Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium-dependent protein serine/threonine phosphatase regulator activity

RCAN1 RCAN3 RCAN2

1.96e-085263GO:0008597
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 OR10J6P MC2R

1.10e-05884268GO:0004930
GeneOntologyMolecularFunctionolfactory receptor activity

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

1.56e-05431266GO:0004984
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR4D6 OR4D11 CCR8 OR10J5 PTPRH OR4D10 OR4D9 OR10J6P MC2R

3.19e-051353269GO:0004888
GeneOntologyMolecularFunctionprotein phosphatase regulator activity

RCAN1 RCAN3 RCAN2

2.91e-04100263GO:0019888
GeneOntologyMolecularFunctionphosphatase regulator activity

RCAN1 RCAN3 RCAN2

4.17e-04113263GO:0019208
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

1.32e-05432266GO:0050911
GeneOntologyBiologicalProcesscalcium-mediated signaling

DYRK1A CCR8 RCAN1 RCAN3 RCAN2

1.81e-05266265GO:0019722
GeneOntologyBiologicalProcesssensory perception of smell

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

1.99e-05465266GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

2.53e-05485266GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

3.90e-05524266GO:0009593
GeneOntologyBiologicalProcesscalcineurin-NFAT signaling cascade

DYRK1A RCAN1 RCAN2

4.23e-0554263GO:0033173
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

4.96e-05547266GO:0007606
GeneOntologyBiologicalProcesscalcineurin-mediated signaling

DYRK1A RCAN1 RCAN2

5.24e-0558263GO:0097720
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

6.99e-05582266GO:0050906
GeneOntologyBiologicalProcesslocomotion involved in locomotory behavior

RCAN1 RCAN2

2.05e-0417262GO:0031987
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 OR10J6P MC2R

2.23e-041395268GO:0007186
GeneOntologyBiologicalProcessdetection of stimulus

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

2.28e-04722266GO:0051606
GeneOntologyBiologicalProcessshort-term memory

RCAN1 RCAN2

2.58e-0419262GO:0007614
DomainCalcipressin

RCAN1 RCAN3 RCAN2

1.86e-093243PF04847
DomainCalcipressin

RCAN1 RCAN3 RCAN2

1.86e-093243IPR006931
DomainGPCR_Rhodpsn_7TM

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 MC2R

1.50e-05670247IPR017452
Domain7tm_1

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 MC2R

1.61e-05677247PF00001
DomainG_PROTEIN_RECEP_F1_1

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 MC2R

1.74e-05685247PS00237
DomainG_PROTEIN_RECEP_F1_2

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 MC2R

1.84e-05691247PS50262
DomainGPCR_Rhodpsn

OR4D6 OR4D11 CCR8 OR10J5 OR4D10 OR4D9 MC2R

1.85e-05692247IPR000276
DomainOlfact_rcpt

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9

1.23e-04393245IPR000725
DomainNucleotide-bd_a/b_plait

RCAN1 RCAN3 RCAN2

4.25e-03258243IPR012677
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9

2.79e-04389225M14091
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9

3.84e-04417225M4072
Pubmed

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

RCAN1 RCAN3 RCAN2

3.71e-10326317595344
Pubmed

A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).

RCAN1 RCAN3 RCAN2

3.71e-10326310756093
Pubmed

The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes.

RCAN1 RCAN3 RCAN2

3.71e-10326311080588
Pubmed

RCAN 1 and 3 proteins regulate thymic positive selection.

RCAN1 RCAN3 RCAN2

3.70e-09526325783055
Pubmed

Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.

RCAN1 RCAN3 RCAN2

3.70e-09526319819266
Pubmed

Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis.

RCAN1 RCAN2

5.37e-07226217610901
Pubmed

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.

RCAN1 RCAN2

5.37e-07226210722714
Pubmed

Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.

DYRK1A RCAN1

5.37e-07226221965663
Pubmed

CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma.

RCAN1 RCAN2

5.37e-07226237918583
Pubmed

Cooperation to amplify gene-dosage-imbalance effects.

DYRK1A RCAN1

5.37e-07226216919501
Pubmed

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain.

RCAN1 RCAN3

1.61e-06326217767500
Pubmed

Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo.

RCAN1 RCAN2

1.61e-06326216648267
Pubmed

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.

RCAN1 RCAN2

1.61e-06326210861295
Pubmed

RCANs regulate the convergent roles of NFATc1 in bone homeostasis.

RCAN1 RCAN2

1.61e-06326227917924
Pubmed

Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.

RCAN1 RCAN2

1.61e-06326212515860
Pubmed

The human olfactory receptor gene family.

OR4D6 OR4D11 OR10J5 OR4D10 OR4D9 OR10J6P

2.44e-0654126614983052
Pubmed

Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome.

DYRK1A RCAN1

3.22e-06426228172997
Pubmed

Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.

RCAN1 RCAN3 RCAN2

5.88e-064726317198697
Pubmed

Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.

RCAN1 RCAN2

8.05e-06626219136967
Pubmed

Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells.

DYRK1A RCAN1

8.05e-06626224352425
Pubmed

Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner.

DYRK1A RCAN1

8.05e-06626225556111
Pubmed

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

DYRK1A RCAN1

1.13e-05726216554754
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR4D6 OR4D11 OR4D10 OR10J6P

2.05e-0521926412213199
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR4D6 OR4D11 OR10J5 OR4D10

1.13e-0434026411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR4D6 OR4D11 OR10J5 OR4D10

1.13e-0434026411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR4D6 OR4D11 OR10J5 OR4D10

1.17e-0434326432295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR4D6 OR4D11 OR10J5 OR4D10

1.21e-0434626414611657
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

TXNRD1 HELZ2 DYRK1A

1.98e-0415226316009940
Pubmed

Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome.

DYRK1A RCAN1

2.15e-042926223843306
Pubmed

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.

RCAN3 RCAN2

2.31e-043026228077597
Pubmed

Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.

CCR8 RCAN1 RCAN3

3.19e-0417926319074885
InteractionNELL1 interactions

OBSL1 DYRK1A FBLN1

1.26e-0542223int:NELL1
InteractionARMT1 interactions

RCAN1 RCAN3 RCAN2

5.17e-0567223int:ARMT1
InteractionPPP3R1 interactions

RCAN1 RCAN3 RCAN2

5.65e-0569223int:PPP3R1
InteractionPPP3CC interactions

RCAN1 RCAN3 RCAN2

8.15e-0578223int:PPP3CC
Cytoband11q12.1

OR4D6 OR4D11 OR4D10 OR4D9

2.05e-0616126411q12.1
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR4D6 OR4D11 OR4D10 OR4D9

4.11e-05345264chr11q12
Cytoband1q23.2

OR10J5 OR10J6P

1.81e-04352621q23.2
CytobandEnsembl 112 genes in cytogenetic band chr1q23

OR10J5 OR10J6P

7.25e-03226262chr1q23
CytobandEnsembl 112 genes in cytogenetic band chr21q22

DYRK1A RCAN1

1.92e-02377262chr21q22
GeneFamilyOlfactory receptors, family 4

OR4D6 OR4D11 OR4D10 OR4D9

8.82e-06129194151
GeneFamilyOlfactory receptors, family 10

OR10J5 OR10J6P

2.16e-0366192157
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SACS SLC7A14

1.52e-02181192694
CoexpressionKONDO_PROSTATE_CANCER_WITH_H3K27ME3

OR4D11 OR4D10 GYS2 MC2R

3.83e-05194264M7281
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_CYCLING_DC_CELL

TXNRD1 SCFD2 HLTF SHMT1 FBLN1 RCAN1 SACS RCAN3

4.80e-051423268M45722
DiseaseDown syndrome (implicated_via_orthology)

DYRK1A RCAN1 RCAN3 RCAN2

4.57e-1015244DOID:14250 (implicated_via_orthology)
Diseaseserum amyloid P-component measurement

OR10J5 OR10J6P

3.80e-064242EFO_0008283
DiseaseC-C motif chemokine 14 measurement

OR10J5 OR10J6P

2.20e-0427242EFO_0008042
Diseaseinterleukin 12 measurement

DYRK1A SACS

8.52e-0453242EFO_0004753
Diseasegrowth-regulated alpha protein measurement

OR10J5 OR10J6P

9.17e-0455242EFO_0008146
DiseaseAwakening Epilepsy

TXNRD1 DYRK1A

2.02e-0382242C0751111
DiseaseAura

TXNRD1 DYRK1A

2.02e-0382242C0236018
DiseaseEpilepsy, Cryptogenic

TXNRD1 DYRK1A

2.02e-0382242C0086237
DiseaseEpilepsy

TXNRD1 DYRK1A

3.54e-03109242C0014544
Diseaseserum alanine aminotransferase measurement

DYRK1A SHMT1 CCR8 RCAN1

4.96e-03869244EFO_0004735
Diseasemyeloid white cell count

SCFD2 DYRK1A SLC39A12 OR10J5

6.47e-03937244EFO_0007988

Protein segments in the cluster

PeptideGeneStartEntry
RASVHCAHVFTTVSE

GYS2

246

P54840
QVTVETHPVQETTFH

DYRK1A

576

Q13627
LHAATDTTPSVVVHV

RCAN1

201

P53805
HAGTESTPSVVVHVC

RCAN2

151

Q14206
ESTPSVVVHVCESET

RCAN3

191

Q9UKA8
PREHVFVHAITSECV

OBSL1

811

O75147
TSHITVVTLHFVPCI

OR4D11

241

Q8NGI4
TSHMLVVTLHFVPCV

OR4D6

241

Q8NGJ1
TSHITVVTLHFVPCI

OR4D9

241

Q8NGE8
VTCVFDPVHTISHTV

FBLN1

586

P23142
ATHVTEIISFTHCCV

CCR8

281

P51685
CSVVISTHFEVHENA

ENO4

101

A6NNW6
HVTSEHAETSTEVIC

KCMF1

96

Q9P0J7
SLTVPVITHCAHVFC

HLTF

766

Q14527
CEVAVHITDVASFVP

HELZ2

1366

Q9BYK8
VTTTIAILCHEIPHE

SLC39A12

571

Q504Y0
SSCILQITVEEFHHV

SACS

1756

Q9NZJ4
TFATCVSHLTVVIVH

OR10J5

236

Q8NHC4
TFATCAFHLTVVIVH

OR10J6P

236

Q8NGY7
TSHITVVTLHFVPCI

OR4D10

241

Q8NGI6
VPSPFEHCHVVTTTT

SHMT1

241

P34896
CVVVTTVSHAVHLTA

SCFD2

101

Q8WU76
VIFSHHVPTVITFTS

MC2R

166

Q01718
HVSSYTETPVVACIV

SLC7A14

376

Q8TBB6
IHPVCAEVFTTLSVT

TXNRD1

621

Q16881
VSHSVVCHTESAGVI

PTPRH

741

Q9HD43