Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhemoglobin beta binding

HBB HBD

6.91e-062532GO:0031722
GeneOntologyMolecularFunctionhemoglobin alpha binding

HBB HBD

6.88e-055532GO:0031721
GeneOntologyMolecularFunctionhaptoglobin binding

HBB HBD

3.07e-0410532GO:0031720
GeneOntologyMolecularFunctionhemoglobin binding

HBB HBD

3.74e-0411532GO:0030492
GeneOntologyMolecularFunctionoxygen carrier activity

HBB HBD

6.16e-0414532GO:0005344
GeneOntologyMolecularFunctionadenylate cyclase binding

AKAP6 AKAP12

8.10e-0416532GO:0008179
GeneOntologyCellularComponenthaptoglobin-hemoglobin complex

HBB HBD

4.10e-0412532GO:0031838
GeneOntologyCellularComponenthemoglobin complex

HBB HBD

4.10e-0412532GO:0005833
GeneOntologyCellularComponentbeta-catenin destruction complex

APC AXIN1

4.83e-0413532GO:0030877
GeneOntologyCellularComponentWnt signalosome

APC AXIN1

7.40e-0416532GO:1990909
DomainHaemoglobin_b

HBB HBD

7.86e-055532IPR002337
DomainGlobin

HBB HBD

5.12e-0412532IPR000971
DomainGlobin

HBB HBD

5.12e-0412532PF00042
DomainGLOBIN

HBB HBD

5.12e-0412532PS01033
Domain-

HBB HBD

6.04e-04135321.10.490.10
DomainGlobin/Proto

HBB HBD

6.04e-0413532IPR012292
DomainGlobin-like

HBB HBD

9.24e-0416532IPR009050
DomainMYB_LIKE

GON4L MIER1

5.20e-0338532PS50090
DomainLAM_G_DOMAIN

NRXN2 COL27A1

5.20e-0338532PS50025
DomainSANT

GON4L MIER1

8.87e-0350532SM00717
DomainSANT/Myb

GON4L MIER1

9.57e-0352532IPR001005
PathwayREACTOME_ERYTHROCYTES_TAKE_UP_OXYGEN_AND_RELEASE_CARBON_DIOXIDE

HBB HBD

1.78e-049322MM14530
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_AXIN_TO_WNT_SIGNALING_PATHWAY

APC AXIN1

2.22e-0410322M47486
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_APC_TO_WNT_SIGNALING_PATHWAY

APC AXIN1

3.25e-0412322M47410
PathwayREACTOME_HEME_SIGNALING

HBB HBD

3.83e-0413322MM15685
PathwayREACTOME_ERYTHROCYTES_TAKE_UP_CARBON_DIOXIDE_AND_RELEASE_OXYGEN

HBB HBD

3.83e-0413322MM14529
PathwayBIOCARTA_PS1_PATHWAY

APC AXIN1

4.47e-0414322MM1459
PathwayBIOCARTA_PS1_PATHWAY

APC AXIN1

4.47e-0414322M16173
PathwayBIOCARTA_PITX2_PATHWAY

APC AXIN1

5.15e-0415322MM1439
PathwayREACTOME_SIGNALING_BY_CTNNB1_PHOSPHO_SITE_MUTANTS

APC AXIN1

5.15e-0415322M27407
PathwayBIOCARTA_PITX2_PATHWAY

APC AXIN1

5.87e-0416322M8516
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

APC AXIN1

6.65e-0417322M27083
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

APC AXIN1

6.65e-0417322M39525
PathwayBIOCARTA_TGFB_PATHWAY

APC SKIL

6.65e-0417322MM1509
PathwayPID_BETA_CATENIN_DEG_PATHWAY

APC AXIN1

7.47e-0418322M31
PathwayREACTOME_BETA_CATENIN_PHOSPHORYLATION_CASCADE

APC AXIN1

7.47e-0418322MM14759
PathwayBIOCARTA_TGFB_PATHWAY

APC SKIL

8.33e-0419322M18933
PathwayPID_WNT_CANONICAL_PATHWAY

APC AXIN1

9.25e-0420322M90
PathwayBIOCARTA_GSK3_PATHWAY

APC AXIN1

9.25e-0420322M11106
PathwayBIOCARTA_GSK3_PATHWAY

APC AXIN1

1.12e-0322322MM1421
PathwayBIOCARTA_WNT_PATHWAY

APC AXIN1

1.23e-0323322MM1527
PathwayBIOCARTA_WNT_PATHWAY

APC AXIN1

1.34e-0324322M16517
PathwayWP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS

APC AXIN1

1.95e-0329322M39516
PathwayPID_NECTIN_PATHWAY

AFDN PIP5K1C

2.09e-0330322M72
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

APC AXIN1

2.23e-0331322M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

APC AXIN1

2.23e-0331322MM15154
PathwayPID_NCADHERIN_PATHWAY

PIP5K1C AXIN1

2.52e-0333322M266
PathwayREACTOME_SIGNALING_BY_WNT_IN_CANCER

APC AXIN1

2.68e-0334322M27405
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

APC AXIN1

3.16e-0337322M47411
PathwayBIOCARTA_ALK_PATHWAY

APC AXIN1

3.16e-0337322M17400
PathwayWP_INFLUENCE_OF_LAMINOPATHIES_ON_WNT_SIGNALING

APC AXIN1

3.16e-0337322M39817
PathwayPID_ECADHERIN_NASCENT_AJ_PATHWAY

AFDN PIP5K1C

3.51e-0339322M156
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

AFDN ADAM33

3.69e-0340322MM15060
PathwayPID_ECADHERIN_STABILIZATION_PATHWAY

AFDN PIP5K1C

3.87e-0341322M232
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

APC AXIN1

4.45e-0344322MM15878
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL27A1 COL25A1

4.45e-0344322M27812
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

APC AXIN1

4.65e-0345322M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

APC AXIN1

4.85e-0346322M47409
PathwayPID_PS1_PATHWAY

APC AXIN1

4.85e-0346322M70
Pubmed

A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA.

HBB HBD

2.28e-0625326086313
Pubmed

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.

HBB HBD

2.28e-06253222203977
Pubmed

A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia.

HBB HBD

2.28e-06253216631345
Pubmed

Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia.

HBB HBD

2.28e-06253237902616
Pubmed

Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences.

HBB HBD

2.28e-062532270684
Pubmed

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.

HBB HBD

2.28e-06253221099112
Pubmed

A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus.

HBB HBD

2.28e-06253211121056
Pubmed

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer.

HBB HBD

2.28e-06253212480689
Pubmed

Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence.

HBB HBD

2.28e-062532482942
Pubmed

Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity.

HBB HBD

2.28e-06253211830454
Pubmed

Second generation knockout sickle mice: the effect of HbF.

HBB HBD

2.28e-06253211154217
Pubmed

Decreased hepcidin mRNA expression in thalassemic mice.

HBB HBD

2.28e-06253214675418
Pubmed

Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1).

HBB HBD

2.28e-06253210441738
Pubmed

Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche.

HBB HBD

2.28e-06253232344432
Pubmed

Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D3.

HBB HBD

2.28e-06253231562377
Pubmed

Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level.

APC AXIN1

2.28e-06253232005247
Pubmed

The complete nucleotide sequence of a beta-globin-like structure, beta h2, from the [Hbb]d mouse BALB/c.

HBB HBD

2.28e-0625326736028
Pubmed

Running exercise alleviates trabecular bone loss and osteopenia in hemizygous β-globin knockout thalassemic mice.

HBB HBD

2.28e-06253224780610
Pubmed

Effects of human gamma-globin in murine beta-thalassaemia.

HBB HBD

2.28e-06253216803575
Pubmed

First report on the co-inheritance of beta-globin IVS-I-5 (G-->C) thalassemia with delta globin CD12 {Asn-->Lys (AAT-->AAA)}HbA₂-NYU in Iran.

HBB HBD

2.28e-06253221194254
Pubmed

The adult beta-globin genes of the "single" type mouse C57BL.

HBB HBD

2.28e-0625327237554
Pubmed

Significance of borderline hemoglobin A2 values in an Italian population with a high prevalence of beta-thalassemia.

HBB HBD

2.28e-06253218603555
Pubmed

Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns.

HBB HBD

2.28e-062532264241
Pubmed

Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes.

HBB HBD

2.28e-06253211418464
Pubmed

Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.

HBB HBD

2.28e-06253227245334
Pubmed

Co-inheritance of alpha- and beta-thalassaemia in mice ameliorates thalassaemic phenotype.

HBB HBD

2.28e-06253217493845
Pubmed

An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression.

HBB HBD

2.28e-06253228641125
Pubmed

A mouse model for beta 0-thalassemia.

HBB HBD

2.28e-0625328524813
Pubmed

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.

HBB HBD

2.28e-06253221304105
Pubmed

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

HBB HBD

2.28e-06253225616571
Pubmed

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.

HBB HBD

2.28e-06253230422819
Pubmed

β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications.

HBB HBD

2.28e-06253224297746
Pubmed

Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro.

HBB HBD

2.28e-062532338418
Pubmed

Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice.

HBB HBD

2.28e-06253232385316
Pubmed

The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.

HBB HBD

2.28e-062532519759
Pubmed

Genetic alterations in members of the Wnt pathway in acute leukemia.

APC AXIN1

2.28e-06253221902576
Pubmed

Neutralizing the function of a β-globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain.

HBB HBD

2.28e-06253223074246
Pubmed

Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation.

HBB HBD

2.28e-06253216421096
Pubmed

High phosphate intake induces bone loss in nephrectomized thalassemic mice.

HBB HBD

2.28e-06253235622784
Pubmed

A humanized mouse model for a common beta0-thalassemia mutation.

HBB HBD

2.28e-06253215780748
Pubmed

Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.

HBB HBD

2.28e-0625327935410
Pubmed

Evolution of the mouse beta-globin genes: a recent gene conversion in the Hbbs haplotype.

HBB HBD

2.28e-0625323870864
Pubmed

Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene.

HBB HBD

2.28e-06253211877258
Pubmed

Molecular characterization of (deltabeta)(0)/beta(0)-thalassemia and (deltabeta)(0)-thalassemia/hemoglobin E in Thai patients.

HBB HBD

2.28e-06253211860449
Pubmed

Tracking of mouse cell lineage using microinjected DNA sequences: analyses using genomic Southern blotting and tissue-section in situ hybridizations.

HBB HBD

2.28e-0625323428512
Pubmed

Structural basis of the Axin-adenomatous polyposis coli interaction.

APC AXIN1

2.28e-06253210811618
Pubmed

The molecular characterization of an A:T to G:C transition in the Hbb-b1 gene of the murine homologue of hemoglobin Rainier.

HBB HBD

2.28e-0625321820025
Pubmed

Super-resolution imaging reveals three-dimensional folding dynamics of the β-globin locus upon gene activation.

HBB HBD

2.28e-06253222767512
Pubmed

Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment.

HBB HBD

2.28e-06253215820143
Pubmed

The beta-delta crossover leading to the beta delta hybrid gene of hemoglobin P-Nilotic is located within 54 base-pairs of the 5' end of exon 2 or between codons 31 and 50.

HBB HBD

2.28e-0625323620470
Pubmed

Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb.

HBB HBD

2.28e-06253212127975
Pubmed

The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites.

HBB HBD

2.28e-062532569555
Pubmed

The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer.

HBB HBD

2.28e-06253224817273
Pubmed

Ligation-mediated amplification of RNA from murine erythroid cells reveals a novel class of beta globin mRNA with an extended 5'-untranslated region.

HBB HBD

2.28e-0625328041612
Pubmed

A 66-base pair insert bridges the deletion responsible for a mouse model of beta-thalassemia.

HBB HBD

2.28e-0625323017971
Pubmed

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.

HBB HBD

2.28e-06253233822774
Pubmed

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.

HBB HBD

2.28e-06253227959920
Pubmed

Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

HBB HBD

2.28e-062532273235
Pubmed

Mouse haemoglobin beta chains. Comparative sequence data on adult major and minor beta chains from two species, Mus musculus and Mus cervicolor.

HBB HBD

2.28e-062532999642
Pubmed

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.

HBB HBD

2.28e-06253222427201
Pubmed

Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice.

HBB HBD

2.28e-06253235396390
Pubmed

Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition.

HBB HBD

2.28e-06253232745462
Pubmed

Molecular characterization of a novel homozygous deletion in β-globin cluster causing (δβ)0-Thalassemia among Tunisian family.

HBB HBD

2.28e-06253236214153
Pubmed

The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

HBB HBD

2.28e-062532728996
Pubmed

Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells.

HBB HBD

2.28e-06253214615383
Pubmed

CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia.

HBB HBD

2.28e-06253223157711
Pubmed

HbA2-Partinico or delta(A2)Pro-->Thr, a new genetic variation in the delta-globin gene in cis to the beta(+) thal IVS-I-110 G>A, and the heterogeneity of delta-globin alleles in double heterozygotes for beta- and delta-globin gene defects.

HBB HBD

2.28e-06253219609526
Pubmed

Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus.

HBB HBD

2.28e-06253218299925
Pubmed

Hemoglobin induction in mouse macrophages.

HBB HBD

2.28e-06253210359765
Pubmed

Evolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in Mus.

HBB HBD

2.28e-06253219675095
Pubmed

Transposition of a long member of the L1 major interspersed DNA family into the mouse beta globin gene locus.

HBB HBD

2.28e-0625322991851
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TAF6L TCF20 SMCHD1 ZBTB21 SKIL PRRC2B

3.35e-0626853633640491
Pubmed

A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression.

HBB HBD

6.83e-06353221281810
Pubmed

CTNNB1, AXIN1 and APC expression analysis of different medulloblastoma variants.

APC AXIN1

6.83e-06353223525311
Pubmed

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.

HBB HBD

6.83e-06353217607360
Pubmed

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

HBB HBD

6.83e-06353228151426
Pubmed

Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity.

HBB HBD

6.83e-06353212458204
Pubmed

In vivo blood flow abnormalities in the transgenic knockout sickle cell mouse.

HBB HBD

6.83e-06353210079113
Pubmed

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling.

HBB HBD

6.83e-06353222461476
Pubmed

Secondary structure of mouse and rabbit alpha- and beta-globin mRNAs: differential accessibility of alpha and beta initiator AUG codons towards nucleases.

HBB HBD

6.83e-0635327357610
Pubmed

Inhibition of FGF23 is a therapeutic strategy to target hematopoietic stem cell niche defects in β-thalassemia.

HBB HBD

6.83e-06353237256933
Pubmed

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction.

HBB HBD

6.83e-06353219734452
Pubmed

Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.

HBB HBD

6.83e-06353222287545
Pubmed

Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer.

APC AXIN1

6.83e-06353231723073
Pubmed

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.

HBB HBD

6.83e-06353232107334
Pubmed

Characterization and kinetics of synthesis of 15S beta-globin RNA, a putative precursor of beta-globin mRNA.

HBB HBD

6.83e-063532277329
Pubmed

Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins.

HBB HBD

6.83e-0635329787139
Pubmed

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.

HBB HBD

6.83e-06353226276665
Pubmed

Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons.

HBB HBD

6.83e-06353223685348
Pubmed

AXIN1 Expression and Localization in Meningiomas and Association to Changes of APC and E-cadherin.

APC AXIN1

6.83e-06353227630299
Pubmed

Antisickling effects of an endogenous human alpha-like globin.

HBB HBD

6.83e-06353215034572
Pubmed

A mechanism for Ikaros regulation of human globin gene switching.

HBB HBD

6.83e-06353218318763
Pubmed

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.

HBB HBD

6.83e-06353223975182
Pubmed

Complex signatures of selection and gene conversion in the duplicated globin genes of house mice.

HBB HBD

6.83e-06353217660536
Pubmed

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry.

HBB HBD

6.83e-06353234002695
Pubmed

Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.

APC AXIN1

6.83e-06353215981102
Pubmed

Crystal structure of hemoglobin from mouse (Mus musculus) compared with those from other small animals and humans.

HBB HBD

6.83e-06353233830076
Pubmed

different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.

APC AXIN1

6.83e-06353224722208
Pubmed

Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes.

HBB HBD

6.83e-06353216716198
Pubmed

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.

HBB HBD

6.83e-06353233941818
InteractionCLEC11A interactions

TCF20 ZBTB21 ZNF805 USP54 PRRC2B

5.29e-0696535int:CLEC11A
GeneFamilyHemoglobin subunits

HBB HBD

2.23e-0410412940
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R26 PHACTR4 APC AXIN1

7.37e-04181414694
GeneFamilyZinc fingers MYND-type|A-kinase anchoring proteins

AKAP6 AKAP12

1.96e-0329412396
GeneFamilyCollagens

COL27A1 COL25A1

4.88e-0346412490
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF536 ZNF837 ZBTB21 ZNF805 ZNF75D ZNF646

5.27e-0371841628
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

GON4L MIER1

6.43e-0353412532
CoexpressionGSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_72H_CD4_TCELL_UP

CDK12 AHNAK ZNF805 CASP4 GNPTG SKIL

2.69e-06195536M4201
ToppCellnormal-na-Lymphocytic_T-T4_em-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SMCHD1 AHNAK AFDN HBB AKAP12

2.03e-0617154561318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMCHD1 AHNAK APC MIER1 AKAP12

2.91e-061845451154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FILIP1 CDK12 TEF MIER1 AKAP12

3.77e-06194545e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KLHL29 FILIP1 ZNF536 ADAM33 AKAP12

4.06e-061975450dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 ZNF536 IGFBP2 NRXN2 COL25A1

4.17e-0619854552ddc1f1ed4ac4c3bac794c90b8feb03e3c221c4
ToppCellHealthy-CD4+_T_activated|World / disease group, cell group and cell class

SUOX CDK12 COL27A1 CALY

2.52e-05140544407691970ec72a3afb45e431cf48814546b8acff
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-tDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAM33 TEF SLC4A3 KLB

2.89e-05145544a6c291811bf62f1c13f1b4b396d75c2223cf1c7d
ToppCellHealthy-CD4+_T_activated|Healthy / disease group, cell group and cell class

SUOX CDK12 COL27A1 CALY

2.89e-0514554445e8089fdf7d6f69b383816d8945e39fba24c873
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NRXN2 HBD HBB SLC4A3

2.97e-0514654403a6a442f1f6d173a41aeebbfe41ee08853d9585
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

AKAP6 PPP1R26 USP54 TEF

6.28e-05177544e8ab340b20cd41554c3841fe980e078e878af35f
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FILIP1 CDK12 SMCHD1 MIER1

6.42e-0517854401dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellRA-16._Neuronal|RA / Chamber and Cluster_Paper

KLHL29 ZNF536 AHNAK PHACTR4

6.70e-051805445842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 IGFBP2 NRXN2 COL25A1

6.85e-05181544098dbb3e0ff531c9720a233123250c1e39a97d4c
ToppCellRA-16._Neuronal|World / Chamber and Cluster_Paper

KLHL29 ZNF536 AHNAK PHACTR4

6.85e-051815447d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IGFBP2 COL27A1 ADAM33 COL25A1

6.85e-051815446d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMCHD1 AHNAK MIER1 AKAP12

7.00e-05182544f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

CDK12 SMCHD1 PHACTR4 SKIL

7.15e-051835448f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 FILIP1 CALY COL25A1

7.15e-051835448de4b616a06be03e1cb6ae6a9ce6bf06485629d3
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FILIP1 NRXN2 ADAM33 AKAP12

7.30e-05184544590fb32bb1f348ea5fa2aece30ebe1e212512991
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 CALY ADAM33 COL25A1

7.45e-0518554416e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMCHD1 AHNAK MIER1 AKAP12

7.45e-051855447adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 FILIP1 ADAM33 COL25A1

8.10e-051895442cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 NRXN2 ADAM33 AKAP12

8.10e-0518954429287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 NRXN2 ADAM33 AKAP12

8.10e-051895447150dad9a92a715487c2d8130fa01b752ea69663
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF536 NRXN2 ADAM33 AKAP12

8.10e-051895446e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 FILIP1 ADAM33 COL25A1

8.10e-05189544127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 FILIP1 ZNF536 ADAM33

8.26e-05190544f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCellwk_08-11-Epithelial-PNS-Schwann_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ZNF536 IGFBP2 NRXN2 COL25A1

8.26e-051905444a777d8aa19cadd3b61b023772df142421a89113
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

KLHL29 NRXN2 ADAM33 AKAP12

8.26e-051905444f775ee24b14733f06ae40b45f2dc1a0f0df0705
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AKAP6 FILIP1 ZNF536 ADAM33

8.26e-05190544562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellsevere_COVID-19|World / disease group, cell group and cell class (v2)

IGFBP2 DAP HBD HBB

8.78e-051935449012cadd138be775fb167a5bc895e512619f8a95
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 DAP AFDN USP54

8.78e-05193544eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

AKAP6 FILIP1 IGFBP2 EFHB

8.78e-05193544ea345d34440b25f65358a53dc72831998d1c3620
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

KLHL29 NRXN2 ADAM33 AKAP12

8.78e-05193544adc9fc94f9ec686a417d08c0b8b7b7ab687afec0
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHL29 DAP AFDN USP54

8.95e-051945445d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 IGFBP2 NRXN2 COL25A1

9.13e-051955449fea1ddb68da83ca43dd8006c9e51295b1817f0e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 COL27A1 COL25A1 AKAP12

9.13e-0519554444d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 IGFBP2 NRXN2 COL25A1

9.32e-051965449afd0a7135028a446f06bb68f334e79b8f171b45
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KLHL29 ZNF536 ADAM33 AKAP12

9.50e-05197544ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCellCOVID-19_Severe-PLT_5|World / Disease Group and Platelet Clusters

IGFBP2 DAP HBD HBB

9.88e-05199544937e4028f896bc6b751182517611825d6716c682
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

ZNF536 NRXN2 AFDN SLC4A3

1.01e-04200544bad32a95b759fad509401b07bc96a56687c2a592
ToppCellCOVID-19|World / Disease, condition lineage and cell class

SMCHD1 AHNAK HBB MIER1

1.01e-042005447dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons|GW23 / Sample Type, Dataset, Time_group, and Cell type.

ZNF536 NRXN2 AFDN SLC4A3

1.01e-04200544c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-hematologic-erythrocytic-erythroid_lineage_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

OR10H2 HBD HBB

3.76e-04116543a080b3bba1f5ae714faef121ace1011c864eca8a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZNF536 IGFBP2 COL25A1

4.16e-04120543a4e3f9a83bc52ccc75bcd64b1be4e2c5441f6d1a
ToppCellMild-Myeloid-Macrophages-|Mild / Condition, Lineage, Cell class and cell subclass

KLHL29 ZNF536 HBD

4.36e-04122543b837456a6a236add2c0005cb3ca71568d631014e
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

HBD HBB AKAP12

5.61e-04133543386c9bbd9bab62209a67ebae6cd6ac0d7cef0a2d
ToppCellE16.5-samps-Mesenchymal-Myofibroblast-Smooth_Muscle-like_MyoFibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

AKAP6 KLHL29 ADAM33

6.51e-041405435623a0a68403fc00166b7d13d13e184a718d9bdd
ToppCellTracheal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

USP54 TEF MIER1

6.51e-041405430e1e9281de87df178ac41ed6b697b4fa09be2749
ToppCellcritical-Lymphoid-NKT|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

IGFBP2 EFHB HBB

6.93e-04143543dca035bfbfd1665c04076c43da8bc18a1502b9de
ToppCell10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT|GI_small-bowel / Manually curated celltypes from each tissue

NRXN2 AHNAK AFDN

7.35e-041465431cb2e157222631e8915d89b255a843d16d7d99cc
ToppCellfacs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNMA5 NRXN2 AHNAK

7.50e-041475439d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCellfacs-Marrow-B-cells-24m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNMA5 NRXN2 AHNAK

7.50e-0414754338552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCellRV-16._Neuronal|World / Chamber and Cluster_Paper

ZNF536 AHNAK CALY

7.80e-041495433a2f8c4173dcf9e3f8d3b8ffddbc597098adf7a9
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3|E16.5-samps / Age Group, Lineage, Cell class and subclass

PPP1R26 ZSWIM8 COL25A1

7.80e-04149543651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCellHealthy_donor-B_cell|World / disease group, cell group and cell class (v2)

AKAP6 CALY SLC4A3

7.95e-04150543a2dfed562de7f58f902b547acec5a13853c80c4c
ToppCellmild-Myeloid-Neutrophils_4|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SMCHD1 HBD HBB

7.95e-04150543979566663d1110475f1e017c2f9890aca4b6f701
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF837 HBD HBB

7.95e-041505436bdf9df586f348641a25a445e83a41e47e7f347e
ToppCellSevere_COVID-19-undefined|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

KLHL29 ZNF837 AKAP12

8.11e-041515432ae403417fcb3fe402f6f47bb60ffa68d5fefd2a
ToppCellSevere_COVID-19-undefined-undefined|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

KLHL29 ZNF837 AKAP12

8.11e-04151543b402185dd7a93c6d0ec5c4d84d5031a157ee8cfb
ToppCellHealthy_donor-B_cell|Healthy_donor / disease group, cell group and cell class (v2)

AKAP6 CALY SLC4A3

8.26e-041525435768edfde8010324d8594815e73bbfba2c3045f3
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ZNF536 IGFBP2 COL25A1

8.26e-041525438ff5a178a8f3550d89a003c0858820aab3773386
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KLHL29 IGFBP2 HBD

8.58e-041545436c1e7682c43c40b58b371c58deb10b839700ebcc
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|367C / Donor, Lineage, Cell class and subclass (all cells)

KLHL29 IGFBP2 HBD

8.91e-041565431a0e081284a99c1b345990775015b8a2fa469496
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

APC ZNF75D ADAM33

8.91e-04156543f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCellCD8+_Memory_T_cell-RSV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

PPP1R26 IGFBP2 TCF20

9.24e-041585435ae737757a49fc96bde1e57e02066f9f65654ea1
ToppCellSevere-Lymphoid-NK-Proliferating_T|Severe / Condition, Lineage, Cell class and cell subclass

ZNF837 USP54 TEF

9.58e-04160543cb2276d9bd78508644420e9580d3c17b914224cb
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

AHNAK ZNF837 AFDN

9.58e-04160543529034a1101d7772d82f86beb5c6fa9c9dd97067
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

AKAP6 ZNF536 ADAM33

9.58e-04160543d783d29150033e9181c0e30870070268fed3fd85
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 COL25A1 AKAP12

9.93e-041625435f009b231f21861afee9cc0c569082e1135f929c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 COL25A1 AKAP12

9.93e-04162543b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCell343B-Fibroblasts-Fibroblast-D-|343B / Donor, Lineage, Cell class and subclass (all cells)

NRXN2 ADAM33 AKAP12

1.01e-031635438d2b2119c6b3d5b677da6f377fd85146590e1246
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PNMA5 ZNF837 CALY

1.01e-031635439195051d6bcdd450ed745a099828a0d76d9d3f0b
ToppCell343B-Fibroblasts-Fibroblast-D|343B / Donor, Lineage, Cell class and subclass (all cells)

NRXN2 ADAM33 AKAP12

1.01e-03163543acfb2ece6202479e615d54fd3ecb8b4a571b5a18
ToppCellControl-APC-like-Monocytes|Control / group, cell type (main and fine annotations)

TDRD5 ZNF805 TRAPPC6A

1.01e-031635434bc80a2c741d462724b6f3902377d48c57478932
ToppCell356C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FILIP1 ZNF837 SLC4A3

1.03e-03164543fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|356C / Donor, Lineage, Cell class and subclass (all cells)

PPP1R26 ADPRH ZNF75D

1.05e-0316554335a6de30438de364ccca948fc932da541a69ef89
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AFDN SLC4A3 AKAP12

1.08e-03167543ecdbfde870a2a44c44b9dd65a8737afc6fbf816c
ToppCellBAL-Severe-undefined-undefined-undefined|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KLHL29 ZNF837 AKAP12

1.10e-031685435a1121cc268720d1c0a243e2faab5cf011c20a83
ToppCellBAL-Severe-undefined-undefined-undefined-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KLHL29 ZNF837 AKAP12

1.10e-0316854315df45e053657150f7b188e407e946571745c09e
ToppCellBAL-Severe-undefined-undefined|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KLHL29 ZNF837 AKAP12

1.10e-03168543460dcefbd3d9eb1064986cd66b2ca4b1408ba87d
ToppCellBAL-Severe-undefined-undefined|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KLHL29 ZNF837 AKAP12

1.10e-03168543cb5fccac64bfea18d5607fb232e024d1f7149450
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

KLHL29 ZNF536 AHNAK

1.10e-031685432fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellBAL-Severe-undefined|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KLHL29 ZNF837 AKAP12

1.10e-031685435bf0a389d9813cc9d87afc8d003c20f028cda902
ToppCellBAL-Severe-undefined|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KLHL29 ZNF837 AKAP12

1.10e-0316854393f77a6cad04d14bfa01bb98ff169f668a6ad659
ToppCellBAL-Severe-undefined-undefined-undefined-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KLHL29 ZNF837 AKAP12

1.10e-03168543b020f371e70b4ac60e7027a359e3195611c8ed33
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ZNF536 COL27A1 AKAP12

1.10e-03168543a086c306be430adf0632ba53e98cd8014d2de330
ToppCellBAL-Severe-undefined-undefined-undefined|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KLHL29 ZNF837 AKAP12

1.10e-031685435d8ef76247c0afa9b196ebc5665228b026c49b30
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZNF536 ADAM33 COL25A1

1.12e-031695436a2ef66d7ff69a92e8c62759482e823a07352440
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_104|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL27A1 ADAM33 COL25A1

1.12e-031695436ff1172da690ca17f7108f1617b255b766971a57
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ZNF536 APC COL25A1

1.12e-03169543c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCellfacs-Marrow-B-cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK CALY EFHB

1.14e-031705436e82e41acd1299aa549a32ac036b39754abdf376
ToppCellfacs-Marrow-B-cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK CALY EFHB

1.14e-0317054318cd941bf3ca7cc0b6af1317bd2619d283353de0
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF536 COL27A1 ADAM33

1.14e-03170543b5b47fe42617a4c2ebb49c8ed55db3926213a75a
ToppCellfacs|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB21 SKIL AKAP12

1.16e-031715435bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FILIP1 TEF KLB

1.20e-03173543ef8d720b99470fe1953661f6e66bc0366266bdb6
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GON4L METTL8 AXIN1

1.20e-03173543c31076c725f4cd912c56903592a2d9356ae59f54
ToppCellfacs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GON4L METTL8 AXIN1

1.20e-03173543a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

AKAP6 ZNF536 ADAM33

1.20e-03173543a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellLV-11._Adipocyte|LV / Chamber and Cluster_Paper

KLHL29 AKAP12 KLB

1.20e-03173543c2d3fcb3de71015d03d14c63450853d2b03ffa71
Drugtricapryl(methyl)ammonium

HBB HBD

5.32e-062532CID011071504
Drugallyl 2,4,6-tribromophenyl ether

HBB HBD

5.32e-062532CID000076767
Drug1,3,5-tribromobenzene

HBB HBD

5.32e-062532CID000012279
DrugAC1L3OJQ

HBB HBD

5.32e-062532CID000119294
Drugpentabromobenzene

HBB HBD

5.32e-062532CID000011854
Drugtribromobenzene

HBB HBD

5.32e-062532CID000011842
DrugBromkal 73-5 PE

HBB HBD

5.32e-062532CID000118216
Drug2-(alpha-hydroxybenzyl)-benzimidazole

HBB HBD

5.32e-062532CID000005792
DrugNSC-334295

HBB HBD

5.32e-062532CID000100107
DrugChrysin [480-40-0]; Down 200; 15.8uM; MCF7; HT_HG-U133A

ZSWIM8 SMCHD1 PHACTR4 APC AKAP12 PRRC2B

6.18e-061965365505_DN
Drug1w22

TEF HBB HBD

9.48e-0618533CID000449096
Drugmagnesium acetate tetrahydrate

DAP HBB HBD

1.32e-0520533CID000134717
Drugfuryl-dihydropyridine I

HBB HBD

1.59e-053532CID000125806
DrugNx-D

HBB HBD

1.59e-053532CID006914638
Drugmer13

HBB HBD

1.59e-053532CID000107453
DrugBTBPE

HBB HBD

1.59e-053532CID000037840
Drugpentabromoethylbenzene

HBB HBD

1.59e-053532CID000006800
DrugAC1L4CDO

HBB HBD

3.18e-054532CID000154482
DrugHPED

HBB HBD

3.18e-054532CID000125856
DrugPTU-23

HBB HBD

3.18e-054532CID000853760
DrugAC1L9JVG

HBB HBD

3.18e-054532CID000446603
Drug4-(2-carboxyvinyl)benzoic acid

HBB HBD

3.18e-054532CID000089196
Drug1,4-dibromobenzene

HBB HBD

3.18e-054532CID000007804
Drug1,2,4,5-tetrabromobenzene

HBB HBD

3.18e-054532CID000012486
Drugtallimustine

TCF20 HBB HBD

3.35e-0527533CID000065924
Drugurobilinogen

LDHAL6A HBB HBD

3.74e-0528533CID000026818
DrugAC1L8TD7

HBB HBD

5.29e-055532CID000407802
Drugarildone

HBB HBD

5.29e-055532CID000041782
Drug1,2,4-tribromobenzene

HBB HBD

5.29e-055532CID000012002
DrugCaBr2

HBB HBD

5.29e-055532CID000024608
DrugHexbbp

HBB HBD

5.29e-055532CID000119134
Drug2,4-pentanediol

HBB HBD

7.93e-056532CID000012262
Drugpentabromotoluene

HBB HBD

7.93e-056532CID000006906
DrugAC1LDLU6

HBB HBD

7.93e-056532CID000620919
DrugBP-6

IGFBP2 HBB HBD

8.75e-0537533CID000446948
Drugglycidamide

IGFBP2 APC HBB HBD

9.39e-05102534CID000091550
DrugMeclofenoxate hydrochloride [3685-84-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A

ZSWIM8 AHNAK APC AFDN AXIN1

9.44e-051975354729_UP
DrugCytisine (-) [485-35-8]; Up 200; 21uM; PC3; HT_HG-U133A

ZSWIM8 AHNAK APC CASP4 SLC4A3

9.67e-051985355739_UP
DrugTacrine hydrochloride hydrate [1684-40-8]; Up 200; 15.8uM; PC3; HT_HG-U133A

TAF6L ZSWIM8 AHNAK APC SKIL

9.67e-051985356698_UP
DrugAzathioprine [446-86-6]; Up 200; 14.4uM; PC3; HG-U133A

TAF6L SUOX SMCHD1 AKAP12 PRRC2B

9.67e-051985351945_UP
DrugDicumarol [66-76-2]; Up 200; 11.8uM; PC3; HT_HG-U133A

TAF6L ZSWIM8 AFDN TEF HBB

9.67e-051985353766_UP
Druguric acid

LDHAL6A NRXN2 SUOX HBB HBD

9.90e-05199535CID000001175
Drugflourish

TEF HBB HBD

1.03e-0439533CID000009291
Drugmedrylamine

HBB HBD

1.11e-047532CID000010669
Drugpurpald

HBB HBD

1.11e-047532CID002723946
DrugHBBA

HBB HBD

1.11e-047532CID016072199
DrugSV-4814

HBB HBD

1.11e-047532CID003010509
DrugViroxime

HBB HBD

1.11e-047532CID000051567
Drugtrimesic acid

HBB HBD

1.11e-047532CID000011138
Drug4-nitrosobiphenyl

HBB HBD

1.11e-047532CID000024971
DrugAC1L2B9U

HBB HBD

1.48e-048532CID000044164
DrugL 35

HBB HBD

1.48e-048532CID000195347
DrugP-15

CDK12 DAP HBB HBD MIER1

1.65e-04222535CID000200884
Drugflavins

TCF20 SUOX HBB HBD

1.88e-04122534CID005326566
Drug4-sulfophenyl isothiocyanate

HBB HBD

1.89e-049532CID000087189
DrugN,N-diethylphenylacetamide

HBB HBD

1.89e-049532CID000017076
DrugOP-2507

HBB HBD

1.89e-049532CID006438365
Drug3H-AMT

HBB HBD

1.89e-049532CID000107680
DrugAC1L252K

HBB HBD

1.89e-049532CID000015061
DrugHS 4

HBB HBD

2.36e-0410532CID005493398
Drugdecabromodiphenyl

HBB HBD

2.36e-0410532CID000026164
Drugferrous succinate

HBB HBD

2.36e-0410532CID000159252
Drug1-butyl-3-methylimidazolium hexafluorophosphate

HBB HBD

2.36e-0410532CID002734174
DrugAC1LADZE

HBB HBD

2.36e-0410532CID000486298
Drughexabromobenzene

HBB HBD

2.36e-0410532CID000006905
Drug1q65

IGFBP2 HBB HBD

2.72e-0454533CID000448017
DrugTTAB

HBB HBD

2.89e-0411532CID000014250
Drugsyntometrine

HBB HBD

2.89e-0411532CID011979741
Drug2,6-dihydroxyacetophenone

HBB HBD

2.89e-0411532CID000069687
DrugNFPLP

HBB HBD

2.89e-0411532CID006451852
DrugN-(2-hydroxypropyl)valine

HBB HBD

2.89e-0411532CID000130204
Drug4-dimethylaminophenol

HBB HBD

2.89e-0411532CID000022173
Drugpotassium ferricyanide

TCF20 HBB HBD

3.03e-0456533CID000026250
Drugalpha-hydroxybutyrate

LDHAL6A HBB HBD

3.03e-0456533CID000011266
Drugsulfur dioxide

SUOX HBB HBD

3.36e-0458533CID000001119
Drug2-hydroxylamino-5-ethyl-5-propylbarbituric acid

HBB HBD

3.46e-0412532CID000128182
DrugFerastral

HBB HBD

3.46e-0412532CID000171553
Drug7-methylguanosine 5'-phosphate

HBB HBD

3.46e-0412532CID000440190
Drugsilver fluoride

HBB HBD

3.46e-0412532CID000062656
Drug3-methacryloxypropyltrimethoxysilane

HBB HBD

3.46e-0412532CID000017318
Drugp-nitrophenacyl bromide

HBB HBD

3.46e-0412532CID000066840
DrugHb Q

HBB HBD

3.46e-0412532CID000154048
Drugthioxoboron

LDHAL6A HBB HBD

3.53e-0459533CID006327264
Drugbendazac

TCF20 ZBTB21

4.08e-0413532CID000002313
Drugpentafluorophenyl isothiocyanate

HBB HBD

4.08e-0413532CID000123452
Drugketononestrol aziridine

HBB HBD

4.08e-0413532CID000130642
Drug3-aminobiphenyl

HBB HBD

4.08e-0413532CID000016717
DrugAC1O4686

HBB HBD

4.08e-0413532CID006379235
Drug(N5,C4a)-(Alpha-Hydroxy-Propano)-3,4,4a,5-Tetrahydro-Flavin-Adenine Dinucleotide

HBB HBD

4.08e-0413532CID005494420
Drug3-mercaptolactic acid

LDHAL6A SUOX

4.08e-0413532CID000160645
Drugsodium ferric gluconate

HBB HBD

4.08e-0413532CID011254352
Drugcrystal violet

DAP HBB HBD

4.29e-0463533CID000003468
DrugHS 3

HBB HBD

4.75e-0414532CID003060736
DrugS-7HNa

HBB HBD

4.75e-0414532CID000188208
Drug6-amino-m-cresol

HBB HBD

4.75e-0414532CID000076082
DrugAC1L5F7F

LDHAL6A HBB HBD

4.91e-0466533CID000227041
DrugE 64

LDHAL6A CASP4 HBB HBD

5.39e-04161534CID000123985
Drugdiacetyldeuteroheme

HBB HBD

5.48e-0415532CID004629150
DrugPBBs

HBB HBD

5.48e-0415532CID000158629
DrugPD 128907

HBB HBD

5.48e-0415532CID000005117
DiseaseDelta-Beta Thalassemia

HBB HBD

9.13e-063522C0271985
Diseasebeta thalassemia (implicated_via_orthology)

HBB HBD

9.13e-063522DOID:12241 (implicated_via_orthology)
DiseaseIntellectual Disability

AKAP6 TCF20 WDR4 NRXN2 APC GON4L TRAPPC6A

1.30e-05447527C3714756
DiseaseChloracne

AHNAK HBB HBD

2.71e-0533523C0263454
Diseasehemoglobin measurement, hemoglobin A2 measurement

HBD HBD

3.04e-055522EFO_0004509, EFO_0005845
Diseasehemoglobin E disease

HBD HBD

4.55e-056522MONDO_0016243
DiseaseHepatoblastoma

APC AXIN1

4.55e-056522C0206624
Diseaseanemia (biomarker_via_orthology)

HBB HBD

6.36e-057522DOID:2355 (biomarker_via_orthology)
DiseaseHEPATOCELLULAR CARCINOMA

APC AXIN1

1.09e-049522114550
Diseaseresponse to tamoxifen

TCF20 TEF

1.09e-049522EFO_0009391
DiseaseHepatocellular carcinoma

APC AXIN1

1.09e-049522cv:C2239176
Diseaseanemia (implicated_via_orthology)

APC SLC4A3

3.15e-0415522DOID:2355 (implicated_via_orthology)
DiseaseTourette syndrome, schizophrenia

ZNF536 TCF20

4.58e-0418522EFO_0004895, MONDO_0005090
Diseasecortical surface area measurement

KLHL29 FILIP1 ZNF536 SUOX RP1L1 APC TEF PRR3 AXIN1

5.18e-041345529EFO_0010736
DiseaseAdenocarcinoma of large intestine

CDK12 APC AXIN1

6.57e-0496523C1319315
DiseaseSplenomegaly

APC HBB

6.88e-0422522C0038002
DiseaseVitiligo

ADPRH SUOX TEF

7.62e-04101523EFO_0004208
Diseaseblood urea nitrogen measurement

CDK12 GON4L TEF MIER1 KLB

1.19e-03452525EFO_0004741

Protein segments in the cluster

PeptideGeneStartEntry
PLQAKMGKGGDAASH

TDRD5

746

Q8NAT2
MLPPGAQHSDEKGAK

AFDN

301

P55196
TKAGHPPAVKAGGMR

DAP

11

P51397
KEKPLHMPGGDGHRG

SLC4A3

486

P48751
MPNSERHGGKKDGSG

CDK12

1

Q9NYV4
EGGPKAMGGDHQKAD

AKAP12

701

Q02952
KKAHPNMEAGPPESG

CASP4

86

P49662
AKGEGPDVHMTLPKG

AHNAK

641

Q09666
HRDPGNKAGMTSLPG

ADAM33

181

Q9BZ11
LKPKGPHSQEGDTLM

OR10H2

261

O60403
QMGKGGKHHLGLEEP

IGFBP2

201

P18065
PKGDKGEQGDQGPRM

COL25A1

151

Q9BXS0
LGNGPSLMKGNSDKP

NRXN2

981

Q9P2S2
DPGLPAKKAGMQAGD

PDZD3

361

Q86UT5
GGEDPGKPSDAMLKN

PHACTR4

91

Q8IZ21
AGGPAPAGAAKMKVV

GNPTG

16

Q9UJJ9
KPGKDPGDQDGAAMD

CALY

11

Q9NYX4
KMPVALGGAASGHGK

AXIN1

501

O15169
ASPMPGAKEAGQGKD

GON4L

1901

Q3T8J9
SPGKAHDGAKGDMGL

COL27A1

681

Q8IZC6
GKSHDQAPGLPKGMD

EFHB

366

Q8N7U6
GTGMHAPGEKGNLAA

KLB

251

Q86Z14
SPDAVMGNPKVKAHG

HBD

51

P02042
TPDAVMGNPKVKAHG

HBB

51

P68871
HKKGPMETGLFPGSN

METTL8

181

Q9H825
GGNKKPLHADMDTNG

MIER1

431

Q8N108
KMKAQAAEPNRGGPG

TAF6L

371

Q9Y6J9
KGEAMQKLPGTSHGG

SMCHD1

726

A6NHR9
KKLNGMGDDGSPPAK

SKIL

16

P12757
MKAGKPVVAAPGAGN

FILIP1

1166

Q7Z7B0
MTAQPGPGHGKKLGH

PIP5K1C

46

O60331
MANGKPGDPKSALHR

PRR3

46

P79522
MSDAGGGKKPPVDPQ

TEF

1

Q10587
TKTMDPGPGGLDTDH

PPP1R26

431

Q5T8A7
SGKPGESGMPEEHNA

AKAP6

2256

Q13023
GASVHNAMQLKPGKP

ADPRH

101

P54922
LKGDNEKHSPRNMGG

APC

2056

P25054
MEAPAQKAGQGGLPK

ZNF837

1

Q96EG3
LGNEAGAGAMSHPKP

PNMA5

431

Q96PV4
AMDDKPGVSGQLPKG

ZBTB21

251

Q9ULJ3
GLEKPPGATMMGQEH

RP1L1

1476

Q8IWN7
GGSNKPQHMAEEGPG

ZNF646

1131

O15015
MSGPGLAEPKADSHK

PRRC2B

1701

Q5JSZ5
SSDGLPNKGMELKHG

TCF20

1166

Q9UGU0
HDPDPGPGGQKMSLS

TRAPPC6A

21

O75865
LADPPSMKVHGVDGG

ZNF536

941

O15090
LSAEGGDKALHKMGP

ZSWIM8

566

A7E2V4
LMDLHGKGPTGEKPF

ZNF75D

351

P51815
PDGHAKKMRPGEATL

WDR4

396

P57081
DLHPGGPSKLMLAAG

SUOX

116

P51687
PGKMSPKHDGLGTAD

ZNF805

151

Q5CZA5
DSQLKHGAPRPGMKS

USP54

1271

Q70EL1
PEKGNIKAGPNMNHS

KLHL29

796

Q96CT2
GKLKGETMDLQHGSP

LDHAL6A

56

Q6ZMR3