Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST4 NDST1 NDST2	1.10e-08	4	29	3	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST4 NDST1 NDST2	1.10e-08	4	29	3	GO:0050119
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST4 NDST1 NDST2	1.24e-06	15	29	3	GO:0034483
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE5A PDE6C PDE6B	4.16e-06	22	29	3	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE5A PDE6C PDE6B	5.46e-06	24	29	3	GO:0047555
GeneOntologyMolecularFunction	heparan sulfate N-deacetylase activity	NDST1 NDST2	6.10e-06	3	29	2	GO:0102140
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE5A PDE6C PDE6B	6.20e-06	25	29	3	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE5A PDE6C PDE6B	7.87e-06	27	29	3	GO:0004112
GeneOntologyMolecularFunction	deacetylase activity	NDST4 NDST1 NDST2	2.62e-05	40	29	3	GO:0019213
GeneOntologyMolecularFunction	sulfotransferase activity	NDST4 NDST1 NDST2	6.87e-05	55	29	3	GO:0008146
GeneOntologyMolecularFunction	protein serine kinase activity	EIF2AK4 RIOK2 MAP3K6 PIM1 MAP3K14	1.60e-04	363	29	5	GO:0106310
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	NDST4 NDST1 NDST2	1.67e-04	74	29	3	GO:0016782
GeneOntologyMolecularFunction	protein kinase activity	EIF2AK4 RET RIOK2 MAP3K6 PIM1 MAP3K14	1.89e-04	600	29	6	GO:0004672
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	NDST4 NDST1 NDST2	2.18e-04	81	29	3	GO:0016811
GeneOntologyMolecularFunction	cGMP binding	PDE5A PDE6C	2.41e-04	16	29	2	GO:0030553
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	EIF2AK4 RET RIOK2 MAP3K6 PIM1 GYS2 MAP3K14	3.10e-04	938	29	7	GO:0016772
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE5A PDE6C PDE6B	3.70e-04	97	29	3	GO:0008081
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	EIF2AK4 RIOK2 MAP3K6 PIM1 MAP3K14	4.15e-04	446	29	5	GO:0004674
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	EIF2AK4 RET RIOK2 MAP3K6 PIM1 MAP3K14	4.63e-04	709	29	6	GO:0016773
GeneOntologyMolecularFunction	kinase activity	EIF2AK4 RET RIOK2 MAP3K6 PIM1 MAP3K14	6.87e-04	764	29	6	GO:0016301
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K6 MAP3K14	6.99e-04	27	29	2	GO:0004709
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	NDST1 PDE5A PTPN12 PDE6C PDE6B NDST2	9.15e-04	807	29	6	GO:0016788
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	NDST4 NDST1 NDST2	1.22e-03	146	29	3	GO:0016810
GeneOntologyMolecularFunction	cyclic nucleotide binding	PDE5A PDE6C	1.46e-03	39	29	2	GO:0030551
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PDE5A PTPN12 PDE6C PDE6B	2.23e-03	386	29	4	GO:0042578
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST4 NDST1 NDST2	1.55e-07	8	30	3	GO:0015014
GeneOntologyBiologicalProcess	heparin biosynthetic process	NDST4 NDST1 NDST2	4.55e-07	11	30	3	GO:0030210
GeneOntologyBiologicalProcess	heparin metabolic process	NDST4 NDST1 NDST2	1.86e-06	17	30	3	GO:0030202
GeneOntologyBiologicalProcess	polysaccharide biosynthetic process	NDST4 NDST1 GYS2 NDST2	4.34e-06	76	30	4	GO:0000271
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process	NDST4 NDST1 NDST2	1.76e-05	35	30	3	GO:0015012
GeneOntologyBiologicalProcess	carbohydrate biosynthetic process	NDST4 NDST1 FUT4 GYS2 NDST2	2.64e-05	247	30	5	GO:0016051
GeneOntologyBiologicalProcess	polysaccharide metabolic process	NDST4 NDST1 GYS2 NDST2	3.22e-05	126	30	4	GO:0005976
GeneOntologyBiologicalProcess	lymphocyte migration into lymphoid organs	RET FUT4	9.14e-05	10	30	2	GO:0097021
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, enzymatic modification	NDST1 NDST2	1.34e-04	12	30	2	GO:0015015
GeneOntologyBiologicalProcess	proteoglycan biosynthetic process	NDST4 NDST1 NDST2	1.42e-04	70	30	3	GO:0030166
GeneOntologyBiologicalProcess	cAMP-mediated signaling	PDE5A PDE6C PDE6B	1.82e-04	76	30	3	GO:0019933
GeneOntologyBiologicalProcess	glycosaminoglycan biosynthetic process	NDST4 NDST1 NDST2	1.82e-04	76	30	3	GO:0006024
GeneOntologyBiologicalProcess	aminoglycan biosynthetic process	NDST4 NDST1 NDST2	2.12e-04	80	30	3	GO:0006023
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan metabolic process	NDST1 NDST2	2.74e-04	17	30	2	GO:0030201
GeneOntologyBiologicalProcess	proteoglycan metabolic process	NDST4 NDST1 NDST2	3.73e-04	97	30	3	GO:0006029
GeneOntologyBiologicalProcess	phototransduction, visible light	PDE6C PDE6B	3.82e-04	20	30	2	GO:0007603
GeneOntologyBiologicalProcess	mucopolysaccharide metabolic process	NDST4 NDST1 NDST2	4.08e-04	100	30	3	GO:1903510
GeneOntologyBiologicalProcess	glycosaminoglycan metabolic process	NDST4 NDST1 NDST2	7.12e-04	121	30	3	GO:0030203
MousePheno	thyroid gland hyperplasia	DUOX2 RET	3.85e-05	5	28	2	MP:0003498
MousePheno	abnormal hepatobiliary system morphology	GREB1L DUOX2 PDE5A EIF2AK4 PTPN12 ITCH PILRA RFX5 GYS2 MAP3K14 DNAH11	6.85e-05	1476	28	11	MP:0002138
Domain	HSNSD	NDST4 NDST1 NDST2	1.49e-08	4	30	3	PF12062
Domain	Heparan_SO4_deacetylase	NDST4 NDST1 NDST2	1.49e-08	4	30	3	IPR021930
Domain	GAF	PDE5A PDE6C PDE6B	1.30e-07	7	30	3	PF01590
Domain	GAF	PDE5A PDE6C PDE6B	2.08e-07	8	30	3	IPR003018
Domain	GAF	PDE5A PDE6C PDE6B	2.08e-07	8	30	3	SM00065
Domain	-	PDE5A PDE6C PDE6B	3.12e-07	9	30	3	3.30.450.40
Domain	GAF_dom-like	PDE5A PDE6C PDE6B	3.12e-07	9	30	3	IPR029016
Domain	PDEase	PDE5A PDE6C PDE6B	3.56e-06	19	30	3	IPR023088
Domain	PDEase_I	PDE5A PDE6C PDE6B	4.88e-06	21	30	3	PF00233
Domain	PDEASE_I	PDE5A PDE6C PDE6B	4.88e-06	21	30	3	PS00126
Domain	PDEase_CS	PDE5A PDE6C PDE6B	4.88e-06	21	30	3	IPR023174
Domain	-	PDE5A PDE6C PDE6B	5.64e-06	22	30	3	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE5A PDE6C PDE6B	6.48e-06	23	30	3	IPR002073
Domain	HDc	PDE5A PDE6C PDE6B	7.40e-06	24	30	3	SM00471
Domain	HD/PDEase_dom	PDE5A PDE6C PDE6B	7.40e-06	24	30	3	IPR003607
Domain	Kinase-like_dom	WDR81 EIF2AK4 RET RIOK2 MAP3K6 PIM1 MAP3K14	1.90e-05	542	30	7	IPR011009
Domain	Sulfotransferase_dom	NDST4 NDST1 NDST2	2.58e-05	36	30	3	IPR000863
Domain	Sulfotransfer_1	NDST4 NDST1 NDST2	2.58e-05	36	30	3	PF00685
Domain	Prot_kinase_dom	EIF2AK4 RET RIOK2 MAP3K6 PIM1 MAP3K14	1.09e-04	489	30	6	IPR000719
Domain	PROTEIN_KINASE_DOM	EIF2AK4 RET RIOK2 MAP3K6 PIM1 MAP3K14	1.14e-04	493	30	6	PS50011
Domain	Protein_kinase_ATP_BS	EIF2AK4 RET MAP3K6 PIM1 MAP3K14	3.14e-04	379	30	5	IPR017441
Domain	PROTEIN_KINASE_ATP	EIF2AK4 RET MAP3K6 PIM1 MAP3K14	7.52e-04	459	30	5	PS00107
Domain	HECT	ITCH WWP1	8.54e-04	27	30	2	PF00632
Domain	HECTc	ITCH WWP1	8.54e-04	27	30	2	SM00119
Domain	HECT_dom	ITCH WWP1	8.54e-04	27	30	2	IPR000569
Domain	HECT	ITCH WWP1	8.54e-04	27	30	2	PS50237
Domain	Ser/Thr_kinase_AS	EIF2AK4 MAP3K6 PIM1 MAP3K14	2.43e-03	357	30	4	IPR008271
Domain	S_TKc	EIF2AK4 MAP3K6 PIM1 MAP3K14	2.48e-03	359	30	4	SM00220
Domain	PROTEIN_KINASE_ST	EIF2AK4 MAP3K6 PIM1 MAP3K14	2.55e-03	362	30	4	PS00108
Domain	WW	ITCH WWP1	2.58e-03	47	30	2	PF00397
Domain	WW	ITCH WWP1	2.69e-03	48	30	2	SM00456
Domain	WW_DOMAIN_2	ITCH WWP1	3.03e-03	51	30	2	PS50020
Domain	WW_DOMAIN_1	ITCH WWP1	3.03e-03	51	30	2	PS01159
Domain	Pkinase	EIF2AK4 MAP3K6 PIM1 MAP3K14	3.07e-03	381	30	4	PF00069
Domain	WW_dom	ITCH WWP1	3.15e-03	52	30	2	IPR001202
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	NDST4 NDST1 NDST2	1.15e-06	11	28	3	M47921
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	NDST4 NDST1 NDST2	1.77e-05	26	28	3	M7330
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST4 NDST1 NDST2	2.48e-05	29	28	3	MM14802
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST4 NDST1 NDST2	3.04e-05	31	28	3	M685
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	NDST4 NDST1 NDST2	7.11e-05	41	28	3	M48095
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ITCH WWP1	1.36e-04	9	28	2	M26930
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ITCH WWP1	1.36e-04	9	28	2	MM14535
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NDST4 NDST1 NDST2	1.63e-04	54	28	3	MM14633
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE5A PDE6C PDE6B	1.72e-04	55	28	3	M39763
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NDST4 NDST1 NDST2	1.91e-04	57	28	3	M692
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	NDST4 NDST1 FUT4 GYS2 NDST2	2.30e-04	288	28	5	M16864
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	NDST4 NDST1 NDST2	1.81e-03	123	28	3	MM14623
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	NDST4 NDST1 FUT4 NDST2	1.90e-03	271	28	4	MM15406
Pathway	REACTOME_SIGNALING_BY_ERBB4	ITCH WWP1	1.93e-03	33	28	2	MM14523
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	NDST4 NDST1 NDST2	1.94e-03	126	28	3	M695
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST4 NDST1 NDST2	2.32e-09	4	30	3	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST4 NDST1 NDST2	2.32e-09	4	30	3	12070138
Pubmed	Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.	PDE5A PDE6C PDE6B	2.32e-09	4	30	3	23033484
Pubmed	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.	NDST4 NDST1 NDST2	5.78e-09	5	30	3	11087757
Pubmed	FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.	NDST4 NDST1 NDST2	3.23e-08	8	30	3	24067353
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST4 NDST1 NDST2	9.51e-08	11	30	3	15944372
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST4 NDST1 NDST2	1.27e-07	12	30	3	12460940
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST4 NDST1 NDST2	6.54e-07	20	30	3	17107998
Pubmed	cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.	NDST1 NDST2	7.19e-07	2	30	2	8144627
Pubmed	Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes.	NDST1 NDST2	7.19e-07	2	30	2	9565617
Pubmed	Cone Phosphodiesterase-6γ' Subunit Augments Cone PDE6 Holoenzyme Assembly and Stability in a Mouse Model Lacking Both Rod and Cone PDE6 Catalytic Subunits.	PDE6C PDE6B	7.19e-07	2	30	2	30038560
Pubmed	N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.	NDST1 NDST2	7.19e-07	2	30	2	23060443
Pubmed	Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.	PDE6C PDE6B	7.19e-07	2	30	2	26085644
Pubmed	Systematic spatiotemporal mapping reveals divergent cell death pathways in three mouse models of hereditary retinal degeneration.	PDE6C PDE6B	7.19e-07	2	30	2	31710697
Pubmed	Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.	NDST1 NDST2	7.19e-07	2	30	2	10758005
Pubmed	Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.	NDST1 NDST2	7.19e-07	2	30	2	12634318
Pubmed	Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.	NDST1 NDST2	7.19e-07	2	30	2	22298785
Pubmed	Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.	NDST1 NDST2	7.19e-07	2	30	2	15319440
Pubmed	Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.	NDST1 NDST2	7.19e-07	2	30	2	16984905
Pubmed	Calcium dynamics change in degenerating cone photoreceptors.	PDE6C PDE6B	7.19e-07	2	30	2	27402880
Pubmed	Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains.	NDST1 NDST2	7.19e-07	2	30	2	18487608
Pubmed	Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3.	PDE5A PDE6C PDE6B	7.62e-07	21	30	3	27740716
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST4 NDST1 NDST2	8.82e-07	22	30	3	19299468
Pubmed	Overview of PDEs and their regulation.	PDE5A PDE6C PDE6B	1.32e-06	25	30	3	17307970
Pubmed	Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.	ITCH WWP1	2.16e-06	3	30	2	12450395
Pubmed	Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis.	NDST1 NDST2	2.16e-06	3	30	2	22345168
Pubmed	Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.	NDST1 NDST2	2.16e-06	3	30	2	18479348
Pubmed	Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.	NDST1 NDST2	2.16e-06	3	30	2	9915799
Pubmed	Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p/RET axis.	ITCH RET	2.16e-06	3	30	2	35091706
Pubmed	Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit.	PDE6C PDE6B	4.31e-06	4	30	2	21799013
Pubmed	Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.	PDE6C PDE6B	4.31e-06	4	30	2	31825309
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	ITCH WWP1	4.31e-06	4	30	2	27466427
Pubmed	Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.	ITCH WWP1	4.31e-06	4	30	2	26701932
Pubmed	Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.	ITCH WWP1	4.31e-06	4	30	2	19580544
Pubmed	Expression patterns of neurturin and its receptor components in developing and degenerative mouse retina.	RET PDE6B	4.31e-06	4	30	2	10067959
Pubmed	Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.	NDST1 NDST2	4.31e-06	4	30	2	16056228
Pubmed	Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.	NDST1 NDST2	4.31e-06	4	30	2	29688404
Pubmed	Heparan sulfate structure in mice with genetically modified heparan sulfate production.	NDST1 NDST2	4.31e-06	4	30	2	15292174
Pubmed	A Tunable Brake for HECT Ubiquitin Ligases.	ITCH WWP1	7.18e-06	5	30	2	28475870
Pubmed	Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.	NDST1 NDST2	7.18e-06	5	30	2	17289920
Pubmed	Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.	ITCH WWP1	1.08e-05	6	30	2	9647693
Pubmed	A mouse model for studying cone photoreceptor pathologies.	PDE6C PDE6B	1.08e-05	6	30	2	25034607
Pubmed	Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.	NDST1 NDST2	1.08e-05	6	30	2	19915053
Pubmed	Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit.	PDE6C PDE6B	1.08e-05	6	30	2	19798052
Pubmed	Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.	ITCH WWP1	1.51e-05	7	30	2	31845480
Pubmed	Altered heparan sulfate structure in mice with deleted NDST3 gene function.	NDST1 NDST2	1.51e-05	7	30	2	18385133
Pubmed	Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate.	NDST1 NDST2	1.51e-05	7	30	2	35608020
Pubmed	Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.	PDE6C PDE6B	1.51e-05	7	30	2	25392995
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	ITCH WWP1	2.01e-05	8	30	2	19307600
Pubmed	Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development.	NDST1 NDST2	2.58e-05	9	30	2	21536023
Pubmed	Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.	PTPN12 RET	2.58e-05	9	30	2	24285539
Pubmed	A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships.	NDST1 NDST2	2.58e-05	9	30	2	30377379
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	ITCH WWP1	3.22e-05	10	30	2	25092867
Pubmed	Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes.	RET PIM1	3.22e-05	10	30	2	7588749
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	ITCH WWP1	3.94e-05	11	30	2	17996703
Pubmed	Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.	ITCH WWP1	3.94e-05	11	30	2	21191027
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	ITCH WWP1	3.94e-05	11	30	2	22773947
Pubmed	Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.	ITCH WWP1	3.94e-05	11	30	2	25963657
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	NDST4 NDST1 NDST2	4.72e-05	81	30	3	39217171
Pubmed	Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.	NDST1 NDST2	4.72e-05	12	30	2	18077586
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	ITCH WWP1	4.72e-05	12	30	2	24107629
Pubmed	Retinal degeneration mutants in the mouse.	PDE6C PDE6B	5.58e-05	13	30	2	11853768
Pubmed	Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.	PDE5A PDE6B	5.58e-05	13	30	2	8557689
Pubmed	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.	ITCH WWP1	6.50e-05	14	30	2	31015455
Pubmed	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.	PDE6C PDE6B	6.50e-05	14	30	2	21297615
Pubmed	In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.	PDE6C PDE6B	6.50e-05	14	30	2	16868010
Pubmed	MAP3Ks as central regulators of cell fate during development.	MAP3K6 MAP3K14	7.50e-05	15	30	2	18855897
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	ITCH WWP1	8.57e-05	16	30	2	25723849
Pubmed	Identification of Greb1l as a genetic determinant of crisscross heart in mice showing torsion of the heart tube by shortage of progenitor cells.	GREB1L CACNA1H	8.57e-05	16	30	2	37852253
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	ITCH WWP1	9.70e-05	17	30	2	28292929
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	ITCH WWP1	1.22e-04	19	30	2	21572392
Pubmed	Identification of novel spartin-interactors shows spartin is a multifunctional protein.	ITCH WWP1	1.22e-04	19	30	2	19765186
Pubmed	Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.	NDST1 NDST2	1.35e-04	20	30	2	24753163
Pubmed	Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development.	NDST1 NDST2	1.35e-04	20	30	2	22745308
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	ITCH WWP1	1.50e-04	21	30	2	37005481
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	ITCH WWP1	1.50e-04	21	30	2	29416926
Pubmed	USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.	ITCH WWP1	1.64e-04	22	30	2	24850914
Pubmed	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	NDST1 NDST2	1.96e-04	24	30	2	34653670
Pubmed	Intracisternal A-type particle elements as genetic markers: detection by repeat element viral element amplified locus-PCR.	PDE6B PIM1	1.96e-04	24	30	2	7873878
Pubmed	The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.	PTPN12 RET PIM1	2.10e-04	134	30	3	24658140
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	ITCH WWP1	2.13e-04	25	30	2	23873930
Pubmed	In silico prediction of physical protein interactions and characterization of interactome orphans.	PTPN12 RET PIM1	2.20e-04	136	30	3	25402006
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	ITCH WWP1	2.31e-04	26	30	2	26949039
Pubmed	The transcription factor c-Maf controls touch receptor development and function.	CACNA1H RET	2.49e-04	27	30	2	22345400
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RET MAP3K6 WWP1 MAP3K14	2.83e-04	372	30	4	22939624
Pubmed	A genetic approach to Mammalian glycan function.	NDST1 NDST2	3.08e-04	30	30	2	12676797
Pubmed	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.	NDST1 NDST2	4.70e-04	37	30	2	32201365
Pubmed	Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.	PDE6C PDE6B	5.23e-04	39	30	2	29922981
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	EIF2AK4 ITCH RIOK2	5.24e-04	183	30	3	31932471
Pubmed	Mouse model resources for vision research.	PDE6C PDE6B	5.78e-04	41	30	2	21052544
Pubmed	Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.	ITCH WWP1	6.06e-04	42	30	2	27578003
Pubmed	Mouse models of ocular diseases.	PDE6C PDE6B	6.65e-04	44	30	2	16332269
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	FUT4 PIM1	7.59e-04	47	30	2	8812413
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZNF106 ITCH MAP3K6 MAP3K14 SEC16A	7.83e-04	861	30	5	36931259
Pubmed	Substrate-trapping techniques in the identification of cellular PTP targets.	PTPN12 RET	8.25e-04	49	30	2	15588985
Interaction	NDST1 interactions	NDST4 NDST1 NDST2	1.73e-05	34	30	3	int:NDST1
Interaction	LDLRAD3 interactions	ITCH WWP1	4.48e-05	7	30	2	int:LDLRAD3
Interaction	NDST4 interactions	NDST4 NDST1	5.96e-05	8	30	2	int:NDST4
Interaction	NDST3 interactions	NDST4 NDST2	7.66e-05	9	30	2	int:NDST3
Interaction	ILDR1 interactions	ITCH WWP1	1.17e-04	11	30	2	int:ILDR1
Interaction	GRB7 interactions	A1BG RET RIOK2 MAP3K14	1.35e-04	178	30	4	int:GRB7
Interaction	WBP1L interactions	ITCH WWP1	1.40e-04	12	30	2	int:WBP1L
Interaction	PDE6C interactions	PDE5A PDE6C	1.93e-04	14	30	2	int:PDE6C
Interaction	PRRG1 interactions	ITCH WWP1	2.22e-04	15	30	2	int:PRRG1
Cytoband	15q15.1	ZNF106 EIF2AK4	4.38e-04	47	30	2	15q15.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4q26	NDST4 PDE5A	6.00e-04	55	30	2	chr4q26
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	ZNF106 EIF2AK4	4.18e-03	147	30	2	chr15q15
GeneFamily	Phosphodiesterases	PDE5A PDE6C PDE6B	4.08e-06	24	24	3	681
GeneFamily	Sulfotransferases, membrane bound	NDST4 NDST1 NDST2	1.55e-05	37	24	3	763
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K6 MAP3K14	4.58e-04	24	24	2	654
Drug	Biperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; MCF7; HT_HG-U133A	GREB1L PDE6C FUT4 PILRA PIM1	5.79e-06	199	30	5	5279_UP
Drug	PDEs	ZNF106 PDE5A PDE6C PDE6B	1.58e-05	116	30	4	CID003036959
Drug	T-0156	PDE5A PDE6B	1.67e-05	5	30	2	CID000005368
Drug	Cyclic GMP	PDE5A PTPN12 PDE6C	4.12e-05	51	30	3	ctd:D006152
Drug	performic acid	PDE5A PDE6C PDE6B	4.37e-05	52	30	3	CID000066051
Drug	2',3'-cAMP	RET PDE6B	4.68e-05	8	30	2	CID000002024
Drug	papaverine	PDE5A CACNA1H PDE6C PDE6B	8.08e-05	176	30	4	CID000004680
Drug	AC1L96WD	PDE5A MAP3K14	9.16e-05	11	30	2	CID000393787
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	PCF11 PTPN12 RET WWP1	1.00e-04	186	30	4	1066_DN
Drug	BAS 012416453; Down 200; 38uM; PC3; HT_HG-U133A	PIM1 MAP3K14 PDZD2 SEC16A	1.18e-04	194	30	4	6876_DN
Drug	Butylparaben [94-26-8]; Up 200; 20.6uM; MCF7; HT_HG-U133A	DUOX2 NDST1 RET FUT4	1.20e-04	195	30	4	5608_UP
Drug	Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A	GREB1L NDST1 CACNA1H NDST2	1.22e-04	196	30	4	1515_UP
Drug	Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A	PTPN12 RET FUT4 NDST2	1.22e-04	196	30	4	7408_UP
Drug	Meclocycline sulfosalicylate [73816-42-9]; Up 200; 5.8uM; MCF7; HT_HG-U133A	CACNA1H FUT4 PDE6B MAP3K6	1.22e-04	196	30	4	3277_UP
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; MCF7; HT_HG-U133A	PCF11 ITCH FUT4 MAP3K14	1.27e-04	198	30	4	5298_DN
Drug	Kaempferol [520-18-3]; Up 200; 14uM; MCF7; HT_HG-U133A	NDST1 FUT4 PDE6B PIM1	1.27e-04	198	30	4	7196_UP
Drug	Clioquinol [130-26-7]; Down 200; 13uM; MCF7; HT_HG-U133A	PDE6C RET FUT4 PDE6B	1.30e-04	199	30	4	5623_DN
Disease	azoospermia (implicated_via_orthology)	NDST4 NDST1 NDST2	2.73e-06	27	30	3	DOID:14227 (implicated_via_orthology)
Disease	primary biliary cholangitis (implicated_via_orthology)	PDE5A MAP3K14	5.99e-06	4	30	2	DOID:12236 (implicated_via_orthology)
Disease	Congenital absence of kidneys syndrome	GREB1L RET	9.97e-06	5	30	2	C1609433
Disease	Unilateral agenesis of kidney	GREB1L RET	2.79e-05	8	30	2	C0266294
Disease	intellectual disability (implicated_via_orthology)	NDST4 NDST1 NDST2	6.09e-05	75	30	3	DOID:1059 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NDST4 NDST1 NDST2	4.91e-04	152	30	3	DOID:0060041 (implicated_via_orthology)
Disease	retinal degeneration (implicated_via_orthology)	PDE6C PDE6B	5.17e-04	33	30	2	DOID:8466 (implicated_via_orthology)
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	ITCH GYS2	1.49e-03	56	30	2	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRLHHENIVRYYNAW	EIF2AK4	641	Q9P2K8
LDWRYLGRYYQHARH	GYS2	596	P54840
RQHIDYGHWYDRQKV	DNAH11	2596	Q96DT5
YAYRWIRNHLEEHTD	RFX5	91	P48382
HYTCRYRLHDNQNGW	A1BG	276	P04217
VSHWDERQARVRYYH	FUT4	361	P22083
QRYDGWFNNLRHHER	DUOX2	36	Q9NRD8
DAGHREQAYHWYRKA	MAP3K6	371	O95382
RRHYCYEQNWPHEST	PDZD2	2316	O15018
YRKNVAYHNWRHAFN	PDE5A	606	O76074
YRRITYHNWRHGFNV	PDE6B	551	P35913
YRAVTYHNWRHGFNV	PDE6C	556	P51160
PADRAYSWYQHQRAH	NDST1	706	P52848
PSDRAYSWYQHQRSH	NDST4	696	Q9H3R1
QSLYYRQWTLARQHH	GREB1L	1281	Q9C091
DVYADHLDWHYRQNR	PCF11	1356	O94913
NDWQRHAIYRHYART	ITCH	791	Q96J02
WRRGHFHRQSFYSTR	PILRA	71	Q9UKJ1
PFREAYNRWHSCYQH	C19orf71	86	A6NCJ1
YREDLHRWNQKRYEA	FAM172A	86	Q8WUF8
AHYRWVRRKYNFDNL	CACNA1H	1476	O95180
YEYREEVHWATHQLR	MAP3K14	391	Q99558
EWIRYHRYHGRSAAV	PIM1	211	P11309
SRRLYQFHYVNWPDH	PTPN12	186	Q05209
IQNTSLIRHWRYYHT	ZFP28	486	Q8NHY6
HWDRYHYSARVRDPR	SEC16A	1271	O15027
ADRAYSWYQHQRAHG	NDST2	706	P52849
YHKHRHNVSWLYLSR	RIOK2	141	Q9BVS4
HLYGTYRTRLHENNW	RET	71	P07949
DWQRNTVYRHYTRNS	WWP1	811	Q9H0M0
YQDRESYSQPAWHHR	ZNF106	111	Q9H2Y7
EVAAQNYRNLWRHAY	WDR81	141	Q562E7
NYRNLWRHAYHTYGQ	WDR81	146	Q562E7
ILRRYSLYTNQHWRH	nan	41	Q8N402