyte volume

CCND3 PTPN11 ANK1 KIAA1217 ATAD2B PCIF1 CHEK2 ATM CDKAL1

5.83e-04799879EFO_0010701
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ5 DNM3

6.56e-0413872DOID:0112202 (implicated_via_orthology)
DiseaseMammary Carcinoma, Human

MAN2C1 ZNF366 KCNH1 CHEK2 ATM ADAR DNMT1

9.30e-04525877C4704874
DiseaseMammary Neoplasms, Human

MAN2C1 ZNF366 KCNH1 CHEK2 ATM ADAR DNMT1

9.30e-04525877C1257931
DiseaseMammary Neoplasms

MAN2C1 ZNF366 KCNH1 CHEK2 ATM ADAR DNMT1

9.50e-04527877C1458155
DiseaseBreast Carcinoma

MAN2C1 ZNF366 KCNH1 CHEK2 ATM ADAR DNMT1

1.07e-03538877C0678222
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

CHEK2 ATM

1.42e-0319872C1333991
Diseaseleukemia (implicated_via_orthology)

PTPN11 ATM

1.42e-0319872DOID:1240 (implicated_via_orthology)
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

CHEK2 ATM

1.42e-0319872C2936783
DiseaseAdenocarcinoma of prostate

CHEK2 ATM

1.58e-0320872C0007112
Diseasefeeling miserable measurement

MYO1H ATAD2B CLUH

1.67e-0379873EFO_0009598
DiseaseSeckel syndrome

RBBP8 PLK4

1.91e-0322872C0265202
DiseaseAttention Deficit Disorder

GRM7 GRM8

1.91e-0322872C0041671
DiseaseMinimal Brain Dysfunction

GRM7 GRM8

1.91e-0322872C1321905
DiseasePrimary microcephaly

RBBP8 PLK4

1.91e-0322872C0431350
DiseaseAttention deficit hyperactivity disorder

GRM7 GRM8

2.27e-0324872C1263846
Diseaseneutrophil count

CCND3 RASSF5 STAC2 TADA1 ZNF366 RBBP8 CHEK2 DNM3 ADAR CDKAL1 DNMT1

2.44e-0313828711EFO_0004833
Diseasemyeloproliferative disorder

CHEK2 ATM

2.47e-0325872EFO_0004251
Diseasebreast cancer (implicated_via_orthology)

MRE11 RAD50

2.47e-0325872DOID:1612 (implicated_via_orthology)
Diseasebirth weight, parental genotype effect measurement

CRTC3 ZFHX4 MAP4K2 DNMT1

2.54e-03192874EFO_0004344, EFO_0005939
DiseaseNeurodevelopmental Disorders

PTPN11 KCNH1 CDC42BPB

2.65e-0393873C1535926
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

CHEK2 ATM

2.67e-0326872C0009405
DiseaseHereditary non-polyposis colorectal cancer syndrome

CHEK2 ATM

2.88e-0327872C1112155
DiseaseMalignant tumor of breast

CHEK2 ATM

2.88e-0327872cv:C0006142
DiseaseBreast neoplasm

CHEK2 ATM

2.88e-0327872cv:C1458155
DiseaseFamilial cancer of breast

CHEK2 ATM

2.88e-0327872cv:C0346153

Protein segments in the cluster

PeptideGeneStartEntry
PRDRQALVKKHAQTF

CCND3

171

P30281
QPEKLDFTQFHRKVR

CTIF

116

O43310
DFTQFHRKVRHTPKQ

CTIF

121

O43310
QNFPHIEVVRKKEER

RBBP8

791

Q99708
IRVNKFYRPENTHKS

DNMT1

1016

P26358
RKSVRKFFQEEVIPH

ACADL

61

P28330
LVPVKKAAQQRSFHF

ANK1

1301

P16157
QDKVHPNKAEFIRAK

GIT2

96

Q14161
NKPEEVQPRFFKVHI

RAD54L2

361

Q9Y4B4
KKHFRIFREVGPKNS

CHEK2

141

O96017
LKERQQLPVFKHRDS

DHX29

566

Q7Z478
DPNRNVEHRERSKFK

RBM27

191

Q9P2N5
VVDNPQKFALFKRIH

RASSF5

311

Q8WWW0
GPFSERQIKNFHKLV

RAD50

386

Q92878
IHFKKELREPQFRDA

RAD50

1086

Q92878
QFHQVKFGAPRRKET

MAP4K2

331

Q12851
RHPKQEKRSVFQTIN

SLC16A1

236

P53985
INHRSLEQKKTFPNR

OGFOD1

516

Q8N543
EREFRKQFPLHEKDF

MDN1

3571

Q9NU22
VRPHVFDEREKHKFV

JMY

16

Q8N9B5
QKERFNIDMPHRFKV

PRKCD

221

Q05655
VPAHQKKRENTLFDI

ATAD2B

301

Q9ULI0
REFLFNLPDQKARKH

ATAD2B

566

Q9ULI0
KHFEKRRNPAANLIQ

KCNQ5

361

Q9NR82
IHRFVEKPQVFVSNK

GMPPB

156

Q9Y5P6
KINRIFHERFPFEIV

DNM3

361

Q9UQ16
SKNFIHRDVKPDNFL

CSNK1D

121

P48730
HEKLRQLAKPQSVFE

GOLGA8Q

361

H3BV12
VKFEHRGEKRILQFP

MAP3K2

46

Q9Y2U5
FRQLEVSQPRKHLFV

KIF24

341

Q5T7B8
LNRKVFKEHPAFRLA

KCNH1

571

O95259
PVIRAFEHQQRFLKH

ABCC2

1171

Q92887
QHPYFQEQRKTEKRA

MOK

281

Q9UQ07
KNRYKNILPFDHTRV

PTPN11

276

Q06124
EIQRTKPFHRKFNEI

CDC42BPB

1356

Q9Y5S2
IIFHPEQNVQKRKRS

GRM8

841

O00222
FSELQRNFVKHRPTK

OASL

191

Q15646
ECQPRRNIVFLKTHK

GAL3ST1

71

Q99999
DLKRFPQFRKAQRHA

HSPBAP1

226

Q96EW2
PDHVVFKDLRITQQK

ATM

1566

Q13315
AKLFFRRRHQQKDPG

C2CD2

631

Q9Y426
QSRFKRHQLILPAFE

PCIF1

601

Q9H4Z3
HEPRFKFQVVINGRE

ADAR

531

P55265
RQAKVRVEFPHKETL

C3P1

96

Q6ZMU1
DSKPQDRHFVRKDVV

CDKAL1

21

Q5VV42
NPRKFSEKIALHTQR

CRTC3

11

Q6UUV7
RYVPEQKEHRSQFKR

DHX36

406

Q9H2U1
IPKEQARIKTFRQQH

CS

41

O75390
QKNLPDFRIHKITQR

MDH1B

26

Q5I0G3
KQFSKDVVDLLRHQP

MARF1

1261

Q9Y4F3
EAHKFLKVEFPARVR

MAN2C1

806

Q9NTJ4
FRNLADKHVRPIQFV

MCF2

421

P10911
CQKVISRIQKHFPEF

AGA

286

P20933
HPELNVQKRKRSFKA

GRM7

851

Q14831
HEKLRQLAKPQSVFE

GOLGA8O

361

A6NCC3
RITKVHFKETQFELR

EPB41L4A

246

Q9HCS5
AQNRDKLFKVSVPHV

CFAP74

1151

Q9C0B2
REDAPHFLKEQQRKS

MAP3K19

176

Q56UN5
GDFRFHVRKKDQINI

UPF2

646

Q9HAU5
EHVIEALRRAKFKFP

RPL10L

146

Q96L21
IVHFLLNRPKEEKSQ

MRPS30

421

Q9NP92
FRVKNPDKRFTDLKH

SNX4

211

O95219
KLSSVRQKFDHRFQP

TADA1

101

Q96BN2
EHVIEALRRAKFKFP

RPL10

146

P27635
NQEPFKVRLHLAKDI

SNTG1

21

Q9NSN8
KQLFSTLPVRHKEFQ

PMS2P2

21

O95744
QHKEAKRFEIARSQP

KIAA1217

1616

Q5T5P2
PERRKSLFIHENNEK

SLF2

171

Q8IX21
NPKDIIHFFRHREQK

MRE11

391

P49959
LKNRVKPFSENEARH

PLK4

101

O00444
LKQEANTEPRKRFHL

SRP68

141

Q9UHB9
ASKHKQEIRKNPEFR

SNF8

51

Q96H20
KVRAAEFKIDFPTRH

AKAP17A

111

Q02040
NFAVLQKKRVQRHPF

CLUH

296

O75153
ELENQFKKTQRPAHI

ZNF451

986

Q9Y4E5
FPRIFDLITHQKKQC

ZFHX4

2276

Q86UP3
QRHFQKPVRIFLKGS

TICRR

331

Q7Z2Z1
KPVRLHSFQEHVFKR

STAC2

106

Q6ZMT1
HARELPKKRNFQLTF

ZDBF2

2136

Q9HCK1
PKKRNFQLTFLNHDV

ZDBF2

2141

Q9HCK1
LNFVEKERDFRKINH

TTC3

386

P53804
ESQQNFHRPVKVRKK

PHF3

536

Q92576
KDFDQKRATIQFHQP

RIOX2

126

Q8IUF8
KRATIQFHQPQRFKD

RIOX2

131

Q8IUF8
RNGVEEIKRHLFFKN

ROCK1

326

Q13464
NEQFINAAKIIRHPK

PRSS3

141

P35030
FDLSQKRRAKVPVFQ

ZNF366

591

Q8N895
HEEIRPVDFKQRNKA

ZZEF1

2011

O43149
KFFRERQETLKHSLP

PLEKHG1

226

Q9ULL1
RPSRNKQDQLFTEHK

WDR24

106

Q96S15
KRHDLTRLNPKVQDF

TNS2

181

Q63HR2
IPRKHSQKQIEEHFR

KIAA0586

581

Q9BVV6
PVRVQVHFKDSQNKR

YEATS2

286

Q9ULM3
LLFPLTAQHENFRKK

UCHL1

51

P09936
HEKLRQLAKPQSVFE

GOLGA8N

361

F8WBI6
SKNFIHRDVKPDNFL

CSNK1E

121

P49674
RKEPSKFDDFLIRHQ

MYO1H

601

Q8N1T3