Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	4.66e-07	5	73	3	GO:0030156
GeneOntologyMolecularFunction	NADPH-hemoprotein reductase activity	POR CYB5R4	1.31e-04	5	73	2	GO:0003958
GeneOntologyMolecularFunction	cytochrome-b5 reductase activity, acting on NAD(P)H	POR CYB5R4	2.74e-04	7	73	2	GO:0004128
GeneOntologyBiologicalProcess	ventral spinal cord development	SOX1 CACNA1A OLIG3 GLI3 OLIG2	1.75e-06	57	73	5	GO:0021517
GeneOntologyBiologicalProcess	cell differentiation in spinal cord	SOX1 CACNA1A OLIG3 GLI3 OLIG2	2.89e-06	63	73	5	GO:0021515
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	RIMBP3 CACNA1A RIMBP3C RIMBP3B	7.81e-06	36	73	4	GO:0007274
GeneOntologyBiologicalProcess	spinal cord motor neuron differentiation	CACNA1A OLIG3 GLI3 OLIG2	1.32e-05	41	73	4	GO:0021522
GeneOntologyBiologicalProcess	neuron fate specification	SOX1 OLIG3 GLI3 FOXA2	1.46e-05	42	73	4	GO:0048665
GeneOntologyBiologicalProcess	neuron fate commitment	SOX1 OLIG3 GLI3 FOXA2 OLIG2	1.77e-05	91	73	5	GO:0048663
GeneOntologyBiologicalProcess	spinal cord development	SOX1 CACNA1A OLIG3 GLI3 OLIG2	6.45e-05	119	73	5	GO:0021510
GeneOntologyBiologicalProcess	cell fate specification	SOX1 OLIG3 GLI3 FOXA2 OLIG2	7.55e-05	123	73	5	GO:0001708
GeneOntologyBiologicalProcess	cell fate specification involved in pattern specification	SOX1 GLI3	3.41e-04	8	73	2	GO:0060573
GeneOntologyBiologicalProcess	SRP-dependent cotranslational protein targeting to membrane, translocation	SEC61A2 SEC61A1	3.41e-04	8	73	2	GO:0006616
GeneOntologyBiologicalProcess	post-translational protein targeting to membrane, translocation	SEC61A2 SEC61A1	3.41e-04	8	73	2	GO:0031204
GeneOntologyBiologicalProcess	ventral spinal cord interneuron specification	SOX1 GLI3	3.41e-04	8	73	2	GO:0021521
GeneOntologyBiologicalProcess	smoothened signaling pathway	KCTD6 IFT57 GLI3 POR FOXA2	4.02e-04	176	73	5	GO:0007224
GeneOntologyCellularComponent	Sec61 translocon complex	SEC61A2 SEC61A1	1.26e-04	5	75	2	GO:0005784
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	1.36e-04	28	75	3	GO:0002177
GeneOntologyCellularComponent	translocon complex	SEC61A2 SEC61A1	1.89e-04	6	75	2	GO:0071256
HumanPheno	Proximal tibial and fibular fusion	GLI3 POR	1.05e-05	2	17	2	HP:0005892
HumanPheno	Synostosis involving the tibia	GLI3 POR	3.14e-05	3	17	2	HP:0005929
HumanPheno	Synostosis involving the fibula	GLI3 POR	3.14e-05	3	17	2	HP:0005928
MousePheno	fused cornea and lens	AGAP5 AGAP7P AGAP4 AGAP6	3.06e-06	24	60	4	MP:0001307
MousePheno	abnormal lens development	SOX1 AGAP5 AGAP7P AGAP4 AGAP6	2.04e-05	78	60	5	MP:0005545
MousePheno	abnormal eye development	SOX1 AGAP5 GLI3 BARHL2 AGAP7P MORC2 FOXA2 AGAP4 AGAP6 MSI2	3.47e-05	482	60	10	MP:0001286
MousePheno	abnormal tooth morphology	AMBN AGAP5 GLI3 AGAP7P MORC2 FOXA2 AGAP4 AGAP6	6.00e-05	318	60	8	MP:0002100
MousePheno	abnormal dental arch morphology	AMBN AGAP5 GLI3 AGAP7P MORC2 FOXA2 AGAP4 AGAP6	6.14e-05	319	60	8	MP:0030254
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	6.94e-05	19	60	3	MP:0009377
MousePheno	abnormal jaw morphology	AMBN AGAP5 FBN2 IFT57 GLI3 AGAP7P MORC2 FOXA2 AGAP4 AGAP6	7.70e-05	530	60	10	MP:0000454
MousePheno	abnormal reflex	CACNA1A SEC61A2 AGAP5 FBN2 FRMD7 SPRYD3 RBM6 NAV2 BBS2 AGAP7P MORC2 FOXA2 OLIG2 AGAP4 AGAP6 MSI2	7.80e-05	1294	60	16	MP:0001961
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	9.46e-05	21	60	3	MP:0008893
MousePheno	abnormal sensory capabilities/reflexes/nociception	CACNA1A SEC61A2 AGAP5 FBN2 FRMD7 SPRYD3 RBM6 NAV2 BBS2 AGAP7P MORC2 FOXA2 OLIG2 METTL15 AGAP4 AGAP6 MSI2	1.16e-04	1486	60	17	MP:0002067
MousePheno	abnormal viscerocranium morphology	AMBN AGAP5 FBN2 IFT57 GLI3 AGAP7P MORC2 FOXA2 AGAP4 AGAP6	1.94e-04	593	60	10	MP:0005274
Domain	ArfGap	AGAP5 AGAP7P AGAP4 AGAP6	5.00e-06	29	74	4	SM00105
Domain	ArfGap	AGAP5 AGAP7P AGAP4 AGAP6	5.00e-06	29	74	4	PF01412
Domain	ARFGAP	AGAP5 AGAP7P AGAP4 AGAP6	5.00e-06	29	74	4	PS50115
Domain	ArfGAP	AGAP5 AGAP7P AGAP4 AGAP6	5.00e-06	29	74	4	IPR001164
Domain	Plug_translocon	SEC61A2 SEC61A1	1.55e-05	2	74	2	PF10559
Domain	SecY_su_dom	SEC61A2 SEC61A1	1.55e-05	2	74	2	IPR023201
Domain	SecY	SEC61A2 SEC61A1	1.55e-05	2	74	2	PF00344
Domain	SECY_1	SEC61A2 SEC61A1	1.55e-05	2	74	2	PS00755
Domain	SECY_2	SEC61A2 SEC61A1	1.55e-05	2	74	2	PS00756
Domain	-	SEC61A2 SEC61A1	1.55e-05	2	74	2	1.10.3370.10
Domain	Translocon_Sec61/SecY_plug_dom	SEC61A2 SEC61A1	1.55e-05	2	74	2	IPR019561
Domain	SecY_CS	SEC61A2 SEC61A1	1.55e-05	2	74	2	IPR030659
Domain	SecY/SEC61-alpha	SEC61A2 SEC61A1	1.55e-05	2	74	2	IPR002208
Domain	ANK	ANKRD13B AGAP5 ASPG AGAP7P AGAP4 AGAP6	4.79e-04	251	74	6	SM00248
Domain	ANK_REPEAT	ANKRD13B AGAP5 ASPG AGAP7P AGAP4 AGAP6	5.00e-04	253	74	6	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD13B AGAP5 ASPG AGAP7P AGAP4 AGAP6	5.10e-04	254	74	6	IPR020683
Domain	ANK_REP_REGION	ANKRD13B AGAP5 ASPG AGAP7P AGAP4 AGAP6	5.10e-04	254	74	6	PS50297
Domain	Ankyrin_rpt	ANKRD13B AGAP5 ASPG AGAP7P AGAP4 AGAP6	6.00e-04	262	74	6	IPR002110
Domain	PH	AGAP5 IRS4 AGAP7P FERMT2 AGAP4 AGAP6	8.18e-04	278	74	6	SM00233
Domain	PH_DOMAIN	AGAP5 IRS4 AGAP7P FERMT2 AGAP4 AGAP6	8.33e-04	279	74	6	PS50003
Domain	PH_domain	AGAP5 IRS4 AGAP7P FERMT2 AGAP4 AGAP6	8.49e-04	280	74	6	IPR001849
Domain	OxRdtase_FAD/NAD-bd	POR CYB5R4	9.96e-04	12	74	2	IPR001433
Domain	NAD_binding_1	POR CYB5R4	9.96e-04	12	74	2	PF00175
Domain	PH_dom-like	AGAP5 IRS4 FRMD7 AGAP7P FERMT2 AGAP4 AGAP6	1.48e-03	426	74	7	IPR011993
Domain	Ank_2	ANKRD13B AGAP5 ASPG AGAP4 AGAP6	1.63e-03	215	74	5	PF12796
Domain	Fd_Rdtase_FAD-bd	POR CYB5R4	2.54e-03	19	74	2	IPR017927
Domain	FAD_FR	POR CYB5R4	2.54e-03	19	74	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	POR CYB5R4	2.54e-03	19	74	2	IPR017938
Domain	-	ANKRD13B AGAP5 ASPG AGAP4 AGAP6	3.03e-03	248	74	5	1.25.40.20
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	3.67e-03	78	74	3	PF14604
Domain	FG-GAP	BBS2 ITGA9	4.04e-03	24	74	2	PF01839
Domain	FG-GAP	BBS2 ITGA9	4.04e-03	24	74	2	IPR013517
Domain	-	AGAP5 IRS4 FRMD7 FERMT2 AGAP4 AGAP6	4.53e-03	391	74	6	2.30.29.30
Domain	SH3_2	RIMBP3 RIMBP3C RIMBP3B	4.83e-03	86	74	3	IPR011511
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP7P AGAP4 AGAP6	2.77e-09	9	77	4	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP7P AGAP4 AGAP6	4.62e-09	10	77	4	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP7P AGAP4 AGAP6	7.24e-09	11	77	4	15381706
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 AGAP7P AGAP4 AGAP6	1.56e-08	13	77	4	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP7P AGAP4 AGAP6	2.19e-08	14	77	4	22453919
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	4.17e-08	4	77	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.04e-07	5	77	3	17855024
Pubmed	Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.	SOX1 OLIG3 FOXA2 OLIG2	4.37e-07	28	77	4	24995796
Pubmed	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.	IFT57 GLI3 FOXA2 OLIG2	5.06e-07	29	77	4	21209331
Pubmed	Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.	SOX1 GLI3 FOXA2 OLIG2	7.62e-07	32	77	4	19286674
Pubmed	Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.	SOX1 GLI3 OLIG2	8.68e-07	9	77	3	23249739
Pubmed	Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.	GLI3 FOXA2 OLIG2	8.68e-07	9	77	3	37943875
Pubmed	The loss of Hh responsiveness by a non-ciliary Gli2 variant.	GLI3 FOXA2 OLIG2	8.68e-07	9	77	3	25834022
Pubmed	Suppressor of Fused Chaperones Gli Proteins To Generate Transcriptional Responses to Sonic Hedgehog Signaling.	GLI3 FOXA2 OLIG2	1.24e-06	10	77	3	27849569
Pubmed	Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia.	GLI3 FOXA2 OLIG2	1.70e-06	11	77	3	30791390
Pubmed	IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport.	GLI3 FOXA2 OLIG2	2.26e-06	12	77	3	22595669
Pubmed	Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.	GLI3 FOXA2 OLIG2	2.26e-06	12	77	3	28891097
Pubmed	A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.	GLI3 FOXA2 OLIG2	2.26e-06	12	77	3	21062862
Pubmed	Dual function of suppressor of fused in Hh pathway activation and mouse spinal cord patterning.	GLI3 FOXA2 OLIG2	2.26e-06	12	77	3	22182519
Pubmed	Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.	GLI3 FOXA2 OLIG2	2.26e-06	12	77	3	28412462
Pubmed	The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.	GLI3 FOXA2 OLIG2	2.26e-06	12	77	3	32758357
Pubmed	T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.	GLI3 FOXA2 OLIG2	2.94e-06	13	77	3	25760946
Pubmed	Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.	GLI3 FOXA2 OLIG2	2.94e-06	13	77	3	26965371
Pubmed	The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.	GLI3 FOXA2 OLIG2	2.94e-06	13	77	3	19592253
Pubmed	Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.	GLI3 FOXA2 OLIG2	3.73e-06	14	77	3	20463034
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	3.73e-06	14	77	3	17662146
Pubmed	Cytoneme signaling provides essential contributions to mammalian tissue patterning.	OLIG3 FOXA2 OLIG2	3.73e-06	14	77	3	38171360
Pubmed	Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro.	SOX1 GLI3 OLIG2	3.73e-06	14	77	3	21766338
Pubmed	Complex interactions between genes controlling trafficking in primary cilia.	GLI3 FOXA2 OLIG2	3.73e-06	14	77	3	21552265
Pubmed	Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.	GLI3 FOXA2 OLIG2	4.66e-06	15	77	3	34486668
Pubmed	A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning.	GLI3 FOXA2 OLIG2	4.66e-06	15	77	3	25458012
Pubmed	THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.	GLI3 FOXA2 OLIG2	4.66e-06	15	77	3	18327258
Pubmed	Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.	SEC61A2 SEC61A1	4.84e-06	2	77	2	18480044
Pubmed	A role for SOX1 in neural determination.	SOX1 FOXA2	4.84e-06	2	77	2	9550729
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX1 HIVEP3 OLIG3 NKX2-4 GLI3 BARHL2 ONECUT3 PBX2 FOXA2 OLIG2 ATF6B	5.02e-06	908	77	11	19274049
Pubmed	The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling.	GLI3 FOXA2 OLIG2	5.72e-06	16	77	3	31964774
Pubmed	Hedgehog signalling in the mouse requires intraflagellar transport proteins.	GLI3 FOXA2 OLIG2	5.72e-06	16	77	3	14603322
Pubmed	Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh.	SOX1 GLI3 OLIG2	6.94e-06	17	77	3	23444355
Pubmed	Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c.	GLI3 FOXA2 OLIG2	6.94e-06	17	77	3	34752747
Pubmed	Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.	IFT57 GLI3 FOXA2	6.94e-06	17	77	3	23955340
Pubmed	Geminin is required for Hox gene regulation to pattern the developing limb.	SOX1 GLI3 FOXA2	6.94e-06	17	77	3	32450229
Pubmed	The graded response to Sonic Hedgehog depends on cilia architecture.	GLI3 FOXA2 OLIG2	8.31e-06	18	77	3	17488627
Pubmed	A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.	GLI3 FOXA2 OLIG2	8.31e-06	18	77	3	12435628
Pubmed	Disrupted dorsal neural tube BMP signaling in the cilia mutant Arl13b hnn stems from abnormal Shh signaling.	OLIG3 GLI3 OLIG2	9.86e-06	19	77	3	21539826
Pubmed	Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.	GLI3 FOXA2 OLIG2	9.86e-06	19	77	3	22698544
Pubmed	Gas1 extends the range of Hedgehog action by facilitating its signaling.	GLI3 FOXA2 OLIG2	9.86e-06	19	77	3	17504940
Pubmed	Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord.	GLI3 FOXA2 OLIG2	9.86e-06	19	77	3	17507410
Pubmed	Cilia and Hedgehog responsiveness in the mouse.	GLI3 FOXA2 OLIG2	9.86e-06	19	77	3	16061793
Pubmed	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.	GLI3 FOXA2 OLIG2	9.86e-06	19	77	3	23332756
Pubmed	Cell Cycle-Related Kinase (CCRK) regulates ciliogenesis and Hedgehog signaling in mice.	GLI3 FOXA2 OLIG2	9.86e-06	19	77	3	28817564
Pubmed	Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.	GLI3 FOXA2 OLIG2	1.16e-05	20	77	3	21045211
Pubmed	Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.	GLI3 FOXA2 OLIG2	1.16e-05	20	77	3	32702291
Pubmed	Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.	GLI3 FOXA2 OLIG2	1.35e-05	21	77	3	22007132
Pubmed	Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.	GLI3 FOXA2 OLIG2	1.35e-05	21	77	3	28688895
Pubmed	Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development.	GLI3 FOXA2 OLIG2	1.35e-05	21	77	3	23618354
Pubmed	Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging.	SOX1 FOXA2	1.45e-05	3	77	2	39251590
Pubmed	Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.	GLI3 FOXA2 OLIG2	1.56e-05	22	77	3	19223390
Pubmed	Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.	GLI3 FOXA2 OLIG2	1.56e-05	22	77	3	20159594
Pubmed	ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.	GLI3 FOXA2 OLIG2	1.56e-05	22	77	3	25294941
Pubmed	Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.	GLI3 FOXA2 OLIG2	1.56e-05	22	77	3	12435629
Pubmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.	GLI3 FOXA2 OLIG2	1.79e-05	23	77	3	30814516
Pubmed	Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos.	SOX1 FOXA2 OLIG2	2.04e-05	24	77	3	31235634
Pubmed	Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner.	GLI3 FOXA2 OLIG2	2.32e-05	25	77	3	18927156
Pubmed	Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice.	SOX1 OLIG3 OLIG2	2.32e-05	25	77	3	19357274
Pubmed	A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors.	GLI3 OLIG2	2.89e-05	4	77	2	30782847
Pubmed	The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.	SEC61A2 SEC61A1	2.89e-05	4	77	2	10212142
Pubmed	The small GTPase RSG1 controls a final step in primary cilia initiation.	GLI3 FOXA2 OLIG2	3.28e-05	28	77	3	29038301
Pubmed	Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord.	GLI3 FOXA2 OLIG2	4.06e-05	30	77	3	23482494
Pubmed	Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.	GLI3 FOXA2 OLIG2	4.06e-05	30	77	3	24302887
Pubmed	A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.	GLI3 FOXA2	4.82e-05	5	77	2	9118802
Pubmed	Oct4 is required ~E7.5 for proliferation in the primitive streak.	SOX1 FOXA2	4.82e-05	5	77	2	24244203
Pubmed	Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice.	SOX1 MSI2	4.82e-05	5	77	2	12923295
Pubmed	Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.	GLI3 FOXA2	4.82e-05	5	77	2	9216996
Pubmed	Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.	SEC61A2 SEC61A1	4.82e-05	5	77	2	9565615
Pubmed	Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.	OLIG3 OLIG2	4.82e-05	5	77	2	11091082
Pubmed	Arx together with FoxA2, regulates Shh floor plate expression.	FOXA2 OLIG2	4.82e-05	5	77	2	24968361
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	SOX1 FOXA2 OLIG2	5.94e-05	34	77	3	18539113
Pubmed	FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.	SOX1 FOXA2 OLIG2	5.94e-05	34	77	3	18590716
Pubmed	Human transcription factor protein interaction networks.	CUL2 IRS4 FBN2 NKX2-4 ATAD3A GLI3 PSMB1 RBM6 MTR MORC2 PBX2 MSI2	6.86e-05	1429	77	12	35140242
Pubmed	Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube.	OLIG3 OLIG2	7.22e-05	6	77	2	11960707
Pubmed	Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress.	SEC61A2 SEC61A1	7.22e-05	6	77	2	16705175
Pubmed	Lineage specificity of primary cilia in the mouse embryo.	FOXA2 OLIG2	7.22e-05	6	77	2	25599390
Pubmed	Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo.	FOXA2 OLIG2	1.01e-04	7	77	2	28926609
Pubmed	Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.	OLIG3 OLIG2	1.01e-04	7	77	2	11507077
Pubmed	Expression of the Olig gene family in the developing mouse inner ear.	OLIG3 OLIG2	1.01e-04	7	77	2	25778822
Pubmed	Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.	FOXA2 OLIG2	1.01e-04	7	77	2	29571613
Pubmed	Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.	GLI3 FOXA2	1.01e-04	7	77	2	9731531
Pubmed	Two distinct sources for a population of maturing axial progenitors.	SOX1 FOXA2	1.01e-04	7	77	2	17611225
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	AGAP5 ASPG AGAP4 AGAP6	1.32e-04	116	77	4	30652415
Pubmed	Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.	GLI3 FOXA2	1.34e-04	8	77	2	30301781
Pubmed	Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.	GLI3 OLIG2	1.34e-04	8	77	2	22265416
Pubmed	TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.	FOXA2 OLIG2	1.34e-04	8	77	2	36669111
Pubmed	Sonic hedgehog is essential to foregut development.	GLI3 FOXA2	1.34e-04	8	77	2	9731532
Pubmed	A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors.	BARHL2 FOXA2	1.34e-04	8	77	2	18701067
Pubmed	Bone morphology is regulated modularly by global and regional genetic programs.	GLI3 PBX2	1.72e-04	9	77	2	31221640
Pubmed	Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.	FOXA2 OLIG2	1.72e-04	9	77	2	29389974
Pubmed	Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.	NKX2-4 FOXA2	1.72e-04	9	77	2	10818213
Pubmed	The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.	FOXA2 OLIG2	1.72e-04	9	77	2	16647304
Pubmed	Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.	FOXA2 OLIG2	1.72e-04	9	77	2	25840610
Pubmed	Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation.	SOX1 OLIG2	1.72e-04	9	77	2	15652703
Cytoband	22q11.21	RIMBP3 RIMBP3C MICAL3 RIMBP3B	3.82e-05	111	77	4	22q11.21
GeneFamily	ArfGAPs	AGAP5 AGAP7P AGAP4 AGAP6	2.53e-06	33	53	4	395
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP4 AGAP6	1.57e-05	17	53	3	1291
GeneFamily	Ankyrin repeat domain containing	ANKRD13B AGAP5 ASPG AGAP7P AGAP4 AGAP6	7.33e-05	242	53	6	403
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 AGAP7P FERMT2 AGAP4 AGAP6	3.37e-04	206	53	5	682
Coexpression	THEODOROU_MAMMARY_TUMORIGENESIS	AGAP5 AGAP7P AGAP4 AGAP6	4.01e-06	37	76	4	MM1121
Coexpression	BENPORATH_SUZ12_TARGETS	SOX1 RIMBP3 CACNA1A ADCY4 IRS4 FBN2 BARHL2 NAV2 RIMBP3C EGFLAM FOXA2 RIMBP3B OLIG2	7.99e-06	1035	76	13	M9898
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN	AGAP5 AGAP7P AGAP4 AGAP6	8.11e-06	44	76	4	MM485
Coexpression	BENPORATH_ES_WITH_H3K27ME3	RIMBP3 C1QL1 CACNA1A OLIG3 ADCY4 FBN2 BARHL2 NAV2 RIMBP3C EGFLAM FOXA2 RIMBP3B OLIG2	1.76e-05	1115	76	13	M10371
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	HIVEP3 GLI3 NAV2 MICAL3 OLIG2	2.41e-06	125	76	5	6cd741dd1c7ee6b16437cca7c15c99b5c95603fc
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP7P AGAP4 AGAP6	5.69e-09	10	69	4	DOID:1969 (implicated_via_orthology)
Disease	blood osmolality measurement	XXYLT1 NAV2 CYB5R4	3.44e-04	58	69	3	EFO_0007967
Disease	hepcidin:transferrin saturation ratio	KCTD6 EML6	5.55e-04	15	69	2	EFO_0007902
Disease	alcoholic liver disease	FBN2 GLI3 MTR	9.50e-04	82	69	3	EFO_0008573
Disease	necrotizing enterocolitis	IDO2 ADCY4	1.82e-03	27	69	2	EFO_0003928
Disease	type 2 diabetes mellitus (implicated_via_orthology)	IRS4 MTR CYB5R4	1.93e-03	105	69	3	DOID:9352 (implicated_via_orthology)
Disease	seasonal gut microbiome measurement	GLI3 NAV2 CYB5R4	2.32e-03	112	69	3	EFO_0007753

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPVHYAGDFDGMSMD	AFDN	1371	P55196
MARFGDEMPARYGGG	CACNA1A	1	O00555
IYEAGAGDRMAGAPM	AGAP4	31	Q96P64
MDGGSLRASPAAMDG	LINC00479	1	Q96M42
GPCMLGKGYHEMGRA	SLC4A9	271	Q96Q91
VDDYGARTGKSPGMM	EGFLAM	941	Q63HQ2
AGGREDPMAYGAMFP	AMBN	266	Q9NP70
MTGLCGYSAPDMRGL	APOF	1	Q13790
YAIMTGGDVAPMGRE	ATAD3A	421	Q9NVI7
EREGYGPLGMTGISM	ABHD18	186	Q0P651
GGPEGHYEMLGTCRM	C1QL1	16	O75973
YAMLPLGMRDAAVAG	ADCY4	131	Q8NFM4
TYEAGARDRMAGAPM	AGAP6	31	Q5VW22
RGLPYTMDAFMLGMG	MSI2	201	Q96DH6
ALRAGDVVMVYGPMD	RIMBP3B	1596	A6NNM3
ALRAGDVVMVYGPMD	RIMBP3C	1596	A6NJZ7
PVLGDGMLGDLMELY	INTS7	461	Q9NVH2
ALFEAPRGYSMMGGQ	ANKRD13B	481	Q86YJ7
PRGYSMMGGQREAAT	ANKRD13B	486	Q86YJ7
DNLGGGQMYSPREMR	PBX2	386	P40425
PMGTGIARGFLAAMD	MICAL3	406	Q7RTP6
GNMGELPAYTDGMRG	NKX2-4	116	Q9H2Z4
GTVFAMDPRNGYMEP	GLI3	106	P10071
DAHRYGMRGMSADPE	POR	101	P16435
GMRGMSADPEEYDLA	POR	106	P16435
MDGVYGSGEVPRPQM	GRXCR2	61	A6NFK2
TDYAAGMAMAGAGVI	ASPG	306	Q86U10
MYGIRPHPASDGEGM	FRMD7	186	Q6ZUT3
DNPAMPAGLMYEGVS	IDO2	256	Q6ZQW0
LKDEFYGLAGMPGVM	HARBI1	131	Q96MB7
YGLAGMPGVMGVVDC	HARBI1	136	Q96MB7
KMEHAGAMAGGYRSP	GPR119	201	Q8TDV5
MDGGRYPDMPTAADV	METTL15	196	A6NJ78
LAMDGLREVMPYAHG	OLIG3	101	Q7RTU3
MMGLGASDFEFGVDP	PIPSL	681	A2A3N6
GFMLCFLDDGAGMDP	MORC2	61	Q9Y6X9
MDGNGYPDVTVGAFM	ITGA9	436	Q13797
ERGPGAAYHMFVVME	IFT57	31	Q9NWB7
GYLPGTAEMRGNLMD	BBS2	316	Q9BXC9
LVRHGYMIVGDPMGG	DNAH3	1701	Q8TD57
GYGGVDMNEPLMEIG	CUL2	126	Q13617
DFAGGMDTDMAGQLP	FAM131A	201	Q6UXB0
IYEAGAEDRMAGAPM	AGAP7P	31	Q5VUJ5
GMMNGDFRPLGEART	BARHL2	26	Q9NY43
TRYPDSMLGAMFGGD	KCTD6	31	Q8NC69
DGMVYALGGMGPDTA	KLHDC8B	126	Q8IXV7
YSPDGEMVAIGMKNG	EML6	1736	Q6ZMW3
EEYRRLCMDGLPMGG	FBN2	411	P35556
MALDGIRMPDGCYAD	FERMT2	1	Q96AC1
PIDDAYMGMCLERAG	B3GNT6	306	Q6ZMB0
YMGMCLERAGLAPSG	B3GNT6	311	Q6ZMB0
AAAGAMAGVMGAYLG	SLC25A35	106	Q3KQZ1
MFRQYSGDDGRMDMP	S100A7L2	16	Q5SY68
ARAGAVLMGMEGPFF	IZUMO2	51	Q6UXV1
AMYSAPGRDLGMEPH	PSMB1	6	P20618
AMGMACEAPGLGGTY	ONECUT3	91	O60422
GKEDQEGSGGDYMPM	IRS4	476	O14654
ESDYMFMAPGAGAIP	IRS4	776	O14654
QAAGAMGGLAPYANM	FOXA2	116	Q9Y261
PPMDYRGGDGTSMDY	RBM6	131	P78332
DFVRDFMGAMYGDPT	QTRT1	371	Q9BXR0
MYGDPAEMGAGICLL	SEC61A2	136	Q9H9S3
MNGFTPDEMSRGGDA	SAP30	1	O75446
ALRAGDVVMVYGPMD	RIMBP3	1596	Q9UFD9
GMDMGIVNAGNLPVY	MTR	606	Q99707
LEGISMDAPGYMSDG	NAV2	876	Q8IVL1
IAMDGLREVMPYAHG	OLIG2	126	Q13516
DMGMYFAAGLLAGGP	OR7A17	196	O14581
REMISMYLPAGEGGD	SOX1	341	O00570
MEYHPGGEDELMRAA	CYB5R4	86	Q7L1T6
MFEPRGHRDMYGAVL	L3HYPDH	66	Q96EM0
IYEAGAGDRMAGAPM	AGAP5	31	A6NIR3
SGRGAPGDYEEMMQI	ATF6B	631	Q99941
GYMDPRERDMRMGGG	SFPQ	601	P23246
MEGGMAAYPVATRES	nan	1	Q9BTK2
KGDIMGCGIMFPRDY	SPRYD3	321	Q8NCJ5
MYGDPSEMGAGICLL	SEC61A1	136	P61619
IKAGLASGMGGEMYP	HIVEP3	246	Q5T1R4
RAAFSEDGALMDGGM	TMEM208	76	Q9BTX3
GYMGEMEVQGPTRES	ZNF862	86	O60290
GGGAGPVDYHLLMMF	XXYLT1	91	Q8NBI6
GEVDGGMAMLRPDSF	WFIKKN2	531	Q8TEU8
AGMVYMAGLVFAVGG	KLHL2	346	O95198