Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesshepatocyte differentiation

FRZB MESP1 PCK2

1.21e-0516593GO:0070365
GeneOntologyBiologicalProcessregulation of hepatocyte differentiation

FRZB MESP1

4.81e-054592GO:0070366
GeneOntologyCellularComponentMOZ/MORF histone acetyltransferase complex

KAT6A KAT6B

1.74e-047612GO:0070776
GeneOntologyCellularComponentH3 histone acetyltransferase complex

KAT6A KAT6B

2.32e-048612GO:0070775
DomainMOZ_SAS

KAT6A KAT6B

1.01e-045602PF01853
DomainHAT_MYST-type

KAT6A KAT6B

1.01e-045602IPR002717
DomainMYST_HAT

KAT6A KAT6B

1.01e-045602PS51726
DomainH15

KAT6A KAT6B

7.74e-0413602SM00526
DomainH15

KAT6A KAT6B

7.74e-0413602PS51504
DomainHistone_H1/H5_H15

KAT6A KAT6B

9.01e-0414602IPR005818
DomainZnf_FYVE_PHD

PHF12 KAT6A KAT6B FGD6

1.28e-03147604IPR011011
DomainHEAT_REPEAT

HEATR6 PSME4 INTS4

1.48e-0370603PS50077
DomainALDEHYDE_DEHYDR_GLU

ALDH16A1 ALDH6A1

1.50e-0318602PS00687
DomainALDEHYDE_DEHYDR_CYS

ALDH16A1 ALDH6A1

1.50e-0318602PS00070
DomainAld_DH_C

ALDH16A1 ALDH6A1

1.68e-0319602IPR016163
DomainAld_DH_N

ALDH16A1 ALDH6A1

1.68e-0319602IPR016162
DomainAld_DH/histidinol_DH

ALDH16A1 ALDH6A1

1.68e-0319602IPR016161
Domain-

ALDH16A1 ALDH6A1

1.68e-03196023.40.605.10
DomainAldedh

ALDH16A1 ALDH6A1

1.68e-0319602PF00171
DomainAldehyde_DH_dom

ALDH16A1 ALDH6A1

1.68e-0319602IPR015590
Domain-

ALDH16A1 ALDH6A1

1.68e-03196023.40.309.10
DomainPHD

PHF12 KAT6A KAT6B

1.81e-0375603PF00628
DomainZnf_PHD-finger

PHF12 KAT6A KAT6B

2.10e-0379603IPR019787
DomainPHD

PHF12 KAT6A KAT6B

2.94e-0389603SM00249
DomainZnf_PHD

PHF12 KAT6A KAT6B

3.13e-0391603IPR001965
DomainZF_PHD_2

PHF12 KAT6A KAT6B

3.54e-0395603PS50016
DomainZF_PHD_1

PHF12 KAT6A KAT6B

3.64e-0396603PS01359
Domain-

KAT6A KAT6B

7.32e-03406023.40.630.30
DomainAcyl_CoA_acyltransferase

KAT6A KAT6B

9.19e-0345602IPR016181
Pubmed

High-throughput microarray detection of olfactory receptor gene expression in the mouse.

OR2M7 OR2M5 OR2M3

2.16e-08462315377787
Pubmed

Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease.

KAT6A KAT6B

3.13e-06262227185879
Pubmed

ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.

KAT6A KAT6B

3.13e-06262239505971
Pubmed

The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.

KAT6A KAT6B

3.13e-06262224150941
Pubmed

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.

KAT6A KAT6B

9.37e-06362236754959
Pubmed

[The relationship between the expression of amplified in breast cancer 1、androgen receptor and tamoxifen resistance in breast cancer].

HEATR6 AR

9.37e-06362237246005
Pubmed

Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells.

GNAS AR

9.37e-06362218451148
Pubmed

Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin.

KAT6A KAT6B

9.37e-06362223063713
Pubmed

MicroRNAs are mediators of androgen action in prostate and muscle.

DICER1 AR

1.87e-05462221048966
Pubmed

The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.

KAT6A KAT6B

1.87e-05462217980166
Pubmed

Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF).

KAT6A KAT6B

1.87e-05462221880731
Pubmed

Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.

KAT6A KAT6B

3.12e-05562217182677
Pubmed

MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.

KAT6A KAT6B

3.12e-05562211965546
Pubmed

DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex.

EFCAB6 AR

3.12e-05562212612053
Pubmed

The Etv2-miR-130a Network Regulates Mesodermal Specification.

MESP1 DICER1

3.12e-05562226565905
Pubmed

The origin of the stapes and relationship to the otic capsule and oval window.

MESP1 DICER1

4.67e-05662222778034
Pubmed

Mesodermal expression of Moz is necessary for cardiac septum development.

FRZB KAT6A

6.53e-05762225912687
Pubmed

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

KAT6A KAT6B

6.53e-05762218794358
Pubmed

The mutational landscape of lethal castration-resistant prostate cancer.

ASH2L AR

8.69e-05862222722839
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

NPHP1 MPC2 SERINC1 CFAP20 CCDC154 FGD6 DICER1 NDUFS1 PCK2 PKN3

1.08e-041321621027173435
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

SLC6A8 COA6 CFAP20 PHF12 FRZB TSC1 MTX1 DICER1 ASH2L NDUFS1

1.12e-041327621032694731
Pubmed

Acetylation of HIV-1 integrase by p300 regulates viral integration.

KAT6A KAT6B

1.70e-041162216096645
Pubmed

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

DICER1 AR

2.41e-041362228363942
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

PDXDC1 CFAP20 GNAS ASH2L PKN3

2.43e-0431362538270169
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

POLR1D MPC2 MTX1 DICER1 NDUFS1 PCK2

3.12e-0451562631617661
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PSME4 SERINC1 PHF12 KAT6B CARNS1 DICER1

3.60e-0452962614621295
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

SLC18A1 CAPN6 DEF8 TMC4 NDUFS1

4.79e-0436362514691545
Pubmed

Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.

FRZB MESP1

5.24e-041962212490556
Pubmed

Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.

NPHP1 TSC1

5.82e-042062217251353
Pubmed

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.

NGEF MTCL1

7.06e-042262226494785
Pubmed

Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.

ALDH16A1 ALDH6A1

7.72e-042362218971422
Pubmed

Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.

MPC2 PCK2

8.41e-042462227754788
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

MTCL1 GNAS DICER1 NDUFS1

9.30e-0424262434011540
Pubmed

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

SLC18A1 AR

9.89e-042662219060910
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

PHF12 INTS4 ASH2L AR

1.35e-0326862433640491
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

FRZB KAT6A MTCL1 FGD6 NDUFS1 PCK2

1.42e-0368962636543142
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

PHF12 CAPN6 KEL FGD6

1.43e-0327262418187620
Pubmed

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.

MESP1 ASH2L

1.59e-033362224705356
Pubmed

Web-based, participant-driven studies yield novel genetic associations for common traits.

OR2M7 ALDH6A1

1.69e-033462220585627
Pubmed

Mitochondrial Raf1 Regulates Glutamine Catabolism.

GNAS PRMT7 DICER1 PCK2

1.76e-0328862438496616
Cytoband1q44

OR2M7 OR2M5 OR2M3

4.79e-041106331q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2M7 OR2M5 OR2M3

7.44e-04128633chr1q44
GeneFamilyPHD finger proteins

PHF12 KAT6A KAT6B ASH2L

4.13e-059039488
GeneFamilyZinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases

KAT6A KAT6B

5.34e-041639266
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT6A KAT6B

6.04e-0417392486
GeneFamilyAldehyde dehydrogenases

ALDH16A1 ALDH6A1

7.58e-0419392398
GeneFamilyOlfactory receptors, family 2

OR2M7 OR2M5 OR2M3

1.84e-03113393149
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

NGEF FGD6

8.91e-0366392722
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#5

IGSF10 SLF2 GSDMD FRZB CAPN6 KEL FGD6 PCK2

4.05e-06331608Facebase_RNAseq_e10.5_Mandibular Arch_1000_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3

NPHP1 IGSF10 MPC2 SLF2 REEP6 GSDMD FRZB CAPN6 KEL FGD6 PCK2

1.89e-058346011Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000

IGSF10 SLF2 REEP6 GSDMD FRZB CAPN6 ADGRB2 KEL ALDH6A1 FGD6 PCK2

8.06e-059786011Facebase_RNAseq_e10.5_Mandibular Arch_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#4

IGSF10 COA6 EFCAB6 GSDMD CAPN6 ADGRB2 KEL SAMSN1 FGD6

8.68e-05655609Facebase_RNAseq_e10.5_Maxillary Arch_2500_K4
DiseaseSex Cord-Stromal Tumor

GNAS DICER1

4.20e-062612C0206724
Diseaseleiomyoma (is_implicated_in)

KAT6B AR

6.27e-056612DOID:127 (is_implicated_in)
DiseasePituitary Adenoma

GNAS DICER1

1.50e-049612C0032000
Diseaselevel of Phosphatidylinositol (16:0_18:1) in blood serum

PDXDC1 TMC4

2.74e-0412612OBA_2045152
Disease1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement

PDXDC1 TMC4

3.76e-0414612EFO_0022085
Diseaseamyotrophic lateral sclerosis, age at onset

CCDC192 SLC18A1

4.34e-0415612EFO_0004847, MONDO_0004976
Diseasemetabolite measurement, diet measurement

PDXDC1 POLR1D PDXDC2P

4.35e-0471613EFO_0004725, EFO_0008111
DiseaseDiGeorge syndrome (implicated_via_orthology)

KAT6A DICER1

7.03e-0419612DOID:11198 (implicated_via_orthology)
Diseasehearing threshold measurement

SGSM1 MTCL1

1.53e-0328612EFO_0007618
Diseasebipolar disorder (is_implicated_in)

SLC18A1 KAT6B

1.65e-0329612DOID:3312 (is_implicated_in)
Diseaselongevity, healthspan, parental longevity

DEF8 FGD6

1.65e-0329612EFO_0004300, EFO_0007796, EFO_0009762
Diseaseintellectual disability (is_implicated_in)

SLC6A8 TSC1

1.76e-0330612DOID:1059 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
WMGKGHRMTPACPLL

ADGRB2

6

O60241
CTTMKGWPAATMTPA

GNAS

501

P84996
EMMWRICPALAVGCT

ALDH16A1

181

Q8IZ83
MVMRLHCGATPQWPE

B4GALNT3

906

Q6L9W6
WPQLPSGLSMMRCLH

GSDMD

256

P57764
MLLCLSPAWLMKVPA

CARNS1

1

A5YM72
QMSLMGKGEPPWLCR

LINC00469

21

Q8N7U9
PMKAALLTPMRAWTT

DNHD1

3411

Q96M86
VVLGPWCADKVAGMM

DICER1

311

Q9UPY3
KDMAPGKVVPMNCWG

CCDC154

606

A6NI56
MSSPQRRKAMPWALS

CST9

1

Q5W186
ECMTTRQRPGKMTWP

ASH2L

206

Q9UBL3
ARIPKCPWMEGGEMS

INTS4

921

Q96HW7
GSLRMPRPVAMWPCA

MTCL1

1301

Q9Y4B5
DPPLSRMPKGMWICQ

KAT6B

301

Q8WYB5
RMPKGMWICQVCRPK

KAT6B

306

Q8WYB5
PIMKWGLVCAGLADM

MPC2

46

O95563
IPLWMFPMAMVCGNT

ALDH6A1

191

Q02252
PFICTMPMRLDDGWN

CFAP20

116

Q9Y6A4
LAMMRPALPGWKVEC

PCK2

311

Q16822
MSPKICGLMTAFSWI

OR2M3

136

Q8NG83
MRPKICGLMTAFSWI

OR2M5

136

A3KFT3
MRPKICGLMTAFSWI

OR2M7

136

Q8NG81
WEMMSCPKGNPSSCI

MUC19

981

Q7Z5P9
KCDSMTMTPGPWLGL

PDXDC1

291

Q6P996
KCDSMTMTPGPWLGL

PDXDC2P

291

Q6P474
MFWTMMLNGPLPRAL

HEATR6

766

Q6AI08
ATAPGAMKMVAPWTR

LAPTM4B

86

Q86VI4
SPTCVKSEMGPWMDS

AR

516

P10275
ECCDPPLTRMPKGMW

KAT6A

291

Q92794
PLTRMPKGMWICQIC

KAT6A

296

Q92794
LFCMAPRPWNGALML

REEP6

121

Q96HR9
CRAEGTPSPEVMWIM

IGSF10

2261

Q6WRI0
MCKMAIIPDWLRSHP

EFCAB6

1

Q5THR3
MDPEGKIKCTMAPFW

PRMT7

286

Q9NVM4
MAILSLRAPGPWQAM

DEF8

1

Q6ZN54
GVPACSHMPMWSARL

CRIPAK

41

Q8N1N5
MMPVDVCPRDRGSQW

CCDC192

1

P0DO97
MCMLKGRASTAPPVW

ENPP6

411

Q6UWR7
MPKMSCWNLARGYPK

CAPN6

501

Q9Y6Q1
TLWSCKMIPLPGMSI

NPHP1

386

O15259
LTMWADPKLCARPMY

OR10G2

51

Q8NGC3
MAAWGRLVMNLLPPC

PKN3

451

Q6P5Z2
RVGKMAAPMELFCWS

MTX1

146

Q13505
PMGWMKCPLASTNKR

POLR1D

31

P0DPB5
PKVVAACAMPVMKGW

NDUFS1

86

P28331
IIDIICKTPMGMWTG

SAMSN1

191

Q9NSI8
IPWSRMPPCRTAMQT

NGEF

106

Q8N5V2
MLPPGEWMCHRCTVR

PHF12

91

Q96QT6
TAMPLGRWMCPNHIE

PHF12

306

Q96QT6
LPPVCVSRMRGMWRD

SHCBP1L

106

Q9BZQ2
IPMPVRRSWLMAKCA

SPATA31E1

781

Q6ZUB1
DIACMIGYRPCPWMK

SLC6A8

506

P48029
QCPVPVLKWLFRMMS

SLF2

801

Q8IX21
MAQPLCPPLSESWML

MESP1

1

Q9BRJ9
MGSVLGLCSMASWIP

SERINC1

1

Q9NRX5
GMAAPSMKERQVCWG

COA6

46

Q5JTJ3
PPQATLWSPSMVCGM

TSC1

341

Q92574
PLCKSLPWNMTKMPN

FRZB

41

Q92765
MACMTLLPTWLGGAP

TMC4

181

Q7Z404
APIWIPDTRATMCMI

FGD6

1216

Q6ZV73
PAWMMVPAGRSMLVV

SGSM1

446

Q2NKQ1
MKKRHREGCDMPGPW

nan

1

Q5BKY6
WRPLMCPFDVTMQKA

PSME4

196

Q14997
MVNPIAWSPESMEKC

UBR3

1631

Q6ZT12
MKSSSLPCWDLMPDI

VPS13B

3156

Q7Z7G8
PTLPIWMMQTMCSPK

SLC18A1

321

P54219
MPARPRWMKCVEETG

KEL

401

P23276