Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

FOXE1 SOX5 MYF5 FOXD3 SOX21 GCM2 SPIB EGR2 NKX2-3 ZBTB47 SP5 ESX1 FOXI3 HES2 IRX2 PROP1 FOXC2

2.11e-0514127717GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

FOXE1 SOX5 MYF5 FOXD3 SOX21 GCM2 SPIB EGR2 NKX2-3 SP5 FOXI3 HES2 IRX2 PROP1 FOXC2

6.92e-0512447715GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

FOXE1 SOX5 MYF5 FOXD3 SOX21 GCM2 SPIB EGR2 NKX2-3 SP5 FOXI3 HES2 IRX2 PROP1 FOXC2

8.82e-0512717715GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

FOXE1 SOX5 MYF5 FOXD3 SOX21 GCM2 SPIB EGR2 NKX2-3 SP5 ESX1 FOXI3 HES2 IRX2 PROP1 FOXC2

1.17e-0414597716GO:0000977
GeneOntologyCellularComponentchromatin

FOXE1 SOX5 MYF5 FOXD3 SOX21 GCM2 SPIB EGR2 NKX2-3 SP5 ESX1 PRAMEF12 HES2 IRX2 PROP1 FOXC2

8.11e-0514807716GO:0000785
DomainTF_fork_head_CS_2

FOXE1 FOXD3 FOXI3 FOXC2

3.82e-0546774IPR030456
DomainTF_fork_head_CS_1

FOXE1 FOXD3 FOXI3 FOXC2

4.16e-0547774IPR018122
DomainFH

FOXE1 FOXD3 FOXI3 FOXC2

4.91e-0549774SM00339
DomainFORK_HEAD_1

FOXE1 FOXD3 FOXI3 FOXC2

4.91e-0549774PS00657
DomainFORK_HEAD_2

FOXE1 FOXD3 FOXI3 FOXC2

4.91e-0549774PS00658
DomainFork_head_dom

FOXE1 FOXD3 FOXI3 FOXC2

4.91e-0549774IPR001766
DomainFORK_HEAD_3

FOXE1 FOXD3 FOXI3 FOXC2

4.91e-0549774PS50039
DomainForkhead

FOXE1 FOXD3 FOXI3 FOXC2

4.91e-0549774PF00250
DomainFurin-like

ERBB2 IGF1R

3.48e-047772PF00757
DomainRcpt_L-dom

ERBB2 IGF1R

3.48e-047772IPR000494
DomainFurin-like_Cys-rich_dom

ERBB2 IGF1R

3.48e-047772IPR006211
DomainRecep_L_domain

ERBB2 IGF1R

3.48e-047772PF01030
Domain-

ERBB2 IGF1R

3.48e-0477723.80.20.20
DomainGrowth_fac_rcpt_

HSPG2 ERBB2 FBLN5 IGF1R DLL1

4.64e-04156775IPR009030
Pubmed

A census of human transcription factors: function, expression and evolution.

FOXE1 SOX5 MYF5 FOXD3 RC3H2 SOX21 GCM2 EGR2 NKX2-3 SP5 ESX1 FOXI3 HES2 IRX2 PROP1 FOXC2

1.55e-10908781619274049
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

FOXE1 FOXD3 GCM2 SPIB EGR2 NKX2-3 ESX1 HES2 PROP1 FOXC2

3.92e-07544781028473536
Pubmed

The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.

MYF5 DLL1 FOXC2

4.84e-061578312925591
Pubmed

Direct interaction of the extracellular matrix protein DANCE with apolipoprotein(a) mediated by the kringle IV-type 2 domain.

FBLN5 LPA

4.97e-06278212111551
Pubmed

Altered binding of MYF-5 to FOXE1 promoter in non-syndromic and CHARGE-associated cleft palate.

FOXE1 MYF5

4.97e-06278219192046
Pubmed

Superior antitumor activity of a novel bispecific antibody cotargeting human epidermal growth factor receptor 2 and type I insulin-like growth factor receptor.

ERBB2 IGF1R

4.97e-06278224227890
Pubmed

Human venous valve disease caused by mutations in FOXC2 and GJC2.

GJC2 FOXC2

4.97e-06278228724617
Pubmed

Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma.

ERBB2 IGF1R

4.97e-06278221447712
Pubmed

Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

ERBB2 IGF1R

4.97e-06278221862872
Pubmed

Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.

ERBB2 IGF1R

4.97e-06278217761519
Pubmed

Identification of disease-specific genes in chronic pancreatitis using DNA array technology.

CELA2A CRISP3

4.97e-06278211729383
Pubmed

Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles.

ERBB2 RB1CC1

4.97e-06278233472043
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HSPG2 MYOF ERBB2 IGF1R TBKBP1 SLC12A4 PCNX3 SPEG DUSP5 ZDHHC5 DLL1 HES2

6.28e-061105781235748872
Pubmed

Schwann cell myelination requires integration of laminin activities.

HSPG2 ERBB2 EGR2

1.40e-052178322767514
Pubmed

Epidermal growth factor receptor (EGFR), HER2 and insulin-like growth factor-1 receptor (IGF-1R) status in ovarian adult granulosa cell tumours.

ERBB2 IGF1R

1.49e-05378224206174
Pubmed

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer.

ERBB2 IGF1R

1.49e-05378224655723
Pubmed

Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R.

ERBB2 IGF1R

1.49e-05378224571711
Pubmed

The EGF receptor interacts with the type 1 IGF receptor and regulates its stability.

ERBB2 IGF1R

1.49e-05378217307140
Pubmed

Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin.

ERBB2 IGF1R

1.49e-05378220103628
Pubmed

Dual inhibition of IGF1R and ER enhances response to trastuzumab in HER2 positive breast cancer cells.

ERBB2 IGF1R

1.49e-05378228498399
Pubmed

Myoferlin is required for insulin-like growth factor response and muscle growth.

MYOF IGF1R

1.49e-05378220008164
Pubmed

Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer.

ERBB2 IGF1R

1.49e-05378218483367
Pubmed

Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.

ERBB2 IGF1R

1.49e-05378214697248
Pubmed

SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells.

SOX5 SOX21

1.49e-05378228687615
Pubmed

Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.

FOXE1 FOXC2

2.97e-05478227783871
Pubmed

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.

ERBB2 IGF1R

2.97e-05478225241146
Pubmed

Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation.

ERBB2 IGF1R

2.97e-05478231318186
Pubmed

Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B.

SPIB DLL1

2.97e-05478216317090
Pubmed

The developmental basis for scaling of mammalian tooth size.

IGF1R FOXI3

2.97e-05478237307487
Pubmed

Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells.

ERBB2 IGF1R

2.97e-05478221943825
Pubmed

Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity.

ZDHHC5 CTNND2

2.97e-05478224562000
Pubmed

Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.

IGF1R PROP1

2.97e-05478237441495
Pubmed

Insulin-like growth factor-1 receptor signaling increases the invasive potential of human epidermal growth factor receptor 2-overexpressing breast cancer cells via Src-focal adhesion kinase and forkhead box protein M1.

ERBB2 IGF1R

2.97e-05478225391374
Pubmed

The transcription factor NKX2-3 mediates p21 expression and ectodysplasin-A signaling in the enamel knot for cusp formation in tooth development.

HSPG2 NKX2-3

2.97e-05478230089653
Pubmed

An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer.

ERBB2 EGR2

2.97e-05478217938205
Pubmed

Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3.

MYF5 ERBB2

4.94e-05578219369542
Pubmed

Analysis of expression of membrane-bound tumor markers in ductal carcinoma in situ of the breast: paving the way for molecular imaging.

ERBB2 IGF1R

4.94e-05578223744486
Pubmed

VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development.

MYF5 DLL1

4.94e-05578219118645
Pubmed

Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival.

MYF5 ERBB2

4.94e-05578219954518
Pubmed

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria.

TBKBP1 RB1CC1

7.40e-05678230853402
Pubmed

Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma.

ERBB2 IGF1R

7.40e-05678219812598
Pubmed

Limits to in vivo fate changes of epithelia in thymus and parathyroid by ectopic expression of transcription factors Gcm2 and Foxn1.

GCM2 GZMA

7.40e-05678235941210
Pubmed

The somatotropic axis and longevity in mice.

IGF1R PROP1

7.40e-05678226219867
Pubmed

A genome-wide scan maps a novel high myopia locus to 5p15.

CTNND2 IRX2

7.40e-05678218421076
Pubmed

A complex oscillating network of signaling genes underlies the mouse segmentation clock.

HSPG2 TLR5 SP5

7.98e-053778317095659
Pubmed

Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice.

ERBB2 CHRNE

1.04e-04778216203963
Pubmed

The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.

IGF1R BCL2L10

1.04e-04778228075048
Pubmed

ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3.

TBKBP1 CTNND2

1.04e-04778219481056
Pubmed

Genetic mouse models of extended lifespan.

IGF1R PROP1

1.04e-04778214698816
Pubmed

The retardation of aging by caloric restriction: its significance in the transgenic era.

IGF1R PROP1

1.04e-04778214698815
Pubmed

Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.

IGF1R LPA

1.38e-0487829438420
Pubmed

Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.

HSPG2 CHRNE

1.38e-04878226993635
Pubmed

A conserved family of genes related to the testis determining gene, SRY.

SOX5 SOX21

1.38e-0487821614875
Pubmed

Expression of mouse Foxi class genes in early craniofacial development.

EGR2 FOXI3

1.38e-04878215376323
Pubmed

Maintenance of somite borders in mice requires the Delta homologue DII1.

MYF5 DLL1

1.38e-0487829109488
Pubmed

The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development.

FOXD3 EGR2

1.77e-0497829767163
Pubmed

Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.

ERBB2 IGF1R

1.77e-04978224285539
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

MYOF ERBB2 SLC12A4 PCNX3 ZDHHC5 SLC23A2

2.08e-0437778638117590
Pubmed

Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.

IGF1R GCM2 DLL1

2.09e-045178319164599
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

CFH ERBB2 IGF1R RB1CC1 SLC23A2 ABCG8

2.20e-0438178618676680
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

DLL1 HES2

2.21e-041078224015274
Pubmed

Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.

MYF5 HSPG2

2.21e-041078216554364
Pubmed

Distinct Roles of Transcription Factors KLF4, Krox20, and Peroxisome Proliferator-Activated Receptor γ in Adipogenesis.

MYF5 EGR2

2.21e-041078227777310
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

CFH ERBB2 IGF1R RB1CC1 SLC23A2 ABCG8

2.23e-0438278619170196
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

SOX5 MYF5 IGF1R EGR2 PROP1 FOXC2

2.26e-0438378619453261
Pubmed

Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

FOXD3 FOXC2

2.70e-04117827683413
Pubmed

Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development.

ERBB2 CHRNE

2.70e-041178210521398
Pubmed

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.

ERBB2 EGR2

2.70e-041178223792428
Pubmed

Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis.

FOXE1 FOXC2

2.70e-041178228506991
Pubmed

Zic2 is required for neural crest formation and hindbrain patterning during mouse development.

FOXD3 EGR2

2.70e-041178214651926
Pubmed

The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm.

MYF5 DLL1

3.23e-041278211124811
Pubmed

A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool.

ERBB2 EGR2

3.23e-041278210704452
Pubmed

SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system.

SOX5 EGR2

3.23e-041278234234180
Pubmed

Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression.

DLL1 PROP1

3.23e-041278214732396
Pubmed

Accelerated failure time models provide a useful statistical framework for aging research.

IGF1R PROP1

3.23e-041278219007875
Pubmed

Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.

MYF5 DLL1

3.23e-041278217572911
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

ERBB2 IGF1R RNF125 MYO9A DUSP5 NOSIP

3.69e-0442078628065597
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

CFH ERBB2 IGF1R RB1CC1 SLC23A2 ABCG8

3.74e-0442178619692168
Pubmed

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.

ERBB2 EGR2

3.81e-041378229748249
Pubmed

Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development.

SOX5 MYF5

3.81e-041378215634692
Pubmed

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo.

MYF5 FOXC2

3.81e-041378221143873
Pubmed

Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation.

MYF5 DLL1

3.81e-041378218708576
Pubmed

Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord.

FOXD3 DLL1

3.81e-041378221124801
Pubmed

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements.

SOX5 SOX21

3.81e-041378222344693
Pubmed

Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.

SOX5 SOX21

3.81e-041378212194848
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

MYF5 FOXD3 RNF125 ESX1 PRAMEF12 IRX2

3.88e-0442478621731673
Pubmed

Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.

IGF1R GZMA

4.44e-04147821354647
Pubmed

Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.

EGR2 DLL1

4.44e-041478218703040
Pubmed

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.

FOXD3 SP5

4.44e-041478217360769
Pubmed

Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model.

MYF5 FOXD3

4.44e-041478230683671
Pubmed

Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.

ERBB2 SPIB

4.44e-041478214635793
Pubmed

Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.

MYF5 HSPG2

4.44e-041478219783738
Pubmed

Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters.

MYF5 CHRNE

4.44e-041478229323161
Pubmed

Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.

CFH FBLN5

4.44e-041478219015224
Pubmed

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development.

SOX5 HSPG2

4.44e-041478228011632
Pubmed

Tie2 regulates endocardial sprouting and myocardial trabeculation.

HSPG2 ERBB2 DLL1

4.90e-046878331112136
Pubmed

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

MYOF ERBB2 IGF1R

5.11e-046978326792178
Pubmed

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.

GCM2 FOXI3

5.12e-041578216530750
Pubmed

Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.

EGR2 ESX1

5.12e-041578211353388
Pubmed

Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.

MYF5 DLL1

5.12e-041578217194759
GeneFamilyForkhead boxes

FOXE1 FOXD3 FOXC2

3.35e-0443573508
GeneFamilySRY-boxes

SOX5 SOX21

1.61e-0319572757
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_OMD_POS_ENDOTHELIAL_CELL

CFH SOX5 IL11RA ERBB2 FBLN5 SPEG TLR5 FOXC2

1.08e-05355788M45758
CoexpressionGSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_C57BL6_DN

FBLN5 MYO9A DUSP5 GZMA RB1CC1 DLL1

1.45e-05176786M8790
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

FOXE1 FOXD3 ESX1 LGR6 HES2 IRX2 FOXC2

1.69e-05272787M1938
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

FOXE1 FOXD3 ESX1 LGR6 HES2 IRX2 FOXC2

2.13e-05282787MM822
CoexpressionGSE15930_NAIVE_VS_72H_IN_VITRO_STIM_CD8_TCELL_UP

CFH RASGRF2 GZMA CELA2A ZDHHC5 HES2

2.98e-05200786M3605
ToppCellNS-critical-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFH HSPG2 ERBB2 FCGBP SLC12A4 FOXC2

5.28e-07169786aec97583b23112060437b619cb429dc32f29285f
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CFH IL11RA HSPG2 FBLN5 NKX2-3 FOXC2

7.39e-071797868c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

CFH SOX5 IL11RA HSPG2 MYOF FBLN5

1.11e-061927867e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RNF125 PDLIM7 SPEG GZMA GJC2

6.26e-06148785065177aaa63c0441d312260b43ecdac78c84ad03
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

PDLIM7 SPEG DCLK2 LGR6 FOXC2

1.30e-05172785c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNPLA1 GALNT11 SPEG TLR5 CTNND2

1.33e-0517378526bba58f9fb215d1d155504906cd77e8774f6936
ToppCelldroplet-Lung-LUNG-1m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PNPLA1 GALNT11 SPEG TLR5 CTNND2

1.33e-0517378569b404e92aad3e6dff67e75466f073f20a71f13f
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH HSPG2 FBLN5 SP5 FOXC2

1.37e-051747852891ab2fd05eb4bbd239d1a2865f21ef7f2df39e
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH HSPG2 FBLN5 SP5 FOXC2

1.37e-05174785eade55f86ef1f7a5355ad65cec3aa6bfc5d3c62d
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CFH IL11RA HSPG2 FBLN5 FOXC2

1.45e-0517678552af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-nan|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL11RA FCGBP CELA2A CRISP3 SERPINA9

1.66e-0518178575340f0c06977c88f9d2e56265f4aa84d706d2c6
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFH LRP12 PCNX3 GZMA LGR6

1.75e-0518378590c66ffd2c1f87c91f9a9886e28aeec542f9df85
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH IL11RA FBLN5 PDLIM7 FOXC2

1.84e-051857857b1c5d99bd7a6e148524029758cee244a17f5d09
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH IL11RA FBLN5 PDLIM7 FOXC2

1.84e-05185785e9033a03d574956cf3ae228740b3166e40a6397f
ToppCellMonocytes-IL1B+_Monocytes|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SPIB EGR2 DUSP5 IER5 CHRNE

1.84e-05185785cbe54b605f417a01b3b5d2ec75565ee3b5a9ba06
ToppCell3'-Distal_airway-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH IL11RA FBLN5 PDLIM7 FOXC2

1.84e-05185785578f12c6b2e33d09598dc8e022a20c8555d1325c
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HSPG2 MYOF ERBB2 MYO9A IRX2

1.89e-051867853aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCellE12.5-Epithelial-epithelial_progenitor_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FOXD3 ARRDC1 SP5 CTNND2 IRX2

1.94e-05187785ab6f4d387218b4651fdadbf269806c1ddc96a1d2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

IGF1R RNF125 RASGRF2 GZMA NOSIP

2.04e-051897855a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SOX5 PDLIM7 SPEG LGR6 FOXC2

2.04e-05189785127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SOX5 PDLIM7 SPEG LGR6 FOXC2

2.04e-051897852cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

CFH SOX5 HSPG2 FBLN5 RASGRF2

2.10e-051907851519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCelldroplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL11RA HSPG2 FBLN5 GJC2 FOXC2

2.10e-05190785f50b9814a1beac67dc042a8c27dfd085ceeda3a6
ToppCelldroplet-Lung-21m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL11RA HSPG2 FBLN5 GJC2 FOXC2

2.10e-05190785a22a510b4a257eb0eaf09c7ae7978d3d2f07a58c
ToppCelldroplet-Lung-21m-Endothelial-lymphatic_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL11RA HSPG2 FBLN5 GJC2 FOXC2

2.10e-0519078557c136bf6d7feafb4a220877bed0cc8fdf314db2
ToppCellfacs-Thymus-Epithelium-24m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 CELA2A TLR5 BBS1 IRX2

2.15e-05191785eec14997d2bfc7e6b5a601afc43a147f6b96d668
ToppCellfacs-Thymus-Epithelium-24m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 CELA2A TLR5 BBS1 IRX2

2.15e-051917851730ec5dc1cfd2f0cba7e21555641c7bce97e09d
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX5 MYOF SPEG LGR6 FOXC2

2.15e-0519178508042952431ca1a6fd7dfc13f36eb28643979598
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX5 MYOF SPEG LGR6 FOXC2

2.15e-051917857853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCellfacs-Thymus-Epithelium-24m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 CELA2A TLR5 BBS1 IRX2

2.15e-051917854b77abc68bd72c64e7062f9527fe9d9605289ceb
ToppCellIPF-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

HAVCR2 IGF1R GSE1 GZMA LGR6

2.15e-05191785f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

SOX5 PDLIM7 SPEG LGR6 FOXC2

2.15e-05191785fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SOX5 PDLIM7 SPEG LGR6 FOXC2

2.20e-05192785992d08092edbc68c47b945deb8708379738c239a
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FBLN5 IGF1R FCGBP RASGRF2 NOSIP

2.26e-0519378595f5611dd9583f339b7c9f52bb478af204fb89ad
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SOX5 HSPG2 RASGRF2 CTNND2

2.26e-051937852e72309607902dabe3218888b22a77fe941f3570
ToppCellNS-moderate-d_0-4-Myeloid-Resident_Macrophage|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

HAVCR2 FCGBP SPIB DUSP5 CHRNE

2.26e-05193785e530d4349b257f2590c799bf082ed6318700c526
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|bone_marrow / Manually curated celltypes from each tissue

RNF125 GALNT11 DUSP5 GZMA LGR6

2.26e-051937851788f865fc9f9a235dbfaf363ed1985fdc715394
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IGF1R RNF125 RASGRF2 GZMA NOSIP

2.43e-05196785c4e7133c609bcbc48c4947ea0aa1a7d9d7251b04
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a|Striatum / BrainAtlas - Mouse McCarroll V32

PNPLA1 EGR2 DUSP5 SERPINA9

4.05e-05109784e8e0f2c5f8c9e45f2b4d173569c94275eedfe432
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDLIM7 SPEG LGR6 FOXC2

6.49e-0512378487401764a073c1808f214642a9c84299c78f7ec7
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL11RA SLC12A4 IER5 SERPINA9

9.05e-051347846d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SOX5 HSPG2 RNF125

1.04e-04139784b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYOF NWD1 GALK1 DUSP5

1.16e-041437844c5a5db46beb8f2f3c40e8ed95911fbfea61bae0
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MYF5 FOXD3 BCL2L10

1.17e-0454783bd35719debc281b041e627c6c3c96329b97d615e
ToppCellSevere-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SPIB DUSP5 GJC2 DLL1

1.23e-04145784a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Lypd6_(Parafasicular_nucleus_(PF))|Thalamus / BrainAtlas - Mouse McCarroll V32

GCM2 STPG2 PROP1

1.23e-04557837c8da8ca1776bb0abbfcf5c933b8817d64a0d3d7
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2-Th.Adora2a-Th_(Striatum,_Th+_SPN)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MYF5 FOXD3 BCL2L10

1.30e-0456783e6b2f6ff08887ae8335c44d7fff118c371768809
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Adora2a-Excitatory_Neuron.Gad1Gad2-Th.Adora2a-Th_(Striatum,_Th+_SPN)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MYF5 FOXD3 BCL2L10

1.30e-04567837a1f39e2ebe70d757847e4fb02c39313b1ea5a2d
ToppCellIIH-CD8-exh_CD4|IIH / Condition, Cell_class and T cell subcluster

LRP12 GSE1 GZMA NKX2-3

1.55e-04154784a2f51a3c5455fe2483e438375ea856afce8262fe
ToppCellAdult-Epithelial-basal_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH NWD1 LPA DLL1

1.55e-0415478438d346402417960044ae999e61f0092b46f2b591
ToppCellMS-CD8-memory_CD4|MS / Condition, Cell_class and T cell subcluster

SLC12A4 GZMA DLL1 HES2

1.55e-04154784aec893cf3e1cf90e18a9117183fc7a1f397425a9
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH SOX5 SPEG LGR6

1.59e-04155784cd7d95cbcad248670e531d80bb83c55e36ebc573
ToppCellfacs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX5 HAVCR2 DCAF6 CHRNE

1.62e-041567845caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCellfacs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX5 HAVCR2 DCAF6 CHRNE

1.62e-04156784758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCellfacs-SCAT-Fat-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSE1 DUSP5 GZMA CHRNE

1.67e-04157784ad8c6eb34f5288288c4066119c17325afefbaafc
ToppCellFLU-Healthy-1|Healthy / Virus stimulation, Condition and Cluster

HAVCR2 FBLN5 GZMA LGR6

1.75e-0415978497c8e16a7ac10ebba96daee97f9fb1d4a404f23b
ToppCellFLU-Healthy-1|FLU / Virus stimulation, Condition and Cluster

HAVCR2 FBLN5 GZMA LGR6

1.75e-04159784fe2a9f79b058e89214256e736f6e266830cdfa28
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

HSPG2 FBLN5 SP5 FOXC2

1.75e-0415978492049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

PDLIM7 SPEG DCLK2 LGR6

1.79e-04160784d783d29150033e9181c0e30870070268fed3fd85
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX5 SPIB RASGRF2 TNFRSF14

1.83e-04161784249c2b97cc25de5053f5048ee354615df49b2081
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B|367C / Donor, Lineage, Cell class and subclass (all cells)

HAVCR2 RNF125 GZMA LGR6

1.83e-04161784f7dc1e3326ab22f2eb1e94b632469a0682a3289c
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RC3H2 TNFRSF14 ZBTB47 BBS1

1.88e-04162784b502d6af6868425b5c919740e011330c0d3cf3b8
ToppCell390C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SOX5 DNHD1 GZMA NKX2-3

1.88e-0416278445be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell390C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SOX5 DNHD1 GZMA NKX2-3

1.88e-04162784fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCelldroplet-Fat-Gat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH HAVCR2 PNPLA1 CTNND2

1.88e-04162784052f797d8bcab8fc6a43e0bffdd215c88ee12889
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NBPF3 CFH IL11RA ZBTB47

1.92e-041637841feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCell10x5'-blood-Lymphocytic_Invariant-Inducer-like-ILC3|blood / Manually curated celltypes from each tissue

CFH BBS1 CTNND2 DLL1

2.01e-04165784f012a27ece54c0f7b73a2f4f89c6ee8b865f8782
ToppCellsevere_influenza-CD4+_CTL|World / disease group, cell group and cell class (v2)

CFH RNF125 GZMA NKX2-3

2.06e-04166784cdc3e200373718f26fe02ee516928097103f46e2
ToppCellClub-club-2|World / Class top

GARIN5B FCGBP DUSP5 IER5

2.06e-0416678456f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

PDLIM7 SPEG DCLK2 LGR6

2.11e-04167784c4e321bb87512ea839f324c92c0f1afea891483f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HAVCR2 IER5 CTNND2 HES2

2.21e-04169784b2d53159e344fad6fcdc485d5b8f6cf1bf094b1f
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HAVCR2 FCGBP EGR2 IER5

2.21e-041697840867528101767fc65e93b3561480bf830c50368d
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 MYO9A CTNND2 IRX2

2.21e-04169784cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PNPLA1 GALNT11 SPEG TLR5

2.26e-04170784f664c7559e383b37845c123e41a3be316d869ba0
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell|E16.5-samps / Age Group, Lineage, Cell class and subclass

FCGBP ARRDC1 CTNND2 IRX2

2.26e-041707845a64e05c263df915085988d881808221e2c0f2e2
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LPA NKX2-3 DLL1 IRX2

2.26e-04170784a7184dc41f90caa753860ed0f65a18133f84bc5f
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PNPLA1 GALNT11 SPEG TLR5

2.26e-041707840272eb1487c2545d4aa06f5d1cd77f823e1441e9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOX5 HSPG2 FBLN5 BCL2L10

2.31e-04171784972fab891135bd755d5526cbc5a963200067b0a6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SOX5 HSPG2 FBLN5 BCL2L10

2.31e-041717842a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellLV-13._Vascular_Smooth_Muscle|LV / Chamber and Cluster_Paper

SOX5 PDLIM7 CELA2A LGR6

2.31e-04171784e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DCAF6 MYO9A CELA2A

2.41e-04173784869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

PDLIM7 SPEG DCLK2 LGR6

2.41e-04173784a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP SPIB TNFRSF14 NKX2-3

2.41e-041737847c5e4809205ce1a0a301c15442af00a2e2b9b301
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PDLIM7 SPEG DCLK2 LGR6

2.41e-04173784cb6389536195443633adb06e5f1b7483530773d1
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HAVCR2 RNF125 GZMA LGR6

2.41e-0417378436a471576a9d2325066bb14c2f2cd89c67b92915
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DCAF6 MYO9A CELA2A

2.41e-041737840672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DCAF6 MYO9A CELA2A

2.41e-04173784870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell10x5'-blood-Lymphocytic_Invariant-Inducer-like|blood / Manually curated celltypes from each tissue

FOXE1 CFH GZMA CTNND2

2.47e-0417478451be6f29308c01593978cbee92114151a5916c9c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GALK1 PDLIM7 SPEG LGR6

2.52e-04175784b80fe906043b3cb0b3ba761aadc9dc1c364aa1bf
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CFH FCGBP SOX21 CRISP3

2.52e-04175784af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|356C / Donor, Lineage, Cell class and subclass (all cells)

CFH FCGBP SOX21 CRISP3

2.52e-041757844bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DCAF6 MYO9A CELA2A

2.52e-041757841ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GALK1 PDLIM7 SPEG LGR6

2.52e-04175784067c7d89cfdf6ebf70692df64b9b79d752f093dd
ToppCellCOPD-Lymphoid-ILC_A|COPD / Disease state, Lineage and Cell class

IGF1R RNF125 GALNT11 GZMA

2.58e-04176784484452cb38fe4604f0910a068361ed461b5b0c21
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_Tem|Control / Disease, condition lineage and cell class

CFH FBLN5 GZMA NOSIP

2.63e-041777843fba0c5edf816ce7f3c2af424f46c83477528878
ToppCellChildren_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH SOX5 SPEG LGR6

2.63e-04177784b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH MYOF FBLN5 DLL1

2.63e-041777846f6cf93893daac6ae228df36219ee3acf8de8f97
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CFH HSPG2 FBLN5 SP5

2.63e-04177784599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCell10x5'v1-week_17-19-Lymphocytic_NK-T_NK-mature_NK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

HAVCR2 RNF125 GZMA LGR6

2.63e-041777840f2616a81f8fbede77c860b2126e3fa826672da3
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAVCR2 LRP12 SPEG TLR5

2.69e-04178784de6cd81e6d58e7687386df163471bf1901b9c0aa
Diseaselymphedema (is_implicated_in)

GJC2 FOXC2

6.55e-062762DOID:4977 (is_implicated_in)
Diseasecholesterol in small LDL measurement

TBKBP1 LPA PCIF1 ABCG8

7.88e-0649764EFO_0022227
DiseaseFc receptor-like protein 5 measurement

CFH PCIF1

1.96e-053762EFO_0802545
Diseaseinterleukin-11 receptor subunit alpha measurement

CFH IL11RA

1.96e-053762EFO_0020491
Diseaseserpin A9 measurement

CFH SERPINA9

3.92e-054762EFO_0802062
Diseasebeta-1,4-galactosyltransferase 6 measurement

CFH RNF125

6.51e-055762EFO_0801411
Diseasefree cholesterol to total lipids in large VLDL percentage

SLC12A4 LPA PCIF1

1.20e-0437763EFO_0022281
Diseasetotal cholesterol measurement, intermediate density lipoprotein measurement

TBKBP1 LPA PCIF1 ABCG8

1.27e-0499764EFO_0004574, EFO_0008595
Diseasetriglycerides to total lipids in large VLDL percentage

SLC12A4 LPA PCIF1

1.40e-0439763EFO_0022332
Diseasefree cholesterol measurement, intermediate density lipoprotein measurement

TBKBP1 LPA PCIF1 ABCG8

1.54e-04104764EFO_0008591, EFO_0008595
Diseaseapolipoprotein A 1 measurement, apolipoprotein B measurement

CFH TBKBP1 LPA ABCG8

1.72e-04107764EFO_0004614, EFO_0004615
Diseasehepatitis A virus cellular receptor 2 measurement

CFH HAVCR2

1.81e-048762EFO_0008151
Diseaseswitch-associated protein 70 measurement

FOXE1 CFH

1.81e-048762EFO_0802107
Diseasesuicide behaviour measurement

CTNND2 SLC23A2 STPG2

1.88e-0443763EFO_0006882
Diseasefree cholesterol to total lipids in very small VLDL percentage

LPA PCIF1 ABCG8

1.88e-0443763EFO_0022290
Diseaselow density lipoprotein cholesterol measurement, lipid measurement

TBKBP1 LPA PCIF1 ABCG8

2.19e-04114764EFO_0004529, EFO_0004611
Diseasetotal cholesterol measurement, low density lipoprotein cholesterol measurement

TBKBP1 LPA PCIF1 ABCG8

2.19e-04114764EFO_0004574, EFO_0004611
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

TBKBP1 LPA PCIF1 ABCG8

2.66e-04120764EFO_0004611, EFO_0004639
DiseaseCongenital myasthenic syndrome

MYO9A CHRNE

2.91e-0410762cv:C0751882
Diseasef-box/LRR-repeat protein 4 measurement

CFH PCIF1

2.91e-0410762EFO_0802538
Diseaseapolipoprotein B measurement

HAVCR2 MYOF GALK1 TBKBP1 LPA PCIF1 BBS1 ABCG8

3.06e-04663768EFO_0004615
Diseasetriglycerides to total lipids in large LDL percentage

LPA PCIF1 ABCG8

3.13e-0451763EFO_0022331
Diseasecholesteryl ester measurement, low density lipoprotein cholesterol measurement

TBKBP1 LPA PCIF1 ABCG8

3.21e-04126764EFO_0004611, EFO_0010351
Diseasephospholipids in IDL measurement

TBKBP1 PCIF1 ABCG8

3.31e-0452763EFO_0022164
Diseasetotal lipids in LDL measurement

TBKBP1 PCIF1 ABCG8

3.31e-0452763EFO_0022308
Diseasecholesterol to total lipids in large LDL percentage

LPA PCIF1 ABCG8

4.13e-0456763EFO_0022235
Diseasefree cholesterol to total lipids in medium VLDL percentage

LPA PCIF1 ABCG8

4.35e-0457763EFO_0022284
DiseaseRespiratory Depression

FBLN5 IGF1R

5.01e-0413762C0235063
DiseaseRespiratory Insufficiency

FBLN5 IGF1R

5.01e-0413762C0035229
DiseaseRespiratory Failure

FBLN5 IGF1R

5.01e-0413762C1145670
Diseasetriglycerides to total lipids in IDL percentage

LPA PCIF1 ABCG8

5.83e-0463763EFO_0022329
Diseaserostral middle frontal gyrus volume measurement

BCL2L10 ARRDC1

5.84e-0414762EFO_0010328
Diseasetriglycerides to total lipids in chylomicrons and extremely large VLDL percentage

LPA PCIF1

6.73e-0415762EFO_0022328
Diseasecholesterol to total lipids in very small VLDL percentage

LPA PCIF1 ABCG8

6.99e-0467763EFO_0022245
Diseasefatty acid measurement, linoleic acid measurement

LPA PCIF1 ABCG8

7.30e-0468763EFO_0005110, EFO_0006807
Diseasetriglycerides to total lipids in very small VLDL percentage

LPA PCIF1 ABCG8

7.61e-0469763EFO_0022341
Diseasesphingomyelin measurement

TBKBP1 LPA PCIF1 ABCG8 CHRNE

7.67e-04278765EFO_0010118
Diseasecolorectal mucinous adenocarcinoma

SOX5 RASGRF2

7.67e-0416762EFO_0009361
Diseasecholesteryl esters to total lipids in very small VLDL percentage

LPA PCIF1 ABCG8

8.27e-0471763EFO_0022259
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPA PCIF1

8.68e-0417762EFO_0022232
Diseasefree cholesterol to total lipids in small VLDL percentage

LPA PCIF1 ABCG8

9.70e-0475763EFO_0022287
DiseaseAge-related macular degeneration

CFH FBLN5

9.75e-0418762cv:C0242383
Diseaseuric acid measurement

SOX5 MYOF TMEM174 IGF1R PCNX3 MYO9A ZDHHC5

9.94e-04610767EFO_0004761
DiseaseLung diseases

FBLN5 IGF1R IRX2

1.09e-0378763C0024115
DiseaseCongenital hernia of foramen of Morgagni

IGF1R FOXC2

1.09e-0319762C0265699
DiseaseCongenital hernia of foramen of Bochdalek

IGF1R FOXC2

1.09e-0319762C0265700
Diseaseglaucoma (is_marker_for)

CFH FOXD3

1.21e-0320762DOID:1686 (is_marker_for)
DiseaseCongenital diaphragmatic hernia

IGF1R FOXC2

1.33e-0321762C0235833
Diseasefree cholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPA PCIF1

1.33e-0321762EFO_0022277
Diseasecholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage

LPA PCIF1

1.33e-0321762EFO_0022246
Diseaselipid measurement, lipoprotein measurement

TBKBP1 LPA ABCG8

1.64e-0390763EFO_0004529, EFO_0004732
Diseasestomach carcinoma (is_marker_for)

ERBB2 BCL2L10

1.74e-0324762DOID:5517 (is_marker_for)
Diseaselipid measurement, intermediate density lipoprotein measurement

TBKBP1 PCIF1 ABCG8

1.98e-0396763EFO_0004529, EFO_0008595
Diseasecholesterol to total lipids in small LDL percentage

PCIF1 ABCG8

2.20e-0327762EFO_0022241
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

TBKBP1 LPA PCIF1 ABCG8

2.33e-03215764EFO_0008317, EFO_0008591
Diseaseglucose metabolism disease (implicated_via_orthology)

IGF1R TLR5

2.37e-0328762DOID:4194 (implicated_via_orthology)
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

TBKBP1 LPA PCIF1 ABCG8

2.54e-03220764EFO_0004529, EFO_0008317

Protein segments in the cluster

PeptideGeneStartEntry
GYVAPLTCSPQPEYV

ERBB2

1126

P04626
GAYYAAPALDPALCV

ESX1

221

Q8N693
YLGYCAREPGTPEPA

BCL2L10

26

Q9HD36
LPPLGLDPATAAAYY

GSE1

236

Q14687
FPYPCYDPATREGDL

GZMA

101

P12544
VYIPDNYPDGDCPRL

AKTIP

126

Q9H8T0
AIGYPCPRYSNPADF

ABCG8

306

Q9H221
SCDNPYIPNGDYSPL

CFH

266

P08603
VAGALSCGDPTYPPY

CELA2A

11

P08217
SCGDPTYPPYVTRVV

CELA2A

16

P08217
SVAICPPIPYYLAVG

DCAF6

196

Q58WW2
PPIPYYLAVGCSDSS

DCAF6

201

Q58WW2
LPAPADLTVYSCPVY

DNHD1

4696

Q96M86
PDAPPAAAAAALYYS

CTNND2

241

Q9UQB3
PYEAPPSYEQSCGGV

ARRDC1

411

Q8N5I2
GAYFNRVPDLPYAPC

CHRNE

476

Q04844
DPCPVIDGPRYTFYT

NWD1

1331

Q149M9
GYYSVACQPPSEPRT

RC3H2

741

Q9HBD1
AAVFPCIASGYPTPD

HSPG2

3591

P98160
FSIDPQYPGASCYPE

EGR2

96

P11161
QPCHDPVVTPDGYLY

NOSIP

51

Q9Y314
PYVATAPELYGACAP

RB1CC1

1401

Q8TDY2
YPPARPVVSCQAADY

IL11RA

111

Q14626
PAARAPYGLADYAAP

FOXI3

31

A8MTJ6
PYGLADYAAPPAAAA

FOXI3

36

A8MTJ6
PSEYFYDGSCIPSPE

MYF5

11

P13349
IESYRACGSTIPPPY

LRP12

116

Q9Y561
ASVGEYGASPLCLPY

LGR6

706

Q9HBX8
PAAAAGLACPPDYSL

GJC2

321

Q5T442
PTAAPLPCDSYREGY

HES2

76

Q9Y543
GPLYTVCGTPTYVAP

DCLK2

546

Q8N568
YAGVCVPACPPNTYR

IGF1R

256

P08069
SSCDQPLGYPIYVSP

PCNX3

1771

Q9H6A9
YPPDLPAASVVICFY

GALNT11

146

Q8NCW6
YYPAAPLPGFSAVVV

GALK1

116

P51570
SCFVPVYCGLIPPTY

PNPLA1

151

Q8N8W4
LALPYAAAPPAAYGQ

FOXC2

301

Q99958
AIFCPPCYDVRYAPS

PDLIM7

326

Q9NR12
APGSLALYSCPAYGA

IRX2

11

Q9BZI1
YPELPDSCQPYGSCF

NBPF3

506

Q9H094
YPAPLESYDAQGALC

PRAMEF12

411

O95522
LVYCYPVRLAVSAPP

PCIF1

401

Q9H4Z3
LYVPYEQGAPCASCP

CRISP3

181

P54108
PGVDPFYTYPVAIRC

GPHB5

101

Q86YW7
HYQASVSPEPPCTYG

DLL1

66

O00548
PYLVLIPDVAAYCPA

FCGBP

331

Q9Y6R7
NPDAVAAPYCYTRDP

LPA

421

P08519
PDAVAAPYCYTRDPG

LPA

536

P08519
YYPPVEGPGCCSDLA

C1GALT1

291

Q9NS00
PGTYFCSCPPGYILL

FBLN5

266

Q9UBX5
TPALALASGPCVYVY

BBS1

101

Q8NFJ9
GAYCTFPASVLAPVP

DUSP5

351

Q16690
KPCVTPSAQAYGAPY

NKX2-3

236

Q8TAU0
AAAAALQYPYALPPV

FOXD3

296

Q9UJU5
VYLSDPCPGLYLAGP

IER5

46

Q5VY09
GKPQLDPYPAAYAAA

SOX21

261

Q9Y651
AALPASCAPAYVPYA

SP5

136

Q6BEB4
VYYPAASPGPCRVFG

FOXE1

211

O00358
PANPSAYAAAYAGPD

FOXE1

271

O00358
CNPPAVPYLGMYLTD

RASGRF2

1146

O14827
GQNAYLPCFYTPAAP

HAVCR2

31

Q8TDQ0
PPCSYELANPGYTNS

GCM2

271

O75603
LCYEPPTYSPAGNLE

SPIB

76

Q01892
TYIAPPAAIFYPSGA

SLC12A4

226

Q9UP95
APIYCVSPANAPSAY

SERPINA9

16

Q86WD7
PVDYYGIPFAAPTAL

UBAP2

836

Q5T6F2
TCPYCRAYLPSEGVP

RNF125

71

Q96EQ8
CYAHLYVTDVVPGPP

SPEG

1271

Q15772
GDYYACARLSCAPPP

SLC23A2

396

Q9UGH3
CFPPACDSTLGPAYY

STPG2

111

Q8N412
FLPESTACPYSYAAP

PROP1

146

O75360
QPAASCTPAAPPYYC

ZBTB47

126

Q9UFB7
ACACFSPPPYEEIYS

TMEM174

226

Q8WUU8
CPGLSLYVSPAVPIY

ZDHHC5

36

Q9C0B5
VYETTYSPPECPFCG

ZUP1

146

Q96AP4
YLTFLGAPCYAPALP

TNFRSF14

26

Q92956
YKAGCSDPYPVQLIP

SOX5

306

P35711
IAGPPADIYCVYPDS

TLR5

601

O60602
TIYYPPEGQPSCAVH

VSIG10L2

326

P0DP72
CAGFPIPESPAATAY

TBKBP1

546

A7MCY6
GLAPYPPAACLSTPY

GARIN5B

361

Q8N5Q1
YPGAISEGTIYCPIP

MYO9A

21

B2RTY4
VPTFGPCYLNLYGSP

MYOF

496

Q9NZM1