Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphospholipid binding

SPTBN4 DENND1B SNX24 GAS6 CGAS PACSIN3 APOB SMPD3 ZFYVE1 RPH3A MTSS2

8.87e-065487811GO:0005543
GeneOntologyMolecularFunction1-phosphatidylinositol-5-phosphate 4-kinase activity

PIP4K2B PIP4K2C

4.51e-053782GO:0016309
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

DENND1B SNX24 CGAS ZFYVE1 RPH3A MTSS2

1.29e-04199786GO:1901981
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

PLEKHG1 DENND1B MYO9B DENND4B ITSN1 RALGPS2 ARHGEF2 SEC23A MTSS2

1.57e-04507789GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

PLEKHG1 DENND1B MYO9B DENND4B ITSN1 RALGPS2 ARHGEF2 SEC23A MTSS2

1.57e-04507789GO:0030695
GeneOntologyMolecularFunctionsmall GTPase binding

PLEKHG1 EXOC5 DENND1B MYO9B ARHGEF2 RPH3A MTSS2

2.59e-04321787GO:0031267
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

PLEKHG1 DENND1B DENND4B ITSN1 RALGPS2 ARHGEF2

2.88e-04231786GO:0005085
GeneOntologyMolecularFunctionGTPase binding

PLEKHG1 EXOC5 DENND1B MYO9B ARHGEF2 RPH3A MTSS2

5.15e-04360787GO:0051020
GeneOntologyMolecularFunction1-phosphatidylinositol-4-phosphate 5-kinase activity

PIP4K2B PIP4K2C

5.33e-049782GO:0016308
GeneOntologyMolecularFunctionarachidonate-CoA ligase activity

ACSL3 SLC27A6

8.10e-0411782GO:0047676
GeneOntologyMolecularFunctionphosphatidylinositol binding

DENND1B SNX24 CGAS ZFYVE1 RPH3A MTSS2

1.48e-03316786GO:0035091
GeneOntologyMolecularFunctionlong-chain fatty acid-CoA ligase activity

ACSL3 SLC27A6

1.53e-0315782GO:0004467
GeneOntologyMolecularFunctionlipid binding

SPTBN4 DENND1B SNX24 GAS6 CGAS PACSIN3 APOB SMPD3 ZFYVE1 RPH3A MTSS2

1.53e-039887811GO:0008289
DomainPInositol-4-P-5-kinase

PIP4K2B PIP4K2C

3.57e-047782IPR023610
DomainPIPKc

PIP4K2B PIP4K2C

4.74e-048782SM00330
Domain-

PIP4K2B PIP4K2C

4.74e-0487823.30.800.10
DomainPIP5K

PIP4K2B PIP4K2C

4.74e-048782PF01504
DomainPIPK

PIP4K2B PIP4K2C

4.74e-048782PS51455
DomainPInositol-4-P-5-kinase_N

PIP4K2B PIP4K2C

4.74e-048782IPR027484
DomainPInositol-4-P-5-kinase_C

PIP4K2B PIP4K2C

4.74e-048782IPR027483
Domain-

PIP4K2B PIP4K2C

4.74e-0487823.30.810.10
DomainPInositol-4-P-5-kinase_core

PIP4K2B PIP4K2C

4.74e-048782IPR002498
DomainGDS_CDC24_CS

PLEKHG1 ITSN1 ARHGEF2

5.75e-0439783IPR001331
DomainuDENN

DENND1B DENND4B

1.52e-0314782SM00800
DomainuDENN

DENND1B DENND4B

1.75e-0315782PF03456
DomainUDENN

DENND1B DENND4B

1.99e-0316782PS50946
DomainDDENN

DENND1B DENND4B

1.99e-0316782PS50947
DomainDENN

DENND1B DENND4B

1.99e-0316782SM00799
DomaindDENN

DENND1B DENND4B

1.99e-0316782SM00801
DomainDENN

DENND1B DENND4B

1.99e-0316782PF02141
DomaindDENN_dom

DENND1B DENND4B

1.99e-0316782IPR005112
DomainuDENN_dom

DENND1B DENND4B

1.99e-0316782IPR005113
DomaindDENN

DENND1B DENND4B

1.99e-0316782PF03455
DomainDENN

DENND1B DENND4B

1.99e-0316782PS50211
DomainDENN_dom

DENND1B DENND4B

1.99e-0316782IPR001194
DomainDH_1

PLEKHG1 ITSN1 ARHGEF2

2.32e-0363783PS00741
Domainzf-C2H2

HIVEP3 PRDM10 HIVEP2 ZNF337 ZNF584 ZNF451 ZBTB41 ZIC3 ZNF445

2.35e-03693789PF00096
DomainCH

SPTBN4 EHBP1 DMD

2.54e-0365783SM00033
DomainPH

SPTBN4 PLEKHG1 ITSN1 RALGPS2 ARHGEF2

2.71e-03229785PF00169
DomainRhoGEF

PLEKHG1 ITSN1 ARHGEF2

2.89e-0368783SM00325
DomainRhoGEF

PLEKHG1 ITSN1 ARHGEF2

3.14e-0370783PF00621
DomainCH

SPTBN4 EHBP1 DMD

3.14e-0370783PF00307
DomainDH_2

PLEKHG1 ITSN1 ARHGEF2

3.14e-0370783PS50010
DomainDH-domain

PLEKHG1 ITSN1 ARHGEF2

3.27e-0371783IPR000219
Domain-

PLEKHG1 ITSN1 ARHGEF2

3.27e-03717831.20.900.10
Domain-

SPTBN4 EHBP1 DMD

3.27e-03717831.10.418.10
DomainCH

SPTBN4 EHBP1 DMD

3.53e-0373783PS50021
DomainZnf_C2H2_jaz

PRDM10 HIVEP2

3.77e-0322782IPR022755
Domainzf-C2H2_jaz

PRDM10 HIVEP2

3.77e-0322782PF12171
DomainCH-domain

SPTBN4 EHBP1 DMD

3.81e-0375783IPR001715
DomainActinin_actin-bd_CS

SPTBN4 DMD

4.12e-0323782IPR001589
DomainSpectrin

SPTBN4 DMD

4.12e-0323782PF00435
DomainACTININ_2

SPTBN4 DMD

4.12e-0323782PS00020
DomainACTININ_1

SPTBN4 DMD

4.12e-0323782PS00019
DomainSH3_9

ITSN1 PACSIN3 NEB

4.26e-0378783PF14604
DomainCadherin_cytoplasmic-dom

DSG2 CDH12

4.85e-0325782IPR000233
DomainCadherin_C

DSG2 CDH12

4.85e-0325782PF01049
DomainZINC_FINGER_C2H2_2

HIVEP3 PRDM10 HIVEP2 ZNF337 ZNF584 ZNF451 ZBTB41 ZIC3 ZNF445

4.91e-03775789PS50157
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

RPL10A EHBP1 RAD18 DENND1B SNX24 PACSIN3 SMN1 DMD R3HDM1 CDC27 ZFYVE1 SEC23A RPAP2

5.90e-071038791326673895
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CLGN INCENP GAS6 CHEK2 PIP4K2B SRPK1 PIP4K2C ARHGEF2 CDC27 NKAPL STK24 STK25

9.82e-07910791236736316
Pubmed

PI(5)P regulates autophagosome biogenesis.

PIP4K2B PIP4K2C ZFYVE1

1.34e-061079325578879
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RPL10A ACSL3 INCENP MYO9B CGAS SRPK1 RPS24 PRR11 PIP4K2C ARHGEF2 CDC27 SEC23A ZBED5 FTSJ3

1.99e-061353791429467282
Pubmed

Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways.

STK24 STK25

5.09e-06279219855390
Pubmed

The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets.

MYO9B ARHGEF2

5.09e-06279232692911
Pubmed

GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.

STK24 STK25

5.09e-06279235130716
Pubmed

Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.

HIVEP3 HIVEP2

5.09e-06279220404140
Pubmed

Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.

DMD RPL3L

5.09e-06279234081545
Pubmed

Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.

RAD18 CHEK2

5.09e-06279229859927
Pubmed

Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

HIVEP3 HIVEP2

5.09e-0627922247438
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

RAD18 INCENP SMN1 ARHGEF2 CDC27 FTSJ3

8.69e-0621079616565220
Pubmed

Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes.

PIP4K2B PIP4K2C

1.53e-05379230718367
Pubmed

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

MRC1 CHEK2

1.53e-05379211715017
Pubmed

Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration.

GPD2 DMD

1.53e-05379230389681
Pubmed

The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.

PIP4K2B PIP4K2C

1.53e-05379225495341
Pubmed

An ATM-Chk2-INCENP pathway activates the abscission checkpoint.

INCENP CHEK2

1.53e-05379233355621
Pubmed

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

STK24 STK25

1.53e-05379223889253
Pubmed

Dampening of death pathways by schnurri-2 is essential for T-cell development.

HIVEP3 HIVEP2

1.53e-05379221475200
Pubmed

Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.

PIP4K2B PIP4K2C

1.53e-05379223758345
Pubmed

7',5'-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy.

SMN1 DMD

1.53e-05379234850138
Pubmed

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

PIP4K2B PIP4K2C

1.53e-05379226774281
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RPL10A ACSL3 INCENP ATAD2B SRPK1 RPS24 SEC23A HERC5 FTSJ3

1.75e-0565379922586326
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SPTBN4 ACSL3 ARMC3 ITSN1 PIP4K2B ATP11C ZBTB41 APOB DMD ARHGEF2 NEB CDC27 RPL3L

2.09e-051442791335575683
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CEP120 DSG2 ZNF584 ZNF451 DENND4B CGAS PACSIN3 STK25 RPAP2

2.67e-0568979936543142
Pubmed

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

PIP4K2B PIP4K2C

3.05e-0547929367159
Pubmed

Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.

STK24 STK25

3.05e-05479236692953
Pubmed

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

PIP4K2B PIP4K2C

3.05e-05479231091439
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

RAD18 ITSN1 RALGPS2 ZBTB41 APOB RPS24 CDC27 ZFYVE1 STK24 STK25 ZNF445

3.34e-051084791111544199
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

AFF2 RHBDF2 INCENP MYO9B HMGB4 ATP11C ZBTB41 ARHGEF2

3.72e-0555279810737800
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CLGN ZNF451 ITSN1 TOMM34 PIP4K2B PRR11 ARHGEF2 R3HDM1 RPAP2

4.32e-0573379934672954
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

RPL10A EXOC5 INCENP RBM12B MYO9B SRPK1 ARHGEF2 HERC5 FTSJ3

5.64e-0575979935915203
Pubmed

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

RPL10A RBM12B SMN1

7.01e-053579333378683
Pubmed

APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit.

INCENP CDC27

7.60e-05679232934012
Pubmed

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations.

STK24 STK25

7.60e-05679217657516
Pubmed

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

ITSN1 ARHGEF2

7.60e-05679212006984
Pubmed

Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.

STK24 STK25

7.60e-05679234156031
Pubmed

Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.

EHBP1 ACSL3 RHBDF2 DSG2 PRR11

7.69e-0519179531177093
Pubmed

A protein interaction landscape of breast cancer.

RPL10A DSG2 CHEK2 SRPK1 PIP4K2C CDC27 RPAP2 FTSJ3

9.76e-0563479834591612
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

RAD18 TOMM34 SRPK1 CDC27

1.03e-0410679431024071
Pubmed

Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.

PIP4K2B PIP4K2C

1.06e-04779215018809
Pubmed

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

STK24 STK25

1.06e-04779220332113
Pubmed

Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.

DMD NEB

1.06e-04779212176734
Pubmed

Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.

STK24 STK25

1.06e-04779222291017
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

RPL10A GPD2 ACSL3 DSG2 RBM12B MYO9B PACSIN3 ARHGEF2 SEC23A FTSJ3

1.07e-041024791024711643
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

GMNC PLEKHG1 RAD18 METTL24 DENND1B RALGPS2 PACSIN3 SEC23A ZBED5 MTSS2 RPAP2

1.13e-041242791130973865
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

RPL10A INCENP DSG2 RBM12B CGAS PACSIN3 SRPK1 SMN1 RPS24 ARHGEF2 FTSJ3

1.25e-041257791136526897
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RPL10A ACSL3 PLEKHG1 EXOC5 DSG2 ZNF451 ITSN1 TOMM34 SRPK1 PRR11 HERC5 FTSJ3

1.29e-041487791233957083
Pubmed

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.

RPL10A DSG2 TOMM34 SMN1 APOB RPS24 PIP4K2C

1.29e-0449179736273042
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

ACSL3 NKAPL RPL3L STK24 STK25

1.34e-0421579535973513
Pubmed

Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway.

DSG2 DMD

1.41e-04879228826662
Pubmed

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.

ITSN1 PACSIN3

1.41e-04879215719014
Pubmed

Btk-dependent regulation of phosphoinositide synthesis.

PIP4K2B PIP4K2C

1.41e-04879215046600
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

EHBP1 PLEKHG1 HIVEP2 DENND1B DSG2 RALGPS2 ARHGEF2 R3HDM1 MTSS2

1.47e-0486179936931259
Pubmed

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.

RPL10A RAD18 RPS24 CDC27 FTSJ3

1.49e-0422079534091597
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SPTBN4 HIVEP2 ZNF584 ZNF451 ITSN1 RPS24 SMPD3 R3HDM1 RPH3A ZBED5 ZIC3

1.52e-041285791135914814
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

RAD18 PIP4K2B SMN1 PIP4K2C ARHGEF2

1.59e-0422379533187986
Pubmed

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.

RPL10A SRPK1 SMN1 FTSJ3

1.71e-0412179434029587
Pubmed

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.

STK24 STK25

1.82e-04979234518307
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

EXOC5 PIP4K2B ATP11C PIP4K2C CDC27 RPL3L RPAP2

2.14e-0453379725544563
Pubmed

Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.

STK24 STK25

2.27e-041079220949042
Pubmed

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

RPL10A DSG2 ARHGEF2 FTSJ3

2.32e-0413179428031328
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

ACSL3 INCENP TOMM34 SRPK1 RPS24 HERC5 FTSJ3

2.50e-0454779737267103
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

DSG2 ZNF451 PACSIN3 IREB2 SRPK1 SMN1 APOB PRR11 ARHGEF2 SEC23A FTSJ3

2.65e-041371791136244648
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RAD18 CEP120 INCENP DSG2 SNX24 ZNF451 CHEK2 PACSIN3 CDC27 STK25

2.83e-041155791020360068
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

EXOC5 RAD18 SMN1 ARHGEF2 CDC27 STK24 SEC23A

3.63e-0458279720467437
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

EHBP1 DSG2 DENND4B PACSIN3 DMD MTSS2

4.01e-0442179636976175
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

SNX24 PIP4K2B PIP4K2C NEB STK24 STK25

4.59e-0443279623455922
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

RPL10A SMN1 ARHGEF2 CDC27 RPAP2 FTSJ3

5.06e-0444079634244565
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

RPL10A PIP4K2B RPS24 PIP4K2C CDC27 FTSJ3

5.12e-0444179631239290
Pubmed

The DNA sequence and analysis of human chromosome 6.

RPL10A PLEKHG1 HIVEP2 ZNF451 CGAS SRPK1 NKAPL

5.39e-0462279714574404
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

ACSL3 PLEKHG1 RALGPS2 ARHGEF2 R3HDM1 STK24

5.43e-0444679624255178
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

RPL10A GPD2 EHBP1 ACSL3 INCENP RPS24 PRR11 ARHGEF2 R3HDM1 SEC23A FTSJ3

5.53e-041496791132877691
Pubmed

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.

RPL10A GPD2 PIP4K2C RPH3A

5.69e-0416679427160897
Pubmed

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

PRDM10 INCENP RPS24

6.51e-047479329795351
Pubmed

A human MAP kinase interactome.

EHBP1 HIVEP2 ZNF451 ITSN1 DMD NEB

8.48e-0448679620936779
Pubmed

Genes, plasticity and mental retardation.

AFF2 DMD

8.50e-041979218329113
Pubmed

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.

RPL10A DSG2 PACSIN3 SMN1 RPS24

9.22e-0432879523398456
Pubmed

Can we predict top-level sports performance in power vs endurance events? A genetic approach.

DSG2 APOB

9.43e-042079220459474
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

GMNC AFF2 SNX24 ZNF451 RALGPS2 ATP11C R3HDM1

9.56e-0468679729987050
Pubmed

A male germ-cell-specific ribosome controls male fertility.

RPL10A RPS24 RPL3L

9.74e-048579336517592
Pubmed

STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.

RPL10A SPTBN4 ACSL3 FTSJ3

9.79e-0419279432176739
Pubmed

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.

MRC1 APOB

1.04e-032179221943158
Pubmed

The molecular mechanics of eukaryotic translation.

RPL10A RPS24 RPL3L

1.04e-038779315189156
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

RPL10A GPD2 ACSL3 RAD18 DSG2 PACSIN3 TOMM34 RPS24 CDC27 SEC23A

1.04e-031367791032687490
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

RPL10A PACSIN3 RPS24 PIP4K2C STK24 STK25 FTSJ3

1.11e-0370479732994395
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

RPL10A SRPK1 APOB RPS24 NEB STK24

1.12e-0351379625798074
Pubmed

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

SPTBN4 ITSN1

1.14e-032279212812986
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

RPL10A ACSL3 RBM12B SRPK1 SMN1 RPS24 RPL3L

1.20e-0371479728302793
Pubmed

Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.

HIVEP3 ZBTB41

1.25e-032379224925725
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

RPL10A GPD2 PACSIN3 SRPK1 RPS24 PIP4K2C ARHGEF2 SEC23A RPAP2 FTSJ3

1.35e-031415791028515276
Pubmed

Genome-scale RNAi screen for host factors required for HIV replication.

GPD2 PRDM10 SLC27A6 APOB ZBED5

1.41e-0336179518976975
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RPL10A GPD2 ACSL3 INCENP DSG2 RGS22 APOB RPS24 SEC23A FTSJ3

1.43e-031425791030948266
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

RPL10A SPTBN4 GPD2 ITSN1 RPS24 DMD PIP4K2C ARHGEF2 RPH3A SEC23A

1.47e-031431791037142655
Pubmed

Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SPTBN4 HIVEP3 ZFYVE1

1.60e-0310179310997877
Pubmed

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.

RAD18 PIP4K2B SRPK1 PIP4K2C

1.62e-0322079431822558
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PLEKHG1 PRDM10 ATAD2B

1.69e-0310379310574462
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

DMD NEB

1.72e-032779218468998
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

GPD2 ACSL3 EXOC5 PRDM10 CEP120 CDC27

1.75e-0356079635241646
Pubmed

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

RPL10A SNX24 PIP4K2B RPS24 DMD

1.80e-0338279537249651
InteractionKIF23 interactions

RPL10A ACSL3 INCENP DSG2 RBM12B MYO9B ZNF451 PACSIN3 SRPK1 SMN1 RPS24 PRR11 DMD ARHGEF2 STK24 SEC23A HERC5 FTSJ3

7.07e-0810317918int:KIF23
InteractionPAGE1 interactions

CEP120 PIP4K2B DMD PIP4K2C

1.31e-0537794int:PAGE1
InteractionPRKRA interactions

RPL10A PRDM10 CGAS SRPK1 RPS24 PRR11 HERC5 FTSJ3 ZNF445

2.64e-05400799int:PRKRA
Cytoband1q31.3

DENND1B ZBTB41

3.45e-04167921q31.3
CytobandEnsembl 112 genes in cytogenetic band chr5q23

CEP120 SLC27A6 SNX24

1.11e-03117793chr5q23
Cytoband5q23.2

CEP120 SNX24

1.40e-03327925q23.2
Cytoband6p21.31

RPL10A SRPK1

2.30e-03417926p21.31
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

HIVEP3 PRDM10 HIVEP2 ZNF337 ZNF584 ZNF451 ZBTB41 ZIC3 ZNF445

3.81e-0471857928
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SPTBN4 PLEKHG1 ITSN1 RALGPS2 ARHGEF2

4.73e-04206575682
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG1 ITSN1 ARHGEF2

1.18e-0366573722
GeneFamilyProtein phosphatase catalytic subunits|STRIPAK complex

STK24 STK25

1.79e-03205721371
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND1B DENND4B

2.80e-0325572504
GeneFamilyAcyl-CoA synthetase family

ACSL3 SLC27A6

3.02e-032657240
GeneFamilyMethyltransferase like

METTL5 METTL24

4.84e-0333572963
CoexpressionGSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_3H_DN

EHBP1 ACSL3 DENND1B ZNF451 ZBED5 HERC5

2.86e-05196796M6160
CoexpressionGSE36888_UNTREATED_VS_IL2_TREATED_STAT5_AB_KNOCKIN_TCELL_2H_DN

MRC1 HIVEP2 DENND1B GAS6 SMPD3 RPAP2

2.86e-05196796M8757
CoexpressionGSE36009_WT_VS_NLRP10_KO_DC_LPS_STIM_DN

EXOC5 DENND1B ARMC3 MYO9B IREB2 ATP11C

3.11e-05199796M8770
CoexpressionERWIN_COHEN_BLOOD_LIVE_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_14DY_UP

EXOC5 METTL5 CEP120 DENND1B ZNF451 ATP11C ZBTB41 RPS24 SEC23A HERC5

4.05e-056877910M41022
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

EHBP1 ACSL3 HIVEP2 MYO9B ZNF451 ITSN1 ATAD2B DMD R3HDM1 CDC27 STK24

5.04e-058567911M4500
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

GPD2 FBXO25 METTL24 DENND1B AFF2 DSG2 SLC27A6 RGS22 GAS6 TEX15 NKAPL STK24 CDH12 MTSS2 RPAP2

2.29e-078037915gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_500

METTL24 DENND1B AFF2 DSG2 RGS22 GAS6 RALGPS2 TEX15 STK24 MTSS2

2.49e-064047910gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_500
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_k-means-cluster#1_top-relative-expression-ranked_1000

METTL24 DENND1B DSG2 RGS22 NKAPL STK24 CDH12 MTSS2

5.43e-06259798gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_k1_1000
CoexpressionAtlasdev gonad_e11.5_M_GonMes_Sma_k-means-cluster#4_top-relative-expression-ranked_1000

METTL24 DENND1B AFF2 DSG2 STK24 CDH12 MTSS2

2.45e-05231797gudmap_dev gonad_e11.5_M_GonMes_Sma_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_200

METTL24 AFF2 SLC27A6 GAS6 TEX15

1.60e-04137795gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_200
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

METTL24 DENND1B AFF2 DSG2 RGS22 GAS6 RALGPS2 TEX15 STK24 CDH12 MTSS2

1.60e-047917911gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 INCENP SNX24 CHEK2 PRR11 RPH3A

9.06e-07183796e91f00b75d43ee6293fdd4a129b789cd95f8d11a
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLEKHG1 FCRL2 RHBDF2 MYO9B RALGPS2

1.07e-051637956bed27d2f67a430a847da5eb47878d14b4949c45
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHG1 FBXO25 METTL24 MYO9B ZBTB41

1.13e-051657957c771f22b58989572c939ed127e637ec28dc0dca
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RPL10A HTR7 ZNF584 ZNF451 SMN1

1.59e-051777959edfb50856f5e10672ab194ce0076d6a190e64de
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 SNX24 CHEK2 PRR11 RPH3A

1.72e-0518079543fd5c498a87bb078d101298b472656f3294686a
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SPTBN4 PLEKHG1 FCRL2 RALGPS2 NEB

1.86e-0518379501664fce6b70a02c9d39d747b6a6aabc86d57bc2
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMNC RGS22 APOB DMD NEB

1.91e-051847952cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMNC RGS22 APOB DMD NEB

1.91e-05184795ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GMNC RGS22 APOB DMD NEB

1.91e-051847952b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 DMD NEB

2.01e-05186795d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLGN METTL24 INCENP CGAS PRR11

2.23e-05190795b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCellB_cell_maturation-Naive_B_cell|World / Lineage and Cell class

RPL10A PLEKHG1 FCRL2 RHBDF2 RALGPS2

2.34e-0519279558267a11c938a380c6e26f4e4ce63f3b4be79fdc
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

MRC1 ATAD2B GAS6 RPS24 ZNF445

2.46e-0519479558046894446cb250814252a23f60fdd59c114d77
ToppCellHealthy-B_intermediate|Healthy / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 DMD NEB

2.46e-05194795aabee48bf689367edae2079b4b90d253715f1097
ToppCell10x5'v1-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PLEKHG1 FCRL2 RHBDF2 RALGPS2 DMD

2.52e-05195795ecaaa3d071e763c40d05d088fbf9e8ca06f78f47
ToppCellHealthy-B_intermediate|World / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 DMD NEB

2.52e-051957959de79e0bdd9063ae65e5edb89cc3fe6f9a8173bc
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

PLEKHG1 DSG2 TOMM34 ATP11C DMD

2.65e-05197795c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

TYR GMNC ARMC3 DSG2 ATP11C

2.85e-052007955fb90118d3abc28d72bc483e68317255090a04c7
ToppCellLV-03._Atrial_Cardiomyocyte|LV / Chamber and Cluster_Paper

TOMM34 APOB DMD RPH3A

6.20e-051207943b77bd0e3630cdd45001cecf5e47660a90ebc92e
ToppCellCOVID-19-kidney-Mito-rich_Int|kidney / Disease (COVID-19 only), tissue and cell type

SLC27A6 RGS22 DMD CDH12

8.20e-0512979457b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCellControl-Classical_Monocyte-|Classical_Monocyte / Disease condition and Cell class

PRDM10 CLGN HIVEP2 PACSIN3

8.45e-051307944433b40b099845f113993b6ecf85ec594b4b9219
ToppCellTCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-2|TCGA-Bladder / Sample_Type by Project: Shred V9

METTL24 RGS22 DMD NKAPL

1.16e-041417941baa054c2ae3b446d1954244b7fbf8af824ef345
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RPL10A DENND1B AFF2 RPS24

1.26e-041447944f46a22dba047d35076e7768e834b0cbcecc8417
ToppCellHealthy-B_cell|World / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 NEB

1.32e-04146794588359d3df6ad7090b7fa6c7f8d29cc1717e7f4f
ToppCellHealthy-B_cell|Healthy / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 NEB

1.58e-041537947f82cd61b3f1ebaee3e4bbf68ba858a67c2065e7
ToppCell3'_v3-Lung-Lymphocytic_B-Naive_B_cells|Lung / Manually curated celltypes from each tissue

PLEKHG1 FCRL2 RALGPS2 DMD

1.62e-041547942b7d7f09c75bbc22de1358fc44b8ad5d3f656617
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RHBDF2 MYO9B CGAS RPH3A

1.67e-0415579477ae0b8d30bc3db4a73fd5340f99691a73d2684f
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 NEB

1.71e-04156794d81e78bec5c8a3f3ec9e1447ebab2c5805b815eb
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APOB CDC27 RPH3A HERC5

1.71e-04156794f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HTR7 ZNF584 ATAD2B SMN1

1.71e-041567948790b4b400695571fcf1ccb24c658b5e90854ff7
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MRC1 HTR7 GAS6 HERC5

1.79e-04158794216b3f482daa2d0d7fcaf5a8559e3ccbdb8e110d
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 HTR7 GAS6 HERC5

1.79e-041587949712bb8b1bacb8a38c99a22bc2babec5d5160e2a
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

PLEKHG1 FCRL2 RALGPS2 DMD

1.88e-041607946722934e153b72039c3c4308557d0ef879a30638
ToppCell10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

PLEKHG1 FCRL2 RALGPS2 NEB

1.97e-0416279444832055b11a789e320c802aadb345e065defc8f
ToppCellLPS-antiTNF-Myeloid-Dendritic_cells-mDC|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MRC1 DENND1B HTR7 CGAS

2.27e-041687942dca1c4a33b6da9357fa3b2a523af19baab1c21c
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAD18 INCENP SLC27A6 PRR11

2.32e-04169794563c267edaade0e5df192ad953801ef9768d4270
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 FCRL2 RHBDF2 RALGPS2

2.37e-04170794e421f9eedf74baffda1d03707a710ece4b777f29
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CGAS R3HDM1 HERC5 ZNF445

2.37e-0417079407b561cd9c528bc8444c9385e1de621eee7b697e
ToppCellBronchial_Brush-Immune-B_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

FCRL2 ARMC3 RALGPS2 NEB

2.37e-0417079453e9372cb06a2dc5c8ecb3f9af42f3c23da96431
ToppCell3'_v3-blood-Lymphocytic_B-Naive_B_cells|blood / Manually curated celltypes from each tissue

PLEKHG1 FCRL2 ARMC3 RALGPS2

2.48e-04172794f16f90d17feac1ee52fd513907b28456865fd31d
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLEKHG1 FCRL2 RHBDF2 RALGPS2

2.53e-04173794d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL10A RGS22 RPS24 CDH12

2.59e-04174794f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 DMD

2.65e-041757941b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GPD2 FCRL2 RALGPS2 ZBTB41

2.65e-0417579487e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RPL10A HTR7 ZNF451 SMN1

2.70e-04176794dca70f309af24421f8dc708cbd88512814b8e79e
ToppCellControl-Lymphoid-pDC|Control / Condition, Lineage and Cell class

DSG2 GAS6 SMPD3 DMD

2.70e-041767945de16ff65476bde8b23322a44e11412e14f1bafe
ToppCellControl-Myeloid-pDC|Control / Disease group,lineage and cell class (2021.01.30)

DSG2 GAS6 SMPD3 DMD

2.70e-04176794baa3563973ea1a351fe028f55828463d2a51bf1a
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 NEB

2.70e-04176794dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCellCOVID-19_Moderate-B_intermediate|COVID-19_Moderate / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 DMD

2.76e-0417779468e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell10x5'v1-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PLEKHG1 FCRL2 RHBDF2 RALGPS2

2.76e-04177794325c10674b18727ddd50bf088a9c6f4ef29aa809
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GMNC INCENP SNX24 TEX15

2.76e-041777943081ce5fc66a1bb833719d6c0e0a6fc7115eeb91
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DSG2 GAS6 SMPD3 CDH12

2.82e-041787941e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCellmild-Lymphocytic-B_cells_2|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

RPL10A PLEKHG1 FCRL2 RALGPS2

2.82e-04178794c6fb21401ad802a57e4e4f5a1723c42779fdb33e
ToppCellBAL-Severe-Lymphocyte-B-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL10A PLEKHG1 FCRL2 RALGPS2

2.82e-04178794499640cfb1063aa40343ec1563e40fe4645466fb
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPL10A PLEKHG1 FCRL2 RALGPS2

2.82e-04178794851fdcf1451880a048885cc6677b4edfff6aee4c
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPL10A PLEKHG1 FCRL2 RALGPS2

2.82e-041787941a3b3b73e81ceb26cec8153cd1bdd7b446887a71
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAD18 RBM12B CGAS PRR11

2.88e-041797944166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 DSG2 GAS6 TOMM34

2.95e-0418079432d871738a24071b70084a7e80148a516110c78b
ToppCellChildren_(3_yrs)-Immune-B_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 FCRL2 RHBDF2 RALGPS2

2.95e-0418079440a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLEKHG1 DSG2 GAS6 TOMM34

2.95e-04180794067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac|lymph-node_spleen / Manually curated celltypes from each tissue

MRC1 ITSN1 GAS6 PRR11

2.95e-041807944eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-8|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 DMD

3.01e-04181794ca34d83daca10c5fa52ecdf4eba7d31b4e7e056e
ToppCell3'_v3-blood-Myeloid_Dendritic-pDC|blood / Manually curated celltypes from each tissue

DSG2 GAS6 SMPD3 DMD

3.01e-0418179466d890a105f955dca91d6e5e6c730d1a68ee9233
ToppCellnormal_Lung-Myeloid_cells-CD207+CD1a+_LCs|Myeloid_cells / Location, Cell class and cell subclass

PLEKHG1 TOMM34 SMPD3 MTSS2

3.07e-041827948dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCellHippocampus-Neuronal-Inhibitory|Hippocampus / BrainAtlas - Mouse McCarroll V32

HTR7 NEB RPH3A MTSS2

3.07e-04182794b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MRC1 PRDM10 DENND1B MTSS2

3.14e-04183794f142b320023eef00b48d4820c46214c9794d37e7
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MRC1 PRDM10 DENND1B MTSS2

3.27e-04185794e06a784a297f357f3f8e761c24fa70722048ab42
ToppCellCF-Myeloid-cDC|CF / Disease state, Lineage and Cell class

DENND1B HTR7 GAS6 TOMM34

3.27e-041857947f3d118845ff9f5f525796b0bbc6532a8ee323ab
ToppCellcritical-Myeloid-pDC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RPL10A FCRL2 GAS6 SMPD3

3.27e-041857944a5d1d0a757f1f4fdb911be96ed90b52182c25f0
ToppCellURO-Lymphocyte-B|URO / Disease, Lineage and Cell Type

RPL10A PLEKHG1 FCRL2 RALGPS2

3.34e-04186794c46ff4fc280b67a454ee9614e93c6854a5a400b8
ToppCellChildren_(3_yrs)-Immune-B_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.34e-04186794aa576748921a318798b911a611f05319b95e8d5e
ToppCelllymphoid-B_cell-Naive_B_cell|World / Lineage, cell class and subclass

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.40e-04187794904ffd8cf4513e86fcd4c2b7faf24a34fbd2dce3
ToppCellImmune-B_cell|World / Lineage, Cell type, age group and donor

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.40e-04187794795690c6306c366e733279491138d0cd9b469b21
ToppCellLeuk-UTI-Lymphocyte-B|Leuk-UTI / Disease, Lineage and Cell Type

RPL10A PLEKHG1 FCRL2 RALGPS2

3.40e-04187794a16101d427398da286d48241f2dc024e5483597f
ToppCellMonocytes-M2-like_CD16+_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

MRC1 ITSN1 GAS6 NEB

3.40e-0418779459e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCelllymphoid-B_cell|World / Lineage, cell class and subclass

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.40e-041877942abbc01fd7f5b4e52113699625287893c991f8da
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MRC1 RHBDF2 MYO9B ITSN1

3.47e-041887943be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 DMD

3.47e-0418879418d16e3f095a109b6a690f46fe7fcd5674c3636b
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 RHBDF2 MYO9B GAS6

3.47e-04188794cb091912f9b627a78a8793a37df7f1de839f887f
ToppCellHealthy-B_naive|World / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 DMD

3.54e-041897941e533a43f739ff295740cf2b25479756dfb8e595
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC27A6 ATP11C TEX15 RPH3A

3.54e-04189794222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCellwk_15-18-Hematologic_Lymphocytic-B-Immature_B|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.54e-041897945776f842b3047d21ccdc44db884bfd210823c7da
ToppCelllymphoid-B_cell-Naive_B_cell|lymphoid / Lineage, cell class and subclass

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.62e-04190794b8b05894e811e431d797ac4fa3ccff4963a154e7
ToppCelllymphoid-B_cell|lymphoid / Lineage, cell class and subclass

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.62e-04190794c451de643ee08c2ff1093e807c65d724237473c5
ToppCellFetal_29-31_weeks-Immune-B_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.62e-04190794424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCellB_cell_maturation|World / Lineage and Cell class

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.62e-04190794301782283d0c604fb3b428a8ddf1f7cd8e63a90b
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPL10A PLEKHG1 FCRL2 RALGPS2

3.62e-041907941f445f24daf4e0e599ee322835b9223ba0e7a1bd
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 HERC5

3.69e-041917942feab42ac6d29fa4eac78f3f78a5f8aa0a559523
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.69e-04191794a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.69e-0419179403f6da73e7b706252d2096507222229c4101a27b
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.69e-04191794578b58782e816ecaeabfbc616ceb1dcd53ee428b
ToppCellDividing_Macrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

INCENP CHEK2 PRR11 HERC5

3.69e-041917943e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCellFetal_29-31_weeks-Immune-B_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.69e-0419179484452125d1b5b76974e3f9126f611eff16d45c25
ToppCellICU-NoSEP-Lymphocyte-B-B_naive|ICU-NoSEP / Disease, Lineage and Cell Type

RPL10A PLEKHG1 FCRL2 RALGPS2

3.69e-04191794f430961a94890fe8755d22e53836be39cb08e153
ToppCellmetastatic_Brain-B_lymphocytes-Follicular_B_cells|metastatic_Brain / Location, Cell class and cell subclass

RPL10A FCRL2 RALGPS2 RPS24

3.69e-04191794f400fce79aacf029e20b6dca59d3e17bb2375f28
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 FCRL2 RALGPS2 DMD

3.69e-041917945a9a592875fbd0b1429b48db29a760fdc9c2c856
ToppCellILEUM-non-inflamed-(2)_B_cell|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RPL10A FCRL2 RALGPS2 RPS24

3.69e-04191794d4496994dd973eb6d0d8b9101a390af237e12fb2
ToppCellICU-SEP-Lymphocyte-B-B_naive|ICU-SEP / Disease, Lineage and Cell Type

RPL10A PLEKHG1 FCRL2 RALGPS2

3.69e-04191794a090f9ea58a700c995c4ad35eeebb699f07040f7
ToppCellB_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

PLEKHG1 FCRL2 RHBDF2 RALGPS2

3.69e-0419179472e3191990973440e4f91427208df360f73e4f41
ToppCellCOVID-19_Severe-B_intermediate|World / disease group, cell group and cell class

PLEKHG1 FCRL2 RALGPS2 DMD

3.69e-04191794f226fd69a26124ba98e4544f550b89a08e6a3708
DiseasePROSTATE CANCER, HEREDITARY, 1

INCENP MYO9B DENND4B CHEK2

1.87e-0560774C4722327
DiseaseProstate cancer, familial

INCENP MYO9B DENND4B CHEK2

3.26e-0569774C2931456
Diseaseobsolete_red blood cell distribution width

EHBP1 PLEKHG1 DENND1B SLC27A6 MYO9B ITSN1 ATAD2B GAS6 CHEK2 ATP11C APOB R3HDM1 ZFYVE1

4.25e-0513477713EFO_0005192
Diseaseendometriosis, unipolar depression

TYR HIVEP2 DENND1B

1.96e-0443773EFO_0001065, EFO_0003761
Diseasecoronary artery disease

EHBP1 PLEKHG1 HIVEP2 CEP120 DENND1B SLC27A6 MYO9B PIP4K2B APOB STK24 RPH3A

2.63e-0411947711EFO_0001645
Diseasecerebral cavernous malformation (implicated_via_orthology)

STK24 STK25

3.64e-0411772DOID:0060669 (implicated_via_orthology)
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

HIVEP3 HIVEP2

5.15e-0413772DOID:0050787 (implicated_via_orthology)
Diseasepulse pressure measurement

SPTBN4 HIVEP3 PLEKHG1 CLGN CEP120 DENND1B ATAD2B RALGPS2 ZBTB41 RPH3A STK25

9.45e-0413927711EFO_0005763
Diseaseanorectal malformation

HMGB4 GAS6

1.12e-0319772MONDO_0019938
Diseasemean reticulocyte volume

MYO9B ITSN1 ATAD2B GAS6 CHEK2 SRPK1 NEB RPH3A

1.13e-03799778EFO_0010701
Diseaseinfluenza A (H1N1)

ACSL3 ATAD2B DMD

1.55e-0387773EFO_1001488
Diseasecerebellum cortex volume change measurement, age at assessment

HIVEP2 STK24

2.10e-0326772EFO_0008007, EFO_0021497
Diseasewellbeing measurement

TYR EHBP1 HIVEP2 DENND1B ATAD2B TEX15 STK24

2.20e-03692777EFO_0007869
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

EHBP1 GAS6 APOB

2.24e-0399773EFO_0004611, EFO_0007878
Diseasegastroesophageal reflux disease

HIVEP2 APOB STK24

2.37e-03101773EFO_0003948
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

EHBP1 GAS6 APOB

2.44e-03102773EFO_0004329, EFO_0004611
Diseasecomplement factor H-related protein 2 measurement

DENND1B ZBTB41

2.61e-0329772EFO_0600055

Protein segments in the cluster

PeptideGeneStartEntry
FKLKKDHAMKYSRSL

AFF2

1171

P51816
FCSRHSKALKLYKEL

ARHGEF2

341

Q92974
RSSKEKNKKNSYHFS

ARMC3

636

Q5W041
LKNKFRTKRYFAKHP

DMD

3376

P11532
KRTDKYRTYSKKHFR

CHEK2

131

O96017
DKKHLDKFSSYHVKT

CGAS

426

Q8N884
VNKFKLRTSKKHYDF

R3HDM1

1076

Q15032
FKTLKDYNTALSLHK

RBM12B

331

Q8IXT5
DEIHSKYRKKHKSEF

RAD18

336

Q9NS91
SHKKFFDVSKLGTKY

IREB2

21

P48200
NKAAFHKSIRSKYKP

DSG2

356

Q14126
DRYKKRFHKFDADQK

GPD2

626

P43304
FKKSKPRYHKRTSSA

INCENP

881

Q9NQS7
KIDKHNYLTAKDFLK

ATAD2B

1011

Q9ULI0
AKEYKRARHEIKKKS

MTSS2

126

Q765P7
EYASKKRKKDHFRND

FBXO25

61

Q8TCJ0
YCDKVYKSASKRKAH

PRDM10

776

Q9NQV6
YKSASKRKAHILKNH

PRDM10

781

Q9NQV6
SKLLYKASVVKKAAA

SMPD3

321

Q9NY59
LKIESKKHKAYLRSA

HERC5

651

Q9UII4
LPASYKFHKKKSVDI

METTL5

186

Q9NRN9
DRFSEVKSKIASKYH

EXOC5

176

O00471
SHAKEKLTALTKKYR

APOB

2136

P04114
ERKLESATKSKLHYK

CEP120

831

Q8N960
SVALVDYHSTKKLKK

GAS6

536

Q14393
RKFLHSGKLYKAKSN

ITSN1

1461

Q15811
YSYSRDLDLAKKKHA

EHBP1

766

Q8NDI1
FDKKYKSAFNKLASS

DENND4B

1451

O75064
IKKYYHISSSAEKKI

LAMB4

1311

A4D0S4
KKAYTFKVEASNLHL

CDH12

341

P55289
YHKDNKELSVFKKFS

FCRL2

51

Q96LA5
TAYKFAKNHAKLGLK

DENND1B

446

Q6P3S1
KFHRASVLFANEKYK

CDC27

706

P30260
EASKKSYHAARKDEK

PACSIN3

151

Q9UKS6
LTQYDAKKKAAHAAK

PIP4K2C

376

Q8TBX8
YAAKSLKATERKHFK

RALGPS2

496

Q86X27
TSLCFKLYAKGKHEK

MRC1

656

P22897
QKDFRLFHSYKDLSK

METTL24

326

Q5JXM2
FFYDIKHSDLAKKSL

RPH3A

621

Q9Y2J0
KAKKLLSSDEFSKAY

GMNC

126

A6NCL1
RRFYKDWHKSKKKAF

RPL3L

116

Q92901
YFRKLQALHKETFSK

RGS22

801

Q8NE09
LKHKFILRNAKKTSY

STK24

281

Q9Y6E0
SISKHEKAKYEALAK

HMGB4

51

Q8WW32
LTPYDTKKKAAHAAK

PIP4K2B

371

P78356
KVGKSRRDKFYHLAK

FTSJ3

6

Q8IY81
KAYDKAVASFKHALK

SMN1

41

Q16637
YSKEFFTKKGDLKHI

SRPK1

586

Q96SB4
AKELLKHKFITRYTK

STK25

261

O00506
AKYVKKGTKHFEALA

SEC23A

321

Q15436
QIYKAARKSAAKHKF

HTR7

261

P34969
DAFKLKRKELKTHYQ

ACSL3

696

O95573
DLKKFFTDRKTHLYT

CLGN

216

O14967
RNSDYSVPKFKHLKK

ATP11C

846

Q8NB49
NKSSKRKHRKYSDSD

NKAPL

191

Q5M9Q1
GKSFKAKYKLVNHIR

ZIC3

306

O60481
HKALKDYKSSFADIS

TOMM34

271

Q15785
YKFTASASHTERKLK

ZNF451

831

Q9Y4E5
EKRYSEFHALHKKLK

SNX24

36

Q9Y343
KKSAEHFKRKFAKSN

RPAP2

331

Q8IXW5
YSKVKEAFSKKHQRK

TSSK3

21

Q96PN8
ATFKRKDKLKYHIDH

ZBTB41

731

Q5SVQ8
LARHGLYEKKKTSRK

RPS24

91

P62847
GFSFKTKSNLYKHRK

HIVEP3

226

Q5T1R4
KDKFFAYLTLAKHTI

TYR

131

P14679
TSEVASDYKKKKHVF

SPTBN4

2481

Q9H254
KKLAKKYDAFLASES

RPL10A

101

P62906
AYLKHFTKELKATTA

ZFYVE1

286

Q9HBF4
KHAAYKDKDISFFKQ

ZBED5

156

Q49AG3
KDFAYRSAFIVHKKK

ZNF445

716

P59923
TKKRDDTFTYKAHIL

PLEKHG1

351

Q9ULL1
LKKPASYVSDFKEKH

TEX15

1591

Q9BXT5
YKHTKDKLLCDVFKK

SLC27A6

441

Q9Y2P4
FKTKSNLYKHRKSHA

HIVEP2

226

P31629
KRIASKVKHFAFDRK

RHBDF2

351

Q6PJF5
KVKHFAFDRKKRHYG

RHBDF2

356

Q6PJF5
ERLFKKKEASHFQSK

PRR11

16

Q96HE9
KAFSYPSKLRKHQKV

ZNF584

221

Q8IVC4
KFSNKSYYSKHLKRH

ZNF337

721

Q9Y3M9
FKRLFLHKTKDKKYS

MYO9B

1416

Q13459
KHAADIFSEKKYRTK

NEB

4136

P20929