Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

PANK2 CAMKK1 TRPM7 DGKB SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 RSKR EPHA8

7.29e-077095812GO:0016773
GeneOntologyMolecularFunctionprotein serine kinase activity

CAMKK1 TRPM7 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 RSKR

9.54e-07363589GO:0106310
GeneOntologyMolecularFunctionkinase activity

PANK2 CAMKK1 TRPM7 DGKB SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 RSKR EPHA8

1.60e-067645812GO:0016301
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

PANK2 POLR1A CAMKK1 TRPM7 DGKB SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 RSKR EPHA8

2.20e-069385813GO:0016772
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CAMKK1 TRPM7 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 RSKR

5.15e-06446589GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

CAMKK1 TRPM7 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 RSKR EPHA8

7.92e-066005810GO:0004672
GeneOntologyMolecularFunctionN-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity

B3GALT2 B3GALT1

5.37e-0412582GO:0008499
GeneOntologyMolecularFunctionbeta-1,3-galactosyltransferase activity

B3GALT2 B3GALT1

8.50e-0415582GO:0048531
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

TRPC4AP FEM1A HERPUD1

1.75e-0382583GO:1990756
DomainKinase-like_dom

CAMKK1 TRPM7 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 EPHA8

4.71e-05542599IPR011009
DomainPROTEIN_KINASE_ATP

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 EPHA8

9.25e-05459598PS00107
DomainSer/Thr_kinase_AS

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10

1.28e-04357597IPR008271
DomainS_TKc

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10

1.32e-04359597SM00220
DomainPROTEIN_KINASE_ST

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10

1.39e-04362597PS00108
DomainProt_kinase_dom

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 EPHA8

1.43e-04489598IPR000719
DomainPROTEIN_KINASE_DOM

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10 EPHA8

1.51e-04493598PS50011
DomainProtein_kinase_ATP_BS

CAMKK1 SRPK1 OXSR1 ULK1 EIF2AK2 CDK10 EPHA8

1.84e-04379597IPR017441
DomainPkinase

CAMKK1 SRPK1 OXSR1 ULK1 MAPK9 EIF2AK2 CDK10

1.91e-04381597PF00069
DomainGlyco_trans_31

B3GALT2 B3GALT1

1.14e-0316592IPR002659
DomainGalactosyl_T

B3GALT2 B3GALT1

1.14e-0316592PF01762
DomainARM-type_fold

DOCK1 TRPC4AP RICTOR FRYL TANGO6

4.30e-03339595IPR016024
DomainDeath

UNC5A EDARADD

4.86e-0333592PF00531
DomainDeath_domain

UNC5A EDARADD

6.41e-0338592IPR000488
DomainDEATH_DOMAIN

UNC5A EDARADD

6.41e-0338592PS50017
PathwayREACTOME_TRP_CHANNELS

TRPC4AP TRPC7 TRPM7

7.65e-0528423MM14943
PathwayREACTOME_TRP_CHANNELS

TRPC4AP TRPC7 TRPM7

7.65e-0528423M27241
PathwayWP_LACTO_SERIES_SPHINGOLIPID_METABOLISM

B3GALT2 B3GALT1

1.29e-046422M46444
PathwayKEGG_MEDICUS_REFERENCE_BLOOD_GROUP_H_O_ANTIGEN_TYPE_1_BIOSYNTHESIS

B3GALT2 B3GALT1

1.29e-046422M47959
PathwayREACTOME_NETRIN_1_SIGNALING

DOCK1 UNC5A TRPC7

2.99e-0444423M875
PathwayBIOCARTA_AMAN_PATHWAY

B3GALT2 B3GALT1

3.08e-049422MM1535
Pubmed

Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.

B3GALT2 B3GALT1

3.03e-0626129417100
Pubmed

Developmental regulation of beta-1,3-galactosyltransferase-1 gene expression in mouse brain.

B3GALT2 B3GALT1

9.07e-06361212633872
Pubmed

Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.

TICAM1 EIF2AK2

1.81e-05461222315398
Pubmed

Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3.

UNC5A DPY19L1

1.81e-05461228202721
Pubmed

Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes.

B3GALT2 B3GALT1

1.81e-0546129417047
Pubmed

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

B3GALT2 B3GALT1

1.81e-0546129582303
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RAP1GAP SAMD9L SLC4A8 RICTOR HERPUD1 MOV10 TANGO6

2.48e-0549361715368895
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DOCK1 SRPK1 RICTOR FRYL CNOT1

2.87e-0520261533005030
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

AHI1 PANK2 MIB1 CNOT1 MOV10 EPHA8

3.93e-0535861632460013
Pubmed

The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors.

TICAM1 EIF2AK2

4.52e-05661219028691
Pubmed

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells.

TICAM1 EIF2AK2

4.52e-05661217190817
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

POLR1A TOPBP1 SRPK1 RFC3 ZC3H7B EIF2AK2 CNOT1 MOV10

5.26e-0575961835915203
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

DOCK1 POLR1A TOPBP1 RFC3 CNOT1 MOV10

6.31e-0539061617643375
Pubmed

Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death.

C9 MAPK9

6.32e-05761219864026
Pubmed

Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein.

B3GALT2 B3GALT1

6.32e-05761218565761
Pubmed

Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages.

TICAM1 MAPK9

6.32e-05761223426369
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

GIPC1 PANK2 DGKB SRPK1 FRYL OXSR1 ULK1 EIF2AK2 CNOT1 MOV10

7.38e-051284611017353931
Pubmed

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

TICAM1 EIF2AK2

8.42e-05861215029200
Pubmed

The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.

TRPC4AP FEM1A

1.35e-041061229779948
Pubmed

The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.

TRPC7 TRPM7

1.35e-041061227177420
Pubmed

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.

TICAM1 EIF2AK2

1.35e-041061221703541
Pubmed

Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.

EIF2AK2 SNX19 ALOX12B

1.80e-046261317975119
Pubmed

Gene variants associated with ischemic stroke: the cardiovascular health study.

EIF2AK2 SNX19 ALOX12B

1.89e-046361319023099
Pubmed

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.

POLR1A MIB1 OXSR1 RFC3 CNOT1

1.91e-0430261530561431
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

POLR1A OXSR1 RFC3 ZC3H7B EIF2AK2 CNOT1 MOV10

2.28e-0470461729955894
Pubmed

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.

RICTOR ULK1

2.33e-041361221795849
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

GIPC1 PLCZ1 DGKB SRPK1 OXSR1 ULK1 CDK10

2.85e-0473061734857952
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SAMD9L UNC93A LRRC70 MAPK9 TEKT5 CNOT1 DNAH14

2.99e-0473661729676528
Pubmed

Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.

DOCK1 HECTD4 RICTOR EXOC8

3.06e-0418361431932471
Pubmed

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

TICAM1 ULK1

3.13e-041561229056340
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MIB1 HECTD4 TOPBP1 OXSR1 ZC3H7B CNOT1

3.29e-0452961614621295
Pubmed

Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.

ULK1 MAPK9 CDK10

3.56e-047861317192257
Pubmed

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

B3GALT2 B3GALT1

3.57e-041661210580128
Pubmed

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly.

ULK1 EXOC8

4.05e-041761221241894
Pubmed

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .

TICAM1 EIF2AK2

4.05e-041761212609980
Pubmed

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

TICAM1 EIF2AK2

4.55e-041861222541070
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

CAMKK1 SRPK1 ZC3H7B EIF2AK2 CDK10

4.96e-0437261522939624
Pubmed

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

ULK1 EXOC8

5.63e-042061225127057
Pubmed

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression.

EIF2AK2 MOV10

6.22e-042161235232816
Pubmed

Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.

HECTD4 MOV10

6.22e-042161225249183
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DPY19L1 ADGRL1 FRYL

7.35e-0410061310048485
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC5A DGKB ADGRL1 ULK1 SNX19

7.44e-0440761512693553
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SLC4A8 DGKB ULK1

7.57e-041016139872452
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FSIP2 RAP1GAP PANK2 CAMKK1 TRPM7 RICTOR FRYL

7.59e-0486161736931259
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPC7 TRPM7

8.15e-042461233884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPC7 TRPM7

8.84e-042561216382100
Pubmed

A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.

EIF2AK2 TSFM

8.84e-042561235211260
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RAP1GAP SRPK1 RICTOR ULK1 ZC3H7B EXOC8

9.67e-0465061638777146
Pubmed

An introduction to TRP channels.

TRPC7 TRPM7

1.03e-032761216460286
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

POLR1A CAMKK1 DPY19L1 SRPK1 ULK1 MAPK9 CDK10

1.05e-0391061736736316
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

POLR1A HECTD4 RICTOR RFC3 MOV10

1.05e-0344061534244565
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DOCK1 TRPC4AP POLR1A HECTD4 ADGRL1 FRYL OXSR1 CNOT1 DNAH14

1.10e-03148961928611215
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GIPC1 POLR1A TOPBP1 SRPK1 RICTOR ZC3H7B TEKT5 EIF2AK2 MOV10

1.14e-03149761931527615
Pubmed

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

TICAM1 EIF2AK2

1.19e-032961221266579
Pubmed

TopBP1 controls BLM protein level to maintain genome stability.

MIB1 TOPBP1

1.19e-032961224239288
Pubmed

SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.

RICTOR EIF2AK2

1.28e-033061234780058
Pubmed

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.

SRPK1 ZC3H7B MOV10

1.28e-0312161334029587
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

DPY19L1 TRPM7 SNX19 HERPUD1 LCLAT1

1.38e-0346861531056421
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

GIPC1 SRPK1 ZC3H7B EIF2AK2

1.52e-0328161424163370
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPC7 TRPM7

1.54e-033361219834762
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

TICAM1 MIB1 EIF2AK2 MOV10

1.56e-0328361421903422
InteractionUBXN6 interactions

RICTOR OXSR1 RFC3 ZC3H7B FEM1A EIF2AK2 MOV10 TANGO6

5.88e-06325618int:UBXN6
GeneFamilyBeta 3-glycosyltransferases

B3GALT2 B3GALT1

1.15e-0324382426
GeneFamilyTransient receptor potential cation channels

TRPC7 TRPM7

1.57e-0328382249
Diseasepancreatitis

HECTD4 ABCG8

4.63e-0416592EFO_0000278
Diseasefeeling nervous measurement

TRPC4AP ZC3H7B DNAH14

7.14e-0487593EFO_0009597
DiseaseAdenocarcinoma of lung (disorder)

ULK1 EIF2AK2 ALOX12B EPHA8

7.78e-04206594C0152013
DiseaseInfiltrating duct carcinoma of female breast

TRPM7 EPHA8

8.05e-0421592C3165106
Diseasecholesterol to total lipids in small LDL percentage

HERPUD1 ABCG8

1.34e-0327592EFO_0022241

Protein segments in the cluster

PeptideGeneStartEntry
KCLLDDDLVLGVYIH

AHI1

336

Q8N157
LCLEGVHLYLLLVEV

ADGRL1

941

O94910
LHLEDVYVGLCLRKL

B3GALT1

261

Q9Y5Z6
KILGELPEHCAYIII

ABCG8

496

Q9H221
LLGCRHYEVARLLKE

GIPC1

186

O14908
LIYSGKLLLDHQCLR

HERPUD1

56

Q15011
ILREVLEGLEYLHKN

OXSR1

126

O95747
VLRLAQLIIEYLLHC

DZIP1L

86

Q8IYY4
HAKRAYRELVLLKCV

MAPK9

66

P45984
LRDVILGLEYLHCQK

CAMKK1

256

Q8N5S9
LEIIELACYRLLHKQ

LCLAT1

391

Q6UWP7
ILIDRIAGFIIKHIC

FSIP2

4571

Q5CZC0
LHKLVLGKYGALVIC

TSFM

226

P43897
AGPCLEYLLQHKILE

FHIP2B

76

Q86V87
RYRELLEIKCHLENG

PDZD4

356

Q76G19
KHLIVAIGVKVYLCL

CWF19L2

686

Q2TBE0
LAELELCRRLYKLHF

FRYL

2826

O94915
GYIDICKLRKIIYIH

DPY19L1

276

Q2PZI1
AELVLVLCYLHDLGI

RSKR

211

Q96LW2
LLHYILKIVVRESCI

HECTD4

406

Q9Y4D8
LRIEGATLLYIHKLC

EXOC8

446

Q8IYI6
KLGFHYEDIIICLRL

RICTOR

76

Q6R327
VVTCYLLLLLHKEIL

LRRC70

16

Q7Z2Q7
VCYDLERIKLLQRGH

MIB1

341

Q86YT6
LDELDCLIKGILYID

PANK2

336

Q9BZ23
RLHLEDVYVGICLAK

B3GALT2

336

O43825
EHEICYLLLVRKNVT

IDI2

146

Q9BXS1
CQLLSHILEVLYRKD

DOCK1

881

Q14185
LYALGLILAELLHVC

EIF2AK2

471

P19525
KCIVLQVLRGLQYLH

CDK10

141

Q15131
VLLLLLICKKRHCGY

EPHA8

556

P29322
AIILHLLYLLEKVEC

FEM1A

496

Q9BSK4
EVIHLKDIVCYLSLL

DGKB

131

Q9Y6T7
TKAILGALLILYVHC

DNAH14

1066

Q0VDD8
GALLILYVHCRDIVI

DNAH14

1071

Q0VDD8
LYVHCRDIVINLLLK

DNAH14

1076

Q0VDD8
LGELIIIRLHKERYA

ALOX12B

61

O75342
ELCRLYHRADVEKVL

EDARADD

181

Q8WWZ3
LLLALLHVYRALCEE

CD226

6

Q15762
LKRHELCGDYIKDIL

HHIPL2

91

Q6UWX4
GVELKDIKRCLGYHL

C9

371

P02748
LLEVRGRLYELLTHC

RFC3

271

P40938
GYLQRCIIKHLEGLV

POLR1A

986

O95602
CIIKHLEGLVVQYDL

POLR1A

991

O95602
LKRGLLEHILYCIVD

TRPC4AP

556

Q8TEL6
YEVKLRLLLHLEELQ

MOV10

336

Q9HCE1
RLLEKLDIRCSYIHV

PLCZ1

26

Q86YW0
RIIHPLIALYCLKEL

SAMD9L

986

Q8IVG5
LKYDVIGDQEHLRLL

RAP1GAP

116

P47736
LECLYHREKRIGIDL

TEKT5

191

Q96M29
ICIIFIYEAIEKLIH

SLC4A8

601

Q2Y0W8
VLQGLDYLHTKCRII

SRPK1

196

Q96SB4
AETIIKDCLYLIHIG

CYB5R4

206

Q7L1T6
LLRYRECHLLVLKAL

CNOT1

1681

A5YKK6
VARLYHLLAEEKLCP

TICAM1

96

Q8IUC6
CVHVKLYILLGVLSL

UNC93A

406

Q86WB7
VLKDLYHLLKHVVCL

TANGO6

1041

Q9C0B7
LINRHLIYCLGDIIL

SNX19

946

Q92543
LVLILVYCRKKEGLD

UNC5A

321

Q6ZN44
IDYCHLIEKLGGLVI

TOPBP1

1281

Q92547
LAHPRIKLEGLCYER

THEGL

346

P0DJG4
IYKEDTVLHLCLREI

TRPM7

1661

Q96QT4
EGCVPRYHKALLLLE

ULK1

1001

O75385
EYEIVHILLLKGARI

TRPC7

176

Q9HCX4
YREGLEHKCKRDILL

ZC3H7B

441

Q9UGR2