Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase binding	DAB2IP TRIB3 TRIB1	7.36e-05	19	87	3	GO:0031434
GeneOntologyMolecularFunction	HLA-A specific inhibitory MHC class I receptor activity	LILRB1 LILRB5	1.86e-04	5	87	2	GO:0030107
GeneOntologyMolecularFunction	HLA-B specific inhibitory MHC class I receptor activity	LILRB1 LILRB5	2.78e-04	6	87	2	GO:0030109
GeneOntologyMolecularFunction	MHC class Ib protein complex binding	LILRB1 LILRB5	3.89e-04	7	87	2	GO:0023025
GeneOntologyMolecularFunction	myosin light chain binding	SPATA6 IQGAP3	5.17e-04	8	87	2	GO:0032027
GeneOntologyMolecularFunction	14-3-3 protein binding	DAB2IP RIPOR2 KLHL22	8.11e-04	42	87	3	GO:0071889
Domain	FAM180	FAM180B FAM180A	2.19e-05	2	88	2	IPR029170
Domain	FAM180	FAM180B FAM180A	2.19e-05	2	88	2	PF15173
Domain	Tribbles/Ser_Thr_kinase_40	TRIB3 TRIB1	1.31e-04	4	88	2	IPR024104
Domain	ARM-type_fold	USP34 RIPOR2 MROH6 PKP2 INTS4 CUL9 RYR3	1.10e-03	339	88	7	IPR016024
Domain	BAH	ORC1 BAHD1	1.17e-03	11	88	2	SM00439
Domain	BAH	ORC1 BAHD1	1.17e-03	11	88	2	PF01426
Domain	BAH	ORC1 BAHD1	1.17e-03	11	88	2	PS51038
Domain	BAH_dom	ORC1 BAHD1	1.17e-03	11	88	2	IPR001025
Domain	RasGAP	DAB2IP IQGAP3	1.93e-03	14	88	2	SM00323
Domain	RasGAP_CS	DAB2IP IQGAP3	1.93e-03	14	88	2	IPR023152
Domain	PH	DAB2IP PLEKHG7 ARHGEF4 TIAM2 FERMT3 MPRIP	2.01e-03	278	88	6	SM00233
Domain	PH_DOMAIN	DAB2IP PLEKHG7 ARHGEF4 TIAM2 FERMT3 MPRIP	2.05e-03	279	88	6	PS50003
Domain	PH_domain	DAB2IP PLEKHG7 ARHGEF4 TIAM2 FERMT3 MPRIP	2.09e-03	280	88	6	IPR001849
Domain	ATPase_AAA_core	ORC1 CLPB ATAD5	2.11e-03	54	88	3	IPR003959
Domain	RasGAP	DAB2IP IQGAP3	2.21e-03	15	88	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	DAB2IP IQGAP3	2.21e-03	15	88	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	DAB2IP IQGAP3	2.21e-03	15	88	2	PS50018
Domain	-	DAB2IP IQGAP3	2.52e-03	16	88	2	1.10.506.10
Domain	RasGAP_dom	DAB2IP IQGAP3	3.20e-03	18	88	2	IPR001936
Domain	DH_1	PLEKHG7 ARHGEF4 TIAM2	3.27e-03	63	88	3	PS00741
Domain	C2	DAB2IP ESYT1 PLA2G4F RIMS1	3.42e-03	131	88	4	PF00168
Domain	-	RIPOR2 MROH6 PKP2 INTS4 CUL9	4.00e-03	222	88	5	1.25.10.10
Domain	C2	DAB2IP ESYT1 PLA2G4F RIMS1	4.01e-03	137	88	4	SM00239
Domain	RhoGEF	PLEKHG7 ARHGEF4 TIAM2	4.06e-03	68	88	3	SM00325
Domain	RhoGEF	PLEKHG7 ARHGEF4 TIAM2	4.41e-03	70	88	3	PF00621
Domain	DH_2	PLEKHG7 ARHGEF4 TIAM2	4.41e-03	70	88	3	PS50010
Domain	C2	DAB2IP ESYT1 PLA2G4F RIMS1	4.56e-03	142	88	4	PS50004
Domain	DH-domain	PLEKHG7 ARHGEF4 TIAM2	4.59e-03	71	88	3	IPR000219
Domain	-	PLEKHG7 ARHGEF4 TIAM2	4.59e-03	71	88	3	1.20.900.10
Domain	AAA+_ATPase	ORC1 CLPB ATAD5 DNAH2	4.79e-03	144	88	4	IPR003593
Domain	AAA	ORC1 CLPB ATAD5 DNAH2	4.79e-03	144	88	4	SM00382
Domain	-	DAB2IP ESYT1 PLA2G4F RIMS1	5.28e-03	148	88	4	2.60.40.150
Domain	P-loop_NTPase	WSCD1 ORC1 CLPB ATAD5 SPEF2 DNAH2 MYO15A GTPBP3 ELP4 KIF7	6.49e-03	848	88	10	IPR027417
Domain	C2_dom	DAB2IP ESYT1 PLA2G4F RIMS1	7.55e-03	164	88	4	IPR000008
Domain	-	WSCD1 ORC1 CLPB ATAD5 SPEF2 DNAH2 MYO15A GTPBP3 ELP4	8.46e-03	746	88	9	3.40.50.300
Domain	ARM-like	RIPOR2 MROH6 PKP2 INTS4 CUL9	9.00e-03	270	88	5	IPR011989
Domain	Leu-rich_rpt	LRRC66 CARMIL3 LRRC26 FBXO39 LRRC41	9.13e-03	271	88	5	IPR001611
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP ENGASE ORC1 USP34 TRIB3 MROH6 NAPRT ESYT1 CUL9 ARHGEF4 PC TRIB1 BAHD1 IQGAP3 TIAM2 MPRIP	2.70e-08	1105	91	16	35748872
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	DAB2IP SPEF2 DCLK3 CFAP74 CEP295 CCSER1	2.99e-07	102	91	6	11214970
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CEP170 USP34 HTRA1 ATAD5 ZC3H4 PRSS56 PKP2 CUL9 CEP295 TSR3 LRRC41 KIF7 TBX2	6.74e-06	1116	91	13	31753913
Pubmed	Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia.	DAB2IP KMT2A	6.77e-06	2	91	2	14978793
Pubmed	Infiltrating T cells promote renal cell carcinoma (RCC) progression via altering the estrogen receptor β-DAB2IP signals.	DAB2IP ESR2	6.77e-06	2	91	2	26587829
Pubmed	The tribbles gene family and lipoprotein metabolism.	TRIB3 TRIB1	6.77e-06	2	91	2	22274752
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ORC1 SPEF2 KMT2A RIMS1 IQGAP3 MPRIP	1.86e-05	208	91	6	33230847
Pubmed	Tribbles: novel regulators of cell function; evolutionary aspects.	TRIB3 TRIB1	2.03e-05	3	91	2	16715410
Pubmed	Tribbles in acute leukemia.	TRIB3 TRIB1	2.03e-05	3	91	2	23550039
Pubmed	Pseudokinases: a tribble-edged sword.	TRIB3 TRIB1	2.03e-05	3	91	2	31621188
Pubmed	Tribbles role in reproduction.	TRIB3 TRIB1	2.03e-05	3	91	2	26517934
Pubmed	Tribbles in inflammation.	TRIB3 TRIB1	2.03e-05	3	91	2	26517925
Pubmed	Tribbles and arthritis: what are the links?	TRIB3 TRIB1	2.03e-05	3	91	2	26517922
Pubmed	Tribbles pseudokinases: novel targets for chemical biology and drug discovery?	TRIB3 TRIB1	2.03e-05	3	91	2	26517930
Pubmed	Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development.	TRIB3 TRIB1	2.03e-05	3	91	2	18593568
Pubmed	Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis.	TRIB3 TRIB1	2.03e-05	3	91	2	30031847
Pubmed	Upregulation of Tribbles decreases body weight and increases sleep duration.	TRIB3 TRIB1	2.03e-05	3	91	2	37083954
Pubmed	Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism.	TRIB3 TRIB1	2.03e-05	3	91	2	24834131
Pubmed	SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.	TRIB3 TRIB1	4.05e-05	4	91	2	12736262
Pubmed	Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet.	TRIB3 TRIB1	4.05e-05	4	91	2	24732777
Pubmed	Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.	TRIB3 TRIB1	4.05e-05	4	91	2	34128473
Pubmed	Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.	TRIB3 TRIB1	6.74e-05	5	91	2	20410507
Pubmed	Regulation of cytotoxic T lymphocyte triggering by PIR-B on dendritic cells.	LILRB1 LILRB5	6.74e-05	5	91	2	18787130
Pubmed	PIR-B Regulates CD4+ IL17a+ T-Cell Survival and Restricts T-Cell-Dependent Intestinal Inflammatory Responses.	LILRB1 LILRB5	6.74e-05	5	91	2	34242819
Pubmed	Role of PIR-B in autoimmune glomerulonephritis.	LILRB1 LILRB5	6.74e-05	5	91	2	20976309
Pubmed	Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury.	LILRB1 LILRB5	6.74e-05	5	91	2	20881122
Pubmed	PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury.	LILRB1 LILRB5	6.74e-05	5	91	2	27443384
Pubmed	The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling.	LILRB1 LILRB5	6.74e-05	5	91	2	15494528
Pubmed	Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses.	LILRB1 LILRB5	6.74e-05	5	91	2	19684158
Pubmed	PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation.	LILRB1 LILRB5	6.74e-05	5	91	2	37146940
Pubmed	PirB functions as an intrinsic suppressor in hippocampal neural stem cells.	LILRB1 LILRB5	6.74e-05	5	91	2	34120891
Pubmed	Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.	TRIB3 TRIB1	6.74e-05	5	91	2	23515163
Pubmed	PirB regulates a structural substrate for cortical plasticity.	LILRB1 LILRB5	6.74e-05	5	91	2	24302763
Pubmed	The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.	TRIB3 TRIB1	6.74e-05	5	91	2	30692133
Pubmed	Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia.	LILRB1 LILRB5	6.74e-05	5	91	2	23927735
Pubmed	Enhancing motor learning by increasing the stability of newly formed dendritic spines in the motor cortex.	LILRB1 LILRB5	6.74e-05	5	91	2	34437845
Pubmed	Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus.	LILRB1 LILRB5	6.74e-05	5	91	2	37147336
Pubmed	Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity.	LILRB1 LILRB5	6.74e-05	5	91	2	33653799
Pubmed	Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury.	LILRB1 LILRB5	6.74e-05	5	91	2	21087927
Pubmed	Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis.	LILRB1 LILRB5	6.74e-05	5	91	2	20398663
Pubmed	Structure and flexibility of the extracellular region of the PirB receptor.	LILRB1 LILRB5	6.74e-05	5	91	2	30674550
Pubmed	Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.	LILRB1 LILRB5	6.74e-05	5	91	2	23152562
Pubmed	Regulation of plasmacytoid dendritic cell responses by PIR-B.	LILRB1 LILRB5	6.74e-05	5	91	2	22948046
Pubmed	Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.	LILRB1 LILRB5	6.74e-05	5	91	2	9054430
Pubmed	TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta.	TRIB3 TRIB1	6.74e-05	5	91	2	17576771
Pubmed	Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B.	LILRB1 LILRB5	6.74e-05	5	91	2	10359805
Pubmed	Paired Ig-like Receptor B Inhibits IL-13-Driven Eosinophil Accumulation and Activation in the Esophagus.	LILRB1 LILRB5	6.74e-05	5	91	2	27324131
Pubmed	Characterization of paired Ig-like receptors in rats.	LILRB1 LILRB5	6.74e-05	5	91	2	10586026
Pubmed	Paired immunoglobulin-like receptor B regulates platelet activation.	LILRB1 LILRB5	6.74e-05	5	91	2	25075127
Pubmed	Genomic structure of PIR-B, the inhibitory member of the paired immunoglobulin-like receptor genes in mice.	LILRB1 LILRB5	6.74e-05	5	91	2	9550322
Pubmed	Expression of PirB protein in intact and injured optic nerve and retina of mice.	LILRB1 LILRB5	6.74e-05	5	91	2	22102155
Pubmed	Paired immunoglobulin-like receptors and their MHC class I recognition.	LILRB1 LILRB5	6.74e-05	5	91	2	16011512
Pubmed	Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages.	LILRB1 LILRB5	6.74e-05	5	91	2	23258232
Pubmed	Mast cell regulation via paired immunoglobulin-like receptor PIR-B.	LILRB1 LILRB5	6.74e-05	5	91	2	12403357
Pubmed	Autoimmune arthritis induces paired immunoglobulin-like receptor B expression on CD4+ T cells from SKG mice.	LILRB1 LILRB5	1.01e-04	6	91	2	28664612
Pubmed	HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor.	LILRB1 LILRB5	1.01e-04	6	91	2	12207326
Pubmed	Cell-Autonomous Regulation of Dendritic Spine Density by PirB.	LILRB1 LILRB5	1.01e-04	6	91	2	27752542
Pubmed	Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.	TRIB3 TRIB1	1.01e-04	6	91	2	15299019
Pubmed	The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate.	LILRB1 LILRB5	1.01e-04	6	91	2	9824165
Pubmed	CaSSiDI: novel single-cell "Cluster Similarity Scoring and Distinction Index" reveals critical functions for PirB and context-dependent Cebpb repression.	LILRB1 LILRB5	1.01e-04	6	91	2	38383888
Pubmed	Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway.	LILRB1 LILRB5	1.01e-04	6	91	2	39095838
Pubmed	PirB is a functional receptor for myelin inhibitors of axonal regeneration.	LILRB1 LILRB5	1.01e-04	6	91	2	18988857
Pubmed	Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.	LILRB1 LILRB5	1.01e-04	6	91	2	27402837
Pubmed	PirB regulates asymmetries in hippocampal circuitry.	LILRB1 LILRB5	1.01e-04	6	91	2	28594961
Pubmed	The p75 receptor mediates axon growth inhibition through an association with PIR-B.	LILRB1 LILRB5	1.01e-04	6	91	2	21881600
Pubmed	Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice.	LILRB1 LILRB5	1.01e-04	6	91	2	12021780
Pubmed	Exacerbated graft-versus-host disease in Pirb-/- mice.	LILRB1 LILRB5	1.01e-04	6	91	2	15146181
Pubmed	PIR-B-deficient mice are susceptible to Salmonella infection.	LILRB1 LILRB5	1.01e-04	6	91	2	18768880
Pubmed	CAMKs support development of acute myeloid leukemia.	LILRB1 LILRB5	1.01e-04	6	91	2	29482582
Pubmed	LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis.	LILRB1 LILRB5	1.01e-04	6	91	2	37481670
Pubmed	Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.	LILRB1 LILRB5	1.01e-04	6	91	2	31727773
Pubmed	Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia.	LILRB1 LILRB5	1.01e-04	6	91	2	25320232
Pubmed	Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance.	LILRB1 LILRB5	1.01e-04	6	91	2	30787106
Pubmed	Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells.	LILRB1 LILRB5	1.01e-04	6	91	2	21636572
Pubmed	Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation.	LILRB1 LILRB5	1.01e-04	6	91	2	24040397
Pubmed	Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5-induced eosinophil development.	LILRB1 LILRB5	1.01e-04	6	91	2	24212998
Pubmed	Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.	LILRB1 LILRB5	1.01e-04	6	91	2	30068593
Pubmed	Genome-wide association study of chronic periodontitis in a general German population.	PLEKHG7 FAM180A FAM135B RYR3	1.21e-04	96	91	4	24024966
Pubmed	LOTUS suppresses amyloid β-induced dendritic spine elimination through the blockade of amyloid β binding to PirB.	LILRB1 LILRB5	1.41e-04	7	91	2	36510132
Pubmed	Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.	LILRB1 LILRB5	1.41e-04	7	91	2	19687229
Pubmed	Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.	LILRB1 LILRB5	1.41e-04	7	91	2	17998301
Pubmed	PirB restricts ocular-dominance plasticity in visual cortex.	LILRB1 LILRB5	1.41e-04	7	91	2	16917027
Pubmed	Macrophage Paired Immunoglobulin-Like Receptor B Deficiency Promotes Peripheral Atherosclerosis in Apolipoprotein E-Deficient Mice.	LILRB1 LILRB5	1.41e-04	7	91	2	35321392
Pubmed	Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.	LILRB1 LILRB5	1.41e-04	7	91	2	20844138
Pubmed	Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production.	LILRB1 LILRB5	1.41e-04	7	91	2	17371981
Pubmed	Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3.	LILRB1 LILRB5	1.41e-04	7	91	2	21555536
Pubmed	The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling.	LILRB1 LILRB5	1.41e-04	7	91	2	24278366
Pubmed	Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation.	ILK FERMT3	1.41e-04	7	91	2	25086068
Pubmed	A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils.	LILRB1 LILRB5	1.41e-04	7	91	2	18316626
Pubmed	NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1.	LILRB1 LILRB5	1.41e-04	7	91	2	27897222
Pubmed	Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.	LILRB1 LILRB5	1.88e-04	8	91	2	22660330
Pubmed	A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.	LILRB1 LILRB5	1.88e-04	8	91	2	9548455
Pubmed	Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.	LILRB1 LILRB5	1.88e-04	8	91	2	21376641
Pubmed	An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR).	LILRB1 LILRB5	1.88e-04	8	91	2	18209065
Pubmed	NogoR1 and PirB signaling stimulates neural stem cell survival and proliferation.	LILRB1 LILRB5	1.88e-04	8	91	2	24449409
Pubmed	The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina.	LILRB1 LILRB5	1.88e-04	8	91	2	19255189
Pubmed	Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family.	LILRB1 LILRB5	1.88e-04	8	91	2	9538215
Pubmed	The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.	ROBO3 KIF7	1.88e-04	8	91	2	31825820
Pubmed	VCAM1 confers innate immune tolerance on haematopoietic and leukaemic stem cells.	LILRB1 LILRB5	1.88e-04	8	91	2	35210567
Pubmed	Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation.	LILRB1 LILRB5	2.41e-04	9	91	2	17420263
Interaction	TOP3B interactions	DAB2IP ENGASE ORC1 USP34 TRIB3 MROH6 NAPRT ESYT1 PKP2 CUL9 ACIN1 PATL1 ARHGEF4 TSR3 PC TRIB1 BAHD1 IQGAP3 TIAM2 MPRIP	3.36e-06	1470	87	20	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	RIN1 NAALADL1 CLPB CCDC87 PC FERMT3	2.97e-04	454	91	6	chr11q13
GeneFamily	CD molecules\|Inhibitory leukocyte immunoglobulin like receptors	LILRB1 LILRB5	8.38e-05	5	53	2	1182
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG7 ARHGEF4 TIAM2 FERMT3 MPRIP	3.37e-04	206	53	5	682
GeneFamily	AAA ATPases	ORC1 CLPB ATAD5	5.02e-04	53	53	3	413
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 GALNT10 COL9A1 HTRA1 SPATA6 NKX2-2	2.02e-06	182	91	6	8a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 GALNT10 COL9A1 HTRA1 SPATA6 NKX2-2	2.02e-06	182	91	6	e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 GALNT10 COL9A1 HTRA1 SPATA6 NKX2-2	2.22e-06	185	91	6	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 GALNT10 COL9A1 HTRA1 SPATA6 NKX2-2	2.22e-06	185	91	6	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ORC1 NAALADL1 ESR2 IQGAP3	9.65e-06	65	91	4	4382d56d5f71c7acfe35f84db7257aba2a7dd36a
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.C1ql3_(VTA_(dorsal_VTA))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ORC1 NAALADL1 ESR2 IQGAP3	9.65e-06	65	91	4	05b712f83d88e864747cd0229a39aca17321e0f8
ToppCell	facs-Marrow-Granulocytes-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 TRIB3 FAM180A PAM MPIG6B	1.67e-05	155	91	5	cd2f3ad4f131588325a667b6724e530d821fbe30
ToppCell	facs-Marrow-Granulocytes-3m-Hematologic-MPP_Fraction_B\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 TRIB3 FAM180A PAM MPIG6B	1.67e-05	155	91	5	9b26ade19488511c72b64335011d2dcd81e8f167
ToppCell	facs-Marrow-Granulocytes-3m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC66 TRIB3 FAM180A PAM MPIG6B	1.67e-05	155	91	5	4246709e27703b94529369abbed5763e4002e79d
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RIN1 DCLK3 PKP2 TIAM2 RYR3	1.94e-05	160	91	5	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RIN1 DCLK3 PKP2 TIAM2 RYR3	2.00e-05	161	91	5	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAM180B RIMS1 MPIG6B RYR3 CCSER1	2.06e-05	162	91	5	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	3'_v3-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Lung / Manually curated celltypes from each tissue	ORC1 ATAD5 ILDR1 IQGAP3 HSPB8	2.12e-05	163	91	5	47300dec94dc66e965bf71fafff0a9fd24fae968
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	DAB2IP RIN1 FAM180A ROBO3 HSPB8	2.38e-05	167	91	5	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|World / disease group, cell group and cell class (v2)	ESYT1 GTPBP3 MPRIP KLHL22 CCSER1	2.52e-05	169	91	5	2bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCell	mild_COVID-19_(asymptomatic)-RBC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	ESYT1 GTPBP3 MPRIP KLHL22 CCSER1	2.67e-05	171	91	5	78491478ba65bad45238fe114f5251b2adea323d
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ILK ROBO3 MPIG6B RGS10 FERMT3	2.75e-05	172	91	5	e39ea2f4edbf36ebf9604fa6f9349081859c596c
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ILK ROBO3 MPIG6B RGS10 FERMT3	2.75e-05	172	91	5	875ea290840e835952623b905eb610f3c71456d2
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ILK ROBO3 MPIG6B RGS10 FERMT3	2.75e-05	172	91	5	bcc50bed47465daa953ba91f17d1ee4c947ab461
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ORC1 COL9A1 NPB JMY	2.80e-05	85	91	4	159b3ac93490c3e4918ea61f8ede7add9e63ca40
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HTRA1 NRTN CEP295 RIMS1 IQGAP3	2.90e-05	174	91	5	7b2f35add804981c7d588a996bdbca6ec11a1ca5
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP HTRA1 FAM180A KMT2A PAM	3.41e-05	180	91	5	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP HTRA1 FAM180A KMT2A PAM	3.41e-05	180	91	5	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 COL9A1 HTRA1 SPATA6 NKX2-2	3.60e-05	182	91	5	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 COL9A1 HTRA1 SPATA6 NKX2-2	3.60e-05	182	91	5	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 GALNT10 COL9A1 HTRA1 SPATA6	3.89e-05	185	91	5	efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WSCD1 GALNT10 COL9A1 HTRA1 SPATA6	3.89e-05	185	91	5	fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RIN1 HTRA1 TRIB3 CFAP74 NMB	4.41e-05	190	91	5	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	P15-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HTRA1 FAM180A PAM TRIB1 HSPB8	4.87e-05	194	91	5	5f04d21c4e2d36e74b6c5889aa97fd98f75a0973
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-early_MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ILK PKP2 MPIG6B RYR3 FERMT3	4.99e-05	195	91	5	9b4f217325afb2efb9c65f298ac87649cb1e1af9
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ORC1 ADGRG7 ATAD5 PLEKHG7 MYO15A	5.37e-05	198	91	5	d5e125f0c4f41b47d567568d0838adcca7655f6d
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	CEP170 RIPOR2 KMT2A TIAM2 CCSER1	5.37e-05	198	91	5	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	COVID-19_Mild-PLT_1\|COVID-19_Mild / Disease Group and Platelet Clusters	RIPOR2 ILK MPIG6B RGS10 FERMT3	5.50e-05	199	91	5	7f32958a73bc6020ea8a0e595ec749bbfe74c1b3
Disease	Hereditary hearing loss and deafness	COL9A1 RIPOR2 ILDR1 MYO15A PC	8.23e-05	146	89	5	cv:C0236038
Disease	phosphate measurement	LEMD2 RYR3	1.87e-04	7	89	2	EFO_0010968
Disease	prostate adenocarcinoma (is_marker_for)	ILK PAM	3.98e-04	10	89	2	DOID:2526 (is_marker_for)
Disease	von Willebrand factor measurement, coronary artery disease	DAB2IP MPIG6B TRIB1 LINC00310	4.57e-04	118	89	4	EFO_0001645, EFO_0004629
Disease	leukocyte immunoglobulin-like receptor subfamily B member 2 measurement	LILRB1 LILRB5	4.86e-04	11	89	2	EFO_0008209
Disease	X-11315 measurement	MROH6 NAPRT	4.86e-04	11	89	2	EFO_0021223
Disease	creatine kinase measurement	NMB LILRB5 IQGAP3	7.63e-04	59	89	3	EFO_0004534
Disease	Myopia	COL9A1 PRSS56	9.21e-04	15	89	2	C0027092
Disease	Blood Platelet Disorders	MPIG6B FERMT3	1.05e-03	16	89	2	C0005818
Disease	interleukin 18 measurement	MROH6 NAPRT LILRB1	1.59e-03	76	89	3	EFO_0004581
Disease	Nonsyndromic genetic hearing loss	RIPOR2 ILDR1 MYO15A	1.59e-03	76	89	3	cv:C5680182
Disease	Nonsyndromic Deafness	RIPOR2 ILDR1 MYO15A	1.91e-03	81	89	3	C3711374
Disease	Sensorineural Hearing Loss (disorder)	COL9A1 RIPOR2	2.18e-03	23	89	2	C0018784
Disease	macular telangiectasia type 2	TRIB1 ELP4	2.79e-03	26	89	2	EFO_1002009
Disease	body composition measurement	ATAD5 PKP2 TRIB1 LINC00310	2.81e-03	193	89	4	EFO_0005106
Disease	Neurodevelopmental Disorders	ZC3H4 KMT2A RIMS1	2.83e-03	93	89	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
ATVPLRHSIRDRKPS	nan	21	A8MVM7
LERPELELSRHSPRK	ACIN1	191	Q9UKV3
IPLRRSSRHQTLPER	ATAD5	726	Q96QE3
AAEPPDHLTITRRRT	CEP170	1391	Q5SW79
PSSLLHTLRPRLLSA	LINC00310	21	P59036
LHLRLERLTPRPTAA	ESYT1	761	Q9BSJ8
LPLARHASLRLLSDP	GTPBP3	71	Q969Y2
IITSPESLNLPRRSH	ARHGEF4	106	Q9NR80
FHRLVSTLRPPESRV	PAM	461	P19021
PIFRRSINRRHDSLP	CCSER1	16	Q9C0I3
LPTLHERFRLLETSP	ADGRG7	766	Q96K78
HRLLRPLSLFPTRTT	CCDC87	16	Q9NVE4
SSRPTPILDLDIQRH	TFAP2D	361	Q7Z6R9
VSRLSRKRPPSDIHD	RGS10	6	O43665
LRDSLSHLVPALRLP	INTS4	576	Q96HW7
ALVPLHRLPRTLDAR	NRTN	36	Q99748
PRLKESRSHESLLSP	DAB2IP	126	Q5VWQ8
PLPRILRDVHTALST	DAB2IP	641	Q5VWQ8
LHLEPPKTRRVSSLR	FAM47C	786	Q5HY64
RDLSERALPRRSTSP	PATL1	166	Q86TB9
ASPLSPHRRAKSLDR	MPRIP	361	Q6WCQ1
PHRRAKSLDRRSTEP	MPRIP	366	Q6WCQ1
HAPRVRELLLDALSP	ESR2	251	Q92731
PDTDPLTRSIHEALR	JMY	951	Q8N9B5
ILHVRDSLIPPQSRR	LEMD2	441	Q8NC56
SLAELTLEPVHRRPE	NAA80	56	Q93015
SLEPPEELTQTRLHR	MYO15A	2661	Q9UKN7
LLRTVHSVLNRSPPE	GALNT10	161	Q86SR1
LRRDPFRDSPLSSRL	HSPB8	16	Q9UJY1
KARTRPLRASHDIVP	KIAA1614	381	Q5VZ46
LARHLTQLRTLSDPP	CARMIL3	856	Q8ND23
LTLAQHSRAPSPRLR	DCLK3	26	Q9C098
RPTLIDLLPTFRHTL	FBXO39	326	Q8N4B4
HLPPLIRDLSSSRRT	ILDR1	331	Q86SU0
TREETRDLVHAPLPL	KIF7	1261	Q2M1P5
QLHSLTLRREATEPP	LILRB5	556	O75023
SLVPLLLRLHDPSRD	MROH6	531	A6NGR9
PASLRLLQHTPSARR	C6orf223	196	Q8N319
ANTHLERIPASPRLR	RFPL4B	191	Q6ZWI9
LHNPSRLRTRLLTPQ	PLA2G4F	601	Q68DD2
RLLKRTPRPASTHDS	GPR78	311	Q96P69
PEPLRRHRSLTAHSL	IQGAP3	1416	Q86VI3
QSRISRETRLPPIHL	LRRC66	296	Q68CR7
RSLDEIHPTRRSRSP	RIMS1	976	Q86UR5
ARLRLHVSAVPESLP	ORC1	491	Q13415
SRRSERLHRPPVIVL	HTRA1	136	Q92743
RLHDKLDPSPLRDTV	KLHL22	256	Q53GT1
LEPLIPRHALNSRSV	ILK	311	Q13418
SQERELPLRLPRAHA	BAHD1	216	Q8TBE0
IPDIRRLSASLSSHP	FAM180A	101	Q6UWF9
LLRAPRFTPSEAHSR	KMT2A	696	Q03164
DHPLVRPDRSLREKL	CUL9	716	Q8IWT3
DSKTRRLDIRAPLHP	CLPB	686	Q9H078
RPRRETCHELPARIT	COL9A1	246	P20849
AETSSRHSLRPLRVP	ENGASE	531	Q8NFI3
ERLHLPPDLSDTVSR	ELP4	381	Q96EB1
PRTRSLHRALEETPK	FAM135B	891	Q49AJ0
PETLAEISRHPLRHR	FHIP2A	441	Q5W0V3
PSSHREIPRLQDRLL	CEP295	1576	Q9C0D2
PLISDLRNPALRERH	DNAH2	1301	Q9P225
PPTSARHRLTLRDKT	CFAP74	381	Q9C0B2
RLLSRHISPSLASLR	FTMT	6	Q8N4E7
RESPLHPARELRLHS	PRSS56	436	P0CW18
EELASTHPGRRLRLL	FAM180B	71	Q6P0A1
LHRLAEKSLPPRAES	SPEF2	536	Q9C093
HTLPLSPVQELRRSL	RIN1	596	Q13671
RLRALHLSDLFSPLP	LRRC41	521	Q15345
QLHSLTLRREATEPP	LILRB1	616	Q8NHL6
HLALSRPRRLSTADP	MPIG6B	216	O95866
PEREHLASLIRLTPT	NKX2-2	156	O95096
SPELQLHPRLRSLAV	NPB	71	Q8NG41
LHRSRSFSDLPSLRP	RIPOR2	386	Q9Y4F9
RSLLRREPSERLTAP	TRIB1	316	Q96RU8
REPSERLTAPEILLH	TRIB1	321	Q96RU8
PPRSLARHLSDADRL	TIAM2	1086	Q8IVF5
PSPLRLHRARAEEKS	TBX2	341	Q13207
ARPDLLRSHFIPTLE	RYR3	3206	Q15413
SLVRSRHRIPEPEAA	TRIB3	146	Q96RU7
TVREDPRAHRLLLPS	ROBO3	106	Q96MS0
LRKLHSDLERHPTPR	TKTL2	101	Q9H0I9
LPEPRSRASKIRVHS	NMB	31	P08949
LSRLSPEHRRLRSPA	NAPRT	501	Q6XQN6
LSIRHPEELSLLRAP	FERMT3	131	Q86UX7
DPRLSRDPRLTRHVE	ZC3H4	861	Q9UPT8
PLRLHSRLTSEPERA	PLEKHG7	101	Q6ZR37
FRSTRSLHIPTRDLP	USP34	2701	Q70CQ2
LLDSRALHDPRVSPE	WSCD1	66	Q658N2
RLSSLHKDRPVEPLD	UGT1A6	441	P19224
TAPSRHRLLRVLPNI	ZFAND4	261	Q86XD8
LRHPLRRLEISPDSS	PKP2	141	Q99959
VSSLRDRFPDLPLHI	PC	756	P11498
HSPSPVLNRASLRER	SPATA6	351	Q9NWH7
RPRHLPTRSLEAFAE	TSR3	16	Q9UJK0
LRRHPLPASEAETVL	LRRC26	216	Q2I0M4
LRELSREPHLASSPR	NAALADL1	61	Q9UQQ1
LHSPQLVERLSESRP	NCBP2AS2	11	Q69YL0