Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	7.94e-07	5	87	3	GO:0030156
GeneOntologyMolecularFunction	glucagon receptor activity	GLP1R GCGR	5.61e-05	3	87	2	GO:0004967
GeneOntologyBiologicalProcess	response to peptide hormone	CYBB WNT1 GLP1R LTA4H GCGR CTNNB1 SH2B2 ADCY6 CRHR2 SLC22A12 CRY1	1.25e-05	530	86	11	GO:0043434
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GPR6 ABCA1 GLP1R RIC8A GCGR ADCY6 CRHR2 GABBR1	2.58e-05	286	86	8	GO:0007188
GeneOntologyBiologicalProcess	embryonic pattern specification	SATB2 NCKAP1 WNT1 TDRD6 CTNNB1	3.93e-05	91	86	5	GO:0009880
GeneOntologyBiologicalProcess	astrocyte-dopaminergic neuron signaling	WNT1 CTNNB1	5.14e-05	3	86	2	GO:0036520
GeneOntologyBiologicalProcess	embryonic axis specification	NCKAP1 WNT1 TDRD6 CTNNB1	6.55e-05	52	86	4	GO:0000578
GeneOntologyBiologicalProcess	glial cell-neuron signaling	WNT1 CTNNB1	1.03e-04	4	86	2	GO:0150098
GeneOntologyCellularComponent	Cul3-RING ubiquitin ligase complex	ZSWIM8 KBTBD6 KLHL15 KBTBD7	2.06e-05	39	87	4	GO:0031463
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	2.12e-04	28	87	3	GO:0002177
Domain	WD40_repeat_CS	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	1.24e-05	164	88	7	IPR019775
Domain	Homeobox	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	1.46e-05	234	88	8	PF00046
Domain	HOMEOBOX_1	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	1.55e-05	236	88	8	PS00027
Domain	HOX	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	1.60e-05	237	88	8	SM00389
Domain	HOMEOBOX_2	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	1.70e-05	239	88	8	PS50071
Domain	Homeobox_dom	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	1.70e-05	239	88	8	IPR001356
Domain	GPCR_2_GLP1/glucagon_rcpt	GLP1R GCGR	2.19e-05	2	88	2	IPR003290
Domain	-	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	5.67e-05	283	88	8	1.10.10.60
Domain	-	KBTBD6 ATRNL1 KLHL15 KBTBD7	7.64e-05	48	88	4	2.120.10.80
Domain	Kelch-typ_b-propeller	KBTBD6 ATRNL1 KLHL15 KBTBD7	1.31e-04	55	88	4	IPR015915
Domain	Leuk-A4-hydro_C	AOPEP LTA4H	1.31e-04	4	88	2	PF09127
Domain	Peptidase_M1_C	AOPEP LTA4H	1.31e-04	4	88	2	IPR015211
Domain	Leuk-A4-hydro_C	AOPEP LTA4H	1.31e-04	4	88	2	SM01263
Domain	Homeodomain-like	TGIF1 HOXB5 SATB2 TGIF2 HOXD4 CERS3 POU6F1 CERS4	1.71e-04	332	88	8	IPR009057
Domain	HormR	GLP1R GCGR CRHR2	2.16e-04	25	88	3	SM00008
Domain	WD40	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	2.22e-04	259	88	7	PF00400
Domain	WD40	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	2.73e-04	268	88	7	SM00320
Domain	WD40_repeat	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	2.99e-04	272	88	7	IPR001680
Domain	HRM	GLP1R GCGR CRHR2	3.04e-04	28	88	3	PF02793
Domain	Sec23/24_helical_dom	SEC23B SEC23A	3.25e-04	6	88	2	IPR006900
Domain	Sec23_24_beta_S	SEC23B SEC23A	3.25e-04	6	88	2	IPR012990
Domain	zf-Sec23_Sec24	SEC23B SEC23A	3.25e-04	6	88	2	PF04810
Domain	Sec23_trunk	SEC23B SEC23A	3.25e-04	6	88	2	PF04811
Domain	Sec23_helical	SEC23B SEC23A	3.25e-04	6	88	2	PF04815
Domain	Sec23_BS	SEC23B SEC23A	3.25e-04	6	88	2	PF08033
Domain	Sec23/24_trunk_dom	SEC23B SEC23A	3.25e-04	6	88	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC23B SEC23A	3.25e-04	6	88	2	IPR006895
Domain	Lag1/Lac1	CERS3 CERS4	3.25e-04	6	88	2	IPR016439
Domain	Kelch_1	KBTBD6 ATRNL1 KLHL15 KBTBD7	3.33e-04	70	88	4	PF01344
Domain	Kelch_1	KBTBD6 ATRNL1 KLHL15 KBTBD7	3.33e-04	70	88	4	IPR006652
Domain	WD_REPEATS_1	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	3.41e-04	278	88	7	PS00678
Domain	WD_REPEATS_2	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	3.48e-04	279	88	7	PS50082
Domain	WD_REPEATS_REGION	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	3.48e-04	279	88	7	PS50294
Domain	WD40_repeat_dom	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	5.07e-04	297	88	7	IPR017986
Domain	GPCR_2_secretin-like_CS	GLP1R GCGR CRHR2	5.44e-04	34	88	3	IPR017983
Domain	G-protein_beta_WD-40_rep	FBXW10B FBXW10 MLST8 WDSUB1	6.97e-04	85	88	4	IPR020472
Domain	SH3_2	RIMBP3 MACC1 RIMBP3C RIMBP3B	7.28e-04	86	88	4	IPR011511
Domain	SH3_2	RIMBP3 MACC1 RIMBP3C RIMBP3B	7.28e-04	86	88	4	PF07653
Domain	G_PROTEIN_RECEP_F2_1	GLP1R GCGR CRHR2	8.80e-04	40	88	3	PS00649
Domain	GPCR_2_extracellular_dom	GLP1R GCGR CRHR2	8.80e-04	40	88	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	GLP1R GCGR CRHR2	8.80e-04	40	88	3	PS50227
Domain	-	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	9.92e-04	333	88	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	1.03e-03	335	88	7	IPR015943
Domain	ARM-type_fold	PIK3C2B AOPEP ASPM LTA4H RIC8A CTNNB1 KPNA3	1.10e-03	339	88	7	IPR016024
Domain	Peptidase_M1	AOPEP LTA4H	1.40e-03	12	88	2	IPR001930
Domain	Homeobox_antennapedia	HOXB5 HOXD4	1.40e-03	12	88	2	IPR017995
Domain	Peptidase_M1	AOPEP LTA4H	1.66e-03	13	88	2	PF01433
Domain	Peptidase_M1_N	AOPEP LTA4H	1.66e-03	13	88	2	IPR014782
Domain	G_PROTEIN_RECEP_F2_2	GLP1R GCGR CRHR2	1.69e-03	50	88	3	PS00650
Domain	7tm_2	GLP1R GCGR CRHR2	1.69e-03	50	88	3	PF00002
Domain	Gelsolin	SEC23B SEC23A	1.93e-03	14	88	2	PF00626
Domain	Gelsolin-like_dom	SEC23B SEC23A	1.93e-03	14	88	2	IPR007123
Domain	TLC	CERS3 CERS4	2.52e-03	16	88	2	PS50922
Domain	TLC	CERS3 CERS4	2.52e-03	16	88	2	SM00724
Domain	TRAM_LAG1_CLN8	CERS3 CERS4	2.52e-03	16	88	2	PF03798
Domain	TLC-dom	CERS3 CERS4	2.52e-03	16	88	2	IPR006634
Domain	Kelch	KBTBD6 KLHL15 KBTBD7	2.59e-03	58	88	3	SM00612
Domain	BACK	KBTBD6 KLHL15 KBTBD7	2.85e-03	60	88	3	SM00875
Domain	GPCR_2_secretin-like	GLP1R GCGR CRHR2	2.85e-03	60	88	3	IPR000832
Domain	GPCR_2-like	GLP1R GCGR CRHR2	2.85e-03	60	88	3	IPR017981
Domain	Homeobox_KN	TGIF1 TGIF2	2.85e-03	17	88	2	PF05920
Domain	Homeobox_KN_domain	TGIF1 TGIF2	2.85e-03	17	88	2	IPR008422
Domain	BACK	KBTBD6 KLHL15 KBTBD7	2.99e-03	61	88	3	PF07707
Domain	BACK	KBTBD6 KLHL15 KBTBD7	2.99e-03	61	88	3	IPR011705
Domain	G_PROTEIN_RECEP_F2_4	GLP1R GCGR CRHR2	2.99e-03	61	88	3	PS50261
Domain	Homeobox_Antennapedia_CS	HOXB5 HOXD4	4.35e-03	21	88	2	IPR001827
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C TDRD6 RIMBP3B	3.76e-08	14	88	4	17662146
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	6.25e-08	4	88	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.56e-07	5	88	3	17855024
Pubmed	Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure.	CTNNB1 SEC23B SEC23A	2.55e-06	11	88	3	19966784
Pubmed	WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.	SATB2 ASPM TDRD6 PCNT	2.64e-06	38	88	4	34059773
Pubmed	The Wnt/β-catenin pathway attenuates experimental allergic airway disease.	WNT1 CTNNB1	6.33e-06	2	88	2	24929002
Pubmed	Modulation of β-catenin signaling by glucagon receptor activation.	GCGR CTNNB1	6.33e-06	2	88	2	22438981
Pubmed	Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease.	WNT1 CTNNB1	6.33e-06	2	88	2	30477246
Pubmed	Wnt signaling behaves as a "master regulator" in the osteogenic and adipogenic commitment of human amniotic fluid mesenchymal stem cells.	WNT1 CTNNB1	6.33e-06	2	88	2	23605563
Pubmed	Association of Wnt1/beta-catenin with clinical pathological characteristics and prognosis of esophageal squamous cell carcinoma.	WNT1 CTNNB1	6.33e-06	2	88	2	20491588
Pubmed	Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.	GLP1R GCGR	6.33e-06	2	88	2	27226600
Pubmed	Inactivation of nuclear Wnt-beta-catenin signaling limits blastocyst competency for implantation.	WNT1 CTNNB1	6.33e-06	2	88	2	18199579
Pubmed	Cloning and functional characterization of mammalian homologues of the COPII component Sec23.	SEC23B SEC23A	6.33e-06	2	88	2	8898360
Pubmed	Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis.	WNT1 CTNNB1	6.33e-06	2	88	2	20404086
Pubmed	Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.	WNT1 CTNNB1	6.33e-06	2	88	2	16756720
Pubmed	Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells.	WNT1 CTNNB1	6.33e-06	2	88	2	19725118
Pubmed	Role of 5'TG3'-interacting factors (TGIFs) in Vorinostat (HDAC inhibitor)-mediated Corneal Fibrosis Inhibition.	TGIF1 TGIF2	6.33e-06	2	88	2	26330748
Pubmed	Impact of an altered Wnt1/β-catenin expression on clinicopathology and prognosis in clear cell renal cell carcinoma.	WNT1 CTNNB1	6.33e-06	2	88	2	23708097
Pubmed	Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo.	SEC23B SEC23A	6.33e-06	2	88	2	30065114
Pubmed	The effect on cell growth by Wnt1 RNAi in human neuroblastoma SH-SY5Y cell line.	WNT1 CTNNB1	6.33e-06	2	88	2	19756656
Pubmed	Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery.	GLP1R GCGR	6.33e-06	2	88	2	33920024
Pubmed	Wnt/β-catenin pathway promotes acute lung injury induced by LPS through driving the Th17 response in mice.	WNT1 CTNNB1	6.33e-06	2	88	2	29246763
Pubmed	Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells.	WNT1 CTNNB1	6.33e-06	2	88	2	21781302
Pubmed	Wnt/beta-catenin signaling activates and determines hepatic zonal expression of glutathione S-transferases in mouse liver.	WNT1 CTNNB1	6.33e-06	2	88	2	20118494
Pubmed	Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy.	WNT1 CTNNB1	6.33e-06	2	88	2	15888552
Pubmed	Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).	GLP1R GCGR	6.33e-06	2	88	2	9105899
Pubmed	Overexpression of GLP-1 receptors suppresses proliferation and cytokine release by airway smooth muscle cells of patients with chronic obstructive pulmonary disease via activation of ABCA1.	ABCA1 GLP1R	6.33e-06	2	88	2	28560433
Pubmed	Clinicopathological, immunohistochemical, and mutational analyses of pulmonary enteric adenocarcinoma: usefulness of SATB2 and β-catenin immunostaining for differentiation from metastatic colorectal carcinoma.	SATB2 CTNNB1	6.33e-06	2	88	2	28438615
Pubmed	The ups and downs of Wnt signaling in prevalent neurological disorders.	WNT1 CTNNB1	6.33e-06	2	88	2	17143299
Pubmed	ASPM regulates Wnt signaling pathway activity in the developing brain.	ASPM CTNNB1	6.33e-06	2	88	2	21937711
Pubmed	Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone.	WNT1 CTNNB1	6.33e-06	2	88	2	16908522
Pubmed	MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumors.	WNT1 CTNNB1	6.33e-06	2	88	2	19225568
Pubmed	Wnt signaling controls the phosphorylation status of beta-catenin.	WNT1 CTNNB1	6.33e-06	2	88	2	11834740
Pubmed	Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/β-catenin signaling in human osteosarcoma cells.	WNT1 CTNNB1	6.33e-06	2	88	2	27665868
Pubmed	Effects on hepatic lipid metabolism in human hepatoma cells following overexpression of TGFβ induced factor homeobox 1 or 2.	TGIF1 TGIF2	6.33e-06	2	88	2	30825648
Pubmed	Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking.	GLP1R GCGR	6.33e-06	2	88	2	25451942
Pubmed	Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for 19 F-NMR studies in solution.	GLP1R GCGR	6.33e-06	2	88	2	33369025
Pubmed	Localization of a (CA)n repeat in glucagon-like peptide-1 receptor gene (Glp1r) to proximal mouse chromosome 17 and its linkage to other markers.	GLP1R GCGR	6.33e-06	2	88	2	7613039
Pubmed	Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment.	WNT1 CTNNB1	6.33e-06	2	88	2	24481453
Pubmed	Wnt/beta-catenin inhibits dental pulp stem cell differentiation.	WNT1 CTNNB1	6.33e-06	2	88	2	18218837
Pubmed	Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.	GLP1R GCGR	6.33e-06	2	88	2	23203689
Pubmed	Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice.	GLP1R GCGR	6.33e-06	2	88	2	19602537
Pubmed	Aberrant Wnt1/β-catenin expression is an independent poor prognostic marker of non-small cell lung cancer after surgery.	WNT1 CTNNB1	6.33e-06	2	88	2	21336184
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	6.33e-06	2	88	2	31400758
Pubmed	Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair.	WNT1 CTNNB1	6.33e-06	2	88	2	22085926
Pubmed	Wnt/β-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum.	WNT1 CTNNB1	6.33e-06	2	88	2	21857982
Pubmed	Wnt and beta-catenin signaling target the expression of ecto-5'-nucleotidase and increase extracellular adenosine generation.	WNT1 CTNNB1	6.33e-06	2	88	2	15149841
Pubmed	Absolute beta-catenin concentrations in Wnt pathway-stimulated and non-stimulated cells.	WNT1 CTNNB1	6.33e-06	2	88	2	16760136
Pubmed	Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases.	WNT1 CTNNB1	6.33e-06	2	88	2	36448560
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	6.33e-06	2	88	2	37450367
Pubmed	Low-dose radiation stimulates Wnt/β-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo.	WNT1 CTNNB1	6.33e-06	2	88	2	22272614
Pubmed	Expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma.	WNT1 CTNNB1	6.33e-06	2	88	2	19448422
Pubmed	Differential effects of oxyntomodulin and GLP-1 on glucose metabolism.	GLP1R GCGR	6.33e-06	2	88	2	22621866
Pubmed	Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria.	WNT1 CTNNB1	6.33e-06	2	88	2	19628668
Pubmed	Intervertebral disc development is regulated by Wnt/β-catenin signaling.	WNT1 CTNNB1	6.33e-06	2	88	2	21270710
Pubmed	Neuroprotective effect of fasudil on inflammation through PI3K/Akt and Wnt/β-catenin dependent pathways in a mice model of Parkinson's disease.	WNT1 CTNNB1	6.33e-06	2	88	2	26045742
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	KBTBD6 POLD1 KLHL15 KBTBD7 CRY1	1.40e-05	120	88	5	27565346
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MACC1 DCAF13 SUSD1 ZNF174 SYNE1 ZSCAN26 ASH1L ASPM MYRIP GOLGA6A PLA2G4D CDK5R2 ADCY6 PCNT	1.52e-05	1442	88	14	35575683
Pubmed	Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.	GLP1R GCGR	1.90e-05	3	88	2	22933116
Pubmed	Wnt signaling regulates hepatic metabolism.	WNT1 CTNNB1	1.90e-05	3	88	2	21285411
Pubmed	Wnt/β-catenin signaling inhibitor ICG-001 enhances pigmentation of cultured melanoma cells.	WNT1 CTNNB1	1.90e-05	3	88	2	27567978
Pubmed	[miR-218 Promoted the Apoptosis of Human Ovarian Carcinoma Cells via Suppression of the WNT/β-Catenin Signaling Pathway].	WNT1 CTNNB1	1.90e-05	3	88	2	28900081
Pubmed	Reduced E-cadherin facilitates renal cell carcinoma progression by WNT/β-catenin signaling activation.	WNT1 CTNNB1	1.90e-05	3	88	2	28223537
Pubmed	Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4.	WNT1 CTNNB1	1.90e-05	3	88	2	22392999
Pubmed	Gp91phox-derived Reactive Oxygen Species/Urocortin 2/Corticotropin-releasing Hormone Receptor Type 2 Play an Important Role in Long-term Ultraviolet A Eye Irradiation-induced Photoaging.	CYBB CRHR2	1.90e-05	3	88	2	26648475
Pubmed	Role of Wnt pathway in medulloblastoma oncogenesis.	WNT1 CTNNB1	1.90e-05	3	88	2	12209999
Pubmed	Functional analysis of mutations in TGIF associated with holoprosencephaly.	TGIF1 TGIF2	1.90e-05	3	88	2	16962354
Pubmed	Wnt/β-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer.	WNT1 CTNNB1	1.90e-05	3	88	2	24499657
Pubmed	AF1q Contributes to Adriamycin-Induced Podocyte Injury by Activating Wnt/β-Catenin Signaling.	WNT1 CTNNB1	1.90e-05	3	88	2	29069662
Pubmed	Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.	GLP1R GCGR	1.90e-05	3	88	2	15300587
Pubmed	Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.	WNT1 CTNNB1	1.90e-05	3	88	2	19693690
Pubmed	Forced overexpression of FBP1 inhibits proliferation and metastasis in cholangiocarcinoma cells via Wnt/β-catenin pathway.	WNT1 CTNNB1	1.90e-05	3	88	2	30193944
Pubmed	β Cell tone is defined by proglucagon peptides through cAMP signaling.	GLP1R GCGR	1.90e-05	3	88	2	30720465
Pubmed	A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection.	WNT1 CTNNB1	1.90e-05	3	88	2	21752258
Pubmed	Overexpression of the novel oncogene SALL4 and activation of the Wnt/beta-catenin pathway in myelodysplastic syndromes.	WNT1 CTNNB1	1.90e-05	3	88	2	19781444
Pubmed	Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.	WNT1 CTNNB1	1.90e-05	3	88	2	19924227
Pubmed	IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression.	WNT1 CTNNB1	1.90e-05	3	88	2	26450645
Pubmed	Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.	GLP1R GCGR	1.90e-05	3	88	2	30150304
Pubmed	Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.	WNT1 CTNNB1	1.90e-05	3	88	2	19061838
Pubmed	Insulin Secretion Depends on Intra-islet Glucagon Signaling.	GLP1R GCGR	1.90e-05	3	88	2	30380405
Pubmed	Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.	GLP1R GCGR	1.90e-05	3	88	2	24939431
Pubmed	Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis.	GLP1R GCGR	1.90e-05	3	88	2	21540554
Pubmed	Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling.	WNT1 CTNNB1	1.90e-05	3	88	2	16294019
Pubmed	Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in sertoli cells.	WNT1 CTNNB1	1.90e-05	3	88	2	18480464
Pubmed	Essential role of beta-catenin in postnatal bone acquisition.	WNT1 CTNNB1	1.90e-05	3	88	2	15802266
Pubmed	N-myc downstream regulated gene 1 suppresses osteoblast differentiation through inactivating Wnt/β-catenin signaling.	WNT1 CTNNB1	1.90e-05	3	88	2	35120575
Pubmed	HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer.	WNT1 CTNNB1	1.90e-05	3	88	2	19729480
Pubmed	The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.	KBTBD6 KBTBD7	1.90e-05	3	88	2	32572597
Pubmed	Wnt/β-catenin signaling and p68 conjointly regulate CHIP in colorectal carcinoma.	WNT1 CTNNB1	1.90e-05	3	88	2	34890713
Pubmed	The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.	WNT1 CTNNB1	1.90e-05	3	88	2	22139084
Pubmed	Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.	WNT1 CTNNB1	1.90e-05	3	88	2	22406377
Pubmed	Urocortin increased LPS-induced endothelial permeability by regulating the cadherin-catenin complex via corticotrophin-releasing hormone receptor 2.	CTNNB1 CRHR2	1.90e-05	3	88	2	23168683
Pubmed	Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway.	WNT1 CTNNB1	1.90e-05	3	88	2	26499380
Pubmed	Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.	GLP1R ADCY6	1.90e-05	3	88	2	22832924
Pubmed	Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.	WNT1 CTNNB1	1.90e-05	3	88	2	24480807
Pubmed	OPG is regulated by beta-catenin and mediates resistance to TRAIL-induced apoptosis in colon cancer.	WNT1 CTNNB1	1.90e-05	3	88	2	18676739
Pubmed	R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway.	WNT1 CTNNB1	1.90e-05	3	88	2	19179402
Pubmed	Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.	WNT1 CTNNB1	1.90e-05	3	88	2	7846766
Pubmed	Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting β-catenin for degradation in pancreatic cancer.	WNT1 CTNNB1	1.90e-05	3	88	2	27485116
Pubmed	Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer.	WNT1 CTNNB1	1.90e-05	3	88	2	25909283
GeneFamily	WD repeat domain containing	FBXW10B FBXW10 DCAF13 TLE2 MLST8 WDSUB1 WDR59	2.48e-05	262	60	7	362
GeneFamily	CERS class homeoboxes	CERS3 CERS4	1.61e-04	6	60	2	530
GeneFamily	Glucagon receptor family	GLP1R GCGR	1.61e-04	6	60	2	269
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	5.84e-04	11	60	2	559
GeneFamily	TALE class homeoboxes and pseudogenes	TGIF1 TGIF2	3.34e-03	26	60	2	526
Coexpression	GSE13229_IMM_VS_INTMATURE_NKCELL_DN	ABCA1 CLN3 ZSCAN26 NDST2 RIC8A CERS4 KLC1	5.10e-06	200	88	7	M3212
ToppCell	severe-Myeloid-Immature_Neutrophils_1\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CYBB KBTBD6 SYNE1 LTA4H KBTBD7 GABBR1	2.48e-06	195	88	6	becad890a420267ca41e98e61a8da343b51e1945
ToppCell	severe-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CYBB KBTBD6 SYNE1 LTA4H KBTBD7 GABBR1	2.63e-06	197	88	6	9599319dd1f80c81356a8624131566cc76d77d7e
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST2 MLST8 CDK5R2 KPNA3 TEDC1	1.80e-05	163	88	5	132aece9c79499b4bb3c2bde68d3d7202e1d8772
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB2 ABCA1 PIK3C2B SYNE1 CERS3	2.54e-05	175	88	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB SLC17A5 KLHL15 MAP6D1 SH2B2	2.68e-05	177	88	5	68f1139fc378f351e3b9e9f392aacb150025bf03
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB5 NCKAP1 ZSCAN26 POU6F1 RABGGTA	2.83e-05	179	88	5	025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTM KLHL15 GCGR DCST1 GPAT2	2.83e-05	179	88	5	d76a05f1fee7f2f7b7b7994d3622e96f02b49432
ToppCell	facs-Heart-RA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTM KLHL15 GCGR DCST1 GPAT2	2.83e-05	179	88	5	6be47c877250968a916c711ba0787eb7b4c5443d
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	KIDINS220 KLHL15 ASH1L SFI1 MAP3K4	3.40e-05	186	88	5	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MACC1 SATB2 CTTNBP2 NTM SYNE1	3.57e-05	188	88	5	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYBB KBTBD6 SYNE1 LTA4H GABBR1	3.66e-05	189	88	5	3b35022c0619df6db234613aa53a076899ca9562
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYBB KBTBD6 SYNE1 LTA4H GABBR1	3.66e-05	189	88	5	358ff514f1c8aa46067208ddf1b68396d789c130
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYBB KBTBD6 SYNE1 LTA4H KBTBD7	3.76e-05	190	88	5	896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCell	control-Myeloid-Immature_Neutrophils_1\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CYBB KBTBD6 SYNE1 LTA4H KBTBD7	3.76e-05	190	88	5	38e83337c70c8734b63f8589ba59e0f98603f94c
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CYBB KBTBD6 SYNE1 LTA4H GABBR1	3.85e-05	191	88	5	6c1283d51a845cff67ed5e500f7e944165297b53
ToppCell	3'_v3-Lung-Mast\|Lung / Manually curated celltypes from each tissue	CTTNBP2 NTM NDST2 MYRIP WNK3	4.15e-05	194	88	5	5e6eb81ddc9d5e22c1297734689f476d5a05bff6
ToppCell	3'_v3-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	CTTNBP2 NTM NDST2 MYRIP WNK3	4.15e-05	194	88	5	7b7f1714c4a9d9519c4d0e460cb87f2eb82392dd
ToppCell	COVID-19_Severe-Neu_2\|World / 5 Neutrophil clusters in COVID-19 patients	CYBB KBTBD6 SYNE1 LTA4H GABBR1	4.36e-05	196	88	5	16359a56297f0558fc93fa52563cce0c53def167
ToppCell	COVID-19_Severe-Neu_2\|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients	CYBB KBTBD6 SYNE1 LTA4H GABBR1	4.46e-05	197	88	5	945f19475905cdedf232315eea1076ca0b753b67
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	SATB2 CTTNBP2 KIDINS220 NTM KLC1	4.68e-05	199	88	5	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	COVID-19-COVID-19_Severe-Myeloid-immature_Neutrophil\|COVID-19_Severe / Disease, condition lineage and cell class	CYBB KBTBD6 SYNE1 LTA4H GABBR1	4.79e-05	200	88	5	cbe667eda1af222467df8bfa157aa22df488f133
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	SATB2 CTTNBP2 KIDINS220 NTM KLC1	4.79e-05	200	88	5	c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	CTTNBP2 KIDINS220 NCKAP1 NTM SYNE1	4.79e-05	200	88	5	44bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal\|3m / Sample Type, Dataset, Time_group, and Cell type.	SATB2 CTTNBP2 KIDINS220 NTM KLC1	4.79e-05	200	88	5	af99d90070e2933fd2e9512590c6cf3bd6e15539
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW13-Neuronal\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	SATB2 KIDINS220 NTM	6.78e-05	40	88	3	a55d9861170f41049748cd093d3d680855553d1d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW13-Neuronal-Neurons\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	SATB2 KIDINS220 NTM	6.78e-05	40	88	3	7d7dc8dd5b095b7e3a83cbf840c4ee4f650bbc7c
Drug	rishitin	CYBB ABCA1 LTA4H	1.80e-06	7	86	3	CID000108064
Disease	congenital dyserythropoietic anemia type II (implicated_via_orthology)	SEC23B SEC23A	7.44e-06	2	81	2	DOID:0111401 (implicated_via_orthology)
Disease	craniolenticulosutural dysplasia (implicated_via_orthology)	SEC23B SEC23A	7.44e-06	2	81	2	DOID:0070307 (implicated_via_orthology)
Disease	arthrogryposis multiplex congenita (is_implicated_in)	VPS33B SYNE1	4.45e-05	4	81	2	DOID:0080954 (is_implicated_in)
Disease	Roberts syndrome (implicated_via_orthology)	SEC23B SEC23A	4.45e-05	4	81	2	DOID:5325 (implicated_via_orthology)
Disease	Multiple congenital anomalies	POLD1 CTNNB1	9.85e-04	17	81	2	C0000772
Disease	Colorectal Neoplasms	SATB2 ABCA1 POLD1 SYNE1 CTNNB1	1.01e-03	277	81	5	C0009404
Disease	Endometrial Carcinoma	POLD1 CTNNB1 MAP3K4	1.04e-03	72	81	3	C0476089
Disease	leukemia (implicated_via_orthology)	HOXD4 ASH1L	1.23e-03	19	81	2	DOID:1240 (implicated_via_orthology)
Disease	Primary microcephaly	ASPM CTNNB1	1.66e-03	22	81	2	C0431350
Disease	Hepatitis	TGIF1 NTM	1.66e-03	22	81	2	HP_0012115
Disease	Hypertensive disease	CYBB GLP1R F12 CRHR2	1.88e-03	190	81	4	C0020538
Disease	Neurodevelopmental Disorders	NCKAP1 ASH1L CTNNB1	2.16e-03	93	81	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
QDQRCRDRVQDLSWL	AMER3	741	Q8N944
QILVNIKSCRWRHFR	EPC1	516	Q9H2F5
CRAVLGLWRQRLLQS	C1orf167	936	Q5SNV9
QRIQRHEWVQCLERF	ASH1L	2136	Q9NR48
QCGLTLQQTQRWFRR	CERS4	106	Q9HA82
VFSQLFCLERLWLQR	CPN2	236	P22792
RSCWRRLVQVFQSKQ	ADCY6	116	O43306
TKEWFCRINDISQRR	FBXW10	41	Q5XX13
LWKNLTFRRRQTCQL	ABCA1	11	O95477
EQQELRACLRWRRLQ	AOPEP	526	Q8N6M6
ERFWQRCLRLIQRLS	CDK5R2	291	Q13319
VRIWNLTQRNCIRTI	DCAF13	91	Q9NV06
VNSVICIQRWFRARL	ASPM	3141	Q8IZT6
CIQRWFRARLQEKRF	ASPM	3146	Q8IZT6
KSQNWDCNVRHILRR	RAD51AP2	391	Q09MP3
HILRRNRGNCWIINN	RAD51AP2	401	Q09MP3
QCRCRLQEVLAQLRW	RIMBP3B	161	A6NNM3
CTQWLNVRDLDRLQR	RIMBP3B	516	A6NNM3
QCRCRLQEVLAQLRW	RIMBP3C	161	A6NJZ7
CTQWLNVRDLDRLQR	RIMBP3C	516	A6NJZ7
SCREAVLQRWLQQTI	GOLGA6A	191	Q9NYA3
NNSEIRFRWLRLCIQ	LTA4H	531	P09960
TKEWFCRINDISQRR	FBXW10B	41	O95170
RLVQNCLWTLRNLSD	CTNNB1	376	P35222
FLRNVTWVIVNLCRN	KPNA3	216	O00505
RLLRANQISFNWDRL	KIDINS220	951	Q9ULH0
FRNQEIQRALWLLLC	GPR6	331	P46095
RCTIDNRVTRVAWLN	NTM	56	Q9P121
VQKWREYRRQCQRSL	GLP1R	36	P43220
RNQFPFVCQARLWLL	GABBR1	656	Q9UBS5
RRNPAANLIQCVWRS	KCNQ5	366	Q9NR82
DCTARIWDLRSRNLQ	MLST8	106	Q9BVC4
IWDLRSRNLQCQRIF	MLST8	111	Q9BVC4
CFLNKEVQSELRRRW	GCGR	401	P47871
LRSIRCLRNVIHWNL	CRHR2	141	Q13324
EVVRVWFCNRRQTLK	POU6F1	276	Q14863
AQNSWQQLADRLLCR	KBTBD7	411	Q8WVZ9
NALWLNERECSIQRR	PCCA	281	P05165
WLRAQCARLSRQLQV	PCNT	1921	O95613
RRNLSADQWRNAQLL	NCKAP1	216	Q9Y2A7
RDVITQCIQRLQLWL	OR2AE1	306	Q8NHA4
LREEFNRQCWLVNAL	PIK3C2B	986	O00750
LCLSERQIKIWFQNR	HOXB5	231	P09067
LCLSERQIKIWFQNR	HOXD4	191	P09016
DNTNLRCWRVNNTLV	IL1RL2	256	Q9HB29
CNLTERQVERWFRSR	CERS3	106	Q8IU89
RWRHTDTIIQNIRFC	KLHL15	211	Q96M94
ALSVWRQLNSCLARL	CTTNBP2	1311	Q8WZ74
VVNQAILSCRRWFDR	DCST1	251	Q5T197
NVGINRWRFLLQCLE	CRY1	46	Q16526
RWRFLLQCLEDLDAN	CRY1	51	Q16526
WALLRFLNCLFLNVQ	GPAT2	166	Q6NUI2
QTCWASRRREQLLRE	ATRNL1	1256	Q5VV63
AWLSQRQLARSCLDL	MACC1	181	Q6ZN28
ISRLCCLARRWNQLD	MAP6D1	6	Q9H9H5
LCERLVRFWRSQQKV	CYBB	281	P04839
ITFWCSLQRSRRQLH	DGKE	36	P52429
HQCRRFRQPQWQLLD	SLC22A12	86	Q96S37
NLRAKWNFSTLCVRR	SLC17A5	351	Q9NRA2
ALEERFSRLWTQCQR	POLD1	1046	P28340
AQNSWQQLADRLLCR	KBTBD6	411	Q86V97
RRLCQENQWLRDELA	KLC1	111	Q07866
KTRRQWRRSQFCDIN	PANX2	331	Q96RD6
CWQLTVRVLEARNLR	PLA2G4D	21	Q86XP0
FQDRVQALCLWLNIT	MAP3K4	386	Q9Y6R4
NDIRPWCFVLNRDRL	F12	271	P00748
QKVLDRGCLRTWFQR	SFI1	746	A8K8P3
AQRLSRTCFRQWRQQ	SFI1	816	A8K8P3
LACLAKRTVNRQWSR	TDRD6	821	O60522
QATRNLDRRWRNICA	SYNE1	7971	Q8NF91
QCRCRLQEVLAQLRW	RIMBP3	161	Q9UFD9
CTQWLNVRDLDRLQR	RIMBP3	516	Q9UFD9
DFATLWNCRREVLQQ	RABGGTA	61	Q92696
NRTLWENLCTIRRFL	SATB2	531	Q9UPW6
WLQSVRILSRDRNCL	RIC8A	66	Q9NPQ8
DVLRWLDRQLIRLCQ	SEC23A	541	Q15436
RWLDRQLIRLCQKFG	SEC23B	546	Q15437
SVLQICNWFINARRR	TGIF2	61	Q9GZN2
RIRFTWALALLQCLN	CLN3	341	Q13286
LSTLQVCNWFINARR	TGIF1	206	Q15583
VCNWFINARRRLLPD	TGIF1	211	Q15583
DCSLALVWRNNERLQ	USP19	1016	O94966
QEALSQLRQLCRQWL	ZNF174	61	Q15697
LFNDTCVRWQINSRR	SUSD1	306	Q6UWL2
RFRWRQLVSSQQEQC	TEDC1	176	Q86SX3
VRFLQCWTRLRLQTL	NDST2	546	P52849
AQWQKCRLLLRRAVA	SH2B2	216	O14492
QLRRENSLLLWNVFD	WDR59	256	Q6PJI9
REALSRLRELCQQWL	ZSCAN26	66	Q16670
RRELCTQLRQWQLKV	ZSWIM8	441	A7E2V4
LQSAVRECKWQFRNR	WNT1	86	P04628
NIWQFDLETLCQARR	WDSUB1	306	Q8N9V3
NTVRCWDLREGRQLQ	TLE2	611	Q04725
SCRIIEQVLERRSWQ	VPS33B	521	Q9H267
QWTIQNRRLCGLRIL	TMPRSS6	401	Q8IU80
WRFCINQTIRNRETQ	WNK3	871	Q9BYP7
VCQQARLLRAQSLEW	MYRIP	106	Q8NFW9