Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC1 ATP13A5 ABCA12 ABCG5	3.04e-05	109	33	4	GO:0042626
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC1 ABCA12 ABCG5	7.19e-05	49	33	3	GO:0140359
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCC1 ABCA12	9.47e-05	9	33	2	GO:0034040
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCC1 ATP13A5 SLC23A2 ABCA12 ABCG5 XPR1	1.15e-04	477	33	6	GO:0022804
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC1 ATP13A5 ABCA12 ABCG5	2.04e-04	178	33	4	GO:0015399
GeneOntologyMolecularFunction	efflux transmembrane transporter activity	ABCC1 XPR1	3.13e-04	16	33	2	GO:0015562
GeneOntologyMolecularFunction	ATP hydrolysis activity	RNF213 ABCC1 ATP13A5 ABCA12 ABCG5	7.32e-04	441	33	5	GO:0016887
GeneOntologyMolecularFunction	telomerase RNA binding	PARN SMG7	7.76e-04	25	33	2	GO:0070034
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	ABCC1 SLC23A2	1.61e-03	36	33	2	GO:0090482
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2E SETD5	2.40e-03	44	33	2	GO:0140938
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	FERMT2 ADAP2	2.97e-03	49	33	2	GO:0005547
GeneOntologyMolecularFunction	ATP-dependent activity	RNF213 ABCC1 ATP13A5 ABCA12 ABCG5	3.15e-03	614	33	5	GO:0140657
GeneOntologyMolecularFunction	lipid transporter activity	ABCC1 ABCA12 ABCG5	4.09e-03	196	33	3	GO:0005319
GeneOntologyMolecularFunction	hexosyltransferase activity	UGT1A1 DPY19L3 UGGT1	5.02e-03	211	33	3	GO:0016758
GeneOntologyMolecularFunction	lipid binding	UGT1A1 PDZD8 C3 PTEN FERMT2 ADAP2	5.08e-03	988	33	6	GO:0008289
GeneOntologyBiologicalProcess	cellular response to ethanol	UGT1A1 PTEN SLC23A2	8.38e-06	25	33	3	GO:0071361
GeneOntologyBiologicalProcess	dendrite extension	AUTS2 PTEN SLC23A2	5.40e-05	46	33	3	GO:0097484
GeneOntologyCellularComponent	Rpd3L-Expanded complex	KMT2E SETD5	2.27e-06	2	32	2	GO:0070210
GeneOntologyCellularComponent	Set3 complex	KMT2E SETD5	2.27e-06	2	32	2	GO:0034967
MousePheno	enlarged cerebellum	PDZD8 PTEN	2.49e-05	4	29	2	MP:0008914
Domain	ABC_TRANSPORTER_2	ABCC1 ABCA12 ABCG5	8.23e-05	48	33	3	PS50893
Domain	ABC_tran	ABCC1 ABCA12 ABCG5	8.23e-05	48	33	3	PF00005
Domain	ABC_TRANSPORTER_1	ABCC1 ABCA12 ABCG5	8.76e-05	49	33	3	PS00211
Domain	ABC_transporter-like	ABCC1 ABCA12 ABCG5	9.31e-05	50	33	3	IPR003439
Domain	AAA+_ATPase	RNF213 ABCC1 ABCA12 ABCG5	1.17e-04	144	33	4	IPR003593
Domain	AAA	RNF213 ABCC1 ABCA12 ABCG5	1.17e-04	144	33	4	SM00382
Domain	SET	KMT2E SETD5	2.38e-03	41	33	2	PF00856
Domain	ABC_transporter_CS	ABCC1 ABCA12	2.49e-03	42	33	2	IPR017871
Domain	SET	KMT2E SETD5	2.98e-03	46	33	2	SM00317
Domain	SET_dom	KMT2E SETD5	3.52e-03	50	33	2	IPR001214
Domain	SET	KMT2E SETD5	3.52e-03	50	33	2	PS50280
Domain	PH	FERMT2 DOCK11 ADAP2	7.57e-03	229	33	3	PF00169
Domain	PH	FERMT2 DOCK11 ADAP2	1.28e-02	278	33	3	SM00233
Domain	PH_DOMAIN	FERMT2 DOCK11 ADAP2	1.29e-02	279	33	3	PS50003
Domain	PH_domain	FERMT2 DOCK11 ADAP2	1.31e-02	280	33	3	IPR001849
Domain	Cadherin_CS	PCDHA7 FAT4	1.58e-02	109	33	2	IPR020894
Domain	Cadherin	PCDHA7 FAT4	1.70e-02	113	33	2	PF00028
Domain	CADHERIN_1	PCDHA7 FAT4	1.70e-02	113	33	2	PS00232
Domain	CADHERIN_2	PCDHA7 FAT4	1.72e-02	114	33	2	PS50268
Domain	-	PCDHA7 FAT4	1.72e-02	114	33	2	2.60.40.60
Pathway	KEGG_ABC_TRANSPORTERS	ABCC1 ABCA12 ABCG5	7.88e-05	44	27	3	M11911
Pubmed	Synergistic repression of thyroid hyperplasia by cyclin C and Pten.	PTEN CCNC	8.73e-07	2	33	2	31331961
Pubmed	No genetic association between ATP binding cassette proteins and Japanese sporadic Alzheimer's disease.	ABCA12 ABCG5	8.73e-07	2	33	2	15980630
Pubmed	Modulation of bilirubin neurotoxicity by the Abcb1 transporter in the Ugt1-/- lethal mouse model of neonatal hyperbilirubinemia.	ABCC1 UGGT1	2.62e-06	3	33	2	28025333
Pubmed	Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters.	UGT1A1 ABCC1	2.62e-06	3	33	2	30334318
Pubmed	Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.	UGT1A1 ABCC1	2.62e-06	3	33	2	31150474
Pubmed	Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants.	AUTS2 SETD5	2.62e-06	3	33	2	30190612
Pubmed	[Role of PTEN protein in multidrug resistance of prostate cancer cells].	ABCC1 PTEN	5.23e-06	4	33	2	18702307
Pubmed	Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells.	UGT1A1 ABCC1	1.31e-05	6	33	2	12951053
Pubmed	Irinotecan pathway genotype analysis to predict pharmacokinetics.	UGT1A1 ABCC1	3.91e-05	10	33	2	12960109
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PDZD8 RNF213 ABCC1 SMG7 PTEN UGGT1 POLR2G	4.79e-05	1049	33	7	27880917
Pubmed	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.	UGT1A1 ABCC1	5.73e-05	12	33	2	19349540
Pubmed	Pharmacogenetic predictors of adverse events and response to chemotherapy in metastatic colorectal cancer: results from North American Gastrointestinal Intergroup Trial N9741.	UGT1A1 ABCC1	6.77e-05	13	33	2	20530282
Pubmed	TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.	AUTS2 PTEN	7.89e-05	14	33	2	27979975
Pubmed	GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.	C3 PTEN	9.10e-05	15	33	2	23345428
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	RNF213 AP3D1 ZMYM4 UGGT1	1.08e-04	262	33	4	36880596
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	PCDHA7 SMG7 PTEN AP3D1	1.67e-04	293	33	4	31741433
Pubmed	Immunomic analysis of human sarcoma.	AUTS2 PDZD8	1.81e-04	21	33	2	12601173
Pubmed	Identification of Modifier Genes in a Mouse Model of Gaucher Disease.	PDZD8 FAT4	1.99e-04	22	33	2	27568557
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	PDZD8 ZMYM4	3.49e-04	29	33	2	21834987
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	AUTS2 RNF213 SMG7 PTEN SETD5 ZMYM4 NPAS2	4.17e-04	1489	33	7	28611215
Pubmed	Role of Tat protein in HIV neuropathogenesis.	PTEN POLR2G	4.53e-04	33	33	2	19526283
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZMYM4 CCNC POLR2G	5.34e-04	167	33	3	20362541
Pubmed	Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.	PTEN POLR2G	5.39e-04	36	33	2	22422068
Pubmed	The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.	CCNC POLR2G	6.33e-04	39	33	2	9121429
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	RNF213 FAT4 FERMT2 AP3D1 XPR1	7.76e-04	777	33	5	35844135
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	UGT1A1 ABCC1 ABCG5	8.12e-04	193	33	3	19343046
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	C3 GABBR2	8.80e-04	46	33	2	37207277
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	CCNC POLR2G	9.19e-04	47	33	2	15175163
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	FERMT2 DOCK11 ADAP2	2.79e-03	206	25	3	682
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sema3c-Inhibitory_Gad1Gad2_Htr3a.Sema3c_(Interneuron,__(candidate_CGE-derived_12))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCDHA7 C3 IFNLR1	8.69e-06	54	33	3	a582a89185bd4c3508a3349e68fca070743e6e75
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sema3c\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCDHA7 C3 IFNLR1	8.69e-06	54	33	3	b1adbf4632694746511e3051d4306a42223cbb92
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sema3c-Inhibitory_Gad1Gad2_Htr3a.Sema3c_(Interneuron,__(candidate_CGE-derived_12))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCDHA7 C3 IFNLR1	8.69e-06	54	33	3	c593dd57c79c770c7939d641dcfaf6c9c0ff5710
Disease	Drug toxicity	UGT1A1 ABCC1 C3	1.04e-04	84	32	3	C0013221
Disease	Adverse reaction to drug	UGT1A1 ABCC1 C3	1.04e-04	84	32	3	C0041755
Disease	syndromic intellectual disability (implicated_via_orthology)	AUTS2 PDZD8	1.35e-04	16	32	2	DOID:0050888 (implicated_via_orthology)
Disease	Blood Platelet Disorders	AP3D1 ABCG5	1.35e-04	16	32	2	C0005818
Disease	Neurodevelopmental Disorders	KMT2E PTEN SETD5	1.41e-04	93	32	3	C1535926
Disease	Autistic Disorder	GABBR2 KMT2E PTEN NPAS2	1.77e-04	261	32	4	C0004352
Disease	Neutropenia	UGT1A1 AP3D1	2.36e-04	21	32	2	C0027947
Disease	pulse pressure measurement	RNF213 PCDHA7 PTEN FERMT2 AP3D1 XPR1 NPAS2	6.10e-04	1392	32	7	EFO_0005763
Disease	prostate cancer (is_marker_for)	KMT2E PTEN SETD5	6.42e-04	156	32	3	DOID:10283 (is_marker_for)
Disease	human immunodeficiency virus infectious disease (is_marker_for)	C3 KMT2E	7.01e-04	36	32	2	DOID:526 (is_marker_for)
Disease	breast cancer (is_marker_for)	KMT2E PTEN SETD5	1.05e-03	185	32	3	DOID:1612 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YPRPLNFKLYSDAFK	ATP13A5	386	Q4VNC0
KPFRKPIYTNYIFSF	ATP13A5	1066	Q4VNC0
IYNFTYKVFFPRKDQ	ABCA12	646	Q86UK0
PVVKFRYFPATSRYA	FAT4	351	Q6V0I7
SPYQIHFTKTPKYFK	C3	351	P01024
LPPYVAYFTRVFQNK	DPY19L3	691	Q6ZPD9
KAKFEARVPAFYYIP	ADAP2	86	Q9NPF8
YKVFLKYPESLRPAF	AP3D1	171	O14617
LKYSPFVVSFRKHYP	ITPKC	396	Q96DU7
SKYITKSFNFYVFPK	PARN	81	O95453
KSFNFYVFPKPFNRS	PARN	86	O95453
SLNPKEFPTYEYIKF	NPAS2	176	Q99743
LKTRFSYAFPKEFPY	CCNC	116	P24863
PRVPFKLVSTFKNYY	PCDHA7	391	Q9UN72
CFLPYSIFKPIFYVL	GPR82	261	Q96P67
IYTFSVPKYSKFSKP	IFNLR1	201	Q8IU57
PNYKIRFKPFFPYQT	PDZD8	286	Q8NEN9
KYPTKVDPFYRHSLF	AUTS2	566	Q8WXX7
KRPYPFVLFYSKFHG	KMT2E	376	Q8IZD2
YLRSFIKYSFRPEKP	DOCK11	911	Q5JSL3
PIPFKIISYFTFQKY	ABCG5	556	Q9H222
ITPPEAKKYFNFRYP	EFHB	286	Q8N7U6
KKKYPYFFRTVPSDN	GABBR2	166	O75899
LLRFKYYSFFDLNPK	FERMT2	271	Q96AC1
YFSPNFKVKLYFTKT	PTEN	336	P60484
PSLFKVLYKTFGPYF	ABCC1	311	P33527
IFYYCRSIAVKFPFP	SMG7	206	Q92540
HFFKKPYPFVLFYSK	SETD5	316	Q9C0A6
VFFLINPTKTFYYKS	XPR1	356	Q9UBH6
DSYRKAIARFFPKPY	RNF213	2701	Q63HN8
VLYPVKYKAIVFRPF	POLR2G	66	P62487
KKYRCFSYLPISPTF	SLC23A2	611	Q9UGH3
GAFYTLKTYPVPFQR	UGT1A1	71	P22309
YSTKMTYLRFFPPLQ	ZMYM4	1416	Q5VZL5
LKNYLSPTFKEFIPY	UGGT1	1291	Q9NYU2