Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H2A kinase activity	DCAF1 BUB1	1.49e-05	3	45	2	GO:0140995
GeneOntologyMolecularFunction	nuclear receptor binding	DCAF1 PRAMEF33 PRAMEF10 MED12	8.22e-04	187	45	4	GO:0016922
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	DCAF1 PRAMEF33 PRAMEF10	8.36e-04	82	45	3	GO:1990756
GeneOntologyMolecularFunction	enzyme-substrate adaptor activity	DCAF1 PRAMEF33 PRAMEF10	1.28e-03	95	45	3	GO:0140767
GeneOntologyMolecularFunction	histone kinase activity	DCAF1 BUB1	1.81e-03	28	45	2	GO:0035173
GeneOntologyMolecularFunction	transporter activity	SLC35E2B ATP11B KCNB1 SLC2A1 SLC35E2A SLC43A1 SLC25A31 CFTR NPC1L1	2.03e-03	1289	45	9	GO:0005215
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	DCAF1 PRAMEF33 PRAMEF10 LDB1 MED12	2.38e-03	417	45	5	GO:0061629
Domain	Sugar_P_trans_dom	SLC35E2B SLC35E2A	2.41e-04	10	44	2	IPR004853
Domain	TPT	SLC35E2B SLC35E2A	2.41e-04	10	44	2	PF03151
Domain	G_patch	CMTR1 SUGP2	1.33e-03	23	44	2	SM00443
Domain	G_patch_dom	CMTR1 SUGP2	1.33e-03	23	44	2	IPR000467
Domain	G-patch	CMTR1 SUGP2	1.33e-03	23	44	2	PF01585
Domain	G_PATCH	CMTR1 SUGP2	1.33e-03	23	44	2	PS50174
Pubmed	Kv2 channels do not function as canonical delayed rectifiers in spinal motoneurons.	CHAT KCNB1	1.64e-06	2	45	2	39148717
Pubmed	SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.	SLC35E2B SLC35E2A	1.64e-06	2	45	2	35247439
Pubmed	Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading.	PDK4 SLC2A1	1.63e-05	5	45	2	12145475
Pubmed	The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins.	NUP98 BUB1	1.63e-05	5	45	2	11352911
Pubmed	Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.	CHAT NRXN2	1.63e-05	5	45	2	9223334
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	ANKK1 MYH4	3.42e-05	7	45	2	29758057
Pubmed	The RNA-binding protein Celf6 is highly expressed in diencephalic nuclei and neuromodulatory cell populations of the mouse brain.	CHAT HDC	3.42e-05	7	45	2	25682262
Pubmed	Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.	CHAT KCNB1	3.42e-05	7	45	2	28504671
Pubmed	Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit.	CHAT HDC	3.42e-05	7	45	2	31178114
Pubmed	Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes.	CHAT LDB1	4.56e-05	8	45	2	24763339
Pubmed	Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation.	PNPLA1 SLC2A1	4.56e-05	8	45	2	36662623
Pubmed	Molecular and genetic characterization of GABP beta.	SLC2A1 HDC	1.07e-04	12	45	2	7958862
Pubmed	The contribution of rare and common variants in 30 genes to risk nicotine dependence.	ANKK1 NRXN2	1.47e-04	14	45	2	25450229
Pubmed	Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis.	SLC2A1 SLC43A1	2.20e-04	17	45	2	39147774
Pubmed	A cluster of cholinergic premotor interneurons modulates mouse locomotor activity.	CHAT KCNB1	2.20e-04	17	45	2	20005822
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF33 PRAMEF10	3.06e-04	20	45	2	26694250
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	CMTR1 SUGP2 MED12 SRGAP1 SLC25A31	3.19e-04	462	45	5	31138677
Pubmed	Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon.	CHAT LDB1	3.38e-04	21	45	2	24157949
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF33 PRAMEF10	3.72e-04	22	45	2	31729367
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF33 PRAMEF10	4.82e-04	25	45	2	37451217
Pubmed	The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons.	CHAT KCNB1	6.06e-04	28	45	2	32038174
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF33 PRAMEF10	6.06e-04	28	45	2	25089626
Pubmed	TRIM28 modulates nuclear receptor signaling to regulate uterine function.	CFTR HDC	6.96e-04	30	45	2	37528140
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF33 PRAMEF10	6.96e-04	30	45	2	38786026
Pubmed	Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	CHAT LDB1	6.96e-04	30	45	2	30127719
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF33 PRAMEF10	9.48e-04	35	45	2	19389355
Pubmed	Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.	PDK4 SLC2A1	1.12e-03	38	45	2	20185832
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH4 MED12	1.18e-03	39	45	2	38690566
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	NUP98 DCAF1 KIAA1217 DARS2	1.20e-03	360	45	4	33111431
Cytoband	10p12.31	MALRD1 KIAA1217	2.24e-04	22	46	2	10p12.31
GeneFamily	Solute carriers	SLC35E2B SLC2A1 SLC35E2A SLC43A1 SLC25A31	4.41e-04	395	30	5	752
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	CMTR1 SUGP2	6.02e-04	22	30	2	579
Coexpression	DESCARTES_FETAL_EYE_PDE11A_FAM19A2_POSITIVE_CELLS	CHAT HDC PDE11A	1.56e-05	29	44	3	M40183
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary\|LPS_only / Treatment groups by lineage, cell group, cell type	PRXL2A ATP11B SLC2A1 SLC43A1 BUB1	1.75e-06	200	45	5	ce8281c9556a1f64f8ca8a029110077d4ef5b35e
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_only / Treatment groups by lineage, cell group, cell type	PRXL2A ATP11B SLC2A1 SLC43A1 BUB1	1.75e-06	200	45	5	83c4181c083b364f0d3a89ae7a0504781fa9fa9f
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_only / Treatment groups by lineage, cell group, cell type	PRXL2A ATP11B SLC2A1 SLC43A1 BUB1	1.75e-06	200	45	5	f15baf287ec467664c23faa53fdea45257f7b9d0
ToppCell	3'-Adult-SmallIntestine-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MALRD1 FOLH1 PDK4 NPC1L1	3.54e-05	184	45	4	ed7a8e79e5723a5f5a03f542203d9e50bdef5f50
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRXL2A ATP11B SLC2A1 SLC43A1	3.69e-05	186	45	4	affc246a1091e44dc85a5e237c778a7541d5a2b4
ToppCell	LPS_only-Hematopoietic_Meg-Ery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRXL2A ATP11B SLC2A1 SLC43A1	3.69e-05	186	45	4	40d1e15402fdfb3b5ae850a2070cd4b68fda3159
ToppCell	LPS_only-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRXL2A ATP11B SLC2A1 SLC43A1	3.69e-05	186	45	4	e5014443e9d6e25943308483e20d48b776ae5373
ToppCell	3'-Adult-SmallIntestine-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MALRD1 FOLH1 PDK4 NPC1L1	3.69e-05	186	45	4	bdd9d3a432aab46e733469b362f0064d35c1ac49
ToppCell	3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MALRD1 FOLH1 PDK4 NPC1L1	3.77e-05	187	45	4	9042bd0f57213a51503d9df2e4dce3209b7772d3
ToppCell	10x3'2.3-week_14-16-Endothelial-stroma-immature_EC\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PRXL2A FOLH1 PDK4 SRGAP1	4.18e-05	192	45	4	5af3b2b38495e925497c48f605d618bbf970965d
Disease	Schizophrenia	MC5R ANKK1 CHAT KCNB1 NRXN2 FOLH1 MED12	2.27e-04	883	42	7	C0036341
Disease	Mental Depression	ANKK1 CHAT FOLH1 MED12	4.64e-04	254	42	4	C0011570
Disease	Depressive disorder	ANKK1 CHAT FOLH1 MED12	7.53e-04	289	42	4	C0011581
Disease	Diaphragmatic Hernia	KCNB1 CFTR	1.57e-03	41	42	2	C0019284
Disease	Colorectal Carcinoma	LDB1 FOLH1 CFTR HDC BUB1	3.09e-03	702	42	5	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPLMFMEAFSMRRFE	PRAMEF33	36	A0A0G2JMD5
MEAFSMRRFEALKLM	PRAMEF33	41	A0A0G2JMD5
FQAGLGRMMMKYRDQ	CFTR	236	P13569
QGLVISFAMRMLYMI	BUB1	891	O43683
YSGFNMMMIIIRVAA	ANKK1	226	Q8NFD2
SFFMARVFMRMKLPG	OSTC	131	Q9NRP0
RFYMNRISTRMLMNQ	PDK4	161	Q16654
RVRIFSRFPEDMMML	HDC	611	P19113
IFMQLGSRELMMFYI	DCAF1	346	Q9Y4B6
LLMDMALFMGRSFRV	NUP98	1131	P52948
RLYLEFMFDDMMRIK	LDB1	181	Q86U70
FVNRFGRRNSMLMMN	SLC2A1	86	P11166
GRRNSMLMMNLLAFV	SLC2A1	91	P11166
LRMMNDQLMFLERAF	FOLH1	661	Q04609
MGMTQLRIIFYMAAV	SLC43A1	311	O75387
EMMLLVAMAYDRFIA	OR4K1	111	Q8NGD4
AALRMFMELGMVQKF	PDE11A	626	Q9HCR9
VSLRFMSQRAYGLMM	NRXN2	756	Q9P2S2
MVQMMRQFLYRVLPE	PNPLA1	96	Q8N8W4
MFMFQDGMLDRHEFL	MED12	241	Q93074
EMVLLIAMAFDRYMA	OR4F15	111	Q8NGB8
FLEEMRAFQRRMAGM	NPC1L1	596	Q9UHC9
MLFFLDRMLAFPMNE	MALRD1	1	Q5VYJ5
MMSMLGGLQRYFRVI	GAL3ST2	1	Q9H3Q3
YPFDTVRRRMMMQSG	SLC25A31	241	Q9H0C2
LNFYRTGRLHMMEEM	KCNB1	96	Q14721
EYVTLIMTRGMMFVN	GPRC5D	146	Q9NZD1
SRFMSHFNMYLILIM	MC5R	271	P33032
CYFMERLMARQRPVM	DNAH9	2461	Q9NYC9
MIRGVFFLNRAAMKM	CMTR1	226	Q8N1G2
RLAGFLMQMDRFMIF	RTL6	111	Q6ICC9
LMQMDRFMIFQASRF	RTL6	116	Q6ICC9
FQMQYNLRLRSQMVM	DARS2	181	Q6PI48
IMRFMQISEDSTRMF	SRGAP1	126	Q7Z6B7
MNVRMFSLMVGIFSV	TMEM217B	1	A0A494BZU4
TMNGDMRMQRELVYA	KIAA1217	276	Q5T5P2
NFLMTMLFVGLMRFA	SLC35E2A	141	P0CK97
CRGFLMRVEFRKMME	MYH4	796	Q9Y623
YGPQRRKMMFMGFIR	PRXL2A	141	Q9BRX8
MFMDETYLMSNRFVL	CHAT	641	P28329
MSFRDLRNFTEMMRA	CLUAP1	1	Q96AJ1
DLYRFMGRMIITQQM	ATP11B	216	Q9Y2G3
MRFSVLMQMRFDGLL	NUDT16L1	46	Q9BRJ7
EDTFDVFRQRMMQMY	SUGP2	1061	Q8IX01
FPLMFMEAFSMRRFE	PRAMEF10	36	O60809
MEAFSMRRFEALKLM	PRAMEF10	41	O60809
NFLMTMLFVGLMRFA	SLC35E2B	141	P0CK96
TVMLAFIMYMTLRNA	TMEM130	351	Q8N3G9
DMDSMVRLMRYNDFL	PLBD2	471	Q8NHP8
RNRMVTFYMVMLLEN	XKR5	261	Q6UX68