Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

FHIT NAAA

2.94e-0381202GO:0016811
GeneOntologyMolecularFunctionubiquitin protein ligase binding

FHIT CASC3 HERC2

4.39e-03337203GO:0031625
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

FHIT CASC3 HERC2

5.19e-03358203GO:0044389
GeneOntologyCellularComponentexon-exon junction complex

CASC3 SMG6

1.81e-0421202GO:0035145
GeneOntologyCellularComponentvacuolar lumen

DNAJC3 NCAN NAAA

6.22e-04178203GO:0005775
DomainMib_Herc2

HECTD1 HERC2

6.53e-064202IPR010606
DomainMIB_HERC2

HECTD1 HERC2

6.53e-064202PS51416
DomainMIB_HERC2

HECTD1 HERC2

6.53e-064202PF06701
DomainHECT

HECTD1 HERC2

3.76e-0427202PF00632
DomainHECTc

HECTD1 HERC2

3.76e-0427202SM00119
DomainHECT_dom

HECTD1 HERC2

3.76e-0427202IPR000569
DomainHECT

HECTD1 HERC2

3.76e-0427202PS50237
DomainDnaJ

DNAJC3 DNAJC16

1.19e-0348202PF00226
DomainDnaJ

DNAJC3 DNAJC16

1.24e-0349202SM00271
DomainDNAJ_1

DNAJC3 DNAJC16

1.24e-0349202PS00636
DomainDNAJ_2

DNAJC3 DNAJC16

1.24e-0349202PS50076
Domain-

DNAJC3 DNAJC16

1.24e-03492021.10.287.110
DomainDnaJ_domain

DNAJC3 DNAJC16

1.35e-0351202IPR001623
Domain-

HECTD1 HERC2

2.74e-03732022.60.120.260
Domainzf-C2H2_6

ZNF791 ZNF860 ZNF572

4.34e-03314203PF13912
DomainGalactose-bd-like

HECTD1 HERC2

4.49e-0394202IPR008979
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

MAP1B HECTD1 NBPF1 HERC2 SMG6

8.84e-0651320525798074
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MAP1B PRUNE2 HECTD1 CASC3 DNAJC3 NBPF1 SMG6

1.23e-05148920728611215
Pubmed

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

CASC3 SMG6

4.78e-051820225220460
Pubmed

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

MAP1B CASC3 DNAJC3 HERC2

8.56e-0541820435338135
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HECTD1 HERC2

1.01e-042620226949039
Pubmed

Global landscape of HIV-human protein complexes.

CASC3 DNAJC3 HERC2 SMG6

1.21e-0445720422190034
Pubmed

An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.

HS6ST3 DNAJC3

1.26e-042920211991713
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PRUNE2 DNAJC16 SMG6

2.81e-0422520312168954
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

MAP1B HECTD1 DNAJC3 DNAJC16 NAAA

4.90e-04120120535696571
InteractionKTN1 interactions

HECTD1 DNAJC3 DNAJC16 NCAN HERC2

1.12e-05331195int:KTN1
Cytoband13q32.1

HS6ST3 DNAJC3

2.16e-051620213q32.1
CytobandEnsembl 112 genes in cytogenetic band chr13q32

HS6ST3 DNAJC3

8.02e-0496202chr13q32
CytobandEnsembl 112 genes in cytogenetic band chr14q12

HECTD1 IRF9

9.58e-04105202chr14q12
CytobandEnsembl 112 genes in cytogenetic band chr17p13

GUCY2D SMG6

9.84e-03346202chr17p13
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

DNAJC3 DNAJC16

8.43e-0449162584
GeneFamilyAnkyrin repeat domain containing

HECTD1 ANKFN1

1.89e-02242162403
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF791 ZNF860 ZNF572

2.37e-0271816328
CoexpressionGSE26727_WT_VS_KLF2_KO_LPS_STIM_MACROPHAGE_UP

FHIT IRF9 GUCY2D NAAA

1.42e-05199204M8301
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IRF9 NCAN GUCY2D

3.37e-05142203e5608bbbc04edcdaafe1affc4db7f9d8edba04d9
ToppCellnormal_Lung-B_lymphocytes-Undetermined|normal_Lung / Location, Cell class and cell subclass

PRUNE2 ZNF791 GUCY2D

4.72e-05159203f89fc18966d9b9b33e81e7b9eb3ec3420c20ff43
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B PRUNE2 HS6ST3

7.17e-0518320361a73de857f4ae02dcba3af348f436f602b28ff2
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B HS6ST3 NCAN

7.77e-05188203bd091503f580dedab40e0996273101285d24b586
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1B PRUNE2 HS6ST3

8.79e-051962036b5b7dbcb2cce8a736e44145a01290905876a5e9
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAP1B PRUNE2 HS6ST3

8.79e-051962039830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1B PRUNE2 HS6ST3

8.79e-051962035159d8625d80c20eb28157b2603c8bde9d377a35
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAP1B PRUNE2 HS6ST3

8.92e-05197203ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAP1B PRUNE2 HS6ST3

9.06e-05198203c12e7511628db819a52959bb68580e27c00c2e41
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MAP1B PRUNE2 HS6ST3

9.06e-051982031e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MAP1B PRUNE2 HS6ST3

9.06e-05198203e9f434bfd072e590fe44d518057ee5aa653038f3
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAP1B PRUNE2 HS6ST3

9.33e-05200203a66449b22b39dd6987fc2c3ed160d24564234ced
Diseaseaortic root size

FHIT SMG6

1.01e-0426172EFO_0005037
Diseasecranial vault morphology measurement

PRUNE2 HS6ST3

2.18e-03121172EFO_0009278
Diseaset-tau measurement

FHIT MAP1B

2.36e-03126172EFO_0004760
Diseasemajor depressive disorder

FHIT HS6ST3

3.54e-03155172MONDO_0002009
Diseasesusceptibility to childhood ear infection measurement

FHIT GUCY2D

4.29e-03171172EFO_0007904
Diseasecolorectal health

FHIT HERC2

5.87e-03201172EFO_0008460
Diseaseeye colour measurement

FHIT HERC2

6.87e-03218172EFO_0009764
Diseaseosteoarthritis

FHIT SMG6

7.11e-03222172MONDO_0005178

Protein segments in the cluster

PeptideGeneStartEntry
EKKQHEEFDLSPDQW

SMG6

821

Q86US8
WHPDNFQNEEEKKKA

DNAJC3

421

Q13217
WDTRDKDGFKAQEGP

NOBOX

16

O60393
PEEGDWKNSNLDRHN

MAP1B

191

P46821
EGDRVWLKKFPGDQH

GUCY2D

556

Q02846
TNYDHWKPAPKEDDR

NAAA

286

Q02083
RKADLENHNKDGGFW

HERC2

1211

O95714
WHPDKNKDPGAEDKF

DNAJC16

56

Q9Y2G8
GGHRWDQVKKEDQEA

NBPF1

871

Q3BBV0
QREHRDHQWPKEDGA

HS6ST3

441

Q8IZP7
ELQKHDKEDFPASWR

FHIT

116

P49789
DAKELQQGKPYHWRD

HECTD1

651

Q9ULT8
GRWEHDKFREDEQAP

CASC3

216

O15234
PWKHAGKQDFREDQD

IRF9

41

Q00978
APEIWGKKNNDSRDH

PRUNE2

861

Q8WUY3
KKHPTEDWEKDEGNF

NCAN

1306

O14594
WKDYDDREPRHKGQS

ANKFN1

371

Q8N957
KEEEKPNHQEWDSGE

ZNF572

101

Q7Z3I7
KWEDPNVEDQHKNQG

ZNF791

46

Q3KP31
HLNDKEGQQDLDPWK

TEX33

16

O43247
GKDIHDFEFQWQEDK

ZNF860

106

A6NHJ4