Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of mitochondrial DNA metabolic process

LIG3 ATG7

7.77e-062582GO:1901859
GeneOntologyBiologicalProcessnegative regulation of mitochondrial DNA replication

LIG3 ATG7

7.77e-062582GO:0090298
DomainRII_binding_1

AKAP3 AKAP13

9.10e-055572PF10522
DomainRII_binding_1

AKAP3 AKAP13

9.10e-055572IPR018459
DomainBRCT

LIG3 REV1

2.03e-0322572SM00292
Domain-

LIG3 REV1

2.22e-03235723.40.50.10190
DomainBRCT

LIG3 REV1

2.84e-0326572PS50172
DomainBRCT_dom

LIG3 REV1

3.29e-0328572IPR001357
DomainFHA

KIF1A STARD9

3.29e-0328572SM00240
DomainFHA

KIF1A STARD9

4.02e-0331572PF00498
DomainPH

KIF1A AKAP13 PLEKHO1 CIT

5.23e-03229574PF00169
DomainFHA_dom

KIF1A STARD9

5.39e-0336572IPR000253
Domain-

KIF1A STARD9

5.39e-03365722.60.200.20
DomainKinesin_motor_CS

KIF1A STARD9

6.95e-0341572IPR019821
DomainKINESIN_MOTOR_1

KIF1A STARD9

7.97e-0344572PS00411
Domain-

KIF1A STARD9

7.97e-03445723.40.850.10
DomainKinesin_motor_dom

KIF1A STARD9

7.97e-0344572IPR001752
DomainKinesin

KIF1A STARD9

7.97e-0344572PF00225
Pubmed

CFAP43 modulates ciliary beating in mouse and Xenopus.

COX4I1 AKAP3 CFAP43

2.45e-07858331884020
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

LIG3 HK1 HYOU1 KIF1A STARD9 COX4I1 RTN3 LRRC40 MSH2 TESK1 SNRPD3 YARS1

3.32e-061425581230948266
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

HK1 HYOU1 AP1B1 ATG7 PPFIA1 PPME1 ANKRD28 MSH2 POLD3 SNRPD3 YTHDF2 YARS1

4.11e-061455581222863883
Pubmed

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.

POLD3 REV1

8.19e-06358226982350
Pubmed

Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells.

TIMD4 EP300

8.19e-06358226899911
Pubmed

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis.

MSH2 REV1

8.19e-06358222810206
Pubmed

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

HYOU1 RTN3

8.19e-06358231176671
Pubmed

DNA polymerase ι is acetylated in response to SN2 alkylating agents.

EP300 REV1

8.19e-06358230886224
Pubmed

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.

MSH2 REV1

8.19e-06358223140944
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

LIG3 MXRA5 AP1B1 BCL9 RFX1 MAML3 EP300 RYR1

1.05e-0563858831182584
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

HYOU1 AP1B1 RBM27 PPME1 MSH2 BCL9 RFX1 CIT SNRPD3 EP300

1.29e-051103581034189442
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

HK1 HYOU1 AP1B1 KIF1A LRRC40 YARS1

1.65e-0532358624797263
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

LIG3 HK1 HYOU1 AP1B1 RBM27 POLD3 SNRPD3 YTHDF2 CNN3 YARS1

1.84e-051149581035446349
Pubmed

Regulation of autophagy by the p300 acetyltransferase.

ATG7 EP300

2.72e-05558219124466
Pubmed

Aristaless Related Homeobox (ARX) Interacts with β-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling.

BCL9 EP300

2.72e-05558228103279
Pubmed

Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery.

PPFIA1 RYR1

2.72e-05558228831123
Pubmed

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells.

TIMD4 ATG7

2.72e-05558221969579
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

ARFGEF3 PPFIA1 AKAP13 EP300

2.83e-0510458431240132
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

NEO1 HYOU1 PPFIA1 AKAP3 ANKRD28 AKAP13 POLD3 YTHDF2

2.84e-0573358834672954
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

LIG3 RBM27 COX4I1 WWP2 ANKRD28 MSH2 EP300

2.92e-0553358725544563
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

HYOU1 AP1B1 LRRC40 MSH2 POLD3 YTHDF2 YARS1

2.95e-0553458735032548
Pubmed

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.

HK1 AP1B1 COX4I1 RTN3 YTHDF2 CNN3 YARS1

3.65e-0555258736293380
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

LIG3 HYOU1 PTPRE PPM1D PPFIA1 PPME1 ANKRD28

4.62e-0557358728330616
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

SLC25A27 HYOU1 ATG7 COX4I1 PLEKHO1 SNRPD3 YTHDF2 HEPH RYR1 REV1

5.00e-051293581015342556
Pubmed

Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.

MSH2 REV1

5.71e-05758224038355
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

LGMN HYOU1 ASAH1 ANKRD28 ITGA2B YTHDF2 HEPH

7.05e-0561358722268729
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

CRYBG2 JOSD1 AKAP13 CFAP43 BCL9 TESK1 CIT EP300 RYR1

8.39e-05110558935748872
Pubmed

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.

LIG3 POLD3

9.77e-05958220227374
Pubmed

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.

ATG7 EP300

9.77e-05958229033323
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

RBM27 MSH2 BCL9 MAML3 EP300 YTHDF2

1.13e-0445758632344865
Pubmed

Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome.

LIG3 AP1B1

1.22e-041058212383505
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NEO1 HK1 HYOU1 COX4I1 WWP2 PPFIA1 RTN3 ANKRD28 AKAP13 LRRC40

1.59e-041487581033957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ARFGEF3 PTPRE KIF1A ATG7 WWP2 CDYL2 RTN3 AKAP13 MAML3 EP300

1.60e-041489581028611215
Pubmed

140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.

ARFGEF3 PTPRE AP1B1 RTN3

1.62e-0416358416512683
Pubmed

Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa.

HK1 AKAP3

1.78e-041258216687649
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

PPME1 CIT YTHDF2 CNN3 YARS1

1.83e-0431558526777405
Pubmed

Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.

ASAH1 ITGA2B DMAC2L

1.95e-046758316806233
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

HK1 HYOU1 RBM27 MSH2

2.32e-0417958436261009
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

LIG3 AP1B1 RBM27 MSH2 YTHDF2

2.60e-0434058524332808
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

LIG3 PPM1D MSH2 RFX1 SNRPD3

2.63e-0434158532971831
Pubmed

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.

TIMD4 ATG7

2.83e-041558230245008
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

ARFGEF3 AP1B1 KIF1A PPFIA1 RYR1 REV1

3.13e-0455258610737800
Pubmed

Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.

PPFIA1 AKAP13 CIT

3.18e-047958329121065
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

HYOU1 PTPRE PPM1D COX4I1 PPFIA1 PPME1 ANKRD28 MSH2

3.36e-04104958827880917
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

HK1 AP1B1 ANKRD28 LRRC40 RFX1 CNN3

3.38e-0456058635241646
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

LIG3 HK1 ANKRD28 AKAP13 LRRC40 MSH2 POLD3 SNRPD3 YTHDF2

3.80e-04135358929467282
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

LIG3 AP1B1 LRRC40 YTHDF2 CNN3

3.83e-0437058522922362
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

AP1B1 PPM1D PPFIA1 LRRC40 MSH2 SNRPD3

4.14e-0458258620467437
Pubmed

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

AP1B1 PPME1 MSH2

4.66e-049058328978906
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

LIG3 HK1 AP1B1 MSH2 CIT SNRPD3 YTHDF2

5.06e-0484758735235311
Pubmed

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

HK1 HYOU1 AP1B1 MSH2 YARS1

5.27e-0439758521319273
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ARFGEF3 STARD9 WWP2 PPFIA1 AKAP13 TESK1 YTHDF2

5.58e-0486158736931259
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

LIG3 RTN3 AKAP13 CIT

5.60e-0422658437839992
Pubmed

Human transcription factor protein interaction networks.

LIG3 RBM27 COX4I1 ANKRD28 BCL9 RFX1 CIT EP300 YTHDF2

5.64e-04142958935140242
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

ARFGEF3 NEO1 COX4I1 RTN3 ANKRD28 POLD3 CIT YARS1

5.79e-04113958836417873
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

ARFGEF3 LIG3 HK1 HYOU1 COX4I1 ANKRD28 MSH2 SNRPD3 YTHDF2

5.96e-04144058930833792
Pubmed

Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.

ATG7 RTN3

6.18e-042258237225996
Pubmed

Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.

MSH2 POLD3

6.18e-042258222902628
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

DNAAF2 HYOU1 AP1B1 ATG7 PPME1 MSH2 YARS1

6.26e-0487858737223481
Pubmed

Defining the membrane proteome of NK cells.

HYOU1 COX4I1 WWP2 JOSD1 AKAP13 LRRC40 MSH2 CIT

6.83e-04116858819946888
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

LIG3 HYOU1 AP1B1 ANKRD28 AKAP13 YTHDF2

7.39e-0465058638777146
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

HK1 AP1B1 RBM27 MSH2 EP300 CNN3

7.57e-0465358633742100
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

HK1 HYOU1 AP1B1 KIF1A ANKRD28 MSH2

7.57e-0465358622586326
Pubmed

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.

KIF1A STARD9

8.00e-04255829275178
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

ARFGEF3 RBM27 PPFIA1 MSH2

8.28e-0425158429778605
Pubmed

Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.

LIG3 MSH2

8.66e-042658220731661
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

COX4I1 ANKRD28 ZFP69B BCL9 SNRPD3 EP300 CNN3 HEPH

8.82e-04121558815146197
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

LIG3 RBM27 PPME1 ANKRD28 SNRPD3 YTHDF2 CNN3

9.00e-0493458733916271
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

NEO1 HYOU1 ASAH1 ITGA2B

9.03e-0425758416335952
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

ARFGEF3 HYOU1 AP1B1 KIF1A RTN3 LRRC40 MSH2

9.45e-0494258731073040
Pubmed

Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.

LIG3 REV1

1.00e-032858219661089
Pubmed

A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.

MSH2 POLD3

1.23e-033158212171929
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

HYOU1 RBM27 PPFIA1 AKAP13 YTHDF2 CNN3

1.29e-0372458636232890
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

RTN3 AKAP13 SNRPD3 EP300

1.29e-0328358418854154
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

LGMN LIG3 AP1B1 MSH2 YTHDF2

1.30e-0348658530940648
Pubmed

Primary Ciliary Dyskinesia

DNAAF2 NME8

1.31e-033258220301301
Pubmed

KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.

RBM27 PPFIA1 YTHDF2

1.36e-0313058335545047
Pubmed

Comprehensive Proteomic Analysis of PGC7-Interacting Proteins.

HK1 HYOU1 STARD9 SNRPD3

1.36e-0328758428712289
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

LIG3 HK1 WWP2 CIT YTHDF2 RYR1

1.36e-0373258634732716
Pubmed

Lynch Syndrome

MSH2 EP300

1.40e-033358220301390
Pubmed

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.

HK1 AP1B1

1.40e-033358226025364
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

LIG3 MXRA5 KIF1A AKAP13 LRRC40 RYR1

1.40e-0373658629676528
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

LIG3 ATG7 RBM27 MSH2 POLD3 EP300 YARS1

1.45e-03101458732416067
Pubmed

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

PPM1D SNRPD3

1.48e-033458211101529
Pubmed

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

KIF1A ATG7

1.48e-033458225915474
Pubmed

SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.

MSH2 HEPH

1.48e-033458231495888
Pubmed

HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis.

HK1 HYOU1 ASAH1

1.51e-0313558323874603
Pubmed

Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.

ATG7 KLB

1.57e-033558230818059
InteractionRPA4 interactions

ARFGEF3 LIG3 RBM27 STARD9 COX4I1 MSH2 POLD3 SNRPD3 YTHDF2 CNN3

5.81e-074525810int:RPA4
Cytoband14q21.3

DNAAF2 DMAC2L

5.40e-042758214q21.3
CytobandEnsembl 112 genes in cytogenetic band chr11q13

PPFIA1 PPME1 RTN3 POLD3

2.63e-03454584chr11q13
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARFGEF3 ANKRD28 ITGA2B POLD3 RYR1

4.71e-05181405694
GeneFamilyDNA polymerases

POLD3 REV1

1.17e-0323402535
GeneFamilyZinc fingers MYND-type|A-kinase anchoring proteins

AKAP3 AKAP13

1.87e-0329402396
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF1A STARD9

4.64e-0346402622
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

KIF1A AKAP13 PLEKHO1

1.06e-02206403682
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_k-means-cluster#1_top-relative-expression-ranked_1000

HYOU1 PTPRE WWP2 PPFIA1 REV1

1.49e-05114585gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_k1_1000
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE TIMD4 AP1B1 RYR1

4.62e-06188585cb091912f9b627a78a8793a37df7f1de839f887f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN PTPRE ATG7 PLEKHO1 RYR1

5.52e-0619558542bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN PTPRE ATG7 MAML3 RYR1

5.81e-061975858af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellwk_08-11-Hematologic-Myeloid-SPP1+_Mac|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LGMN PTPRE TIMD4 AP1B1 RYR1

6.10e-06199585d94cf750599366061066074e8007d707adf6fc5a
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PTPRE AP1B1 AKAP13 MAML3 RYR1

6.25e-0620058521bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PTPRE AP1B1 AKAP13 MAML3 RYR1

6.25e-06200585a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PTPRE AP1B1 AKAP13 MAML3 RYR1

6.25e-06200585dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PTPRE AP1B1 AKAP13 MAML3 RYR1

6.25e-06200585a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PTPRE AP1B1 AKAP13 MAML3 RYR1

6.25e-062005853bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

PTPRE AP1B1 AKAP13 MAML3 RYR1

6.25e-0620058533036d21c1c82109284473a515c4f890b33fdd5c
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|367C / Donor, Lineage, Cell class and subclass (all cells)

PPIP5K1 MSH2 BCL9 RYR1

2.58e-05131584aeeb5718b3a7122492ad2659d5c8112f60839ff3
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-2|TCGA-Lung / Sample_Type by Project: Shred V9

KIF1A RTN3 MSH2 POLD3

5.36e-051585849dea15b28f64206bac0e785df6f36a2cc9010ac7
ToppCelldroplet-Fat-Gat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN TIMD4 AP1B1 PLEKHO1

5.91e-05162584052f797d8bcab8fc6a43e0bffdd215c88ee12889
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

LGMN KIF1A XIRP2 PLEKHO1

6.19e-05164584362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCellNS-critical-d_0-4-Myeloid-Monocyte-derived_DC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LGMN TIMD4 ZFP69B NME8

6.96e-051695846fe82db874eff0f86e5c0d1cc81322eb9d7874eb
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRE TIMD4 PLEKHO1 RYR1

7.45e-051725840c0ae2da3cba6022403434567800f16e61a34a2b
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRE TIMD4 PLEKHO1 RYR1

7.45e-05172584d80c207f3489be2da2f40f47a7835cb73c949c3e
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRE TIMD4 PLEKHO1 RYR1

7.45e-051725846b01448443cf8392ed8248ff452b80c31240b85d
ToppCellE12.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HK1 KIF1A STARD9 ITGA2B

7.45e-051725843b9be685fcd1634498a603b692f5ac6ddd0de176
ToppCelldroplet-Liver-Npc-18m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LGMN TIMD4 ASAH1 PLEKHO1

7.96e-0517558492a4a3fd323ee8360edd659f9e16dfddc8788e2f
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LGMN PTPRE TIMD4 ASAH1

8.14e-05176584adb679e69c0c17f0caee4c141bac55d03c963012
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LGMN PTPRE TIMD4 ASAH1

8.32e-05177584ab92ffc9624850a50c88e6b8f3a517ff2251ff15
ToppCell3'_v3|World / Manually curated celltypes from each tissue

JOSD1 ANKRD28 AKAP13 SNRPD3

8.51e-0517858442502f14d9c756df8104900ac6484477b885d3d9
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PPME1 MSH2 ANKRD6 CIT

1.01e-04186584799903b68bc6f6205d004b44c603424b0d5f7c32
ToppCell5'-Adult-LymphNode-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE ASAH1 RYR1

1.03e-0418758400930e407beaa337f72533a69f32d150faad8b9a
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LGMN PTPRE AP1B1 RYR1

1.05e-041885843be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

LGMN AP1B1 ATG7 RYR1

1.09e-04190584f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN PTPRE PLEKHO1 RYR1

1.12e-0419158451f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN PTPRE PLEKHO1 RYR1

1.12e-04191584baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN PTPRE PLEKHO1 RYR1

1.12e-041915848fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCellControl-Myeloid-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

LGMN AP1B1 ATG7 RYR1

1.16e-04193584a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

LGMN AP1B1 PLEKHO1 RYR1

1.16e-0419358431c0978ba78c9516d498aec0798902e57555e557
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGMN PTPRE AP1B1 PLEKHO1

1.19e-041945847b6a34d1f8922b71dcc931421666c1822cec8345
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE ASAH1 RYR1

1.19e-041945847c7091de47359760003e910cfbe63db5c99410d6
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGMN PTPRE AP1B1 PLEKHO1

1.19e-04194584435406ebe626c702f7d5a99a3d68ee85aa09be95
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGMN PTPRE AP1B1 PLEKHO1

1.19e-0419458448c37251518f96524807b5bd1bbc2820637666ad
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN AP1B1 ATG7 RYR1

1.19e-0419458445708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellMonocytes-C1QA+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

LGMN TIMD4 AP1B1 PLEKHO1

1.19e-041945843e104e85574894c04791252d466d438fc809dde3
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

LGMN AP1B1 ATG7 ASAH1

1.21e-04195584c172c5599379c29123340621a36bfb1fc90c2115
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARFGEF3 HYOU1 AP1B1 KIF1A

1.21e-04195584bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LGMN PTPRE PLEKHO1 RYR1

1.21e-0419558409df40ff9b493170861b3f6e57a942a834655b5c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DNAAF2 TIMD4 POLD3 CIT

1.23e-04196584de70cc301a8cbaedb0a5ea4a6442dcdaa477822d
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN TIMD4 AP1B1 RYR1

1.26e-041975841c0024049db2d2c817a7f503de235b9630b24e33
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE TIMD4 AP1B1

1.26e-04197584759f26753f76af3ae8d8527c4d221206245a3d45
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-NK_CD56bright|ICU-SEP / Disease, condition lineage and cell class

PPFIA1 MSH2 ITGA2B ZFP69B

1.26e-04197584c187e3fc2160b0165eb039cf09a6e621016068b7
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LGMN TIMD4 AP1B1 ASAH1

1.26e-0419758472775eb6c24cfb956436642ac9cd6e4d5c01ea5f
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGMN PTPRE AP1B1 PLEKHO1

1.26e-04197584515a2d0ee2bd3fc0a5a0c315e2b0c752e6af7406
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGMN PTPRE AP1B1 PLEKHO1

1.26e-041975844fccdc69ab4b966de6465f06677435e6f6e6abcd
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LGMN PTPRE AP1B1 PLEKHO1

1.26e-04197584bfa04e5f4156a01df4217b1f59676edb0a7563e1
ToppCellLAM-Epithelial-AT2|Epithelial / Condition, Lineage and Cell class

LGMN ASAH1 ANKRD28 AKAP13

1.26e-0419758427e6eb7bbc27e7635df1aae7c7d75f8a3f1b1cc2
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE TIMD4 AP1B1

1.28e-04198584acb84681569651447d684aa3960f0510d7ff17e8
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

WDR93 KIF1A AKAP3 CIT

1.28e-04198584d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCellwk_20-22-Hematologic-Myeloid-SPP1+_Mac|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

LGMN AP1B1 ASAH1 RYR1

1.31e-041995847c19f1b1f4369edd035ca9cdcf4e653771fc4648
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE AP1B1 RYR1

1.31e-04199584f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HK1 PTPRE AKAP13 MAML3

1.31e-04199584379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRE AP1B1 AKAP13 PLEKHO1

1.31e-04199584b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGMN PTPRE PLEKHO1 RYR1

1.31e-041995849545ac59c8d75f5747dff86cb511a149dc103b31
ToppCellnormal_Lung-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

LGMN HYOU1 PTPRE AKAP13

1.31e-041995842f6074a2fd3323f258be03042f77929640ad0a75
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LGMN PTPRE AP1B1 RYR1

1.31e-041995845ceeed92f831d068ff4bb3994f420002338330e7
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGMN PTPRE PLEKHO1 RYR1

1.33e-04200584f3dc07a7cc8cf041da8fe610d21af595818cf2d8
ToppCellcontrol-cDC|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

LGMN PTPRE PLEKHO1 RYR1

1.33e-042005844a6d17a4225be38537d3dd8a39512051f597f4e0
ToppCellmild-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PTPRE ASAH1 ANKRD28 PLEKHO1

1.33e-04200584934c2efc780318c66d667ca75be0de350361d351
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRE JOSD1 AKAP13 TESK1

1.33e-04200584838f87cc55652512d240c5952ee4b3870fb2399f
ToppCellSevere-Myeloid-Macrophages|Severe / Condition, Lineage, Cell class and cell subclass

LGMN PTPRE ASAH1 PLEKHO1

1.33e-04200584ee1d80fa5d4609f9a6b10c33950e888f509a063c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LGMN PTPRE AP1B1 AKAP13

1.33e-0420058474ceebee9af63f8b3ec5857eff1b662752bc3862
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate|GW23 / Sample Type, Dataset, Time_group, and Cell type.

WDR93 MXRA5 MSH2 KLB

1.33e-04200584fe772d98c461c973dfc082e1fc50117c27ced804
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LGMN TIMD4 AP1B1 ASAH1

1.33e-04200584af743dfef7e7cfaef1c494999757123f93a213e3
Diseaseosteoarthritis, knee

ATG7 WWP2 POLD3 ANKRD6 EP300

1.27e-05158565EFO_0004616
Diseasesystemic lupus erythematosus (implicated_via_orthology)

TIMD4 ATG7 EP300

7.57e-0543563DOID:9074 (implicated_via_orthology)
Diseasenervous system disease (implicated_via_orthology)

KIF1A ATG7

2.31e-0412562DOID:863 (implicated_via_orthology)
Diseasecytotoxicity measurement, response to metformin

KIF1A POLD3

7.26e-0421562EFO_0006952, GO_1901558
DiseaseBronchiectasis

DNAAF2 NME8

7.98e-0422562C0006267
Diseasegamma-glutamylglutamine measurement

PPM1D MAML3

7.98e-0422562EFO_0021138
Diseasecongestive heart failure (is_implicated_in)

EP300 RYR1

1.20e-0327562DOID:6000 (is_implicated_in)
DiseaseBreast Cancer, Familial

PPM1D MSH2

1.49e-0330562C0346153

Protein segments in the cluster

PeptideGeneStartEntry
MSQTSLKQKKNEPGM

NT5C1B

1

Q96P26
GLINSMVKSPMTQAG

EP300

116

Q09472
ILCKKSQPGMDVNQM

CFAP43

146

Q8NDM7
TLKMKQGPMTQAINR

AKAP13

1376

Q12802
GKTPLMMAAENGQTN

ANKRD28

856

O15084
GSVMKMEPLNNLQVA

AP1B1

801

Q10567
KNMINTFVPSGKIMQ

ASAH1

81

Q13510
MMPFGKISQQLCGVK

DMAC2L

16

Q99766
MNSNKMVNAKLPIGT

CIT

246

O14578
GMDMKTCTQPQAGVK

ARMCX4

541

Q5H9R4
LGSVQDKMNTKLGQM

ANKRD6

436

Q9Y2G4
GGIQKMMSKPQTSGA

RBM27

726

Q9P2N5
TIGQMQGKFQMQVLP

PPME1

331

Q9Y570
ENMRTGNLPANMKKA

PTPRE

441

P23469
GSQPQAAIMKQMLID

MAML3

731

Q96JK9
SQMILGKSQQPESKM

DNAAF2

736

Q9NVR5
QPKKMQMDGNVSGTQ

PPFIA1

1176

Q13136
NTMVTPHKKSMLGNG

JOSD1

66

Q15040
TVMDQKNLKMSTPGQ

PPM1D

506

O15297
DGNMQTAKPSAMKVG

LIG3

891

P49916
LNPGKQLFEKMVSGM

HK1

286

P19367
QMVKTKEAGMQPQLQ

HYOU1

246

Q9Y4L1
KNQKGGMGPRMVNLS

ATG7

306

O95352
IQAMMAQSQSLGKGP

BCL9

406

O00512
MVPSGMKGDVNLNVN

BCL9

711

O00512
APGVMKDFMKQVQTS

ARFGEF3

761

Q5TH69
LKNQMAPTMSLQVIG

CRYBG2

1576

Q8N1P7
PNNFKPLNTMAKMGQ

KLB

376

Q86Z14
QTKRMLDMKVNPIQG

COX4I1

141

P13073
GKQKNIMPLSAAMFQ

RYR1

1566

P21817
KQMFHIITGPNMGGK

MSH2

661

P43246
TMMGKQEKDQQGIIP

KIF1A

106

Q12756
SNNQVGSVDPQKMKM

LRRC40

526

Q9H9A6
DMKKMEKPQGTSNNV

RTN3

126

O95197
LKPQKMRGVESQGML

YARS1

426

P54577
KPIQKMEGMTNGVAV

RFX1

541

P22670
GNVKMLGMQIPIKNV

HEPH

1091

Q9BQS7
KIQARNSKGMGPMSE

NEO1

1031

Q92859
MGVKQPHQMVSQGLA

STARD9

936

Q9P2P6
ASKQVSQQPKGIMGM

POLD3

181

Q15054
SQQPKGIMGMFASKA

POLD3

186

Q15054
GNPMKKNAQIGIAML

ITGA2B

721

P08514
MMKKNNSAKRGPQDG

PLEKHO1

1

Q53GL0
GMGDPKNRNVNFAMK

AKAP3

411

O75969
IMPLKKSQNGMENGD

CDYL2

146

Q8N8U2
QMGTNKVASQKGMSV

CNN3

246

Q15417
QTAMMSSKTGKPGNK

XIRP2

2856

A4UGR9
VLKNNGGKMENMQLT

WWP2

106

O00308
QVTPGMMKNKQDSLQ

NME8

261

Q8N427
MAKLQKEFGPKTGQM

REV1

676

Q9UBZ9
NPTDLVKVQMQMEGK

SLC25A27

146

O95847
QVMVLKMNKLPSNRG

TESK1

81

Q15569
PMLKSMKNKNQGSGA

SNRPD3

81

P62318
NQRMGKGQIPLMCKK

ZFP69B

201

Q9UJL9
KGQNMYPEGQVKSQM

WDR93

471

Q6P2C0
MGSKLSPGAQQLINM

nan

31

Q499Y3
NKTTKTGQMDGIPMS

TIMD4

291

Q96H15
TPILVQMVKSANMNG

PPIP5K1

601

Q6PFW1
LNKAPGMNTIDQGMA

YTHDF2

176

Q9Y5A9
GNKTISTMKVMQFQG

LGMN

271

Q99538
IKKGMKEMSQTLQGG

MXRA5

1056

Q9NR99