Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	SCNN1B NIPAL2 SLC37A3 SLC44A5 SLC34A1 MFSD1 SV2A CATSPER4 MFSD10 SLC5A2	1.29e-04	1180	42	10	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SCNN1B NIPAL2 SLC37A3 SLC44A5 SLC34A1 MFSD1 SV2A CATSPER4 MFSD10 SLC5A2	2.66e-04	1289	42	10	GO:0005215
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC37A3 SLC44A5 SLC34A1 MFSD1 SLC5A2	3.76e-04	296	42	5	GO:0015291
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT12 GALNT1	8.01e-04	20	42	2	GO:0004653
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC37A3 SLC34A1	1.16e-03	24	42	2	GO:0005315
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNT12 GALNT1	2.46e-03	35	42	2	GO:0008376
GeneOntologyBiologicalProcess	sodium ion import across plasma membrane	SCNN1B SLC34A1 SLC5A2	1.91e-05	27	40	3	GO:0098719
GeneOntologyCellularComponent	brush border	VIL1 SLC34A1 TREH MFSD10 SLC5A2	1.30e-05	152	42	5	GO:0005903
GeneOntologyCellularComponent	cluster of actin-based cell projections	VIL1 SLC34A1 TREH MFSD10 SLC5A2	8.15e-05	223	42	5	GO:0098862
GeneOntologyCellularComponent	brush border membrane	SLC34A1 MFSD10 SLC5A2	6.20e-04	83	42	3	GO:0031526
GeneOntologyCellularComponent	filopodium tip	VIL1 ABI2	7.32e-04	20	42	2	GO:0032433
Domain	MFS	SLC37A3 MFSD1 SV2A MFSD10	2.65e-05	77	42	4	IPR011701
Domain	MFS_1	SLC37A3 MFSD1 SV2A MFSD10	2.65e-05	77	42	4	PF07690
Domain	MFS	SLC37A3 MFSD1 SV2A MFSD10	9.99e-05	108	42	4	PS50850
Domain	MFS_dom	SLC37A3 MFSD1 SV2A MFSD10	2.30e-04	134	42	4	IPR020846
Domain	Ricin_B_lectin	GALNT12 GALNT1	1.43e-03	25	42	2	PF00652
Domain	RICIN	GALNT12 GALNT1	1.80e-03	28	42	2	SM00458
Domain	RICIN_B_LECTIN	GALNT12 GALNT1	1.80e-03	28	42	2	PS50231
Domain	Glyco_trans_2-like	GALNT12 GALNT1	2.06e-03	30	42	2	IPR001173
Domain	Ricin_B_lectin	GALNT12 GALNT1	2.06e-03	30	42	2	IPR000772
Domain	Glycos_transf_2	GALNT12 GALNT1	2.06e-03	30	42	2	PF00535
Domain	-	ABHD4 CES4A LIPH	2.42e-03	119	42	3	3.40.50.1820
Domain	AB_hydrolase	ABHD4 CES4A LIPH	2.42e-03	119	42	3	IPR029058
Domain	WD40_repeat_dom	VPS11 MLST8 WDFY2 WDR46	4.36e-03	297	42	4	IPR017986
Domain	-	VPS11 MLST8 WDFY2 WDR46	6.52e-03	333	42	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	VPS11 MLST8 WDFY2 WDR46	6.65e-03	335	42	4	IPR015943
Pubmed	Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial isocitrate dehydrogenase (IDHM) to the q11 leads to qter region of chromosome 15 in man.	IDH2 MAN2C1	1.42e-06	2	42	2	752528
Pubmed	Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation.	NOD1 CRLF2	1.42e-05	5	42	2	21856952
Pubmed	Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.	SCNN1B SLC34A1 SLC5A2	2.56e-05	47	42	3	28527294
Pubmed	EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.	EMILIN3 NID1	3.97e-05	8	42	2	32948785
Pubmed	Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney.	SLC34A1 SLC5A2	3.97e-05	8	42	2	26279573
Pubmed	Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion.	PTPA MLST8	3.97e-05	8	42	2	19553685
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ELAVL1 TGM3 IDH2 MDH1 ERO1A DYNC1H1 AQR SLC5A2 WDR46	4.16e-05	1425	42	9	30948266
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	RARS2 NOD1 IDH2 MDH1 DYNC1H1	4.83e-05	331	42	5	29199018
Pubmed	Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.	SLC37A3 MFSD1	5.10e-05	9	42	2	21752829
Pubmed	USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle formation.	PTPA DYNC1H1	9.32e-05	12	42	2	29293652
Pubmed	Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling.	SCNN1B SLC34A1	1.69e-04	16	42	2	21354128
Pubmed	Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.	SLC34A1 SLC5A2	2.15e-04	18	42	2	28334964
Pubmed	Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.	VIL1 MDH1 SLC34A1	2.30e-04	98	42	3	9507200
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT12 GALNT1	3.24e-04	22	42	2	25107907
Pubmed	Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.	ELAVL1 MLST8 DYNC1H1	3.32e-04	111	42	3	21163940
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ABHD4 NEK4 ELAVL1 NID1 HACE1	3.71e-04	513	42	5	25798074
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT12 GALNT1	3.86e-04	24	42	2	31740596
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT12 GALNT1	3.86e-04	24	42	2	31882545
Pubmed	Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.	SCNN1B SLC34A1	3.86e-04	24	42	2	17079272
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ELAVL1 PTPA IDH2 MDH1 DYNC1H1 MVD	3.94e-04	807	42	6	30575818
Pubmed	Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney.	VIL1 SLC34A1	4.54e-04	26	42	2	20944551
Pubmed	PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.	NID1 ABI2	4.54e-04	26	42	2	32673396
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	TGM3 IDH2 MLST8 DYNC1H1	5.44e-04	312	42	4	37120454
Pubmed	Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.	VPS11 ERO1A	6.06e-04	30	42	2	32645484
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	VPS11 MLST8	7.34e-04	33	42	2	33452816
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT12 GALNT1	8.74e-04	36	42	2	25615642
Pubmed	Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system.	TM4SF1 SLC34A1	9.74e-04	38	42	2	18407958
Pubmed	Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation.	VIL1 SLC34A1	1.03e-03	39	42	2	18346943
Pubmed	O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.	GALNT12 GALNT1	1.08e-03	40	42	2	22643896
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ELAVL1 TGM3 DYNC1H1 AQR WDR46	1.10e-03	653	42	5	22586326
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT12 GALNT1	4.64e-04	20	29	2	433
GeneFamily	Solute carriers	SLC37A3 SLC44A5 SLC34A1 SLC5A2	3.46e-03	395	29	4	752
GeneFamily	WD repeat domain containing	MLST8 WDFY2 WDR46	8.32e-03	262	29	3	362
ToppCell	mLN-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	NIPAL2 ABI2 MFSD1 WDR46	2.41e-06	100	42	4	c560326f6ae5338aecdf11ef8adf04bc8769745c
ToppCell	facs-Kidney-nan-24m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 TREH	1.79e-05	166	42	4	fe87b444fc0ef6fc20c646c9d2c3c8ce916a70c0
ToppCell	droplet-Kidney-nan-21m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 SLC5A2	2.46e-05	180	42	4	2b2c656d6620afa32555f14aad94ac56e71e360c
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_straight_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDH1 SLC34A1 MFSD1 SLC5A2	2.46e-05	180	42	4	b34d933cdabf692f02eaaf65c2aaca1fb9510627
ToppCell	droplet-Kidney\|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 SLC5A2	2.46e-05	180	42	4	7e5f497699876ac8e1ce780626c6f5a1f6f5f079
ToppCell	droplet-Kidney-nan-18m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 SLC5A2	2.46e-05	180	42	4	cd743f81838ba210e5bb63fe0870918d7d2b0112
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SCNN1B SLC44A5 TM4SF1 LIPH	2.57e-05	182	42	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	droplet-Kidney-nan-21m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 SLC5A2	2.57e-05	182	42	4	942c18a27b22fb33a5200d5717cad972f3ef0576
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 SLC5A2	2.80e-05	186	42	4	fa5f602f01de5beec529d9f5208172b2914a952d
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 MDH1 SLC34A1 SLC5A2	2.92e-05	188	42	4	c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIL1 MDH1 SLC34A1 SLC5A2	2.92e-05	188	42	4	b483b4629695764568bcbd1d527d614824147783
ToppCell	droplet-Kidney-nan-3m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDH2 MDH1 SLC34A1 SLC5A2	2.92e-05	188	42	4	6b185d0aaeea64f9ae584a9bcb9741658bb1c7bd
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SCNN1B SLC44A5 TM4SF1 LIPH	3.30e-05	194	42	4	a58841b34efe673671a9a059238e044a7254b279
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SCNN1B SLC44A5 TM4SF1 LIPH	3.30e-05	194	42	4	0cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 MDH1 SLC34A1 SLC5A2	3.57e-05	198	42	4	64d73804902a043bdf66b413b769e853d111c033
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 MDH1 SLC34A1 SLC5A2	3.57e-05	198	42	4	7db113a6e7962ff26c1e1a43baa1a4230cf5f393
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIL1 MDH1 SLC34A1 SLC5A2	3.57e-05	198	42	4	8777117249077d4964dd7566aebde7c443475c7e
Drug	alpha-methyl-D-mannoside	VPS11 IDH2 MAN2C1 TREH SLC5A2	2.30e-06	116	42	5	CID000002108
Drug	glucose-6-P	VPS11 IDH2 MAN2C1 MDH1 SLC34A1 SV2A TREH	4.35e-06	366	42	7	CID000000208
Disease	nephrolithiasis	SCNN1B SLC34A1	9.21e-04	33	40	2	EFO_0004253

Protein segments in the cluster

Peptide	Gene	Start	Entry
WGGTQEDRMGFGGAV	CATSPER4	21	Q7RTX7
GFGGGVGLWILNMDS	ABHD4	76	Q8TB40
QSEYGGVVFGGWARM	AQR	496	O60306
DGWYEGVMNGVTGLF	ABI2	486	Q9NYB9
GGVDWFATAIGMPVE	MFSD10	66	Q14728
DIWFGTPEGEFVSMG	MDH1	256	P40925
VGFHEDGRWMYTGGE	MLST8	91	Q9BVC4
SWEGGDGLLYIVMGF	NEK4	71	P51957
GGIIGWMFAVEQDGF	NID1	491	P14543
MVWFPGGAFIVGAAS	CES4A	136	Q5XG92
FHGEEGMGQGVVREW	HACE1	586	Q8IYU2
EVGMWGNQVGDEGAK	NOD1	816	Q9Y239
GFVEWQMGEQADGKD	MVD	166	P53602
FWLMEFGRFVFGIGG	MFSD1	136	Q9H3U5
GAHISGFVGEMYDGW	LIPH	156	Q8WWY8
GFVGEMYDGWLGRIT	LIPH	161	Q8WWY8
DEGILWQMFGPFGAV	ELAVL1	256	Q15717
AVFLLGGWMALGQGG	CRLF2	11	Q9HC73
AGWQVMVGVGTPFGA	SLC34A1	536	Q06495
IGTYDAGMDIWGGEN	GALNT1	306	Q10472
EWEVYNFPAGGVGMG	IDH2	206	P48735
GMEVWGGENLEFSFR	GALNT12	331	Q8IXK2
MGRGWGFLFGLLGAV	ERO1A	1	Q96HE7
FVPVGGTWVEMDGNL	MAN2C1	326	Q9NTJ4
ILFGMVGAYDWGGSV	ITGA10	386	O75578
GFRLMERAHGGGFVW	INPP5B	211	P32019
LTYGDGEEVGGMWVE	DYNC1H1	2191	Q14204
FWVFMIGVIGIIGYG	SLC44A5	271	Q8NCS7
WGVGGFGTMLEERVQ	EMILIN3	461	Q9NT22
NLGGQFGFWMGGSVL	SCNN1B	521	P51168
LGDWGMQFGLLGTGF	RARS2	171	Q5T160
WGGVLLMAVGETGNF	NIPAL2	91	Q9H841
MVGAFLWGGLADRLG	SV2A	216	Q7L0J3
IGMIGWNFGQFEEDI	TGM3	171	Q08188
VEGQEPANFWMALGG	VIL1	586	P09327
RGSLVFGDMEGQIWF	VPS11	56	Q9H270
GGDGGIVVWNMDVER	WDFY2	261	Q96P53
MGNWFGKAGRGVVFG	SLC37A3	166	Q8NCC5
NEQGAFWGLIGGLLM	SLC5A2	481	P31639
MEPAGSQGVWGLDDF	PTPA	236	Q15257
EVQEGFGWTNGVVLM	TREH	531	O43280
VAGMGDVVNIWAGQG	WDR46	416	O15213
FVWFFSGIVGGGLLM	TM4SF1	46	P30408