Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 THRB ZNF577 HNF4G FEZF2 FEZF1 ZNF678 ZNF850 GFI1 YLPM1 ZNF44	6.62e-08	1412	47	16	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 THRB ZNF577 HNF4G FEZF2 FEZF1 ZNF678 ZNF850 GFI1	6.04e-07	1244	47	14	GO:0000978
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 THRB ZNF577 HNF4G FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	6.77e-07	1459	47	15	GO:0000977
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 THRB ZNF577 HNF4G FEZF2 FEZF1 ZNF678 ZNF850 GFI1	7.81e-07	1271	47	14	GO:0000987
GeneOntologyBiologicalProcess	forebrain anterior/posterior pattern specification	FEZF2 FEZF1	2.91e-05	4	46	2	GO:0021797
Domain	zf-C2H2	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	1.31e-08	693	48	13	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	4.91e-08	775	48	13	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	5.06e-08	777	48	13	PS00028
Domain	Znf_C2H2	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	7.66e-08	805	48	13	IPR007087
Domain	ZnF_C2H2	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	8.00e-08	808	48	13	SM00355
Domain	zf-C2H2_6	ZNF737 ZNF182 ZNF320 ZNF90 FEZF2 FEZF1 ZNF850 GFI1 ZNF44	9.02e-08	314	48	9	PF13912
Domain	-	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF850 GFI1 ZNF44	1.01e-07	679	48	12	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF850 GFI1 ZNF44	1.28e-07	694	48	12	IPR013087
Domain	Znf_C2H2-like	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF850 GFI1 ZNF44	5.59e-07	796	48	12	IPR015880
Domain	KRAB	ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 ZNF850 ZNF44	4.07e-06	369	48	8	SM00349
Domain	KRAB	ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 ZNF850 ZNF44	4.15e-06	370	48	8	IPR001909
Domain	TMEM183	TMEM183BP TMEM183A	6.47e-06	2	48	2	IPR026509
Domain	KRAB	ZNF737 ZNF182 ZNF320 ZNF90 ZNF577 ZNF850 ZNF44	3.36e-05	358	48	7	PS50805
Domain	KRAB	ZNF737 ZNF182 ZNF320 ZNF90 ZNF577 ZNF850 ZNF44	3.36e-05	358	48	7	PF01352
Domain	Gprotein_B	WDR5B GNB5	2.87e-04	10	48	2	IPR001632
Domain	zf-CXXC	CXXC5 MBD1	3.51e-04	11	48	2	PF02008
Domain	Znf_CXXC	CXXC5 MBD1	3.51e-04	11	48	2	IPR002857
Domain	ZF_CXXC	CXXC5 MBD1	3.51e-04	11	48	2	PS51058
Domain	TGFb_propeptide	GDF2 GDF6	2.34e-03	28	48	2	PF00688
Domain	TGF-b_N	GDF2 GDF6	2.34e-03	28	48	2	IPR001111
Domain	TGF-beta-rel	GDF2 GDF6	3.05e-03	32	48	2	IPR015615
Domain	TGFb_CS	GDF2 GDF6	3.05e-03	32	48	2	IPR017948
Domain	TGFB	GDF2 GDF6	4.07e-03	37	48	2	SM00204
Domain	TGF_BETA_2	GDF2 GDF6	4.07e-03	37	48	2	PS51362
Domain	TGF_beta	GDF2 GDF6	4.07e-03	37	48	2	PF00019
Domain	TGF-b_C	GDF2 GDF6	4.07e-03	37	48	2	IPR001839
Domain	TGF_BETA_1	GDF2 GDF6	4.07e-03	37	48	2	PS00250
Domain	zf-C4	THRB HNF4G	6.23e-03	46	48	2	PF00105
Domain	NUCLEAR_REC_DBD_1	THRB HNF4G	6.23e-03	46	48	2	PS00031
Domain	Znf_hrmn_rcpt	THRB HNF4G	6.23e-03	46	48	2	IPR001628
Domain	Nuclear_hrmn_rcpt	THRB HNF4G	6.23e-03	46	48	2	IPR001723
Domain	ZnF_C4	THRB HNF4G	6.23e-03	46	48	2	SM00399
Domain	NUCLEAR_REC_DBD_2	THRB HNF4G	6.23e-03	46	48	2	PS51030
Domain	-	THRB HNF4G	6.49e-03	47	48	2	1.10.565.10
Domain	HOLI	THRB HNF4G	6.77e-03	48	48	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	THRB HNF4G	6.77e-03	48	48	2	IPR000536
Domain	Hormone_recep	THRB HNF4G	6.77e-03	48	48	2	PF00104
Domain	-	THRB HNF4G	9.43e-03	57	48	2	3.30.50.10
Domain	Znf_NHR/GATA	THRB HNF4G	9.76e-03	58	48	2	IPR013088
Domain	-	GDF2 GDF6	1.29e-02	67	48	2	2.10.90.10
Domain	Cystine-knot_cytokine	GDF2 GDF6	1.29e-02	67	48	2	IPR029034
Domain	F-box_dom	TMEM183BP TMEM183A	1.59e-02	75	48	2	IPR001810
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF737 ZNF182 ZNF320 ZNF90 ZNF678 ZNF44	1.87e-07	181	48	6	37372979
Pubmed	Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system.	FEZF2 FEZF1	1.87e-06	2	48	2	24913420
Pubmed	Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex.	FEZF2 FEZF1	1.87e-06	2	48	2	16314561
Pubmed	dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.	FEZF2 FEZF1	1.87e-06	2	48	2	20152183
Pubmed	High bone mass due to novel LRP5 and AMER1 mutations.	LRP5 AMER1	1.87e-06	2	48	2	28893644
Pubmed	Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.	TMEM183BP TMEM183A	1.87e-06	2	48	2	16644869
Pubmed	An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division.	FEZF2 FEZF1	1.87e-06	2	48	2	28245922
Pubmed	Bone Morphogenetic Protein 9 and 13 Induce C3H10T1/2 Cell Differentiation to Cardiomyocyte-Like Cells In Vitro.	GDF2 GDF6	1.87e-06	2	48	2	24380493
Pubmed	Cytoskeletal Stability in the Auditory Organ In Vivo: RhoA Is Dispensable for Wound Healing but Essential for Hair Cell Development.	RHOA GFI1	1.87e-06	2	48	2	28929130
Pubmed	Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.	LRP5 WNT3	5.59e-06	3	48	2	15699046
Pubmed	An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling.	LRP5 WNT3	1.12e-05	4	48	2	18044981
Pubmed	Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.	RHOA LRP5	1.86e-05	5	48	2	36720664
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	RHOA FNBP1 AMER1 NEIL1 MBD1 YLPM1	2.76e-05	431	48	6	33660365
Pubmed	Transgenic mouse models for ADHD.	THRB GNB5	6.67e-05	9	48	2	23681253
Pubmed	Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity.	FEZF2 FEZF1	6.67e-05	9	48	2	21452247
Pubmed	The regulation and deregulation of Wnt signaling by PARK genes in health and disease.	LRP5 WNT3	8.33e-05	10	48	2	24115276
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	CXXC5 MBD1	8.33e-05	10	48	2	29276034
Pubmed	Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W/+ ) mouse model.	LRP5 WNT3	8.33e-05	10	48	2	32822074
Pubmed	Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression.	LRP5 WNT3	1.22e-04	12	48	2	21185284
Pubmed	The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.	FEZF2 FEZF1	1.44e-04	13	48	2	24723342
Pubmed	SAGE reveals expression of Wnt signalling pathway members during mouse prostate development.	RHOA LRP5	1.68e-04	14	48	2	16378759
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF737 ZNF90	2.21e-04	16	48	2	8467795
Pubmed	Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain.	FEZF2 FEZF1	2.21e-04	16	48	2	20431123
Pubmed	Pivotal roles of Fezf2 in differentiation of cone OFF bipolar cells and functional maturation of cone ON bipolar cells in retina.	FEZF2 FEZF1	2.21e-04	16	48	2	29559301
Pubmed	Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.	LRP5 WNT3	2.50e-04	17	48	2	12581525
Pubmed	Regulatory pathway analysis by high-throughput in situ hybridization.	LRP5 SAMD3 WNT3	2.75e-04	91	48	3	17953485
Pubmed	Calcineurin signaling regulates neural induction through antagonizing the BMP pathway.	FEZF2 FEZF1	2.81e-04	18	48	2	24698271
Pubmed	Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.	CXXC5 FEZF2	3.14e-04	19	48	2	37561632
Pubmed	Splicing factor TRA2B is required for neural progenitor survival.	PSIP1 FEZF2	3.14e-04	19	48	2	23818142
Pubmed	Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.	FEZF2 FEZF1	3.49e-04	20	48	2	16971467
Pubmed	The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.	LRP5 WNT3	3.85e-04	21	48	2	15142971
Pubmed	A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.	THRB HNF4G	4.23e-04	22	48	2	23975195
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	LRP5 WNT3	4.23e-04	22	48	2	17064353
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	FEZF2 FEZF1	4.63e-04	23	48	2	20089898
Pubmed	A radial glia-specific role of RhoA in double cortex formation.	RHOA FEZF2	4.63e-04	23	48	2	22405202
Pubmed	Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.	FEZF1 WNT3	4.63e-04	23	48	2	16893423
Pubmed	UPF2 is a critical regulator of liver development, function and regeneration.	TMEM183BP TMEM183A	5.05e-04	24	48	2	20657840
Pubmed	Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.	THRB KCNJ14	5.05e-04	24	48	2	36109497
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	FNBP1 ZNF182 TMEM183BP AMER1 TMEM183A ZFYVE1 GPATCH2L	6.76e-04	1084	48	7	11544199
Pubmed	Molecular architecture of the developing mouse brain.	FEZF2 FEZF1 WNT3	8.16e-04	132	48	3	34321664
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	FNBP1 YLPM1	8.45e-04	31	48	2	19041431
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	CXXC5 FEZF2	8.45e-04	31	48	2	27321927
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF182 ZNF44	8.45e-04	31	48	2	2288909
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CXXC5 FNBP1 LRP5 TMEM183BP AMER1 THRB NEIL1 ZNF44	9.07e-04	1489	48	8	28611215
Pubmed	Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.	FEZF2 FEZF1	1.14e-03	36	48	2	18094027
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	LRP5 WNT3	1.20e-03	37	48	2	15342465
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	LRP5 WNT3	1.20e-03	37	48	2	18800919
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	LRP5 WNT3	1.27e-03	38	48	2	18635608
Pubmed	TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells.	RHOA WNT3	1.34e-03	39	48	2	35781329
Pubmed	Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent.	SAMD3 FEZF2	1.34e-03	39	48	2	30529950
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	ZFYVE1 GPATCH2L YLPM1	1.22e-03	200	48	3	chr14q24
Cytoband	9q34	FNBP1 ABCA2	1.48e-03	54	48	2	9q34
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF711 ZNF737 ZNF182 ZNF320 ZSCAN25 ZNF90 ZNF577 FEZF2 FEZF1 ZNF678 ZNF850 GFI1 ZNF44	1.71e-09	718	39	13	28
GeneFamily	Zinc fingers CXXC-type	CXXC5 MBD1	2.95e-04	12	39	2	136
Disease	breast carcinoma (is_implicated_in)	RHOA THRB	6.38e-04	25	44	2	DOID:3459 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CEYKHRKGSRLGGKR	ERICH3	366	Q5RHP9
TKRKGLAPQRCHRFQ	BTBD6	381	Q96KE9
KKGLKGFFSSIRRHR	AMER1	166	Q5JTC6
KTRRTLKGHGNKVLC	GNB5	96	O14775
RRKRSAGAGSHCQKT	GDF2	316	Q9UK05
QRCIQAKAKRAGKHR	MAML1	61	Q92585
LRIHSKKGRCKAFST	OR8D4	226	Q8NGM9
KKGRRKGRQAASGHC	NEIL1	356	Q96FI4
CGKGFQRKVDLRRHR	GFI1	401	Q99684
HACNKRTGGKRKEIL	LRP5	261	O75197
RCLRGKHARRKGGCD	MBD1	261	Q9UIS9
CRNRKTGHQICKFRK	CXXC5	281	Q7LFL8
NKLRNGHKGLRIFCS	GRB7	306	Q14451
GCKGFFRRSIRKSHV	HNF4G	31	Q14541
GRRRGRFVKKDGHCN	KCNJ14	46	Q9UNX9
TSKPKIHCFRSLKRG	FNBP1	376	Q96RU3
GLLVKRFHCARRNSK	ABCA2	1441	Q9BZC7
RGCRFKSAKKQRLSR	GPATCH2L	156	Q9NWQ4
HRTSKKNKKCRGRLG	LAS2	146	Q8IYD9
GKGFRQASTLCRHKI	FEZF2	311	Q8TBJ5
RHGKRHGKKSRLRCS	GDF6	341	Q6KF10
RAALQARRGKKKSGC	RHOA	176	P61586
KGDHCRGGKKAKQRL	TIGD6	196	Q17RP2
RGKRLKFRAHDACSG	TMEM183BP	21	Q1AE95
KCKFGHRRGQTRKSL	SAMD3	246	Q8N6K7
GKGFCRNFDLKKHVR	FEZF1	406	A0PJY2
SCGHRFLGRSLKQKL	SOCS4	81	Q8WXH5
PSLRRGRKRHCKTKH	RNF169	616	Q8NCN4
RRCKHRTGKADGLTV	IL1R2	371	P27930
KKRKGGRNFQTAHRR	PSIP1	286	O75475
TCFKAKLHRKRGSQP	RSPH3	126	Q86UC2
RGRCLKTYTGHKNEK	WDR5B	241	Q86VZ2
CGKGLRRKKGLSLHQ	ZNF182	211	P17025
GKVFNRCSNLTKHKR	ZNF678	131	Q5SXM1
CGKVFKQRATLAGHR	ZNF320	306	A2RRD8
RGKRLKFRAHDACSG	TMEM183A	21	Q8IXX5
CGKRFSKGERLVRHQ	ZSCAN25	491	Q6NSZ9
KCGKAFSRKCRLNRH	ZNF577	246	Q9BSK1
GCKGFFRRTIQKNLH	THRB	126	P10828
GRGHNTRTEKRKEKC	WNT3	316	P56703
TCGKRNIHGRKLKEI	YLPM1	1966	P49750
LECQKRTHSGGNKRR	ZFYVE1	101	Q9HBF4
ERHGPICKKLFNRKR	ZC2HC1B	31	Q5TFG8
CGKAFRRSLVLRTHK	ZNF90	346	Q03938
GERSKHLKNGCRRGS	SCN7A	891	Q01118
HICTKKFKSRGFLKR	ZNF711	386	Q9Y462
KQCGKLLSHRSSFRR	ZNF44	416	P15621
ECGKAFRRRSKLTQH	ZNF850	901	A8MQ14
CGKAFKRSFILTRHK	ZNF737	486	O75373