Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZNF780B ZNF646 ZNF304	2.94e-06	1244	46	13	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZNF780B ZNF646 ZNF304	3.73e-06	1271	46	13	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZNF780B ZNF646 ZNF304	1.17e-05	1412	46	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZNF780B ZNF646 ZNF304	1.67e-05	1459	46	13	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SP1 ZNF668 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZNF780B	3.71e-05	560	46	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SP1 ZNF668 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZNF780B	4.00e-05	566	46	8	GO:0001216
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ZNF462 SP1 SP3 ZNF668 ZNF225 ZNF319 KLF13 KLF9 ZFP64 ZNF780B ZNF646 ZNF304	3.80e-05	1390	46	12	GO:0045944
GeneOntologyBiologicalProcess	extraocular skeletal muscle development	CACNA1S MYOM1	4.85e-05	5	46	2	GO:0002074
Domain	-	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	1.90e-11	679	44	15	3.30.160.60
Domain	zf-C2H2	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	2.53e-11	693	44	15	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	2.58e-11	694	44	15	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	1.22e-10	775	44	15	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	1.26e-10	777	44	15	PS00028
Domain	Znf_C2H2-like	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	1.77e-10	796	44	15	IPR015880
Domain	Znf_C2H2	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	2.07e-10	805	44	15	IPR007087
Domain	ZnF_C2H2	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	2.18e-10	808	44	15	SM00355
Domain	Sp1_fam	SP1 SP3 SP4 KLF13	5.57e-09	10	44	4	IPR030450
Domain	zf-C2H2_6	ZNF668 ZNF225 ZNF780A ZFP64 ZNF780B ZNF646	8.87e-05	314	44	6	PF13912
Pathway	WP_ESTRADIOL_REGULATION_IN_PORTOSINUSOIDAL_VASCULAR_DISEASE	SP1 SP3	4.36e-05	5	30	2	M45554
Pathway	BIOCARTA_TERC_PATHWAY	SP1 SP3	6.53e-05	6	30	2	MM1564
Pathway	BIOCARTA_TERC_PATHWAY	SP1 SP3	6.53e-05	6	30	2	M22047
Pathway	BIOCARTA_TERT_PATHWAY	SP1 SP3	9.13e-05	7	30	2	MM1541
Pathway	BIOCARTA_TERT_PATHWAY	SP1 SP3	1.22e-04	8	30	2	M22015
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	SP1 SP3	6.56e-04	18	30	2	M3430
Pathway	BIOCARTA_CALCINEURIN_PATHWAY	SP1 SP3	6.56e-04	18	30	2	MM1385
Pubmed	Mammalian SP/KLF transcription factors: bring in the family.	SP1 SP3 SP4 KLF13 KLF9	1.68e-10	25	46	5	15820306
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 KDM5D KLF13 PHF23 KLF9 ZFP64 ZNF646	4.30e-10	808	46	12	20412781
Pubmed	Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.	SP1 SP3 SP4	2.17e-09	3	46	3	23540600
Pubmed	Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.	SP1 SP3 SP4	2.17e-09	3	46	3	26967243
Pubmed	Curcumin decreases specificity protein expression in bladder cancer cells.	SP1 SP3 SP4	2.17e-09	3	46	3	18593936
Pubmed	Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.	SP1 SP3 SP4	2.17e-09	3	46	3	21919647
Pubmed	Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.	SP1 SP3 SP4	2.17e-09	3	46	3	11532028
Pubmed	Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.	SP1 SP3 SP4	2.17e-09	3	46	3	7559627
Pubmed	Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.	SP1 SP3 SP4	8.65e-09	4	46	3	15781457
Pubmed	Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.	SP1 SP3 SP4	8.65e-09	4	46	3	27889927
Pubmed	Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.	SP1 SP3 SP4	2.16e-08	5	46	3	12560508
Pubmed	Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.	SP1 SP3 SP4	2.16e-08	5	46	3	20538607
Pubmed	Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.	SP1 SP3 SP4	2.16e-08	5	46	3	10547281
Pubmed	Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.	SP1 SP3 SP4	4.32e-08	6	46	3	16201967
Pubmed	POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.	SP1 SP3 SP4	7.55e-08	7	46	3	12004059
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SP1 CACNA1S SP3 SP4 KDM5D PHF23 ZNF304	1.49e-06	430	46	7	35044719
Pubmed	Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure.	SP1 SP3	1.71e-06	2	46	2	10825178
Pubmed	HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.	SP1 SP3	1.71e-06	2	46	2	31299490
Pubmed	Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells.	SP1 SP3	1.71e-06	2	46	2	19437621
Pubmed	Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.	KLF13 KLF9	1.71e-06	2	46	2	25904015
Pubmed	Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3.	SP1 SP3	1.71e-06	2	46	2	8845379
Pubmed	Expression of Klf9 and Klf13 in mouse development.	KLF13 KLF9	1.71e-06	2	46	2	11335124
Pubmed	Increased SP4 and SP1 transcription factor expression in the postmortem hippocampus of chronic schizophrenia.	SP1 SP4	1.71e-06	2	46	2	25175639
Pubmed	Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.	SP1 SP3	1.71e-06	2	46	2	14766015
Pubmed	Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function.	SP1 SP3	1.71e-06	2	46	2	25538045
Pubmed	Transcriptional control of human CD2AP expression: the role of Sp1 and Sp3.	SP1 SP3	1.71e-06	2	46	2	21604172
Pubmed	Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.	SP3 SP4	1.71e-06	2	46	2	1454515
Pubmed	Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.	SP1 SP3	1.71e-06	2	46	2	21248046
Pubmed	Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.	SP1 SP3	1.71e-06	2	46	2	31164147
Pubmed	Sp1 and Sp3 activate transcription of the human dopamine transporter gene.	SP1 SP3	1.71e-06	2	46	2	15816870
Pubmed	Sp family transcription factors regulate expression of rat D2 dopamine receptor gene.	SP1 SP3	1.71e-06	2	46	2	9628590
Pubmed	Transcriptional activity and Sp 1/3 transcription factor binding to the P1 promoter sequences of the human AbetaH-J-J locus.	SP1 SP3	1.71e-06	2	46	2	17681019
Pubmed	Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice.	SP1 SP3	1.71e-06	2	46	2	37735515
Pubmed	The nuclear abundance of transcription factors Sp1 and Sp3 depends on biotin in Jurkat cells.	SP1 SP3	1.71e-06	2	46	2	14608051
Pubmed	Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis.	SP1 SP4	1.71e-06	2	46	2	23941741
Pubmed	Sp1 and Sp3 Are the Transcription Activators of Human ek1 Promoter in TSA-Treated Human Colon Carcinoma Cells.	SP1 SP3	1.71e-06	2	46	2	26807725
Pubmed	An Sp1/Sp3 binding polymorphism confers methylation protection.	SP1 SP3	1.71e-06	2	46	2	18725933
Pubmed	Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.	SP1 SP3	1.71e-06	2	46	2	15951564
Pubmed	Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium.	SP1 SP3	1.71e-06	2	46	2	9329821
Pubmed	Krüppel-Like Factors 9 and 13 Block Axon Growth by Transcriptional Repression of Key Components of the cAMP Signaling Pathway.	KLF13 KLF9	1.71e-06	2	46	2	33281552
Pubmed	Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene.	SP1 SP3	1.71e-06	2	46	2	22464952
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	ZNF462 EHMT1 SP1 SP3	3.38e-06	77	46	4	19505873
Pubmed	Sp1 and Sp3 Are important regulators of AP-2gamma gene transcription.	SP1 SP3	5.13e-06	3	46	2	12801994
Pubmed	Expression of the human melanocortin-4 receptor gene is controlled by several members of the Sp transcription factor family.	SP1 SP3	5.13e-06	3	46	2	15821099
Pubmed	Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3.	SP1 SP3	5.13e-06	3	46	2	17652716
Pubmed	Regulation of human CETP gene expression: role of SP1 and SP3 transcription factors at promoter sites -690, -629, and -37.	SP1 SP3	5.13e-06	3	46	2	12730302
Pubmed	Expression patterns of SP1 and SP3 during mouse spermatogenesis: SP1 down-regulation correlates with two successive promoter changes and translationally compromised transcripts.	SP1 SP3	5.13e-06	3	46	2	18417714
Pubmed	Activation of the RNA-dependent protein kinase PKR promoter in the absence of interferon is dependent upon Sp proteins.	SP1 SP3	5.13e-06	3	46	2	16339759
Pubmed	Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells.	SP1 SP3	5.13e-06	3	46	2	12694199
Pubmed	Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene.	SP1 SP3	5.13e-06	3	46	2	26162987
Pubmed	KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy.	KLF13 DLL4	5.13e-06	3	46	2	38973459
Pubmed	Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.	SP1 SP3	5.13e-06	3	46	2	14701757
Pubmed	Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.	SP1 SP3	5.13e-06	3	46	2	15118068
Pubmed	Involvement of the GC-rich sequence and specific proteins (Sp1/Sp3) in the basal transcription activity of neurogranin gene.	SP1 SP3	5.13e-06	3	46	2	16677608
Pubmed	Bifunctional properties of peroxisome proliferator-activated receptor gamma1 in KDR gene regulation mediated via interaction with both Sp1 and Sp3.	SP1 SP3	5.13e-06	3	46	2	15111490
Pubmed	Modulation of Bone Morphogenetic Protein (BMP) 2 gene expression by Sp1 transcription factors.	SP1 SP3	5.13e-06	3	46	2	17317039
Pubmed	Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W.	SP1 SP3	5.13e-06	3	46	2	20180024
Pubmed	In vivo footprinting of the human 11beta-hydroxysteroid dehydrogenase type 2 promoter: evidence for cell-specific regulation by Sp1 and Sp3.	SP1 SP3	5.13e-06	3	46	2	11850421
Pubmed	Transcription factors sp1 and sp3 regulate expression of human extracellular superoxide dismutase in lung fibroblasts.	SP1 SP3	5.13e-06	3	46	2	18314536
Pubmed	Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation.	SP1 SP3	5.13e-06	3	46	2	12855685
Pubmed	Murine glypican-4 gene structure and expression; Sp1 and Sp3 play a major role in glypican-4 expression in 3T3-F442A cells.	SP1 SP3	5.13e-06	3	46	2	15297147
Pubmed	Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression.	SP1 SP3	5.13e-06	3	46	2	21554857
Pubmed	Sp1 and Sp3 transcription factors mediate trichostatin A-induced and basal expression of extracellular superoxide dismutase.	SP1 SP3	5.13e-06	3	46	2	15451065
Pubmed	Molecular and functional characterization of the murine ldh2 promoter region: Sp-binding GC-box domains are the key cis-elements regulating ldh2 gene expression during spermatogenesis.	SP1 SP3	5.13e-06	3	46	2	18790003
Pubmed	Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.	SP1 SP3	5.13e-06	3	46	2	30561605
Pubmed	Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.	SP1 SP3	5.13e-06	3	46	2	11274368
Pubmed	Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways.	SP1 SP3	5.13e-06	3	46	2	12378384
Pubmed	The t-PA -7351C>T enhancer polymorphism decreases Sp1 and Sp3 protein binding affinity and transcriptional responsiveness to retinoic acid.	SP1 SP3	5.13e-06	3	46	2	15466927
Pubmed	Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements.	SP1 SP3	5.13e-06	3	46	2	12509426
Pubmed	Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.	SP1 SP3	5.13e-06	3	46	2	36759621
Pubmed	Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells.	SP1 SP3	5.13e-06	3	46	2	16052479
Pubmed	Sp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells.	SP1 SP3	5.13e-06	3	46	2	16529657
Pubmed	Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.	SP1 SP3	5.13e-06	3	46	2	24315822
Pubmed	Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter.	SP1 SP3	5.13e-06	3	46	2	11237613
Pubmed	Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha.	SP1 SP3	5.13e-06	3	46	2	17540780
Pubmed	SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium.	SP1 SP3	5.13e-06	3	46	2	16807381
Pubmed	Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence.	SP1 SP3	5.13e-06	3	46	2	23028678
Pubmed	Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.	SP1 SP3	5.13e-06	3	46	2	19306294
Pubmed	Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.	SP1 SP3	5.13e-06	3	46	2	15247906
Pubmed	Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells.	SP1 SP3	5.13e-06	3	46	2	15482850
Pubmed	IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1.	SP1 SP3	5.13e-06	3	46	2	16760259
Pubmed	Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells.	SP1 SP3	5.13e-06	3	46	2	15777284
Pubmed	Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells.	KLF13 KLF9	5.13e-06	3	46	2	18056793
Pubmed	Involvement of Sp1/Sp3 in the activation of the GATA-1 erythroid promoter in K562 cells.	SP1 SP3	5.13e-06	3	46	2	18195733
Pubmed	Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.	SP1 SP3	5.13e-06	3	46	2	10816575
Pubmed	The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells.	SP1 SP3	5.13e-06	3	46	2	31863909
Pubmed	Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.	SP3 SP4	5.13e-06	3	46	2	15265862
Pubmed	Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.	SP1 SP3	5.13e-06	3	46	2	20091743
Pubmed	Regulation of the varicella-zoster virus ORF3 promoter by cellular and viral factors.	SP1 SP3	5.13e-06	3	46	2	23523134
Pubmed	O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.	SP3 SP4	5.13e-06	3	46	2	26431879
Pubmed	Structural and functional characterization of the mouse tescalcin promoter.	SP1 SP3	5.13e-06	3	46	2	20540995
Pubmed	Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.	SP1 SP3	5.13e-06	3	46	2	22682030
Pubmed	The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.	KLF13 KLF9	5.13e-06	3	46	2	32241200
Pubmed	The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells.	SP1 SP3	5.13e-06	3	46	2	17906119
Pubmed	A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.	SP1 SP3	5.13e-06	3	46	2	24850855
Pubmed	HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity.	SP1 SP3	5.13e-06	3	46	2	15706661
Pubmed	NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes.	SP1 SP3	5.13e-06	3	46	2	16671893
Pubmed	Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.	SP1 SP3	5.13e-06	3	46	2	27060138
Pubmed	Transcriptional regulation of the human CD97 promoter by Sp1/Sp3 in smooth muscle cells.	SP1 SP3	5.13e-06	3	46	2	18329191
Pubmed	Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.	SP1 SP3	5.13e-06	3	46	2	20974858
Cytoband	19q13.2	CAPN12 ZNF225 ZNF780A ZNF780B	2.28e-05	164	46	4	19q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr9q31	ACTL7A ZNF462 TXNDC8	3.59e-04	137	46	3	chr9q31
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF462 ZBTB8A SP1 SP3 ZNF668 SP4 ZNF225 ZNF319 KLF13 ZNF780A KLF9 ZFP64 ZNF780B ZNF646 ZNF304	5.51e-12	718	38	15	28
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP1 SP3 SP4	7.13e-07	9	38	3	755
GeneFamily	Zinc fingers C2H2-type\|Kruppel like factors	KLF13 KLF9	6.44e-04	18	38	2	624
Drug	vinylene	ZNF462 SP1 SP4 ZNF319 KLF13 ZFP64 TRIM17 ZNF304	2.45e-08	245	45	8	CID000006326
Drug	SP 0	SP1 SP3 SP4	8.57e-07	10	45	3	CID002742752
Drug	homocysteic acid	SP1 SP3	1.14e-05	3	45	2	ctd:C007956
Drug	hyperoside	SP1 SP3 SP4	1.42e-05	24	45	3	ctd:C021304
Drug	ADP-ribosylarginine	SP1 SP3 SP4	1.61e-05	25	45	3	CID000126311
Drug	poly(tetramethylene adipate	SP3 SP4	3.81e-05	5	45	2	CID000032794
Disease	forced expiratory volume, traffic air pollution measurement	FBXL17 TXNDC8	1.11e-04	12	39	2	EFO_0004314, EFO_0007908
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN12 CACNA1S	1.04e-03	36	39	2	DOID:11723 (implicated_via_orthology)
Disease	red blood cell density measurement	ZNF462 SP1 SP3 SP4 KLF9	5.80e-03	880	39	5	EFO_0007978
Disease	mosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement	CCL24 BBS12 TXNDC8	9.25e-03	328	39	3	EFO_0008377, EFO_0008378

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPCCMFFVSKRIPEN	CCL24	31	O00175
KERMCRPSFEECDLP	ADAM2	441	Q99965
SCPKPDFICESRFMR	DUSP8	196	Q13202
PECRISAICSPRDSM	DLL4	651	Q9NR61
RPVTRPDCMCDTFDQ	CCDC180	1401	Q9P1Z9
KPFMFDISRIFTCCL	BBS12	306	Q6ZW61
KQFRCPLCEKRFMRS	KLF9	201	Q13886
MDECIPQDRAPRDFC	ZFYVE28	71	Q9HCC9
FQMPSSFACRREPCL	GJC3	161	Q8NFK1
TCPSRPSCSMELFER	KCNK18	216	Q7Z418
DTKFLCPLCMRSRRP	KDM5D	1226	Q9BY66
ICKMCRPRAYIFSDP	FAM86B1	141	Q8N7N1
RCFMFCFIPSRPEEV	FAM221B	296	A6H8Z2
FPPLFMEAFTRRCCE	PRAMEF12	36	O95522
FCAEPKFICEDMSRT	CAPN12	81	Q6ZSI9
CQCPRVESSMPEDRK	CACNA1S	1741	Q13698
AAPRSRDCFFRGPCM	FBXL17	46	Q9UF56
MASPRLGTFCCPTRD	GPR143	1	P51810
EMTAPSPSCAFCRRL	AKNAD1	596	Q5T1N1
KFSCPICEKRFMRSD	KLF13	226	Q9Y2Y9
EVPLCSCRMETPKSR	EHMT1	516	Q9H9B1
PCIFMCARPARTFSI	OR4A4P	251	Q8NGN8
RFECPECSKRFMRSD	SP4	706	Q02446
MRFCSEGDCAISPPR	PSD	6	A5PKW4
FACPECPKRFMRSDH	SP1	686	P08047
LCQERFLCSEMFFKP	ACTL7A	311	Q9Y615
PRDCPENMKCCPFSR	WFDC6	51	Q9BQY6
CPVSEMFARLCPVSE	nan	86	Q6ZQT0
DLPRMRFKCPYCTHV	ZBTB8A	276	Q96BR9
LCPRCGRMFSDPSSF	ZNF668	281	Q96K58
DRPCFVMTASCKSPV	TRAPPC14	366	Q8WVR3
FVCPECSKRFMRSDH	SP3	681	Q02447
MSPPRAFACRDCGKS	ZNF646	611	O15015
MRPFNEVDCFLKSCL	PREX2	646	Q70Z35
NEKPFVCRECEMAFR	ZNF780A	441	O75290
NEKPFVCRECEMAFR	ZNF780B	301	Q9Y6R6
NEKPFVCRECEMAFR	ZNF780B	441	Q9Y6R6
TCYCRKPFAGRPMIE	PHF23	341	Q9BUL5
QFSSKRCGPCKRMFP	TXNDC8	26	Q6A555
FGRRVVTFSCCRMPP	ARHGAP8	31	P85298
RKGSFPCPECREMSP	TRIM17	56	Q9Y577
MREKPFRCDTCGKSF	ZNF225	311	Q9UK10
THSAERPFKCDLCPM	ZNF319	336	Q9P2F9
CPFCPFLTMHRRSIS	ZNF462	441	Q96JM2
RVSPCRRTECMESFP	ZNF304	191	Q9HCX3
TLCMCPERPFTAKAS	TREX2	61	Q9BQ50
RPFKCDFCSFDTKRP	ZFP64	521	Q9NTW7
PPCDITCLESFRDSM	MYOM1	936	P52179