Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE1 SPDYE11 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

4.35e-1427387GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE1 SPDYE11 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

5.79e-1428387GO:0099602
GeneOntologyMolecularFunctionprotein kinase binding

SPDYE1 SPDYE8 SPDYE21 SPDYE11 SPDYE17 SPDYE5 SPDYE18 SPDYE10 SPDYE12 SPDYE15 SPDYE2B SPDYE6 SPDYE14 SPDYE16 SPDYE2

2.18e-118733815GO:0019901
GeneOntologyMolecularFunctionkinase binding

SPDYE1 SPDYE8 SPDYE21 SPDYE11 SPDYE17 SPDYE5 SPDYE18 SPDYE10 SPDYE12 SPDYE15 SPDYE2B SPDYE6 SPDYE14 SPDYE16 SPDYE2

9.48e-119693815GO:0019900
GeneOntologyMolecularFunctionsignaling receptor regulator activity

SPDYE1 SPDYE11 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.41e-04616387GO:0030545
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.14e-1325286GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.30e-1228286GO:1904031
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.01e-0996286GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.86e-09100286GO:1904029
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.97e-07193286GO:0071902
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.29e-06350286GO:0045860
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

7.15e-06358286GO:0071900
GeneOntologyBiologicalProcesspositive regulation of kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.44e-05405286GO:0033674
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.48e-05407286GO:0045787
GeneOntologyBiologicalProcessregulation of kinase activity

SPDYE1 SPDYE5 SPDYE2B RBL1 SPDYE6 SPDYE16 SPDYE2

2.81e-05686287GO:0043549
GeneOntologyBiologicalProcesspositive regulation of transferase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

4.21e-05490286GO:0051347
GeneOntologyBiologicalProcessembryonic process involved in female pregnancy

SP1 SP3

7.94e-0510282GO:0060136
GeneOntologyBiologicalProcessregulation of transferase activity

SPDYE1 SPDYE5 SPDYE2B RBL1 SPDYE6 SPDYE16 SPDYE2

8.06e-05810287GO:0051338
GeneOntologyBiologicalProcessregulation of protein kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.42e-04611286GO:0045859
GeneOntologyBiologicalProcessmyeloid progenitor cell differentiation

SP1 SP3

1.60e-0414282GO:0002318
GeneOntologyBiologicalProcessenucleate erythrocyte differentiation

SP1 SP3

2.11e-0416282GO:0043353
GeneOntologyBiologicalProcessfolic acid metabolic process

MTRR MTERF1

2.68e-0418282GO:0046655
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.56e-04724286GO:0001934
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

5.30e-04780286GO:0042327
GeneOntologyBiologicalProcesstrophectodermal cell differentiation

SP1 SP3

5.66e-0426282GO:0001829
GeneOntologyBiologicalProcessdefinitive hemopoiesis

SP1 SP3

6.11e-0427282GO:0060216
GeneOntologyBiologicalProcessembryonic camera-type eye morphogenesis

SP1 SP3

8.60e-0432282GO:0048596
GeneOntologyBiologicalProcessfolic acid-containing compound metabolic process

MTRR MTERF1

9.71e-0434282GO:0006760
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

9.91e-04879286GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

9.91e-04879286GO:0010562
GeneOntologyBiologicalProcessregulation of phosphorylation

SPDYE1 SPDYE5 SPDYE2B RBL1 SPDYE6 SPDYE16 SPDYE2

1.01e-031226287GO:0042325
GeneOntologyBiologicalProcessregulation of cell cycle

SPDYE1 SPDYE5 SPDYE2B RBL1 SPDYE6 SPDYE16 SPDYE2

1.17e-031256287GO:0051726
GeneOntologyBiologicalProcessembryonic eye morphogenesis

SP1 SP3

1.21e-0338282GO:0048048
GeneOntologyBiologicalProcesspteridine-containing compound metabolic process

MTRR MTERF1

1.34e-0340282GO:0042558
GeneOntologyBiologicalProcesspositive regulation of protein modification process

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.38e-03937286GO:0031401
GeneOntologyBiologicalProcessembryonic camera-type eye development

SP1 SP3

1.70e-0345282GO:0031076
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

2.21e-031028286GO:0043085
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

SPDYE1 SPDYE5 SPDYE2B RBL1 SPDYE6 SPDYE16 SPDYE2

2.38e-031421287GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

SPDYE1 SPDYE5 SPDYE2B RBL1 SPDYE6 SPDYE16 SPDYE2

2.40e-031423287GO:0051174
GeneOntologyBiologicalProcesspositive regulation of molecular function

SPDYE1 SPDYE5 SPDYE2B SPDYE6 CFTR SPDYE16 SPDYE2

2.47e-031430287GO:0044093
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

SPDYE1 SP1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

2.75e-031458287GO:0051247
GeneOntologyBiologicalProcessregulation of protein modification process

SPDYE1 SPDYE5 SPOPL SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.09e-031488287GO:0031399
DomainSpy1

SPDYE1 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

4.26e-1811307PF11357
DomainSpeedy

SPDYE1 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

4.26e-1811307IPR020984
DomainSp1_fam

SP1 SP3 SP4

4.45e-0710303IPR030450
DomainMATH

SPOP SPOPL

1.63e-0412302SM00061
DomainMATH

SPOP SPOPL

1.63e-0412302PF00917
DomainMATH/TRAF_dom

SPOP SPOPL

1.63e-0412302IPR002083
DomainMATH

SPOP SPOPL

1.63e-0412302PS50144
Domain-

SPOP SPOPL

2.24e-04143022.60.210.10
DomainTRAF-like

SPOP SPOPL

6.73e-0424302IPR008974
DomainBTB

SPOP SPOPL

1.87e-02131302PF00651
PathwayWP_ESTRADIOL_REGULATION_IN_PORTOSINUSOIDAL_VASCULAR_DISEASE

SP1 SP3

1.21e-055162M45554
PathwayBIOCARTA_TERC_PATHWAY

SP1 SP3

1.81e-056162MM1564
PathwayBIOCARTA_TERC_PATHWAY

SP1 SP3

1.81e-056162M22047
PathwayBIOCARTA_TERT_PATHWAY

SP1 SP3

2.53e-057162MM1541
PathwayBIOCARTA_TERT_PATHWAY

SP1 SP3

3.37e-058162M22015
PathwayPID_SMAD2_3NUCLEAR_PATHWAY

SP1 SP3 RBL1

1.01e-0482163M2
PathwayBIOCARTA_CALCINEURIN_PATHWAY

SP1 SP3

1.83e-0418162M3430
PathwayBIOCARTA_CALCINEURIN_PATHWAY

SP1 SP3

1.83e-0418162MM1385
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

SP1 MTERF1

2.04e-0419162M39544
PathwayWP_MITOCHONDRIAL_GENE_EXPRESSION

SP1 MTERF1

2.04e-0419162MM15973
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

SP1 RBL1

3.86e-0426162MM14878
PathwayREACTOME_SIGNALING_BY_HEDGEHOG

TUBB6 SPOP SPOPL

4.58e-04137163MM15182
PathwayREACTOME_SIGNALING_BY_HEDGEHOG

TUBB6 SPOP SPOPL

5.97e-04150163M27440
PathwayWP_ONECARBON_METABOLISM

MTRR MTERF1

6.63e-0434162MM15859
PathwayREACTOME_AGGREPHAGY

TUBB6 CFTR

7.44e-0436162MM15669
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

SP1 RBL1

7.44e-0436162M633
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

SP1 RBL1

9.65e-0441162MM14876
PathwayWP_HEDGEHOG_SIGNALING_WP4249

SPOP SPOPL

1.06e-0343162M39706
PathwayREACTOME_AGGREPHAGY

TUBB6 CFTR

1.11e-0344162M29830
PathwayWP_SELENIUM_METABOLISM_SELENOPROTEINS

SP1 SP3

1.16e-0345162MM15877
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

SP1 SP3

1.21e-0346162MM15949
PathwayWP_SELENIUM_METABOLISM_AND_SELENOPROTEINS

SP1 SP3

1.27e-0347162M48301
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

SP1 RBL1

1.49e-0351162M665
PathwayPID_MYC_REPRESS_PATHWAY

SP1 RBL1

2.27e-0363162M254
PathwayPID_TELOMERASE_PATHWAY

SP1 SP3

2.56e-0367162M105
PathwayWP_MECP2_AND_ASSOCIATED_RETT_SYNDROME

SP1 SP3

3.03e-0373162M39401
PathwayPID_E2F_PATHWAY

SP1 RBL1

3.03e-0373162M40
PathwayREACTOME_SELECTIVE_AUTOPHAGY

TUBB6 CFTR

3.03e-0373162MM15672
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

SP1 SP3

3.19e-0375162M39568
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

SP1 RBL1

3.36e-0377162MM14670
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE1 SPDYE17 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.77e-181338715611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE1 SPDYE17 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

2.00e-171738715574121
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

9.42e-17938636272447
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE17 SPDYE6 SPDYE2

1.20e-09338322763696
Pubmed

Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.

SP1 SP3 SP4

1.20e-09338323540600
Pubmed

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.

SP1 SP3 SP4

1.20e-09338326967243
Pubmed

Curcumin decreases specificity protein expression in bladder cancer cells.

SP1 SP3 SP4

1.20e-09338318593936
Pubmed

Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

SP1 SP3 SP4

1.20e-09338321919647
Pubmed

Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.

SP1 SP3 SP4

1.20e-09338311532028
Pubmed

Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.

SP1 SP3 SP4

1.20e-0933837559627
Pubmed

Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.

SP1 SP3 SP4

4.81e-09438315781457
Pubmed

Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.

SP1 SP3 SP4

4.81e-09438327889927
Pubmed

Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.

SP1 SP3 SP4

1.20e-08538312560508
Pubmed

Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.

SP1 SP3 SP4

1.20e-08538320538607
Pubmed

Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.

SP1 SP3 SP4

1.20e-08538310547281
Pubmed

Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.

SP1 SP3 SP4

2.40e-08638316201967
Pubmed

POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.

SP1 SP3 SP4

4.20e-08738312004059
Pubmed

The DNA sequence of human chromosome 7.

SPDYE21 SP4 SPDYE5 SPDYE2B MTERF1 SPDYE6 SPDYE16

4.52e-0744138712853948
Pubmed

Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure.

SP1 SP3

1.16e-06238210825178
Pubmed

HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.

SP1 SP3

1.16e-06238231299490
Pubmed

Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells.

SP1 SP3

1.16e-06238219437621
Pubmed

CDK activation by non-cyclin proteins.

SPDYE17 SPDYE6

1.16e-06238216488127
Pubmed

Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription.

SP1 RBL1

1.16e-0623827565695
Pubmed

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

SPOP SPOPL

1.16e-06238216740475
Pubmed

Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3.

SP1 SP3

1.16e-0623828845379
Pubmed

Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.

SP1 SP4

1.16e-06238225175639
Pubmed

Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.

SP1 SP3

1.16e-06238214766015
Pubmed

Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.

SP1 SP3

1.16e-06238225538045
Pubmed

Established and novel Cdk/cyclin complexes regulating the cell cycle and development.

SPDYE17 SPDYE6

1.16e-06238221630153
Pubmed

Evolutionary expansion of SPOP and associated TD/POZ gene family: impact of evolutionary route on gene expression pattern.

SPOP SPOPL

1.16e-06238220399258
Pubmed

Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3.

SP1 SP3

1.16e-06238221604172
Pubmed

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.

SP3 SP4

1.16e-0623821454515
Pubmed

Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.

SP1 SP3

1.16e-06238221248046
Pubmed

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

SP1 SP3

1.16e-06238231164147
Pubmed

Sp1 and Sp3 activate transcription of the human dopamine transporter gene.

SP1 SP3

1.16e-06238215816870
Pubmed

Sp family transcription factors regulate expression of rat D2 dopamine receptor gene.

SP1 SP3

1.16e-0623829628590
Pubmed

Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus.

SP1 SP3

1.16e-06238217681019
Pubmed

Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.

SP1 SP3

1.16e-06238237735515
Pubmed

The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells.

SP1 SP3

1.16e-06238214608051
Pubmed

Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis.

SP1 SP4

1.16e-06238223941741
Pubmed

Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.

SP1 SP3

1.16e-06238226807725
Pubmed

An Sp1/Sp3 binding polymorphism confers methylation protection.

SP1 SP3

1.16e-06238218725933
Pubmed

Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.

SP1 SP3

1.16e-06238215951564
Pubmed

Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.

SP1 SP3

1.16e-0623829329821
Pubmed

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.

SPOP SPOPL

1.16e-06238216651542
Pubmed

Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.

SP1 SP3

1.16e-06238222464952
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

SP1 SP3 SP4

2.72e-062538315820306
Pubmed

Sp1 and Sp3 Are important regulators of AP-2gamma gene transcription.

SP1 SP3

3.48e-06338212801994
Pubmed

Expression of the human melanocortin-4 receptor gene is controlled by several members of the Sp transcription factor family.

SP1 SP3

3.48e-06338215821099
Pubmed

Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3.

SP1 SP3

3.48e-06338217652716
Pubmed

Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37.

SP1 SP3

3.48e-06338212730302
Pubmed

Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts.

SP1 SP3

3.48e-06338218417714
Pubmed

Activation of the RNA-dependent protein kinase PKR promoter in the absence of interferon is dependent upon Sp proteins.

SP1 SP3

3.48e-06338216339759
Pubmed

Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells.

SP1 SP3

3.48e-06338212694199
Pubmed

Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene.

SP1 SP3

3.48e-06338226162987
Pubmed

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

SP1 SP3

3.48e-06338214701757
Pubmed

Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.

SP1 SP3

3.48e-06338215118068
Pubmed

Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene.

SP1 SP3

3.48e-06338216677608
Pubmed

Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3.

SP1 SP3

3.48e-06338215111490
Pubmed

Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors.

SP1 SP3

3.48e-06338217317039
Pubmed

Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W.

SP1 SP3

3.48e-06338220180024
Pubmed

In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.

SP1 SP3

3.48e-06338211850421
Pubmed

Transcription factors sp1 and sp3 regulate expression of human extracellular superoxide dismutase in lung fibroblasts.

SP1 SP3

3.48e-06338218314536
Pubmed

Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation.

SP1 SP3

3.48e-06338212855685
Pubmed

Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells.

SP1 SP3

3.48e-06338215297147
Pubmed

Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression.

SP1 SP3

3.48e-06338221554857
Pubmed

Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase.

SP1 SP3

3.48e-06338215451065
Pubmed

Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.

SP1 SP3

3.48e-06338218790003
Pubmed

Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.

SP1 SP3

3.48e-06338230561605
Pubmed

Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

SP1 SP3

3.48e-06338211274368
Pubmed

Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways.

SP1 SP3

3.48e-06338212378384
Pubmed

The t-PA -7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid.

SP1 SP3

3.48e-06338215466927
Pubmed

Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements.

SP1 SP3

3.48e-06338212509426
Pubmed

Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.

SP1 SP3

3.48e-06338236759621
Pubmed

Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells.

SP1 SP3

3.48e-06338216052479
Pubmed

Sp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells.

SP1 SP3

3.48e-06338216529657
Pubmed

Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.

SP1 SP3

3.48e-06338224315822
Pubmed

Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter.

SP1 SP3

3.48e-06338211237613
Pubmed

Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha.

SP1 SP3

3.48e-06338217540780
Pubmed

SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium.

SP1 SP3

3.48e-06338216807381
Pubmed

Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence.

SP1 SP3

3.48e-06338223028678
Pubmed

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.

SP1 SP3

3.48e-06338219306294
Pubmed

Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.

SP1 SP3

3.48e-06338215247906
Pubmed

Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.

SP1 SP3

3.48e-06338215482850
Pubmed

IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1.

SP1 SP3

3.48e-06338216760259
Pubmed

Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells.

SP1 SP3

3.48e-06338215777284
Pubmed

Involvement of Sp1/Sp3 in the activation of the GATA-1 erythroid promoter in K562 cells.

SP1 SP3

3.48e-06338218195733
Pubmed

Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.

SP1 SP3

3.48e-06338210816575
Pubmed

The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells.

SP1 SP3

3.48e-06338231863909
Pubmed

Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.

SP3 SP4

3.48e-06338215265862
Pubmed

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.

SP1 SP3

3.48e-06338220091743
Pubmed

Regulation of the varicella-zoster virus ORF3 promoter by cellular and viral factors.

SP1 SP3

3.48e-06338223523134
Pubmed

O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.

SP3 SP4

3.48e-06338226431879
Pubmed

Structural and functional characterization of the mouse tescalcin promoter.

SP1 SP3

3.48e-06338220540995
Pubmed

Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.

SP1 SP3

3.48e-06338222682030
Pubmed

The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells.

SP1 SP3

3.48e-06338217906119
Pubmed

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

SP1 SP3

3.48e-06338224850855
Pubmed

HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity.

SP1 SP3

3.48e-06338215706661
Pubmed

NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.

SP1 SP3

3.48e-06338216671893
Pubmed

Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.

SP1 SP3

3.48e-06338227060138
InteractionTNFSF10 interactions

SP1 SP3 CFTR

1.36e-0535273int:TNFSF10
InteractionSP4 interactions

SP1 SP3 SP4

3.13e-0546273int:SP4
InteractionNKX3-1 interactions

SP1 SP3 SP4

4.54e-0552273int:NKX3-1
InteractionDEAF1 interactions

SP1 SP3 RBL1

8.46e-0564273int:DEAF1
InteractionRBBP4 interactions

SP1 SP3 ZC3H18 SPOP RBL1 CFTR

9.15e-05573276int:RBBP4
InteractionVEGFA interactions

SP1 SP3 CFTR

9.28e-0566273int:VEGFA
InteractionSP1 interactions

SP1 SP3 SP4 ZC3H18 RBL1

1.10e-04365275int:SP1
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE8 SPDYE21 SPDYE9 SPDYE11 SPDYE17 SPDYE5 SPDYE18 SPDYE10 SPDYE13 SPDYE12 SPDYE15 SPDYE14 SPDYE16

8.26e-202714013chr7q11
Cytoband7q11.23

SPDYE8 SPDYE9 SPDYE5 SPDYE18 SPDYE10 SPDYE14

2.75e-10974067q11.23
Cytoband7q22.1

SPDYE2B SPDYE6 SPDYE2

1.34e-041134037q22.1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

SPDYE2B SPDYE6 SPDYE2

9.29e-04219403chr7q22
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE1 SPDYE8 SPDYE9 SPDYE5 SPDYE2B SPDYE6 SPDYE2

2.18e-1812247756
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP1 SP3 SP4

1.72e-079243755
GeneFamilyBasic leucine zipper proteins|BTB domain containing

SPOP SPOPL

1.35e-02134242861
CoexpressionBRUINS_UVC_RESPONSE_LATE

SPDYE1 TUBB6 SPOP SPDYE5 SULT4A1 SPDYE2B SPDYE6 TUSC3 SPDYE16 SPDYE2

1.35e-0611983310MM1062
ComputationalNeighborhood of TNFRSF25

SULT4A1 NUDT13

4.08e-0430112CAR_TNFRSF25
DrugSP 0

SP1 SP3 SP4

2.46e-0710303CID002742752
Drughyperoside

SP1 SP3 SP4

4.10e-0624303ctd:C021304
DrugADP-ribosylarginine

SP1 SP3 SP4

4.66e-0625303CID000126311
Drughomocysteic acid

SP1 SP3

5.03e-063302ctd:C007956
DrugS-Nitrosoglutathione

SP1 SP3 CFTR

1.20e-0534303ctd:D026422
Drugpoly(tetramethylene adipate

SP3 SP4

1.67e-055302CID000032794
Drugelemicin

SP3 RBL1

1.67e-055302CID000010248
Drug3-(2-carboxyindol-3-yl)propionic acid

SP1 SP3 SP4

2.46e-0543303CID000169313
Drug1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane

SP1 SP4

9.16e-0511302ctd:C492909
DiseaseMale sterility

MTRR CFTR

8.21e-0448262C0917731
DiseaseMale infertility

MTRR CFTR

8.21e-0448262C0021364
DiseaseSubfertility, Male

MTRR CFTR

8.21e-0448262C0848676
Diseasepancreatic cancer (is_implicated_in)

MTRR CFTR

4.37e-03112262DOID:1793 (is_implicated_in)
Diseasemean reticulocyte volume

SP1 SP3 SPDYE12 RBL1

4.96e-03799264EFO_0010701
DiseaseSchizophrenia

CACNA1F SP1 SP4 SULT4A1

7.05e-03883264C0036341

Protein segments in the cluster

PeptideGeneStartEntry
NALRRCFFWRFMFYG

CFTR

71

P13569
FFWRLCRTFGKIFTN

RELCH

861

Q9P260
HRGSFCRSWFNMLDL

CACNA1F

931

O60840
FGAMWLFFGCRHKDR

MTRR

571

Q9UBK8
MSLYCGIACRRKFFW

NUDT13

1

Q86X67
RWIFGKFFCRVSAMF

GPR63

146

Q9BZJ6
MGCSWRKTLSFFLVF

PTX4

1

Q96A99
GWMRMISFIRSFCKY

RGSL1

791

A5PLK6
PFICNWMFCGKRFTR

SP4

676

Q02446
FCWTLFVYTKGNFRM

RBL1

176

P28749
RFHFFCSMRCRAWVS

SPDYE10

226

P0DUX0
RFHFFCSMRCRAWVS

SPDYE11

226

P0DTA3
RFHFFCSMRCRAWVS

SPDYE8

226

P0DUD1
FMCTWSYCGKRFTRS

SP1

656

P08047
KRRFHFFCSMSCRAW

SPDYE2B

361

A6NHP3
CFMFSIWRFAWRKSI

TLCD5

206

Q6ZRR5
WRYSSAFCNKLFFSM

TUSC3

116

Q13454
FCRRFMNDKLGYGSW

SULT4A1

161

Q9BR01
SAMFRRKAFLHWFTG

TUBB6

386

Q9BUF5
ASRGWFMRFKERSHF

TIGD1

131

Q96MW7
RFHFFCSMRCRAWVS

SPDYE12

226

P0DUX1
RFHFFCSMRCRAWVS

SPDYE13

226

A0A494C0Z2
RFHFFCSMRCRAWVS

SPDYE14

226

P0DUD3
RFHFFCSMRCRAWVS

SPDYE15

226

P0DUD4
KLRFQFFCSMSGRAW

SPDYE16

271

A6NNV3
RFHFFCSMRCRAWVS

SPDYE17

226

P0DUD2
KLRFQFFCSMSGRAW

SPDYE18

311

P0DV79
KFSYMWTINNFSFCR

SPOPL

31

Q6IQ16
KLRFQFFCSMSGRAW

SPDYE21

361

A0A494C086
KFSYMWTINNFSFCR

SPOP

31

O43791
KRRFHFFCSMSCRAW

SPDYE2

361

Q495Y8
KRRFQFFCSMSGRAW

SPDYE5

361

A6NIY4
KRRFHFFCSMSCRAW

SPDYE6

361

P0CI01
FVCNWMYCGKRFTRS

SP3

651

Q02447
RRFHFFCSMSCRAWV

SPDYE1

296

Q8NFV5
NNFLFGSRCWMTRFS

MTERF1

31

Q99551
MKRCSFLWAYAAQLA

UBR7

186

Q8N806
RFQFFCSMSGRAWVS

nan

251

A6NJR5
RFHFFCSMRCRAWVS

SPDYE9

226

A0A494C191
FFMKGNCTWGMNCRF

ZC3H18

226

Q86VM9
ASFMSFGVKRRWFAL

TMEM101

66

Q96IK0