Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessdevelopment of secondary male sexual characteristics

STAT5A STAT5B

2.17e-053562GO:0046544
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation

PGLYRP2 STAT5A STAT5B

2.44e-0521563GO:0032823
GeneOntologyBiologicalProcessmitotic cell cycle

TTLL12 CCNF SETDB2 RNF40 XPC XRCC3 ANKFN1 STAT5A STAT5B SPICE1 PCNT

7.46e-0510145611GO:0000278
GeneOntologyBiologicalProcessnatural killer cell differentiation

PGLYRP2 STAT5A STAT5B

1.49e-0438563GO:0001779
GeneOntologyBiologicalProcesstaurine metabolic process

STAT5A STAT5B

2.57e-049562GO:0019530
GeneOntologyBiologicalProcesspyrimidine dimer repair

POLH XPC

2.57e-049562GO:0006290
GeneOntologyBiologicalProcessalkanesulfonate metabolic process

STAT5A STAT5B

2.57e-049562GO:0019694
GeneOntologyBiologicalProcessT cell differentiation in thymus

ERBB2 STAT5A STAT5B SOS1

2.60e-04114564GO:0033077
GeneOntologyBiologicalProcessSchwann cell development

SLC25A46 ERBB2 SOS1

2.82e-0447563GO:0014044
GeneOntologyBiologicalProcesscerebellar cortex morphogenesis

SLC25A46 AGTPBP1 PCNT

3.01e-0448563GO:0021696
GeneOntologyBiologicalProcessgrowth hormone receptor signaling pathway via JAK-STAT

STAT5A STAT5B

3.21e-0410562GO:0060397
GeneOntologyBiologicalProcessdevelopment of secondary female sexual characteristics

STAT5A STAT5B

3.21e-0410562GO:0046543
GeneOntologyBiologicalProcessbody fluid secretion

ALOX12B WNK3 STAT5A STAT5B

3.27e-04121564GO:0007589
GeneOntologyBiologicalProcessregulation of centrosome duplication

CCNF XRCC3 SPICE1

3.81e-0452563GO:0010824
GeneOntologyBiologicalProcessnegative regulation of erythrocyte differentiation

STAT5A STAT5B

3.92e-0411562GO:0045647
GeneOntologyBiologicalProcessresponse to interleukin-2

STAT5A STAT5B

3.92e-0411562GO:0070669
GeneOntologyBiologicalProcessSchwann cell differentiation

SLC25A46 ERBB2 SOS1

4.50e-0455563GO:0014037
GeneOntologyBiologicalProcesserror-prone translesion synthesis

POLH REV3L

4.70e-0412562GO:0042276
GeneOntologyBiologicalProcesspositive regulation of gamma-delta T cell differentiation

STAT5A STAT5B

4.70e-0412562GO:0045588
GeneOntologyBiologicalProcesspositive regulation of natural killer cell differentiation

STAT5A STAT5B

4.70e-0412562GO:0032825
GeneOntologyBiologicalProcessresponse to interleukin-15

STAT5A STAT5B

4.70e-0412562GO:0070672
GeneOntologyBiologicalProcessmicrotubule-based process

CCNF TCTE1 ERBB2 KIF27 SIK3 XRCC3 ANKFN1 AGTPBP1 SPICE1 PCNT

4.99e-0410585610GO:0007017
GeneOntologyBiologicalProcessmucosa-associated lymphoid tissue development

STAT5A STAT5B

5.54e-0413562GO:0048537
GeneOntologyBiologicalProcessPeyer's patch development

STAT5A STAT5B

5.54e-0413562GO:0048541
GeneOntologyBiologicalProcessdevelopment of secondary sexual characteristics

STAT5A STAT5B

5.54e-0413562GO:0045136
GeneOntologyBiologicalProcessERBB2-ERBB3 signaling pathway

ERBB2 SOS1

5.54e-0413562GO:0038133
GeneOntologyBiologicalProcessmulticellular organism growth

SIK3 STAT5A STAT5B PCNT SOS1

5.70e-04249565GO:0035264
GeneOntologyBiologicalProcesscerebellum morphogenesis

SLC25A46 AGTPBP1 PCNT

5.81e-0460563GO:0021587
GeneOntologyBiologicalProcessregulation of natural killer cell activation

PGLYRP2 STAT5A STAT5B

6.10e-0461563GO:0032814
GeneOntologyBiologicalProcesspositive regulation of gamma-delta T cell activation

STAT5A STAT5B

6.45e-0414562GO:0046645
GeneOntologyBiologicalProcessERBB3 signaling pathway

ERBB2 SOS1

6.45e-0414562GO:0038129
GeneOntologyBiologicalProcessregulation of centrosome cycle

CCNF XRCC3 SPICE1

6.71e-0463563GO:0046605
GeneOntologyBiologicalProcesshindbrain morphogenesis

SLC25A46 AGTPBP1 PCNT

7.02e-0464563GO:0021575
GeneOntologyBiologicalProcessregulation of gamma-delta T cell differentiation

STAT5A STAT5B

7.43e-0415562GO:0045586
GeneOntologyBiologicalProcessregulation of lymphocyte differentiation

ERBB2 PGLYRP2 STAT5A STAT5B SOS1

7.67e-04266565GO:0045619
GeneOntologyBiologicalProcessluteinization

STAT5A STAT5B

8.48e-0416562GO:0001553
GeneOntologyBiologicalProcesscerebellar cortex development

SLC25A46 AGTPBP1 PCNT

9.51e-0471563GO:0021695
GeneOntologyBiologicalProcessregulation of gamma-delta T cell activation

STAT5A STAT5B

9.59e-0417562GO:0046643
GeneOntologyBiologicalProcesscerebellar Purkinje cell differentiation

SLC25A46 AGTPBP1

1.08e-0318562GO:0021702
GeneOntologyBiologicalProcessgamma-delta T cell differentiation

STAT5A STAT5B

1.33e-0320562GO:0042492
GeneOntologyBiologicalProcessnegative regulation of digestive system process

ABCG8 WNK3

1.33e-0320562GO:0060457
GeneOntologyBiologicalProcesscerebellar Purkinje cell layer formation

SLC25A46 AGTPBP1

1.33e-0320562GO:0021694
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

2.04e-047592IPR013799
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

2.04e-047592IPR012345
DomainSTAT

STAT5A STAT5B

2.04e-047592IPR001217
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

2.04e-047592IPR015988
Domain-

STAT5A STAT5B

2.04e-0475922.60.40.630
DomainSTAT_int

STAT5A STAT5B

2.04e-047592SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

2.04e-047592IPR013801
DomainSTAT_bind

STAT5A STAT5B

2.04e-047592PF02864
DomainSTAT_int

STAT5A STAT5B

2.04e-047592PF02865
Domain-

STAT5A STAT5B

2.04e-0475921.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

2.04e-047592PF01017
Domain-

STAT5A STAT5B

2.04e-0475921.20.1050.20
DomainSTAT_TF_alpha

STAT5A STAT5B

2.71e-048592IPR013800
Domain-

HEATR6 ANKAR MROH5 FRYL AGTPBP1

6.74e-042225951.25.10.10
DomainARM-type_fold

HEATR6 ANKAR MROH5 FRYL PPP6R1 AGTPBP1

6.86e-04339596IPR016024
DomainARM-like

HEATR6 ANKAR MROH5 FRYL AGTPBP1

1.61e-03270595IPR011989
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B SOS1

4.60e-0611443MM15578
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

STAT5A STAT5B SOS1

1.01e-0514443M27858
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B SOS1

1.26e-0515443MM1412
PathwayBIOCARTA_IL3_PATHWAY

STAT5A STAT5B SOS1

1.26e-0515443M17681
PathwayREACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS

STAT5A STAT5B SOS1

1.54e-0516443M41733
PathwayREACTOME_SIGNALING_BY_FLT3_FUSION_PROTEINS

STAT5A STAT5B SOS1

2.65e-0519443M41732
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B SOS1

2.65e-0519443M12836
PathwayBIOCARTA_EPO_PATHWAY

STAT5A STAT5B SOS1

3.12e-0520443MM1389
PathwayREACTOME_SIGNALING_BY_KIT_IN_DISEASE

STAT5A STAT5B SOS1

3.12e-0520443M39002
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B SOS1

4.19e-0522443M7747
PathwayBIOCARTA_IL2_PATHWAY

STAT5A STAT5B SOS1

4.81e-0523443MM1411
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B SOS1

4.81e-0523443MM1424
PathwayBIOCARTA_GLEEVEC_PATHWAY

STAT5A STAT5B SOS1

4.81e-0523443M7897
PathwayBIOCARTA_TPO_PATHWAY

STAT5A STAT5B SOS1

5.49e-0524443M11520
PathwayWP_RAC1PAK1P38MMP2_PATHWAY

ERBB2 STAT5A STAT5B SOS1

5.81e-0568444M39456
PathwayBIOCARTA_TPO_PATHWAY

STAT5A STAT5B SOS1

6.22e-0525443MM1519
PathwayREACTOME_SIGNALING_BY_ERYTHROPOIETIN

STAT5A STAT5B SOS1

6.22e-0525443M27865
PathwayWP_EPO_RECEPTOR_SIGNALING

STAT5A STAT5B SOS1

7.02e-0526443M39687
PathwayWP_EPO_RECEPTOR_SIGNALING

STAT5A STAT5B SOS1

7.02e-0526443MM15896
PathwayWP_NONSMALL_CELL_LUNG_CANCER

ERBB2 STAT5A STAT5B SOS1

7.28e-0572444M39738
PathwayBIOCARTA_GH_PATHWAY

STAT5A STAT5B SOS1

7.88e-0527443M9043
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

STAT5A STAT5B SOS1

7.88e-0527443MM14712
PathwayREACTOME_FLT3_SIGNALING_IN_DISEASE

STAT5A STAT5B SOS1

8.80e-0528443M41724
PathwayWP_PROLACTIN_SIGNALING

ERBB2 STAT5A STAT5B SOS1

8.99e-0576444M39601
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

9.46e-055442M48987
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

9.46e-055442M48986
PathwayKEGG_MEDICUS_REFERENCE_PRL_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

9.46e-055442M49006
PathwayWP_PDGFRBETA_PATHWAY

STAT5A STAT5B SOS1

9.80e-0529443M39616
PathwayREACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION

STAT5A STAT5B SOS1

9.80e-0529443M779
PathwayPID_IL2_STAT5_PATHWAY

STAT5A STAT5B SOS1

1.09e-0430443M234
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

1.42e-046442MM15581
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

1.42e-046442MM15621
PathwayPID_EPO_PATHWAY

STAT5A STAT5B SOS1

1.45e-0433443M233
PathwayBIOCARTA_GH_PATHWAY

STAT5A STAT5B SOS1

1.45e-0433443MM1404
PathwayKEGG_ERBB_SIGNALING_PATHWAY

ERBB2 STAT5A STAT5B SOS1

1.52e-0487444M12467
PathwayREACTOME_INTERLEUKIN_2_FAMILY_SIGNALING

STAT5A STAT5B SOS1

1.73e-0435443MM15144
PathwayBIOCARTA_IL2RB_PATHWAY

STAT5A STAT5B SOS1

1.89e-0436443MM1418
PathwayPID_GMCSF_PATHWAY

STAT5A STAT5B SOS1

1.89e-0436443M22
PathwayWP_ERBB_SIGNALING

ERBB2 STAT5A STAT5B SOS1

1.89e-0492444M39715
PathwayREACTOME_STAT5_ACTIVATION

STAT5A STAT5B

1.98e-047442M27953
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_P12_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.98e-047442M47581
PathwayKEGG_MEDICUS_REFERENCE_GH_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.98e-047442M47646
PathwayKEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.98e-047442M47430
PathwayREACTOME_ERYTHROPOIETIN_ACTIVATES_STAT5

STAT5A STAT5B

1.98e-047442M27907
PathwayBIOCARTA_IL2RB_PATHWAY

STAT5A STAT5B SOS1

2.05e-0437443M8615
PathwayREACTOME_SIGNALING_BY_SCF_KIT

STAT5A STAT5B SOS1

2.05e-0437443MM14564
PathwayREACTOME_SIGNALING_BY_FGFR1_IN_DISEASE

STAT5A STAT5B SOS1

2.22e-0438443M27536
PathwayREACTOME_FLT3_SIGNALING

STAT5A STAT5B SOS1

2.22e-0438443M29803
PathwayPID_ERBB4_PATHWAY

ERBB2 STAT5A STAT5B

2.22e-0438443M13
PathwayWP_IL5_SIGNALING

STAT5A STAT5B SOS1

2.59e-0440443M39392
PathwayWP_IL6_SIGNALING_PATHWAY

ERBB2 STAT5A STAT5B SOS1

2.60e-04100444MM15826
PathwayREACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING

STAT5A STAT5B SOS1

2.78e-0441443MM15162
PathwayWP_IL2_SIGNALING

STAT5A STAT5B SOS1

2.99e-0442443M39536
PathwayPID_TCPTP_PATHWAY

STAT5A STAT5B SOS1

2.99e-0442443M91
PathwayWP_IL7_SIGNALING_PATHWAY

STAT5A STAT5B SOS1

3.21e-0443443MM15864
PathwayREACTOME_SIGNALING_BY_SCF_KIT

STAT5A STAT5B SOS1

3.21e-0443443M508
PathwayREACTOME_INTERLEUKIN_9_SIGNALING

STAT5A STAT5B

3.38e-049442M27861
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

3.38e-049442MM1419
PathwayBIOCARTA_IL22BP_PATHWAY

STAT5A STAT5B

3.38e-049442M8066
PathwayREACTOME_INTERLEUKIN_2_FAMILY_SIGNALING

STAT5A STAT5B SOS1

3.44e-0444443M1012
PathwayWP_ERBB_SIGNALING_PATHWAY

ERBB2 STAT5A SOS1

3.92e-0446443MM15950
PathwayREACTOME_INTERLEUKIN_21_SIGNALING

STAT5A STAT5B

4.22e-0410442M27898
PathwayREACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS

STAT5A STAT5B

4.22e-0410442M41731
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

4.22e-0410442MM15618
PathwayREACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING

STAT5A STAT5B SOS1

4.45e-0448443M914
PathwayWP_IL3_SIGNALING

STAT5A STAT5B SOS1

4.73e-0449443M39722
PathwayREACTOME_SIGNALING_BY_LEPTIN

STAT5A STAT5B

5.14e-0411442M27195
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2

ERBB2 SOS1

5.14e-0411442M29814
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

ERBB2 SOS1

5.14e-0411442MM14760
PathwayREACTOME_INTERLEUKIN_2_SIGNALING

STAT5A STAT5B

6.16e-0412442M27893
PathwayWP_IL4_SIGNALING

STAT5A STAT5B SOS1

6.30e-0454443M39720
PathwayPID_IL2_1PATHWAY

STAT5A STAT5B SOS1

6.65e-0455443M122
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PUBERTY_STAGE_2_OF_4

ERBB2 STAT5A

7.27e-0413442M39582
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

STAT5A STAT5B SOS1

7.38e-0457443M19888
PathwayREACTOME_SIGNALING_BY_PDGF

STAT5A STAT5B SOS1

7.38e-0457443MM14713
PathwayREACTOME_SIGNALING_BY_PDGF

STAT5A STAT5B SOS1

7.77e-0458443M2049
PathwayWP_KIT_RECEPTOR_SIGNALING

STAT5A STAT5B SOS1

8.16e-0459443M39350
PathwayPID_IL5_PATHWAY

STAT5A STAT5B

8.46e-0414442M135
PathwayWP_FOXP3_IN_COVID19

STAT5A STAT5B

9.74e-0415442M42573
PathwayREACTOME_PROLACTIN_RECEPTOR_SIGNALING

STAT5A STAT5B

9.74e-0415442M552
PathwayREACTOME_INTERLEUKIN_7_SIGNALING

STAT5A STAT5B

9.74e-0415442MM14536
PathwayREACTOME_SIGNALING_BY_FGFR_IN_DISEASE

STAT5A STAT5B SOS1

9.89e-0463443M635
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

ERBB2 SOS1

1.11e-0316442M47381
PathwayREACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING

STAT5A STAT5B

1.11e-0316442MM15710
PathwayREACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING

ERBB2 SOS1

1.11e-0316442M562
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.11e-0316442M1296
PathwayBIOCARTA_IL7_PATHWAY

STAT5A STAT5B

1.11e-0316442MM1420
PathwayREACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS

ERBB2 SOS1

1.11e-0316442M29847
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

ERBB2 STAT5A SOS1

1.13e-0366443M39642
PathwayWP_ACUTE_MYELOID_LEUKEMIA

STAT5A STAT5B SOS1

1.23e-0368443M48322
PathwayWP_IL9_SIGNALING

STAT5A STAT5B

1.26e-0317442M39644
PathwayKEGG_MEDICUS_REFERENCE_HORMONE_LIKE_CYTOKINE_TO_JAK_STAT_SIGNALING_PATHWAY

STAT5A STAT5B

1.26e-0317442M47905
PathwayWP_KIT_RECEPTOR_SIGNALING_PATHWAY

STAT5A STAT5B SOS1

1.40e-0371443MM15947
PathwayREACTOME_SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS

STAT5A STAT5B

1.41e-0318442M673
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

STAT5A STAT5B SOS1

1.52e-0373443M321
PathwayWP_EGFEGFR_SIGNALING

ERBB2 STAT5A STAT5B SOS1

1.60e-03162444M39334
PathwayWP_LEPTIN_SIGNALING

ERBB2 STAT5B SOS1

1.70e-0376443M39491
PathwayREACTOME_INTERLEUKIN_20_FAMILY_SIGNALING

STAT5A STAT5B

1.75e-0320442MM15496
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB2 SOS1

2.11e-0322442M26929
PathwayBIOCARTA_HER2_PATHWAY

ERBB2 SOS1

2.31e-0323442MM1480
Pubmed

Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.

POLH XPC REV3L XRCC3

1.48e-072859419661089
Pubmed

Distribution of the mammalian Stat gene family in mouse chromosomes.

ERBB2 STAT5A STAT5B

1.31e-06135938530075
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SETDB2 ERBB2 EP400 OAS3 XPC PPP6R1 SIK3 REV3L ELL3 AGTPBP1 SOS1

2.41e-061116591131753913
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

2.83e-06259223151802
Pubmed

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

STAT5A STAT5B

2.83e-06259226999798
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

2.83e-06259220233708
Pubmed

A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.

ERBB2 ADAM12

2.83e-06259221986939
Pubmed

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

STAT5A STAT5B

2.83e-06259216775227
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

2.83e-06259231443474
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

2.83e-06259217447893
Pubmed

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

STAT5A STAT5B

2.83e-06259212377952
Pubmed

A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.

POLH REV3L

2.83e-06259227481099
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

2.83e-06259221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

2.83e-06259216289657
Pubmed

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.

STAT5A STAT5B

2.83e-06259225552366
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

2.83e-06259225470773
Pubmed

DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.

POLH REV3L

2.83e-06259222615128
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

2.83e-06259221431790
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

2.83e-06259216115927
Pubmed

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration.

STAT5A STAT5B

2.83e-06259223275557
Pubmed

Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.

STAT5A STAT5B

2.83e-06259228500076
Pubmed

STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.

STAT5A STAT5B

2.83e-06259221826656
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

2.83e-06259211867689
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

2.83e-0625927720707
Pubmed

The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.

POLH REV3L

2.83e-06259226727495
Pubmed

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

STAT5A STAT5B

2.83e-06259215980098
Pubmed

STAT5A and STAT5B have opposite correlations with drug response gene expression.

STAT5A STAT5B

2.83e-06259227264955
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

2.83e-06259215340066
Pubmed

Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells.

ERBB2 STAT5B

2.83e-06259226648017
Pubmed

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.

STAT5A STAT5B

2.83e-06259222159083
Pubmed

STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.

STAT5A STAT5B

2.83e-06259220008792
Pubmed

Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.

ERBB2 ADAM12

2.83e-06259224798404
Pubmed

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.

STAT5A STAT5B

2.83e-06259233199496
Pubmed

STAT5A/B gene locus undergoes amplification during human prostate cancer progression.

STAT5A STAT5B

2.83e-06259223660011
Pubmed

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

STAT5A STAT5B

2.83e-06259212901872
Pubmed

O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies.

STAT5A STAT5B

2.83e-06259228074064
Pubmed

STAT5b: A master regulator of key biological pathways.

STAT5A STAT5B

2.83e-06259236755813
Pubmed

The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.

STAT5A STAT5B

2.83e-06259216502315
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

2.83e-06259212217382
Pubmed

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

STAT5A STAT5B

2.83e-06259225333863
Pubmed

A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.

STAT5A STAT5B

2.83e-06259212421978
Pubmed

A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities.

STAT5A STAT5B

2.83e-0625929852045
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

2.83e-06259231599926
Pubmed

Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

STAT5A STAT5B

2.83e-06259219966185
Pubmed

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

STAT5A STAT5B

2.83e-06259221704724
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

2.83e-06259210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

2.83e-06259221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

2.83e-06259210486277
Pubmed

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

STAT5A STAT5B

2.83e-06259238618957
Pubmed

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

STAT5A STAT5B

2.83e-06259216840779
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

2.83e-06259215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

2.83e-06259230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

2.83e-06259223565285
Pubmed

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

STAT5A STAT5B

2.83e-06259232790723
Pubmed

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

STAT5A STAT5B

2.83e-0625928732682
Pubmed

In vivo identification of novel STAT5 target genes.

STAT5A STAT5B

2.83e-06259218492722
Pubmed

How Intrinsic Molecular Dynamics Control Intramolecular Communication in Signal Transducers and Activators of Transcription Factor STAT5.

STAT5A STAT5B

2.83e-06259226717567
Pubmed

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

STAT5A STAT5B

2.83e-06259210066807
Pubmed

Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains.

STAT5A STAT5B

2.83e-06259210835485
Pubmed

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis.

STAT5A STAT5B

2.83e-06259235464049
Pubmed

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.

STAT5A STAT5B

2.83e-06259232281944
Pubmed

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity.

STAT5A STAT5B

2.83e-06259218286195
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

2.83e-06259223773921
Pubmed

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

STAT5A STAT5B

2.83e-0625928631883
Pubmed

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

STAT5A STAT5B

2.83e-06259211030348
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

2.83e-06259224878107
Pubmed

Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice.

STAT5A STAT5B

2.83e-06259234818373
Pubmed

Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5.

STAT5A STAT5B

2.83e-06259212847485
Pubmed

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma.

STAT5A STAT5B

2.83e-06259212835478
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

2.83e-0625927568026
Pubmed

Identification of STAT5A and STAT5B target genes in human T cells.

STAT5A STAT5B

2.83e-06259224497979
Pubmed

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting.

STAT5A STAT5B

2.83e-06259223465551
Pubmed

STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells.

STAT5A STAT5B

2.83e-06259211756158
Pubmed

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

STAT5A STAT5B

2.83e-06259217536022
Pubmed

STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line.

STAT5A STAT5B

2.83e-06259217382296
Pubmed

STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation.

STAT5A STAT5B

2.83e-06259217911616
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

2.83e-06259210486314
Pubmed

The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging.

STAT5A STAT5B

2.83e-06259217599554
Pubmed

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.

STAT5A STAT5B

2.83e-06259224497923
Pubmed

IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice.

STAT5A STAT5B

2.83e-06259229203513
Pubmed

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia.

STAT5A STAT5B

2.83e-06259227367207
Pubmed

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

STAT5A STAT5B

2.83e-06259216493008
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

2.83e-06259224335105
Pubmed

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

STAT5A STAT5B

2.83e-0625928816482
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

2.83e-06259229460051
Pubmed

The role of STAT proteins in growth hormone signaling.

STAT5A STAT5B

2.83e-06259210851057
Pubmed

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

STAT5A STAT5B

2.83e-06259228806763
Pubmed

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells.

STAT5A STAT5B

2.83e-06259229105654
Pubmed

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.

STAT5A STAT5B

2.83e-06259217003334
Pubmed

Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context.

STAT5A STAT5B

2.83e-06259217438530
Pubmed

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

STAT5A STAT5B

2.83e-06259215677477
Pubmed

A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.

STAT5A STAT5B

2.83e-06259216757175
Pubmed

Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression.

STAT5A STAT5B

2.83e-06259215677453
Pubmed

Haploinsufficiency identifies STAT5 as a modifier of IL-7-induced lymphomas.

STAT5A STAT5B

2.83e-06259215870688
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

2.83e-06259228606561
Pubmed

Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A.

STAT5A STAT5B

2.83e-06259219833766
Pubmed

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus.

STAT5A STAT5B

2.83e-06259217317776
Pubmed

Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis.

STAT5A STAT5B

2.83e-06259220415542
Pubmed

Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells.

STAT5A STAT5B

2.83e-06259223332799
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

2.83e-06259212393407
GeneFamilyWD repeat domain containing|Xeroderma pigmentosum complementation groups|Nucleotide excision repair

POLH XPC

1.33e-0484021125
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TCTE1 ATF3 C1orf167 REV3L DTD2 WNK3

5.88e-08155596335cd798afbaa0a3a3e1dc558a81cfa32da48983
ToppCell367C-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TCTE1 OAS3 ATF3 C1orf167 DTD2 WNK3

6.11e-08156596fc8b8aef29d6d1c0f0c1d08280d8aaff8d30535e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

CCNF OAS3 PPP6R1 ABCG8 ANO8

2.91e-06168595ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

TCTE1 KIF27 PLEKHG7 ANKFN1 ALOX12B

6.80e-0620059596701a4d57753f5ec0dd5c7550054bbcc946bc5f
ComputationalNeighborhood of PPP5C

CCNF EP400 FRYL REV3L

1.84e-0491344MORF_PPP5C
DiseaseXeroderma Pigmentosum

POLH XPC

2.12e-054562C0043346
Diseasexeroderma pigmentosum (implicated_via_orthology)

POLH XPC

5.28e-056562DOID:0050427 (implicated_via_orthology)
Diseaseinvasive lobular carcinoma (is_marker_for)

ERBB2 STAT5A

7.38e-057562DOID:3457 (is_marker_for)
DiseaseXeroderma pigmentosum

POLH XPC

1.26e-049562cv:C0043346
DiseaseBasal cell carcinoma

XPC STAT5B

1.92e-0411562C0007117
Diseasecampesterol measurement

ANKFN1 ABCG8

1.92e-0411562EFO_0020008
DiseaseAdenocarcinoma of lung (disorder)

ERBB2 XPC ALOX12B SOS1

6.38e-04206564C0152013
Diseasecolon adenocarcinoma (is_implicated_in)

STAT5A STAT5B

1.12e-0326562DOID:234 (is_implicated_in)
Diseasegastric adenocarcinoma (is_marker_for)

STAT5A STAT5B

1.30e-0328562DOID:3717 (is_marker_for)
DiseasePigmented Basal Cell Carcinoma

ERBB2 XRCC3

1.30e-0328562C1368275
DiseaseCarcinoma, Basal Cell

ERBB2 XRCC3

1.39e-0329562C4721806
DiseaseCarcinoma, Granular Cell

ERBB2 ALOX12B STAT5A

1.41e-03116563C0205644
DiseaseAdenocarcinoma, Tubular

ERBB2 ALOX12B STAT5A

1.41e-03116563C0205645
DiseaseAdenocarcinoma, Oxyphilic

ERBB2 ALOX12B STAT5A

1.41e-03116563C0205642
DiseaseCarcinoma, Cribriform

ERBB2 ALOX12B STAT5A

1.41e-03116563C0205643
DiseaseAdenocarcinoma, Basal Cell

ERBB2 ALOX12B STAT5A

1.41e-03116563C0205641
DiseaseAdenocarcinoma

ERBB2 ALOX12B STAT5A

1.41e-03116563C0001418
DiseaseHead and Neck Neoplasms

ERBB2 XRCC3

1.80e-0333562C0018671

Protein segments in the cluster

PeptideGeneStartEntry
IAHNQVRQVPLQRLR

ERBB2

86

P04626
NVLSILVRLQRICNH

EP400

1356

Q96L91
QLEHVQTRLREIQPC

RNF40

876

O75150
HQRCTVTRPEQLLLQ

C1orf167

1011

Q5SNV9
ALQECQRQQVRPVIA

ELL3

36

Q9HB65
LEICHPQERNIFNRI

ACOT9

296

Q9Y305
PQLVRKCVAHVRQHN

ABCG8

141

Q9H221
RIAFQQHRRPLIQCL

BTBD11

831

A6QL63
RLLQCQNVDISRPLN

ADAM12

791

O43184
VKQNLQNHRLVLPCL

AGTPBP1

166

Q9UPW5
QNHRLVLPCLQLLRV

AGTPBP1

171

Q9UPW5
QQVFPVHEQRILNRL

ANO8

206

Q9HCE9
LCNVRQQAIPASHNI

RAD51AP2

786

Q09MP3
QPILRFLQLLCENHN

ITPR3

1871

Q14573
INRRKRLVQLPCHTN

MSL3P1

116

P0C860
RPRIVCLNQLGKHVQ

ANKAR

1411

Q7Z5J8
SQPCVHLQAQIQIRV

CD68

166

P34810
ELCIQHIIRNFQKNP

TCTE1

81

Q5JU00
RIPQARALLQQCLHA

DTD2

6

Q96FN9
LHNHQVCVRVIPNSQ

KIF27

21

Q86VH2
VLLQRLEPVHLQLQC

PGLYRP2

341

Q96PD5
ALVANIIQNVPVHQR

FRYL

1046

O94915
QACRLVPLNQNHLVS

HEATR6

81

Q6AI08
SLQRQQQPEAALLRC

LONRF2

206

Q1L5Z9
RQLQVLHQRFLRCQV

PCNT

1931

O95613
ICRIVCRHAQQIALQ

GPR3

216

P46089
SSHPIIRQIRQACAQ

CHCHD5

46

Q9BSY4
FCNAVIQVAHPLIRN

FHIP1A

291

Q05DH4
PQQQVKRINLCIHSE

CCNF

761

P41002
LIQCNQDQPDRIHLL

FSCN3

406

Q9NQT6
LNLHRPTCIVRAQNG

ATF3

146

P18847
QISHDIRQRNKCLPI

ALOX12B

671

O75342
RNPQVHQRVSECLRV

PAFAH2

181

Q99487
RTVLGLVQQHQQLCV

OAS3

656

Q9Y6K5
VRHICLEGQLIRVNQ

OTOG

2061

Q6ZRI0
VQNHCRQIPAVLRQL

MROH5

991

Q6ZUA9
ACHNQHLQLQPPRRR

NT5M

196

Q9NPB1
IPSLQQLHLQRNALC

LRRC27

66

Q9C0I9
QLHLQRNALCVIPQD

LRRC27

71

Q9C0I9
CENQPALLTHQLQRL

SIK3

711

Q9Y2K2
QQIRRAEHLCQQLPI

STAT5B

291

P51692
CFFVQVEQRQNPHLR

POLH

16

Q9Y253
YIQPVQLRVLNVCRH

SOS1

681

Q07889
QCLQHIPVNEENRRS

MTRF1

91

O75570
CRQVISQLPRCHRNV

OCRL

821

Q01968
LTHAIKNCPVINNRQ

SPICE1

446

Q8N0Z3
QQIRRAEHLCQQLPI

STAT5A

291

P42229
LQQINIPLHQARNFR

ANKFN1

691

Q8N957
HPQLKQCVRQAIERA

CNOT1

1386

A5YKK6
LQAVINEVCRHRPLN

MRPL1

271

Q9BYD6
CQNRVVQHGPQVRLQ

SETDB2

356

Q96T68
KCRSQPQHVAVILNQ

REV3L

3056

O60673
LAHPCIVLRRQCQVN

SLC25A46

116

Q96AG3
VSQPRRNIVGCRIQH

SPIN1

46

Q9Y657
QLFHRCQRAVQALPS

STX16

131

O14662
PVQRAAICQNLQHVL

TONSL

276

Q96HA7
AICQNLQHVLAVVRL

TONSL

281

Q96HA7
CRVEHARQQLQQVPG

TTLL12

126

Q14166
QNPVVKHLLQQCRLV

PPP6R1

426

Q9UPN7
QNEQCRRLHVPELLV

PLEKHG7

421

Q6ZR37
CVQLNLPNLHRVARK

XPC

771

Q01831
LALQLCLAVQFPRQH

XRCC3

116

O43542
ALAQQQVRRTPAQCR

UTF1

101

Q5T230
HVRQQLLQRKPQQHC

WNK3

546

Q9BYP7