Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	G_patch	GPATCH2 CMTR1	9.93e-04	23	38	2	SM00443
Domain	G_patch_dom	GPATCH2 CMTR1	9.93e-04	23	38	2	IPR000467
Domain	G-patch	GPATCH2 CMTR1	9.93e-04	23	38	2	PF01585
Domain	G_PATCH	GPATCH2 CMTR1	9.93e-04	23	38	2	PS50174
Domain	Bromodomain_CS	BPTF BRPF3	1.27e-03	26	38	2	IPR018359
Domain	BROMODOMAIN_1	BPTF BRPF3	2.57e-03	37	38	2	PS00633
Domain	Bromodomain	BPTF BRPF3	2.71e-03	38	38	2	PF00439
Domain	BROMODOMAIN_2	BPTF BRPF3	3.14e-03	41	38	2	PS50014
Domain	BROMO	BPTF BRPF3	3.30e-03	42	38	2	SM00297
Domain	Bromodomain	BPTF BRPF3	3.30e-03	42	38	2	IPR001487
Domain	-	BPTF BRPF3	3.30e-03	42	38	2	1.20.920.10
Domain	Zinc_finger_PHD-type_CS	BPTF BRPF3	7.73e-03	65	38	2	IPR019786
Domain	-	SPECC1L CAMSAP2	9.17e-03	71	38	2	1.10.418.10
Domain	CH	SPECC1L CAMSAP2	9.67e-03	73	38	2	PS50021
Domain	PHD	BPTF BRPF3	1.02e-02	75	38	2	PF00628
Domain	CH-domain	SPECC1L CAMSAP2	1.02e-02	75	38	2	IPR001715
Domain	Znf_PHD-finger	BPTF BRPF3	1.13e-02	79	38	2	IPR019787
Domain	PHD	BPTF BRPF3	1.41e-02	89	38	2	SM00249
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ACSL3 BPTF CCT2 SPECC1L EP400 MAP4 RPL7 KRT80 NUP210	1.54e-06	1024	39	9	24711643
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	BPTF MED1 BCOR EP400	2.33e-06	83	39	4	28794006
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	BPTF CCT2 SPECC1L MED1 BCOR EP400 MAP4	2.33e-06	549	39	7	38280479
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	CCT2 SUPT20H BCOR EP400 RPL7 ZNF518A	5.13e-06	398	39	6	35016035
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	ACSL3 CCT2 SPECC1L ADRM1 RPL7 KRT80 NUP210	6.85e-06	647	39	7	26618866
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CCT2 MED1 BCOR EP400 MAP4 CAMSAP2 ARHGAP21 RPL7	7.72e-06	934	39	8	33916271
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SUPT20H MED1 CMTR1 BCOR EP400 MAP4	9.56e-06	444	39	6	34795231
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	ACSL3 CCT2 SPECC1L MAP4	1.30e-05	128	39	4	28027390
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SRP19 BPTF CCT2 SPAST MED1 BCOR EP400 MAP4	2.56e-05	1103	39	8	34189442
Pubmed	Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.	CCT2 MAP4 ADRM1 RPL7	2.76e-05	155	39	4	22673621
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GPATCH2 BPTF EP400P1 BRPF3 SUPT20H BCOR EP400 ZNF518A	2.78e-05	1116	39	8	31753913
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SRP19 SPECC1L SUPT20H MED1 BCOR EP400 INTS2 MAP4 CAMSAP2	3.26e-05	1497	39	9	31527615
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	SRP19 H2BC1 CCT2 MED1 MAP4 RPL7 KRT80 NUP210	3.51e-05	1153	39	8	29845934
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	BPTF MED1 CMTR1 EP400 NUP210	3.85e-05	341	39	5	32971831
Pubmed	RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma.	SPECC1L MAP4 RPL7	4.71e-05	62	39	3	35568845
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	CCT2 CMTR1 BCOR EP400 RPL7	4.79e-05	357	39	5	37059091
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	BCOR MAP4 CAMSAP2 RPL7	5.40e-05	184	39	4	32908313
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	CCT2 SPECC1L MAP4 RPL7	6.24e-05	191	39	4	33762435
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	SPECC1L MED1 MAP4 NUP210	7.75e-05	202	39	4	33005030
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ACSL3 BPTF SUPT20H MED1 BCOR EP400 INTS2 RPL7	7.90e-05	1294	39	8	30804502
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ACSL3 BPTF CCT2 MAP4 RPL7 NUP210	8.24e-05	653	39	6	22586326
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	MED1 BCOR NUP210	9.36e-05	78	39	3	28611094
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ACSL3 CCT2 BCOR MAP4	9.86e-05	215	39	4	35973513
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	BPTF CCT2 SUPT20H MED1 EP400 MAP4 ADRM1	1.19e-04	1014	39	7	32416067
Pubmed	Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.	WDFY4 LGALS2	1.65e-04	17	39	2	22041458
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL3 H2BC1 BPTF CCT2 PLA2G4D CAMSAP2 ARHGAP21 FER1L6	1.67e-04	1442	39	8	35575683
Pubmed	Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).	ACSL3 CCT2 RNF103 MAP4	1.68e-04	247	39	4	39238192
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	BPTF MED1 CMTR1 EP400 ARHGAP21	1.77e-04	472	39	5	38943005
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ACSL3 H2BC1 EP400 ADRM1 ARHGAP21 NUP210	1.80e-04	754	39	6	35906200
Pubmed	Transcript profiling during preimplantation mouse development.	PSG8 RNF103	1.85e-04	18	39	2	15282163
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	ACSL3 SPECC1L ADRM1 RPL7 NUP210	1.86e-04	477	39	5	31300519
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ACSL3 BPTF MED1 BCOR EP400 MAP4	2.08e-04	774	39	6	15302935
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	BPTF CCT2 MAP4 ADRM1 RPL7	2.19e-04	494	39	5	26831064
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	ACSL3 SPAST MAP4 ARHGAP21 RPL7	2.27e-04	498	39	5	36634849
Pubmed	H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization.	H2BC1 EP400	2.54e-04	21	39	2	22467210
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	ACSL3 RPL7 NUP210	2.80e-04	113	39	3	30352685
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BPTF MED1 EP400 MAP4	2.82e-04	283	39	4	30585729
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BRPF3 SPAST BCOR EP400 INTS2	3.00e-04	529	39	5	14621295
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	H2BC1 CCT2 MAP4 RPL7	3.30e-04	295	39	4	26209609
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	ACSL3 CCT2 NUP210	3.34e-04	120	39	3	37929963
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	CCT2 BCOR MAP4	3.59e-04	123	39	3	26912792
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	ACSL3 MAP4 RPL7 KRT80	4.08e-04	312	39	4	37120454
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	CCT2 SPECC1L MAP4 ADRM1 RPL7 KRT80 NUP210	4.42e-04	1257	39	7	36526897
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SUPT20H MED1 EP400	4.62e-04	134	39	3	25452129
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	BPTF CCT2 EP400 MAP4	5.15e-04	332	39	4	32786267
Pubmed	Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.	CCT2 SPECC1L MAP4 ADRM1	5.27e-04	334	39	4	30425250
Pubmed	rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.	MED1 MAP4 ADRM1	5.47e-04	142	39	3	30217970
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BPTF BCOR EP400	5.93e-04	146	39	3	23892456
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	H2BC1 BPTF MED1 BCOR EP400 MAP4	6.31e-04	954	39	6	36373674
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	SRP19 H2BC1 CCT2 SPECC1L BCOR ADRM1 RPL7	6.33e-04	1335	39	7	29229926
Pubmed	Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.	MAP4 RPL7	6.72e-04	34	39	2	20391533
Pubmed	Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.	SPECC1L CAMSAP2 ARHGAP21 RPL7	7.05e-04	361	39	4	30344098
Pubmed	Diversification of stem cell molecular repertoire by alternative splicing.	WDFY4 NUP210	7.12e-04	35	39	2	16183747
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	CCT2 MAP4 RPL7	7.19e-04	156	39	3	32850835
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	GPATCH2 SRP19 SPECC1L MED1 EP400 MAP4 RPL7	7.41e-04	1371	39	7	36244648
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	FZD6 ACSL3 CMTR1 MAP4 ADRM1	7.80e-04	653	39	5	33742100
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	H2BC1 BPTF CCT2 RPL7	8.70e-04	382	39	4	37249651
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	BPTF MED1 EP400	8.75e-04	167	39	3	20362541
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	SPECC1L MED1 MAP4 ADRM1 NUP210	1.07e-03	701	39	5	30196744
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	CCT2 BCOR	1.07e-03	43	39	2	26487511
Interaction	FGF11 interactions	GPATCH2 ACSL3 CCT2 SPECC1L MAP4	1.41e-05	170	37	5	int:FGF11
Cytoband	12q24.33	EP400P1 EP400	7.74e-04	48	39	2	12q24.33
Cytoband	Ensembl 112 genes in cytogenetic band chr17q24	BPTF ABCA9	3.17e-03	98	39	2	chr17q24
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	GPATCH2 CMTR1	6.86e-04	22	32	2	579
Disease	alcohol dependence measurement	BPTF ARHGAP21	2.06e-03	55	36	2	EFO_0007835
Disease	Disorder of eye	TTC21B BCOR CDHR1	2.19e-03	212	36	3	C0015397
Disease	seasonal gut microbiome measurement	SPECC1L OLFM3	8.27e-03	112	36	2	EFO_0007753

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLPGMKRIGASTKSK	TTC21B	591	Q7Z4L5
LTSVGNTGMKKVPKK	EP400	336	Q96L91
FGKSVQKKTMVLGTP	CDHR1	576	Q96JP9
GKSTTIKMITGDTKP	ABCA9	1331	Q8IUA7
MKKASRSVGSVPKVS	SPECC1L	1	Q69YQ0
GVSGSLKGVPKKSKM	BRPF3	436	Q9ULD4
TGTKMVLTTKVGSPA	BPTF	2086	Q12830
PPMKSLSSTSAGGKK	BCOR	1291	Q6W2J9
ILVSGMKTGSSKLKA	NUP210	206	Q8TEM1
TTIGGLNKKPMSLAS	MAP4	731	P27816
KKGSKGPVIKITEMS	KRT80	426	Q6KB66
STLGMKIVIKPSSLS	INTS2	501	Q9H0H0
SSLPLTSVGNTGMKK	EP400P1	321	Q6ZTU2
TSVGNTGMKKVPKKL	EP400P1	326	Q6ZTU2
DMKPGSTLKITGSIA	LGALS2	11	P05162
FKLSSPRGGMKKKTT	RPL7	211	P18124
PMSSLIAGKGKAILS	GPR75	191	O95800
PSSHKLKVISKSMGT	FZD6	546	O60353
MPEVSSKGATISKKG	H2BC1	1	Q96A08
KGKKPEVSMLATTGL	IGSF10	1586	Q6WRI0
TKSGSVTLSQKPKML	CENPJ	446	Q9HC77
MSSKNIKKSGGTPTS	GPATCH2	351	Q9NW75
SVPQTSTSKGKVMLK	RNF103	176	O00237
TGIGPKSITKKMIEG	CAMSAP2	1426	Q08AD1
KLTCGKLMKITGPVT	OLFM3	216	Q96PB7
KLMKITGPVTVKTSG	OLFM3	221	Q96PB7
MKIIKGSSGTPKLSY	CMTR1	721	Q8N1G2
GSSSTKMKPQGKPSS	MED1	1166	Q15648
LSTAPGMKFKTKTLT	PLA2G4D	51	Q86XP0
TTILTPKTIIKSAMG	OR52H1	141	Q8NGJ2
VMGKGDVLKTSPKTS	FER1L6	206	Q2WGJ9
MIPKLKTRTQKTGGA	SRP19	111	P09132
SKSMTVKVSGKRIPV	PSG8	406	Q9UQ74
STLGPKGMDKILLSS	CCT2	41	P78371
LPRSKTVMKTGSAGL	SPAST	246	Q9UBP0
MSLKGTTVTPDKRKG	ADRM1	31	Q16186
KGSKGDTSMLKPTLM	ACSL3	366	O95573
TGSQSKSKMKRGTPT	SUPT20H	761	Q8NEM7
AKIMRKSGNKVSTPG	WDFY4	521	Q6ZS81
SSGFMKTAVLGPTLK	ZNF518A	411	Q6AHZ1
GVSSLGCKSTPKMTK	ZNF354B	81	Q96LW1
VMKKGKSTGSLLTPT	ARHGAP21	1736	Q5T5U3