Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainAutophagy-rel_prot_16

ATG16L1 ATG16L2

2.56e-052952IPR013923
DomainATG16

ATG16L1 ATG16L2

2.56e-052952PF08614
DomainTEX13

TEX13B TEX13A

7.65e-053952PF15186
DomainTEX13

TEX13B TEX13A

7.65e-053952IPR028193
DomainLRRC8_Pannexin-like

LRRC8E LRRC8A

2.53e-045952IPR021040
DomainPannexin_like

LRRC8E LRRC8A

2.53e-045952PF12534
DomainRhoGAP

MYO9A INPP5B DLC1 ARHGAP21

2.80e-0462954SM00324
DomainRhoGAP

MYO9A INPP5B DLC1 ARHGAP21

2.97e-0463954PF00620
DomainRHOGAP

MYO9A INPP5B DLC1 ARHGAP21

3.16e-0464954PS50238
DomainRhoGAP_dom

MYO9A INPP5B DLC1 ARHGAP21

3.16e-0464954IPR000198
Domain-

MYO9A INPP5B DLC1 ARHGAP21

3.16e-04649541.10.555.10
DomainWD_REPEATS_1

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD RIC1 ATG16L2

5.43e-04278957PS00678
DomainWD_REPEATS_2

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD RIC1 ATG16L2

5.55e-04279957PS50082
DomainWD_REPEATS_REGION

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD RIC1 ATG16L2

5.55e-04279957PS50294
DomainWD40_repeat_dom

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD RIC1 ATG16L2

8.02e-04297957IPR017986
DomainG-protein_beta_WD-40_rep

ATG16L1 TBL1XR1 GNB4 ATG16L2

9.28e-0485954IPR020472
DomainRho_GTPase_activation_prot

MYO9A INPP5B DLC1 ARHGAP21

1.06e-0388954IPR008936
Domain-

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD RIC1 ATG16L2

1.55e-033339572.130.10.10
DomainWD40/YVTN_repeat-like_dom

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD RIC1 ATG16L2

1.61e-03335957IPR015943
DomainWD40

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD ATG16L2

2.08e-03259956PF00400
DomainFN_type2_col-bd

PLA2R1 LY75

2.24e-0314952IPR000562
DomainFN2_2

PLA2R1 LY75

2.24e-0314952PS51092
DomainDynein_heavy_dom-2

DNHD1 DNAH12

2.24e-0314952IPR013602
DomainDHC_N2

DNHD1 DNAH12

2.24e-0314952PF08393
DomainTIL_dom

ZAN LRP2

2.24e-0314952IPR002919
Domainfn2

PLA2R1 LY75

2.24e-0314952PF00040
DomainFN2_1

PLA2R1 LY75

2.24e-0314952PS00023
DomainFN2

PLA2R1 LY75

2.24e-0314952SM00059
DomainWD40

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD ATG16L2

2.47e-03268956SM00320
DomainDHC_fam

DNHD1 DNAH12

2.57e-0315952IPR026983
DomainDynein_heavy_dom

DNHD1 DNAH12

2.57e-0315952IPR004273
DomainDynein_heavy

DNHD1 DNAH12

2.57e-0315952PF03028
DomainWD40_repeat

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD ATG16L2

2.66e-03272956IPR001680
DomainLH2

LOXHD1 PKD1

3.71e-0318952SM00308
DomainZinc_finger_PHD-type_CS

ZMYND8 DIDO1 KDM5D

4.43e-0365953IPR019786
DomainPLAT

LOXHD1 PKD1

5.05e-0321952PS50095
Domain-

LOXHD1 PKD1

5.05e-03219522.60.60.20
DomainPLAT

LOXHD1 PKD1

5.05e-0321952PF01477
DomainPLAT/LH2_dom

LOXHD1 PKD1

5.05e-0321952IPR001024
Domainzf-CCHC

RBM4B RBM4

6.04e-0323952PF00098
DomainPHD

ZMYND8 DIDO1 KDM5D

6.61e-0375953PF00628
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LRRC8E ATG10 ADGRB2 ZNF395 WRAP53 PIAS4 TRIB3 KANK3 PKD1 UNKL DMWD SUFU ARHGAP21 RIC1

2.37e-061105971435748872
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KIF13B ILK KLHDC2 MYO9A MAP3K20 MELK GLCCI1 DLC1 FOXO4 PEAK1 PLCH1 ARHGAP21

5.10e-06861971236931259
Pubmed

Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.

RBM4 ADGRB2 LRP2

5.89e-061397312508107
Pubmed

The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.

RBM4B RBM4

7.70e-06297218708123
Pubmed

Phylogenetic and molecular characterization of the splicing factor RBM4.

RBM4B RBM4

7.70e-06297223527094
Pubmed

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.

LRRC8E LRRC8A

7.70e-06297233139539
Pubmed

Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with nasopharyngeal carcinoma.

ATG10 ATG16L2

7.70e-06297231692259
Pubmed

Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells.

SOX11 BRCA1

7.70e-06297233969421
Pubmed

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.

ATG16L1 ATG16L2

7.70e-06297231451676
Pubmed

Association of ATG10 rs1864183, ATG16L1 rs2241880 and miR-126 with esophageal cancer.

ATG16L1 ATG10

2.31e-05397238281293
Pubmed

Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.

BRCA1 RAD54L

2.31e-05397232333827
Pubmed

Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation.

TEX13B TEX13A

2.31e-05397214531651
Pubmed

RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.

RBM4B RBM4

2.31e-05397227821480
Pubmed

A novel splicing regulator shares a nuclear import pathway with SR proteins.

RBM4B RBM4

2.31e-05397212628928
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

AVEN ATG16L1 RBM4 MAP3K20 TBL1XR1 GLCCI1 GTF3C5 GPBP1L1 GNB4 DMWD ARHGAP21 ATG16L2

3.25e-051038971226673895
Pubmed

Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

GLP1R PLCH1

4.60e-05497221041529
Pubmed

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

LRRC8E LRRC8A

4.60e-05497226824658
Pubmed

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.

ATG16L1 ATG16L2

4.60e-05497212665549
Pubmed

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy.

ATG16L1 ATG16L2

4.60e-05497231636955
Pubmed

Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors.

ATG16L1 ATG16L2

4.60e-05497223439083
Pubmed

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

LRRC8E LRRC8A

4.60e-05497228193731
Pubmed

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.

LRRC8E LRRC8A

4.60e-05497233171122
Pubmed

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.

ATG16L1 ATG16L2

4.60e-05497211266458
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

KIF13B INPP5B DIDO1 TACC2 UBOX5 SDR39U1 SIAE LRP2 PEAK1 DMWD ARHGAP21 VPS13B

4.94e-051084971211544199
Pubmed

Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.

LRRC8E LRRC8A

7.66e-05597235777784
Pubmed

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.

ATG16L1 ATG16L2

7.66e-05597223202584
Pubmed

LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.

LRRC8E LRRC8A

7.66e-05597215094057
Pubmed

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

LRRC8E LRRC8A

7.66e-05597224790029
Pubmed

The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules.

ERAP1 KDM5D

7.66e-05597216299505
Pubmed

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

PIAS4 BRCA1

1.15e-04697220016594
Pubmed

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.

ATG16L1 ATG16L2

1.15e-04697222082872
Pubmed

RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression.

RBM4B RBM4

1.15e-04697227009199
Pubmed

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.

TEX13B KDM5D TEX13A

1.18e-043497331201419
Pubmed

LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1.

RBM4B RBM4

1.60e-04797217264215
Pubmed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

ATG16L1 WRAP53 ATG16L2

1.93e-044097329078390
Pubmed

Cloning, characterization, and genomic structure of the mouse Ikbkap gene.

MELK ACTL7B

2.13e-04897211747609
Pubmed

Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1.

BRCA1 ADAT2

2.74e-04997232290274
Pubmed

The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.

ATG16L1 DACT2

2.74e-04997225825496
Pubmed

Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency.

RBM4B RBM4

2.74e-04997237670183
Pubmed

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.

PIAS4 BRCA1

2.74e-04997220016603
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

MYO9A TNRC6B PEAK1 SUFU ARHGAP21

3.07e-0420997536779422
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

ZMYND8 DHX57 LOXHD1 DNAH12 HPX ARHGAP21 RIC1

4.95e-0449797736774506
Pubmed

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

LRRC8E LRRC8A

4.99e-041297232277911
Pubmed

RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.

RBM4B RBM4

4.99e-041297229581187
Pubmed

UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.

ATG16L1 ATG16L2

5.89e-041397224550300
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

TEX13B TEX13A MOV10L1

6.10e-045997311279525
Pubmed

Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening.

DIDO1 BRCA1 FBXO34

6.73e-046197335205757
Pubmed

Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.

TEX13B MOV10L1

6.85e-041497221079677
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

KIF13B ATG16L1 MYO9A ZMYND8 WRAP53 MELK GTF3C5 SOCS7 GPBP1L1 EIF4E3 ATG16L2

6.93e-041242971130973865
Pubmed

Analysis of BCL6-interacting proteins by tandem mass spectrometry.

KIF13B ZMYND8 TRIB3

7.06e-046297316147992
Pubmed

E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.

RBM4 TRIB3

7.89e-041597218276110
Pubmed

High-throughput mapping of a dynamic signaling network in mammalian cells.

AVEN ATG16L1 INPP5B UNKL FBXO34

8.27e-0426097515761153
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

LRRC8A KCNT1 ARHGAP21 RIC1

9.08e-0415397410718198
Pubmed

Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition.

AVEN PIAS4

1.02e-031797233634103
Pubmed

RBM4 promotes pancreas cell differentiation and insulin expression.

RBM4B RBM4

1.02e-031797223129807
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

ILK KLHDC2 MYO9A ZMYND8 ADGRB2 DIDO1 WRAP53 SDR39U1 PKD1

1.13e-0392597928986522
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

TNRC6B DHX57 GTF3C5 MTMR11

1.26e-0316797425659891
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIF13B ADGRB2 TNRC6B DIDO1 TBL1XR1 SLC1A2 TMEM132B KCNT1 ARHGAP21

1.50e-0396397928671696
Pubmed

BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer

BRCA1 RAD54L

1.56e-032197220301425
Pubmed

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.

PKD1 LRP2

1.56e-032197227591083
Pubmed

Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.

BRCA1 LRP2

1.71e-032297212768436
Pubmed

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics.

TRIB3 LRP2

1.71e-032297210438476
Pubmed

Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.

ATG16L1 DNAH12

1.71e-032297219174780
Pubmed

A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.

SOX11 ATG16L2

1.71e-032297223266558
Pubmed

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

TEX13B MOV10L1

1.71e-032297230518531
Pubmed

Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.

ATG16L1 DNAH12

1.87e-032397220886065
Pubmed

Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

PLA2R1 LY75

2.04e-032497221323541
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

RBM4B RBM4 TNRC6B MELK GPBP1L1

2.12e-0332297539098523
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

TNRC6B DHX57 TBL1XR1 SYT11 LRRC8A KCNT1

2.18e-0347597631040226
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

AVEN RBM4 INPP5B GLCCI1 MOV10L1

2.24e-0332697517015433
Pubmed

Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.

BRCA1 RAD54L

2.58e-032797220610542
Pubmed

SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.

BRCA1 FUT4

2.58e-032797225703348
Pubmed

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

DNHD1 BRCA1

2.58e-032797217525332
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

MYO9A GTF3C5 GNB4

2.64e-039897334943047
Pubmed

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.

PSG11 CHADL LOXHD1 DLC1

2.65e-0320597412040188
Pubmed

Genetic link between renal birth defects and congenital heart disease.

PKD1 LRP2

2.78e-032897227002738
Pubmed

Genetic risk profiling and prediction of disease course in Crohn's disease patients.

ATG16L1 DNAH12

2.78e-032897219422935
GeneFamilyVolume regulated anion channel subunits

LRRC8E LRRC8A

1.38e-0456821158
GeneFamilyAutophagy related

ATG16L1 ATG10 ATG16L2

2.56e-04336831022
GeneFamilyWD repeat domain containing

ATG16L1 WRAP53 TBL1XR1 GNB4 DMWD ATG16L2

4.51e-04262686362
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

ERAP1 KDM5D LY75

9.31e-0451683870
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

RBM4B RBM4

3.95e-032568274
GeneFamilyC2-set domain containing|Immunoglobulin like domain containing|Scavenger receptors

CD163L1 LY75

4.60e-03276821253
GeneFamilyPHD finger proteins

ZMYND8 DIDO1 KDM5D

4.73e-039068388
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 SOX11 ZAN LOXHD1 LRP2 PLCH1

3.13e-061849762cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 SOX11 ZAN LOXHD1 LRP2 PLCH1

3.13e-06184976ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIAA0408 SOX11 ZAN LOXHD1 LRP2 PLCH1

3.13e-061849762b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

TACC2 SIAE DLC1 LRP2 PLCH1 AGBL1

4.00e-0619297606013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9A TACC2 GLCCI1 DLC1 PLCH1 AGBL1

4.91e-061999768587bd98de7767a575088afbea07a1feb4516b9b
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Ntng1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZAN MELK DNAH12 SLC4A9

6.84e-0656974ad76712e6a99072f9c6dab6d746db54f754e14fd
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Ntng1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZAN MELK DNAH12 SLC4A9

6.84e-065697420a2977f41d3ecbc4fbee7ecd6dfb4b7ce0e4bb7
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ZAN MS4A10 MOV10L1 FUT4

1.58e-05699749778ec48eceef5bd6f59b5b55ca4a6cc348a1eba
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ZAN MS4A10 MOV10L1 FUT4

1.58e-05699748c4c4e2cd4c319adbe44fa2bcb5bb5cd5d81a2fd
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

INTU ADGRB2 MELK DNAH12 RAD54L

2.41e-05157975410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLK5 TMEM132B DLC1 SYT11 HPX

2.64e-0516097514dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLK5 TMEM132B DLC1 SYT11 HPX

2.64e-05160975839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLK5 TMEM132B DLC1 SYT11 HPX

2.64e-051609755b7789d4668ed7732babedc32d812233b430e0bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLK5 TMEM132B DLC1 SYT11 HPX

2.64e-05160975bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCellControl|World / group, cell type (main and fine annotations)

TACC2 DLC1 LRP2 PLCH1 AGBL1

3.34e-05168975a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellNS-critical-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADGRB2 MELK BRCA1 PRR32 RAD54L

4.17e-051769757cf1a06ceee1ec06532f44c729c31b4d58e5ea49
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

TACC2 DLC1 LRP2 PLCH1 AGBL1

4.64e-05180975198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellcellseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ADGRB2 MELK DNAH12 PRR32 RAD54L

4.89e-05182975deb53a4f84e4cd5c3b4180a4ac43249da9d738f7
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ATG16L1 FMO2 TNRC6B SOCS7 VPS13B

5.42e-0518697577bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ATG16L1 FMO2 TNRC6B SOCS7 VPS13B

5.42e-0518697513bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

TNRC6B TACC2 MELK GLCCI1 DNAH12

5.70e-05188975186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

TACC2 DLC1 LRP2 PLCH1 AGBL1

5.85e-05189975dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADGRB2 MELK DNAH12 BRCA1 RAD54L

5.99e-051909750adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCellNS-moderate-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

INTU ADGRB2 MELK BRCA1 RAD54L

5.99e-05190975250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADGRB2 MELK DNAH12 BRCA1 RAD54L

5.99e-0519097505455775845f4ded5c27e7b83242078d23162aaf
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DACT2 SLC1A2 DLC1 PLCH1 AGBL1

6.15e-0519197534cc997e4e5c727495f321e6807a84aa124da486
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

TACC2 GLCCI1 DLC1 PLCH1 AGBL1

6.30e-05192975499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

TACC2 DLC1 LRP2 PLCH1 AGBL1

6.30e-0519297558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

TACC2 GLCCI1 DLC1 PLCH1 AGBL1

6.30e-05192975efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

TACC2 DLC1 LRP2 PLCH1 AGBL1

6.46e-05193975738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TACC2 GLCCI1 DLC1 PLCH1 AGBL1

6.61e-0519497597534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PSG11 WRAP53 FOXO4 KCNT1 SLC4A9

6.61e-051949752dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO9A TACC2 GLCCI1 DLC1 PLCH1

6.78e-051959759406866f99555198a9be311fbd65751b70f35446
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TACC2 SIAE LRP2 PLCH1 AGBL1

7.28e-05198975f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9A GLCCI1 PEAK1 AGBL1 VPS13B

7.28e-051989751996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TACC2 SIAE LRP2 PLCH1 AGBL1

7.28e-051989752e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1|bone_marrow / Manually curated celltypes from each tissue

MELK BRCA1 GNB4 FUT4 RAD54L

7.28e-051989755c92687b853ebb00960adbef6552f9d460bc6886
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TACC2 DLC1 LRP2 PLCH1 AGBL1

7.46e-05199975725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9A TACC2 GLCCI1 PLCH1 AGBL1

7.46e-051999755cea0d9e261903e0eaad60c28a07dff72ce65027
DrugEthynylestradiol 3-methyl ether [72-33-3]; Up 200; 12.8uM; MCF7; HT_HG-U133A

PSG11 INPP5B ZMYND8 UBOX5 DLC1 GLP1R PLCH1 PSD4

1.89e-061959784792_UP
DrugDiperodon hydrochloride [537-12-2]; Down 200; 9.2uM; PC3; HT_HG-U133A

ATG10 INPP5B ADGRB2 TNRC6B WRAP53 GLP1R FUT4 PSD4

2.12e-061989784498_DN
Diseaseinflammatory bowel disease 10 (implicated_via_orthology)

ATG16L1 ATG16L2

9.41e-062912DOID:0110885 (implicated_via_orthology)
Diseasesecretory phospholipase A2 receptor measurement

PLA2R1 LY75

2.82e-053912EFO_0802043
DiseaseFuchs' endothelial dystrophy (is_implicated_in)

LOXHD1 AGBL1

1.40e-046912DOID:11555 (is_implicated_in)
DiseaseAlzheimer disease, polygenic risk score

ZAN MAP3K20 TACC2 MELK PLA2R1 PLCH1 LY75 SLC4A9

4.62e-04586918EFO_0030082, MONDO_0004975
Diseaseniacinamide measurement

FMO2 ZNF395

6.08e-0412912EFO_0010511
Diseaserostral middle frontal gyrus volume measurement

PLA2R1 AGBL1

8.36e-0414912EFO_0010328
Diseasesyndromic intellectual disability (implicated_via_orthology)

ZMYND8 KDM5D

1.10e-0316912DOID:0050888 (implicated_via_orthology)
DiseaseBenign Neoplasm

DLC1 BRCA1 GLP1R

1.23e-0368913C0086692
DiseaseNeoplasms

DLC1 BRCA1 GLP1R

1.23e-0368913C0027651
DiseaseCarcinoma of bladder

TBL1XR1 PEAK1

1.39e-0318912C0699885
DiseaseBREAST CANCER

BRCA1 RAD54L

1.90e-0321912114480
Diseasecortical thickness

SOX11 INTU MRPS35 TNRC6B TACC2 DLC1 PKD1 PLCH1 AGBL1 ARHGAP21

2.27e-0311139110EFO_0004840
Diseasespermatogenic failure (is_implicated_in)

MOV10L1 SHOC1

2.28e-0323912DOID:0111910 (is_implicated_in)
Diseaseapolipoprotein L1 measurement

DLC1 HPX

2.69e-0325912EFO_0021854

Protein segments in the cluster

PeptideGeneStartEntry
SGAEHWREVCESPRK

SYT11

406

Q9BT88
PAWATCTGALTDTRE

ADGRB2

451

O60241
CWGSTHPRKASDNEE

SLC4A9

191

Q96Q91
KCGSDWTKAVFSPDR

ATG16L2

546

Q8NAA4
KRCPEAADAGDTRKW

ACTL7B

81

Q9Y614
LDWCRQSGKSPSEVF

ADAT2

81

Q7Z6V5
FKCGSDWTRVVFSPD

ATG16L1

531

Q676U5
DLESRDQAWSPKTCD

FBXO10

296

Q9UK96
DRCSPKEDQAWDGAS

FBXO34

356

Q9NWN3
ATQTPSCWAEEGAEK

GLCCI1

201

Q86VQ1
IGDSWEWRPSKDCSD

ATG10

26

Q9H0Y0
FRSCPTGEKNTDDWE

DNHD1

1396

Q96M86
FKEASGPIWLDDVSC

CD163L1

531

Q9NR16
CTWARPGKAFTDEET

DMWD

626

Q09019
CKFTDVTLSPWSGDS

GRAMD1A

401

Q96CP6
ASPKADAWDVDAIFC

AGBL1

461

Q96MI9
DGSDTSISPGRCKWN

MMP26

86

Q9NRE1
WSKECPIDRSGRVAD

RBM4

171

Q9BWF3
SWCLLESDVSSAPDK

NPFFR2

11

Q9Y5X5
AKRKPEGRSCDDEDW

RAD54L

11

Q92698
GPSGKRWSKDSDCAE

RIC1

1041

Q4ADV7
CIPSAEGRSKAFSTW

OR8B4

226

Q96RC9
TKDSCNDSFRGWAAP

LRRC8A

61

Q8IWT6
WCEDDLSTGAATPRT

MELK

376

Q14680
GKSSCSRVDEVWPNL

DUSP13

31

Q6B8I1
KWEDDSRNHGSPSDC

MOV10L1

101

Q9BXT6
GDNSVWSRAAPECKV

CD46

211

P15529
CLPDSSVAEDKWLSA

MTMR11

326

A4FU01
PWRSTCKAEFEDSDT

GPBP1L1

446

Q9HC44
SSLPWRDLSECEESK

GLP1R

116

P43220
CRSSTPADAWRAEAA

FUT4

106

P22083
DWPAACDLREKLDSF

FRMD8P1

186

Q9BZ68
EDCEDTREVKGPWGS

KCNT1

1041

Q5JUK3
PCADAGSDSTKRSRW

KDM5D

1091

Q9BY66
DKDGAETLTFPCDRW

LOXHD1

1196

Q8IVV2
NPGECLATSEATWKD

C9orf131

531

Q5VYM1
WCQSTEASPKRSDGT

ERAP1

31

Q9NZ08
AKWSGSPCSRNREEA

FOXO4

236

P98177
VDSWSDFRLTSDKPC

PEAK1

1321

Q9H792
TAWRGDCPSAKNDDA

MS4A10

191

Q96PG2
DKSWEEICRASEFPA

DNAH12

2391

Q6ZR08
EWDGESSLSAKEVPC

PLK5

131

Q496M5
AWPDLRTSEEDSKSC

KIAA0408

146

Q6ZU52
SSRCPAAKENGSRWI

LY75

1526

O60449
SGACDASSKLWDIRD

GNB4

201

Q9HAV0
IPADWRCDGTKDCSD

LRP2

41

P98164
SILGKCFDSPWTTRA

LRRC8E

151

Q6NSJ5
WSKECPVDRTGRVAD

RBM4B

171

Q9BQ04
WLDRSLPGATAAECA

EIF4E3

56

Q8N5X7
CADWFLTGSREKTDS

INTU

656

Q9ULD6
WAGSKETCNDRRTPS

BRCA1

321

P38398
ALAWEAPGRSCSEST

DACT2

551

Q5SW24
RFAEEKEWDSEASCP

AVEN

156

Q9NQS1
RKASSRIWDDGDDFC

DHX57

51

Q6P158
ANGKSADCSVEEEPW

SLC1A2

556

P43004
DWSTRKSRDFNEECP

ILK

226

Q13418
ALGKEAACESSTPSW

DIDO1

491

Q9BTC0
PGSRSDSSADCQWLD

MAP3K20

561

Q9NYL2
TGSDDWDTSEKCRAP

INPP5B

586

P32019
LSVRKCPDFSSSGQW

FMO2

111

Q99518
WSCAEKAAQTESPAE

KANK3

406

Q6NY19
EKPRLWHTACASDEG

KLHDC2

316

Q9Y2U9
DSPCSLDKLEADRSW

LAS2

226

Q8IYD9
WDELAASGLPSCDAA

SDR39U1

41

Q9NRG7
AAVFEDCPGWAARKA

CHADL

716

Q6NUI6
HAKCLRLTSEPEGDW

ZMYND8

111

Q9ULU4
ECEIWNSGSASRSDP

PSG11

216

Q9UQ72
FLDDSKSLVCWPSGE

PKD1

3401

P98161
KPDPDVTERCSDGWS

HPX

41

P02790
VKAEASWDSAVHGCP

KIF13B

1221

Q9NQT8
LKDFCTEWPAALDSD

MRPS35

126

P82673
ESDPDWCKTASGHIK

SOX11

36

P35716
KCNRSEATWGRVPSD

UBOX5

291

O94941
KWAPDGSCILTNSAD

WRAP53

176

Q9BUR4
GWDDSDLTEDLPCVK

TMEM132B

146

Q14DG7
GDKLSDPCSSRWDER

NKTR

386

P30414
SAAPCVDEALTWESG

PSD4

361

Q8NDX1
CESSKDETFWRELPS

SHOC1

1346

Q5VXU9
TPIEAWSSGRSLKAC

SIAE

221

Q9HAT2
DSKQLEWPSERTGSC

PRR32

66

B1ATL7
SDEDEPCAISGKWTF

DLC1

526

Q96QB1
DPTSAEVGCDTIWEK

PLA2R1

221

Q13018
KWDPTGNLLASCSDD

TBL1XR1

356

Q9BZK7
SCVLTGPDDSLWDKH

TRIB3

206

Q96RU7
LSGVSAKCAWDDLSR

SUFU

266

Q9UMX1
EECGKAFSWPSSLTE

ZNF728

371

P0DKX0
ANFSASRAACDPWKE

ZNF395

191

Q9H8N7
SRAACDPWKESGDIS

ZNF395

196

Q9H8N7
ECWATSDAESPKLLA

TACC2

1101

O95359
KGEDWETLKSCSPAS

PLCH1

1321

Q4KWH8
DGSWCPIRAEKERSC

PIAS4

401

Q8N2W9
SSFAASLRELEKCGW

SOCS7

386

O14512
SVKHGDEWGEPSRCD

UNKL

251

Q9H9P5
DSEVPSEVKEACTWG

TEX13A

56

Q9BXU3
DEDWSRDVCLESKAP

VPS13B

2791

Q7Z7G8
DGWCLPKTSDELRDT

GTF3C5

436

Q9Y5Q8
GSDTTCWLPNDARRE

ARHGAP21

766

Q5T5U3
DSEVPSEVKEACTWG

TEX13B

56

Q9BXU2
LASKGGWEDCKRSPA

TNRC6B

791

Q9UPQ9
DAKPLCDWSQVSADD

ZAN

46

Q9Y493
PSGWEDCSFDNRIKA

MYO9A

1191

B2RTY4