Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serotonin binding	HTR1D HTR1F	1.16e-04	13	25	2	GO:0051378
GeneOntologyMolecularFunction	amine binding	HTR1D HTR1F	3.11e-04	21	25	2	GO:0043176
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	HTR1D HTR1F	3.42e-04	22	25	2	GO:0004993
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	HTR1D HTR1F	1.20e-03	41	25	2	GO:0008227
GeneOntologyMolecularFunction	actinin binding	MICALL2 TRPC5	1.32e-03	43	25	2	GO:0042805
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting serotonin receptor signaling pathway	HTR1D HTR1F	2.95e-05	7	25	2	GO:0007198
GeneOntologyBiologicalProcess	phosphatidylserine exposure on apoptotic cell surface	XKR6 TRPC5	9.24e-05	12	25	2	GO:0070782
GeneOntologyCellularComponent	intermediate filament	KRTAP4-3 KRTAP4-16 KRTAP13-3 KRTAP10-11	1.68e-04	227	26	4	GO:0005882
GeneOntologyCellularComponent	keratin filament	KRTAP4-3 KRTAP4-16 KRTAP10-11	2.33e-04	97	26	3	GO:0045095
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRTAP4-3 KRTAP4-16 KRTAP13-3 KRTAP10-11	2.94e-04	263	26	4	GO:0045111
MousePheno	abnormal anal canal morphology	PCSK5 DACT1 CRIM1	4.29e-06	27	17	3	MP:0009053
MousePheno	absent anus	PCSK5 DACT1	1.39e-05	5	17	2	MP:0008999
MousePheno	abnormal anus morphology	PCSK5 DACT1	1.08e-04	13	17	2	MP:0005034
MousePheno	anal atresia	PCSK5 CRIM1	1.45e-04	15	17	2	MP:0003130
Domain	Peptidase_S8_Asp-AS	PCSK5 PCSK4	2.79e-05	6	26	2	IPR023827
Domain	PrprotnconvertsP	PCSK5 PCSK4	3.90e-05	7	26	2	IPR002884
Domain	P_proprotein	PCSK5 PCSK4	3.90e-05	7	26	2	PF01483
Domain	S8_pro-domain	PCSK5 PCSK4	3.90e-05	7	26	2	IPR032815
Domain	-	PCSK5 PCSK4	3.90e-05	7	26	2	3.30.70.850
Domain	S8_pro-domain	PCSK5 PCSK4	3.90e-05	7	26	2	PF16470
Domain	Peptidase_S8_His-AS	PCSK5 PCSK4	6.67e-05	9	26	2	IPR022398
Domain	5HT_rcpt	HTR1D HTR1F	6.67e-05	9	26	2	IPR002231
Domain	Peptidase_S8_Ser-AS	PCSK5 PCSK4	6.67e-05	9	26	2	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK5 PCSK4	8.33e-05	10	26	2	IPR015500
Domain	SUBTILASE_ASP	PCSK5 PCSK4	8.33e-05	10	26	2	PS00136
Domain	SUBTILASE_HIS	PCSK5 PCSK4	8.33e-05	10	26	2	PS00137
Domain	SUBTILASE_SER	PCSK5 PCSK4	8.33e-05	10	26	2	PS00138
Domain	Peptidase_S8	PCSK5 PCSK4	1.02e-04	11	26	2	PF00082
Domain	-	PCSK5 PCSK4	1.02e-04	11	26	2	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK5 PCSK4	1.02e-04	11	26	2	IPR000209
Domain	Propept_inh	PCSK5 PCSK4	2.50e-04	17	26	2	IPR009020
Domain	Furin_repeat	PCSK5 PCSK4	2.81e-04	18	26	2	IPR006212
Domain	FU	PCSK5 PCSK4	2.81e-04	18	26	2	SM00261
Domain	7TM_GPCR_Srsx	HTR1D NPY5R HTR1F	4.94e-04	112	26	3	SM01381
Domain	Growth_fac_rcpt_	PCSK5 CRIM1 PCSK4	1.29e-03	156	26	3	IPR009030
Domain	Keratin_B2_2	KRTAP4-3 KRTAP10-11	1.34e-03	39	26	2	PF13885
Domain	Keratin_B2	KRTAP4-3 KRTAP10-11	1.41e-03	40	26	2	PF01500
Domain	KAP	KRTAP4-3 KRTAP10-11	2.94e-03	58	26	2	IPR002494
Domain	LIM	LHX8 MICALL2	4.13e-03	69	26	2	PF00412
Domain	-	LHX8 MICALL2	4.25e-03	70	26	2	2.10.110.10
Domain	LIM_DOMAIN_2	LHX8 MICALL2	4.37e-03	71	26	2	PS50023
Domain	Znf_LIM	LHX8 MICALL2	4.37e-03	71	26	2	IPR001781
Domain	LIM_DOMAIN_1	LHX8 MICALL2	4.37e-03	71	26	2	PS00478
Domain	LIM	LHX8 MICALL2	4.37e-03	71	26	2	SM00132
Domain	-	PCSK5 PCSK4	4.61e-03	73	26	2	2.60.120.260
Domain	Galactose-bd-like	PCSK5 PCSK4	7.53e-03	94	26	2	IPR008979
Domain	Znf_FYVE_PHD	ZFYVE28 KDM5A	1.77e-02	147	26	2	IPR011011
Pathway	REACTOME_SEROTONIN_RECEPTORS	HTR1D HTR1F	1.04e-04	11	20	2	MM15008
Pathway	REACTOME_SEROTONIN_RECEPTORS	HTR1D HTR1F	1.25e-04	12	20	2	M6034
Pathway	WP_MONOAMINE_GPCRS	HTR1D HTR1F	8.68e-04	31	20	2	MM15871
Pathway	WP_MONOAMINE_GPCRS	HTR1D HTR1F	9.83e-04	33	20	2	M39585
Pathway	WP_SEROTONIN_HTR1_GROUP_AND_FOS_PATHWAY	HTR1D HTR1F	1.24e-03	37	20	2	M42558
Pathway	REACTOME_KERATINIZATION	KRTAP4-3 KRTAP13-3 KRTAP10-11	1.25e-03	153	20	3	MM15343
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	HTR1D HTR1F	1.59e-03	42	20	2	MM14971
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	HTR1D HTR1F	1.59e-03	42	20	2	M5868
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	HTR1D NPY5R HTR1F	2.18e-03	186	20	3	MM15994
Pubmed	Single-nucleotide polymorphisms of the proprotein convertase subtilisin/ kexin type 5 (PCSK5) gene.	PCSK5 PCSK4	5.80e-07	2	27	2	11776387
Pubmed	5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.	HTR1D HTR1F	1.74e-06	3	27	2	12110114
Pubmed	Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development.	HTR1D HTR1F	3.48e-06	4	27	2	16824687
Pubmed	Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?	HTR1D PLXNA2	8.69e-06	6	27	2	20633049
Pubmed	GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.	WNT2 PLXNA2	8.69e-06	6	27	2	19666519
Pubmed	Proteolytic processing in the secretory pathway.	PCSK5 PCSK4	1.22e-05	7	27	2	10409610
Pubmed	Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers.	HTR1D HTR1F	1.22e-05	7	27	2	12627464
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK5 PCSK4	1.22e-05	7	27	2	7819324
Pubmed	5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis.	HTR1D HTR1F	1.62e-05	8	27	2	35550066
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK5 PCSK4	1.62e-05	8	27	2	9885250
Pubmed	Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.	PCSK5 PCSK4	1.62e-05	8	27	2	7782070
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK5 PCSK4	2.08e-05	9	27	2	23775089
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK5 PCSK4	2.08e-05	9	27	2	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK5 PCSK4	2.08e-05	9	27	2	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK5 PCSK4	2.08e-05	9	27	2	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK5 PCSK4	2.08e-05	9	27	2	22679642
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK5 PCSK4	2.08e-05	9	27	2	8698813
Pubmed	Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair.	KRTAP4-3 KRTAP13-3 KRTAP10-11	2.11e-05	69	27	3	18721477
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK5 PCSK4	2.60e-05	10	27	2	16163737
Pubmed	Association study of the serotoninergic system in migraine in the Spanish population.	HTR1D HTR1F	8.81e-05	18	27	2	19455600
Pubmed	Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.	DACT1 WNT2	1.21e-04	21	27	2	17943183
Pubmed	A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.	HTR1D HTR1F	2.17e-04	28	27	2	19737523
Pubmed	Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease.	CRIM1 PLXNA2	2.17e-04	28	27	2	33953184
Pubmed	Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.	WNT2 PLXNA2	2.66e-04	31	27	2	25053429
Pubmed	Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate.	WNT2 PLXNA2	3.21e-04	34	27	2	31024170
Pubmed	5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.	HTR1D HTR1F	3.40e-04	35	27	2	28031476
Pubmed	Dissociation of heterotrimeric g proteins in cells.	HTR1D NPY5R HTR1F	3.58e-04	179	27	3	18577758
Pubmed	Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21.	KRTAP4-3 KRTAP4-16	3.80e-04	37	27	2	11279113
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	FAM193A CRIM1 SPATA2	3.88e-04	184	27	3	32908313
Pubmed	AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity.	WNT2 PLXNA2	4.45e-04	40	27	2	24680892
Interaction	KRTAP3-2 interactions	PCSK5 POGZ KRTAP13-3	9.70e-05	79	23	3	int:KRTAP3-2
Interaction	POU4F2 interactions	PCSK5 KRTAP13-3 KRTAP10-11	1.12e-04	83	23	3	int:POU4F2
Interaction	KRTAP13-3 interactions	PCSK5 KRTAP13-3 KRTAP10-11	1.21e-04	85	23	3	int:KRTAP13-3
Cytoband	17q12-q21	KRTAP4-3 KRTAP4-16	1.63e-04	32	27	2	17q12-q21
Cytoband	4p16.3	ZFYVE28 FAM193A	1.15e-03	85	27	2	4p16.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	ZFYVE28 FAM193A	7.55e-03	222	27	2	chr4p16
GeneFamily	Keratin associated proteins	KRTAP4-3 KRTAP4-16 KRTAP13-3 KRTAP10-11	6.91e-06	109	21	4	619
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK5 PCSK4	4.60e-05	9	21	2	973
GeneFamily	5-hydroxytryptamine receptors, G protein-coupled	HTR1D HTR1F	9.95e-05	13	21	2	170
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SPATA2 TRPC5	1.85e-02	181	21	2	694
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500	DACT1 FAM193A LHX8 WNT2 PLXNA2	3.99e-05	407	21	5	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
Drug	Rizatriptan	HTR1D HTR1F	4.06e-06	3	27	2	DB00953
Drug	p-MPPI	HTR1D HTR1F WNT2	5.32e-06	29	27	3	CID000004658
Drug	Zolmitriptan	HTR1D HTR1F	8.11e-06	4	27	2	DB00315
Drug	Naratriptan	HTR1D HTR1F	8.11e-06	4	27	2	DB00952
Drug	Is 159	HTR1D HTR1F	8.11e-06	4	27	2	CID000196859
Drug	Sumatriptan	HTR1D HTR1F	8.11e-06	4	27	2	DB00669
Drug	Trelibet	HTR1D HTR1F	1.35e-05	5	27	2	CID000065975
Drug	4-amino-5-chloro-2-methoxybenzamide	HTR1D HTR1F	1.35e-05	5	27	2	CID009834239
Drug	centbutindole	HTR1D HTR1F	1.35e-05	5	27	2	CID000068663
Drug	I 370	HTR1D HTR1F	1.35e-05	5	27	2	CID000089576
Drug	CP-132,484	HTR1D HTR1F	1.35e-05	5	27	2	CID000132564
Drug	AC1LCKBJ	HTR1D HTR1F	1.35e-05	5	27	2	CID000601768
Drug	pyrrolo(1,2-a)quinoxaline	HTR1D HTR1F	2.03e-05	6	27	2	CID000067476
Drug	R 28935	HTR1D HTR1F	2.03e-05	6	27	2	CID000093307
Drug	LY334370	HTR1D HTR1F	2.83e-05	7	27	2	CID005311258
Drug	adafenoxate	HTR1D HTR1F	2.83e-05	7	27	2	CID000064517
Drug	Eletriptan	HTR1D HTR1F	2.83e-05	7	27	2	DB00216
Drug	BRL 34778	HTR1D HTR1F	2.83e-05	7	27	2	CID000135770
Drug	AC1L5AAF	HTR1D HTR1F	3.78e-05	8	27	2	CID000173615
Drug	cinitapride	HTR1D HTR1F	3.78e-05	8	27	2	CID000068867
Drug	5-fluoro-alpha-methyltryptamine	HTR1D HTR1F	3.78e-05	8	27	2	CID000012834
Drug	avitriptan	HTR1D HTR1F	3.78e-05	8	27	2	CID000133081
Drug	CQ 32-084	HTR1D HTR1F	4.85e-05	9	27	2	CID000068847
Drug	melantonin	HTR1D HTR1F	4.85e-05	9	27	2	CID000077899
Drug	AHPP	HTR1D HTR1F	4.85e-05	9	27	2	CID000128891
Drug	tetralin	HTR1D NPY5R HTR1F	5.63e-05	63	27	3	CID000008404
Drug	seganserin	HTR1D HTR1F	6.06e-05	10	27	2	CID000071767
Drug	AC1L1CCX	HTR1D HTR1F	6.06e-05	10	27	2	CID000001840
Drug	LY344864	HTR1D HTR1F	6.06e-05	10	27	2	CID005311097
Drug	CM 29-712	HTR1D HTR1F	6.06e-05	10	27	2	CID000159842
Drug	5-HTQ	HTR1D HTR1F	6.06e-05	10	27	2	CID000656705
Drug	cyclandelate	HTR1D HTR1F	7.40e-05	11	27	2	CID000002893
Drug	alniditan	HTR1D HTR1F	7.40e-05	11	27	2	CID000066004
Drug	sergolexole	HTR1D HTR1F	8.87e-05	12	27	2	CID000060262
Drug	BRL15572	HTR1D HTR1F	8.87e-05	12	27	2	CID003654103
Drug	ocaperidone	HTR1D HTR1F	8.87e-05	12	27	2	CID000071351
Drug	MDL 72832	HTR1D HTR1F	1.05e-04	13	27	2	CID000182585
Drug	anpirtoline	HTR1D HTR1F	1.05e-04	13	27	2	CID000065854
Drug	CP-122,288	HTR1D HTR1F	1.05e-04	13	27	2	CID000132552
Drug	NSC196867	HTR1D HTR1F	1.05e-04	13	27	2	CID000003982
Drug	L-694,247	HTR1D HTR1F	1.22e-04	14	27	2	CID000132059
Drug	FMMT	HTR1D HTR1F	1.22e-04	14	27	2	CID006438682
Drug	asperflavin	HTR1D HTR1F	1.41e-04	15	27	2	CID000004724
Drug	5-nonyloxytryptamine	HTR1D HTR1F	1.61e-04	16	27	2	CID000001797
Drug	San 21009	HTR1D HTR1F	1.82e-04	17	27	2	CID000152662
Drug	DP-5-CT	HTR1D HTR1F	2.05e-04	18	27	2	CID000156314
Drug	benzoctamine	HTR1D HTR1F	2.05e-04	18	27	2	CID000028425
Drug	pAPP	HTR1D HTR1F	2.05e-04	18	27	2	CID000121930
Drug	AC1L1I6G	HTR1D HTR1F	2.29e-04	19	27	2	CID000004442
Drug	ICI 169,369	HTR1D HTR1F	2.54e-04	20	27	2	CID000122265
Drug	triptan	HTR1D HTR1F	2.54e-04	20	27	2	CID000010044
Drug	6-nitroquipazine	HTR1D HTR1F	2.54e-04	20	27	2	CID000005012
Drug	5-fluoro-8-hydroxy-2-(dipropylamino)tetralin	HTR1D HTR1F	2.54e-04	20	27	2	CID000005122
Drug	SB224289	HTR1D HTR1F	2.54e-04	20	27	2	CID003378093
Drug	benzimidazolone	HTR1D NPY5R	2.80e-04	21	27	2	CID000088638
Drug	eltoprazine	HTR1D HTR1F	2.80e-04	21	27	2	CID000065853
Drug	BW 723C86	HTR1D HTR1F	3.08e-04	22	27	2	CID004284720
Drug	tertatolol	HTR1D HTR1F	3.08e-04	22	27	2	CID000036920
Drug	zacopride	HTR1D HTR1F	3.08e-04	22	27	2	CID000108182
Drug	GR127935	HTR1D HTR1F	3.08e-04	22	27	2	CID000107780
Drug	mCPBG	HTR1D HTR1F	3.08e-04	22	27	2	CID000001354
Drug	alpha-methylserotonin	HTR1D HTR1F	3.08e-04	22	27	2	CID000115292
Drug	pindobind	HTR1D HTR1F	3.37e-04	23	27	2	CID000004827
Drug	SDZ 205-557	HTR1D HTR1F	3.68e-04	24	27	2	CID000005191
Drug	AC1L1K7Z	HTR1D HTR1F	3.68e-04	24	27	2	CID000005378
Drug	GR113808	HTR1D HTR1F	4.00e-04	25	27	2	CID000119376
Drug	pizotifen	HTR1D HTR1F	4.00e-04	25	27	2	CID000027400
Drug	naratriptan	HTR1D HTR1F	4.00e-04	25	27	2	CID000004440
Drug	1-(1-naphthyl)piperazine	HTR1D HTR1F	4.32e-04	26	27	2	CID000001342
Drug	CP-93,129	HTR1D HTR1F	4.67e-04	27	27	2	CID000124007
Drug	MK-212	HTR1D HTR1F	4.67e-04	27	27	2	CID000107992
Drug	NSC169490	HTR1D HTR1F	4.67e-04	27	27	2	CID004210613
Drug	rizatriptan	HTR1D HTR1F	4.67e-04	27	27	2	CID000005078
Drug	ergolines	HTR1D HTR1F	4.67e-04	27	27	2	CID003083577
Drug	bufotenine	HTR1D HTR1F	4.67e-04	27	27	2	CID000010257
Drug	NSC407316	HTR1D HTR1F	5.02e-04	28	27	2	CID000003067
Drug	WAY 100135	HTR1D HTR1F	5.39e-04	29	27	2	CID000115111
Drug	D02568	HTR1D HTR1F	5.39e-04	29	27	2	CID011954254
Drug	AscoTop	HTR1D HTR1F	5.39e-04	29	27	2	CID000005731
Drug	AC1L1G8Z	HTR1D HTR1F	5.77e-04	30	27	2	CID000003581
Drug	isopropylaniline	HTR1D HTR1F	6.17e-04	31	27	2	CID000013032
Drug	mesulergine	HTR1D HTR1F	6.17e-04	31	27	2	CID000068848
Drug	xanomeline	HTR1D HTR1F	6.17e-04	31	27	2	CID000060809
Drug	psychogenic	HTR1D HTR1F	6.17e-04	31	27	2	CID000006089
Drug	pirenperone	HTR1D HTR1F	6.99e-04	33	27	2	CID000004847
Drug	phenylbiguanide	HTR1D HTR1F	7.42e-04	34	27	2	CID000004780
Drug	MDL 72222	HTR1D HTR1F	7.42e-04	34	27	2	CID000001683
Drug	urapidil	HTR1D HTR1F	7.42e-04	34	27	2	CID000005639
Drug	CGS 12066B	HTR1D HTR1F	7.42e-04	34	27	2	CID000002689
Drug	Chloroprene	PCSK5 POGZ FAM193A CRIM1 KDM5A WNT2 PLXNA2	7.81e-04	1348	27	7	ctd:D002737
Drug	molindone	HTR1D HTR1F	8.32e-04	36	27	2	CID000023897
Drug	TFMPP	HTR1D HTR1F	8.79e-04	37	27	2	CID000004296
Drug	ICS-205,930	HTR1D HTR1F	8.79e-04	37	27	2	CID000005595
Drug	norfenfluramine	HTR1D HTR1F	8.79e-04	37	27	2	CID000015897
Drug	2-aminothiazol	HTR1D NPY5R	9.27e-04	38	27	2	CID000002155
Drug	pipamperone	HTR1D HTR1F	9.27e-04	38	27	2	CID000004830
Drug	almotriptan	HTR1D HTR1F	9.27e-04	38	27	2	CID000123606
Drug	AC1L1H4K	HTR1D HTR1F	9.77e-04	39	27	2	CID000003972
Drug	AC1NUW4G	HTR1D HTR1F	1.03e-03	40	27	2	CID005462134
Drug	NSC95090	HTR1D HTR1F	1.03e-03	40	27	2	CID000003251
Disease	bitter alcoholic beverage consumption measurement	FBXO40 MICALL2 PLXNA2	1.69e-04	133	24	3	EFO_0010092
Disease	autism spectrum disorder (implicated_via_orthology)	POGZ KDM5A TRPC5	2.51e-04	152	24	3	DOID:0060041 (implicated_via_orthology)
Disease	body fat distribution	PCSK5 XKR6 MICALL2	5.75e-04	202	24	3	EFO_0004341
Disease	physical activity measurement	XKR6 HTR1F CRIM1	1.01e-03	245	24	3	EFO_0008002
Disease	neuroticism measurement, cognitive function measurement	HTR1D XKR6 FAM193A LHX8	1.05e-03	566	24	4	EFO_0007660, EFO_0008354
Disease	Autistic Disorder	FBXO40 HTR1D WNT2	1.21e-03	261	24	3	C0004352
Disease	intellectual disability (implicated_via_orthology)	POGZ KDM5A	1.70e-03	75	24	2	DOID:1059 (implicated_via_orthology)
Disease	hippocampal volume	DACT1 XKR6 PLXNA2	1.75e-03	297	24	3	EFO_0005035
Disease	cortical thickness	DACT1 HTR1D XKR6 CRIM1 PLXNA2	1.77e-03	1113	24	5	EFO_0004840
Disease	smoking behavior	XKR6 PLXNA2 TRPC5	2.59e-03	341	24	3	EFO_0004318
Disease	intelligence, self reported educational attainment	DENND4A FAM193A	4.06e-03	117	24	2	EFO_0004337, EFO_0004784
Disease	pursuit maintenance gain measurement	PCSK5 PLXNA2	4.48e-03	123	24	2	EFO_0008433
Disease	prostate cancer (is_marker_for)	KDM5A WNT2	7.10e-03	156	24	2	DOID:10283 (is_marker_for)
Disease	breast cancer (is_marker_for)	KDM5A WNT2	9.86e-03	185	24	2	DOID:1612 (is_marker_for)
Disease	health study participation	LHX8 PLXNA2	1.09e-02	195	24	2	EFO_0010130
Disease	alcohol use disorder (implicated_via_orthology)	NPY5R KDM5A	1.09e-02	195	24	2	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SVDITCCTCSILHLS	HTR1F	101	P30939
CACDDCSLSHILTCG	FAM193A	211	P78312
LISSCSRCRTCDCLV	DENND4A	1446	Q7Z401
ATNCLLHSCVCCGSC	ZFYVE28	556	Q9HCC9
SCFRCKQCSCTLHSG	MICALL2	211	Q8IY33
LRVCSSCHASCYTCR	PCSK4	646	Q6UW60
CHKSCLTCSSSGTCT	PCSK5	1421	Q92824
CSGERRCTLHQHCTS	PLXNA2	826	O75051
TTCCRTTSCSHSCSV	KRTAP4-16	31	G5E9R7
TTSCSHSCSVSSCCR	KRTAP4-16	36	G5E9R7
ISSCCHPSCCVSSCR	KRTAP4-3	156	Q9BYR4
HVRCLSCSVCRTSLG	LHX8	96	Q68G74
SCSVCRTSLGRHTSC	LHX8	101	Q68G74
CSACRTTCFLSALTC	KDM5A	676	P29375
SECLSSCHSSTCFCS	DACT1	181	Q9NYF0
CSVTTCCSLGRSCHL	GIMD1	41	P0DJR0
DSCTQCTCHSGRVLC	CRIM1	696	Q9NZV1
SSDITCCTASILHLC	HTR1D	116	P28221
TSCLVISCHLLCGAT	FBXO40	31	Q9UH90
SVSLLCHPVCRSTCC	KRTAP10-11	236	P60412
CQTLCVESSPCHTSC	KRTAP13-3	66	Q3SY46
SCCSLSCGSRSCSSL	KRTAP13-3	106	Q3SY46
CLRHKCCFSSSGTTS	FMR1NB	156	Q8N0W7
RCLAATSIICGCSCL	TMEM265	31	A0A087WTH1
CLTVSHTSVCRSISC	NPY5R	226	Q15761
VHCSLCRYSTCCSRA	POGZ	771	Q7Z3K3
SSSMHICHCCNTSSC	XKR6	51	Q5GH73
CGLSCSSSLCQRCDS	SPATA2	386	Q9UM82
CKCHGVSGSCTLRTC	WNT2	206	P09544
ACSSSLHCASSICSS	TRPC5	921	Q9UL62
RARLSVGLACCCSHT	TXNRD3NB	26	Q6F5E7