Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	medium-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	2.05e-05	2	91	2	GO:0140981
GeneOntologyMolecularFunction	16-hydroxypalmitate dehydrogenase activity	CYP4A11 CYP4A22	2.05e-05	2	91	2	GO:0103002
GeneOntologyMolecularFunction	ferroxidase activity	CP HEPH	3.04e-04	6	91	2	GO:0004322
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPL ALPG	3.04e-04	6	91	2	GO:0004035
GeneOntologyMolecularFunction	oxidoreductase activity, acting on metal ions, oxygen as acceptor	CP HEPH	3.04e-04	6	91	2	GO:0016724
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4A11 CYP4A22	4.25e-04	7	91	2	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4A11 CYP4A22	4.25e-04	7	91	2	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4A11 CYP4A22	9.03e-04	10	91	2	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	9.03e-04	10	91	2	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4A11 CYP4A22	9.03e-04	10	91	2	GO:0102033
MousePheno	salt-sensitive hypertension	CYP4A11 GATA5 CYP4A22	1.60e-05	10	73	3	MP:0004217
MousePheno	abnormal cerebellar cortex morphology	B4GALT2 IL1RAPL1 SUMF1 CP ZFYVE26 AP4B1 CADPS2 ZIC1 SEMA4C	2.49e-05	300	73	9	MP:0004097
MousePheno	abnormal cerebellum morphology	B4GALT2 IL1RAPL1 SUMF1 CP ZFYVE26 AP4B1 CADPS2 MEGF10 ZIC1 SEMA4C	3.23e-05	389	73	10	MP:0000849
MousePheno	impaired coordination	B4GALT2 EGR2 CP ZFYVE26 DMD CTNND2 AP4B1 CADPS2 VPS13B ALPL ZIC1	3.49e-05	478	73	11	MP:0001405
MousePheno	abnormal metencephalon morphology	B4GALT2 IL1RAPL1 SUMF1 CP ZFYVE26 AP4B1 CADPS2 MEGF10 ZIC1 SEMA4C	6.16e-05	420	73	10	MP:0000847
MousePheno	abnormal cerebellar layer morphology	B4GALT2 IL1RAPL1 SUMF1 CP ZFYVE26 AP4B1 CADPS2 SEMA4C	6.59e-05	263	73	8	MP:0009956
MousePheno	abnormal glial cell morphology	EGR2 SUMF1 AKR1C3 CP ZFYVE26 EML1 DMD HSF1 DHTKD1	7.39e-05	345	73	9	MP:0003634
MousePheno	abnormal motor coordination/balance	B4GALT2 EGR2 AKR1C3 CP ZFYVE26 EML1 DMD CTNND2 AP4B1 BSN CADPS2 VPS13B ALPL ZIC1	1.44e-04	873	73	14	MP:0001516
MousePheno	abnormal hindbrain morphology	B4GALT2 IL1RAPL1 SUMF1 CP ZFYVE26 AP4B1 CADPS2 MEGF10 ZIC1 SEMA4C	2.01e-04	485	73	10	MP:0000841
MousePheno	abnormal heart valve morphology	EGR2 PKD1 DCHS1 GATA5 TNS1 PRRC2B	2.05e-04	163	73	6	MP:0000285
MousePheno	increased renal vascular resistance	CYP4A11 CYP4A22	2.66e-04	5	73	2	MP:0005531
MousePheno	abnormal renal sodium reabsorption	CYP4A11 CYP4A22	2.66e-04	5	73	2	MP:0010109
Domain	CAPS	CADPS CADPS2	2.19e-05	2	88	2	IPR033227
Domain	GATA_N	GATA6 GATA5	6.56e-05	3	88	2	IPR008013
Domain	MULTICOPPER_OXIDASE2	CP HEPH	6.56e-05	3	88	2	PS00080
Domain	Cu-oxidase	CP HEPH	6.56e-05	3	88	2	PF00394
Domain	GATA-N	GATA6 GATA5	6.56e-05	3	88	2	PF05349
Domain	Cu-oxidase	CP HEPH	6.56e-05	3	88	2	IPR001117
Domain	Alk_phosphatase	ALPL ALPG	1.31e-04	4	88	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPL ALPG	1.31e-04	4	88	2	IPR018299
Domain	Alkaline_phosphatase	ALPL ALPG	1.31e-04	4	88	2	IPR001952
Domain	Cu-oxidase_2	CP HEPH	1.31e-04	4	88	2	IPR011706
Domain	REJ	PKD1 PKDREJ	1.31e-04	4	88	2	PS51111
Domain	alkPPc	ALPL ALPG	1.31e-04	4	88	2	SM00098
Domain	REJ_dom	PKD1 PKDREJ	1.31e-04	4	88	2	IPR014010
Domain	ALKALINE_PHOSPHATASE	ALPL ALPG	1.31e-04	4	88	2	PS00123
Domain	Cu-oxidase_2	CP HEPH	1.31e-04	4	88	2	PF07731
Domain	Cu_oxidase_CS	CP HEPH	2.17e-04	5	88	2	IPR033138
Domain	Cu-oxidase_3	CP HEPH	2.17e-04	5	88	2	IPR011707
Domain	DUF1041	CADPS CADPS2	2.17e-04	5	88	2	SM01145
Domain	MULTICOPPER_OXIDASE1	CP HEPH	2.17e-04	5	88	2	PS00079
Domain	Cu-oxidase_3	CP HEPH	2.17e-04	5	88	2	PF07732
Domain	PKD/REJ-like	PKD1 PKDREJ	3.25e-04	6	88	2	IPR002859
Domain	REJ	PKD1 PKDREJ	3.25e-04	6	88	2	PF02010
Domain	Cu_oxidase_Cu_BS	CP HEPH	3.25e-04	6	88	2	IPR002355
Domain	DUF1041	CADPS CADPS2	4.54e-04	7	88	2	PF06292
Domain	Munc13_1	CADPS CADPS2	4.54e-04	7	88	2	IPR014770
Domain	CAPS_dom	CADPS CADPS2	4.54e-04	7	88	2	IPR010439
Domain	MHD1	CADPS CADPS2	4.54e-04	7	88	2	PS51258
Domain	GPS	PKD1 PKDREJ ADGRD1	5.44e-04	34	88	3	SM00303
Domain	GPS	PKD1 PKDREJ ADGRD1	6.99e-04	37	88	3	IPR000203
Domain	PKD_channel	PKD1 PKDREJ	1.17e-03	11	88	2	PF08016
Domain	PKD1_2_channel	PKD1 PKDREJ	1.17e-03	11	88	2	IPR013122
Domain	ZnF_GATA	GATA6 GATA5	1.40e-03	12	88	2	SM00401
Domain	-	CP HEPH	1.93e-03	14	88	2	2.60.40.420
Domain	Znf_GATA	GATA6 GATA5	2.21e-03	15	88	2	IPR000679
Domain	GATA	GATA6 GATA5	2.21e-03	15	88	2	PF00320
Domain	GATA_ZN_FINGER_1	GATA6 GATA5	2.52e-03	16	88	2	PS00344
Domain	GATA_ZN_FINGER_2	GATA6 GATA5	2.52e-03	16	88	2	PS50114
Domain	LH2	PKD1 PKDREJ	3.20e-03	18	88	2	SM00308
Domain	PLAT	PKD1 PKDREJ	4.35e-03	21	88	2	PS50095
Domain	-	PKD1 PKDREJ	4.35e-03	21	88	2	2.60.60.20
Domain	PLAT	PKD1 PKDREJ	4.35e-03	21	88	2	PF01477
Domain	PLAT/LH2_dom	PKD1 PKDREJ	4.35e-03	21	88	2	IPR001024
Domain	Cupredoxin	CP HEPH	4.77e-03	22	88	2	IPR008972
Domain	Claudin_CS	CLDN24 CLDN22	4.77e-03	22	88	2	IPR017974
Domain	CLAUDIN	CLDN24 CLDN22	4.77e-03	22	88	2	PS01346
Domain	Quino_amine_DH_bsu	EML1 BRWD3	4.77e-03	22	88	2	IPR011044
Domain	C2_dom	CADPS PIK3CG CADPS2 TNS1	7.55e-03	164	88	4	IPR000008
Domain	Claudin	CLDN24 CLDN22	7.66e-03	28	88	2	IPR006187
Domain	Alkaline_phosphatase_core	ALPL ALPG	9.34e-03	31	88	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ALPL ALPG	9.34e-03	31	88	2	IPR017849
Domain	-	ALPL ALPG	9.34e-03	31	88	2	3.40.720.10
Pubmed	Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.	CADPS DMD CADPS2	1.73e-08	3	91	3	12659812
Pubmed	Mapping of the azh locus to mouse chromosome 4.	CYP4A11 H6PD CYP4A22	6.92e-08	4	91	3	1552159
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CEP350 TTC7B CADPS HIPK1 TAF1C PKD1 AKR1C3 TNKS RIPK4 CTNND2 CADPS2 METTL26 ZNF785 BRWD3 ALPL	1.19e-06	1285	91	15	35914814
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXN2 HOXB9 MNX1 EGR2 HES7 ZBTB22 GATA6 GATA5 HSF1 ZIC1	1.67e-06	544	91	10	28473536
Pubmed	CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.	CADPS CADPS2	6.77e-06	2	91	2	18177725
Pubmed	Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.	CYP4A11 CYP4A22	6.77e-06	2	91	2	15611369
Pubmed	Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.	CP HEPH	6.77e-06	2	91	2	30060949
Pubmed	Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.	CYP4A11 CYP4A22	6.77e-06	2	91	2	23641057
Pubmed	Characterization of alkaline phosphatase genes expressed in seminoma by cDNA cloning.	ALPL ALPG	6.77e-06	2	91	2	9823315
Pubmed	The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.	CYP4A11 CYP4A22	6.77e-06	2	91	2	28912346
Pubmed	Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.	CYP4A11 CYP4A22	6.77e-06	2	91	2	24413902
Pubmed	Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.	CP HEPH	6.77e-06	2	91	2	22342521
Pubmed	The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.	CP HEPH	6.77e-06	2	91	2	21051716
Pubmed	CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.	CADPS CADPS2	6.77e-06	2	91	2	18022372
Pubmed	Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.	CYP4A11 CYP4A22	6.77e-06	2	91	2	8031839
Pubmed	Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.	CP HEPH	6.77e-06	2	91	2	26303407
Pubmed	Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.	CYP4A11 CYP4A22	6.77e-06	2	91	2	10860550
Pubmed	Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.	CP HEPH	6.77e-06	2	91	2	29355933
Pubmed	Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.	CP HEPH	6.77e-06	2	91	2	27991585
Pubmed	CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.	CADPS CADPS2	6.77e-06	2	91	2	28883501
Pubmed	Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.	CYP4A11 CYP4A22	6.77e-06	2	91	2	11320253
Pubmed	Characterization of the CYP4A11 gene, a second CYP4A gene in humans.	CYP4A11 CYP4A22	6.77e-06	2	91	2	12464262
Pubmed	Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.	CYP4A11 CYP4A22	6.77e-06	2	91	2	15066132
Pubmed	Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.	CADPS CADPS2	6.77e-06	2	91	2	20855507
Pubmed	DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors.	IL1RAPL1 DMD	6.77e-06	2	91	2	18253029
Pubmed	20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.	CYP4A11 CYP4A22	6.77e-06	2	91	2	23825080
Pubmed	CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.	CADPS CADPS2	6.77e-06	2	91	2	18495893
Pubmed	Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.	CYP4A11 CYP4A22	6.77e-06	2	91	2	16691295
Pubmed	The P450 gene superfamily: recommended nomenclature.	CYP4A11 CYP4A22	6.77e-06	2	91	2	3829886
Pubmed	Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.	CP HEPH	6.77e-06	2	91	2	18326691
Pubmed	Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.	CP HEPH	6.77e-06	2	91	2	25788583
Pubmed	Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models.	DMD ALPL	6.77e-06	2	91	2	19151073
Pubmed	Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.	CP HEPH	6.77e-06	2	91	2	15365174
Pubmed	Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.	CYP4A11 CYP4A22	6.77e-06	2	91	2	29277328
Pubmed	Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.	CYP4A11 CYP4A22	6.77e-06	2	91	2	21820496
Pubmed	Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.	CP HEPH	6.77e-06	2	91	2	29883959
Pubmed	Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.	CYP4A11 CYP4A22	6.77e-06	2	91	2	20943934
Pubmed	The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.	CYP4A11 CYP4A22	6.77e-06	2	91	2	2766933
Pubmed	Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.	CYP4A11 CYP4A22	6.77e-06	2	91	2	17112342
Pubmed	CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.	CADPS CADPS2	6.77e-06	2	91	2	25719439
Pubmed	Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.	CP HEPH	6.77e-06	2	91	2	17065470
Pubmed	High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.	CYP4A11 CYP4A22	6.77e-06	2	91	2	30088983
Pubmed	Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.	CP HEPH	6.77e-06	2	91	2	31263155
Pubmed	Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.	CYP4A11 CYP4A22	6.77e-06	2	91	2	19208908
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CEP350 IL1RAPL1 MXRA5 TCF20 SERPINB1 CTNND2 BSN MED17 PRRC2B ZNF687	6.81e-06	638	91	10	31182584
Pubmed	Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.	CYP4A11 CYP4A22	2.03e-05	3	91	2	2354437
Pubmed	Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus.	H6PD ALPL	2.03e-05	3	91	2	2883119
Pubmed	Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.	CYP4A11 CYP4A22	2.03e-05	3	91	2	28270609
Pubmed	Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.	CP HEPH	2.03e-05	3	91	2	23640881
Pubmed	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	CP HEPH	2.03e-05	3	91	2	24988611
Pubmed	Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.	CP HEPH	2.03e-05	3	91	2	18022819
Pubmed	Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain.	CADPS CADPS2	2.03e-05	3	91	2	25437547
Pubmed	H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.	CYP4A11 CYP4A22	2.03e-05	3	91	2	37659685
Pubmed	A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.	CYP4A11 CYP4A22	2.03e-05	3	91	2	9271096
Pubmed	Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.	CP HEPH	2.03e-05	3	91	2	30182051
Pubmed	Selective expression of two homeobox genes in CD34-positive cells from human bone marrow.	HOXB9 MNX1	2.03e-05	3	91	2	1712647
Pubmed	An Alternative Exon of CAPS2 Influences Catecholamine Loading into LDCVs of Chromaffin Cells.	CADPS CADPS2	2.03e-05	3	91	2	30389842
Pubmed	Iron promotes oxidative cell death caused by bisretinoids of retina.	CP HEPH	2.03e-05	3	91	2	29686088
Pubmed	Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells.	GATA6 GATA5	2.03e-05	3	91	2	16162334
Pubmed	Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.	CYP4A11 CYP4A22	2.03e-05	3	91	2	8011168
Pubmed	Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions.	DMD MEGF10	2.03e-05	3	91	2	28498977
Pubmed	Ca2+-dependent activator proteins of secretion promote vesicular monoamine uptake.	CADPS CADPS2	2.03e-05	3	91	2	19008227
Pubmed	Assignment of the perlecan (heparan sulfate proteoglycan) gene to mouse chromosome 4.	H6PD ALPL	2.03e-05	3	91	2	1686572
Pubmed	The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.	CYP4A11 CYP4A22	2.03e-05	3	91	2	1991046
Pubmed	A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.	CADPS CADPS2	2.03e-05	3	91	2	14530279
Pubmed	Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.	GATA6 GATA5	2.03e-05	3	91	2	9566909
Pubmed	Genetics of the Akp-2 locus for alkaline phosphatase of liver, kidney, bone, and placenta in the mouse. Linkage with the Ahd-1 locus on chromosome 4.	H6PD ALPL	2.03e-05	3	91	2	7334202
Pubmed	Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.	CYP4A11 CYP4A22	2.03e-05	3	91	2	19713718
Pubmed	Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.	CYP4A11 CYP4A22	2.03e-05	3	91	2	15313227
Pubmed	Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.	CP HEPH	2.03e-05	3	91	2	35271829
Pubmed	GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development.	GATA6 GATA5	2.03e-05	3	91	2	9119112
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXN2 HOXB9 MNX1 EGR2 HES7 GATA6 KIAA1549 TFDP3 GATA5 HSF1 ZIC1	2.56e-05	908	91	11	19274049
Pubmed	Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.	CADPS CADPS2	4.05e-05	4	91	2	29068313
Pubmed	Mice with hepcidin-resistant ferroportin accumulate iron in the retina.	CP HEPH	4.05e-05	4	91	2	26506980
Pubmed	Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.	CYP4A11 CYP4A22	4.05e-05	4	91	2	8334987
Pubmed	Tight junction-based epithelial microenvironment and cell proliferation.	CLDN24 CLDN22	4.05e-05	4	91	2	19029935
Pubmed	Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.	HOXB9 HES7	4.05e-05	4	91	2	23219549
Pubmed	NR0B1-Related Adrenal Hypoplasia Congenita	IL1RAPL1 DMD	4.05e-05	4	91	2	20301604
Pubmed	Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.	GATA6 GATA5	4.05e-05	4	91	2	16621466
Pubmed	Developmentally regulated Ca2+-dependent activator protein for secretion 2 (CAPS2) is involved in BDNF secretion and is associated with autism susceptibility.	CADPS CADPS2	4.05e-05	4	91	2	19238500
Pubmed	BMP-mediated induction of GATA4/5/6 blocks somitic responsiveness to SHH.	GATA6 GATA5	4.05e-05	4	91	2	25294942
Pubmed	GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations.	GATA6 GATA5	4.05e-05	4	91	2	12944489
Pubmed	Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.	CYP4A11 CYP4A22	4.05e-05	4	91	2	22159897
Pubmed	Identification and mapping of a mouse gene influencing cerebellar folial pattern.	H6PD ALPL	4.05e-05	4	91	2	2400934
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPL ALPG	4.05e-05	4	91	2	9056646
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	CP HEPH	4.05e-05	4	91	2	15354085
Pubmed	The Eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development.	H6PD ALPL	4.05e-05	4	91	2	8183555
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPL ALPG	4.05e-05	4	91	2	12372831
Pubmed	Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung's disease.	PIK3CG ITIH5	4.05e-05	4	91	2	29626357
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	CYP4A11 CYP4A22	4.05e-05	4	91	2	10049703
Pubmed	Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.	GATA6 GATA5	4.05e-05	4	91	2	11375995
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPL ALPG	4.05e-05	4	91	2	9061447
Pubmed	Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice.	CP HEPH	4.05e-05	4	91	2	20811044
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	CYP4A11 CYP4A22	4.05e-05	4	91	2	21161333
Pubmed	Molecular genetic linkage maps of mouse chromosomes 4 and 6.	CYP4A11 ALPL CYP4A22	4.31e-05	26	91	3	1684952
Pubmed	Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.	CADPS2 CCNI ZIC1	6.68e-05	30	91	3	18603407
Pubmed	Central role of pyrophosphate in acellular cementum formation.	ALPL ALPG	6.74e-05	5	91	2	22675556
Pubmed	Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism.	MNX1 EGR2	6.74e-05	5	91	2	17971221
Pubmed	Two alkaline phosphatase genes are expressed during early development in the mouse embryo.	ALPL ALPG	6.74e-05	5	91	2	2133555
Pubmed	Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.	CADPS CADPS2	6.74e-05	5	91	2	22111578
Cytoband	10p14	DHTKD1 ITIH5	1.22e-03	26	91	2	10p14
Cytoband	1p33	CYP4A11 CYP4A22	2.22e-03	35	91	2	1p33
Cytoband	4q35.1	CLDN24 CLDN22	2.34e-03	36	91	2	4q35.1
GeneFamily	Alkaline phosphatases	ALPL ALPG	6.69e-05	4	61	2	1072
GeneFamily	X-linked mental retardation\|Angiotensin receptors	IL1RAPL1 DMD BRWD3	7.59e-04	53	61	3	103
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	GATA6 GATA5	1.14e-03	15	61	2	82
GeneFamily	Claudins	CLDN24 CLDN22	2.71e-03	23	61	2	488
Coexpression	GSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_UP	HDHD3 NUP210 COX6A2 CNDP2 SERPINB1 PGPEP1 SAMHD1	6.38e-06	200	91	7	M9360
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MXRA5 GATA6 PEAK1 HEPH ADGRD1 ITIH5	3.19e-06	197	91	6	2872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCell	LPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BTN3A3 EGR2 TAF1C ZBTB22 TMC8	7.94e-06	133	91	5	2ec3490cbf60152c3cece95eb566d749c9666517
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IL1RAPL1 TTC7B CADPS KIAA1549 TNS1	1.52e-05	152	91	5	32634195048858ae84605c61e43c542d90f7cab5
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IL1RAPL1 TTC7B CADPS KIAA1549 TNS1	1.52e-05	152	91	5	0eb185b2404f015efff1bd140e0c502d714720fb
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIK3CG TMC8 MED12L SAMHD1 DHTKD1	1.67e-05	155	91	5	9f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCell	Basal_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	MXRA5 PAK5 HES7 CP LGR6	1.94e-05	160	91	5	b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL1RAPL1 MXRA5 CP SAMHD1 ITIH5	2.52e-05	169	91	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	facs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COX6A2 MED12L CTNND2 TNS1 SEMA4C	3.07e-05	176	91	5	74f851a398c7562dd713bc0d8d488c0037243112
ToppCell	facs-Marrow-T_cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COX6A2 MED12L CTNND2 TNS1 SEMA4C	3.07e-05	176	91	5	31b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCell	droplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COX6A2 KIAA1549 CTNND2 TNS1 SEMA4C	3.32e-05	179	91	5	d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HOXB9 EGR2 AKR1C3 CLDN22 ZNF844	3.89e-05	185	91	5	25781cf68e693e97dc1885e2879ab24fa946b51e
ToppCell	droplet-Lung-nan-21m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDHD3 CP GATA5 H6PD TNS1	4.76e-05	193	91	5	ac4270b26f5dc7ff2220a109e5aae5a113893211
ToppCell	droplet-Lung-nan-21m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDHD3 CP GATA5 H6PD TNS1	4.76e-05	193	91	5	7a09739d0b07dcd615cce2da93fd169cc92e566d
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	EGR2 NUP210 RIPK4 DMD CTNND2	4.87e-05	194	91	5	c5ef4ff73b4e51530656002e3a2fb7264cdf533d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 GATA6 CP DMD ADGRD1	4.87e-05	194	91	5	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 GATA6 CP DMD ADGRD1	4.99e-05	195	91	5	3c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCell	Bronchial-NucSeq-Stromal-Schwann-Schwann_Myelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL1RAPL1 EGR2 AP4B1 ITIH5 SEMA4C	5.12e-05	196	91	5	efeb272bc9e37e60d15d056b7574991c5c7501bc
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Astrocyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AIFM3 AKR1C3 CTNND2 HEPH MEGF10	5.24e-05	197	91	5	5bcf963f21d23edafef1e90dc1de24cd3b0fccce
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AIFM3 AKR1C3 CTNND2 HEPH MEGF10	5.24e-05	197	91	5	bd7e18a0fed085cfb8ed0e478d1f172a173febbe
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AIFM3 AKR1C3 CTNND2 HEPH MEGF10	5.24e-05	197	91	5	7e06aee2add54eeff4a9927d9b04b5797160113b
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	FBXL17 PEAK1 DMD CADPS2 VPS13B	5.37e-05	198	91	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	FBXL17 TNKS DMD CADPS2 VPS13B	5.50e-05	199	91	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PIK3CG CADPS2 TNS1 MEGF10	1.60e-04	133	91	4	840e8240db29cd21ed9830843c0fa6d65b8f300a
ToppCell	Basal_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	MNX1 RIPK4 LGR6 ZNF785	2.87e-04	155	91	4	30accc72a6a914ae0c4d52b373ea1c9a98efbf22
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IL1RAPL1 GATA5 LGR6 DMD	2.87e-04	155	91	4	cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	IL1RAPL1 CADPS DMD CTNND2	3.16e-04	159	91	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IL1RAPL1 CADPS KIAA1549 TNS1	3.16e-04	159	91	4	ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	IL1RAPL1 CADPS KIAA1549 TNS1	3.16e-04	159	91	4	7b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCell	Club_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SCNN1D CP CTNND2 ALPG	3.24e-04	160	91	4	b261a3a49c850d92bc9e04fc3527c752dfe37a1a
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	COX6A2 MED12L CP HEPH	3.31e-04	161	91	4	3e5a125a25d55bf27652f456239b00b315d54d91
ToppCell	PND01-03-samps-Myeloid-Macrophage-macrophage-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EGR2 PIK3CG CNDP2 SERPINB1	3.31e-04	161	91	4	5925ee646aa040550e3f8a164a13c8a5c0353319
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 COX6A2 SAMHD1 MEGF10	3.39e-04	162	91	4	d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 GATA6 SAMHD1 DMD	3.39e-04	162	91	4	5f009b231f21861afee9cc0c569082e1135f929c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 CP DMD HEPH	3.39e-04	162	91	4	68c40d12689cc1b6c797e6e48173f0110f8144e4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 COX6A2 SAMHD1 MEGF10	3.39e-04	162	91	4	5bbd7130d4dad9035e73a439dda568195c136f31
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 COX6A2 SAMHD1 MEGF10	3.39e-04	162	91	4	eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 GATA6 SAMHD1 DMD	3.39e-04	162	91	4	b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 COX6A2 SAMHD1 MEGF10	3.39e-04	162	91	4	e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 CP DMD HEPH	3.39e-04	162	91	4	735fa3f77b31a4189e431d05c326403c18cbbffb
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	IL1RAPL1 CADPS DMD CTNND2	3.47e-04	163	91	4	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TTC7B BRCA1 TAF1C ZFYVE26	3.47e-04	163	91	4	9f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCell	PND01-03-samps-Myeloid-Macrophage\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EGR2 PIK3CG CNDP2 SERPINB1	3.55e-04	164	91	4	49733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTC7B CADPS MED12L KIAA1549	3.64e-04	165	91	4	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTC7B CADPS MED12L KIAA1549	3.64e-04	165	91	4	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TTC7B CADPS MED12L KIAA1549	3.64e-04	165	91	4	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 DMD CTNND2 MEGF10	3.72e-04	166	91	4	f742d15b02a6f651bbd00f53e3d871f40d05a03d
ToppCell	TCGA-Colorectal\|World / Sample_Type by Project: Shred V9	HOXB9 MNX1 AIFM3 HEPH	3.72e-04	166	91	4	c018cd8c7a82251c67e3dc812d4d21e527a43456
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 DMD CTNND2 MEGF10	3.72e-04	166	91	4	0f013bb5fdb72e88c2fc73d60cd01551a2db6341
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 DMD CTNND2 MEGF10	3.72e-04	166	91	4	e941df9a1091164edde3def8fc7d410186b2bd88
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 DMD CTNND2 MEGF10	3.72e-04	166	91	4	aeda46bea5d8463c24a83b98b9ed92d962d733e5
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a6.Nell1_(Neuron.Slc17a6.Nell1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	IGFN1 LGR6 FAM187A	3.81e-04	69	91	3	11e6747ed4a45acee210c48ba670bfe0375fb19b
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a6.Nell1_(Neuron.Slc17a6.Nell1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	IGFN1 LGR6 FAM187A	3.81e-04	69	91	3	96564b46008a6e5220b6596cbbe0a24e9b5955ee
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	COX6A2 DCHS1 MED12L CP	3.89e-04	168	91	4	6501495b7ad252af330b18011696c43031541018
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IL1RAPL1 SAMHD1 CTNND2 MEGF10	3.89e-04	168	91	4	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PIK3CG HIPK1 LRP3 ZFYVE26	3.89e-04	168	91	4	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIAA1549 PGPEP1 H6PD ALPL	3.89e-04	168	91	4	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	TTC7B CADPS MED12L KIAA1549	3.98e-04	169	91	4	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 CP SAMHD1 DMD	4.07e-04	170	91	4	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BTN3A3 PIK3CG TMC8 LGR6	4.07e-04	170	91	4	28fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GATA6 CP SAMHD1 DMD	4.07e-04	170	91	4	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BTN3A3 PIK3CG TMC8 LGR6	4.07e-04	170	91	4	239cb4b801b2d71a6facb386f2684c0851504151
ToppCell	Control-Mast_cells-Mast_cells\|Control / group, cell type (main and fine annotations)	TTC7B CADPS MED12L KIAA1549	4.07e-04	170	91	4	c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell	facs-Heart-LV-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMC8 SERPINB1 CACNA1I RIPK4	4.16e-04	171	91	4	c6fc9ef9735dbf5314a4c7dac2b2954b0985ae4d
ToppCell	facs-Heart-LV-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMC8 SERPINB1 CACNA1I RIPK4	4.16e-04	171	91	4	55b194a9bf4d3e4b5d96e0d1298424359c441cbb
ToppCell	Immune-mast_cell\|World / Lineage, Cell type, age group and donor	CADPS TMC8 MED12L KIAA1549	4.25e-04	172	91	4	6e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCell	COVID-19-Heart-Neuronal\|Heart / Disease (COVID-19 only), tissue and cell type	IL1RAPL1 SAMHD1 CTNND2 MEGF10	4.35e-04	173	91	4	6fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell	TCGA-Breast-Solid_Tissue_Normal\|TCGA-Breast / Sample_Type by Project: Shred V9	PAK5 DMD TNS1 ITIH5	4.44e-04	174	91	4	e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MXRA5 CLDN22 SAMHD1 CTNND2	4.44e-04	174	91	4	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAMHD1 DMD MEGF10 ITIH5	4.44e-04	174	91	4	667035a11b68745fa8446d6c68214713be42710f
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	IL1RAPL1 CADPS KIAA1549 CACNA1I	4.44e-04	174	91	4	64d13a7a9757e85f4f4af876c687dd18a7efa01a
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	PAK5 DMD TNS1 ITIH5	4.44e-04	174	91	4	0f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCell	10x5'-GI_small-bowel-Mast\|GI_small-bowel / Manually curated celltypes from each tissue	IL1RAPL1 CADPS KIAA1549 TNS1	4.44e-04	174	91	4	e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCell	10x5'-GI_small-bowel-Mast-Mast_cells\|GI_small-bowel / Manually curated celltypes from each tissue	IL1RAPL1 CADPS KIAA1549 TNS1	4.44e-04	174	91	4	05525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	PAK5 DMD TNS1 ITIH5	4.44e-04	174	91	4	1aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 CADPS PEAK1 MEGF10	4.54e-04	175	91	4	1b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COX6A2 CTNND2 TNS1 SEMA4C	4.64e-04	176	91	4	d4075796c38b775fe721abb47426e662a0d415e3
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL1RAPL1 BRCA1 DMD SEMA4C	4.64e-04	176	91	4	a8875b4ba4abf6625cdeb67bf544ce1573c59060
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 GATA6 TNKS DMD	4.64e-04	176	91	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRCA1 CP DHTKD1 TNS1	4.64e-04	176	91	4	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IL1RAPL1 GATA5 LGR6 DMD	4.74e-04	177	91	4	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	droplet-Limb_Muscle-nan-21m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 IL1RAPL1 CLDN22 CADPS2	4.74e-04	177	91	4	291231b1520c135e92739e201495fe1935efa927
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLDN22 RIPK4 LGR6 ALPL	4.84e-04	178	91	4	b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCell	10x5'-GI_large-bowel-Mast\|GI_large-bowel / Manually curated celltypes from each tissue	IL1RAPL1 CADPS SERPINB1 TNS1	4.84e-04	178	91	4	d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell	LA-17._Lymphocyte\|World / Chamber and Cluster_Paper	PIK3CG NUP210 TMC8 KIAA1549	4.84e-04	178	91	4	34ec499d03cc198cfefa19a724d4c81974052f65
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLDN22 RIPK4 LGR6 ALPL	4.84e-04	178	91	4	fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCell	10x5'-GI_large-bowel-Mast-Mast_cells\|GI_large-bowel / Manually curated celltypes from each tissue	IL1RAPL1 CADPS SERPINB1 TNS1	4.84e-04	178	91	4	8fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXB9 MNX1 CADPS AIFM3	4.94e-04	179	91	4	d70791d2a0db35a6b013fa7ed2f9f39364581eff
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL1RAPL1 MXRA5 DMD CTNND2	4.94e-04	179	91	4	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COX6A2 CTNND2 TNS1 SEMA4C	5.05e-04	180	91	4	64f01494a4052186773720e10b4e7c724ff94547
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EGR2 GATA6 AIFM3 ITIH5	5.05e-04	180	91	4	39ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCell	RA-16._Neuronal\|RA / Chamber and Cluster_Paper	IL1RAPL1 SAMHD1 MEGF10 ITIH5	5.05e-04	180	91	4	5842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCell	Club-club-8\|World / Class top	CP CLDN22 LGR6 ITIH5	5.26e-04	182	91	4	8111d917e588008d947021460ddf8f1e7ae1337a
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP H6PD PEAK1 TNS1	5.26e-04	182	91	4	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CP H6PD PEAK1 TNS1	5.26e-04	182	91	4	19c5e3a9d9b3728303b682102e276adfe93aa759
ToppCell	(00)_Basal-(0)_uninjured\|(00)_Basal / shred by cell type and Timepoint	CP LGR6 TNS1 ALPL	5.26e-04	182	91	4	c02c9cab4389d80f318f4bb8d703c1e719672624
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CP H6PD PEAK1 TNS1	5.26e-04	182	91	4	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DCHS1 GATA6 TNS1 HEPH	5.26e-04	182	91	4	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DCHS1 GATA6 TNS1 HEPH	5.26e-04	182	91	4	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	metastatic_Lymph_Node-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	TTC7B RPN2 AIFM3 CADPS2	5.26e-04	182	91	4	27d1688fdfc570cedd233aa7030bce7d9b604d42
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	KIAA1549 RIPK4 LGR6 TNS1	5.26e-04	182	91	4	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
Disease	biological sex	CLYBL CADPS FBXL17 PEAK1 MEGF10 ZIC1	6.68e-05	230	88	6	PATO_0000047
Disease	brain edema (implicated_via_orthology)	CP DMD	1.31e-04	6	88	2	DOID:4724 (implicated_via_orthology)
Disease	X-14939 measurement	CYP4A11 CYP4A22	1.31e-04	6	88	2	EFO_0800747
Disease	Autistic Disorder	IL1RAPL1 EGR2 PIK3CG TAF1C CP CADPS2	1.34e-04	261	88	6	C0004352
Disease	disease recurrence, response to allogeneic hematopoietic stem cell transplant, donor genotype effect measurement	PAK5 ADGRD1	1.83e-04	7	88	2	EFO_0004952, EFO_0007044, EFO_0007892
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	CYP4A11 CYP4A22	4.75e-04	11	88	2	DOID:0110861 (biomarker_via_orthology)
Disease	tetralogy of Fallot (is_implicated_in)	GATA6 GATA5	6.71e-04	13	88	2	DOID:6419 (is_implicated_in)
Disease	body surface area	EEF1AKMT4 HES7 PGPEP1 SAMHD1 H6PD CADPS2 ZNF844 ZIC1	6.77e-04	643	88	8	EFO_0022196
Disease	ventricular septal defect (is_implicated_in)	GATA6 GATA5	7.82e-04	14	88	2	DOID:1657 (is_implicated_in)
Disease	sporadic amyotrophic lateral sclerosis	SUMF1 ZFYVE26 CTNND2 ADGRD1	8.31e-04	140	88	4	EFO_0001357
Disease	Abnormal behavior	PRR12 MED12L	1.03e-03	16	88	2	C0233514
Disease	Tetralogy of Fallot	GATA6 GATA5	1.03e-03	16	88	2	C0039685
Disease	Tourette syndrome, schizophrenia	TCF20 CACNA1I	1.30e-03	18	88	2	EFO_0004895, MONDO_0005090
Disease	susceptibility to childhood ear infection measurement	NUP210 CTNND2 BSN VPS13B	1.74e-03	171	88	4	EFO_0007904
Disease	post-traumatic stress disorder symptom measurement	PIK3CG FBXL17 PGPEP1	1.91e-03	82	88	3	EFO_0008535
Disease	ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)	GATA6 GATA5	1.95e-03	22	88	2	C1843687
Disease	mental or behavioural disorder	TCF20 PGPEP1 DMD CTNND2	2.05e-03	179	88	4	EFO_0000677
Disease	severe acute respiratory syndrome, COVID-19	IL1RAPL1 MXRA5 CADPS NUP210 DMD CADPS2	2.23e-03	447	88	6	EFO_0000694, MONDO_0100096
Disease	pallidum volume	TNKS ALPL	2.52e-03	25	88	2	EFO_0006933
Disease	Neonatal diabetes mellitus	MNX1 GATA6	2.52e-03	25	88	2	C0158981

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFSRFSARGPAHALH	B4GALT2	41	O60909
AACSSHAPLALGHYA	CLDN24	186	A6NM45
NATDGSHIYTFPHAS	BTN3A3	476	O00478
QDHPGFQVLASASHY	ADGRD1	31	Q6QNK2
KTVNSSHYRFPAHGQ	ADGRD1	391	Q6QNK2
SPRAYQGNGTARHFH	AIFM3	36	Q96NN9
RNLHYFNSDSFASHP	AKR1C3	301	P42330
RGTAAFYHHLPAASG	CCNI	301	Q14094
RQILHSLPGHFSSHY	AP4B1	301	Q9Y6B7
AQHSHAFLPFSGGSR	CYP4A11	441	Q02928
SRFGHIFPSSAYQHI	BRWD3	156	Q6RI45
RLGVTSHGHYPASFS	FAM187A	356	A6NFU0
AHRDFGPASQHFLST	DMD	3041	P11532
TSSVDLYFGAHHPLH	DHTKD1	266	Q96HY7
RASYSSQHGHLGPEL	CTNND2	396	Q9UQB3
AADIPRLGYSSSSHH	CLYBL	26	Q8N0X4
AAAAAAAAAYNPHHL	EGR2	301	P11161
QSHSFPNYGLSHGLT	HDHD3	56	Q9BSH5
TRQPAAYAESASHFH	KIAA1549	216	Q9HCM3
NLASRPYTFHSHGIT	CP	111	P00450
TLPHSNGGNANSHYF	MEGF10	911	Q96KG7
ASAFKTHPQGHSYNS	PAK5	301	Q9P286
RASPGHSPHYFAASS	NUP210	1846	Q8TEM1
YSFAFCASHVHGNRP	CADPS	751	Q9ULU8
NDHAPSFTLSHYRVA	DCHS1	2476	Q96JQ0
FASGTSYHLPLAHHI	MED12L	816	Q86YW9
RHHLGFYIANSEGLS	ITIH5	821	Q86UX2
HLSHIPGQAFSGLYS	LGR6	101	Q9HBX8
HLFSPQGSSRHAAAY	HIPK1	1131	Q86Z02
DHFPYSNGASVHAAS	MNX1	366	P50219
SSQKRGPARHSYHDY	BSN	3606	Q9UPA5
SRQFSLEHVHGSGPY	HSF1	226	Q00613
ATAHPDLRSTFHNTY	IL1RAPL1	601	Q9NZN1
SLYQSHGRSAFVHVP	PGPEP1	156	Q9NXJ5
TSSPYHAGNLLQRHF	PEAK1	876	Q9H792
AYHARARSAGHGFNA	LRP3	346	O75074
DLSYRSAGSLFPHHG	MED17	206	Q9NVC6
EGSNLTPAHHYNAFR	PIPSL	71	A2A3N6
GQYASSRQPGHAEHL	HOXB9	31	P17482
QHASPAGAYAHTVNR	ALPG	171	P10696
HATPSAAYAHSADRD	ALPL	171	P05186
SPFTHTHLAQGYRRG	BRCA1	1191	P38398
AACSSHAPLASGHYA	CLDN22	186	Q8N7P3
PRQAAYADSGSFLHA	GATA5	11	Q9BWX5
SSLSAARPLNGTYHH	GATA6	311	Q92908
ALCTFNSYLHSGHRP	COX6A2	41	Q02221
PRDGAYAAASSSQHL	FBXL17	86	Q9UF56
IDNLSGSIFHHYSSP	CACNA1I	1821	Q9P0X4
AQHSHAFLPFSGGSR	CYP4A22	441	Q5TCH4
YREIHGAPSNFSSSH	CEP350	131	Q5VT06
YSFAFCASHVHGNRP	CADPS2	716	Q86UW7
KRSYGNAFHHPSAVR	FOXN2	271	P32314
HPFLFFIRHNSSGSI	SERPINB1	356	P30740
VPLHYAVFTRSSAHG	IGFN1	1071	Q86VF2
SQFRAPSHIYGGHSS	EML1	771	O00423
ASRAQFFLHLSPSHY	EMC1	286	Q8N766
RGHSFSFHGAALTAP	H6PD	56	O95479
SPAARAQLFSALHGY	HES7	111	Q9BYE0
ARQFRTFHHPTYGSC	SCNN1D	436	P51172
DPAGSYHLNLSSHFR	PKD1	2986	P98161
SGSGQHAAHFARAFP	METTL26	36	Q96S19
NGHLSSLGTRDTHPY	MRPS5	46	P82675
SHNRFEHSLGVGYLA	SAMHD1	161	Q9Y3Z3
FGVPHQYSSRQVAHS	OGA	391	O60502
FHPSSALLAVRSDYH	TAF1C	301	Q15572
LSHPHFTTLYRGSIN	PKDREJ	1266	Q9NTG1
FKNNASRPYSVHAHG	HEPH	826	Q9BQS7
SALSAYQHPASFGSR	PRR12	146	Q9ULL5
AAQPRHAGAYHCFSE	SEMA4C	616	Q9C0C4
SDGYTALHLAARNGH	RIPK4	716	P57078
SAAPHFRTRHYAQAY	EEF1AKMT4	176	P0DPD7
QRPGAHGSSAAAHRY	SUMF1	56	Q8NBK3
VSDFSHPHYLAGRRA	CNDP2	386	Q96KP4
TSVAADFYHRLGPHH	PIK3CG	81	P48736
IGQRALHYLGSHAFS	TMC8	586	Q8IU68
SLLGHAYGQSHRSPH	SPEM2	351	Q0P670
ASAAAVLSHNRYHVP	RPN2	256	P04844
EGRHSTPLHFAAGYN	TNKS	681	O95271
YESASRAGPAHAGHT	TNS1	561	Q9HBL0
SGHSPYALERAAHAS	PRRC2B	1486	Q5JSZ5
SAYHANTRAHAYGDP	TCF20	1061	Q9UGU0
FRAASNHASPNESAY	TFDP3	141	Q5H9I0
AFGSPNSLYEHRRTH	ZNF844	261	Q08AG5
SQAPGYAAAAALGHH	ZIC1	66	Q15915
SYHHSFQSRGRPHTG	ZNF563	151	Q8TA94
RAHSLSPTDHQAAFY	TTC7B	506	Q86TV6
DTYLPNSRLAGHSTH	VPS13B	3546	Q7Z7G8
FKSGPSAHAHLYSQH	ZNF687	801	Q8N1G0
QHRASYSHLSSNPLF	ZFYVE26	1666	Q68DK2
HRAVLAASSPYFHDQ	ZBTB22	71	O15209
FSYPSLLASHQRVHS	ZNF785	181	A8K8V0
PGSYNRIHSHSTFHL	MXRA5	1766	Q9NR99